A solid, unencapsulated tumor of the KIDNEY composed of spindle mesenchymal cells that resemble FIBROBLASTS or muscle cells. The homogeneous mass typically extends into the renal parenchyma and replaces most of the kidney. In most cases, mesoblastic nephroma is benign and occurs in the fetus or newborn, and rarely in the older child or the adult.
A malignant kidney tumor, caused by the uncontrolled multiplication of renal stem (blastemal), stromal (STROMAL CELLS), and epithelial (EPITHELIAL CELLS) elements. However, not all three are present in every case. Several genes or chromosomal areas have been associated with Wilms tumor which is usually found in childhood as a firm lump in a child's side or ABDOMEN.
A heterogeneous group of hereditary and acquired disorders in which the KIDNEY contains one or more CYSTS unilaterally or bilaterally (KIDNEY, CYSTIC).
Tumors or cancers of the KIDNEY.
Excision of kidney.
A rare but highly lethal childhood tumor found almost exclusively in infants. Histopathologically, it resembles RHABDOMYOSARCOMA but the tumor cells are not of myogenic origin. Although it arises primarily in the kidney, it may be found in other parts of the body. The rhabdoid cytomorphology is believed to be the expression of a very primitive malignant cell. (From Holland et al., Cancer Medicine, 3d ed, p2210)
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Clinical conditions caused by an abnormal sex chromosome constitution (SEX CHROMOSOME ABERRATIONS), in which there is extra or missing sex chromosome material (either a whole chromosome or a chromosome segment).

Prenatal sonographic diagnosis of a fetal renal mesoblastic nephroma occurring after transfer of a cryopreserved embryo. (1/25)

Here we report the first case of prenatally diagnosed fetal renal mesoblastic nephroma occurring after transfer of a cryopreserved embryo. A 37 year old woman, having immunological infertility, was treated by in-vitro fertilization (IVF) and embryo transfer. Following unsuccessful IVF using fresh embryos, the patient conceived after transfer of cryopreserved-thawed embryos. The chromosomal analysis identified a normal karyotype at 16 weeks' gestation when amniocentesis was performed. The pregnancy course was uneventful until 28 weeks' gestation when polyhydramnios associated with fetal renal tumour was detected using ultrasonography. A male infant weighing 2564 g was born via Caesarean section at 34 weeks' gestation. A left nephrectomy was performed 5 days after delivery and the tumour was identified histologically as a mesoblastic nephroma. The postoperative course was uncomplicated to this point.  (+info)

Detection of the ETV6-NTRK3 chimeric RNA of infantile fibrosarcoma/cellular congenital mesoblastic nephroma in paraffin-embedded tissue: application to challenging pediatric renal stromal tumors. (2/25)

We report the development of a reverse transcriptase polymerase chain reaction assay that reliably detects the ETV6-NTRK3 chimeric RNA characteristic of infantile fibrosarcoma and the cellular variant of congenital mesoblastic nephroma (CMN) in formalin-fixed, paraffin-embedded tissue blocks. The 188 base pair polymerase chain reaction fusion product was detected in 11 of 12 cases of cellular CMN from which a larger sized control RNA band could be amplified, and even in 7 of 8 cases in which the control band was not detectable. A variety of other tumors that are in the histologic differential diagnosis of cellular CMN yielded negative results, including four classic CMNs, four rhabdoid tumors of the kidney, and four clear cell sarcomas of the kidney, confirming the assay's specificity. We further demonstrate the assay's utility by illustrating two cases of molecularly confirmed cellular CMN that mimicked rhabdoid tumor and clear cell sarcoma of the kidney. In contrast to previous reports, five mixed CMNs that had both classic and cellular areas all lacked the ETV6-NTRK3 fusion transcript. These results suggest that cases morphologically defined as mixed CMN may represent a mixed group of genetically distinct entities.  (+info)

Diagnosis of a fetal mesoblastic nephroma by 3D-ultrasound. (3/25)

We report a case of a fetal renal tumor detected prenatally on 3D-ultrasound. As the lesion was well encapsulated the initial sonographic diagnosis was that of a nephroblastoma. Volume calculation by the 3D technique gave a reliable estimation of the tumor size. Contrary to all published case reports concerning antenatally diagnosed mesoblastic nephromas, there was no polyhydramnios. Elective delivery was performed by Cesarean section at 38+ weeks gestation. The neonate underwent left nephrectomy on the second day of life. The subsequent course was uneventful without recurrence of the tumor.  (+info)

ETV6 rearrangements in patients with infantile fibrosarcomas and congenital mesoblastic nephromas by fluorescence in situ hybridization. (4/25)

Congenital mesoblastic nephroma (CMN) and infantile fibrosarcoma (IFS) are two pediatric tumors arising in the kidneys and soft tissues of infants, respectively. Recently, a t(12;15)(p13;q25) resulting in ETV6-NTRK3 gene fusion was detected in patients with IFS and in patients with the cellular type of CMN, suggesting a common pathogenetic pathway. We investigated the presence or absence of ETV6 rearrangements and numerical abnormalities of chromosome 11 by using fluorescence in situ hybridization on paraffin-embedded material from five cases of IFS, two of CMN, and one of mixed type (CMN and IFS) found in our files. In three cases of IFS, we found ETV6 gene rearrangement but a normal copy number of chromosome 11. One case each of IFS, the cellular type of CMN, and the mixed type (CMN and IFS) had both abnormalities. In a case of classic CMN, neither trisomy 11 nor gene rearrangement was found. It is possible that trisomy 11 is a later, nonessential event in the pathogenetic process or that this secondary aberration is associated with still-unrecognized clinical or biological characteristics. We confirmed that IFS and the cellular type of CMN are cytogenetically related and can occur synchronously in the same organ.  (+info)

Prenatal detection of mesoblastic nephroma by sonography and magnetic resonance imaging. (5/25)

Congenital mesoblastic nephroma is the most common neonatal kidney tumor and surgical excision is almost always curative. We report the prenatal detection of congenital mesoblastic nephroma by sonography and magnetic resonance imaging. After birth, a right nephrectomy was performed and the baby recovered well.  (+info)

KIT expression in fetal, normal adult, and neoplastic renal tissues. (6/25)

BACKGROUND: KIT is a transmembrane tyrosine kinase receptor, expressed in high amounts in various normal cells. In addition, c-kit mutation or activation is a major pathogenetic event in certain tumours (such as gastrointestinal stromal tumours). There are only limited data in the literature on the expression of KIT in normal and neoplastic renal tissues. AIMS: To investigate KIT expression in normal and neoplastic renal tissues. METHODS: KIT expression was evaluated by means of immunohistochemistry in paraffin wax embedded sections from 67 tissue samples. RESULTS: Eight of eight fetal kidneys, and 10 of 10 normal adult kidneys revealed cytoplasmic staining of renal tubules. The three cases of renal dysplasia studied expressed KIT in their normal and aberrant tubules. Two of 13 conventional renal cell carcinomas (RCCs), two of seven papillary type RCCs, four of seven chromophobe type RCCs, none of six nephroblastomas, seven of seven oncocytomas, two of two mesoblastic nephromas, and two of four angiomyolipomas were positive. CONCLUSION: KIT is expressed in normal fetal and adult renal tubules, and in a subset of renal tumours. The expression of KIT in these renal tumours may prove to have diagnostic relevance and/or therapeutic implications.  (+info)

Mesoblastic nephroma--a report from the Gesellschaft fur Padiatrische Onkologie und Hamatologie (GPOH). (7/25)

BACKGROUND: Surgery alone is the appropriate first-line treatment for patients with mesoblastic nephroma (MN). Nevertheless, there are reports of local recurrences and metastasis, especially in the cellular subtype. The authors evaluated the outcome of patients with MN who were enrolled in either the International Society of Pediatric Oncology (SIOP) 93-01/GPOH or the SIOP 2001/GPOH Nephroblastoma Study and Trial. METHODS: In total, 50 patients with MN were analyzed. Eleven patients were suspected antenatally of having a renal tumor. The median age at diagnosis was 18.5 days. Central pathologic review was performed for all specimens. The median observation time was 4.2 years. RESULTS: Forty-five patients underwent initial surgery. Five patients older than 6 months received preoperative chemotherapy. Twenty-nine tumors were classic MN, and 21 tumors were cellular MN. Nine patients had a Stage III MN, 5 of those patients had tumor ruptures, and 8 had positive surgical margins. After they underwent nephrectomy, 40 patients received no further treatment. For the entire group, event-free survival (EFS) (94%) and overall survival (OS) (95%) were excellent. Patients with a cellular MN, patients with age 3 months or older, and patients with Stage III MN had lower EFS. Three patients developed recurrent disease, and 2 of those patients died. Metastases to the brain, lung, and liver were observed in 1 patient. CONCLUSIONS: Radical nephrectomy with accurate surgical-pathologic staging is the standard of care for children with MN. Nonetheless, a subgroup of patients with MN (Stage III cellular MN in patients age 3 months or older) tends to develop recurrences more often. Further prospective studies will be needed to verify this finding and should help determine whether these patients may benefit from adjuvant therapy.  (+info)

Benign mixed epithelial and stromal tumor of the kidney. (8/25)

A 51-year-old, perimenopausal, female patient with 1-month history of right flank pain who was diagnosed with a renal mass and underwent nephron-sparing partial nephrectomy is presented. The renal mass was found to be a benign, biphasic tumor composed of an epithelial component, consisting of ducts of variable size scattered within a mesenchymal component, composed of spindle cells arranged in sheets and fascicles. No atypia, mitosis, or necrosis was found. The spindle component shows desmin, smooth muscle actin, and estrogen and progesterone receptor positivity immunohistochemically. The diagnosis of benign mixed epithelial and stromal tumor of the kidney is rendered. No recurrent disease has been detected during 2 years of follow up.  (+info)

Mesoblastic Nephroma is a rare type of kidney tumor that typically occurs in infants and young children. It is usually diagnosed within the first year of life, with most cases occurring in the first three months.

The term "mesoblastic" refers to the origin of the tumor cells, which are thought to arise from the mesenchymal tissue, a type of connective tissue that gives rise to various structures during embryonic development.

Mesoblastic Nephroma is classified into two types: classic and cellular. The classic type is composed of fascicles of spindle-shaped cells with interspersed mature adipose tissue, while the cellular type is made up of sheets of closely packed cells that resemble embryonal rhabdomyosarcoma.

The tumor can be asymptomatic or may present with abdominal distension, palpable mass, hematuria, or hypertension. The diagnosis is usually made by imaging studies such as ultrasound, CT scan, or MRI, followed by a biopsy to confirm the histological type.

Treatment typically involves surgical resection of the tumor, and the prognosis is generally excellent, with a high cure rate. However, close follow-up is necessary to monitor for any signs of recurrence or metastasis.

Wilms tumor, also known as nephroblastoma, is a type of kidney cancer that primarily affects children. It occurs in the cells of the developing kidneys and is named after Dr. Max Wilms, who first described this type of tumor in 1899. Wilms tumor typically develops before the age of 5, with most cases occurring in children under the age of 3.

The medical definition of Wilms tumor is:

A malignant, embryonal kidney tumor originating from the metanephric blastema, which is a mass of undifferentiated cells in the developing kidney. Wilms tumor is characterized by its rapid growth and potential for spread (metastasis) to other parts of the body, particularly the lungs and liver. The tumor usually presents as a large, firm, and irregular mass in the abdomen, and it may be associated with various symptoms such as abdominal pain, swelling, or blood in the urine.

Wilms tumor is typically treated with a combination of surgery, chemotherapy, and radiation therapy. The prognosis for children with Wilms tumor has improved significantly over the past few decades due to advances in treatment methods and early detection.

Cystic kidney diseases are a group of genetic disorders that cause fluid-filled sacs called cysts to form in the kidneys. These cysts can vary in size and can grow over time, which can lead to damage in the kidneys and affect their function. There are two main types of cystic kidney diseases: autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD).

ADPKD is the most common type and is characterized by the presence of numerous cysts in both kidneys. It is usually diagnosed in adulthood, but it can also occur in children. The cysts can cause high blood pressure, kidney stones, urinary tract infections, and eventually kidney failure.

ARPKD is a rare, inherited disorder that affects both the kidneys and liver. It is characterized by the presence of numerous cysts in the kidneys and abnormalities in the bile ducts of the liver. ARPKD is usually diagnosed in infancy or early childhood and can cause serious complications such as respiratory distress, kidney failure, and liver fibrosis.

Other types of cystic kidney diseases include nephronophthisis, medullary cystic kidney disease, and glomerulocystic kidney disease. These conditions are also inherited and can cause kidney damage and kidney failure.

Treatment for cystic kidney diseases typically involves managing symptoms such as high blood pressure, pain, and infections. In some cases, surgery may be necessary to remove large cysts or to treat complications such as kidney stones. For individuals with advanced kidney disease, dialysis or a kidney transplant may be necessary.

Kidney neoplasms refer to abnormal growths or tumors in the kidney tissues that can be benign (non-cancerous) or malignant (cancerous). These growths can originate from various types of kidney cells, including the renal tubules, glomeruli, and the renal pelvis.

Malignant kidney neoplasms are also known as kidney cancers, with renal cell carcinoma being the most common type. Benign kidney neoplasms include renal adenomas, oncocytomas, and angiomyolipomas. While benign neoplasms are generally not life-threatening, they can still cause problems if they grow large enough to compromise kidney function or if they undergo malignant transformation.

Early detection and appropriate management of kidney neoplasms are crucial for improving patient outcomes and overall prognosis. Regular medical check-ups, imaging studies, and urinalysis can help in the early identification of these growths, allowing for timely intervention and treatment.

Nephrectomy is a surgical procedure in which all or part of a kidney is removed. It may be performed due to various reasons such as severe kidney damage, kidney cancer, or living donor transplantation. The type of nephrectomy depends on the reason for the surgery - a simple nephrectomy involves removing only the affected portion of the kidney, while a radical nephrectomy includes removal of the whole kidney along with its surrounding tissues like the adrenal gland and lymph nodes.

A rhabdoid tumor is a rare and aggressive type of cancer that typically develops in the kidneys of children, but can also occur in other areas of the body such as the brain, soft tissues, and lungs. These tumors are characterized by the presence of cells with a unique appearance, known as rhabdoid cells, which have large nuclei, prominent nucleoli, and eosinophilic inclusions.

Rhabdoid tumors can occur in both children and adults, but they are most commonly found in children under the age of 3. They are often resistant to conventional cancer treatments such as chemotherapy and radiation therapy, making them difficult to treat. The prognosis for patients with rhabdoid tumors is generally poor, with a high rate of recurrence and metastasis.

The exact cause of rhabdoid tumors is not known, but they are associated with mutations in the SMARCB1 or SMARCA4 genes, which are involved in regulating gene expression and maintaining genomic stability. These genetic changes can occur spontaneously or may be inherited from a parent.

Treatment for rhabdoid tumors typically involves a combination of surgery, chemotherapy, and radiation therapy. In some cases, stem cell transplantation or targeted therapies may also be used. Despite aggressive treatment, the prognosis for patients with rhabdoid tumors remains poor, with a five-year survival rate of less than 20%.

An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.

Sex chromosome disorders are genetic conditions that occur due to an atypical number or structure of the sex chromosomes, which are X and Y. Normally, females have two X chromosomes (XX), and males have one X and one Y chromosome (XY). However, in sex chromosome disorders, there is a variation in the number or composition of these chromosomes.

The most common sex chromosome disorders include:

1. Turner syndrome (Monosomy X): Occurs when a female has only one X chromosome (45,X). This condition affects about 1 in every 2,500 female births and can lead to short stature, infertility, heart defects, and learning disabilities.
2. Klinefelter syndrome (XXY): Occurs when a male has an extra X chromosome (47,XXY). This condition affects about 1 in every 500-1,000 male births and can lead to tall stature, infertility, breast development, and learning disabilities.
3. Jacobs syndrome (XYY): Occurs when a male has an extra Y chromosome (47,XYY). This condition affects about 1 in every 1,000 male births and can lead to tall stature, learning disabilities, and behavioral issues.
4. Triple X syndrome (XXX): Occurs when a female has an extra X chromosome (47,XXX). This condition affects about 1 in every 1,000 female births and can lead to mild developmental delays and learning disabilities.
5. Other rare sex chromosome disorders: These include conditions like 48,XXXX, 49,XXXXY, and mosaicism (a mixture of cells with different chromosome compositions).

Sex chromosome disorders can have varying degrees of impact on an individual's physical and cognitive development. While some individuals may experience significant challenges, others may have only mild or no symptoms at all. Early diagnosis and appropriate interventions can help improve outcomes for those affected by sex chromosome disorders.

The contribution of these trisomies to the development of mesoblastic nephroma is unclear. Diagnosis of mesoblastic nephroma ... within this tumor are the same as those found in cellular mesoblastic nephroma. Mesoblastic nephroma and congenital infantile ... Congenital mesoblastic nephroma, while rare, is the most common kidney neoplasm diagnosed in the first three months of life and ... Congenital mesoblastic nephroma was first named as such in 1967 but was recognized decades before this as fetal renal hamartoma ...
Mesoblastic nephroma, although rare, also typically presents in childhood. Renal cell carcinoma has been further divided into ...
Additional radiological features include hyperplastic nephromegaly, dysplastic medulla, and mesoblastic nephroma. Only three ...
... and mesoblastic nephroma. Wilms tumor, hepatoblastoma, and mesoblastic nephroma can usually be cured if diagnosed early. Early ... "Congenital mesoblastic nephroma 50 years after its recognition: A narrative review" (PDF). Pediatric Blood & Cancer. 64 (7): ...
... within this tumor are similar to those found in the cellular form of mesoblastic nephroma. Indeed, mesoblastic nephroma and ... Wang ZP, Li K, Dong KR, Xiao XM, Zheng S (2014). "Congenital mesoblastic nephroma: Clinical analysis of eight cases and a ... "Congenital mesoblastic nephroma: a study of 19 cases using immunohistochemistry and ETV6-NTRK3 fusion gene rearrangement". ... congenital infantile sarcoma appear to be the same disease with the exception that mesoblastic lymphoma originates in the ...
... cystic mesoblastic nephroma cystic renal cell carcinoma other renal cysts Micrograph of a cystic nephroma. H&E stain. Turbiner ... A cystic nephroma, also known as multilocular cystic nephroma, mixed epithelial stromal tumour (MEST) and renal epithelial ... Small JE, Jinnteh T, Hong X, Tuncali K, Seltzer SE, Ros PR (11 August 2003). "Cystic Nephroma". BrighamRAD Teaching Case ... J, Amin MB, Humphrey PA, Srigley JR, De Leval L, Radhakrishnan A, Oliva E (April 2007). "Cystic nephroma and mixed epithelial ...
... congenital mesoblastic nephroma, inflammatory myofibroblastic tumor, and radiation-induced papillary thyroid carcinoma. The ... "Detection of the ETV6-NTRK3 chimeric RNA of infantile fibrosarcoma/cellular congenital mesoblastic nephroma in paraffin- ...
Collecting duct RCC Mesoblastic nephroma, a congenital tumor of the kidney's mesenchyme (i.e. connective tissue cells) detected ...
... congenital mesoblastic nephroma, rare cases of acute myelogenous leukemia, ALK-negative Inflammatory myofibroblastic tumour, ... "Detection of the ETV6-NTRK3 chimeric RNA of infantile fibrosarcoma/cellular congenital mesoblastic nephroma in paraffin- ...
Congenital s Congenital megacolon Congenital megaloureter Congenital mesoblastic nephroma Congenital microvillous atrophy ...
... nephroma, mesoblastic MeSH C04.557.435.675 - pulmonary blastoma MeSH C04.557.435.710 - rhabdoid tumor MeSH C04.557.435.775 - ... nephroma, mesoblastic MeSH C04.588.945.947.940 - ureteral neoplasms MeSH C04.588.945.947.945 - urethral neoplasms MeSH C04.588. ...
... nephroma, mesoblastic MeSH C13.371.820.800.820.875 - ureteral neoplasms MeSH C13.371.820.800.820.890 - urethral neoplasms MeSH ...
... the cellular variant of congenital mesoblastic nephroma, and radiation-induced papillary thyroid carcinoma), these tumors' ...
... nephroma, mesoblastic MeSH C12.740.800.820.875 - ureteral neoplasms MeSH C12.740.800.820.937 - urethral neoplasms MeSH C12.777. ... nephroma, mesoblastic MeSH C12.777.419.493 - kidney papillary necrosis MeSH C12.777.419.570 - nephritis MeSH C12.777.419.570. ...
This mutant fusion gene also occurs in congenital fibrosarcoma, congenital mesoblastic nephroma, secretory breast cancer (also ...
... nephroblastoma M8959/3 Malignant cystic nephroma Malignant multilocular cystic nephroma M8960/1 Mesoblastic nephroma M8960/3 ... Carcinoma in pleomorphic adenoma M8950/3 Mullerian mixed tumor M8951/3 Mesodermal mixed tumor M8959/0 Benign cystic nephroma ... Nephroblastoma, NOS Wilms's tumor Nephroma, NOS M8963/3 malignant rhabdoid tumor Rhabdoid sarcoma Rhabdoid tumor, NOS M8964/3 ...
The contribution of these trisomies to the development of mesoblastic nephroma is unclear. Diagnosis of mesoblastic nephroma ... within this tumor are the same as those found in cellular mesoblastic nephroma. Mesoblastic nephroma and congenital infantile ... Congenital mesoblastic nephroma, while rare, is the most common kidney neoplasm diagnosed in the first three months of life and ... Congenital mesoblastic nephroma was first named as such in 1967 but was recognized decades before this as fetal renal hamartoma ...
Mesoblastic nephroma is the most common renal tumor identified in the neonatal period and the most frequent benign renal tumor ... encoded search term (Mesoblastic Nephroma Imaging) and Mesoblastic Nephroma Imaging What to Read Next on Medscape ... Mesoblastic Nephroma Imaging Updated: Jun 27, 2019 * Author: Sudha Pradumna Singh, MBBS, MD; Chief Editor: Eugene C Lin, MD ... Mesoblastic nephroma (also called fetal renal hamartoma) is the most common renal tumor identified in the neonatal period and ...
Mesoblastic nephroma is the most common renal tumor identified in the neonatal period and the most frequent benign renal tumor ... encoded search term (Mesoblastic Nephroma Imaging) and Mesoblastic Nephroma Imaging What to Read Next on Medscape ... Mesoblastic Nephroma Imaging. Updated: Oct 04, 2015 * Author: Sudha Pradumna Singh, MBBS, MD; Chief Editor: Eugene C Lin, MD ... Mesoblastic nephroma is the most common renal tumor in neonates and infants and represents 3% of the pediatric renal tumors. [4 ...
Congenital mesoblastic nephroma: An immunohistochemical and lectin study. Tibor Nadasdy, Jürgen Roth, Debbie L. Johnson, ... Dive into the research topics of Congenital mesoblastic nephroma: An immunohistochemical and lectin study. Together they form ...
Sonograms show mesoblastic nephroma as a complex mass that may contain cystic areas. A Wilms tumor may also appear as a ... How is mesoblastic nephroma differentiated from Wilms tumor on imaging?. How is clear cell sarcoma differentiated from Wilms ... Mesoblastic nephroma is the most common congenital renal neoplasm. It is a solitary hamartoma, and it is usually benign and ... On sonograms, mesoblastic nephroma is seen as a large, solitary, predominantly solid, coarse, and echogenic renal mass that may ...
Sonograms show mesoblastic nephroma as a complex mass that may contain cystic areas. A Wilms tumor may also appear as a ... How is mesoblastic nephroma differentiated from Wilms tumor on imaging?. How is clear cell sarcoma differentiated from Wilms ... Mesoblastic nephroma is the most common congenital renal neoplasm. It is a solitary hamartoma, and it is usually benign and ... On sonograms, mesoblastic nephroma is seen as a large, solitary, predominantly solid, coarse, and echogenic renal mass that may ...
Congenital mesoblastic nephroma. Wootton SL, Rowen SJ, Griscom NT. Wootton SL, et al. Radiographics. 1991 Jul;11(4):719-21. doi ...
Mesoblastic Nephroma. Neuroblastoma. Sacrococcygeal teratoma. Tumors - Hepatic. Tumors-CNS. Urinary. - Reviews & Chapters - ...
Mesoblastic Nephroma. Neuroblastoma. Sacrococcygeal teratoma. Tumors - Hepatic. Tumors-CNS. Urinary. - Reviews & Chapters - ...
The only variant culture was derived from mesoblastic nephroma, a distinct childhood kidney neoplasm. Retinoid/HDAC inhibitor ...
... mesoblastic nephroma, others; Pediatric bone and soft tissue tumors- rhabdomyosarcoma, osteosarcoma, others; Germ cell tumors- ...
... other tumors that might be present include mesoblastic nephroma (typically in infants), clear cell sarcoma, rhabdoid tumor, and ...
... including secretary breast carcinoma and cellular or mixed congenital mesoblastic nephroma.. NTRK fusions in cancer were ...
... identified in a range of mesenchymal tumours unrelated to infantile fibrosarcoma or cellular congenital mesoblastic nephroma, ... identified in a range of mesenchymal tumours unrelated to infantile fibrosarcoma or cellular congenital mesoblastic nephroma, ... identified in a range of mesenchymal tumours unrelated to infantile fibrosarcoma or cellular congenital mesoblastic nephroma, ... identified in a range of mesenchymal tumours unrelated to infantile fibrosarcoma or cellular congenital mesoblastic nephroma, ...
O Congenital mesoblastic nephroma,O Congenital microcephaly,O Congenital microthorax,O Congenital miosis,O Congenital mitral ...
congenital mesoblastic nephroma + congenital mirror movement disorder + congenital muscular dystrophy + congenital myasthenic ...
Congenital Mesoblastic Nephroma, Desmoid Fibromatosis, Lymphoproliferative Disorder, Malignant Solid Neoplasm, ...
Other tumors such as rhabdoid tumors of the kidney, clear cell sarcoma of the kidney and mesoblastic nephroma occur in the ...
Keywords:Congenital mesoblastic nephroma (CMN); cellular CMN; case report; prenatal MRI; ETV6;. ... Cellular congenital mesoblastic nephroma detected by prenatal MRI: a case report and literature review. TRANSLATIONAL ...
Tumour types known to frequently harbour NTRK gene fusions (i.e., infantile fibrosarcoma, congenital mesoblastic nephroma, ...
Pamidronate therapy for hypercalcemia and congenital mesoblastic nephroma: a case report Hypercalcemia can causes life ... We report an infant with severe hypercalcemia due to congenital mesoblastic nephroma. Hypercalcemia was corrected before ...
... of the paternal IGF2 allele in trisomy 11 and elevated expression levels of IGF2 mRNA in congenital mesoblastic nephroma of the ...
Mesoblastic Nephroma. -. 94.93. 7 of 7. PDGFRA. Gastrointestinal Stromal Tumor/Gist-. Plus Syndrome,. Hypereosinophilic. ...
classic congenital mesoblastic nephroma DOID:8083 * childhood kidney cell carcinoma DOID:4454 ...
mesoblastic nephroma*most common neonatal renal mass; benign hamartoma but is nonetheless resected as sarcomatous degeneration ...
mesoblastic nephroma DOID:4772 * childhood choriocarcinoma of the ovary DOID:8336 * mature gastric teratoma ...
mesoblastic nephroma;. *angiomyolipoma.. Symptoms arent usually detected at the initial stages of kidney cancer. In the later ...
Underlining a close relationship with congenital mesoblastic nephroma and highlighting a similar morphological spectrum. van ...
Congenital mesoblastic nephroma makes up less than 3% of renal neoplasms in children; it is the predominant renal neoplasm in ... FIGURE 30.4 Congenital mesoblastic nephroma. The tumor is composed of bland, spindle-shaped cells growing in an infiltrative ... Congenital mesoblastic nephroma was first recognized in 1966 (25), and subsequent studies have shown it to be a morphologically ... Congenital mesoblastic nephroma is usually large relative to the infants kidney. The external surfaces of the tumor and kidney ...
Lilly, J. V., Rokita, J. L., Mason, J. L., Patton, T., Stefankiewiz, S., Higgins, D., Trooskin, G., Larouci, C. A., Arya, K., Appert, E., Heath, A. P., Zhu, Y., Brown, M. A., Zhang, B., Farrow, B. K., Robins, S., Morgan, A. M., Nguyen, T. Q., Frenkel, E., Lehmann, K., & 80 othersDrake, E., Sullivan, C., Plisiewicz, A., Coleman, N., Patterson, L., Koptyra, M., Helili, Z., Van Kuren, N., Young, N., Kim, M. C., Friedman, C., Lubneuski, A., Blackden, C., Williams, M., Baubet, V., Tauhid, L., Galanaugh, J., Boucher, K., Ijaz, H., Cole, K. A., Choudhari, N., Santi, M., Moulder, R. W., Waller, J., Rife, W., Diskin, S. J., Mateos, M., Parsons, D. W., Pollack, I. F., Goldman, S., Leary, S., Caporalini, C., Buccoliero, A. M., Scagnet, M., Haussler, D., Hanson, D., Firestein, R., Cain, J., Phillips, J. J., Gupta, N., Mueller, S., Grant, G., Monje-Deisseroth, M., Partap, S., Greenfield, J. P., Hashizume, R., Smith, A., Zhu, S., Johnston, J. M., Fangusaro, J. R., Miller, M., Wood, M. D., Gardner, S., Carter, ...
  • Although Wilms Tumor is by far the most common solid tumor that develops in the kidney in pediatric patients, other tumors that might be present include mesoblastic nephroma (typically in infants), clear cell sarcoma, rhabdoid tumor, and renal cell carcinoma (in adolescents, though more common in adults). (hopkinsmedicine.org)
  • Other tumors such as rhabdoid tumors of the kidney, clear cell sarcoma of the kidney and mesoblastic nephroma occur in the kidney but are not Wilms tumors and have different prognoses and treatment. (luriechildrens.org)
  • The classic and the cellular variants of mesoblastic nephroma differ in the age at presentation, histologic characteristics, imaging characteristics and the biologic behavior of the tumors. (medscape.com)
  • Mesoblastic nephroma is the most common renal tumor in neonates and infants and represents 3% of the pediatric renal tumors. (medscape.com)
  • Mesoblastic nephroma is the most common renal tumor presenting in the neonatal period and accounts for approximately 54% of tumors in this age group. (medscape.com)
  • Classical congenital mesoblastic nephroma represents approximately 20% of all congenital mesoblastic nephromas and these tumors are morphologically similar to infantile fibromatosis. (cap.org)
  • Another 20% of cases include mixed-type congenital mesoblastic nephroma, those tumors containing histologic features of both cellular and classical congenital mesoblastic nephroma. (cap.org)
  • Mesoblastic nephroma (also called fetal renal hamartoma) is the most common renal tumor identified in the neonatal period and the most frequent benign renal tumor in childhood. (medscape.com)
  • Patients with congenital mesoblastic nephroma almost always have an excellent prognosis when the tumor has been completely excised. (cap.org)
  • Gross pathologic findings of congenital mesoblastic nephroma typically include tumor, which may measure up to or greater than 10.0 cm. (cap.org)
  • Congenital mesoblastic nephroma represents approximately 2-4% of all pediatric renal neoplasms. (cap.org)
  • TRK fusions are very common in some rare pediatric cancers, in particular infantile fibrosarcoma and congenital mesoblastic nephroma, and had been described across a range of other pediatric cancers," Dr Laetsch added. (cancertherapyadvisor.com)
  • While the TRK fusions befall in exclusively a cheap proportion of inferior grown-up cancers, they turn up frequently in some rare pediatric cancers, such as babyish fibrosarcoma, cellular congenital mesoblastic nephroma, and papillary thyroid cancer, asserted Dr. Laetsch, who contrast c embarrass the ways the Tentative Restoratives Program (ETP) in the Pauline Allen Gill Center for Cancer and Blood Hubbubs at Children's Haleness in Dallas. (piwip.com)
  • Oncogenic fusions involving neurotrophic receptor tyrosine kinase (NTRK) genes are being increasingly identified in a range of mesenchymal tumours unrelated to infantile fibrosarcoma or cellular congenital mesoblastic nephroma, where the canonical ETV6-NTRK3 fusion was first described more than two decades ago. (edu.au)
  • Cellular mesoblastic nephroma is characterized by recurring cytogenetic abnormalities similar to that identified within infantile fibrosarcoma. (cap.org)
  • Congenital mesoblastic nephroma, while rare, is the most common kidney neoplasm diagnosed in the first three months of life and accounts for 3-5% of all childhood renal neoplasms. (wikipedia.org)
  • The only variant culture was derived from mesoblastic nephroma, a distinct childhood kidney neoplasm. (uni-wuerzburg.de)
  • The translocation of 12 and 15 identified within congenital mesoblastic nephromas of the cellular subtype include an ETV6-NTRK3 fusion gene. (cap.org)
  • A high frequency of gene fusions have been identified in mammary analogue secretory carcinomas (90%C100%)11 and secretory breast carcinomas ( 90%)12 in adult patients, and in infantile fibrosarcomas (91%C100%),34 other mesenchymal tumours (100%)41 and congenital mesoblastic nephromas (83%)42 in paediatric patients. (researchtoactionforum.org)
  • Based on a limited number of genetic studies (a total of 65 patients), the ETY6-NTRK3 fusion gene appears to occur in most cases of the cellular and some cases of the mixed but no cases of the classical types of congenital mesolastic nephroma. (wikipedia.org)
  • However, a more recent study of 19 patients detected the fused gene in all 8 cases of cellular, 5 of 6 cases of mixed, and 0 of 5 cases of classic mesoblastic nephroma. (wikipedia.org)
  • Diagnosis of mesoblastic nephroma and its particular type (i.e. classic, mixed, or cellular) is made by histological examination of tissues obtained at surgery. (wikipedia.org)
  • NTRK fusions appear in some common cancers, such as non-small cell lung, sarcoma and colon, as well as some rare cancers, including secretary breast carcinoma and cellular or mixed congenital mesoblastic nephroma. (curetoday.com)
  • Histologically, two types of congenital mesoblastic nephroma are recognized, the cellular type and the classical type. (cap.org)
  • Cellular mesoblastic nephromas account for approximately 60% of all congenital mesoblastic nephroma cases. (cap.org)
  • Congenital mesoblastic nephroma was first named as such in 1967 but was recognized decades before this as fetal renal hamartoma or leiomyomatous renal hamartoma. (wikipedia.org)
  • The diagnosis of mesoblastic nephroma may be made antenatally on ultrasound. (medscape.com)
  • After surgery the doctors were able to give us a preliminary diagnosis - mesoblastic nephroma - a very rare type of kidney tumour. (lecoco.com.au)
  • Congenital Mesoblastic nephroma is a malignant tumorous growth of the kidney's mesenchyme (i.e. connective tissue cells). (wikipedia.org)
  • A study conducted in 1998 found that congenital mesoblastic nephroma tissues taken from some patients contained an acquired mutation, the ETV6-NTRK3 fusion gene. (wikipedia.org)
  • Congenital mesoblastic nephroma typically (76% of cases) presents as an abdominal mass which is detected prenatally (16% of cases) by ultrasound or by clinical inspection (84% of cases) either at birth or by 3.8 years of age (median age ~1 month). (wikipedia.org)
  • Congenital mesoblastic nephroma is typically negative for BCL2, CD34 and pancytokeratin. (cap.org)
  • This examination divides congenital mesoblastic nephroma into three types: 1) The classic type occurs in ~39% of patients. (wikipedia.org)
  • Chaque année, des milliers de volontaires, pour la plupart des patients, mais aussi des personnes en bonne santé, participent à nos études. (ottawaheart.ca)
  • The clinicopathologic findings in this patient's case support a congenital mesoblastic nephroma, classical type. (cap.org)
  • This suggests that expression of this fused gene may be more common in cellar and mixed mesoblastic nephroma than previously appreciated. (wikipedia.org)
  • This case first appeared as Performance Improvement Program in Surgical Pathology (PIP) 2013, case 23, and is a congenital mesoblastic nephroma. (cap.org)
  • At six months old, Matteo was diagnosed with congenital mesoblastic nephroma. (roselleparknews.org)
  • Congenital mesoblastic nephroma, while rare, is the most common kidney neoplasm diagnosed in the first three months of life and accounts for 3-5% of all childhood renal neoplasms. (wikipedia.org)
  • Congenital mesoblastic nephroma was first named as such in 1967 but was recognized decades before this as fetal renal hamartoma or leiomyomatous renal hamartoma. (wikipedia.org)
  • Congenital mesoblastic nephroma typically (76% of cases) presents as an abdominal mass which is detected prenatally (16% of cases) by ultrasound or by clinical inspection (84% of cases) either at birth or by 3.8 years of age (median age ~1 month). (wikipedia.org)
  • Congenital Mesoblastic nephroma is a malignant tumorous growth of the kidney's mesenchyme (i.e. connective tissue cells). (wikipedia.org)
  • This examination divides congenital mesoblastic nephroma into three types: 1) The classic type occurs in ~39% of patients. (wikipedia.org)
  • A study conducted in 1998 found that congenital mesoblastic nephroma tissues taken from some patients contained an acquired mutation, the ETV6-NTRK3 fusion gene. (wikipedia.org)
  • Based on a limited number of genetic studies (a total of 65 patients), the ETY6-NTRK3 fusion gene appears to occur in most cases of the cellular and some cases of the mixed but no cases of the classical types of congenital mesolastic nephroma. (wikipedia.org)
  • Congenital mesoblastic nephroma is a rare type of kidney tumor that occurs in infants and young children. (rarediseaseshealthcenter.com)
  • What are the symptoms of Congenital mesoblastic nephroma? (rarediseaseshealthcenter.com)
  • The most common symptom of congenital mesoblastic nephroma is a large abdominal mass. (rarediseaseshealthcenter.com)
  • What are the causes of Congenital mesoblastic nephroma? (rarediseaseshealthcenter.com)
  • What are the treatments for Congenital mesoblastic nephroma? (rarediseaseshealthcenter.com)
  • The main treatment for congenital mesoblastic nephroma is surgery. (rarediseaseshealthcenter.com)
  • Congenital mesoblastic nephroma is a rare type of kidney cancer that typically affects infants and young children. (rarediseaseshealthcenter.com)
  • Genetic predisposition: Certain genetic mutations may increase the risk of developing congenital mesoblastic nephroma. (rarediseaseshealthcenter.com)
  • Family history: Having a family history of kidney cancer may increase the risk of developing congenital mesoblastic nephroma. (rarediseaseshealthcenter.com)
  • Is there a cure/medications for Congenital mesoblastic nephroma? (rarediseaseshealthcenter.com)
  • One of these soft tissue cancers, known as congenital mesoblastic nephroma (CMN), is the most common kidney tumour diagnosed in early infancy. (sciencedaily.com)
  • Dramatic bone remodeling following larotrectinib administration for bone metastasis in a patient with TRK fusion congenital mesoblastic nephroma. (stjude.org)
  • These changes may lead to non-cancerous (benign) tumours such as congenital mesoblastic nephroma, which develops in very young children. (cancer.ca)
  • Mixed type, congenital mesoblastic nephroma. (familytreecounseling.com)
  • This specific translocation is associated with congenital fibrosarcoma and mesoblastic nephroma, two morphologically similar pediatric mesenchymal tumors with no epithelial features [ 14 ]. (biomedcentral.com)
  • 90%) in certain tumors such as infantile fibrosarcoma, congenital mesoblastic nephroma, and secretory carcinoma, but lower (5%-26%) in PTCs. (cancertherapyadvisor.com)
  • Rare renal malignancies in the pediatric population include renal medullary carcinoma, malignant rhabdoid tumor, clear cell sarcoma of the kidney, Ewing's sarcoma of the kidney, and the cellular variant of congenital mesoblastic nephroma (i.e., infantile fibrosarcoma), among others. (psorc.org)
  • 1. Multilocular cystic nephroma simulating Wilms' tumour. (nih.gov)
  • The medical team believed it was likely to be a mesoblastic nephroma or Wills Tumour and surgery was booked for the following week. (run2cure.org.au)
  • Mesoblastic nephroma (also called fetal renal hamartoma) is the most common renal tumor identified in the neonatal period and the most frequent benign renal tumor in childhood. (medscape.com)
  • In most cases, mesoblastic nephroma is benign and occurs in the fetus or newborn, and rarely in the older child or the adult. (ouhsc.edu)
  • 4. [Benign multilocular cystic nephroma]. (nih.gov)
  • Case report: Multimodality imaging of a cystic nephroma. (ouhsc.edu)
  • 2. Multilocular cystic nephroma: report of three cases. (nih.gov)
  • 3. Multilocular cystic nephroma. (nih.gov)
  • 5. [A case report of multilocular cystic nephroma]. (nih.gov)
  • 8. [Multilocular cystic nephroma]. (nih.gov)
  • 16. [A case of multilocular cystic nephroma]. (nih.gov)
  • 18. [The multilocular cystic nephroma in childhood. (nih.gov)
  • 20. [Multilocular cystic nephroma in children. (nih.gov)
  • The radiologic characteristics of mesoblastic nephroma are demonstrated in the images below. (medscape.com)
  • Nephroma, Mesoblastic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
  • However, a more recent study of 19 patients detected the fused gene in all 8 cases of cellular, 5 of 6 cases of mixed, and 0 of 5 cases of classic mesoblastic nephroma. (wikipedia.org)
  • This suggests that expression of this fused gene may be more common in cellar and mixed mesoblastic nephroma than previously appreciated. (wikipedia.org)
  • This graph shows the total number of publications written about "Nephroma, Mesoblastic" by people in this website by year, and whether "Nephroma, Mesoblastic" was a major or minor topic of these publications. (ouhsc.edu)