Mesonephroma
Glutathione S-transferase expression in the human testis and testicular germ cell neoplasia. (1/47)
Glutathione S-transferase (GST) isoenzyme expression is altered in a variety of neoplasms and the enzymes are implicated in metabolism of carcinogens and resistance to drugs, including cisplatin. We have studied GST Alpha, Pi, Mu and microsomal isoenzyme expression by immunohistochemistry in normal and cryptorchid testes, intratubal germ cell neoplasia (ITGCN), seminoma and non-seminomatous germ cell tumours. In 16 stage II-IV malignant teratoma intermediate (MTI) both orchidectomy and post-treatment residual surgical masses were studied. All four isoenzymes were strongly expressed in Leydig and Sertoli cells. GST Pi was absent from normal spermatogonia but strongly expressed by the neoplastic germ cells of ITGCN and seminoma. GST Pi was strongly expressed in all elements of teratoma, irrespective of differentiation. There were no qualitative differences in expression between primary and post-chemotherapy metastases. GST Alpha expression in teratoma correlated with epithelial differentiation. GSTs may be important in normal spermatogenesis and protection of germ cells from teratogens and carcinogens. They may have a role in testicular tumour drug resistance but this role is not well defined. GST Pi is a new marker for ITGCN. (+info)Endodermal sinus tumor of vulva (a case report). (2/47)
An unusual case of endodermal sinus tumor (EST) of the ovary at an extragonadal site-vulva, in an unmarried female of 25 yr is reported. The patient presented only with a vulval swelling on the right side without any other signs or symptoms. The internal genital organs mainly the ovaries were normal. (+info)Intracranial and intraspinal dissemination from pineal yolk sac tumor treated by PVB therapy--case report. (3/47)
A 15-year-old male was admitted because of diplopia and persistent headache. Postcontrast computed tomography (CT) revealed a homogeneously enhanced large mass, 3 x 4 cm in size, in the pineal region and moderate obstructive hydrocephalus. A right ventriculoperitoneal shunt was installed. At that time, the serum alpha-fetoprotein (AFP) level increased to 23,036 ng/ml, but the level of serum beta-subunit of human chorionic gonadotropin was less than 0.2 ng/ml. These data indicated the tumor to be a pure yolk sac tumor. Following cisplatin-vinblastine-bleomycin (PVB) therapy and whole-brain irradiation (50 Gy), the tumor disappeared on CT, although the AFP level did not return to normal. Eight months after the completion of initial therapy, he had lumbago. Spinal magnetic resonance imaging revealed a metastatic mass at the L5-S2 levels, which was subtotally removed and histologically diagnosed as yolk sac tumor. Postoperative local irradiation (30 Gy) was performed. Seven months after the operation, spinal dissemination at the Th7 level occurred and, 1 month later, intracranial dissemination in the left cerebellopontine angle was detected. He died 25 months after the first admission. PVB therapy did not prevent spinal dissemination in this case. (+info)An endodermal sinus tumor in the cerebellopontine angle. (4/47)
Immunohistochemical and ultrastructural findings in a primary intracranial endodermal sinus tumor are reported in this paper. The tumor cells exhibited AFP, CEA and anti-alpha-1-trypsin positive immunoreactivity immunocytochemically. Aggregates of electron-dense material in the extra- and intracellular spaces and amorphous basement membrane-like substance were seen extracellularly by electron microscopy. The clinicopathological, immunocytochemical and ultrastructural features were consistent with the criteria for primary intracranial sinus tumor. (+info)SCID (severe combined immunodeficiency) mice as a new system to investigate metastasis of human tumors. (5/47)
In severe combined immunodeficiency (scid) mice which are deficient in T and B cell functions, human yolk sac tumor (YST-2) grew rapidly to enormous sizes in all of the animals after both subcutaneous and intraperitoneal transplantation, while only half of the subcutaneous and none of the intraperitoneal transplants were accepted in usual athymic nude mice. Furthermore, transplanted tumors metastasized spontaneously to distant organs such as lung, liver, kidney, pancreas, and spleen in scid mice, while metastases were not found in athymic nude mice. Similar results were observed in scid mice and scid-nude (streaker) double mutant mice with human classic (typical) seminoma which has been neither transplantable nor metastatic in athymic nude mice. Thus, scid mice provide an invaluable experimental system to investigate the mechanism of metastasis which is the most important and life-threatening problem in cancer patients. (+info)An immunohistochemical study of distribution of carcinoembryonic antigen in epithelial tumours of the ovary. (6/47)
An immunohistochemical study of the tissue CEA content of 82 epithelial neoplasms of the ovary has shown that mucinous tumours contain more of this substance than do their serous counterparts; otherwise a knowledge of tissue CEA content appears to be of little value in the differential histological diagnosis of this group of neoplasms. Among mucinous tumours there is only a partial correspondence between their degree of malignancy, as assessed histologically, and their content of CEA. It is postulated that immunohistological study of tissue CEA may add a degree of finesse to morphological analysis of these neoplasms and thus allow for a more precise grading of their degree of malignancy. (+info)Cytogenetic analysis of murine embryo-derived tumors. (7/47)
The possible relationship among malignancy, differentiation, and chromosomal constitution of primary embryo-derived tumors was studied. Tumors were induced by transplanting 7-day-old mouse embryos under the kidney capsule of syngeneic BALB/c recipients. Transplantation of 101 embryos resulted in 18 tumor-bearing mice: 36 teratocarcinomas; 18 teratomas; and 27 yolk sac tumors. Some of the yolk sac tumors proved to be retransplantable for several generations. Cytogenetic investigation of the primary embryo-derived tumors revealed that the majority of teratocarcinomas (82%) were chromosomally normal, whereas almost all (83%) karyotyped teratomas and yolk sac tumors had a highly abnormal chromosomal constitution. Most common aberrations were polyploidy; overrepresentation of chromosome 1, 6, 15, or 19; and an underrepresentation of chromosome 2, 4, 14, or a sex chromosome. (+info)Mesonephric adenocarcinoma (endometrioid type) of endocervix with diffuse mesonephric hyperplasia involving cervical wall and myometrium: an unusual case report. (8/47)
(+info)Mesonephroma is a very rare type of kidney tumor that originates from the mesonephric duct remnants, which are the embryonic precursors of the male reproductive system. This tumor typically affects older adults and is more common in men than women.
Mesonephromas are usually slow-growing and asymptomatic, making them difficult to detect at an early stage. When symptoms do occur, they may include flank pain, hematuria (blood in the urine), a palpable abdominal mass, and weight loss.
On imaging studies such as CT or MRI scans, mesonephromas typically appear as well-circumscribed masses within the kidney. The diagnosis is usually confirmed through a biopsy or surgical excision of the tumor.
Mesonephromas are composed of tubular structures lined with cuboidal to low columnar epithelial cells, often with clear cytoplasm. They may also contain areas of necrosis and hemorrhage. The treatment of mesonephroma typically involves surgical excision, and the prognosis is generally favorable, with a low risk of recurrence or metastasis. However, long-term follow-up is recommended due to the rarity and limited data on this type of tumor.
Walter Schiller
Clear-cell carcinoma
List of MeSH codes (C04)
International Classification of Diseases for Oncology
Index of oncology articles
Walter Schiller - Wikipedia
Code System Concept
tumor
Mesenchymal Chondrosarcoma of the Orbit
Cervical Cancer Library - Navigating Care
Kidney cancer | Drupal
DeCS
cell-biology
Proliferacija: Vzroki in razlogi - Symptoma Slovenija
pe��uch - nárečový slovník | Webslovník.sk
Neoplasms, Germ Cell and Embryonal | Profiles RNS
Mesonephroma | Profiles RNS
Search Strategy Used to Create the PubMed Cancer Filter
Biomarkers Search
Mesonephric and mesonephric-like carcinomas of the female genital tract: molecular characterization including cases with mixed...
Lexical Tools
Personal Electronic Dosimeter Market Increased demands | DiggersList
A C177537 GDC Value Terminology C171871 Crenigacestat An orally available inhibitor of the integral membrane protein gamma...
Growth Hormone in Adults With Growth Hormone Deficiency
MeSH Browser
MeSH Browser
DeCS
Lexical Tools
PMID- 5097483
t
Pesquisa | Portal Regional da BVS
Neoplasms, Germ Cell and Embryonal - MeSH - NCBI
Clear cell carc2
- Clear cell adenocarcinoma, also called clear cell carcinoma or mesonephroma, is a rare type of cervical adenocarcinoma. (navigatingcare.com)
- The most common type of kidney cancer is adenocarcinoma (90% of all kidney cancers), also called mesonephroma or clear cell carcinoma. (institutroialbertdeux.be)
Mesonephric1
- 15. [Various mesonephric tumors of the female genital tract with special reference to the significance of glomerulus-like units in Schiller's mesonephroma]. (nih.gov)
Descriptor1
- Mesonephroma" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (sdsu.edu)