Disappearance of a neoplasm or neoplastic state without the intervention of therapy.
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Neoplasms containing cyst-like formations or producing mucin or serum.
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
Tumors or cancer of the SKIN.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
Tumors or cancers of the KIDNEY.
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Tumors or cancer of the LUNG.
An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)
Statistical models in which the value of a parameter for a given value of a factor is assumed to be equal to a + bx, where a and b are constants. The models predict a linear regression.
Tumors or cancer of the THYROID GLAND.
Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.
Tumors or cancer of the LIVER.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
DNA present in neoplastic tissue.

Suppression of Moloney sarcoma virus immunity following sensitization with attenuated virus. (1/225)

Murine sarcoma virus (Moloney strain) (MSV-M)-induced tumors are unusual in that they regularly appear less than 2 weeks after virus inoculation, progress for 1 to 2 weeks, and are rejected by normal adult BALB/c mice. Rejectio leaves the animals immune to tumor induction. In the present study, presensitization of normal adult BALB/c mice with attenuated MSV-M resulted in an altered pattern of tumor immunity. Injection of active MSV-M into the presensitized animals resulted in tumor induction and rejection similar to that observed in normal animals, but rejection failed to produce protection against the secondary inoculation with MSV-M. After the second inoculation with active MSV-M, tumors appeared and progressed but ultimately were rejected. Over 80% of the mice died, 25% after the primary challenge and the remainder after the secondary challenge. At death, all mice had histological evidence of leukemia which was the probable cause of death. The animals that died following the secondary challenge also had evidence of disseminated MSV-M. Solid tumor nodules were found in skeletal muscle distant from the original site of inoculation, and active MSV-M was isolated from spleen and lungs. The possibility that the results were produced by specific suppression of MSV-Moloney leukemia virus immunity is discussed.  (+info)

Natural history of dysplasia of the uterine cervix. (2/225)

BACKGROUND: A historical cohort of Toronto (Ontario, Canada) women whose Pap smear histories were recorded at a major cytopathology laboratory provided the opportunity to study progression and regression of cervical dysplasia in an era (1962-1980) during which cervical squamous lesions were managed conservatively. METHODS: Actuarial and Cox's survival analyses were used to estimate the rates and relative risks of progression and regression of mild (cervical intraepithelial neoplasia 1 [CIN1]) and moderate (CIN2) dysplasias. In addition, more than 17,000 women with a history of Pap smears between 1970 and 1980 inclusive and who were diagnosed as having mild, moderate, or severe dysplasia were linked to the Ontario Cancer Registry for the outcome of any subsequent cervical cancers occurring through 1989. RESULTS: Both mild and moderate dysplasias were more likely to regress than to progress. The risk of progression from mild to severe dysplasia or worse was only 1% per year, but the risk of progression from moderate dysplasia was 16% within 2 years and 25% within 5 years. Most of the excess risk of cervical cancer for severe and moderate dysplasias occurred within 2 years of the initial dysplastic smear. After 2 years, in comparison with mild dysplasia, the relative risks for progression from severe or moderate dysplasia to cervical cancer in situ or worse was 4.2 (95% confidence interval [CI] = 3.0-5.7) and 2.5 (95% CI = 2.2-3.0), respectively. CONCLUSION: The risk of progression for moderate dysplasia was intermediate between the risks for mild and severe dysplasia; thus, the moderate category may represent a clinically useful distinction. The majority of untreated mild dysplasias were recorded as regressing to yield a normal smear within 2 years.  (+info)

Keratoacanthomas have an immunosuppressive cytokine environment of increased IL-10 and decreased GM-CSF compared to squamous cell carcinomas. (3/225)

To investigate the relationship between keratoacanthoma (KA) and squamous cell carcinoma (SCC), cytokine mRNA in 12 KA and eight SCC were compared. Normal skin was also studied. Reverse transcription polymerase chain reaction (RT-PCR) was used to quantitate mRNA in each sample utilizing DNA standards. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as an internal control, and CD3delta as an indication of the T-cell infiltrate. KAs showed a significant increase in interleukin (IL)-10, and a decrease in granulocyte macrophage colony-stimulating factor (GM-CSF) mRNA compared to SCCs. CD3delta mRNA was also increased in the KAs. There was no difference between KAs and SCCs in expression of lymphotoxin-alpha, IL-2, interferon-gamma (IFN-gamma), IL-13, transforming growth factor-beta (TGF-beta), or the pro-inflammatory cytokines IL-8 or tumour necrosis factor-alpha (TNF-alpha). These results indicate that KAs spontaneously resolve in an immunosuppressive environment. KAs grow rapidly over a period of weeks and then involute. It is possible that a suppressed immune response enables unimpeded growth and that the KA cells rapidly undergo the finite number of cell divisions of which they are capable, and then die without reaching immortality.  (+info)

CD30-CD30 ligand interaction in primary cutaneous CD30(+) T-cell lymphomas: A clue to the pathophysiology of clinical regression. (4/225)

Primary CD30(+) cutaneous T-cell lymphomas (CTCLs) represent a spectrum of non-Hodgkin's lymphomas (NHLs) that have been well defined at the clinical, histologic, and immunologic level. This group, which includes 2 main entities (large cell lymphoma and lymphomatoid papulosis [LyP]) and borderline cases, is characterized by the expression of CD30 antigen by neoplastic large cells at presentation, possible spontaneous regression of the skin lesions, and generally favorable clinical course. Although the functional relevance of CD30 and its natural ligand (CD30L) expression in most cases of NHL is presently undefined, previous studies indicate that CD30L is likely to mediate reduction of proliferation in CD30(+) anaplastic large-cell NHL. No information is currently available concerning the expression of CD30L in primary CD30(+) CTCLs. In this study, we investigated the immunophenotypic and genotypic expression of CD30 and CD30L in different developmental phases of skin lesions (growing v spontaneously regressing). By immunohistochemistry, CD30L expression was detected in regressing lesions only; by molecular analysis, the expression of CD30L was clearly higher in regressing lesions than in growing ones. CD30L, while expressed by some small lymphocytes, was most often coexpressed by CD30(+) neoplastic large cells, as demonstrated by 2-color immunofluorescence and by immunohistochemistry on paraffin sections. Taken together, these data suggest that CD30-CD30L interaction may play a role in the pathobiology of primary cutaneous CD30(+) lymphoproliferative disorders. In particular, CD30L (over)expression might have a major role in the mechanism of self-regression of skin lesions, the most distinctive clinical feature of this cutaneous lymphoma subtype.  (+info)

Spontaneous necrosis of parathyroid adenoma: biochemical and imaging follow-up for two years. (5/225)

We report a patient with a biochemically and radiologically confirmed parathyroid adenoma, which underwent spontaneous resolution by necrosis. The patient was followed-up over the subsequent two years during which time the tumour and hypercalcaemia recurred. Sequential radiological and biochemical changes at the time of diagnosis, spontaneous necrosis and recurrence are documented fully.  (+info)

Metastasis formation of Yoshida sarcoma heterotransplanted in adult golden hamsters treated with anti-hamster thymocyte serum. (6/225)

Growth of Yoshida sarcoma cells heterotransplanted in adult golden hamsters treated with antithymocyte serum was investigated. Control animals were grafted with or without hydrocoritisone conditioning. In the antithymocyte serum-treated group, tumors were produced in cheek pouches and grew progressively in size until Day 21 with no sign of regression. Little host reaction was noticed histologically around the tumor grafts throughout the course. Distant metastases were revealed at autopsy in 9 of 12 animals from Day 14 of inoculation on, and all the experimental animals died by Day 23. Six of the 9 hamsters with metastases died of tumor. By means of the back-transplantation test, the metastatic tumor cells were shown to be consistent with Yoshida sarcoma cells. In hydrocortisone-treated and untreated groups, the tumor size reached a maximum on Day 21 and Day 5, respectively, and then regression followed. No metastasis was detected in either control group.  (+info)

Natural course of neuroblastoma detected by mass screening: s 5-year prospective study at a single institution. (7/225)

PURPOSE: To describe various favorable courses of neuroblastoma (NBL) detected by mass screening and to present our observation program as a temporary treatment option, to be used until a final decision is made regarding the mass screening program for 6-month-old infants. PATIENTS AND METHODS: Between October 1993 and November 1999, 26 of 51 patients with NBL detected by mass screening were enrolled in our observation program. The criteria for observation included urinary vanillylmandelic acid (VMA) and homovanillic acid (HVA) levels less than 50 microg/mg creatinine, smaller tumor size (< 5.0 cm), preoperative status, and granted informed consent. Patients were divided into four groups according to changes in urinary VMA and HVA values and tumor size. Patients who no longer fulfilled criteria underwent surgery. RESULTS: The observation period ranged from 4 to 73 months. Urinary VMA and HVA levels decreased in 19 of 26 patients, often by age 16 months. Eighteen patients had regressing tumors, and in 10 of these cases, the tumor was undetectable or barely detectable by imaging techniques. Four patients younger than 12 months had increased tumor marker levels and tumor volume, histologically reflecting neuroblastic proliferation. The remaining three patients, all older than 18 months, had varied tumor marker levels but increased tumor volume, histologically reflecting an increase in Schwann cells. No upgrading of tumor stage or unfavorable biologic factor was noted in any patient. CONCLUSION: None of our patients showed evidence of transition from favorable to unfavorable prognosis, a finding that points to a reduction in the significance of screening as a public health measure. Until results of ongoing screening trials involving older patients have been evaluated, the observation program can be used as a temporary measure to avoid, with little risk, unnecessary surgical intervention.  (+info)

Cross-presentation of tumor antigens to effector T cells is sufficient to mediate effective immunotherapy of established intracranial tumors. (8/225)

The systemic adoptive transfer of tumor-sensitized T cells, activated ex vivo, can eliminate established intracranial tumors. Regression of MHC class II negative MCA 205 fibrosarcomas occurs optimally following adoptive transfer of both CD4 and CD8 tumor-sensitized T cells, indicating an important function for tumor-infiltrating APC. Here, we demonstrate that during an effector response, indirect presentation of tumor Ags to transferred T cells is sufficient to mediate intracranial tumor regression. BALB/c --> CB6F1 (H-2bxd) bone marrow chimeras were challenged with the MCA 205 fibrosarcoma (H-2b). The tumor grew progressively in the H-2b-tolerant chimeras and stimulated an immune response in tumor-draining lymph nodes. Tumor-sensitized lymph node T cells were activated ex vivo with anti-CD3 and IL-2, then adoptively transferred to sublethally irradiated BALB/c or C57BL/6 recipients bearing established intracranial MCA 205 tumors. The transferred T cells eradicated MCA 205 tumors in BALB/c recipients and demonstrated tumor specificity, but had no therapeutic efficacy in the C57BL/6 recipients. These data establish that tumor-associated host cell constituents provide sufficient Ag presentation to drive effector T cell function in the complete absence of direct tumor recognition. This effector mechanism has an evident capacity to remain operative in circumstances of immune escape, where the tumor does not express the relevant MHC molecules, and may have importance even at times when direct CTL recognition also remains operative.  (+info)

Spontaneous neoplasm regression is a rare and somewhat controversial phenomenon in which a tumor or malignancy appears to decrease in size or disappear without any treatment or with treatment that is typically not expected to produce such an effect. This can occur through various mechanisms, including immune-mediated processes, apoptosis (programmed cell death), differentiation of cancer cells into normal cells, and angiogenesis inhibition (preventing the growth of new blood vessels that feed the tumor).

Spontaneous regression of neoplasms is not well understood and is considered unpredictable. It has been reported in various types of cancers, including neuroblastoma, melanoma, renal cell carcinoma, and others. However, it should be noted that spontaneous regression does not imply a cure, as the tumor may still recur or metastasize later on.

In summary, spontaneous neoplasm regression refers to the partial or complete disappearance of a malignancy without any specific treatment or with treatment that is not typically associated with such an effect.

Regression analysis is a statistical technique used in medicine, as well as in other fields, to examine the relationship between one or more independent variables (predictors) and a dependent variable (outcome). It allows for the estimation of the average change in the outcome variable associated with a one-unit change in an independent variable, while controlling for the effects of other independent variables. This technique is often used to identify risk factors for diseases or to evaluate the effectiveness of medical interventions. In medical research, regression analysis can be used to adjust for potential confounding variables and to quantify the relationship between exposures and health outcomes. It can also be used in predictive modeling to estimate the probability of a particular outcome based on multiple predictors.

Pancreatic neoplasms refer to abnormal growths in the pancreas that can be benign or malignant. The pancreas is a gland located behind the stomach that produces hormones and digestive enzymes. Pancreatic neoplasms can interfere with the normal functioning of the pancreas, leading to various health complications.

Benign pancreatic neoplasms are non-cancerous growths that do not spread to other parts of the body. They are usually removed through surgery to prevent any potential complications, such as blocking the bile duct or causing pain.

Malignant pancreatic neoplasms, also known as pancreatic cancer, are cancerous growths that can invade and destroy surrounding tissues and organs. They can also spread (metastasize) to other parts of the body, such as the liver, lungs, or bones. Pancreatic cancer is often aggressive and difficult to treat, with a poor prognosis.

There are several types of pancreatic neoplasms, including adenocarcinomas, neuroendocrine tumors, solid pseudopapillary neoplasms, and cystic neoplasms. The specific type of neoplasm is determined through various diagnostic tests, such as imaging studies, biopsies, and blood tests. Treatment options depend on the type, stage, and location of the neoplasm, as well as the patient's overall health and preferences.

Neoplasms are abnormal growths of cells or tissues in the body that serve no physiological function. They can be benign (non-cancerous) or malignant (cancerous). Benign neoplasms are typically slow growing and do not spread to other parts of the body, while malignant neoplasms are aggressive, invasive, and can metastasize to distant sites.

Neoplasms occur when there is a dysregulation in the normal process of cell division and differentiation, leading to uncontrolled growth and accumulation of cells. This can result from genetic mutations or other factors such as viral infections, environmental exposures, or hormonal imbalances.

Neoplasms can develop in any organ or tissue of the body and can cause various symptoms depending on their size, location, and type. Treatment options for neoplasms include surgery, radiation therapy, chemotherapy, immunotherapy, and targeted therapy, among others.

Neoplasms: Neoplasms refer to abnormal growths of tissue that can be benign (non-cancerous) or malignant (cancerous). They occur when the normal control mechanisms that regulate cell growth and division are disrupted, leading to uncontrolled cell proliferation.

Cystic Neoplasms: Cystic neoplasms are tumors that contain fluid-filled sacs or cysts. These tumors can be benign or malignant and can occur in various organs of the body, including the pancreas, ovary, and liver.

Mucinous Neoplasms: Mucinous neoplasms are a type of cystic neoplasm that is characterized by the production of mucin, a gel-like substance produced by certain types of cells. These tumors can occur in various organs, including the ovary, pancreas, and colon. Mucinous neoplasms can be benign or malignant, and malignant forms are often aggressive and have a poor prognosis.

Serous Neoplasms: Serous neoplasms are another type of cystic neoplasm that is characterized by the production of serous fluid, which is a thin, watery fluid. These tumors commonly occur in the ovary and can be benign or malignant. Malignant serous neoplasms are often aggressive and have a poor prognosis.

In summary, neoplasms refer to abnormal tissue growths that can be benign or malignant. Cystic neoplasms contain fluid-filled sacs and can occur in various organs of the body. Mucinous neoplasms produce a gel-like substance called mucin and can also occur in various organs, while serous neoplasms produce thin, watery fluid and commonly occur in the ovary. Both mucinous and serous neoplasms can be benign or malignant, with malignant forms often being aggressive and having a poor prognosis.

Logistic models, specifically logistic regression models, are a type of statistical analysis used in medical and epidemiological research to identify the relationship between the risk of a certain health outcome or disease (dependent variable) and one or more independent variables, such as demographic factors, exposure variables, or other clinical measurements.

In contrast to linear regression models, logistic regression models are used when the dependent variable is binary or dichotomous in nature, meaning it can only take on two values, such as "disease present" or "disease absent." The model uses a logistic function to estimate the probability of the outcome based on the independent variables.

Logistic regression models are useful for identifying risk factors and estimating the strength of associations between exposures and health outcomes, adjusting for potential confounders, and predicting the probability of an outcome given certain values of the independent variables. They can also be used to develop clinical prediction rules or scores that can aid in decision-making and patient care.

Skin neoplasms refer to abnormal growths or tumors in the skin that can be benign (non-cancerous) or malignant (cancerous). They result from uncontrolled multiplication of skin cells, which can form various types of lesions. These growths may appear as lumps, bumps, sores, patches, or discolored areas on the skin.

Benign skin neoplasms include conditions such as moles, warts, and seborrheic keratoses, while malignant skin neoplasms are primarily classified into melanoma, squamous cell carcinoma, and basal cell carcinoma. These three types of cancerous skin growths are collectively known as non-melanoma skin cancers (NMSCs). Melanoma is the most aggressive and dangerous form of skin cancer, while NMSCs tend to be less invasive but more common.

It's essential to monitor any changes in existing skin lesions or the appearance of new growths and consult a healthcare professional for proper evaluation and treatment if needed.

Medical Definition:

"Risk factors" are any attribute, characteristic or exposure of an individual that increases the likelihood of developing a disease or injury. They can be divided into modifiable and non-modifiable risk factors. Modifiable risk factors are those that can be changed through lifestyle choices or medical treatment, while non-modifiable risk factors are inherent traits such as age, gender, or genetic predisposition. Examples of modifiable risk factors include smoking, alcohol consumption, physical inactivity, and unhealthy diet, while non-modifiable risk factors include age, sex, and family history. It is important to note that having a risk factor does not guarantee that a person will develop the disease, but rather indicates an increased susceptibility.

Multiple primary neoplasms refer to the occurrence of more than one primary malignant tumor in an individual, where each tumor is unrelated to the other and originates from separate cells or organs. This differs from metastatic cancer, where a single malignancy spreads to multiple sites in the body. Multiple primary neoplasms can be synchronous (occurring at the same time) or metachronous (occurring at different times). The risk of developing multiple primary neoplasms increases with age and is associated with certain genetic predispositions, environmental factors, and lifestyle choices such as smoking and alcohol consumption.

Kidney neoplasms refer to abnormal growths or tumors in the kidney tissues that can be benign (non-cancerous) or malignant (cancerous). These growths can originate from various types of kidney cells, including the renal tubules, glomeruli, and the renal pelvis.

Malignant kidney neoplasms are also known as kidney cancers, with renal cell carcinoma being the most common type. Benign kidney neoplasms include renal adenomas, oncocytomas, and angiomyolipomas. While benign neoplasms are generally not life-threatening, they can still cause problems if they grow large enough to compromise kidney function or if they undergo malignant transformation.

Early detection and appropriate management of kidney neoplasms are crucial for improving patient outcomes and overall prognosis. Regular medical check-ups, imaging studies, and urinalysis can help in the early identification of these growths, allowing for timely intervention and treatment.

A "second primary neoplasm" is a distinct, new cancer or malignancy that develops in a person who has already had a previous cancer. It is not a recurrence or metastasis of the original tumor, but rather an independent cancer that arises in a different location or organ system. The development of second primary neoplasms can be influenced by various factors such as genetic predisposition, environmental exposures, and previous treatments like chemotherapy or radiation therapy.

It is important to note that the definition of "second primary neoplasm" may vary slightly depending on the specific source or context. In general medical usage, it refers to a new, separate cancer; however, in some research or clinical settings, there might be more precise criteria for defining and diagnosing second primary neoplasms.

Retrospective studies, also known as retrospective research or looking back studies, are a type of observational study that examines data from the past to draw conclusions about possible causal relationships between risk factors and outcomes. In these studies, researchers analyze existing records, medical charts, or previously collected data to test a hypothesis or answer a specific research question.

Retrospective studies can be useful for generating hypotheses and identifying trends, but they have limitations compared to prospective studies, which follow participants forward in time from exposure to outcome. Retrospective studies are subject to biases such as recall bias, selection bias, and information bias, which can affect the validity of the results. Therefore, retrospective studies should be interpreted with caution and used primarily to generate hypotheses for further testing in prospective studies.

Lung neoplasms refer to abnormal growths or tumors in the lung tissue. These tumors can be benign (non-cancerous) or malignant (cancerous). Malignant lung neoplasms are further classified into two main types: small cell lung carcinoma and non-small cell lung carcinoma. Lung neoplasms can cause symptoms such as cough, chest pain, shortness of breath, and weight loss. They are often caused by smoking or exposure to secondhand smoke, but can also occur due to genetic factors, radiation exposure, and other environmental carcinogens. Early detection and treatment of lung neoplasms is crucial for improving outcomes and survival rates.

Adenocarcinoma, mucinous is a type of cancer that begins in the glandular cells that line certain organs and produce mucin, a substance that lubricates and protects tissues. This type of cancer is characterized by the presence of abundant pools of mucin within the tumor. It typically develops in organs such as the colon, rectum, lungs, pancreas, and ovaries.

Mucinous adenocarcinomas tend to have a distinct appearance under the microscope, with large pools of mucin pushing aside the cancer cells. They may also have a different clinical behavior compared to other types of adenocarcinomas, such as being more aggressive or having a worse prognosis in some cases.

It is important to note that while a diagnosis of adenocarcinoma, mucinous can be serious, the prognosis and treatment options may vary depending on several factors, including the location of the cancer, the stage at which it was diagnosed, and the individual's overall health.

I'm sorry for any confusion, but "Linear Models" is actually a term from the field of statistics and machine learning, rather than medicine. A linear model is a type of statistical model that is used to analyze the relationship between two or more variables. In a linear model, the relationship between the dependent variable (the outcome or result) and the independent variable(s) (the factors being studied) is assumed to be linear, meaning that it can be described by a straight line on a graph.

The equation for a simple linear model with one independent variable (x) and one dependent variable (y) looks like this:

y = β0 + β1*x + ε

In this equation, β0 is the y-intercept or the value of y when x equals zero, β1 is the slope or the change in y for each unit increase in x, and ε is the error term or the difference between the actual values of y and the predicted values of y based on the linear model.

Linear models are widely used in medical research to study the relationship between various factors (such as exposure to a risk factor or treatment) and health outcomes (such as disease incidence or mortality). They can also be used to adjust for confounding variables, which are factors that may influence both the independent variable and the dependent variable, and thus affect the observed relationship between them.

Thyroid neoplasms refer to abnormal growths or tumors in the thyroid gland, which can be benign (non-cancerous) or malignant (cancerous). These growths can vary in size and may cause a noticeable lump or nodule in the neck. Thyroid neoplasms can also affect the function of the thyroid gland, leading to hormonal imbalances and related symptoms. The exact causes of thyroid neoplasms are not fully understood, but risk factors include radiation exposure, family history, and certain genetic conditions. It is important to note that most thyroid nodules are benign, but a proper medical evaluation is necessary to determine the nature of the growth and develop an appropriate treatment plan.

Myeloproliferative disorders (MPDs) are a group of rare, chronic blood cancers that originate from the abnormal proliferation or growth of one or more types of blood-forming cells in the bone marrow. These disorders result in an overproduction of mature but dysfunctional blood cells, which can lead to serious complications such as blood clots, bleeding, and organ damage.

There are several subtypes of MPDs, including:

1. Chronic Myeloid Leukemia (CML): A disorder characterized by the overproduction of mature granulocytes (a type of white blood cell) in the bone marrow, leading to an increased number of these cells in the blood. CML is caused by a genetic mutation that results in the formation of the BCR-ABL fusion protein, which drives uncontrolled cell growth and division.
2. Polycythemia Vera (PV): A disorder characterized by the overproduction of all three types of blood cells - red blood cells, white blood cells, and platelets - in the bone marrow. This can lead to an increased risk of blood clots, bleeding, and enlargement of the spleen.
3. Essential Thrombocythemia (ET): A disorder characterized by the overproduction of platelets in the bone marrow, leading to an increased risk of blood clots and bleeding.
4. Primary Myelofibrosis (PMF): A disorder characterized by the replacement of normal bone marrow tissue with scar tissue, leading to impaired blood cell production and anemia, enlargement of the spleen, and increased risk of infections and bleeding.
5. Chronic Neutrophilic Leukemia (CNL): A rare disorder characterized by the overproduction of neutrophils (a type of white blood cell) in the bone marrow, leading to an increased number of these cells in the blood. CNL can lead to an increased risk of infections and organ damage.

MPDs are typically treated with a combination of therapies, including chemotherapy, targeted therapy, immunotherapy, and stem cell transplantation. The choice of treatment depends on several factors, including the subtype of MPD, the patient's age and overall health, and the presence of any comorbidities.

Liver neoplasms refer to abnormal growths in the liver that can be benign or malignant. Benign liver neoplasms are non-cancerous tumors that do not spread to other parts of the body, while malignant liver neoplasms are cancerous tumors that can invade and destroy surrounding tissue and spread to other organs.

Liver neoplasms can be primary, meaning they originate in the liver, or secondary, meaning they have metastasized (spread) to the liver from another part of the body. Primary liver neoplasms can be further classified into different types based on their cell of origin and behavior, including hepatocellular carcinoma, cholangiocarcinoma, and hepatic hemangioma.

The diagnosis of liver neoplasms typically involves a combination of imaging studies, such as ultrasound, CT scan, or MRI, and biopsy to confirm the type and stage of the tumor. Treatment options depend on the type and extent of the neoplasm and may include surgery, radiation therapy, chemotherapy, or liver transplantation.

A cohort study is a type of observational study in which a group of individuals who share a common characteristic or exposure are followed up over time to determine the incidence of a specific outcome or outcomes. The cohort, or group, is defined based on the exposure status (e.g., exposed vs. unexposed) and then monitored prospectively to assess for the development of new health events or conditions.

Cohort studies can be either prospective or retrospective in design. In a prospective cohort study, participants are enrolled and followed forward in time from the beginning of the study. In contrast, in a retrospective cohort study, researchers identify a cohort that has already been assembled through medical records, insurance claims, or other sources and then look back in time to assess exposure status and health outcomes.

Cohort studies are useful for establishing causality between an exposure and an outcome because they allow researchers to observe the temporal relationship between the two. They can also provide information on the incidence of a disease or condition in different populations, which can be used to inform public health policy and interventions. However, cohort studies can be expensive and time-consuming to conduct, and they may be subject to bias if participants are not representative of the population or if there is loss to follow-up.

The term "DNA, neoplasm" is not a standard medical term or concept. DNA refers to deoxyribonucleic acid, which is the genetic material present in the cells of living organisms. A neoplasm, on the other hand, is a tumor or growth of abnormal tissue that can be benign (non-cancerous) or malignant (cancerous).

In some contexts, "DNA, neoplasm" may refer to genetic alterations found in cancer cells. These genetic changes can include mutations, amplifications, deletions, or rearrangements of DNA sequences that contribute to the development and progression of cancer. Identifying these genetic abnormalities can help doctors diagnose and treat certain types of cancer more effectively.

However, it's important to note that "DNA, neoplasm" is not a term that would typically be used in medical reports or research papers without further clarification. If you have any specific questions about DNA changes in cancer cells or neoplasms, I would recommend consulting with a healthcare professional or conducting further research on the topic.

... neoplasm recurrence, local MeSH C23.550.727.670 - neoplasm regression, spontaneous MeSH C23.550.727.700 - neoplasm, residual ... neoplasm circulating cells MeSH C23.550.727.650.830 - neoplasm seeding MeSH C23.550.727.650.895 - neoplasms, unknown primary ... neoplasm invasiveness MeSH C23.550.727.645.500 - leukemic infiltration MeSH C23.550.727.650 - neoplasm metastasis MeSH C23.550. ...
... neoplasm regression, spontaneous MeSH G04.335.119.260 - erythrocyte aging MeSH G04.335.122.100 - autocrine communication MeSH ...
There have been rare cases of spontaneous regression of pulmonary metastases without any treatment. As with all these subgroups ... EMC shows the smallest morphological variation between the tumors among all myxoid soft tissue neoplasms. The myxoid matrix has ... Extraskeletal myxoid chondrosarcoma (EMC) is a rare low-grade malignant mesenchymal neoplasm of the soft tissues, that differs ...
2003) "Coley" Spontaneous Regression: Cancer and the Immune System Philadelphia: Xlibris[self-published source]. [1] Hall, ... Coley, William (1949). Neoplasms of Bone. New York: Medical Book Department of Harper & Brothers. pp. 565-570. Chang AE, Shu S ... William B. Coley Award Timeline of immunology Thomas Jessy (2011). "Immunity over inability: The spontaneous regression of ... "Spontaneous regression of pancreatic cancer" Case Reports and Clinical Practice Review 293-296 [5] [6] McCarthy Edward F., MD ( ...
It is preferable not to invoke such powerful immuno-suppressive therapy in most cases of CH in which spontaneous regression of ... histiocytic neoplasm which arises in multiple sites simultaneously. Most lesions previously defined as MH are probably more ... Delayed regression of multiple histiocytomas can occur and lesions can persist for up to 10 months. Recently, several cases of ... In 3 instances regression of these lesions occurred spontaneously within 3-4 weeks. In other instances the metastatic lesions ...
Passeri T, Champagne PO, Bernat AL, Hanakita S, Salle H, Mandonnet E, Froelich S (April 2019). "Spontaneous regression of ... ISBN 978-0-323-32195-2. Meningeal Neoplasms-Advances in Research and Treatment: 2012 Edition: ScholarlyBrief. ScholarlyEditions ... Hensiek AE, Kellerman AJ, Hill JT (August 2000). "Spontaneous regression of a solitary cerebral metastases in renal carcinoma ... Bernat AL, Bonnin S, Labidi M, Aldahak N, Bresson D, Bouazza S, Froelich S (2018). "Regression of Giant Olfactory Groove ...
To stop further growth and to speed regression of lesions in infants with more significant clinical sequelae, treatment with ... These hemangioendotheliomas have 2 growth phases: an initial rapid growth phase, which is followed by a period of spontaneous ... Hemangioendotheliomas are a family of vascular neoplasms of intermediate malignancy. They have been described as masses that ...
DSDD seems to phenotypically overlap with obsessional slowness (see above) and catatonia-like regression occurring in ASD. The ... spontaneous and active maintenance of a posture against gravity mannerisms that are odd, circumstantial caricatures of normal ... neoplasms, head injury, and some metabolic conditions (homocystinuria, diabetic ketoacidosis, hepatic encephalopathy, and ... Ghaziuddin, Mohammad (28 October 2021). "Catatonia: A Common Cause of Late Regression in Autism". Frontiers in Psychiatry. 12: ...
Myotonic dystrophy N segment N-end rule Narrow heritability Natural selection Negative control Neo-Darwinism Neomorph Neoplasm ... altruism Reciprocal cross Recombinant Recombinant clone Recombinant DNA Recon Reduction division Redundant DNA Regression ... Spermatogonium Spermatozoon Spermiogenesis Spina bifida Spindle Spiral cleavage Spirillum Splice site Spliceosome Spontaneous ...
... characterized by discrete papules in a younger age group and a tendency for spontaneous regression. Additionally, some ... neoplasms, and cysts, Virus-related cutaneous conditions, Papillomavirus-associated diseases, All stub articles, Infection- ... related cutaneous condition stubs, Epidermal nevi, neoplasm, cyst stubs). ...
They show a high rate of spontaneous regression, particularly in congenital and early-onset cases. They typically have a deep ... Neoplasms, Anatomical pathology). ... followed by spontaneous regression in early childhood. ...
It was developed after observing that in some cases there was spontaneous regression. Immunotherapy capitalises on this ... which is an assessment based on the microscopic morphology of a neoplasm with haematoxylin and eosin (H&E staining). This ... causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis". J. Immunother. 30 (8): 825-30. ... "Magnetic resonance imaging in the diagnosis and staging of renal and perirenal neoplasms". Radiology. 154 (3): 709-15. doi: ...
This is due to the spontaneous regression of tumors, which generally occurs within 18 to 24 months after diagnosis. In ... Connective and soft tissue neoplasms). ... Because tumor regression is a common characteristic of IM, many ... Treatment with chemotherapy has shown to be effective in promoting tumor regression, but it comes with a risk of toxicities. ... Sometimes, these infantile lesions are untreated in hopes of a spontaneous remission, which means the lesion heals without any ...
Hemangioma on forehead showing signs of early regression Hemangioma on the scalp of a 2-year-old child, in the "rest stage" ... Considering treatment before school begins is, therefore, important if adequate spontaneous improvement has not occurred. Large ... Vascular anomalies are divided into vascular tumors/neoplasms which include infantile hemangiomas, and vascular malformations ... Benign neoplasms, Dermal and subcutaneous growths, Wikipedia medicine articles ready to translate, Cutaneous congenital ...
... one of the myeloproliferative neoplasms or certain other myeloid neoplasms. A disorder of platelet function is called a ... Spontaneous and excessive bleeding can occur because of platelet disorders. This bleeding can be caused by deficient numbers of ... regression following treatment". Acta Haematologica. 87 (1-2): 83-87. doi:10.1159/000204725. PMID 1585777. van Genderen PJ, ... either to prevent spontaneous bleeding (typically at counts below 10×109/L) or in anticipation of medical procedures that will ...
Similar regressions caused by the replication-deficient Sendai virus have been observed in animals with transplanted melanoma ... Its expression is also increased in a wide range of other malignant neoplasms. Factor X (F10) is frequently expressed in normal ... Martin P, Papayannopoulou T (June 1982). "HEL cells: a new human erythroleukemia cell line with spontaneous and induced globin ... It is also overexpressed in some cell lines originating from various malignant neoplasms. Thus, it is highly expressed in ...
Spontaneous regression has been reported in as many as 15% of patients with cervicofacial lymphangioma. Malignant change has ... Lymphatic malformation or lymphangioma is a rare neoplasm or congenital rest that presents in the head and neck region in more ... Whether patients with this neoplasm present in childhood or adulthood, the identification of a mass requires a diagnosis and ... The growth rate of this neoplasm is variable. Slow progression followed by pseudoregression eventually gives rise to ...
... neoplasm recurrence, local MeSH C23.550.727.670 - neoplasm regression, spontaneous MeSH C23.550.727.700 - neoplasm, residual ... neoplasm circulating cells MeSH C23.550.727.650.830 - neoplasm seeding MeSH C23.550.727.650.895 - neoplasms, unknown primary ... neoplasm invasiveness MeSH C23.550.727.645.500 - leukemic infiltration MeSH C23.550.727.650 - neoplasm metastasis MeSH C23.550. ...
The recurrence rate is low, and spontaneous regression has been reported. [43, 44, 45, 46, 47, 48, 49, 50, 51] ... and benign and malignant neoplasms of the minor salivary glands (eg, see Salivary Gland Neoplasms). ... It is an uncommon benign fibrous neoplasm that occurs most commonly in the skin and may be solitary or multifocal. Both ... Reddy SV, Medikonda SK, Konda A, Natta S. A rare benign odontogenic neoplasm: peripheral odontogenic fibroma. BMJ Case Rep. ...
neoplasm regression, spontaneous (1). *progression tumour (1). *regression (5). *skin neoplasms (1) ... The MHC class-II labelling pattern and T- and B-lymphocyte infiltrates were associated with tumor regression. In regressing ... In order to investigate the immune mechanisms involved in regression of canine cutaneous histicytoma (CCH), major ... its relation to tumor regression. Isabel Pires, Paula Rodrigues, Anabela Alves, Felisbina Luisa Queiroga, Filipe Silva, Carlos ...
Spontaneous regression is rare in patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN). An 85-year-old man ... Spontaneous Regression of Blastic Plasmacytoid Dendritic Cell Neoplasm Following Sepsis by Serratia marcescens: A Case Report ... To our knowledge, this is the first reported case of spontaneous regression of BPDCN with a decrease in tumor cells in the bone ... The multiple logistic regression analysis revealed that the independent variables to predict the development of CRRP were: anti ...
We describe spontaneous regression of a cutaneous invasive squamous cell carcinoma and multifocal atypical intraepidermal ... This observation raises questions regarding the GVT in cutaneous neoplasms and potential immunomodulatory effects of ECP. ... Multinucleate cell angiohistiocytoma follows a slowly progressive course, although spontaneous regression has been reported in ... Regression of cutaneous invasive squamous cell carcinoma in a patient with chronic cutaneous graft versus host disease ...
Renal Neoplasms John N. Eble David J. Grignon A diverse array of tumors can arise in the human kidney. In this chapter, these ... There are documented cases of spontaneous regression of metastases (210,211). Recurrence, a decade or more after nephrectomy, ... Congenital mesoblastic nephroma makes up less than 3% of renal neoplasms in children; it is the predominant renal neoplasm in ... The rare tumor known as metanephric adenoma has now been described in detail (47,48,49,50,51,52). Epithelial neoplasms of the ...
A stepwise approach including active surveillance is established as no metastatic potential and spontaneous tumor regression ... A desmoid tumor (aggressive fibromatosis) is a fibroproliferative neoplasm arising from deep connective tissues. ... C) CADD scores for NOTCH2 mutations according to tumor volume changes were plotted with the regression line shown in red (R=- ... 0.716, p=0.013). DANN scores for NOTCH2 mutations were also plotted with the regression line shown in blue (R=-0.831, p=0.006 ...
It is thought that the immune system plays a role in spontaneous regression of keratoacanthomas. Most keratoacanthomas are ... Keratoacanthomas may occur within Muir-Torre syndrome along with sebaceous neoplasms and adenomatous colon carcinoma or other ... A keratoacanthoma is a rapidly growing, well-differentiated neoplasm of squamous epithelium. It assumes a distinct crater- ...
It has the highest rate of spontaneous regression of any pediatric tumor. We performed a retrospective study of pathologic ... Purpose : Neuroblastoma is a malignant neoplasm which arises from primitive sympathetic neuroblasts, and occasionally can ...
Neoplasm Regression, Spontaneous G16.100.870.500 G16.767.500 Neopterin D3.438.733.631.202.500 D3.633.100.733.631.202.500 ... Spontaneous G16.100.870 G16.767 Renal Blood Flow, Effective G8.852.796.700.700 G8.852.725.700 G9.330.190.163.812.700 G9.330. ... Spontaneous G11.561.600.810.263.570 G11.561.790.263.570 Ouabain D4.808.155.580.130.750.600 D4.210.500.155.580.130.750.600 ... Spontaneous Combustion G2.149.767.830 G2.833 G2.842.750.830 Sporidesmins D3.438.473.840 D3.633.100.473.840 Sporozoites G7.700. ...
Neoplasm Regression, Spontaneous G16.100.870.500 G16.767.500 Neopterin D3.438.733.631.202.500 D3.633.100.733.631.202.500 ... Spontaneous G16.100.870 G16.767 Renal Blood Flow, Effective G8.852.796.700.700 G8.852.725.700 G9.330.190.163.812.700 G9.330. ... Spontaneous G11.561.600.810.263.570 G11.561.790.263.570 Ouabain D4.808.155.580.130.750.600 D4.210.500.155.580.130.750.600 ... Spontaneous Combustion G2.149.767.830 G2.833 G2.842.750.830 Sporidesmins D3.438.473.840 D3.633.100.473.840 Sporozoites G7.700. ...
Neoplasm Regression, Spontaneous G16.100.870.500 G16.767.500 Neopterin D3.438.733.631.202.500 D3.633.100.733.631.202.500 ... Spontaneous G16.100.870 G16.767 Renal Blood Flow, Effective G8.852.796.700.700 G8.852.725.700 G9.330.190.163.812.700 G9.330. ... Spontaneous G11.561.600.810.263.570 G11.561.790.263.570 Ouabain D4.808.155.580.130.750.600 D4.210.500.155.580.130.750.600 ... Spontaneous Combustion G2.149.767.830 G2.833 G2.842.750.830 Sporidesmins D3.438.473.840 D3.633.100.473.840 Sporozoites G7.700. ...
Neoplasm Regression, Spontaneous G16.100.870.500 G16.767.500 Neopterin D3.438.733.631.202.500 D3.633.100.733.631.202.500 ... Spontaneous G16.100.870 G16.767 Renal Blood Flow, Effective G8.852.796.700.700 G8.852.725.700 G9.330.190.163.812.700 G9.330. ... Spontaneous G11.561.600.810.263.570 G11.561.790.263.570 Ouabain D4.808.155.580.130.750.600 D4.210.500.155.580.130.750.600 ... Spontaneous Combustion G2.149.767.830 G2.833 G2.842.750.830 Sporidesmins D3.438.473.840 D3.633.100.473.840 Sporozoites G7.700. ...
Neoplasm Regression, Spontaneous G16.100.870.500 G16.767.500 Neopterin D3.438.733.631.202.500 D3.633.100.733.631.202.500 ... Spontaneous G16.100.870 G16.767 Renal Blood Flow, Effective G8.852.796.700.700 G8.852.725.700 G9.330.190.163.812.700 G9.330. ... Spontaneous G11.561.600.810.263.570 G11.561.790.263.570 Ouabain D4.808.155.580.130.750.600 D4.210.500.155.580.130.750.600 ... Spontaneous Combustion G2.149.767.830 G2.833 G2.842.750.830 Sporidesmins D3.438.473.840 D3.633.100.473.840 Sporozoites G7.700. ...
Neoplasm Regression, Spontaneous ...
Partial spontaneous regression may occur resulting in cutaneous atrophy [4]. This disorder has a benign course, however, ... in a series of 117 vascular neoplasm that showed positive expression of WT1, whereas all vascular malformations were negative ... We report the case of a male child born at term from spontaneous delivery after an uncomplicated pregnancy. At birth, the ... Trindade F, Tellechea O, Torrelo A, Requena L, Colmenero I. Wilms tumor 1 expression in vascular neoplasms and vascular ...
The clinical course of both subtypes can vary from spontaneous regression to progressive, malignant disease. HN - 2008; use ... AN - malignant does not refer to neoplasm; do not confuse with the neoplasm ACANTHOMA, DEGOS see ACANTHOMA HN - 2008 BX - Degos ... Neoplasms, Plasma Cell UI - D054219 MN - C04.557.595 MS - Neoplasms associated with a proliferation of a single clone of PLASMA ... This rare neoplasm occurs predominately in adults. HN - 2008 BX - Follicular Dendritic Cell Sarcoma MH - Dendritic Cell Sarcoma ...
The clinical course of both subtypes can vary from spontaneous regression to progressive, malignant disease. HN - 2008; use ... AN - malignant does not refer to neoplasm; do not confuse with the neoplasm ACANTHOMA, DEGOS see ACANTHOMA HN - 2008 BX - Degos ... Neoplasms, Plasma Cell UI - D054219 MN - C04.557.595 MS - Neoplasms associated with a proliferation of a single clone of PLASMA ... This rare neoplasm occurs predominately in adults. HN - 2008 BX - Follicular Dendritic Cell Sarcoma MH - Dendritic Cell Sarcoma ...
The clinical course of both subtypes can vary from spontaneous regression to progressive, malignant disease. HN - 2008; use ... AN - malignant does not refer to neoplasm; do not confuse with the neoplasm ACANTHOMA, DEGOS see ACANTHOMA HN - 2008 BX - Degos ... Neoplasms, Plasma Cell UI - D054219 MN - C04.557.595 MS - Neoplasms associated with a proliferation of a single clone of PLASMA ... This rare neoplasm occurs predominately in adults. HN - 2008 BX - Follicular Dendritic Cell Sarcoma MH - Dendritic Cell Sarcoma ...
The recurrence rate is low, and spontaneous regression has been reported. [39, 40, 41, 42, 43, 44, 45, 46, 47, 48] ... and benign and malignant neoplasms of the minor salivary glands (eg, see Salivary Gland Neoplasms). ... It is an uncommon benign fibrous neoplasm that occurs most commonly in the skin and may be solitary or multifocal. Both ... Reddy SV, Medikonda SK, Konda A, Natta S. A rare benign odontogenic neoplasm: peripheral odontogenic fibroma. BMJ Case Rep. ...
The recurrence rate is low, and spontaneous regression has been reported. [39, 40, 41, 42, 43, 44, 45, 46, 47, 48] ... and benign and malignant neoplasms of the minor salivary glands (eg, see Salivary Gland Neoplasms). ... It is an uncommon benign fibrous neoplasm that occurs most commonly in the skin and may be solitary or multifocal. Both ... Reddy SV, Medikonda SK, Konda A, Natta S. A rare benign odontogenic neoplasm: peripheral odontogenic fibroma. BMJ Case Rep. ...
Spontaneous tumour regression in keratoacanthomas is driven by Wnt/retinoic acid signalling cross-talkZito G, Saotome I, Liu Z ... Carcinoma, Squamous Cell; Dermatology; Epidermis; Keratoacanthoma; Pathology; Skin Neoplasms; Neoplasms, Adnexal and Skin ... Ferro EG, Sun TY, Nguyen DX, Bilguvar K, Ko CJ, Greco V. Spontaneous tumour regression in keratoacanthomas is driven by Wnt/ ... Chapter 20a Key diagnostic features of additional soft tissue neoplasmsKo C, Ferringer T. Chapter 20a Key diagnostic features ...
... and spontaneous pneumothoraces in nine patients (10%). Internal mammary lymphadenopathy was observed in 48 patients (52%) and ... Using logistic regression analysis, other CT findings did not correlate with histological subtype. ... Pleural Neoplasms / diagnostic imaging* * Pleural Neoplasms / pathology* * Reproducibility of Results * Sensitivity and ... in whom there was no significant delay between CT imaging and histological diagnosis were assessed by logistic regression ...
Spontaneous regression of a conjunctival intraepithelial neoplastic tumor. Arch Ophthalmol. 1989 Oct. 107(10):1490-1. [QxMD ... Neoplasms and related conditions (Chapter 2). In: Ophthalmic Pathology - An Atlas and Textbook. Vol. 1. Philadelphia, Pa: WB ... The regression of recurrent conjunctival papillomas by lymphoblastoid interferon treatment. J Med Assoc Thai. 1990 Jul. 73(7): ... For neoplasms suggestive of malignancy (HIV-positive patients or chronic unilateral conjunctivitis unresponsive to therapy) ...
The majority of patients are treated by hepatic resection, although spontaneous regression has also been described. ... The infiltrative pattern of the mass at the US scan suggested a malignant hepatic neoplasm. The histologic examination of the ... The imaging study by US, during and after the treatment, demonstrated a slow and continuous regression of the lesions of the ... Though the inflammatory pseudotumor onset as clinically silent hepatitis, it could insidiously mimic a malignant neoplasm ( ...
Spontaneous regression of metastatic testicular carcinoma in a patient with bilateral sequential testicular tumor.May 31, 1980 ... Diseases : Cancers: Estrogen Responsive, Testicular Cancer, Testicular Neoplasms. Pharmacological Actions : Apoptotic, Cell ... Spontaneous regression as a burned-out non-seminomatous testicular germ cell tumor.Dec 31, 2018. ... A case of spontaneous regression of metastatic testicular teratoma.Dec 31, 1990. ...
Delayed Onset and Spontaneous Regression of DMBA/TPA-Induced Skin Lesions in Mice Lacking Autoimmune Regulator. Lesko, E. M., ...
Spontaneous regression of anal dysplasia, including HSILs, has also been described. In a randomized clinical trial, HSILs ... Practice parameters for anal squamous neoplasms. Dis Colon Rectum 2012;55(7):735-49. [PMID: 22706125] ... Progression to and spontaneous regression of high-grade anal squamous intraepithelial lesions in HIV-infected and uninfected ...
The background of spontaneous regression of the disease in pubertal period observed in some children remains unclear [2][3][4][ ... KIT mutation analysis in mast cell neoplasms: recommendations of the European Competence Network on Mastocytosis. Leukemia 2015 ... The majority of children are suffering from CM and have a favorable prognosis with spontaneous regression in puberty period. In ... SM with an associated hematological neoplasm (SM‐AHN), aggressive SM (ASM), MC leukemia (MCL), and MC sarcoma (MCS). The ...
  • The clinical differential diagnosis of a fibroma depends on its clinical presentation and location and includes giant cell fibroma, neurofibroma , peripheral giant cell granuloma , schwannoma, granular cell tumor, mucocele , and benign and malignant salivary gland tumors (eg, see Salivary Gland Neoplasms ). (medscape.com)
  • The infiltrative pattern of the mass at the US scan suggested a malignant hepatic neoplasm. (ispub.com)
  • Spontaneous regression of primary malignant melanomas with regional metastases. (revistaendocrino.org)
  • While the terminology implies a benign neoplasm, most if not all fibromas represent reactive focal fibrous hyperplasia due to trauma or local irritation. (medscape.com)
  • It is unclear whether clear cell acanthoma represents a benign neoplasm or a reactive inflammatory dermatosis. (statpearls.com)
  • Immunohistochemical and immunoelectron study of major histocompatibility complex class-II antigen in canine cutaneous histiocytoma: its relation to tumor regression. (illumina.com)
  • Spontaneous regression as a 'burned-out' non-seminomatous testicular germ cell tumor. (greenmedinfo.com)
  • Spontaneous regression of metastatic testicular carcinoma in a patient with bilateral sequential testicular tumor. (greenmedinfo.com)
  • Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases. (kreftfri.no)
  • Although neither population exhibited spontaneous cytotoxicity toward P815 targets, LK treatment induced considerable tumoricidal activity in tumor-bearing Mφ (32 to 80% lysis) but only minimal activity in normal Mφ (8 to 17% lysis). (wustl.edu)
  • Injection of a 1:18 mixture of P815 with either LK-activated normal or tumor-bearing Mφ caused tumor regression after 10 days, and prolonged life until 43 ± 4 days with tumor-bearing Mφ and 39 ± 3 days with normal Mφ. (wustl.edu)
  • These workers are also at increased risk for cutaneous neoplasms, with an odds ratio (OR) of 3.67 for cSCCs, 3.32 for basal cell carcinoma (BCC), and 1.97 for melanoma. (medicalacademic.co.za)
  • 0 download) in the acute 60 neoplasm password Facts of anaesthetic realities. (rollwithitmn.org)
  • 6] Case reports have described AN associated with hematologic malignancies, including acute myeloid leukemia, and even benign gastrointestinal neoplasms. (medscape.com)
  • Spontaneous regression of pulmonary metastases from testicular embryonal carcinoma. (greenmedinfo.com)
  • Preclinical data demonstrate that multiple immunomodulators synergize with radiotherapy to cause the regression of irradiated tumors and, less often, nonirradiated metastases. (aacrjournals.org)
  • As previously described in a prior paper by the same authors ( 1 ), the inflammatory pseudotumor of the liver is a heterogeneous group of disease, a complex of lesions of unknown aetiology and pathogenesis which occupy space and mimic a neoplasm. (ispub.com)
  • A keratoacanthoma is a rapidly growing, well-differentiated neoplasm of squamous epithelium. (logicalimages.com)
  • Eighty patients in whom there was no significant delay between CT imaging and histological diagnosis were assessed by logistic regression analysis to correlate CT and histologic findings. (nih.gov)
  • Keratoacanthomas may occur within Muir-Torre syndrome along with sebaceous neoplasms and adenomatous colon carcinoma or other low-grade internal malignancies. (logicalimages.com)
  • Although the classic presentation of BIA-ALCL is known as late persistent seroma, an atypical manifestation such as spontaneous resorption may occur, as in the current case. (e-aaps.org)
  • Spontaneous regression has been reported in as many as 15% of patients with cervicofacial lymphangioma. (medscape.com)
  • Whether patients with this neoplasm present in childhood or adulthood, the identification of a mass requires a diagnosis and management plan. (medscape.com)
  • Spontaneous regression is rare in patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN). (bvsalud.org)
  • Spontaneous regression: In 20% to 23% of patients with a single lesion, and in up to 7.2% of patients with field cancerisation (presence of multiple AKs surrounded by an area of photodamaged skin) lesions may disappear spontaneously. (medicalacademic.co.za)
  • Using logistic regression analysis, other CT findings did not correlate with histological subtype. (nih.gov)
  • We report a case of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL), which had a history of spontaneous resorption of late seroma before diagnosis. (e-aaps.org)
  • IMTs have been reported in numerous organ systems, but most commonly are encountered within the thorax, usually the lung or tracheobronchial tree, and uncommonly the mediastinum.IMTs show variable biological behavior, ranging from spontaneous regression to locally aggressive behavior, including recurrence after resection and even distant metastatic disease. (elsevierpure.com)
  • It is thought that the immune system plays a role in spontaneous regression of keratoacanthomas. (logicalimages.com)
  • Immune checkpoint inhibitors are drugs currently used for different types of neoplasms, these drugs are associated in a significant percentage with endocrinopathies, however, finding the simultaneous involvement of two endocrine glands is unusual, being this the second reported case in the literature with hypophysitis and adrenalitis. (revistaendocrino.org)
  • It is an uncommon benign fibrous neoplasm that occurs most commonly in the skin and may be solitary or multifocal. (medscape.com)
  • Lymphatic malformation or lymphangioma is a rare neoplasm or congenital rest that presents in the head and neck region in more than 70% of cases. (medscape.com)
  • We assessed the effects of total dose and duration of primaquine regimens on the rate of first P vivax recurrence between day 7 and day 180 by Cox's proportional hazards regression (efficacy analysis). (cdc.gov)
  • The effect of primaquine daily dose on gastrointestinal symptoms on days 5-7 was assessed by modified Poisson regression (tolerability analysis). (cdc.gov)
  • The growth rate of this neoplasm is variable. (medscape.com)
  • We report the case of a male child born at term from spontaneous delivery after an uncomplicated pregnancy. (biomedcentral.com)
  • A case of spontaneous regression of metastatic testicular teratoma. (greenmedinfo.com)
  • In secondary echinococcosis, larval tissue spreads from the primary site and new cysts develop after spontaneous or trauma-induced cyst rupture or after release of viable parasite material during invasive treatment procedures. (cdc.gov)
  • 9. [Spontaneous regression of tumors]. (nih.gov)
  • 12. Spontaneous regression of testicular germ cell tumors: an analysis of 42 cases. (nih.gov)
  • The clinical differential diagnosis of a fibroma depends on its clinical presentation and location and includes giant cell fibroma, neurofibroma , peripheral giant cell granuloma , schwannoma, granular cell tumor, mucocele , and benign and malignant salivary gland tumors (eg, see Salivary Gland Neoplasms ). (medscape.com)
  • They account for 0.03% of new diagnosed neoplasms and for 3% of soft tissue tumors [ 1 ]. (biomedcentral.com)
  • Hemangioma is a neoplasm originating from the endothelial cells (inner surface) of the blood vessels, which accounts for half of all benign tumors in children. (hadassah-hospital.org)
  • A case report of a woman diagnosed with an oral contraceptive-associated liver tumor who experienced spontaneous remission upon cessation of therapy is presented. (nih.gov)
  • The most remarkable clinical features are young age, spontaneous remission of diffuse large cell lymphoma, and severe CNS and skin toxicity of cytotoxic treatment. (nih.gov)
  • 16. Over-expression of TGF-beta1 in Smad4-deficient human oral carcinoma cells causes tumour regression in vivo by mechanisms that sensitize cells to apoptosis. (nih.gov)
  • However, it has also been shown that tumour regression, a microscopic feature associated with necrosis, may be a favourable short term prognostic factor in RCC. (bmj.com)
  • 15. Spontaneous regression of metastases from malignant melanoma: a case report. (nih.gov)
  • 20. [Spontaneous regression in malignant melanoma]. (nih.gov)
  • In daily dermatopathological practice, we are faced with misleading definitions, such as "melanoma in situ with regression," which risk affecting homogeneity for comparison purposes of pathological reports of malignant melanoma. (mdpi.com)
  • The authors conducted a literature review using PubMed and Web of Science (WoS) as the main databases and using the following keywords: "Malignant Melanoma in situ" or "Melanoma in situ" and "regression" and/or "radial growth phase regression. (mdpi.com)
  • 3. Spontaneous neoplastic regression: the significance of apoptosis. (nih.gov)
  • Disappearance of a neoplasm or neoplastic state without the intervention of therapy. (nih.gov)
  • Symptoms and manifestations of the neoplasm depend on which tissues are dominant in the tumor. (hadassah-hospital.org)
  • This neoplasm has the highest rate of spontaneous regression of all cancer types and has been noted to undergo spontaneous and chemically induced differentiation into elements resembling mature nervous tissue. (nih.gov)
  • Most hemangiomas by the age of 9 years undergo spontaneous regression and do not need treatment. (hadassah-hospital.org)
  • Spontaneous resolution of basal cell carcinoma in naevoid basal cell carcinoma syndrome/Gorlin's syndrome. (ox.ac.uk)
  • Increased susceptibility to infection and the possible development of lymphoma and other neoplasms may result from the increase in the degree of immunosuppression in transplant patients. (nih.gov)
  • 13. Spontaneous regression of natural killer cell lymphoma. (nih.gov)
  • Lymphatic malformation or lymphangioma is a rare neoplasm or congenital rest that presents in the head and neck region in more than 70% of cases. (medscape.com)
  • 11. Spontaneous regression of cutaneous head and neck melanoma: implications for the immunologic control of neoplasia. (nih.gov)
  • AKs are widely considered to be premalignant lesions although they have low individual potential for invasive malignancy and higher potential for spontaneous regression. (medscape.com)
  • [ 1 ] In recent years, however, there has been an effort to redefine AKs as malignant neoplasms, because these lesions might essentially represent intraepithelial SCCs in evolution. (medscape.com)
  • The use of computed tomography for follow-up showed the regression, which was confirmed by histological examination. (nih.gov)
  • Eighty patients in whom there was no significant delay between CT imaging and histological diagnosis were assessed by logistic regression analysis to correlate CT and histologic findings. (nih.gov)
  • Using logistic regression analysis, other CT findings did not correlate with histological subtype. (nih.gov)
  • Not all pigment deposits have to be diagnosed, however, as some are almost ubiquitous spontaneous changes in aging animals and/or secondary to extraneous disease processes. (nih.gov)
  • Regression or complete normalisation of the values of certain pathological biohumoral parameters after initial treatment (antibiotic or immunosuppressive) may indicate the benign nature of the disease, but their persistence must raise st frequent) are accompanied by secondary bacterial infections. (md-medicaldata.com)
  • Regression or complete normalisation of the values of certain pathological biohumoral parameters after initial treatment (antibiotic and/or immunosuppressive) indicates the benign nature of a lung disease, while their persistence may suggest malignancy. (md-medicaldata.com)
  • It is a rare disease accounting for 3% of all soft tissue neoplasms, with an incidence of 2-5 people per million per year [ 1 ]. (biomedcentral.com)
  • Is It Time to Supersede the Diagnostic Term "Melanoma In Situ with Regression? (mdpi.com)
  • 2. [Spontaneous regression of cancer--review of cases from 1988 to 2006]. (nih.gov)
  • While the terminology implies a benign neoplasm, most if not all fibromas represent reactive focal fibrous hyperplasia due to trauma or local irritation. (medscape.com)
  • The recommended treatment is surgical excision under local or general anaesthetic, although spontaneous regression has been reported. (hindawi.com)
  • This list is not exhaustive, and there are many additional terms that may be used when indexing neoplasms. (nih.gov)
  • A research for multiple endocrine neoplasm types 1 and 2A was negative. (scirp.org)
  • 8. Spontaneous regression of cancer and the importance of finding its cause. (nih.gov)
  • 18. Regression of cancer following surgery. (nih.gov)
  • Follow-up by CT without therapy (except to stop the oral contraceptives) was sufficient to show spontaneous regression of the lesion. (nih.gov)
  • 4. Spontaneous regression of metastases from melanoma: review of the literature. (nih.gov)
  • In mice, lipofuscin pigment-laden adrenal cortical cells occur most often as late-stage features or sequelae to physiologic regression of the X-zone. (nih.gov)
  • The cortical cell pigment that accumulates as a spontaneous aging change in rats and mice should not be diagnosed unless there are treatment-related differences in incidence or severity. (nih.gov)