Maclura
Plant Lectins
Lectins
Phenylpropanoid glycosyltransferases from osage orange (Maclura pomifera) fruit. (1/4)
Flavonoids and isoflavonoids are well known for their beneficial effects on human health and their anti-insect and anti-microbial activities in plants. Osage orange fruit is rich in prenylated isoflavones and dihydrokaempferol and its glucoside. Four glycosyltransferases were identified from a collection of osage orange fruit expressed sequence tags. Biochemical characterization suggested that the glycosyltransferase UGT75L4 might be responsible for glucosylation of dihydrokaempferol in vivo, although this enzyme exhibited broad substrate recognition toward isoflavonoids and flavonoids in vitro. UGT88A4 was active on coumarin substrates. Identification of highly active phenylpropanoid glycosyltransferases will facilitate the metabolic engineering of glycosylated natural products in plants. (+info)Characterization of the secondary binding sites of Maclura pomifera agglutinin by glycan array and crystallographic analyses. (2/4)
(+info)Anti-metastatic effects on B16F10 melanoma cells of extracts and two prenylated xanthones isolated from Maclura amboinensis Bl roots. (3/4)
Inhibitory effects of Maclura amboinenesis Bl, one plant used traditionally for the treatment of cancers, on metastatic potential of highly metastatic B16F10 melanoma cells were investigated in vitro. Cell proliferation was assessed using the MTT colorimetric assay. Details of metastatic capabilities including invasion, migration and adhesion of B16F10 melanoma cells were examined by Boyden Chamber invasion and migration, scratch motility and cell attachment assays, respectively. The results demonstrated that n-hexane and chloroform extracts exhibited potent anti-proliferative effects (p<0.01), whereas the methanol and aqueous extracts had less pronounced effects after 24 h exposure. Bioactivity-guided chromatographic fractionation of both active n-hexane and chloroform extracts led to the isolation of two main prenylated xanthones and characterization as macluraxanthone and gerontoxanthone-I, respectively, their structures being identified by comparison with the spectral data. Interestingly, both exhibited potent effective effects. At non-toxic effective doses, n-hexane and chloroform extracts (10 and 30 mug/ml) as well as macluraxanthone and gerontoxanthone-I (3 and 10 muM) significantly inhibited B16F10 cell invasion, to a greater extent than 10 muM doxorubicin, while reducing migration of cancer cells without cellular cytotoxicity. Moreover, exposure of B16F10 melanoma cells to high concentrations of chloroform (30 mug/ml) and geratoxanthone-I (20 muM) for 24 h resulted in delayed adhesion and retarded colonization. As insights into mechanisms of action, typical morphological changes of apoptotic cells e.g. membrane blebbing, chromatin condensation, nuclear fragmentation, apoptotic bodies and loss of adhesion as well as cell cycle arrest in the G1 phase with increase of sub-G1 cell proportions, detected by Hoechst 33342 staining and flow cytometry were observed, suggesting DNA damage and subsequent apoptotic cell death. Taken together, our findings indicate for the first time that active n-hexane and chloroform extracts as well as macluraxanthone and gerontoxanthone-I isolated from Maclura amboinensis Bl. roots affect multistep of cancer metastasis processes including proliferation, adhesion, invasion and migration, possibly through induction of apoptosis of highly metastatic B16F10 melanoma cells. Based on these data, M. amboinensis Bl. represents a potential candidate novel chemopreventive and/or chemotherapeutic agent. Additionally, they also support its ethno-medicinal usage for cancer prevention and/or chemotherapy. (+info)HPLC determination of isoflavone levels in osage orange from the Midwest and southern United States. (4/4)
(+info)"Maclura" is a botanical term that refers to a genus of plants in the mulberry family (Moraceae). The most well-known species in this genus is Maclura pomifera, which is commonly known as the Osage orange or hedge apple. This tree is native to the southern United States and is known for its large, round, green fruits that are inedible but often used as decorations.
The wood of the Osage orange tree is very hard and durable, making it valuable for various purposes such as tool handles, fence posts, and archery bows. The tree also has a history of use in traditional medicine by Native American tribes, who have used various parts of the plant to treat ailments such as skin conditions, stomach problems, and fever. However, it is important to note that the safety and efficacy of using Maclura for medicinal purposes have not been thoroughly studied or proven through scientific research.
Plant lectins are proteins or glycoproteins that are abundantly found in various plant parts such as seeds, leaves, stems, and roots. They have the ability to bind specifically to carbohydrate structures present on cell membranes, known as glycoconjugates. This binding property of lectins is reversible and non-catalytic, meaning it does not involve any enzymatic activity.
Lectins play several roles in plants, including defense against predators, pathogens, and herbivores. They can agglutinate red blood cells, stimulate the immune system, and have been implicated in various biological processes such as cell growth, differentiation, and apoptosis (programmed cell death). Some lectins also exhibit mitogenic activity, which means they can stimulate the proliferation of certain types of cells.
In the medical field, plant lectins have gained attention due to their potential therapeutic applications. For instance, some lectins have been shown to possess anti-cancer properties and are being investigated as potential cancer treatments. However, it is important to note that some lectins can be toxic or allergenic to humans and animals, so they must be used with caution.
Lectins are a type of proteins that bind specifically to carbohydrates and have been found in various plant and animal sources. They play important roles in biological recognition events, such as cell-cell adhesion, and can also be involved in the immune response. Some lectins can agglutinate certain types of cells or precipitate glycoproteins, while others may have a more direct effect on cellular processes. In some cases, lectins from plants can cause adverse effects in humans if ingested, such as digestive discomfort or allergic reactions.
Maclura
Maclura cochinchinensis
Maclura pomifera
Maclura brasiliensis
Maclura tricuspidata
Maclura tinctoria
William Maclure
Flora of Malta
Paleobiota of the London Clay
Sericoplaga
1,2,3,4,5-Cyclopentanepentol
Pomiferin
List of food origins
Moraceae
Bathurst Showground
Phono-semantic matching
Arboretum du Grenouillet
Macluravirus
Wighteone
Parum
Protected areas of Malta
Moreae
Jacalin-like lectin domain
List of Southern African indigenous trees and woody lianes
Hambledon Cottage
Bois d'arc (disambiguation)
Fox squirrel
John J. Tyler Arboretum
Acremonium strictum
Ceratomia hageni
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Pomifera4
- Maclura pomifera (Raf. (theplantlist.org)
- Maclura pomifera agglutinin or lectin (MPA/MPL) is tetrameric plant protein isolated from Osage orange. (biotrend.com)
- CHERRY FOOD (cherry) injection, solution OSAGE ORANGE VAR BOIS DARC POLLEN (maclura pomifera pollen) injection, solution LAKE TROUT (trout) injection, solution TUNA injection, solution TURKEY FOOD (turkey) injection, solution BLACK WALNUT FOOD (black walnut) injection, solution [Allergy Laboratories, Inc. (nih.gov)
- I had actually made the marmalade out of Trifoliate orange (poncirus trifoliata), not Osage orange (maclura pomifera). (thegardenhelper.com)
Tricuspidata4
- Maclura tricuspidata (Syn. (wikipedia.org)
- Introducing the Cudrang, also known as Maclura tricuspidata in science. (worldnewsbuy.com)
- Maclura tricuspidata is also known by common names including cudrang, mandarin melon berry, silkworm thorn, zhe or che, and Chinese mulberry. (princeherb.com)
- Maclura tricuspidata is a tree native to East Asia, occasionally grown for its fruit, somewhat similar to that of the related mulberry. (princeherb.com)
Moraceae3
- Maclura is a genus of flowering plants in the mulberry family, Moraceae. (wikipedia.org)
- Some botanists recognize a more broadly defined Maclura that includes species previously included in Cudrania and other genera of Moraceae. (wikipedia.org)
- The genus Maclura is in the family Moraceae in the major group Angiosperms (Flowering plants) . (theplantlist.org)
Osage2
- Osage-orange (United States) Maclura pubescens (Syn. (wikipedia.org)
- The 75 "Aesculus" are broken down into buckeye trees, while the 70 "Maclura" are Osage orange trees. (keloland.com)
Tinctoria2
- Cudrania thorellii) (Cambodia, Vietnam) Maclura tinctoria (L.) D.Don ex Steud. (wikipedia.org)
- Maclura tinctoria (L.) D. Don ex Steud in Smithsonian Tropical Research Institute Tree Atlas (2022). (shadecoffee.org)
Cochinchinensis3
- Maclura africana (Africa) Maclura amboinensis (Myanmar to New Guinea) Maclura andamanica (Vietnam, Laos to Andaman Islands) Maclura brasiliensis (Brazil, Honduras, Nicaragua, Peru, and Venezuela) Maclura cochinchinensis (Syn. (wikipedia.org)
- Maclura cochinchinensis (Lour. (theplantlist.org)
- BACKGROUND AND AIMS: The purpose of this study was to investigate the biological properties of Kae-Lae (Maclura cochinchinensis (Lour. (bvsalud.org)
Genus3
- Maclura is closely related to the genus Cudrania, and hybrids between the two genera have been produced. (wikipedia.org)
- includes 89 scientific plant names of species rank for the genus Maclura . (theplantlist.org)
- includes a further 28 scientific plant names of infraspecific rank for the genus Maclura . (theplantlist.org)
Brasiliensis1
- Maclura brasiliensis (Mart. (theplantlist.org)
Spinosa2
- pubescens) (China) Maclura spinosa (India to Sri Lanka) Maclura thorellii (Syn. (wikipedia.org)
- Maclura spinosa (Roxb. (theplantlist.org)
20201
- Leading off the Château Pégau releases, the 2020 Côtes Du Rhône Cuvée Maclura has textbook southern France-like garrigue, leather, pepper, and both red and black fruits in a medium-bodied, nicely balanced, charming style. (toastwines.com)
Africana1
- Maclura africana (Africa) Maclura amboinensis (Myanmar to New Guinea) Maclura andamanica (Vietnam, Laos to Andaman Islands) Maclura brasiliensis (Brazil, Honduras, Nicaragua, Peru, and Venezuela) Maclura cochinchinensis (Syn. (wikipedia.org)
Aurantiaca1
- Comparaison des diastases hydrolysantes du latex de Maclura aurantiaca avec celles de Ficus carica et de Broussonetia papyrifera. (nih.gov)
Amboinensis1
- 11. Anti-metastatic effects on B16F10 melanoma cells of extracts and two prenylated xanthones isolated from Maclura amboinensis Bl roots. (nih.gov)
Broussonetia1
- Milicia excelsa (as Maclura excelsa) Milicia regia (as Maclura regia) Broussonetia greveana (as Maclura greveana and Maclura humbertii) Fossils similar to Maclura have been reported from the Middle Eocene of England. (wikipedia.org)
Family1
- Whether you are looking for a romantic getaway or a family vacation, the Maclura Residence is the perfect destination. (maldives-times.com)
Main1
- The main restaurant, called "The Maclura", offers a range of international and Maldivian dishes. (maldives-times.com)
China1
- pubescens) (China) Maclura spinosa (India to Sri Lanka) Maclura thorellii (Syn. (wikipedia.org)