Neisseriaceae
Eikenella
Neisseria
RNA, Ribosomal, 16S
DNA, Ribosomal
Molecular Sequence Data
Comparative activity of quinupristin/dalfopristin and RPR 106972 and the effect of medium on in-vitro test results. (1/118)
Quinupristin/dalfopristin and RPR 106972 were active in vitro against a wide range of aerobic Gram-positive organisms including Enterococcus faecium. However, most isolates of Enterococcus faecalis were resistant or of intermediate sensitivity. Against Staphylococcus aureus quinupristin/dalfopristin was more active but for all other species the range of activity of the two drugs was the same or RPR 106972 was more active. RPR 106972 was also more active against the respiratory pathogens Haemophilus influenzae and Moraxella catarrhalis. Quinupristin/dalfopristin MICs for isolates of H. influenzae (1-8 mg/L) clustered around the breakpoint. There were differences in the quality of growth, but little difference in MICs or zone diameters was obtained on three different media: Mueller-Hinton (MHA), Iso-Sensitest (ISA), and Diagnostic Sensitivity Test (DST) agars. The addition of blood to the medium increased MICs 2- to 4-fold, with MHA showing the greatest increase, and reduced zone diameters around quinupristin/dalfopristin discs by 3-4 mm, with the greatest effect on ISA. (+info)Pathogenic neisseriae: complexity of pathogen-host cell interplay. (2/118)
Recent studies have provided insight into the function of important neisserial adhesins (pili and Opa) and their interaction with cellular receptors, including members of heparan sulfate proteoglycan, CD66, and integrin receptor families. These interactions not only allow colonization of the human mucosa but also stimulate cellular signaling cascades involving phosphatidylcholine-dependent phospholipase C, acidic sphingomyelinase and protein kinase C in epithelial cells, and Src-related kinases, Rac1, p21-activated kinase, and Jun N-terminal kinase in phagocytic cells. Activation of these pathways is essential for cellular entry and intracellular accommodation of the pathogens but also leads to early induction of cytokine release, thus priming the immune response. Detailed knowledge of the cellular signaling cascades that are activated by infection will aid us in applying both current and novel interfering drugs (in addition to classical antibiotic therapy) as therapy and prophylaxis for persistent or otherwise difficult-to-treat bacterial infections, including periodontal infections. (+info)Analysis of the immunological responses to transferrin and lactoferrin receptor proteins from Moraxella catarrhalis. (3/118)
Moraxella catarrhalis expresses surface receptor proteins that specifically bind host transferrin (Tf) and lactoferrin (Lf) in the first step of the iron acquisition pathway. Acute- and convalescent-phase antisera from a series of patients with M. catarrhalis pulmonary infections were tested against Tf and Lf receptor proteins purified from the corresponding isolates. After the purified proteins had been separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blotting, we observed strong reactivity against Tf-binding protein B (TbpB; also called OMP1) and Lf-binding protein B (LbpB) but little or no reactivity against Tf-binding protein A (TbpA) or Lf-binding protein A (LbpA), using the convalescent-phase antisera. Considerable antigenic heterogeneity was observed when TbpBs and LbpBs isolated from different strains were tested with the convalescent-phase antisera. Comparison to the reactivity against electroblotted total cellular proteins revealed that the immune response against LbpB and TbpB constitutes a significant portion of the total detectable immune response to M. catarrhalis proteins. Preparations of affinity-isolated TbpA and LbpA reacted with convalescent-phase antisera in a solid-phase binding assay, but blocking with soluble TbpB, soluble LbpB, or extracts from an LbpA(-) mutant demonstrated that this reactivity was attributed to contaminants in the TbpA and LbpA preparations. These studies demonstrate the immunogenicity of M. catarrhalis TbpB and LbpB in humans and support their potential as vaccine candidates. (+info)Effect of carbon dioxide on testing of susceptibilities of respiratory tract pathogens to macrolide and azalide antimicrobial agents. (4/118)
The in vitro activities of erythromycin, azithromycin, and clarithromycin against 178 clinical isolates from the lower respiratory tract of patients with chronic obstructive pulmonary disease were determined by an agar dilution method. The plates were incubated in air alone or in 5% carbon dioxide. The MICs measured in air alone were lower for most isolates than those measured in 5% carbon dioxide, illustrating the "pH effect" of incubation in carbon dioxide. Testing of isolates in 5% carbon dioxide on pH-adjusted medium (pH 8.4) resulted in MICs of one or two doubling dilutions lower than those obtained on agar with a neutral pH. A bioassay of the three agents incubated in air and in 5% carbon dioxide resulted in a significant loss of activity of all three agents in the carbon dioxide-enriched atmosphere. However, this loss-of-activity effect was significantly reduced when the bioassay medium was adjusted to pH 8.4 prior to incubation in 5% carbon dioxide. (+info)Analysis of antigenic structure and human immune response to outer membrane protein CD of Moraxella catarrhalis. (5/118)
Moraxella catarrhalis is an important cause of otitis media in children and lower respiratory tract infections in adults with chronic obstructive pulmonary disease (COPD). Outer membrane protein CD (OMP CD) is a 45-kDa protein which is a potential vaccine antigen to prevent infections caused by M. catarrhalis. Eight monoclonal antibodies were used to study the antigenic structure of the OMP CD molecule by assaying recombinant peptides corresponding to the sequence of the protein. This approach identified two surface-exposed epitopes, including one near the amino terminus (amino acids 25 to 44) and one in the central region of the molecule (amino acids 261 to 331). Assays with serum and sputum supernatants of adults with COPD revealed variable levels of antibodies to OMP CD among individuals. To determine which portions of the OMP CD molecule were recognized by human antibodies, three human serum samples were studied with six recombinant peptides which span the sequence of OMP CD. All three sera contained immunoglobulin G antibodies which recognized exclusively the peptide corresponding to amino acids 203 to 260 by immunoblot assay. Adsorption experiments with whole bacteria established that some of the human antibodies are directed at surface-exposed epitopes on OMP CD. We conclude that OMP CD is a highly conserved molecule which contains at least two separate epitopes which are exposed on the bacterial surface. While individual adults with COPD show variability in the immune response to OMP CD, a specific region of the OMP CD molecule (amino acids 203 to 260) is important as a target of the human immune response. (+info)DNA restriction patterns produced by pulsed-field gel electrophoresis in Moraxella catarrhalis isolated from different geographical areas. (6/118)
Pulsed field gel electrophoresis (PFGE) of the genomic DNA of Moraxella catarrhalis was done in 172 strains isolated from sputum of patients with respiratory infections in Nagasaki (130 strains), Europe (14 strains), Thailand (6 strains), Uganda (3 strains), Bangladesh (5 strains) and Kuwait (14 strains). Restriction endonuclease with SmaI generated 4-16 DNA fragments ranging from 1000 kb to 24.25 kb and was classified into 31 major groups. It was found that there were wide variations of DNA restriction patterns of strains isolated from the same and different geographical areas. DNA restriction patterns of strains isolated in Nagasaki during the last 12 years showed dynamic changes of the predominant strains in each time period. We conclude from this study that PFGE is a suitable method to document interstrain variation in M. catarrhalis. (+info)Survey of susceptibilities of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis isolates to 26 antimicrobial agents: a prospective U.S. study. (7/118)
An antimicrobial susceptibility surveillance study of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis isolates was performed during the winter of 1996-1997 in order to determine their susceptibilities to 5 fluoroquinolones and 21 other antimicrobial agents. Broth microdilution MICs were determined for 2, 752 isolates from 51 U.S. medical centers. Of the 1,276 S. pneumoniae isolates, 64% were susceptible, 17% were intermediate, and 19% were highly resistant to penicillin. On the basis of the MICs at which 90% of isolates are inhibited and modal MICs, the hierarchy of the five fluoroquinolones from most to least active was grepafloxacin > sparfloxacin > levofloxacin = ciprofloxacin > ofloxacin. For S. pneumoniae isolates for which penicillin MICs were elevated, the MICs of the cephalosporins, macrolides, clindamycin, tetracycline, and trimethoprim-sulfamethoxazole were also elevated, but the MICs of the fluoroquinolones, vancomycin, and rifampin were not. The prevalence of penicillin-susceptible pneumococci varied by U.S. Bureau of the Census region (range, 44% in the East South Central region to 75% in the Pacific region). In addition, S. pneumoniae isolates from blood were significantly more susceptible to penicillin than those from respiratory, ear, or eye specimens, and pneumococci from patients +info)Resistance surveillance of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis isolated in the United States, 1997-1998. (8/118)
A national antimicrobial resistance surveillance study was conducted from December 1997 to May 1998 to determine the prevalence of antimicrobial resistance in 6620 clinical isolates of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis. In this centralized study, which involved 163 institutions located in 43 states, we determined MICs for representatives of five antimicrobial classes: beta-lactams (penicillin, co-amoxiclav, cefuroxime, ceftriaxone), macrolides (azithromycin, clarithromycin), co-trimoxazole, glycopeptides (vancomycin) and fluoroquinolones (levofloxacin). In most S. pneumoniae isolates, all antimicrobials were to be found active, but amongst penicillin-resistant isolates (MICs > or = 2 mg/L), resistance to other beta-lactams, macrolides and co-trimoxazole was common. For vancomycin and levofloxacin, however, activity was not associated with penicillin resistance. The prevalence of penicillin-nonsusceptible (intermediate and resistant) pneumococci was highest in the South Atlantic (44%) and East South Central (43%) regions and lowest in the Mid-Atlantic (28%) and New England (28%) regions. Resistance to beta-lactams, macrolides and co-trimoxazole was more commonly found amongst respiratory isolates than blood isolates and in strains from patients < or = 12 years old than from older patients. beta-lactamase, which was detected in 33% of H. influenzae and 92% of M. catarrhalis strains, did not affect the activity of the beta-lactams under study other than ampicillin. Certain agents, such as vancomycin and the fluoroquinolones, remain highly active, and well-designed surveillance systems that monitor MIC distributions would be needed to detect a potential for reduced susceptibility. In addition, surveillance programmes should be designed to collect information about associated resistance as well as differences in prevalence associated with region, specimen source and patient age. (+info)Neisseriaceae is a family of gram-negative, aerobic bacteria that includes several genera of medically significant organisms. The most well-known members of this family are Neisseria and Kingella, which include species that can cause various infections in humans.
The Neisseria genus includes several important human pathogens, such as N. gonorrhoeae (the causative agent of gonorrhea) and N. meningitidis (a leading cause of bacterial meningitis and sepsis). These organisms are typically found in the mucosal membranes of the respiratory and urogenital tracts.
The Kingella genus includes several species that can cause invasive infections, such as K. kingae (a common cause of bone and joint infections in young children) and K. denitrificans (which has been associated with endocarditis and bacteremia).
Overall, Neisseriaceae is an important family of bacteria that includes several significant human pathogens, many of which can cause serious and potentially life-threatening infections if left untreated.
Neisseriaceae infections refer to illnesses caused by bacteria belonging to the family Neisseriaceae, which includes several genera of gram-negative diplococci. The most common pathogens in this family are Neisseria gonorrhoeae and Neisseria meningitidis.
* N. gonorrhoeae is the causative agent of gonorrhea, a sexually transmitted infection that can affect the genital tract, rectum, and throat. It can also cause conjunctivitis in newborns who contract the bacteria during childbirth.
* N. meningitidis is responsible for meningococcal disease, which can present as meningitis (inflammation of the membranes surrounding the brain and spinal cord) or septicemia (bloodstream infection). Meningococcal disease can be severe and potentially life-threatening, with symptoms including high fever, headache, stiff neck, and a rash.
Other Neisseriaceae species that can cause human infections, though less commonly, include Moraxella catarrhalis (a cause of respiratory tract infections, particularly in children), Kingella kingae (associated with bone and joint infections in young children), and various other Neisseria species (which can cause skin and soft tissue infections, endocarditis, and other invasive diseases).
'Eikenella' is a genus of Gram-negative, facultatively anaerobic, rod-shaped bacteria that are part of the normal human microbiota, particularly in the oral cavity and upper respiratory tract. The most common species is *Eikenella corrodens*. These bacteria can cause localized or systemic infections, often following trauma or dental procedures, and are sometimes associated with human bites or wounds contaminated with saliva. Infections caused by Eikenella spp. can be difficult to diagnose due to their slow growth and fastidious nature, but they usually respond well to antibiotic therapy.
"Neisseria" is a genus of gram-negative, aerobic bacteria that are commonly found as part of the normal flora in the human body, particularly in the mouth, nose, and genital tract. Some species of Neisseria can cause diseases in humans, the most well-known being Neisseria meningitidis (meningococcus), which can cause meningitis and sepsis, and Neisseria gonorrhoeae (gonococcus), which causes the sexually transmitted infection gonorrhea. These bacteria are named after German physician and bacteriologist Albert Neisser, who first described them in the late 19th century.
Ribosomal RNA (rRNA) is a type of RNA that combines with proteins to form ribosomes, which are complex structures inside cells where protein synthesis occurs. The "16S" refers to the sedimentation coefficient of the rRNA molecule, which is a measure of its size and shape. In particular, 16S rRNA is a component of the smaller subunit of the prokaryotic ribosome (found in bacteria and archaea), and is often used as a molecular marker for identifying and classifying these organisms due to its relative stability and conservation among species. The sequence of 16S rRNA can be compared across different species to determine their evolutionary relationships and taxonomic positions.
Ribosomal DNA (rDNA) refers to the specific regions of DNA in a cell that contain the genes for ribosomal RNA (rRNA). Ribosomes are complex structures composed of proteins and rRNA, which play a crucial role in protein synthesis by translating messenger RNA (mRNA) into proteins.
In humans, there are four types of rRNA molecules: 18S, 5.8S, 28S, and 5S. These rRNAs are encoded by multiple copies of rDNA genes that are organized in clusters on specific chromosomes. In humans, the majority of rDNA genes are located on the short arms of acrocentric chromosomes 13, 14, 15, 21, and 22.
Each cluster of rDNA genes contains both transcribed and non-transcribed spacer regions. The transcribed regions contain the genes for the four types of rRNA, while the non-transcribed spacers contain regulatory elements that control the transcription of the rRNA genes.
The number of rDNA copies varies between species and even within individuals of the same species. The copy number can also change during development and in response to environmental factors. Variations in rDNA copy number have been associated with various diseases, including cancer and neurological disorders.
Bacterial DNA refers to the genetic material found in bacteria. It is composed of a double-stranded helix containing four nucleotide bases - adenine (A), thymine (T), guanine (G), and cytosine (C) - that are linked together by phosphodiester bonds. The sequence of these bases in the DNA molecule carries the genetic information necessary for the growth, development, and reproduction of bacteria.
Bacterial DNA is circular in most bacterial species, although some have linear chromosomes. In addition to the main chromosome, many bacteria also contain small circular pieces of DNA called plasmids that can carry additional genes and provide resistance to antibiotics or other environmental stressors.
Unlike eukaryotic cells, which have their DNA enclosed within a nucleus, bacterial DNA is present in the cytoplasm of the cell, where it is in direct contact with the cell's metabolic machinery. This allows for rapid gene expression and regulation in response to changing environmental conditions.
Molecular sequence data refers to the specific arrangement of molecules, most commonly nucleotides in DNA or RNA, or amino acids in proteins, that make up a biological macromolecule. This data is generated through laboratory techniques such as sequencing, and provides information about the exact order of the constituent molecules. This data is crucial in various fields of biology, including genetics, evolution, and molecular biology, allowing for comparisons between different organisms, identification of genetic variations, and studies of gene function and regulation.
Competence factor
List of MeSH codes (C01)
Diplococcus
Two-spotted bumble bee
Elizabeth O. King
Snodgrassella alvi
Natural competence
Pilus
Neisseria
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Bacterial9
- Most bacterial pathogens responsible for such infections are enclosed by polysaccharide capsules that protect them from phagocytosis and complement-mediated killing, ensuring their persistence on the respiratory mucosae and survival in the bloodstream and deep body tissues ( 3 ). (cdc.gov)
- Azithromycin is a prescription medication used to treat many bacterial infections such as those of the lungs and airways, eyes, ears, sinuses, skin, throat, and infections from sexually transmitted diseases. (rxwiki.com)
- Gram-Negative Bacterial Infections" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
- This graph shows the total number of publications written about "Gram-Negative Bacterial Infections" by people in this website by year, and whether "Gram-Negative Bacterial Infections" was a major or minor topic of these publications. (rush.edu)
- Below are the most recent publications written about "Gram-Negative Bacterial Infections" by people in Profiles. (rush.edu)
- Acquired dysfunctional immunity in cirrhosis predisposes patients to frequent bacterial infections, especially spontaneous bacterial peritonitis (SBP), leading to systemic inflammation that is associated with poor outcome. (frontiersin.org)
- Acquired dysfunctional immunity in cirrhosis predisposes patients to frequent bacterial infections contributing to disease progression and may lead to the development of acute-on-chronic liver failure (ACLF) ( 1 ). (frontiersin.org)
- Especially, spontaneous bacterial peritonitis (SBP) is one of the most frequent infections in cirrhosis and therefore a trigger for ACLF ( 2 ). (frontiersin.org)
- You can also get sore throat for a lot of other reasons - from viral or bacterial infections, dry air, smoking exposure to irritants or too much cheering at a game. (1staid.ca)
Genus4
- Originally belonged to the genus Acinetobacter to the family of Neisseriaceae. (acinetobacterbaumannii.com)
- Malaria is a parasitic infection caused by a protozoan of the genus Plasmodium, transmitted to humans by the bite of a mosquito (Anopheles). (medical-actu.com)
- The genus Neisseria belongs to the family Neisseriaceae. (1staid.ca)
- Pathogenic species within this class are the Neisseriaceae ( gonorrhea and meningoencephalitis) and species of the genus Burkholderia . (wikidoc.org)
Neisseriales1
- Phylogenomics and molecular signatures for the order Neisseriales: proposal for division of the order Neisseriales into the emended family Neisseriaceae and Chromobacteriaceae fam. (mcmaster.ca)
Otitis media1
- H parainfluenzae is capable of causing a variety of infections such as IE, otitis media , abscesses, and pneumonia, although it is an uncommon cause of these infections. (medscape.com)
Pneumonia2
- To this end, we collected clinical data and characterised the nasopharyngeal microbiota of 154 children (4 weeks-5 years old) hospitalised for a LRTI (bronchiolitis, pneumonia, wheezing illness or mixed infection) at admission and 4-8 weeks later. (ersjournals.com)
- Pneumonia is technically a kind of pneumonitis since the infection causes inflammation. (1staid.ca)
Species2
- HACEK Infections The HACEK group ( Haemophilus species, Aggregatibacter actinomycetemcomitans , Cardiobacterium hominis , Eikenella corrodens , Kingella kingae ) includes weakly. (msdmanuals.com)
- Pasteurellaceae and Neisseriaceae species tend to select for genes from close relatives. (wikipedia.org)
Endocarditis1
- The pathogenesis of HACEK endocarditis is thought to be due to colonization of the oropharynx with bacteria that reach the vascular space following either trauma or local infection. (medscape.com)
Gram-negative coccobacilli1
- Kingella , which belong to the family Neisseriaceae, are short, nonmotile, gram-negative coccobacilli that occur in pairs or short chains. (msdmanuals.com)
Kingae4
- Kingella kingae ,also is a member of the Neisseriaceae but unlike Eikenella, it usually can be recovered on Thayer-Martin agar. (medscape.com)
- Assess the treatment of contacts of children with invasive K. kingae infections. (cdc.gov)
- Because of the improved culture methods and sensitive nucleic acid amplification assays developed in recent years, Kingella kingae , a gram-negative coccobacillus of the Neisseriaceae family, is increasingly recognized as an invasive pathogen of early childhood. (cdc.gov)
- Although most cases of invasive Kingella kingae infections are sporadic, clusters of invasive disease have been detected among attendees of daycare centers in Israel, Europe, and the United States. (cdc.gov)
Urinary tract inf1
- In addition, rare cases of endometritis and urinary tract infection have been identified. (medscape.com)
Kingella1
- Diagnosis of Kingella infections requires laboratory isolation from fluids or tissues thought to be infected. (msdmanuals.com)
Meningitis1
- More than 90 percent of meningococcal infections worldwide are caused by certain serotypes , types A, B, C, W135 and Y. In Germany fall ill each year about 700 to 800 people at a meningococcal meningitis (also called cerebrospinal meningitis epidemic and communicable stiff neck ), to about 70 percent by the serotype B is caused. (zxc.wiki)
Gonorrhea1
- Hasan studies the Neisseriaceae bacteria, which includes the strain that causes the sexually transmitted infection gonorrhea, and works with Magdalene So in the department of immunobiology. (arizona.edu)
Family3
- It is a member of the Neisseriaceae family, however can not be recovered on selective media for Neisseria spp such as Thayer-Martin agar. (medscape.com)
- Infections with bacteria of the family ANAPLASMATACEAE. (uchicago.edu)
- Background Laribacter hongkongensis is a newly discovered, facultative anaerobic, Gram-negative, motile, sea gull-shaped rod that belongs to the Neisseriaceae family of β-proteobacteria. (mdm2signals.com)
Invasive3
- Invasive infections commonly occur in the setting of trauma, underlying structural heart disease, malignancy, and other immunocompromised states. (medscape.com)
- No Good Deed Goes Unpunished: Eculizumab and Invasive Neisserial Infections. (umassmed.edu)
- The prevalence rate in healthy children during the second year of life ranges between 10 percent and 12 percent, which coincides with the peak attack rate of invasive infections. (cdc.gov)
Acinetobacter3
- Risk factors for infection by Acinetobacter antibiotic pre-treatment and / or surgery as well as the use of ventilators and other medical instruments have been identified. (acinetobacterbaumannii.com)
- Severe wound infection and multidrug-resistant Acinetobacter baumannii by Osteomyelititiden were diagnosed among American soldiers who had been wounded in combat operations in Iraq and Afghanistan. (acinetobacterbaumannii.com)
- Sulbactam does not possess any useful antibacterial activity, except against Neisseriaceae and Acinetobacter . (alniche.com)
Diseases1
- Other common diseases are urinary tract infections, wound infections, and sepsis. (acinetobacterbaumannii.com)
Treating infections caused1
- Colistin (in Germany not commercially available) is used for treating infections caused by pan-resistant strains. (acinetobacterbaumannii.com)
Humans1
- The only source of infection is humans . (wikilectures.eu)
Septic arthritis1
- The most common skeletal infection is septic arthritis, which most frequently affects large, weight-bearing joints, especially the knee and ankle. (msdmanuals.com)
Variety of infections1
- Seven hundred twenty-three isolates of Moraxella catarrhalis obtained from outpatients with a variety of infections in 30 medical centers in the United States between 1 November 1994 and 30 April 1995 were characterized in a central laboratory. (ox.ac.uk)
Abscesses1
- E corrodens can cause IE and is associated with infection following traumatic inoculation from the oral cavity and is found in up to 42% of abscesses from human bite wounds. (medscape.com)
Colonization1
- thus, young children are prone to colonization and infection by encapsulated bacteria. (cdc.gov)
Serious infections1
- The sulbactam monotherapy is not recommended for serious infections. (acinetobacterbaumannii.com)
Causative1
- Until 2012, Microvirgula aerodenitrificans has not been described as a causative organism of clinical infection. (kenyon.edu)
Strains3
- UNASYN is indicated for the treatment of infections due to susceptible strains of the designated microorganisms in the conditions listed below. (pfizermedicalinformation.com)
- Skin and Skin Structure Infections caused by beta-lactamase producing strains of Staphylococcus aureus , Escherichia coli , 2 Klebsiella spp. (pfizermedicalinformation.com)
- Intra-Abdominal Infections caused by beta-lactamase producing strains of Escherichia coli , Klebsiella spp. (pfizermedicalinformation.com)
Susceptible2
- While UNASYN is indicated only for the conditions listed above, infections caused by ampicillin-susceptible organisms are also amenable to treatment with UNASYN due to its ampicillin content. (pfizermedicalinformation.com)
- Therefore, mixed infections caused by ampicillin-susceptible organisms and beta-lactamase producing organisms susceptible to UNASYN should not require the addition of another antibacterial. (pfizermedicalinformation.com)
Multiply1
- Because the bacteria are very sensitive to the environment, they do not multiply in the urine and thus the infection does not spread to the bladder or kidneys. (wikilectures.eu)
Sulbactam1
- To reduce the development of drug-resistant bacteria and maintain the effectiveness of ampicillin and sulbactam for injection and other antibacterial drugs, ampicillin and sulbactam for injection should be used only to treat infections that are proven or strongly suspected to be caused by bacteria. (nih.gov)
Organisms2
- Appropriate culture and susceptibility tests should be performed before treatment in order to isolate and identify the organisms causing infection and to determine their susceptibility to UNASYN. (pfizermedicalinformation.com)
- Therapy may be instituted prior to obtaining the results from bacteriological and susceptibility studies when there is reason to believe the infection may involve any of the beta-lactamase producing organisms listed above in the indicated organ systems. (pfizermedicalinformation.com)
Seasonal1
- Infection has a seasonal distribution, with more cases in fall and winter. (msdmanuals.com)
Inflammation2
- Acute conjunctival inflammation in the newborn, usually caused by maternal gonococcal infection. (wakehealth.edu)
- But systemic inflammation can also be found in the absence of a confirmed infection. (frontiersin.org)
Virulence1
- The Type IV Secretion System Effector Protein CirA Stimulates the GTPase Activity of RhoA and Is Required for Virulence in a Mouse Model of Coxiella burnetii Infection. (jefferson.edu)
Group1
- CONCLUSION: Based on greater sphenoidal sinus involvement, a deeper anatomical area is more vulnerable to fungal infection in the geriatric group than in the non-geriatric group. (bvsalud.org)
Therapy1
- Efficacy of ertapenem for consolidation therapy of extended-spectrum beta-lactamase-producing gram-negative infections: a case series report. (rush.edu)
Case1
- A case of infection-associated antiproteinase-3-negative cytoplasmic antineutrophil cytoplasmic antibody pauci-immune focal necrotizing glomerulonephritis. (rush.edu)