Nairobi Sheep Disease
Nairobi sheep disease virus
Nairovirus
Sheep
Kenya
Nairobi sheep disease virus, an important tick-borne pathogen of sheep and goats in Africa, is also present in Asia. (1/6)
Nairobi sheep disease (NSD) virus is the prototype of the tick-borne NSD serogroup, genus Nairovirus, family Bunyaviridae. It is highly pathogenic for sheep and goats, causes disease in humans, and is widespread throughout East Africa. Ganjam virus has caused disease in goats and humans in India. Due to their occurrence on different continents and association with different ticks, these viruses were considered distinct despite serologic cross-reactivity. Their S RNA genome segments and encoded nucleocapsid proteins were found to be 1590 nucleotides and 482 amino acids in length and differed by only 10 and 3% at nucleotide and amino acid levels, respectively. Genetic and serologic data demonstrate that Ganjam virus is an Asian variant of NSD virus. These viruses were phylogenetically more closely related to Hazara virus than Dugbe virus. (+info)The high genetic variation of viruses of the genus Nairovirus reflects the diversity of their predominant tick hosts. (2/6)
The genus Nairovirus (family Bunyaviridae) contains seven serogroups consisting of 34 predominantly tick-borne viruses, including several associated with severe human and livestock diseases [e.g., Crimean Congo hemorrhagic fever (CCHF) and Nairobi sheep disease (NSD), respectively]. Before this report, no comparative genetic studies or molecular detection assays had been developed for this virus genus. To characterize at least one representative from each of the seven serogroups, reverse transcriptase-polymerase chain reaction (RT-PCR) primers targeting the L polymerase-encoding region of the RNA genome of these viruses were successfully designed based on conserved amino acid motifs present in the predicted catalytic core region. Sequence analysis showed the nairoviruses to be a highly diverse group, exhibiting up to 39.4% and 46.0% nucleotide and amino acid identity differences, respectively. Virus genetic relationships correlated well with serologic groupings and with tick host associations. Hosts of these viruses include both the hard (family Ixodidae) and soft (family Argasidae) ticks. Virus phylogenetic analysis reveals two major monophyletic groups: hard tick and soft tick-vectored viruses. In addition, viruses vectored by Ornithodoros, Carios, and Argas genera ticks also form three separate monophyletic lineages. The striking similarities between tick and nairovirus phylogenies are consistent with possible coevolution of the viruses and their tick hosts. Fossil and phylogenetic data placing the hard tick-soft tick divergence between 120 and 92 million years ago suggest an ancient origin for viruses of the genus Nairovirus. (+info)Ganjam virus/Nairobi sheep disease virus induces a pro-inflammatory response in infected sheep. (3/6)
(+info)A survey of Nairobi sheep disease antibody in sheep and goats, wild ruminants and rodents within Kenya. (4/6)
The distribution of antibody to Nairobi sheep disease in sheep and goats in Kenya was found to coincide closely with that of the tick, Rhipicephalus appendiculatus. The proportions of a population in an enzootic area with antibody was similar in the different age groups. No antibody to the virus was found in rodent sera and while some low titres were found in some wild ruminant sera, these were considered to be most likely cross reactions with antibody to related viruses. (+info)Nairobi sheep disease in Kenya. The isolation of virus from sheep and goats, ticks and possible maintenance hosts. (5/6)
Nairobi sheep disease was seen principally upon movement of susceptible animals into the enzootic areas. This occurred most frequently for marketing purposes near the main centres of population. Other outbreaks followed local breakdowns in tick control measures. The disease did not occur in epizootic form during the period under consideration. Nairobi sheep disease was isolated from pools of Rhipicephalus appendiculatus but not from many pools of other tick species. No virus was isolated from the blood or tissues of a range of wild ruminants and rodents. (+info)Investigation of tick-borne viruses as pathogens of humans in South Africa and evidence of Dugbe virus infection in a patient with prolonged thrombocytopenia. (6/6)
In the course of investigating suspected cases of viral haemorrhagic fever in South Africa patients were encountered who had been bitten by ticks, but who lacked evidence of infection with Crimean-Congo haemorrhagic fever (CCHF) virus or non-viral tick-borne agents. Cattle sera were tested by enzyme-linked immunoassay to determine whether tick-borne viruses other than CCHF occur in the country. The prevalence of antibody in cattle sera was 905/2116 (42.8%) for CCHF virus, 70/1358 (5.2%) for Dugbe, 21/1358 (1.5%) for louping ill, 6/450 (1.3%) for West Nile, 7/1358 (0.5%) for Nairobi sheep disease, 3/625 (0.5%) for Kadam and 2/450 (0.4%) for Chenuda. No reactions were recorded with Hazara, Bahig, Bhanja, Thogoto and Dhori viruses. The CCHF findings confirmed previous observations that the virus is widely prevalent within the distribution range of ticks of the genus Hyalomma, while antibody activity to Dugbe antigen was detected only within the distribution range of the tick Amblyomma hebraeum. Cross-reactivity for the nairoviruses, Hazara, Nairobi sheep disease and Dugbe, was detected in serum samples from 3/72 human patients with confirmed CCHF infection, and serum from 1/162 other patients reacted monospecifically with Dugbe antigen. The latter patient suffered from febrile illness with prolonged thrombocytopenia. (+info)I'm sorry for the confusion, but "Nairobi Sheep Disease" is not a recognized medical term or condition. It is actually a veterinary disease that affects sheep and goats, primarily in Africa. The disease is caused by a virus and is characterized by high fever, severe diarrhea, and sudden death. I hope this clarifies any confusion! If you have any questions related to human health, please don't hesitate to ask.
Nairobi Sheep Disease Virus (NSDV) is an enveloped, double-stranded RNA virus belonging to the family Bunyaviridae and genus Nairovirus. This virus is the causative agent of Nairobi sheep disease (NSD) and related diseases in small ruminants, particularly sheep and goats. The disease is characterized by high fever, severe hemorrhagic gastroenteritis, and rapid death, resulting in significant economic losses in endemic areas.
The NSDV genome consists of three segments: large (L), medium (M), and small (S). The L segment encodes the RNA-dependent RNA polymerase, the M segment encodes two glycoproteins (Gn and Gc) and a nonstructural protein (Nsm), while the S segment encodes the nucleocapsid protein (N) and a nonstructural protein (NSs).
The virus is primarily transmitted through ticks, mainly of the genus Rhipicephalus. The main vector for NSDV is Rhipicephalus appendiculatus, although other species such as Rhipicephalus zambeziensis and Amblyomma variegatum can also transmit the virus.
Nairobi sheep disease is prevalent in East Africa, particularly in Kenya, Tanzania, Uganda, and southern Sudan. Vaccination of susceptible animals and tick control measures are essential for preventing and controlling NSDV infections in endemic areas.
Nairovirus is a genus of viruses in the family Bunyaviridae. They are negative-sense, single-stranded RNA viruses and are transmitted to humans and animals through tick bites. The name "Nairovirus" comes from the initials of the National Institute for Virology in South Africa, where the first virus in this genus was discovered.
Nairoviruses can cause severe febrile illnesses in humans, including hemorrhagic fever and neurological symptoms. Some of the more well-known nairoviruses include Crimean-Congo hemorrhagic fever virus (CCHFV), which is found in Africa, Asia, Eastern Europe, and the Middle East, and Nairobi sheep disease virus (NSDV), which primarily infects sheep and goats but can also cause illness in humans.
It's important to note that nairoviruses are zoonotic, meaning they can be transmitted from animals to humans, and can pose a significant public health risk in areas where they are endemic. Prevention measures include avoiding tick bites, using personal protective equipment when handling infected animals, and implementing appropriate infection control practices in healthcare settings.
I apologize, but "sheep" is not a term that has a medical definition. It is a common animal with the scientific name Ovis aries. If you have any medical or health-related questions, I would be happy to try and help answer those for you.
I'm sorry for any confusion, but "Kenya" is not a medical term. It is the name of a country located in East Africa, known for its diverse wildlife and geography, including savannas, lakelands, the dramatic Great Rift Valley, and mountain highlands. It is also where you can find the Maasai Mara Reserve, known for its annual wildebeest migrations, and vast Nairobi National Park. The capital city of Kenya is Nairobi. If you have any questions about medical terms or concepts, I would be happy to help with those!
I'm happy to help, but I want to clarify that the term "sheep diseases" refers to a wide range of health issues that can affect sheep populations. It's not a single medical condition with a specific definition. Here are some examples of common diseases that can affect sheep:
1. Ovine Johne's Disease (OJD): A chronic, infectious disease caused by the bacterium Mycobacterium avium subspecies paratuberculosis. It affects the intestines and can cause weight loss, diarrhea, and death.
2. Footrot: A highly contagious bacterial infection that affects the feet of sheep, causing lameness, swelling, and pain. It's caused by the bacteria Dichelobacter nodosus.
3. Caseous Lymphadenitis (CL): A chronic infectious disease caused by the bacterium Corynebacterium pseudotuberculosis. It affects the lymph nodes and can cause abscesses, weight loss, and death.
4. Contagious Ecthyma (Orf): A highly contagious viral infection that affects the skin and mucous membranes of sheep, causing sores and lesions.
5. Mastitis: An inflammation of the mammary gland in sheep, usually caused by a bacterial infection. It can cause decreased milk production, fever, and loss of appetite.
6. Pneumonia: A respiratory infection that can affect sheep, causing coughing, difficulty breathing, and fever. It can be caused by various bacteria or viruses.
7. Enterotoxemia: A potentially fatal disease caused by the overproduction of toxins in the intestines of sheep, usually due to a bacterial infection with Clostridium perfringens.
8. Polioencephalomalacia (PEM): A neurological disorder that affects the brain of sheep, causing symptoms such as blindness, circling, and seizures. It's often caused by a thiamine deficiency or excessive sulfur intake.
9. Toxoplasmosis: A parasitic infection that can affect sheep, causing abortion, stillbirth, and neurological symptoms.
10. Blue tongue: A viral disease that affects sheep, causing fever, respiratory distress, and mouth ulcers. It's transmitted by insect vectors and is often associated with climate change.