Lymphoma, Primary Cutaneous Anaplastic Large Cell
Lymphomatoid Papulosis
Lymphoma, Large-Cell, Anaplastic
Antigens, CD30
Lymphoma, T-Cell, Cutaneous
Lymphoma, Large B-Cell, Diffuse
Receptor Protein-Tyrosine Kinases
Lymphoma, T-Cell
Lymphoma, Non-Hodgkin
Lymphoma, B-Cell
Hodgkin Disease
Chromosomes, Human, Pair 2
Lymphoma, T-Cell, Peripheral
Protein-Tyrosine Kinases
FDG-PET in T-cell and NK-cell neoplasms. (1/11)
BACKGROUND: A growing number of studies demonstrate the utility of (18)fluoro-2-deoxyglucose positron emission tomography (FDG-PET) in the management of malignant lymphoma. The results of FDG-PET, however, have not been studied extensively for T-cell and natural killer (NK)-cell neoplasms. PATIENTS AND METHODS: We retrospectively evaluated pretreatment FDG-PET scans in 41 patients with T/NK-cell neoplasms diagnosed according to the World Health Organization (WHO) classification. Histological subtypes frequently included were peripheral T-cell lymphoma, unspecified (PTCLu, n = 11), extranodal NK/T-cell lymphoma, nasal type (ENKL, n = 8), primary cutaneous anaplastic large cell lymphoma (C-ALCL, n = 5), and angioimmunoblastic T-cell lymphoma (AILT, n = 4). RESULTS: FDG-PET detected a lymphoma lesion in at least one site in 36 out of 41 patients. The positive rate was equally high in most histological subtypes except for cutaneous lymphomas: PTCLu 91%, ENKL 100%, C-ALCL 60%, AILT 100%. All the patients without an FDG-avid lesion had lesions restricted to skin. Among patients who had cutaneous lesions, only 50% had FDG-avid cutaneous lesions, all of which were tumorous. The positive rate of FDG-PET for bone marrow involvement was only 20%. CONCLUSION: T/NK-cell neoplasms incorporated in this study were generally FDG-avid except for cutaneous lesions and bone marrow involvement. (+info)Recurrent translocations involving the IRF4 oncogene locus in peripheral T-cell lymphomas. (2/11)
(+info)Spectrum of CD30+ lymphoid proliferations in the eyelid lymphomatoid papulosis, cutaneous anaplastic large cell lymphoma, and anaplastic large cell lymphoma. (3/11)
(+info)Fatal outcome of deep-penetrating lower limb primary cutaneous anaplastic large cell lymphomas in two immunocompromised patients. (4/11)
(+info)Primary cutaneous CD30+ large-cell lymphoma presenting as a scrotal plaque. (5/11)
Primary cutaneous CD30+ large-cell lymphoma (CD30+ LCL) is a rare subtype of cutaneous T cell lymphoma. We report a patient with a one-year history of an enlarging scrotal plaque. Skin biopsy stained positive for CD30, and after thorough systemic evaluation, a diagnosis of primary cutaneous CD30+ LCL was made. Most commonly CD30+ LCL presents on the extremities and trunk. We present the first case to our knowledge of a patient initially presenting with a solitary scrotal nodule. When primary cutaneous CD30+ LCL is suspected, it is important to conduct a thorough systemic evaluation for systemic LCL and immunohistological studies for CD30- types. Ruling these conditions out will prevent unnecessarily aggressive treatment for primary cutaneous CD30+ LCL, an indolent disease with a favorable prognosis. (+info)Specificity of IRF4 translocations for primary cutaneous anaplastic large cell lymphoma: a multicenter study of 204 skin biopsies. (6/11)
(+info)Perils and pitfalls regarding differential diagnosis and treatment of primary cutaneous anaplastic large-cell lymphoma. (7/11)
(+info)EORTC, ISCL, and USCLC consensus recommendations for the treatment of primary cutaneous CD30-positive lymphoproliferative disorders: lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma. (8/11)
(+info)Primary cutaneous lymphomas are a group of non-Hodgkin lymphomas that primarily involve the skin. The primary cutaneous anaplastic large cell lymphoma (PCALCL) is a rare type of primary cutaneous lymphoma, accounting for less than 1% of all cutaneous lymphomas.
PCALCL is characterized by the presence of large, atypical cells called Reed-Sternberg cells or their variants, which are typically found in classical Hodgkin lymphoma. However, in PCALCL, these cells are primarily found in the skin without evidence of systemic involvement at the time of diagnosis.
PCALCL usually presents as one or more reddish-purple nodules or tumors on the skin that may ulcerate and can be tender or pruritic. The most common sites of involvement include the head, neck, trunk, and upper extremities.
The etiology of PCALCL is unknown, but it has been associated with immune suppression, including organ transplantation and human immunodeficiency virus (HIV) infection.
PCALCL is generally an indolent disease with a good prognosis, and most cases can be managed with local therapies such as surgical excision, radiation therapy, or intralesional injections of chemotherapy or corticosteroids. However, some cases may progress or recur, requiring systemic therapy with chemotherapy, immunotherapy, or targeted agents.
Overall, PCALCL is a rare and distinct type of primary cutaneous lymphoma that requires careful clinical evaluation and management by a multidisciplinary team of dermatologists, pathologists, and oncologists.
Lymphomatoid papulosis (LyP) is a rare, chronic skin disorder characterized by recurrent, self-healing papules and nodules. It is considered a low-grade T-cell lymphoma, but it is distinct from other cutaneous lymphomas due to its benign clinical course and lack of systemic involvement in most cases. The lesions typically undergo cycles of appearing, ulcerating, and then resolving over a period of several weeks to months, only to recur elsewhere on the body.
Histologically, LyP is characterized by an inflammatory infiltrate composed of small lymphocytes, histiocytes, eosinophils, and atypical large cells with Reed-Sternberg-like morphology. The condition is often associated with other lymphoproliferative disorders, such as mycosis fungoides or Hodgkin's lymphoma, and it is important to monitor patients closely for signs of progression to more aggressive lymphomas.
The exact cause of LyP remains unclear, but it is thought to involve an abnormal immune response and genetic factors. Treatment options include topical therapies, phototherapy, and systemic medications such as methotrexate or retinoids. However, the choice of treatment depends on the severity and extent of the disease, as well as the individual patient's needs and preferences.
Large cell anaplastic lymphoma is a type of cancer that starts in white blood cells called lymphocytes, which are part of the body's immune system. It is classified as a type of non-Hodgkin lymphoma (NHL).
Anaplastic large cell lymphoma (ALCL) is a subtype of NHL characterized by the presence of large cancer cells that look abnormal under a microscope. These cells are called "anaplastic" because they lack many of the usual features of mature lymphocytes.
ALCL can occur in many different parts of the body, including the lymph nodes, skin, lungs, and soft tissues. It is typically an aggressive form of NHL that grows and spreads quickly.
ALCL is further divided into two main subtypes based on the presence or absence of a genetic abnormality involving a protein called ALK (anaplastic lymphoma kinase). ALK-positive ALCL tends to occur in younger patients and has a better prognosis than ALK-negative ALCL.
Treatment for large cell anaplastic lymphoma typically involves chemotherapy, radiation therapy, and/or immunotherapy, depending on the stage and location of the cancer. In some cases, stem cell transplantation may also be recommended.
CD30 is a type of protein found on the surface of some cells in the human body, including certain immune cells like T-cells and B-cells. It is also known as Ki-1 antigen. CD30 plays a role in the regulation of the immune response and can be activated during an immune reaction.
CD30 is often used as a marker to identify certain types of cancer, such as Hodgkin lymphoma and anaplastic large cell lymphoma. These cancers are characterized by the presence of cells that express CD30 on their surface.
CD30 antigens can be targeted with immunotherapy, such as monoclonal antibodies, to treat these types of cancer. For example, brentuximab vedotin is a monoclonal antibody that targets CD30 and has been approved for the treatment of Hodgkin lymphoma and anaplastic large cell lymphoma.
Skin neoplasms refer to abnormal growths or tumors in the skin that can be benign (non-cancerous) or malignant (cancerous). They result from uncontrolled multiplication of skin cells, which can form various types of lesions. These growths may appear as lumps, bumps, sores, patches, or discolored areas on the skin.
Benign skin neoplasms include conditions such as moles, warts, and seborrheic keratoses, while malignant skin neoplasms are primarily classified into melanoma, squamous cell carcinoma, and basal cell carcinoma. These three types of cancerous skin growths are collectively known as non-melanoma skin cancers (NMSCs). Melanoma is the most aggressive and dangerous form of skin cancer, while NMSCs tend to be less invasive but more common.
It's essential to monitor any changes in existing skin lesions or the appearance of new growths and consult a healthcare professional for proper evaluation and treatment if needed.
Cutaneous T-cell lymphoma (CTCL) is a type of cancer that affects T-cells, a specific group of white blood cells called lymphocytes. These cells play a crucial role in the body's immune system and help protect against infection and disease. In CTCL, the T-cells become malignant and accumulate in the skin, leading to various skin symptoms and lesions.
CTCL is a subtype of non-Hodgkin lymphoma (NHL), which refers to a group of cancers that originate from lymphocytes. Within NHL, CTCL is categorized as a type of extranodal lymphoma since it primarily involves organs or tissues outside the lymphatic system, in this case, the skin.
The two most common subtypes of CTCL are mycosis fungoides and Sézary syndrome:
1. Mycosis fungoides (MF): This is the more prevalent form of CTCL, characterized by patches, plaques, or tumors on the skin. The lesions may be scaly, itchy, or change in size, shape, and color over time. MF usually progresses slowly, with early-stage disease often confined to the skin for several years before spreading to lymph nodes or other organs.
2. Sézary syndrome (SS): This is a more aggressive form of CTCL that involves not only the skin but also the blood and lymph nodes. SS is characterized by the presence of malignant T-cells, known as Sézary cells, in the peripheral blood. Patients with SS typically have generalized erythroderma (reddening and scaling of the entire body), pruritus (severe itching), lymphadenopathy (swollen lymph nodes), and alopecia (hair loss).
The diagnosis of CTCL usually involves a combination of clinical examination, skin biopsy, and immunophenotyping to identify the malignant T-cells. Treatment options depend on the stage and subtype of the disease and may include topical therapies, phototherapy, systemic medications, or targeted therapies.
Large B-cell lymphoma, diffuse is a type of cancer that starts in cells called B-lymphocytes, which are part of the body's immune system. "Large B-cell" refers to the size and appearance of the abnormal cells when viewed under a microscope. "Diffuse" means that the abnormal cells are spread throughout the lymph node or tissue where the cancer has started, rather than being clustered in one area.
This type of lymphoma is typically aggressive, which means it grows and spreads quickly. It can occur almost anywhere in the body, but most commonly affects the lymph nodes, spleen, and bone marrow. Symptoms may include swollen lymph nodes, fever, night sweats, weight loss, and fatigue.
Treatment for large B-cell lymphoma, diffuse typically involves chemotherapy, radiation therapy, or a combination of both. In some cases, stem cell transplantation or targeted therapy may also be recommended. The prognosis varies depending on several factors, including the stage and location of the cancer, as well as the patient's age and overall health.
Lymphoma is a type of cancer that originates from the white blood cells called lymphocytes, which are part of the immune system. These cells are found in various parts of the body such as the lymph nodes, spleen, bone marrow, and other organs. Lymphoma can be classified into two main types: Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL).
HL is characterized by the presence of a specific type of abnormal lymphocyte called Reed-Sternberg cells, while NHL includes a diverse group of lymphomas that lack these cells. The symptoms of lymphoma may include swollen lymph nodes, fever, night sweats, weight loss, and fatigue.
The exact cause of lymphoma is not known, but it is believed to result from genetic mutations in the lymphocytes that lead to uncontrolled cell growth and division. Exposure to certain viruses, chemicals, and radiation may increase the risk of developing lymphoma. Treatment options for lymphoma depend on various factors such as the type and stage of the disease, age, and overall health of the patient. Common treatments include chemotherapy, radiation therapy, immunotherapy, and stem cell transplantation.
Receptor Protein-Tyrosine Kinases (RTKs) are a type of transmembrane receptors found on the cell surface that play a crucial role in signal transduction and regulation of various cellular processes, including cell growth, differentiation, metabolism, and survival. They are called "tyrosine kinases" because they possess an intrinsic enzymatic activity that catalyzes the transfer of a phosphate group from ATP to tyrosine residues on target proteins, thereby modulating their function.
RTKs are composed of three main domains: an extracellular domain that binds to specific ligands (growth factors, hormones, or cytokines), a transmembrane domain that spans the cell membrane, and an intracellular domain with tyrosine kinase activity. Upon ligand binding, RTKs undergo conformational changes that lead to their dimerization or oligomerization, which in turn activates their tyrosine kinase activity. Activated RTKs then phosphorylate specific tyrosine residues on downstream signaling proteins, initiating a cascade of intracellular signaling events that ultimately result in the appropriate cellular response.
Dysregulation of RTK signaling has been implicated in various human diseases, including cancer, diabetes, and developmental disorders. As such, RTKs are important targets for therapeutic intervention in these conditions.
T-cell lymphoma is a type of cancer that affects the T-cells, which are a specific type of white blood cell responsible for immune function. These lymphomas develop from mature T-cells and can be classified into various subtypes based on their clinical and pathological features.
T-cell lymphomas can arise in many different organs, including the lymph nodes, skin, and other soft tissues. They often present with symptoms such as enlarged lymph nodes, fever, night sweats, and weight loss. The diagnosis of T-cell lymphoma typically involves a biopsy of the affected tissue, followed by immunophenotyping and genetic analysis to determine the specific subtype.
Treatment for T-cell lymphomas may include chemotherapy, radiation therapy, immunotherapy, or stem cell transplantation, depending on the stage and aggressiveness of the disease. The prognosis for T-cell lymphoma varies widely depending on the subtype and individual patient factors.
Non-Hodgkin lymphoma (NHL) is a type of cancer that originates in the lymphatic system, which is part of the immune system. It involves the abnormal growth and proliferation of malignant lymphocytes (a type of white blood cell), leading to the formation of tumors in lymph nodes, spleen, bone marrow, or other organs. NHL can be further classified into various subtypes based on the specific type of lymphocyte involved and its characteristics.
The symptoms of Non-Hodgkin lymphoma may include:
* Painless swelling of lymph nodes in the neck, armpits, or groin
* Persistent fatigue
* Unexplained weight loss
* Fever
* Night sweats
* Itchy skin
The exact cause of Non-Hodgkin lymphoma is not well understood, but it has been associated with certain risk factors such as age (most common in people over 60), exposure to certain chemicals, immune system deficiencies, and infection with viruses like Epstein-Barr virus or HIV.
Treatment for Non-Hodgkin lymphoma depends on the stage and subtype of the disease, as well as the patient's overall health. Treatment options may include chemotherapy, radiation therapy, immunotherapy, targeted therapy, stem cell transplantation, or a combination of these approaches. Regular follow-up care is essential to monitor the progression of the disease and manage any potential long-term side effects of treatment.
B-cell lymphoma is a type of cancer that originates from the B-lymphocytes, which are a part of the immune system and play a crucial role in fighting infections. These cells can develop mutations in their DNA, leading to uncontrolled growth and division, resulting in the formation of a tumor.
B-cell lymphomas can be classified into two main categories: Hodgkin's lymphoma and non-Hodgkin's lymphoma. B-cell lymphomas are further divided into subtypes based on their specific characteristics, such as the appearance of the cells under a microscope, the genetic changes present in the cancer cells, and the aggressiveness of the disease.
Some common types of B-cell lymphomas include diffuse large B-cell lymphoma, follicular lymphoma, mantle cell lymphoma, and Burkitt lymphoma. Treatment options for B-cell lymphomas depend on the specific subtype, stage of the disease, and other individual factors. Treatment may include chemotherapy, radiation therapy, immunotherapy, targeted therapy, or stem cell transplantation.
Hodgkin disease, also known as Hodgkin lymphoma, is a type of cancer that originates in the white blood cells called lymphocytes. It typically affects the lymphatic system, which is a network of vessels and glands spread throughout the body. The disease is characterized by the presence of a specific type of abnormal cell, known as a Reed-Sternberg cell, within the affected lymph nodes.
The symptoms of Hodgkin disease may include painless swelling of the lymph nodes in the neck, armpits, or groin; fever; night sweats; weight loss; and fatigue. The exact cause of Hodgkin disease is unknown, but it is thought to involve a combination of genetic, environmental, and infectious factors.
Hodgkin disease is typically treated with a combination of chemotherapy, radiation therapy, and/or immunotherapy, depending on the stage and extent of the disease. With appropriate treatment, the prognosis for Hodgkin disease is generally very good, with a high cure rate. However, long-term side effects of treatment may include an increased risk of secondary cancers and other health problems.
Human chromosome pair 2 consists of two rod-shaped structures present in the nucleus of each cell of the human body. Each member of the pair contains thousands of genes and other genetic material, encoded in the form of DNA molecules. Chromosomes are the physical carriers of inheritance, and human cells typically contain 23 pairs of chromosomes for a total of 46 chromosomes.
Chromosome pair 2 is one of the autosomal pairs, meaning that it is not a sex chromosome (X or Y). Each member of chromosome pair 2 is approximately 247 million base pairs in length and contains an estimated 1,000-1,300 genes. These genes play crucial roles in various biological processes, including development, metabolism, and response to environmental stimuli.
Abnormalities in chromosome pair 2 can lead to genetic disorders, such as cat-eye syndrome (CES), which is characterized by iris abnormalities, anal atresia, hearing loss, and intellectual disability. This disorder arises from the presence of an extra copy of a small region on chromosome 2, resulting in partial trisomy of this region. Other genetic conditions associated with chromosome pair 2 include proximal 2q13.3 microdeletion syndrome and Potocki-Lupski syndrome (PTLS).
T-cell peripheral lymphoma is a type of cancer that affects the T-cells, which are a type of white blood cell that plays a crucial role in the body's immune system. This type of lymphoma is called "peripheral" because it typically develops in T-cells that have matured and are found in various tissues and organs outside of the bone marrow, such as the lymph nodes, spleen, skin, and digestive tract.
Peripheral T-cell lymphomas (PTCL) are relatively rare and can be aggressive, with a tendency to spread quickly throughout the body. They can arise from different types of T-cells, leading to various subtypes of PTCL that may have different clinical features, treatment options, and prognoses.
Some common subtypes of peripheral T-cell lymphoma include:
1. PTCL, not otherwise specified (NOS): This is the most common subtype, accounting for about 25-30% of all PTCL cases. It includes cases that do not fit into any specific category or have features of more than one subtype.
2. Anaplastic large cell lymphoma (ALCL): ALCL can be further divided into two groups: systemic ALCL and cutaneous ALCL. Systemic ALCL is a more aggressive form, while cutaneous ALCL tends to be less aggressive and primarily affects the skin.
3. Angioimmunoblastic T-cell lymphoma (AITL): AITL is an aggressive subtype that often involves the lymph nodes and can affect other organs such as the spleen, liver, and bone marrow. It frequently presents with B symptoms (fever, night sweats, and weight loss) and abnormal blood tests.
4. Enteropathy-associated T-cell lymphoma (EATL): EATL is a rare but aggressive subtype that primarily affects the intestines, particularly in individuals with a history of celiac disease or gluten sensitivity.
5. Adult T-cell leukemia/lymphoma (ATLL): ATLL is caused by the human T-cell leukemia virus type 1 (HTLV-1) and primarily affects adults from regions where HTLV-1 is endemic, such as Japan, the Caribbean, and parts of Africa.
Treatment for PTCL depends on the specific subtype, stage, and individual patient factors. Common treatment options include chemotherapy, targeted therapy, immunotherapy, radiation therapy, stem cell transplantation, or a combination of these approaches. Clinical trials are also available for eligible patients to test new therapies and combinations.
Protein-Tyrosine Kinases (PTKs) are a type of enzyme that plays a crucial role in various cellular functions, including signal transduction, cell growth, differentiation, and metabolism. They catalyze the transfer of a phosphate group from ATP to the tyrosine residues of proteins, thereby modifying their activity, localization, or interaction with other molecules.
PTKs can be divided into two main categories: receptor tyrosine kinases (RTKs) and non-receptor tyrosine kinases (NRTKs). RTKs are transmembrane proteins that become activated upon binding to specific ligands, such as growth factors or hormones. NRTKs, on the other hand, are intracellular enzymes that can be activated by various signals, including receptor-mediated signaling and intracellular messengers.
Dysregulation of PTK activity has been implicated in several diseases, such as cancer, diabetes, and inflammatory disorders. Therefore, PTKs are important targets for drug development and therapy.
Human chromosome pair 5 consists of two rod-shaped structures present in the nucleus of human cells, which contain genetic material in the form of DNA and proteins. Each member of chromosome pair 5 is a single chromosome, and humans typically have 23 pairs of chromosomes for a total of 46 chromosomes in every cell of their body (except gametes or sex cells, which contain 23 chromosomes).
Chromosome pair 5 is one of the autosomal pairs, meaning it is not a sex chromosome. Each member of chromosome pair 5 is approximately 197 million base pairs in length and contains around 800-900 genes that provide instructions for making proteins and regulating various cellular processes.
Chromosome pair 5 is associated with several genetic disorders, including cri du chat syndrome (resulting from a deletion on the short arm of chromosome 5), Prader-Willi syndrome and Angelman syndrome (both resulting from abnormalities in gene expression on the long arm of chromosome 5).
Monomorphic epitheliotropic intestinal T cell lymphoma
HOXC4
Cutaneous T-cell lymphoma
Anaplastic large-cell lymphoma
CD30
T-cell lymphoma
Günter Burg
CD30+ cutaneous T-cell lymphoma
Anaplastic lymphoma kinase
Brentuximab vedotin
Lymphoma
Tumors of the hematopoietic and lymphoid tissues
Breast implant
List of cancer types
International Classification of Diseases for Oncology
List of skin conditions
T cell
Index of oncology articles
Plasmablastic lymphoma
Chemotherapy
Diffuse large B-cell lymphoma
Breast augmentation
Rhabdomyosarcoma
Diffuse large B-cell lymphoma associated with chronic inflammation
Epstein-Barr virus-associated lymphoproliferative diseases
Anaplastic Large Cell Lymphoma: Overview, Subtypes of ALCL, Genetic-Molecular Characteristics and Their Effects
Anaplastic Large Cell Lymphoma: Overview, Subtypes of ALCL, Genetic-Molecular Characteristics and Their Effects
Anaplastic Large Cell Lymphoma: Overview, Subtypes of ALCL, Genetic-Molecular Characteristics and Their Effects
Lymphoma, Primary Cutaneous Anaplastic Large Cell | Profiles RNS
Treatment for Specific Types of Skin Lymphoma | American Cancer Society
MEDLINE Data Changes - 2008. NLM Technical Bulletin. 2007 Nov-Dec
Relapses of primary cutaneous anaplastic large-cell lymphoma in a female immunocompetent patient with persistent chlamydophila...
Primary Cutaneous Anaplastic Large-Cell Lymphoma With Aberrant CD20 Expression: Case Report and Review of the Literature. Mark...
These highlights do not include all the information needed to use ADCETRIS safely and effectively. See full prescribing...
Pseudocarcinomatous Hyperplasia Masquerading as a Well-Differentiated Squamous Cell Carcinoma Associated With Primary...
chemotherapy | West Indian Medical Journal
Cutaneous T-Cell Lymphoma Clinical Presentation: History, Physical Examination
Monomorphic epitheliotropic intestinal T cell lymphoma - Wikipedia
Brentuximab Vedotin Injection: MedlinePlus Drug Information
Edward Perry Jr, MD | Yale School of Medicine
Biomarkers Search
Search Results: Occipital neck, Rash or multiple lesions
Cutaneous T-Cell Lymphoma: Practice Essentials, Background, Pathophysiology
Sebastian Fernandez-Pol's Profile | Stanford Profiles
Primary cutaneous T-cell lymphomas other than mycosis fungoides and Sézary syndrome. Part I: Clinical and histologic features...
ICD-10 Code for Anaplastic large cell lymphoma, ALK-positive, lymph nodes of inguinal region and lower limb- C84.65- Codify by...
Progressive multifocal leukoencephalopathy associated with brentuximab vedotin therapy: a report of 5 cases from the Southern...
Anaplastic large cell lymphoma - ကလေးများတွင် Lymphoma Australia
皮肤癌概述 - 相关疾病总结 | BMJ Best Practice
FDA warns about clarithromycin in heart disease | ACP Internist
Brentuximab vedotin for untreated CD30-positive peripheral T-cell lymphoma - Health & Fitness
Anaplastic Large Cell Lymphoma (ALCL) - Lymphoma Australia
Anaplastic Large Cell Lymphoma (ALCL) - Lymphoma Australia
Anaplastic large cell lymphoma overview - wikidoc
Anaplastic dako nga cell lymphoma - sa mga bata - Lymphoma Australia
Panniculitis-like T-cell lym1
- These diseases include mycosis fungoides and subcutaneous panniculitis-like T-cell lymphoma. (dana-farber.org)
Diffuse8
- Purpose Diffuse large B-cell lymphoma (DLBCL) is the most common hematologic malignancy worldwide. (koreamed.org)
- T-cell/histiocyte-rich large B-cell lymphoma - a distinct clinicopathologic entity or a variant of diffuse large B cell lymphoma? (llu.edu)
- Diffuse large cell lymphomas and their mimics. (llu.edu)
- A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. (lookformedical.com)
- DNA-microarray analysis of Burkitt's lymphoma and diffuse large B-cell lymphoma (DLBCL) showing differences in gene expression patterns. (newworldencyclopedia.org)
- The most common non-Hodgkin lymphoma diagnoses in children are Burkitt lymphoma, diffuse large B-cell lymphoma, lymphoblastic lymphoma, and anaplastic large cell lymphoma. (dana-farber.org)
- Primary central nervous system lymphoma in children is usually of the diffuse large B-cell lymphoma type. (dana-farber.org)
- diffuse non-Hodgkin lymphoma (C83. (who.int)
Mycosis8
- Mycosis fungoides is the most common type, accounting for 60% of CTCLs and almost half of all primary cutaneous lymphomas. (medscape.com)
- Primary cutaneous CD30+ T-cell lymphoproliferative disorders (CD30+ LPD) are the second most common cutaneous lymphomas after mycosis fungoides (MF) and Sézary syndrome (SS), representing approximately 30% of all cutaneous lymphomas. (aad.org)
- [6] This approval is for patients with primary cutaneous anaplastic large cell lymphoma (pcALCL) and CD30-expressing mycosis fungoides (MF). (mdwiki.org)
- November 9, 2017 - Seattle Genetics announced the FDA approval of Adcetris (brentuximab vedotin) for the treatment of adult patients with primary cutaneous anaplastic large cell lymphoma (pcALCL) or CD30-expressing mycosis fungoides (MF) who have received prior systemic therapy. (optumrx.com)
- 1 CD30+ LPD is the second most common group of cutaneous T-cell lymphomas (CTCL) after mycosis fungoides (MF) and is regarded as an indolent lymphoproliferative disorder 1 LyP typically manifests clinically as a recurrent eruption of papules and nodules with variable central ulceration, scale or crust that resolve spontaneously within several weeks and may result in hyperpigmentation, hypopigmentation, and scarring. (nextstepsinderm.com)
- Cutaneous T-cell lymphoma is a general term from mycosis fungoides or occur spontane- to identify non-Hodgkin's T-cell lymphomas ously, although some authors now consider that primarily affect the skin. (bvsalud.org)
- subtypes of cutaneous T-cell lymphoma, SS is a malignant neoplasm originating the most common of which are mycosis from T lymphocytes, which involves the fungoides and Sézary syndrome (SS). (bvsalud.org)
- SS and mycosis fungoides are closely derma, superficial adenopathy, and atyp- related entities, with mycosis fungoides ical cells in the blood1. (bvsalud.org)
CTCL7
- About 20% of all patients in the Care Center have cutaneous T-cell lymphoma, or CTCL, which is a type of Non-Hodgkin lymphoma . (mdanderson.org)
- CTCL affects lymphocytes, which are cells that help the body fight off infection. (mdanderson.org)
- Cutaneous T-cell lymphoma (CTCL) (see the image below) is a heterogeneous group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin, with no evidence of extracutaneous disease at the time of diagnosis. (medscape.com)
- Collectively, CTCL is classified as a type of non-Hodgkin lymphoma (NHL). (medscape.com)
- Among the changes to CTCL classification were the addition of primary cutaneous acral CD8 + T-cell lymphoma as a new provisional entity. (medscape.com)
- In November 2017, the FDA approved brentuximab vedotin as a treatment for patients with cutaneous T-cell lymphoma (CTCL) who have received prior systemic therapy. (mdwiki.org)
- Cutaneous T cell lymphoma (CTCL) is a chronic disease that negatively impacts quality of life (QoL) and, in advanced stages, has poor prognosis. (ashpublications.org)
Tumors11
- My research interests comprise cutaneous tumors with emphasis in lymphomas and melanoma. (mdanderson.org)
- In lymphomas I have conducted studies in rare aggressive primary cutaneous tumors such as gamma/delta T cell lymphoma (expanding the description of the epidermotropic variant) as well as more indolent entities such as lymphomatoid papulosis (type D) and CD4-positive small to medium size T cell lymphoproliferative disorders. (mdanderson.org)
- Results: The association of retinoid signaling and clinical parameters could be validated in a large independent tumor set, but its relevance in primary nephrectomy tumors from very young children may be different. (uni-wuerzburg.de)
- Cutaneous T-cell lymphomas (CTCLs) are a group of disorders characterized by abnormal accumulation of malignant T-cells in the skin, which may result in the development of rashes, plaques, and tumors. (patientworthy.com)
- A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
- Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
- The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease. (lookformedical.com)
- B-cell lymphoid tumors that occur in association with AIDS. (lookformedical.com)
- They play a major role in defending the host from both tumors and virally infected cells. (newworldencyclopedia.org)
- These can occur in lymph nodes or in sites such as the gastrointestinal tract or the inner eyelids, where these tumors are referred to as mucosa-associated lymphoid tissue (MALT) lymphomas. (dana-farber.org)
- Overview of Lymphoma Lymphomas are a heterogeneous group of tumors arising in the reticuloendothelial and lymphatic systems. (msdmanuals.com)
Malignant18
- PC-ALCL is one of the primary cutaneous CD30 + T-cell lymphoproliferative disorders, a wide spectrum of disease, with lymphomatoid papulosis (LyP) at the benign end of the spectrum and PC-ALCL at the malignant end. (medscape.com)
- Monomorphic epitheliotropic intestinal T cell lymphoma (MEITL) (formerly termed enteropathy-associated T cell lymphoma, type II) is an extremely rare peripheral T-cell lymphoma that involves the malignant proliferation of a type of lymphocyte, the T cell, in the gastrointestinal tract (i.e. (wikipedia.org)
- The malignant T cells in MEITL can be identified by: their expression of cluster of differentiation (i.e. (wikipedia.org)
- However, in up to 25% of cases the malignant cells in MEITL also express markers of B cell lymphocytes. (wikipedia.org)
- however, it does not clearly establish the original type of lymphocytes which became MEITL's malignant cells. (wikipedia.org)
- These cells are not infected with the Epstein-Barr virus and therefore have not become malignant as a consequence of this virus's malignancy-producing effects on lymphocytes as it does in other types of GI tract lymphomas. (wikipedia.org)
- Rather, the malignant T cells in MEITL bear various genetic abnormalities that may promote their malignancy. (wikipedia.org)
- Also, the term "primary cutaneous CD4 + small/medium T-cell lymphoma" was changed to "primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder" because of its indolent clinical behavior and uncertain malignant potential. (medscape.com)
- A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. (lookformedical.com)
- Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
- Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation. (lookformedical.com)
- Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. (lookformedical.com)
- A group of lymphomas exhibiting clonal expansion of malignant T-lymphocytes arrested at varying stages of differentiation as well as malignant infiltration of the skin. (lookformedical.com)
- A group of malignant lymphomas thought to derive from peripheral T-lymphocytes in lymph nodes and other nonlymphoid sites. (lookformedical.com)
- The antibody portion of the drug attaches to CD30 on the surface of malignant cells, delivering MMAE which is responsible for the anti-tumour activity. (mdwiki.org)
- Non-Hodgkin lymphomas are a heterogeneous group of disorders involving malignant monoclonal proliferation of lymphoid cells in lymphoreticular sites, including lymph nodes, bone marrow, the spleen, the liver, and the gastrointestinal tract. (msdmanuals.com)
- Hodgkin Lymphoma Hodgkin lymphoma is a localized or disseminated malignant proliferation of cells of the lymphoreticular system, primarily involving lymph node tissue, spleen, liver, and bone marrow. (msdmanuals.com)
- A dermatology work-up was initiated, and the síndrome de Sézary initial diagnosis of malignant T-cell neoplasm was confirmed. (bvsalud.org)
Subcutaneous2
- Lupus panniculitis can simulate subcutaneous T-cell lymphoma. (dermnetnz.org)
- A new technique has been presented that results in an acceleration of delayed primary healing with full thickness skin and subcutaneous tissue coverage. (who.int)
Peripheral3
- Purpose We conducted a nationwide, multicenter, prospective registry study for newly diagnosed patients with peripheral T-cell lymphoma (PTCL) to better define the clinical characteristics, treatment patterns, survival outcomes, and the. (koreamed.org)
- In November 2018, the FDA expanded the approved use of brentuximab vedotin in combination with chemotherapy for adults with certain types of peripheral T-cell lymphoma (PTCL). (mdwiki.org)
- Most lymphomas are nodal with variable involvement of the bone marrow and peripheral blood. (msdmanuals.com)
Lymphomatoid papulosis6
- According to the World Health Organization (WHO), CD30+ LPD include primary cutaneous anaplastic large cell lymphoma (pcALCL), lymphomatoid papulosis (LyP), and borderline lesions. (aad.org)
- Lymphomatoid papulosis (LyP) is a recurrent, chronic, self-healing eruption that exists on a continuum with primary cutaneous anaplastic large cell lymphoma (C-ALCL). (logicalimages.com)
- EORTC, ISCL, and USCLC consensus recommendations for the treatment of primary cutaneous CD30-positive lymphoproliferative disorders: lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma. (qxmd.com)
- Primary cutaneous CD30(+) lymphoproliferative disorders (CD30(+) LPDs) are the second most common form of cutaneous T-cell lymphomas and include lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma. (qxmd.com)
- Lymphomatoid papulosis (LyP) is a CD30+ T-cell lymphoproliferative disorder (LPD) presenting as a recurrent eruption of papules and nodules which resolve spontaneously. (nextstepsinderm.com)
- Lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large cell lymphoma (ALCL) comprise a disease spectrum known as primary cutaneous CD30+ T-cell lymphoproliferative disorders (CD30+ LPD). (nextstepsinderm.com)
Systemic9
- The primary cutaneous form of ALCL (PC-ALCL), seen in the image below, is defined by skin-only involvement without systemic dissemination at presentation. (medscape.com)
- The initial diagnostic evaluation of patients with any lymphoproliferative malignancy should include a careful history and physical examination, with close attention paid to the presence of systemic B symptoms, lymph node involvement, organomegaly, and evidence of cutaneous involvement. (medscape.com)
- Anaplastic lymphoma kinase (ALK) protein may be detected in most cases (60-70%) of systemic ALCL by immunohistochemistry. (medscape.com)
- Background CD30+ T-cell lymphoproliferations comprise a spectrum of clinically heterogeneous entities, including systemic anaplastic large cell lymphomas (ALK- and ALK+) and primary cutaneous CD30+ T-cell lymphoproliferative disorders. (uni-wuerzburg.de)
- Design and Methods We evaluated biopsies from 19 patients with primary cutaneous CD30+ lymphoproliferative disorders, 38 with ALK- and 33 with ALK+ systemic anaplastic large cell lymphoma. (uni-wuerzburg.de)
- In addition, primary cutaneous CD30+ lymphoproliferative disorders showed such a similar expression pattern to that of systemic anaplastic large cell lymphomas, that none of the markers we investigated can reliably distinguish between these CD30+ T-cell lymphoproliferations. (uni-wuerzburg.de)
- While this application was accepted, the committee noted that on the basis of inadequate cost-benefit, the medicine would not be made available more generally for the first-line treatment of relapsed or refractory systemic anaplastic large cell lymphoma (sALCL). (mdwiki.org)
- Additionally, systemic or localized anaplastic large cell lymphomas that only affect the skin are treated with brentuximab vedotin (primary cutaneous). (arkonsolution.com)
- Additionally, patients with systemic anaplastic large cell lymphoma did not respond to at least one prior multiple drug therapy. (arkonsolution.com)
Neoplasms2
- Within the B-cell and T-cell categories, two subdivisions are recognized: precursor neoplasms, which correspond to the earliest stages of differentiation, and more mature differentiated neoplasms. (medscape.com)
- Lymphomas are part of the broad group of diseases called hematological neoplasms. (newworldencyclopedia.org)
Pseudolymphoma3
- Related articles include Cutaneous B-Cell Lymphoma and Cutaneous Pseudolymphoma . (medscape.com)
- What is cutaneous pseudolymphoma? (dermnetnz.org)
- Cutaneous pseudolymphoma refers to a group of conditions that simulate a lymphoma (blood cell cancer ), but behave in a harmless manner. (dermnetnz.org)
Small lymphocy1
- Background/Aims: Little attention is paid to chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) in Korea due to the rarity of the disease. (koreamed.org)
Clinical10
- Striking clinical features include frequent cutaneous and extranodal involvement, young age at presentation, and male predominance. (medscape.com)
- However, subsequent studies found significant clinical, pathologic, and pathophysiological differences between these two types of lymphoma. (wikipedia.org)
- The abstracts, including five oral presentations, highlight updated and interim efficacy and safety clinical trial results for ADCETRIS in both early- and advanced stage settings of classical Hodgkin lymphoma (cHL), and in patients with other CD30-expressing lymphomas and other rare cancers. (businesswire.com)
- Computed tomography-based tumor volume in non-Hodgkin lymphoma: clinical correlation and comparison with magnetic resonance imaging. (medscape.com)
- The aim of this study was to describe the epidemiology of chronic wounds in a large cohort of patients from a tertiary hospital out-patient clinic, and examine the significance of serum mannan-binding lectin for the occurrence and clinical presentation of such wounds. (medicaljournals.se)
- Trusted and used in more than 2,300 hospitals, large clinics, and medical schools to improve clinical decision-making. (logicalimages.com)
- The diagnosis of cutaneous T-cell lymphomas is based upon a thorough clinical evaluation, detection of certain symptoms and physical findings, a detailed patient history, and a variety of specialized tests. (patientworthy.com)
- The Working Formulation, originally proposed in 1982, classified and grouped lymphomas by morphology and clinical behavior (ie, low, intermediate, or high grade) with 10 subgroups labeled A to J.{Ref 1} In 1994, the Revised European-American Lymphoma (REAL) classification attempted to apply immunophenotypic and genetic features in identifying distinct clinicopathologic NHL entities. (medscape.com)
- It was advanced to clinical evaluations is patients with B-cell malignancies, and to determine efficacy against difficult-to-treat autoimmune or inflammatory conditions. (guidetoimmunopharmacology.org)
- Initial management consisted of en una paciente con topical corticosteroids and oral antihistamines with little clinical response. (bvsalud.org)
Hodgkin Lymphoma29
- Brentuximab vedotin injection is used alone or in combination with other chemotherapy medications to treat adult patients with certain types of Hodgkin lymphoma. (medlineplus.gov)
- Brentuximab vedotin is used in combination with other chemotherapy in pediatric patients 2 years or older as first treatment for Hodgkin lymphoma. (medlineplus.gov)
- The investigation of ADCETRIS as a single agent or in novel combinations with other agents demonstrates its continued potential to help people impacted by early- and advanced stage Hodgkin lymphoma," said Marjorie Green, M.D., Senior Vice President and Head of Late-Stage Development at Seagen. (businesswire.com)
- Which medications in the drug class Antineoplastic Agents, mTOR Kinase Inhibitors are used in the treatment of Non-Hodgkin Lymphoma (NHL)? (medscape.com)
- Hodgkin lymphoma with cutaneous involvement. (medscape.com)
- Adult Non-Hodgkin Lymphoma Treatment (PDQ®): Health Professional Version. (medscape.com)
- Follicular non-Hodgkin lymphoma grades 3A and 3B have a similar outcome and appear incurable with anthracycline-based therapy. (medscape.com)
- Cancer Stat Facts: Non-Hodgkin Lymphoma. (medscape.com)
- Time trends in risk and risk determinants of non-hodgkin lymphoma in solid organ transplant recipients. (medscape.com)
- CD30 positivity may also be observed in large cell transformation in MF, Hodgkin lymphoma, and other reactive disorders. (aad.org)
- Non-Hodgkin lymphoma (NHL) represents a heterogeneous group of malignancies of different biology and prognosis. (medscape.com)
- Brentuximab vedotin , sold under the brand name Adcetris , is a medication used to treat Hodgkin lymphoma (HL) and certain non-Hodgkin lymphoma (NHL). (mdwiki.org)
- a type of non-Hodgkin lymphoma) in patients who have not previously received treatment. (arkonsolution.com)
- Anaplastic large-cell lymphoma and Hodgkin lymphoma cells contain a protein called CD30, the target of the drug brentuximab. (arkonsolution.com)
- Patients with Hodgkin lymphoma benefit greatly from second-line treatment with benuximab vedotin and ESHAP. (arkonsolution.com)
- People with stage 3 or stage 4 Hodgkin lymphoma who have not previously received treatment and those who did not respond well to a stem cell transplant. (arkonsolution.com)
- Some children and teenagers with Hodgkin lymphoma might not require radiation therapy at all, or it could reduce the need for it. (arkonsolution.com)
- In recent research, children and teenagers with a high-risk type of Hodgkin lymphoma were treated with the targeted drug brentuximab vedotin (Adcetris) instead of one chemotherapeutic drug. (arkonsolution.com)
- The purpose of this study is to test the benefit of a chemotherapy drug called romidepsin in patients with T Cell Non-Hodgkin Lymphoma (T NHL) who have undergone autologous transplantation. (clinicaltrialsgps.com)
- Lymphoma commonly is categorized broadly as Hodgkin's lymphoma (HL) and non-Hodgkin lymphoma (NHL, all other types of lymphoma). (newworldencyclopedia.org)
- Hodgkin lymphoma, as well as other minor groups. (newworldencyclopedia.org)
- Children and teens with rare childhood non-Hodgkin lymphoma are treated at Dana-Farber/Boston Children's Cancer and Blood Disorders Center through the Childhood Lymphoma Program in our Childhood Hematologic Malignancy Center . (dana-farber.org)
- Learn more about childhood non-Hodgkin lymphoma , including diagnosis and treatment . (dana-farber.org)
- non-Hodgkin lymphoma, other and unspecified types (C85. (who.int)
- The major types are Hodgkin lymphoma Non-Hodgkin lymphoma See table Comparison of Hodgkin. (msdmanuals.com)
- Non-Hodgkin lymphoma is not one disease but rather a category of lymphocyte cancers with a number of subgroups largely divided into aggressive and indolent types. (msdmanuals.com)
- Non-Hodgkin lymphoma is the 2nd most common cancer in HIV-infected patients Non-Hodgkin lymphoma AIDS-defining cancers in patients infected with HIV are Kaposi sarcoma Lymphoma, Burkitt (or equivalent term) Lymphoma, immunoblastic (or equivalent term) Lymphoma, primary, of central nervous system read more , and some AIDS patients present with lymphoma. (msdmanuals.com)
- Indeed, patients with non-Hodgkin lymphoma should generally be screened for HIV and hepatitis viruses. (msdmanuals.com)
- Also, patients with a first-degree relative with Hodgkin or non-Hodgkin lymphoma have an increased risk of non-Hodgkin lymphoma. (msdmanuals.com)
Follicular lymphoma2
- Follicular lymphoma international prognostic index. (medscape.com)
- non-follicular lymphoma (C83. (who.int)
Lymphocytes8
- They also commonly express cytotoxic T cell activation markers such as TIA1, granzyme B, and perforin and therefore may have derived from or be related to cytotoxic T cell lymphocytes. (wikipedia.org)
- They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation. (lookformedical.com)
- A classification of B-lymphocytes based on structurally or functionally different populations of cells. (lookformedical.com)
- Reduced expression of NFATassociated genes in UCB versus adult CD4+ lymphocytes during primary stimulation. (skinsurgerycenter.net)
- LyP histology is usually characterized by wedge-shaped cellular infiltrate that contains atypical large CD30+ lymphocytes. (nextstepsinderm.com)
- Lymphoma is any of a diverse group of cancers that originate in lymphocytes of the lymphatic system , a secondary (but open) circulatory system in vertebrates . (newworldencyclopedia.org)
- B cells are lymphocytes (a class of white blood cells ) that play a large role in the adaptive immune system by making antibodies to identify and neutralize invading pathogens like bacteria and viruses . (newworldencyclopedia.org)
- the remainder arise from T lymphocytes or natural killer cells. (msdmanuals.com)
CD3014
- Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)
- ALCL was recognized in 1985, when tumor cells consistently demonstrated labeling by the monoclonal antibody Ki-1, a marker later shown to recognize the CD30 antigen. (medscape.com)
- ADCETRIS is an antibody-drug conjugate (ADC) directed to CD30, a defining marker of cHL that is expressed on the surface of several types of lymphomas. (businesswire.com)
- Anaplastic lymphoma of the skin which develops as a primary neoplasm expressing the CD30 ANTIGEN . (nih.gov)
- CD30 is a transmembrane glycoprotein receptor of the tumor necrosis factor receptor super family 8 (TNFRSF8), mediating its effects through a number of signaling pathways that produce a survival advantage to the cells on which the protein is overexpressed. (aad.org)
- These 2 entities and their overlap cases make up the CD30-positive cutaneous lymphoproliferative disorders that represent about 25% of cutaneous T-cell lymphomas. (logicalimages.com)
- Despite the anaplastic cytomorphology of tumor cells that suggest an aggressive course, CD30(+) LPDs are characterized by an excellent prognosis. (qxmd.com)
- Brentuximab vedotin [12] consists of the chimeric monoclonal antibody brentuximab (cAC10, which targets the cell-membrane protein CD30 ) linked with maleimide attachment groups, cathepsin -cleavable linkers ( valine - citrulline ), and para-aminobenzylcarbamate spacers to three to five units of the antimitotic agent monomethyl auristatin E (MMAE, reflected by the 'vedotin' in the drug's name). (mdwiki.org)
- The antibody cAC10 part of the drug binds to CD30 which often occurs on diseased cells but rarely on normal tissues. (mdwiki.org)
- A CD30-directed antibody-drug conjugate called brentuximab vedotin is used to treat different lymphomas. (arkonsolution.com)
- A monoclonal antibody in the treatment for lymphoma known as brentuximab vedotin reacts to a protein known as CD30 on some lymphoma cells. (arkonsolution.com)
- To deliver medicine to the cell, brentuximab adheres to the CD30 protein. (arkonsolution.com)
- Vedotin is delivered via Brentuximab to target CD30 + cancer cells and kill them specifically. (arkonsolution.com)
- Patients with CD30-positive lymphoma who received stem cell transplantation may see better results while taking the brentuximab vedotin. (arkonsolution.com)
Lymphoproliferative disorder1
- I'll wager that most readers of DWI&I have experienced receiving a biopsy report, obtained from an inflammatory lesion, stating "scattered CD30+ cells were observed," accompanied by a comment that "clinicopathologic correlation is necessary to rule out the possibility of a lymphoproliferative disorder. (aad.org)
Type of non-Hodgkin'1
- a type of non-Hodgkin's lymphoma) in adult patients. (medlineplus.gov)
Hodgkin's6
- Martí-Carvajal AJ, Cardona AF, Lawrence A. Interventions for previously untreated patients with AIDS-associated non-Hodgkin's lymphoma. (medscape.com)
- Vitamin D insufficiency and prognosis in non-Hodgkin's lymphoma. (medscape.com)
- CTCLs belong to a larger group of disorders known as non-Hodgkin's lymphomas (NHLs). (patientworthy.com)
- A specific form of non-lymphoma Hodgkin's known as primary cutaneous anaplastic large cell lymphoma (pcALCL), among patients who have already undergone treatment. (arkonsolution.com)
- Hodgkin's lymphoma accounts for less than one percent of all cases of cancer in the United States. (newworldencyclopedia.org)
- These results serve as a rationale for ONC201 single-agent trials in relapsed/refractory acute leukemia, non-Hodgkin's lymphoma, MM and combination trial with dexamethasone in MM, provide pharmacodynamic biomarkers and identify further synergistic combinatorial regimens that can be explored in the clinic. (arizona.edu)
Stem cell transplant3
- To date, the best but still only marginally effective therapeutic interventions for the disease have been treatments that incorporate hematopoietic stem cell transplantation into chemotherapy plus surgical (when needed to treat local bowel issues such as obstruction or perforation) regimens. (wikipedia.org)
- Treatment includes chemotherapy and often stem cell transplantation , either from the patient's own bone marrow (autologous) or sometimes from another person's bone marrow (allogeneic). (dana-farber.org)
- With few exceptions, stem cell transplantation is usually reserved for patients with aggressive lymphomas after incomplete remission or relapse. (msdmanuals.com)
European-American Lymphoma2
- In 1988, ALCL was added as a distinct entity to the revised Kiel classification, and in 1994, it was included in the Revised European-American Lymphoma (REAL) classification. (medscape.com)
- It was based upon the "Revised European-American Lymphoma classification" (REAL). (newworldencyclopedia.org)
ALCL4
- Histologically, ALCL is characterized by sheets of large pleomorphic cells with abundant cytoplasm, horseshoe- or wreath-shaped nuclei, and multiple prominent nucleoli. (medscape.com)
- Ultimately, however, anaplastic large cell lymphoma (ALCL) was diagnosed. (cancernetwork.com)
- 156. "From Breast Implant to Rough Implant Associated-Anaplastic Large Cell Lymphoma (RIA-ALCL). (diepflap.it)
- ONC201 synergistically combined with bortezomib in MM, MCL and ALCL cells and with ixazomib or dexamethasone in MM cells. (arizona.edu)
World Health Organ3
- In 2008, the World Health Organization defined a specific type of lymphoma, enteropathy-associated T cell lymphoma (EATL), as having two different types: EATL type I, a lymphoma occurring in patients with the chronic, autoimmune GI tract disorder, celiac disease, and EATL type II, a similar bowel lymphoma that was not associated with celiac disease. (wikipedia.org)
- Consequently, the World Health Organization (2016) redefined these lymphomas as separate entities, terming the celiac disease-associated lymphoma as enteropathy-associted T cell lymphoma (EATL) and the lymphoma not associated with celiac disease as monomorphic epitheliotropic intestinal T cell lymphoma (MEITL). (wikipedia.org)
- The WHO Classification , published by the World Health Organization in 2001, is the latest classification of lymphoma (Sarkin 2001). (newworldencyclopedia.org)
Lymphoid3
- Lymphoid cells concerned with humoral immunity. (lookformedical.com)
- Extranodal lymphoma of lymphoid tissue associated with mucosa that is in contact with exogenous antigens. (lookformedical.com)
- Many of the sites of these lymphomas, such as the stomach, salivary gland, and thyroid, are normally devoid of lymphoid tissue. (lookformedical.com)
Types of lymphomas1
- The disease often occurs in elderly patients who are afflicted with other ailments and consequently have little tolerance for the standard chemotherapy regimens that are used to treat other types of lymphomas. (wikipedia.org)
Classification5
- http://www.ncbi.nlm.nih.gov/pubmed/17274935?tool=bestpractice.com [7] Raasch BA, Buettner PG, Garbe C. Basal cell carcinoma: histological classification and body-site distribution. (bmj.com)
- This classification divides NHL into two groups: those of B-cell origin and those of T-cell/natural killer (NK)-cell origin. (medscape.com)
- The WHO modification of the REAL classification of NHL is based on morphology and cell lineage. (medscape.com)
- Scientific classification of the types of lymphoma is more detailed. (newworldencyclopedia.org)
- This classification attempts to classify lymphomas by cell type (i.e. the normal cell type that most closely resembles the tumor). (newworldencyclopedia.org)
Intestinal T cell lym1
- The Organization (2016) also termed a third type of intestinal T cell lymphoma that could not be classified as ATL or MEITL as intestinal T cell lymphoma, not otherwise specified. (wikipedia.org)
Cancers3
- The Melanoma & Skin Center offers specialized treatment for patients with cutaneous T-cell lymphomas and other rare skin cancers. (mdanderson.org)
- It is those cancers that originate in the lymphatic system that are referred to as lymphomas. (newworldencyclopedia.org)
- Most non-Hodgkin lymphomas (NHL) in children are fast growing, aggressive cancers. (dana-farber.org)
Marginal1
- Inflammatory pseudotumour can simulate plasmacytoma and marginal zone B-cell lymphoma. (dermnetnz.org)
Proliferation3
- 6/7 primary cultures tested reduced proliferation, irrespective of prior RA signaling levels. (uni-wuerzburg.de)
- In vitro testing of primary tumor cultures provided clear evidence of a potential utility of retinoids in Wilms tumor treatment based on the analysis of gene expression, proliferation, differentiation and apoptosis. (uni-wuerzburg.de)
- While all these entities are characterized by proliferation of highly atypical, anaplastic CD30+ T cells, the expression of T-cell specific antigens in the tumor cells is not consistently detectable. (uni-wuerzburg.de)
Diagnosis4
- MEITL is a highly aggressive GI tract lymphoma which typically has had very short survival times following its diagnosis. (wikipedia.org)
- It cannot be overemphasized that the presence of CD30+ cells does not equate with neoplasia, in the same way that clonality does not confer the diagnosis of cancer. (aad.org)
- The diagnosis and differential diagnosis of 'small' B cell lymphomas. (llu.edu)
- A bone marrow smear was performed, in which 'cerebriform' cells were identified, confirming the diagnosis of Sézary syndrome. (bvsalud.org)
Patients5
- A cohort study comprised of 504 LyP patients found that there was an increased risk of developing nonhematologic malignancies such as squamous cell carcinoma (SCC), melanoma , bladder cancer , and lung cancer . (logicalimages.com)
- The primary aim is to determine a preliminary estimate of the progression-free survival of patients with T NHL who receive maintenance romidepsin at 2 years post-transplant for patients transplanted in CR1 or PR1 with standard risk histologies. (clinicaltrialsgps.com)
- Patients who receive romidepsin after transplant will be evaluable for the primary endpoint, and will be counted towards the accrual total. (clinicaltrialsgps.com)
- AA/Blacks comprised only 7%-8% 3,4 and 10% 5 of all CD30+ LPD patients included in these two large databases. (nextstepsinderm.com)
- Because the lymphatic system is part of the body's immune system , patients with weakened immune system, such as from HIV infection or from certain drugs or medication, also have a higher incidence of lymphoma. (newworldencyclopedia.org)
BURKITT LYMPHOMA1
- B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. (lookformedical.com)
Leukemia1
- Lymphoma Australia is the only incorporated charity in Australia dedicated to solely providing education, support, awareness and advocacy initiatives for Australians touched by lymphoma and chronic lymphocytic leukemia (CLL). (lymphoma.org.au)
Tumor cell4
- To search for possible modes of action of retinoids as novel therapeutic options, primary tumor cell cultures were treated in vitro with all-trans-RA (ATRA), 9cis-RA, fenretinide and combinations of retinoids and a histone deacetylase (HDAC) inhibitor. (uni-wuerzburg.de)
- If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely. (lookformedical.com)
- The peptide antibody-drug bond facilitates rapid and efficient drug cleavage inside target tumor cell. (mdwiki.org)
- ONC201 combined with bortezomib in a Burkitt's lymphoma xenograft model reduced tumor cell density and improved CHOP induction compared to either agent alone. (arizona.edu)
Antigen1
- absence/loss of pan B-cell and pan T-cell antigens), reactive cell population of other lineage, aberrant antigen expression, gene rearrangement studies, lineage infidelity, dual clones, and composite lymphomas. (aad.org)
Chemotherapy2
- Treatment for primary central nervous system lymphoma requires high doses of chemotherapy that enter the central nervous system, such as high-dose methotrexate and high-dose cytarabine. (dana-farber.org)
- Radiation therapy has been used as part of the treatment for this lymphoma in adults but may not be necessary if high dose chemotherapy is used in the treatment plan. (dana-farber.org)
Malignancies2
- Risk of second primary malignancies among cancer survivors in the United States, 1992 through 2008. (medscape.com)
- Although cutaneous lymphomas and internal malignancies are known associated conditions, the causative agents are unclear in most cases. (medicaljournals.se)
Lymphocyte2
- Specially, B cells play the major role in the humoral immune response , as opposed to the cell-mediated immune response that is governed by T cells , another type of lymphocyte. (newworldencyclopedia.org)
- Lymphocyte-like natural killer (NK) cells also are involved in the immune system , albeit part of the innate immune system . (newworldencyclopedia.org)
Monoclonal antibodies2
- Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. (clfoundation.org)
- Targeting specific proteins on the cell surface, monoclonal antibodies look for cancer cells. (arkonsolution.com)
Lymphocytic1
- Jessner's lymphocytic infiltrate can simulate chronic lymphocytic leukaemia , B cell type. (dermnetnz.org)
Mantle1
- The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1). (lookformedical.com)
Antigens1
- Sixty percent of cases express 1 or more T-cell antigens (CD3 + , CD43, or CD45RO). (medscape.com)
Genes5
- Microarray analysis of ATRA treated WT cells revealed differential expression of many genes involved in extracellular matrix formation and osteogenic, neuronal or muscle differentiation. (uni-wuerzburg.de)
- Furthermore, we identified the altered expression of 14 downstream target genes associated with inner ear development using patient-derived lymphoblastoid cell lines. (bvsalud.org)
- MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes. (dukecancerinstitute.org)
- green indicates genes that are overexpressed in normal cells compared to lymphoma cells and red indicates genes that are overexpressed in lymphoma cells compared to normal cells. (newworldencyclopedia.org)
- 150. "RNA Sequencing of Primary Cutaneous and Breast-Implant Associated Anaplastic Large Cell Lymphomas Reveals Infrequent Fusion Transcripts and Upregulation of PI3K/AKT Signaling via Neurotrophin Pathway Genes. (diepflap.it)