Greatly exaggerated width of the mouth, resulting from failure of union of the maxillary and mandibular processes, with extension of the oral orifice toward the ear. The defect may be unilateral or bilateral. (Dorland, 27th ed)
A family of GLYCOSYLPHOSPHATIDYLINOSITOL-anchored, cell-surface heparan sulfate proteoglycans that may play a role in CELL GROWTH PROCESSES and CELL DIFFERENTIATION by modulating ligand-receptor interactions.
The condition of accelerated and excessive GROWTH in children or adolescents who are exposed to excess HUMAN GROWTH HORMONE before the closure of EPIPHYSES. It is usually caused by somatotroph hyperplasia or a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. These patients are of abnormally tall stature, more than 3 standard deviations above normal mean height for age.
NATIONAL LIBRARY OF MEDICINE service for health professionals and consumers. It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions.
Ubiquitous macromolecules associated with the cell surface and extracellular matrix of a wide range of cells of vertebrate and invertebrate tissues. They are essential cofactors in cell-matrix adhesion processes, in cell-cell recognition systems, and in receptor-growth factor interactions. (From Cancer Metastasis Rev 1996; 15(2): 177-86; Hepatology 1996; 24(3): 524-32)
The presence of an excessively large tongue, which may be congenital or may develop as a result of a tumor or edema due to obstruction of lymphatic vessels, or it may occur in association with hyperpituitarism or acromegaly. It also may be associated with malocclusion because of pressure of the tongue on the teeth. (From Jablonski, Dictionary of Dentistry, 1992)
A characteristic symptom complex.
'Abnormalities, Multiple' is a broad term referring to the presence of two or more structural or functional anomalies in an individual, which may be genetic or environmental in origin, and can affect various systems and organs of the body.

Ultrasound prenatal diagnosis of a lateral facial cleft (Tessier number 7). (1/3)

Lateral facial clefting may occur as an isolated phenomenon or in association with other disorders. It may originate from a failed penetration of ectomesenchyme between the developing maxillary and mandibular prominences, but disruptive factors may also occur in a proportion of cases. The frequency of this abnormality is estimated as 1 in 50 000-175 000 live births. We describe a case of isolated symmetrical lateral facial cleft (number 7 according to the Tessier classification) diagnosed prenatally on ultrasound examination at 26 weeks of gestation.  (+info)

Bilateral transverse facial cleft as an isolated deformity: case report. (2/3)

Transverse facial clefts are rare deformities, these mostly occur as part of syndromes such as facial dysostosis and branchial arch syndrome. This is a report of a case of isolated, asyndromic bilateral facial cleft seen at a semi-urban specialist hospital. Congenital facial defects remain sources of mental and social stress to the families. Infanticide, perhaps a thing of the past in the developed world may still be practiced in cases of congenital deformities in the developing countries, hence the need for early involvement of social workers and clinical psychologist in management.  (+info)

Ablepharon macrostomia syndrome. (3/3)

The association of congenital ablepharon with the absence of eyelashes and eyebrows, a wide mouth (macrostomia), and auricular, nasal, genital, and other systemic anomalies has been termed the ablepharon macrostomia syndrome. One such case is reported which illustrates the importance of immediate postnatal ocular management to minimise severe visual loss.  (+info)

Macrostomia is a relatively rare medical condition characterized by an abnormally large or wide mouth opening. This condition can be congenital, meaning it is present at birth, or acquired later in life due to various factors such as trauma, nerve damage, or certain muscular disorders. In some cases, macrostomia may simply be a cosmetic concern, but in other instances, it can lead to complications such as speech difficulties, problems with eating and drinking, or an increased risk of oral infections. Treatment for macrostomia typically involves surgical intervention to reduce the size of the mouth opening and improve function and appearance.

Glypicans are a type of heparan sulfate proteoglycan (HSPG) that are attached to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor. They are involved in various biological processes, such as cell growth, differentiation, and migration, by regulating the distribution and activity of various signaling molecules, including morphogens, growth factors, and Wnt proteins. There are six distinct glypican genes (GPC1-6) identified in humans, each encoding a unique protein isoform with a conserved core structure but varying in their specific functions and expression patterns. Abnormal glypican expression or function has been implicated in several diseases, including cancer, developmental disorders, and neurodegenerative diseases.

Gigantism is a rare medical condition characterized by excessive growth and height significantly above average. This occurs due to an overproduction of growth hormone (GH), also known as somatotropin, during the growth phase in childhood. The pituitary gland, a small gland located at the base of the brain, is responsible for producing this hormone.

In gigantism, the pituitary gland releases too much GH, leading to abnormal bone and tissue growth. This condition is different from acromegaly, which is characterized by excessive GH production in adulthood after the growth phase has ended. In both cases, the excess GH can lead to various health complications, including cardiovascular disease, diabetes, hypertension, and joint problems.

Gigantism is typically caused by a benign tumor called a pituitary adenoma that presses against and stimulates the production of GH from the anterior pituitary gland. Treatment usually involves surgical removal of the tumor or medication to control GH levels, depending on the severity and progression of the condition. Early diagnosis and treatment are crucial for managing the symptoms and preventing long-term health complications associated with gigantism.

MedlinePlus is not a medical term, but rather a consumer health website that provides high-quality, accurate, and reliable health information, written in easy-to-understand language. It is produced by the U.S. National Library of Medicine, the world's largest medical library, and is widely recognized as a trusted source of health information.

MedlinePlus offers information on various health topics, including conditions, diseases, tests, treatments, and wellness. It also provides access to drug information, medical dictionary, and encyclopedia, as well as links to clinical trials, medical news, and patient organizations. The website is available in both English and Spanish and can be accessed for free.

Heparan sulfate proteoglycans (HSPGs) are complex molecules composed of a core protein to which one or more heparan sulfate (HS) glycosaminoglycan chains are covalently attached. They are widely distributed in animal tissues and play crucial roles in various biological processes, including cell-cell communication, growth factor signaling, viral infection, and cancer metastasis.

The HS chains are long, linear polysaccharides composed of repeating disaccharide units of glucosamine and uronic acid (either glucuronic or iduronic acid). These chains contain sulfate groups at various positions, which give them a negative charge and allow them to interact with numerous proteins, growth factors, and enzymes.

HSPGs can be found on the cell surface (syndecans and glypicans) or in the extracellular matrix (perlecans and agrin). They act as co-receptors for many signaling molecules, such as fibroblast growth factors (FGFs), wingless-type MMTV integration site family members (WNTs), and hedgehog proteins. By modulating the activity of these signaling pathways, HSPGs help regulate various cellular functions, including proliferation, differentiation, migration, and adhesion.

Dysregulation of HSPGs has been implicated in several diseases, such as cancer, fibrosis, and viral infections (e.g., HIV and herpes simplex virus). Therefore, understanding the structure and function of HSPGs is essential for developing new therapeutic strategies to target these diseases.

Macroglossia is a medical term that refers to an abnormally large tongue in relation to the size of the oral cavity. It can result from various conditions, including certain genetic disorders (such as Down syndrome and Beckwith-Wiedemann syndrome), hormonal disorders (such as acromegaly), inflammatory diseases (such as amyloidosis), tumors or growths on the tongue, or neurological conditions. Macroglossia can cause difficulties with speaking, swallowing, and breathing, particularly during sleep. Treatment depends on the underlying cause but may include corticosteroids, radiation therapy, surgery, or a combination of these approaches.

A syndrome, in medical terms, is a set of symptoms that collectively indicate or characterize a disease, disorder, or underlying pathological process. It's essentially a collection of signs and/or symptoms that frequently occur together and can suggest a particular cause or condition, even though the exact physiological mechanisms might not be fully understood.

For example, Down syndrome is characterized by specific physical features, cognitive delays, and other developmental issues resulting from an extra copy of chromosome 21. Similarly, metabolic syndromes like diabetes mellitus type 2 involve a group of risk factors such as obesity, high blood pressure, high blood sugar, and abnormal cholesterol or triglyceride levels that collectively increase the risk of heart disease, stroke, and diabetes.

It's important to note that a syndrome is not a specific diagnosis; rather, it's a pattern of symptoms that can help guide further diagnostic evaluation and management.

'Abnormalities, Multiple' is a broad term that refers to the presence of two or more structural or functional anomalies in an individual. These abnormalities can be present at birth (congenital) or can develop later in life (acquired). They can affect various organs and systems of the body and can vary greatly in severity and impact on a person's health and well-being.

Multiple abnormalities can occur due to genetic factors, environmental influences, or a combination of both. Chromosomal abnormalities, gene mutations, exposure to teratogens (substances that cause birth defects), and maternal infections during pregnancy are some of the common causes of multiple congenital abnormalities.

Examples of multiple congenital abnormalities include Down syndrome, Turner syndrome, and VATER/VACTERL association. Acquired multiple abnormalities can result from conditions such as trauma, infection, degenerative diseases, or cancer.

The medical evaluation and management of individuals with multiple abnormalities depend on the specific abnormalities present and their impact on the individual's health and functioning. A multidisciplinary team of healthcare professionals is often involved in the care of these individuals to address their complex needs.

Classifications are a complete lateral facial cleft, simple macrostomia, macrostomia with diastasis of the facial musculature, ... Macrostomia refers to a mouth that is unusually wide. The term is from the Greek prefix makro- meaning "large" and from Greek ... This version of macrostomia is less severe because it does not affect the facial muscles and is not associated with any soft ... It's unusual for macrostomia to occur on its own and it is included as a symptom for many diseases including craniofacial ...
"Ablepharon macrostomia syndrome". Global Genes. Retrieved 2019-12-13. "Ablepharon-Macrostomia Syndrome , Hereditary Ocular ... Macrostomia, the wide, fish-like mouth, can be corrected by a maxillofacial surgeon. The skin can be treated by means of creams ... Ablepharon macrostomia syndrome (AMS) is an extremely rare, autosomal dominant genetic disorder characterized by abnormal ... Ablepharon macrostomia syndrome can be diagnosed at birth by identification of characteristic physical findings, clinical ...
Teebi, A. S. (1991-03-15). "Trigonobrachycephaly, bulbous bifid nose, macrostomia, micrognathia, acral anomalies, and hypotonia ... macrostomia, thin upper lip, macrognathia (facial dysmorphisms), broad thumbs, rather large toes, broad fingertips with short ...
One sibling appeared to have a lethal form of ablepharon-macrostomia syndrome (AMS; 200110) or an intermediate phenotype ... Cavalcanti DP, Matejas V, Luquetti D, Mello MF, Zenker M (February 2007). "Fraser and Ablepharon macrostomia phenotypes: ...
"Recurrent Mutations in the Basic Domain of TWIST2 Cause Ablepharon Macrostomia and Barber-Say Syndromes". The American Journal ... DNA-binding activity through both dominant-negative and gain-of-function effects are associated with ablepharon macrostomia ...
... macrostomia). Barber-Say syndrome is phenotypically similar to Ablepharon macrostomia syndrome, which is also associated with ... July 2015). "Recurrent Mutations in the Basic Domain of TWIST2 Cause Ablepharon Macrostomia and Barber-Say Syndromes". American ... including macrostomia Eyelid deformities Abnormal and low-set ears Bulbous nasal tip with hypoplastic alae nasi Low frontal ...
"A susceptibility locus on 1p32-1p34 for congenital macrostomia in a Chinese family and identification of a novel PTCH2 mutation ... and susceptibility to congenital macrostomia. GRCm38: Ensembl release 89: ENSMUSG00000028681 - Ensembl, May 2017 "Human PubMed ...
... macrostomia). Skeletal deformities include scoliosis and mild epiphyseal changes in the first bones of the fingers (proximal ...
Ablepharon macrostomia syndrome : (AMS) A rare genetic disorder characterized by various physical anomalies which affect the ...
Features related to TCS that are seen less frequently include nasal deformities, high-arched palate, macrostomia, preauricular ...
... see Altered level of consciousness Antimicrobial stewardship Ablepharon macrostomia syndrome, an autosomal dominant genetic ...
... macrostomia MeSH C07.465.525.520 - microstomia MeSH C07.465.525.955 - velopharyngeal insufficiency MeSH C07.465.550.425 - jaw, ... macrostomia MeSH C07.650.525.520 - microstomia MeSH C07.650.525.955 - velopharyngeal insufficiency MeSH C07.650.800.065 - ...
... of neck 744.8 Other specified congenital anomalies of face and neck 744.81 Macrocheilia 744.82 Microcheilia 744.83 Macrostomia ...
Abderhalden-Kaufmann-Lignac syndrome Abdominal compartment syndrome abdominal wall pain syndrome Ablepharon macrostomia ...
... macrostomia, vaulted palate, malformations of both the external and internal ear, buccal-auricular fistula, abnormal ...
... macrostomia MeSH C16.131.850.525.520 - microstomia MeSH C16.131.850.525.955 - velopharyngeal insufficiency MeSH C16.131.850.800 ...
... macrostomia, severe underdevelopment of the clitoris, and down-facing corners of the mouth. Radiological findings included a ...
Hyperthyroidism Hyperthyroidism due to mutations in TSH receptor Hypertrichosis atrophic skin ectropion macrostomia ...
Abdominal neoplasms Aberrant subclavian artery Ablepharon macrostomia syndrome Abnormal systemic venous return Abruzzo-Erickson ...
Severe intellectual disability Psychomotor retardation Epilepsy Psoriasis Hypertelorism Broad nose Anteverted eyes Macrostomia ...
Classifications are a complete lateral facial cleft, simple macrostomia, macrostomia with diastasis of the facial musculature, ... Macrostomia refers to a mouth that is unusually wide. The term is from the Greek prefix makro- meaning "large" and from Greek ... This version of macrostomia is less severe because it does not affect the facial muscles and is not associated with any soft ... Its unusual for macrostomia to occur on its own and it is included as a symptom for many diseases including craniofacial ...
The ablepharon-macrostomia syndrome is a very rare condition caused by a dominant mutation in the TWIST2 gene. Congenital ... Long-term results of the surgical management of the upper eyelids in Ablepharon- Macrostomia syndrome. Cruz AA, Quiroz D, ... defects include rudimentary eyelids, macrostomia, ambiguous genitalia and campodactyly. Neonates are at risk of severe corneal ...
Macrostomia is a rare congenital anomaly, defined as extending from the mouth in the region of the oral commissure. Can be ... Case Report: The objective of this study is to present a clinical case of a 3-year-old patient with bilateral macrostomia. ... Conclusion: Macrostomia is a congenital anomaly that requires surgical treatment. The closing straight line presented good ... Surgical treatment of Macrostomia. Rev. cir. traumatol. buco-maxilo-fac. [online]. 2016, vol.16, n.4, pp. 26-29. ISSN 1808-5210 ...
an unusually large mouth (macrostomia. ), a large tongue (macroglossia. ) that may have a deep groove or furrow. down the ...
Ablepharon-Macrostomia Syndrome Also known as: AMS NORD Rare Disease Report Acanthocheilonemiasis Also known as: ...
Isolated Macrostomia with Bilateral Facial Cleft in a Preterm Neonate. Raghavendra, Prashanth Ranya; Nair, Sruthi; ...
This is associated with macrostomia and is similar to a subcutaneous cleft. The texture of the skin in this area is different ... Differential diagnoses include Nager syndrome and ablepharon macrostomia syndrome. The syndrome may be due to problems of ...
ablepharon macrostomia syndrome Abruzzo-Erickson syndrome Abuse Dwarfism Syndrome aceruloplasminemia achalasia microcephaly ...
This is associated with macrostomia and is similar to a subcutaneous cleft. The texture of the skin in this area is different ... Differential diagnoses include Nager syndrome and ablepharon macrostomia syndrome. The syndrome may be due to problems of ...
Ablepharon-macrostomia syndrome. Stevens CA, Sargent LA. Ablepharon-macrostomia syndrome. Am J Med Genet. 2002 Jan 1;107(1):30- ... Macrostomia and thin lips with redundant facial skin are often evident. The nose appears bulbous. The thoracic skin can be ... Recurrent Mutations in the Basic Domain of TWIST2 Cause Ablepharon Macrostomia and Barber-Say Syndromes. Marchegiani S, Davis T ... TWIST2 mutations have also been found in Setleis syndrome (227260) and in ablepharon-macrostomia syndrome (200110). These ...
... research as a management group and so they participated in only test classes and didnt macrostomia, tags) (76%); d) different ...
... macrostomia, cervical vertebral anomalies and congenital heart disease (1). An accessory tragus is consistently found in ...
Surgical Correction of Cleft Lip Accompanied with Macrostomia: Case Report. Nyoman Ayu Anggayanti , Harmas Yazid Yusuf [11] , ...
Macrostomia Macrostomias use Macrostomia Macrotinum Macrouridae use Gadiformes Macroxyproteinase use Proteasome Endopeptidase ...
Macrostomias use Macrostomia Macrotinum Macrotys racemosa use Cimicifuga Macrouridae use Gadiformes Macroxyproteinase use ...
Macrostomias use Macrostomia Macrotinum Macrotys racemosa use Cimicifuga Macrouridae use Gadiformes Macroxyproteinase use ...
Macrostomias use Macrostomia Macrotinum Macrotys racemosa use Cimicifuga racemosa Macrouridae use Gadiformes ...
Macrostomias use Macrostomia Macrotinum Macrotys racemosa use Cimicifuga Macrouridae use Gadiformes Macroxyproteinase use ...
香港兔唇裂顎協會 是本港唯一一個專為唇顎裂患兒/患者和
Q18.4) Macrostomia. *(Q18.5) Microstomia. *(Q18.6) Macrocheilia. *(Q18.7) Microcheilia. *(Q18.8) Other specified congenital ...
... shrunken and misplaced ear as well as a type of cleft lip called macrostomia, where the left corner of the lip doesnt end at ...
ID: DOID:5602 Type: http://bio2vec.net/ontology/disease Label: T-cell adult acute lymphocytic leukemia Synonyms: T-cell adult acute lymphocytic leukemia Alternative IDs: als API: GO SPARQL: GO ...
Ablepharon-macrostomia Syndrome. Anotia and Microtia. These are two similar birth defects with certain differences. If an ...
ablepharon-macrostomia syndrome. Corresponding gene TWIST2 Other symbol(s) AMS Main clinical features * congenital ectodermal ... absent hair, brows, and lashes, absent or short eyelids, macrostomia, ear anomalies, redundant skin, and abnormal genitalia ... dysplasia characterized by absent eyelids, macrostomia, microtia, redundant skin, sparse hair, dysmorphic nose and ears, ...
Phenotype data for mouse gene Isl1. Discover Isl1s significant phenotypes, expression, images, histopathology and more. Data for gene Isl1 is all freely available for download.
A knowledge graph of biological entities such as genes, gene functions, diseases, phenotypes and chemicals. Embeddings are generated with Walking RDF and OWL method ...
Ablepharon macrostomia syndrome. Ablepharon-macrostomia syndrome (AMS) is a congenital ectodermal dysplasia characterized by ... absent eyelids, macrostomia, microtia, redundant skin, sparse hair, dysmorphic nose and ears, variable abnormalities of the ...
Ablepharon-macrostomia syndrome (AMS) is a congenital ectodermal dysplasia characterized by absent eyelids, macrostomia, ... Ablepharon macrostomia syndrome. MedGen UID: 395439. •Concept ID: C1860224. •. Disease or Syndrome. ...
Ablepharon-macrostomia syndrome (TWIST2). *Acampomelic campomelic dysplasia (SOX9). *Acrodysostosis 2, with/-out hormone ...
Subjects: MACROSTOMIA (ETIOLOGIA), FENÓTIPOS, TOMOGRAFIA. A citação é gerada automaticamente e pode não estar totalmente de ... Subjects: MACROSTOMIA, ANOMALIA CRANIOFACIAL, DISOSTOSE MANDIBULOFACIAL, ASSIMETRIA FACIAL. A citação é gerada automaticamente ... Macrostomia: A Spectrum of Deformity (2014). Buonocore, Samuel; Broer, P. Niclas; Walker, Marc E.; Freitas, Renato da Silva; ... Macrostomia: A Spectrum of Deformity. Annals of Plastic Surgery, v. 72, n. 5, p. 363-368, 2014Tradução . . Disponível em: https ...
  • The ablepharon-macrostomia syndrome is a very rare condition caused by a dominant mutation in the TWIST2 gene. (thepmfajournal.com)
  • Long-term results of the surgical management of the upper eyelids in 'Ablepharon'- Macrostomia syndrome. (thepmfajournal.com)
  • McCarthy GT, West CM (1977) Ablepharon macrostomia syndrome. (altmeyers.org)
  • Stevens CA, Sargent LA (2002) Ablepharon-macrostomia syndrome. (altmeyers.org)
  • Congenital defects include rudimentary eyelids, macrostomia, ambiguous genitalia and campodactyly. (thepmfajournal.com)
  • Macrostomia is a rare congenital anomaly, defined as extending from the mouth in the region of the oral commissure. (bvsalud.org)
  • Conclusion: Macrostomia is a congenital anomaly that requires surgical treatment. (bvsalud.org)
  • It is associated with abnormalities of first and second brachial arches and is characterized by unilateral or bilateral microtia/anotia/atresia, preauricular tags, facial tags, conductive hearing loss, epidermal lipodermoids, microphthalmia, mandibular hypoplasia, maxillary hypoplasia, macrostomia, cervical vertebral anomalies and congenital heart disease (1). (pediatriconcall.com)
  • Yesterday, Amanda operated on a boy with hemifacial microsomia, a congenital condition which left him with a misshapen, shrunken and misplaced ear as well as a type of cleft lip called macrostomia, where the left corner of the lip doesn't end at it's usual location and instead extends out on to the cheek towards the ear, making it difficult for the child to eat. (blogs.com)
  • Classifications are a complete lateral facial cleft, simple macrostomia, macrostomia with diastasis of the facial musculature, and isolated facial musculature diastasis. (wikipedia.org)
  • The cleft associated with macrostomia is associated with improper or failed fusion of the mandibular and maxillary processes during embryonic development. (wikipedia.org)
  • Surgical treatments included: correction of macrostomia, distraction osteogenesis, staged ear reconstruction, orbit-maxillary-mandibular surgery, soft tissue reconstruction with dermis fat graft, vascularized free tissue transfer, cleft lip-cleft lip nose repair and palatoplasty. (jmatonline.com)
  • Macrostomia refers to a mouth that is unusually wide. (wikipedia.org)
  • This version of macrostomia is less severe because it does not affect the facial muscles and is not associated with any soft tissue or bone deformities. (wikipedia.org)
  • Clefts in this variant are slightly more severe than the ones seen in simple macrostomia. (wikipedia.org)
  • A rare genetic intellectual disability malformation syndrome characterized by global developmental delay intellectual disability delayed speech and language development epilepsy autistic behavior and moderate facial dysmorphism (including elongated face narrow forehead arched eyebrows horizontal palpebral fissures hypertelorism epicanthus midface flattening short nose long and featureless philtrum thin upper lip macrostomia and prominent chin). (globalgenes.org)
  • Case Report: The objective of this study is to present a clinical case of a 3-year-old patient with bilateral macrostomia. (bvsalud.org)
  • Macrostomia is characterized as a physical abnormality that causes clefts to form on the face of affected individuals. (wikipedia.org)
  • PTCH2 (Val147Ile) is a loss of function mutation which results in a lack of control of cell growth during development and links it to macrostomia. (wikipedia.org)
  • The main problems associated with macrostomia are cosmetic changes and difficulties in swallowing and speech. (bvsalud.org)
  • We report three new cases of ablepharon-macrostomia syndrome (AMS) and give a 10-year follow-up on a newborn reported in an abstract. (nih.gov)
  • Evidence for autosomal dominant inheritance of ablepharon-macrostomia syndrome. (nih.gov)
  • Case report supporting that the Barber-Say and ablepharon macrostomia syndromes could represent one disorder. (nih.gov)
  • Ablepharon-macrostomia syndrome: first report of familial occurrence. (nih.gov)
  • The ablepharon-macrostomia syndrome is a very rare condition caused by a dominant mutation in the TWIST2 gene. (thepmfajournal.com)
  • Long-term results of the surgical management of the upper eyelids in 'Ablepharon'- Macrostomia syndrome. (thepmfajournal.com)
  • Despite being visually impaired due to a rare syndrome called Ablepharon-Macrostomia, she is set to graduate from Hackensack Meridian School of Medicine. (einsteinmed.edu)
  • Jaw Joint Surgery and Scar Revision for Facial Asymmetry Correction A 7-year-old girl from Hubbali, Karnataka, India had grade III hemifacial microsomia and macrostomia when she was born, which made it hard for her left lower jaw to grow. (smbalaji.com)
  • Case Report: The objective of this study is to present a clinical case of a 3-year-old patient with bilateral macrostomia. (bvsalud.org)
  • Macrostomia can be partially classified as a heritable autosomal dominant disease. (wikipedia.org)
  • This version of macrostomia is less severe because it does not affect the facial muscles and is not associated with any soft tissue or bone deformities. (wikipedia.org)