A form of muscle hypertonia associated with upper MOTOR NEURON DISEASE. Resistance to passive stretch of a spastic muscle results in minimal initial resistance (a "free interval") followed by an incremental increase in muscle tone. Tone increases in proportion to the velocity of stretch. Spasticity is usually accompanied by HYPERREFLEXIA and variable degrees of MUSCLE WEAKNESS. (From Adams et al., Principles of Neurology, 6th ed, p54)

A new X linked neurodegenerative syndrome with mental retardation, blindness, convulsions, spasticity, mild hypomyelination, and early death maps to the pericentromeric region. (1/613)

We report on a family with an X linked neurodegenerative disorder consisting of mental retardation, blindness, convulsions, spasticity, and early death. Neuropathological examination showed mild hypomyelination. By linkage analysis, the underlying genetic defect could be assigned to the pericentromeric region of the X chromosome with a maximum lod score of 3.30 at theta=0.0 for the DXS1204 locus with DXS337 and PGK1P1 as flanking markers.  (+info)

A clinical guide to assess the role of lower limb extensor overactivity in hemiplegic gait disorders. (2/613)

BACKGROUND AND PURPOSE: The aim of this study was to assess the role of knee and ankle extensor overactivity in the hemiplegic gait observed in stroke victims and to propose a clinical guide for selecting patients before treatment of a supposed disabling spasticity. METHODS: A standardized physical examination procedure was performed in 135 consecutive stroke patients. All patients were able to walk without human assistance. The period after stroke ranged from 3 to 24 months (mean, 11.5+/-7.25 months). Spasticity was evaluated with the stroke victim in sitting position and during walking. Overactivity of the quadriceps was considered disabling when inducing inability to flex the knee during the swing phase despite adequate control of knee flexion in sitting and standing positions; overactivity of the triceps surae was considered to be disabling when heel strike was not possible despite good control of the ankle flexion in sitting position; triceps retraction was also considered. RESULTS: Disabling overactivity was observed in 56 (41.5%) patients: 11 times for the quadriceps femoris, 21 times for the triceps surae, and 21 times for both muscles. It was considered to be the main disorder impairing gait among only 16 (12%) patients: 9 for the quadriceps alone, 3 for the triceps alone, and 4 for both. Sitting spasticity of the lower limb was not predictive of disabling overactivity during walking. CONCLUSIONS: Extensor muscle overactivity is one of the components of gait disorders in stroke patients. The difficulty in assessing spasticity and its real causal effect in gait disturbances are discussed. A clinical guide is proposed.  (+info)

Impaired modulation of quadriceps tendon jerk reflex during spastic gait: differences between spinal and cerebral lesions. (3/613)

In healthy subjects, functionally appropriate modulation of short latency leg muscle reflexes occurs during gait. This modulation has been ascribed, in part, to changes in presynaptic inhibition of Ia afferents. The changes in modulation of quadriceps tendon jerk reflexes during gait of healthy subjects were compared with those of hemi- or paraparetic spastic patients. The spasticity was due to unilateral cerebral infarction or traumatic spinal cord injury, respectively. The modulation of the quadriceps femoris tendon jerk reflex at 16 phases of the step cycle was studied. The reflex responses obtained during treadmill walking were compared with control values obtained during gait-mimicking standing postures with corresponding levels of voluntary muscle contraction and knee angles. In healthy subjects the size of the reflexes was profoundly modulated and was generally depressed throughout the step cycle. In patients with spinal lesion the reflex depression during gait was almost removed and was associated with weak or no modulation during the step cycle. In patients with cerebral lesion there was less depression of the reflex size associated with a reduced reflex modulation on the affected side compared with healthy subjects. On the 'unaffected' side of these patients reflex modulation was similar to that of healthy subjects, but the reflex size during gait was not significantly different from standing control values. These observations suggest that the mechanisms responsible for the depression of reflex size and the modulation normally seen during gait in healthy subjects are impaired to different extents in spasticity of spinal or cerebral origin, possibly due to the unilateral preservation of fibre tracts in hemiparesis.  (+info)

Quantitative assessment of subclinical spasticity in human T-cell lymphotropic virus type I infection. (4/613)

OBJECTIVE: To compare human T-cell lymphotrophic virus type I (HTLV-I) seropositive and seronegative women for symptoms and signs of spasticity. BACKGROUND: Infection with HTLV-I causes tropical spastic paraparesis/ HTLV-I-associated myelopathy (TSP/HAM). Certain populations, including female commercial sex workers (FSW), are at increased risk of developing this infection. Fewer than 5% of HTLV-I-seropositive persons develop TSP/HAM, which is typically associated with spasticity. METHODS: Cross-sectional study of 255 registered FSW in Callao, Peru, involving a questionnaire detailing demographics and neurologic symptoms, standard neurologic examination, quantitative assessment of spasticity (QSA) of muscle tone, and serologic testing for HTLV-I. Participants and examiners were blinded to serology results. RESULTS: On the questionnaire and neurologic examination, none of the 32 HTLV-I-seropositive or 223 seronegative women had signs or symptoms of spasticity. However, mean values on QSA were significantly higher among seropositive women (27.1 Newton-meters/radian [N-m/r]) than among seronegative women (21.6 N-m/r, p = 0.01), indicating a subclinical increase in lower extremity tone. With values of QSA divided into tertiles, and the first tertile serving as the comparison group, the odds ratio for seropositivity was 1.4 (95% confidence interval [CI] 1.0 to 2.0) in the second and 3.1 (95% CI 2.2 to 4.3) in the third tertile, after adjusting for age and place of birth. CONCLUSIONS: Although a standard neurologic evaluation could not distinguish between women with and without HTLV-I infection, QSA indicated significantly increased lower extremity tone in those with infection. Long-term follow-up will determine whether these subclinical findings in asymptomatic women progress to overt TSP/HAM.  (+info)

A neurological disease caused by an expanded CAG trinucleotide repeat in the TATA-binding protein gene: a new polyglutamine disease? (5/613)

To investigate whether the expansion of CAG repeats of the TATA-binding protein (TBP) gene is involved in the pathogenesis of neurodegenerative diseases, we have screened 118 patients with various forms of neurological disease and identified a sporadic-onset patient with unique neurologic symptoms consisting of ataxia and intellectual deterioration associated with de novo expansion of the CAG repeat of the TBP gene. The mutant TBP with an expanded polyglutamine stretch (63 glutamines) was demonstrated to be expressed in lymphoblastoid cell lines at a level comparable with that of wild-type TBP. The CAG repeat of the TBP gene consists of impure CAG repeat and the de novo expansion involves partial duplication of the CAG repeat. The present study provides new insights into sporadic-onset trinucleotide repeat diseases that involve de novo CAG repeat expansion.  (+info)

"Task-oriented" exercise improves hamstring strength and spastic reflexes in chronic stroke patients. (6/613)

BACKGROUND AND PURPOSE: Despite the belief that after cerebral infarction only limited functional gains are possible beyond the subacute period, we tested the hypothesis that a 12-week program of "task-oriented" treadmill exercise would increase muscle strength and decrease spastic reflexes in chronic hemiparetic patients. METHODS: Fourteen subjects, aged 66+/-3 (mean+/-SEM) years, with residual gait deviations due to remote stroke (>6 months), underwent repeated measures of reflexive and volitional (concentric and eccentric) torque with use of isokinetic dynamometry on the hamstring musculature bilaterally. Torque output was measured at 4 angular velocities (30(o), 60(o), 90(o), and 120(o)/s). RESULTS: After 3 months of 3 times/wk low-intensity aerobic exercise, there were significant main effects (2 legs [P<0.01]x2 times [P<0. 01]x4 angular velocities [P<0.05]) for concentric torque production. Torque/time production in the concentric mode also improved significantly in the paretic (50%, P<0.01) and nonparetic hamstrings (31%, P<0.01). Eccentric torque/time production increased by 21% (P<0.01) and 22% (P<0.01) in the paretic and nonparetic hamstrings, respectively. Passive (reflexive) torque/time generation in the paretic hamstrings decreased by 11% (P<0.027). Reflexive torque/time was unchanged in the nonparetic hamstrings (P=0.45). CONCLUSIONS: These findings provide evidence that progressive treadmill aerobic exercise training improves volitional torque and torque/time generation and reduces reflexive torque/time production in the hemiparetic limb. Strength changes associated with improved functional mobility in chronic hemiparetic stroke survivors after treadmill training will be reported in future articles.  (+info)

Orthopedic management in autosomal recessive spastic ataxia of Charlevoix-Saguenay. (7/613)

OBJECTIVE: To review the orthopedic management of choice in patients having autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS). DESIGN: A retrospective study from April 1978 to April 1997. SETTING: Centre hospitalier de la Sagamie, Chicoutimi, Que. PATIENTS: A review of the records of patients having ARSACS who were identified in the registry of the Neuromuscular Diseases Clinic at the Centre hospitalier de la Sagamie revealed 26 patients who received surgical orthopedic treatment. Initially, the patients were offered conservative treatment, which consisted of physiotherapy sessions, the wearing of an ankle-foot orthosis or serial casting. When this was unsuccessful, foot surgery was considered. RESULTS: During the study period, 49 orthopedic procedures were done, including 24 triple arthrodeses; of these, 9 were combined with lengthening of the Achilles tendon. Most triple arthrodeses were done in patients between the ages of 30 and 49 years. The surgical options evolved during the study from Lambrinudi arthrodesis through arthrodesis of the ankle to triple arthrodesis with lengthening of the Achilles tendon. CONCLUSIONS: As a complement to conservative treatment, surgery has a place in the care of patients with ARSACS. Clinically, the most effective surgical procedures are triple arthrodesis with percutaneous lengthening of the Achilles tendon and adductor and psoas tenotomies combined with neurectomy of the obturator nerve for perineal hygiene.  (+info)

Periacetabular osteotomy in the treatment of neurogenic acetabular dysplasia. (8/613)

We carried out the Bernese periacetabular osteotomy for the treatment of 13 dysplastic hips in 11 skeletally mature patients with an underlying neurological diagnosis. Seven hips had flaccid paralysis and six were spastic. The mean age at the time of surgery was 23 years and the mean length of follow-up was 6.4 years. Preoperatively, 11 hips had pain and two had progressive subluxation. Before operation the mean Tonnis angle was 33 degrees, the mean centre-edge angle was -10 degrees, and the mean extrusion index was 53%. Postoperatively, they were 8 degrees, 25 degrees and 15%, respectively. Pain was eliminated in 7 patients and reduced in four in those who had preoperative pain. One patient developed pain secondary to anterior impingement from excessive retroversion of the acetabulum. Four required a varus proximal femoral osteotomy at the time of the pelvic procedure and one a late varus proximal femoral osteotomy for progressive subluxation. Before operation no patient had arthritis. At the most recent follow-up one had early arthritis of the hip (Tonnis grade I) and one had advanced arthritis (Tonnis grade III). Our results suggest that the Bernese periacetabular osteotomy can be used successfully to treat neurogenic acetabular dysplasia in skeletally mature patients.  (+info)

Muscle spasticity is a motor disorder characterized by an involuntary increase in muscle tone, leading to stiffness and difficulty in moving muscles. It is often seen in people with damage to the brain or spinal cord, such as those with cerebral palsy, multiple sclerosis, or spinal cord injuries.

In muscle spasticity, the muscles may contract excessively, causing rigid limbs, awkward movements, and abnormal postures. The severity of muscle spasticity can vary from mild stiffness to severe contractures that limit mobility and function.

Muscle spasticity is caused by an imbalance between excitatory and inhibitory signals in the central nervous system, leading to overactivity of the alpha motor neurons that control muscle contraction. This can result in hyperreflexia (overactive reflexes), clonus (rapid, rhythmic muscle contractions), and flexor or extensor spasms.

Effective management of muscle spasticity may involve a combination of physical therapy, medication, surgery, or other interventions to improve function, reduce pain, and prevent complications such as contractures and pressure sores.

  • Spasticity is common after spinal cord injury with about half of injured people who experience the increases in muscle tone and reflexes, as well as muscle spasms, find it problematic. (themiamiproject.org)
  • This study examined relationships between self-report of muscle spasms, physiological spasticity assessments, and involuntary muscle activity (muscle spasms) generated during a typical daily task - a transfer from wheelchair to bed - because people with spinal cord injury often describe their spasms when asked. (themiamiproject.org)
  • Dr. Thomas and her team found that strong, short duration muscle spasms during transfers were related to high self-reported spasm frequency, suggesting that injured individuals use the length of the contractions to count spasms. (themiamiproject.org)
  • Stronger spasms in all leg muscles, especially in quadriceps versus hamstrings muscles, and ankle flexors versus extensors, were correlated with greater overall spasm severity, which likely results in movement of the legs. (themiamiproject.org)
  • Even though the team's physiological measurements were not significantly related to the self-reported spasticity, their physiological measurements of both spinal inhibition and motoneuron excitability were related to the duration of the spasms. (themiamiproject.org)
  • This study is the first to provide evidence of a link between physiological assessments of spasticity and the duration and intensity of the muscle spasms that people experience. (themiamiproject.org)
  • Muscle relaxers, or muscle relaxants, are medications used to treat muscle spasms or muscle spasticity. (trochetadalafil.com)
  • Muscle spasms or cramps are sudden, involuntary contractions of a muscle or group of muscles. (trochetadalafil.com)
  • Prescription drugs can help relieve the pain and discomfort from muscle spasms or spasticity. (trochetadalafil.com)
  • In addition, certain over-the-counter medications may be used to treat aches and pains associated with muscle spasms. (trochetadalafil.com)
  • It is characterized by uncontrollable muscle spasms and body movements, tight or stiff muscles, and chronic pain. (pain-relief-centers.com)
  • In addition to the characteristic pain of spasms, spasticity may cause a feeling of tightness in the muscles, or it may be severe enough to result in painful spasms of the legs or arms. (trusted-medications.com)
  • Tizanidine works by temporarily relaxing the muscle and treating spasms by blocking the pain sensations that are sent to the brain. (trusted-medications.com)
  • It also increases the muscle tone associated with muscle spasms . (trusted-medications.com)
  • Alleviating muscle spasticity can help to decrease the intensity and pain of spasms, as well as increase the range of motions to allow improved functions. (cpravikumar.com)
  • Your muscles contract involuntarily, causing muscle spasms. (annsnews.com)
  • Spastic hypertonia involves uncontrollable muscle spasms, stiffening or straightening out of muscles, shock-like contractions of all or part of a group of muscles, and abnormal muscle tone. (wikipedia.org)
  • The main treatments for spasticity are physiotherapy and medicines that help reduce muscle spasms. (healthlinkbc.ca)
  • These medicines relax tight muscles and stop muscle spasms. (healthlinkbc.ca)
  • Further classified as antispasmodic agents, Robaxin and Flexeril are effective for treating acute, painful musculoskeletal conditions that cause discomfort and muscle spasms. (godsagendafornigeria.org)
  • Research is lacking on whether or not antispasmodics are more effective in treating muscle pain and spasms than NSAIDs or acetaminophen. (godsagendafornigeria.org)
  • Symptoms of spasticity may include increased muscle tone, rapid muscle contractions, exaggerated deep tendon reflexes, and/or muscle spasms. (biospace.com)
  • 2,3 The degree of spasticity can vary from mild muscle stiffness to severe, painful, and uncontrollable muscle spasms. (biospace.com)
  • Spasticity in children is a condition that causes muscle spasms and increased muscle stiffness in either the upper and/or lower limbs including the elbow, wrist, finger and calf muscles. (biospace.com)
  • Alternative to traditional medication, BOTOX® injections are FDA-approved to treat upper and lower limb spasticity and is often more successful than oral medication. (pain-relief-centers.com)
  • In July 2016, the US Food and Drug Administration (FDA) approved abobotulinumtoxinA (Dysport) for injection for the treatment of lower-limb spasticity in pediatric patients two years of age and older. (wikipedia.org)
  • [52] [53] AbobotulinumtoxinA is the first and only FDA-approved botulinum toxin for the treatment of pediatric lower limb spasticity. (wikipedia.org)
  • It primarily involves the antigravity muscles - flexors of the upper limb and extensors of the lower limb. (wikipedia.org)
  • Primary objective: To assess the inter-rater reliability of the Modified Modified Ashworth Scale (MMAS) in lower limb muscle spasticity. (elsevierpure.com)
  • Conclusions: The Modified Modified Ashworth Scale produced reliable measurements between raters in the assessment of lower limb muscle spasticity. (elsevierpure.com)
  • When Dysport was first FDA-approved in 2016 for pediatric lower limb spasticity, Ipsen was granted Orphan Drug exclusivity for pediatric patients whose lower limb spasticity was caused by cerebral palsy (CP). (biospace.com)
  • As a result, Dysport is now FDA-approved to treat both upper and lower limb spasticity in pediatric patients two years of age and older, including spasticity caused by cerebral palsy. (biospace.com)
  • The proactive step to resolve the uncertainty created by the previous CP carveout enables us as physicians to prescribe consistent therapy for pediatric patients experiencing both upper and lower limb spasticity," said Sarah Helen (Sally) Evans, MD, Division Chief of Rehabilitation Medicine in the Department of Pediatrics at the Children's Hospital of Philadelphia. (biospace.com)
  • This update ensures patient care, and treating the child as a whole person, can be the focus for physicians and their caregivers when making treatment decisions for both upper and lower limb spasticity. (biospace.com)
  • 1 Dysport is also the first FDA-approved botulinum toxin for the treatment of both upper and lower limb spasticity in children two years of age or older. (biospace.com)
  • Conditions that can cause muscle spasticity include multiple sclerosis (MS), cerebral palsy, and amyotrophic lateral sclerosis (ALS). (trochetadalafil.com)
  • Spasticity can vary greatly among people with brain injury, spinal cord injury, cerebral palsy , or multiple sclerosis. (trusted-medications.com)
  • Muscle spasticity may occur after any disease, defect or injury involving the brain or spinal cord, like stroke, multiple sclerosis or cerebral palsy , which make up the body's central nervous system. (cpravikumar.com)
  • Generally, spasticity happens when the cerebral cortex (a region of the brain that helps control movement) or the brainstem (which helps connect the brain to the spinal cord) are damaged after a stroke. (annsnews.com)
  • Spasticity can occur after other causes of brain damage too, including certain neurological conditions like multiple sclerosis and cerebral palsy. (annsnews.com)
  • An opportunity exists for two (2) high calibre higher degree research student to pursue a research career in paediatrics with a focus on exercise interventions to improve muscle health and function in children with cerebral palsy. (edu.au)
  • Individuals with cerebral palsy (CP) have muscles that are smaller, weaker and more resistant to stretch compared to typically developing people. (edu.au)
  • Hypotonia is different from muscle weakness, which is also common in some children with cerebral palsy. (healthychildren.org)
  • A: People who have severe spasticity resulting from conditions of the brain or spinal cord (such as multiple sclerosis, cerebral palsy, stroke, brain injury or spinal cord injury) may be candidates for ITB Therapy SM . (medtronic.com)
  • This effort illustrates our continued commitment to patients, helping to ensure children living with cerebral palsy can access the spasticity treatment that's most appropriate for them. (biospace.com)
  • Cerebral palsy is a developmental neurological disorder characterized by spasticity of some muscles, but also disuse in other muscles, and motor abnormalities. (cdc.gov)
  • Our data from a rat model of cerebral palsy shows that aberrant sensorimotor inputs during development resulting from prolonged disuse (i.e. hind limb immobilization during the first month of life) induces peripheral tissue changes, such as muscle atrophy and extracellular matrix changes, joint degeneration, and drastic topographical disorganization of primary somatosensory and motor cortical hind limb representations. (cdc.gov)
  • A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level of the cerebral cortex to the muscle fiber. (bvsalud.org)
  • MORAL-MUNOZ, J. A. Effects of a hippotherapy intervention on muscle spasticity in children with cerebral palsy: a randomized controlled trial. (bvsalud.org)
  • Muscle spasticity, on the other hand, is a continuous muscle spasm that causes stiffness, rigidity, or tightness that can interfere with normal walking, talking, or movement. (trochetadalafil.com)
  • Selective dorsal rhizotomy (SDR): Used to treat severe spasticity in the legs, this operation removes specific nerve roots to decrease muscle stiffness. (pain-relief-centers.com)
  • This may lead to repetitive contraction of the muscles, without intermittent relaxation, which over time causes stiffness , rigidity and spasticity. (cpravikumar.com)
  • They usually improve stiffness and reduce spasticity for a period of 3-5 months post procedure. (cpravikumar.com)
  • This can cause your muscles to contract or tense up, leading to stiffness and tightness. (biausa.org)
  • A sudden stop in therapy can result in serious baclofen withdrawal symptoms, such as high fever, changed mental status, muscle stiffness, and in rare cases, may result in the loss of function of many vital organs and death. (medtronic.com)
  • Spasticity is a condition in which there is an abnormal increase in muscle tone or stiffness in one or more muscles, which might interfere with movement. (biospace.com)
  • 1 When muscle stiffness in the calf is intensified, it prohibits the ankle from flexing as needed and causes the foot to be pointed down and in. (biospace.com)
  • Involuntary muscle stiffness. (hopkinsmedicine.org)
  • These are called centrally acting muscle relaxants and examples include baclofen, methocarbamol, and tizanidine. (trochetadalafil.com)
  • Intrathecal baclofen (ITB): Used to treat severe cases of spasticity, baclofen is delivered directly to the spinal cord by a pump and catheter system. (pain-relief-centers.com)
  • Surgery allows for a significant reduction in spasticity and pain with fewer side effects compared to taking baclofen orally. (trusted-medications.com)
  • Baclofen is the medicine most often prescribed for spasticity. (healthlinkbc.ca)
  • Learn more about your healthcare team for severe spasticity and ITB therapy with Lioresal ® Intrathecal (baclofen injection). (medtronic.com)
  • A: Lioresal ® Intrathecal (baclofen injection) is a muscle relaxant and antispastic medication that is used for treatment of severe spasticity caused by injury to or certain conditions of the brain or spinal cord. (medtronic.com)
  • A: Intrathecal Baclofen Therapy (ITB) is a treatment using Lioresal ® Intrathecal (baclofen) that is delivered into the fluid around your spinal cord (intrathecal) to help manage severe spasticity. (medtronic.com)
  • If your spasticity is due to spinal cord injury or multiple sclerosis and is not controlled with baclofen taken by mouth or you have side effects that are not acceptable from oral baclofen taken to treat your spasticity, you may be a candidate. (medtronic.com)
  • The intrathecal baclofen pump is a specialized neurosurgical treatment option for spasticity and/or dystonia. (hopkinsmedicine.org)
  • Baclofen is commonly used to treat spasticity. (hopkinsmedicine.org)
  • By relaxing the muscles, the baclofen reduces muscle tone and often improves mobility. (hopkinsmedicine.org)
  • For this short paper, the critical point to understand from applied kinesiology is that a high percentage of the time muscle spasm occurs when the muscle directly opposing the spastic muscle is WEAK. (davisvitalhealthcenter.com)
  • Botulinum toxin that can be injected into the spastic muscles. (medlineplus.gov)
  • It is used primarily in treating spasticity due to conditions like spinal cord injury and multiple sclerosis. (trusted-medications.com)
  • Muscle weakness, fatigue, and balance problems can lead to mobility issues when you have multiple sclerosis, but these tips can help improve your walking. (everydayhealth.com)
  • 3 Spasticity is usually caused by damage to nerve pathways in the brain or spinal cord that control muscle movement, and may occur in association with CP, spinal cord injury, multiple sclerosis, stroke, and brain or head trauma. (biospace.com)
  • Treatment options for spasticity after a stroke depend on the severity of your symptoms. (healthline.com)
  • There are also lifestyle changes people can make to reduce the symptoms of spasticity after a stroke. (healthline.com)
  • While spasticity can be painful, there are ways to reduce symptoms of the condition and improve your quality of life. (healthline.com)
  • Bradford B. Worrall, MD , a professor of neurology and public health at the University of Virginia , tells SELF that in his experience, many people deal with spasticity symptoms to varying degrees after a stroke. (annsnews.com)
  • Ahead, find out what we currently know about why spasticity happens after a stroke, the most common symptoms, and how the condition is treated. (annsnews.com)
  • If MRI shows that lesions are located in areas of the brain that are associated with the disorder, neurologists can then monitor for symptoms of spasticity, 2 Dr. Francisco says. (annsnews.com)
  • Some people with mild spasticity may have stiff muscles, while individuals with more severe cases can experience numerous symptoms. (annsnews.com)
  • Exercise, including muscle stretching, can help make symptoms less severe. (medlineplus.gov)
  • Positive symptoms include those that increase muscle activity through hyper-excitability of the stretch reflex (i.e., rigidity and spasticity) where negative symptoms include those of insufficient muscle activity (i.e. weakness) and reduced motor function. (wikipedia.org)
  • Different patterns of muscle weakness or hyperactivity can occur based on the location of the lesion, causing a multitude of neurological symptoms, including spasticity, rigidity, or dystonia. (wikipedia.org)
  • The risk of symptoms is probably greatest in children treated for spasticity, but symptoms can also occur in adults treated for spasticity and other conditions, particularly in those patients who have underlying conditions that would predispose them to these symptoms. (biospace.com)
  • [8] Early symptoms of ALS include stiff muscles , muscle twitches , gradual increasing weakness , and muscle wasting . (wikipedia.org)
  • Motor manifestations (such as spasticity, gait, and balance impairments), optic neuritis, and sensory symptoms appear early in the disease course ( 6 ), and usually lead to progressive limitation of daily life activities. (frontiersin.org)
  • Christine K. Thomas, Ph.D. , Professor, Department of Neurological Surgery and The Miami Project recently published a paper in Frontiers in Neuroscience titled Characterization of Involuntary Contractions after Spinal Cord Injury Reveals Associations between Physiological and Self-Reported Measures of Spasticity. (themiamiproject.org)
  • The condition causes many muscles to contract at once, leading to tightness and uncontrollable contractions, according to the Cleveland Clinic . (annsnews.com)
  • Series of repeated quick muscle contractions (clonus). (healthlinkbc.ca)
  • A common movement disorder characterized by abnormal muscle contractions. (hopkinsmedicine.org)
  • Botulinum toxin A (BTX-A) is widely used in the management of muscle spasticity in children. (nih.gov)
  • 2. In order to deal with muscle groups that are in spasm, a more focused approach with the help of a nerve block, like botulinum can be tried. (cpravikumar.com)
  • Botulinum toxin (such as Botox) injections given directly into the muscle can block messages that cause the muscle to spasm. (healthlinkbc.ca)
  • 1 Similarly, in 2019, Dysport received FDA approval for the treatment of upper limb spasticity in children two years of age and older, excluding upper limb spasticity caused by CP, due to Orphan Drug exclusivity granted to another manufacturer. (biospace.com)
  • Spasticity is generally caused by damage or disruption to the brain and spinal cord, which control muscle contraction and stretch reflexes. (trusted-medications.com)
  • Impaired ability of damaged motor neurons to regulate descending pathways gives rise to disordered spinal reflexes, increased excitability of muscle spindles, and decreased synaptic inhibition. (wikipedia.org)
  • On the contrary, spasticity is a velocity-dependent increase in tone resulting from the hyper excitability of stretch reflexes. (wikipedia.org)
  • The causes of spasticity in muscles may be as mild as the feeling of tightness of muscles or may be so severe as to produce pain. (trusted-medications.com)
  • Spasticity may also produce feelings of pain or tightness in and around joints and can cause low back pain. (trusted-medications.com)
  • Regularly exercising these areas can help ease tightness, prevent muscles from shortening, and maintain your full range of motion. (healthline.com)
  • It may also be called unusual tightness or increased muscle tone. (medlineplus.gov)
  • Spasticity is abnormal muscle tightness due to prolonged muscle contraction. (biausa.org)
  • This is the abnormal tightness in a child's muscles. (healthychildren.org)
  • The tightness is there even when the muscles are resting. (healthychildren.org)
  • cervical dystonia - a painful condition where the neck muscles involuntarily contract, causing your head to uncontrollably tilt forward or backward. (trochetadalafil.com)
  • How Painful is Spasticity in Muscles? (trusted-medications.com)
  • When untreated, prolonged spasticity can cause frozen joints and pressure sores on the skin, which can be very painful. (trusted-medications.com)
  • It can cause your muscles to get stiff, tight, and painful, causing you to be unable to move fluidly. (healthline.com)
  • Spasticity can be painful. (biausa.org)
  • In recent decades, a lot of progress has been made by several chiropractic physicians in the understanding of the non-local causes of muscle spasm. (davisvitalhealthcenter.com)
  • Two outstanding practitioners (who are researchers and teachers as well), Dr. George Goodheart and Dr. M. T. Morter, have especially contributed in understanding how to treat muscle spasm at a more fundamental level so the spasm is less likely to recur. (davisvitalhealthcenter.com)
  • Dr. George Goodheart is the founder of Applied Kinesiology (A.K.), a rational and complex discipline which is based on evaluation of muscle strength (weakness or over-stimulation/spasm) as a tool to understand the functioning of the many complex pathways in the body which when out of balance are involved with interference of innate healing and the normal healthy state. (davisvitalhealthcenter.com)
  • The weakness causes the opposing muscle to tighten and eventually spasm. (davisvitalhealthcenter.com)
  • It reduces the individual's capability to perform routine functions, and the muscle spasm itself may cause pain. (cpravikumar.com)
  • Your muscles may feel harder than usual during a spasm. (annsnews.com)
  • At times the muscles may jerk or spasm uncontrollably. (healthlinkbc.ca)
  • While static stretch has been the classical means to increase range of motion, PNF stretching has been used in many clinical settings to effectively reduce muscle spasticity. (wikipedia.org)
  • Dystonia is when muscles contract in an uncontrolled way. (healthychildren.org)
  • 1 Dysport has approved indications in the United States for the treatment of adults with cervical dystonia (CD) and for the treatment of spasticity in adult patients. (biospace.com)
  • Post-stroke spasticity can make it difficult to stretch, move, and accomplish everyday tasks. (healthline.com)
  • A physical therapist or occupational therapist can show you exercises that may help your post-stroke spasticity. (healthline.com)
  • Dr. Li's project focused on improving the quality of dual-energy X-ray absorptiometry to accurately measure muscle loss in post-stroke patients. (abpmr.org)
  • METHODS: Ninety cases of post-stroke muscle spasticity were randomized into a corresponding and central axis acupuncture group (group A), a conventional acupuncture group (group B) and a rehabilitation group (group C), 30 cases in each one. (qigonginstitute.org)
  • Severe, long-term spasticity may lead to contracture of muscles. (medlineplus.gov)
  • Rigidity is a severe state of hypertonia where muscle resistance occurs throughout the entire range of motion of the affected joint independent of velocity. (wikipedia.org)
  • Some people with severe spasticity may need surgery. (healthlinkbc.ca)
  • ITB therapy is FDA-approved for severe spasticity and covered by most insurance providers. (medtronic.com)
  • Use our online directory to find a doctor in your area specializing in severe spasticity. (medtronic.com)
  • Q: What is severe spasticity? (medtronic.com)
  • A: Severe spasticity is a condition that results from an injury to or disease of the brain or spinal cord. (medtronic.com)
  • With severe spasticity, you can experience stiffening of the muscles that makes your muscles feel like they are locked, or even jerk uncontrollably when you try to use them. (medtronic.com)
  • It has been difficult to quantify because only weak associations exist between clinical, physiological, and self-reported measures of spasticity. (themiamiproject.org)
  • We undertook this investigation to determine the interrater reliability of manual tests of elbow flexor muscle spasticity graded on a modified Ashworth scale. (indexindex.com)
  • Although the results were limited to the elbow flexor muscle group, we believe them to be positive enough to encourage further trials of the modified Ashworth scale for grading spasticity. (indexindex.com)
  • This prevents normal fluid motion of the muscles of the affected region of the body, which may hamper movement, speech and gait. (cpravikumar.com)
  • His brother had gait problems from age 20 years and, by age 21, lost the ability to run, showed dysarthria and muscle cramps. (bvsalud.org)
  • 2. Physical therapy is generally scheduled after Botox injection, in order to take advantage of the reduced spasticity. (cpravikumar.com)
  • Canada approved BOTOX® for axillary hyperhidrosis, focal muscle spasticity, and cosmetic treatment of wrinkles at the brow line. (medscape.com)
  • If that happens, you may experience spasticity, or an abnormal increase in muscle tone. (healthline.com)
  • According to a 2018 review published in the International Journal of Gerontology, 1 roughly 30 to 80% of people experience spasticity after a stroke, which is a pretty wide range. (annsnews.com)
  • To better understand why a stroke doesn't always cause spasticity, it helps to know how the nervous system works. (annsnews.com)
  • This list does not include all conditions that can cause spasticity. (medlineplus.gov)
  • But they may cause sleepiness, muscle weakness, and nausea. (healthlinkbc.ca)
  • The various spasticity treatment options available can be divided into physical therapy, medical and surgical treatments. (pain-relief-centers.com)
  • Treatments, such as injections and medications, can help reduce long-term damage from spasticity. (healthline.com)
  • Exercise and stretching are important treatments for spasticity. (healthlinkbc.ca)
  • Growing children can be adversely affected by spasticity as it affects their muscles and joints. (trusted-medications.com)
  • If you experience pain due to stiff joints and muscles, or if the condition interferes with your daily activities, see a doctor. (trusted-medications.com)
  • That can cause muscles and joints to get stiff and sore. (healthline.com)
  • Spasticity affects the muscles and joints of the extremities, and particularly impacts growing children. (biospace.com)
  • Experts from Orthopedics (who specialize in treating children's muscles, bones and joints) and Rehabilitation Medicine (who specialize in helping children get used to conditions that affect function) work together to evaluate your child's needs. (seattlechildrens.org)
  • We each independently graded the elbow flexor muscle spasticity of 30 patients with intracranial lesions. (indexindex.com)
  • Release the toe flexor muscles. (healthlinkbc.ca)
  • It is most commonly noted in the flexor muscles of the upper extremities, the proximal extensor muscles of the lower extremities, and the distal flexor muscles of the lower extremities. (medscape.com)
  • Often, these disruptions occur because the inhibitory and excitatory signals sent to the muscles are out of balance, causing them to lock in place. (trusted-medications.com)
  • Spasticity can occur when the nerve cells that carry messages from your brain to different parts of your body are damaged. (biausa.org)
  • You may be exposed to phenol if you undergo "chemical peels" to remove skin lesions with phenol-containing products or are treated for chronic pain or spasticity with injections of phenol. (cdc.gov)
  • Muscles weakened by toxin injection recover from paralysis after several months, so injection might seem to need to be repeated, but muscles adapt to the lengths at which they are chronically held, [48] so that if a paralyzed muscle is stretched by its antagonist, it grows longer, while the antagonist shortens, yielding a permanent effect. (wikipedia.org)
  • Hypertonia is a term sometimes used synonymously with spasticity and rigidity in the literature surrounding damage to the central nervous system, namely upper motor neuron lesions. (wikipedia.org)
  • During the passive stretch, a brief "free interval" is appreciated in spasticity but not in rigidity because the resting muscle is electromyographically silent in spasticity. (wikipedia.org)
  • In contrast, in rigidity, the resting muscle shows firing. (wikipedia.org)
  • What are Skeletal Muscle Relaxants? (trochetadalafil.com)
  • Skeletal muscle relaxants are drugs that are used to relax and reduce tension in muscles. (trochetadalafil.com)
  • Which Prescriptions are skeletal muscle relaxants? (trochetadalafil.com)
  • Skeletal muscle relaxants differ in the way they work (centrally or peripherally as discussed above), their side effects, and their effectiveness for certain conditions. (trochetadalafil.com)
  • Skeletal muscle relaxants consist of a varied range of medicines and some may not be suitable for people with certain medical conditions such as an enlarged prostate, epilepsy, glaucoma, intestinal problems, liver or kidney disease, or myasthenia gravis. (trochetadalafil.com)
  • Cyclobenzaprine is one of the most studied skeletal muscle relaxants, with solid evidence and systematic reviews supporting its effectiveness. (godsagendafornigeria.org)
  • This was a multicentre retrospective study of the safety profile and efficacy of BTX-A in children with chronic muscle spasticity. (nih.gov)
  • The treatment of chronic spasticity needs new approaches that address the limitations of current therapies, including low efficacy and cardiovascular and neurological side effects, that compound the patient burden. (motricbio.com)
  • 1. After consultation with a clinical neurologist and physical therapist, a patient's problem muscle group is identified, making sure that there are no irreversible contractures of the muscles. (cpravikumar.com)
  • OBJECTIVE: To observe the clinical effect of hemiplegic muscle spasticity treated with acupuncture on different acupoints in combination with rehabilitation. (qigonginstitute.org)
  • Although dantrolene acts directly on the muscle itself, it also appears to indirectly act on the central nervous system and can cause drowsiness. (trochetadalafil.com)
  • Note that several other medicines, notably diazepam, may also be used as a muscle relaxant and are not listed below. (trochetadalafil.com)
  • Medicines to treat spasticity. (medlineplus.gov)
  • To schedule a consultation with a healthcare practitioner in Sherman Oaks who specializes in muscle spasticity treatment , call (424) 365-1800 or contact Dr. Jeremy Fischer online . (pain-relief-centers.com)
  • Physical therapy is a non-surgical treatment that focuses on large muscle groups to improve range of motion and mobility. (trusted-medications.com)
  • The availability of a cannabinoid oromucosal spray (Sativex) for the management of treatment-resistant MS spasticity has provided a new opportunity for many patients. (nih.gov)
  • Our study aimed to assess the cost effectiveness of Sativex in Italian patients with treatment-resistant MS spasticity. (nih.gov)
  • No costs or spasticity/utility changes were assumed for no treatment intervention. (nih.gov)
  • Since spasticity can be either focal (affecting an arm or leg), regional (affecting a large area of the body like the torso) or generalized, the treatment plans are tailored for individual patients. (cpravikumar.com)
  • One of his fundamentally important contributions was the bringing of awareness that muscles are often weak due to factors that do not relate to the muscle itself or the nerve supplying the muscle. (davisvitalhealthcenter.com)
  • A diagnosis of muscle spasticity can usually be made after a physical examination to check nerve activity and shortening of muscles due to spasticity as well as checking for joint functions during active and passive movements. (cpravikumar.com)
  • The nerve blocking agent will stop transmission of impulses through the nerve to the affected muscles, thereby reducing the spasticity of the muscle. (cpravikumar.com)
  • Sometimes surgery to release the tendon or to cut the nerve-muscle pathway. (medlineplus.gov)
  • In the 1950s, Dr. Vernon Brooks discovered that when BoNT-A is injected into a hyperactive muscle, it blocks the release of acetylcholine from motor nerve endings. (medscape.com)
  • Muscle spasticity is caused by injury to parts of the brain or spinal cord involved with movement. (trochetadalafil.com)
  • Spasticity usually occurs because of damage to the part of the brain or spinal cord that controls voluntary movement. (healthlinkbc.ca)

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