Characterisation of marrubenol, a diterpene extracted from Marrubium vulgare, as an L-type calcium channel blocker. (1/4)
1. The objective of the present study was to investigate the mechanism of the relaxant activity of marrubenol, a diterpenoid extracted from Marrubium vulgare. In rat aorta, marrubenol was a more potent inhibitor of the contraction evoked by 100 mM KCl (IC50: 11.8+/-0.3 microM, maximum relaxation: 93+/-0.6%) than of the contraction evoked by noradrenaline (maximum relaxation: 30+/-1.5%). 2. In fura-2-loaded aorta, marrubenol simultaneously inhibited the Ca2+ signal and the contraction evoked by 100 mM KCl, and decreased the quenching rate of fura-2 fluorescence by Mn2+. 3. Patch-clamp data obtained in aortic smooth muscle cells (A7r5) indicated that marrubenol inhibited Ba2+ inward current in a voltage-dependent manner (KD: 8+/-2 and 40+/-6 microM at holding potentials of -50 and -100 mV, respectively). 4. These results showed that marrubenol inhibits smooth muscle contraction by blocking L-type calcium channels. (+info)The in-vitro evaluation of antibacterial, antifungal and cytotoxic properties of Marrubium vulgare L. essential oil grown in Tunisia. (2/4)
(+info)Molluscicidal and Mosquitocidal activities of the essential oils of Thymus capitatus Hoff. et Link. and Marrubium vulgare L. (3/4)
(+info)Antiproliferative activity of Marrubium persicum extract in the MCF-7 human breast cancer cell line. (4/4)
AIM: Developing antitumor drugs from natural products is receiving increasing interest worldwide due to limitations and side effects of therapy strategies for the second leading cause of disease related mortality, cancer. METHODS: The antiproliferative activity of a methanolic extract from the aerial parts of Marrubium persicum extract was assessed with the MCF-7 breast cancer cell line using the MTT test for cell viability and cytotoxicity indices. In addition, antioxidant properties of the extract were evaluated by measuring its ability to scavenge free DPPH radicals. Moreover, the total phenolic and flavonoid content of the extract was determined based on Folin-Ciocalteu and colorimetric aluminum chloride methods. RESULTS: The findings of the study for the antiproliferative activity of the methanolic extract of M. persicum showed that growth of MCF-7 cells was inhibited by the extract in a dose and time dependent manner, where a gradual increase of cytotoxicity effect has been achieved setting out on 200 mug/mL concentration of the plant extract. The antioxidant assay revealed that the extract was a strong scavenger of DPPH radicals with an RC50 value of 52 mug/mL. The total phenolic and flavonoids content of the plant extract was 409.3 mg gallic acid equivalent and 168.9 mg quercetin equivalent per 100g of dry plant material. CONCLUSION: Overall, M. persicum possesses potential antiproliferative and antioxidant activities on the malignant MCF-7 cell line that could be attributed to the high content of phenolics and flavonoids, and therefore warrants further exploration. (+info)'Marrubium' is a genus of plants in the mint family, Lamiaceae, which includes several species commonly known as horehound, characterized by their hairy leaves and white or pink flowers, and having medicinal uses, particularly for treating respiratory ailments.
"Marrubium" is the genus name of a group of plants in the mint family, Lamiaceae. It includes several species commonly known as horehound, which are native to Europe and Central Asia. The leaves and stems of these plants contain various compounds with potential medicinal properties, such as diterpene bitters, flavonoids, and phenolic acids. Horehound has been traditionally used in herbal medicine to treat coughs, colds, and respiratory ailments. However, it's important to note that the effectiveness of horehound for these uses is not well-established by scientific research, and it can interact with certain medications. Therefore, it should be used under the guidance of a healthcare provider.
Marrubium - Wikipedia
Turkey Marrubium vanense Hub.-Mor. - Turkey Marrubium velutinum Sm. - Greece Marrubium vulcanicum Hub.-Mor. - Turkey Marrubium ... Noë - Turkey Marrubium cordatum Nábelek - Iran, Iraq, Turkey Marrubium crassidens Boiss. - Iran, Iraq Marrubium cuneatum Banks ... Caucasus Marrubium procerum Bunge - Iran Marrubium propinquum Fisch. & C.A.Mey. - Iran, Caucasus Marrubium rotundifolia Boiss ... Morocco Marrubium ayardii Maire - Morocco Marrubium × bastetanum Coincy - Spain (M. supinum × M. vulgare) Marrubium bourgaei ...
ALPAFLOR® MARRUBIUM AO
... sustainable plant extract from Marrubium vulgare. Proven in vitro to reduce histamine production, this alpine extract protects ... ALPAFLOR® MARRUBIUM AO is an organic, sustainable plant extract from Marrubium vulgare. Proven in vitro to reduce histamine ... ALPAFLOR® MARRUBIUM AO Safety Data Sheet. SAFETY DATA SHEET for the natural and organic certified cosmetic ingredient ALPAFLOR ...
UCJEPS: Jepson Interchange: Marrubium vulgare L.
Marrubium vulgare
View Calflora record for Marrubium vulgare*View all photos in CalPhotos of Marrubium vulgare *Check Google Images for Marrubium ... Marrubium vulgare Photographer: Steve Matson. ID: 0000 0000 0808 1399 (2008-08-20). Copyright © 2008 Steve Matson. ... The photographers identification Marrubium vulgare has not been reviewed. Click here to review or comment on the ...
Marrubium alysson
View all photos in CalPhotos of Marrubium alysson *Check Google Images for Marrubium alysson ... Marrubium alysson Photographer: Luigi Rignanese. ID: 0000 0000 0407 1472 (2007-04-16). Copyright © 2007 Luigi Rignanese. ... The photographers identification Marrubium alysson has not been reviewed. Click here to review or comment on the ...
SEINet Portal Network - Marrubium vulgare
Duration: Perennial Nativity: Non-Native Lifeform: Subshrub General: Perennial exotic herb from a taproot; stems several, prostrate to ascending-erect, 20-100 cm long/tall, densely white wooly. Leaves: Opposite, blades 1-6 cm long, conspicuously wrinkled, ovate to round, with crenate margins; generally green and pubescent above, white wooly below. Flowers: Whorled in globular clusters in leaf axils, with spiny calyces; corolla 5-10 mm long, whitish. Fruits: 4 nutlets Ecology: On disturbed ground from 2,000-7,500 ft (610-2285 m); flowers April-October. Distribution: Introduced to N. Amer., except Alberta, Manitoba, ND, LA and FL ; south to S. Amer.; throughout the world on every continent. Notes: Distinguished by pungent-smelling, noticeably wrinkly, thick soft leaves and white-wooly pubescence on the whitish stems and undersides of leaves; and the inflorescences in verticils surrounding stems in dense clusters. This introduced perennial can form dense stands at mid-elevations in disturbed areas. ...
Marrubium vulgare Invasive Plant - California Invasive Plant Council
Marrubium "All Hallows Green" - Cactus Jungle
Marrubium sericeum Boiss.
This name is a synonym of Marrubium supinum L. by Lamiaceae. The record derives from WCSP (data supplied on 2022-04-20) which ... Cite taxon page as WFO (2023): Marrubium sericeum Boiss. Published on the Internet;http://www.worldfloraonline.org/taxon/wfo- ... Cite taxon page as WFO (2023): Marrubium sericeum Boiss. Published on the Internet;. http://www.worldfloraonline.org/taxon/wfo ...
Günther's Site - Photos of European Plants - Marrubium peregrinum
5: Marrubium peregrinum \ Grauer Andorn, Ungarischer Andorn / Branched Horehound (cultiv.). D Botan. Gar. Universit. Mainz 4.8. ... 2: Marrubium peregrinum \ Grauer Andorn, Ungarischer Andorn / Branched Horehound GR Zagoria, Monodendri 26.8.2007. ... 3: Marrubium peregrinum \ Grauer Andorn, Ungarischer Andorn / Branched Horehound GR Zagoria, Monodendri 26.8.2007. ... 4: Marrubium peregrinum \ Grauer Andorn, Ungarischer Andorn / Branched Horehound GR Zagoria, Monodendri 25.8.2007. ...
Marrubium
Marrubium peregrinum [L. ]
Marrubium vulgare | white horehound
Jablčník obyčajný (marrubium vulgare)
Consortium of Intermountain Herbaria - Marrubium vulgare
Duration: Perennial Nativity: Non-Native Lifeform: Subshrub General: Perennial exotic herb from a taproot; stems several, prostrate to ascending-erect, 20-100 cm long/tall, densely white wooly. Leaves: Opposite, blades 1-6 cm long, conspicuously wrinkled, ovate to round, with crenate margins; generally green and pubescent above, white wooly below. Flowers: Whorled in globular clusters in leaf axils, with spiny calyces; corolla 5-10 mm long, whitish. Fruits: 4 nutlets Ecology: On disturbed ground from 2,000-7,500 ft (610-2285 m); flowers April-October. Distribution: Introduced to N. Amer., except Alberta, Manitoba, ND, LA and FL ; south to S. Amer.; throughout the world on every continent. Notes: Distinguished by pungent-smelling, noticeably wrinkly, thick soft leaves and white-wooly pubescence on the whitish stems and undersides of leaves; and the inflorescences in verticils surrounding stems in dense clusters. This introduced perennial can form dense stands at mid-elevations in disturbed areas. ...
1 Marrubium Free Photos and Images | picjumbo
Photo: Marrubium vulgare 7. | Henriette's Herbal Homepage
Horehound Tincture, Marrubium vulgare leaf and flower extract, organic - Reverie Farm
Fresh Marrubium vulgare 1:2 in 75% organic cane alcohol, water. Grown using organic methods- never any GMO seeds or stock, ... Horehound Tincture, Marrubium vulgare leaf and flower extract, organic. Regular price $12.89 Sale ... Fresh Marrubium vulgare 1:2 in 75% organic cane alcohol, water.. Grown using organic methods- never any GMO seeds or stock, ...