Niacin. Medical search. Web

A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.

A transient reddening of the face that may be due to fever, certain drugs, exertion, stress, or a disease process.

A disease due to deficiency of NIACIN, a B-complex vitamin, or its precursor TRYPTOPHAN. It is characterized by scaly DERMATITIS which is often associated with DIARRHEA and DEMENTIA (the three D's).

Substances that lower the levels of certain LIPIDS in the BLOOD. They are used to treat HYPERLIPIDEMIAS.

2-, 3-, or 4-Pyridinecarboxylic acids. Pyridine derivatives substituted with a carboxy group at the 2-, 3-, or 4-position. The 3-carboxy derivative (NIACIN) is active as a vitamin.

An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.

A group of water-soluble vitamins, some of which are COENZYMES.

Dosage forms of a drug that act over a period of time by controlled-release processes or technology.

A condition due to deficiency in any member of the VITAMIN B COMPLEX. These B vitamins are water-soluble and must be obtained from the diet because they are easily lost in the urine. Unlike the lipid-soluble vitamins, they cannot be stored in the body fat.

Xanthurenic acid and its salts, formed as byproducts during the metabolism of tryptophan, are collectively referred to as xanthurenates, which can accumulate in conditions like hyperphenylalaninemia and may contribute to oxidative stress and cellular damage.

Effects of fatty acids and ketone bodies on basal insulin secretion in type 2 diabetes. (1/572)

The objective of this study was to assess the role of free fatty acids (FFAs) as insulin secretagogues in patients with type 2 diabetes. To this end, basal insulin secretion rates (ISR) in response to acute increases in plasma FFAs were evaluated in patients with type 2 diabetes and in age- and weight-matched nondiabetic control subjects during 1) intravenous infusion of lipid plus heparin (L/H), which stimulated intravascular lipolysis, and 2) the FFA rebound, which followed lowering of plasma FFAs with nicotinic acid (NA) and was a consequence of increased lipolysis from the subject's own adipose tissue. At comparable euglycemia, diabetic patients had similar ISR but higher plasma beta-hydroxybutyrate (beta-OHB) levels during L/H infusion and higher plasma FFA and beta-OHB levels during the FFA rebound than nondiabetic control subjects. Correlating ISR with plasma FFA plus beta-OHB levels showed that in response to the same changes in FFA plus beta-OHB levels, diabetic patients secreted approximately 30% less insulin than nondiabetic control subjects. In addition, twice as much insulin was secreted during L/H infusion as during the FFA rebound in response to the same FFA/beta-OHB stimulation by both diabetic patients and control subjects. Glycerol, which was present in the infused lipid (272 mmol/l) did not affect ISR. We concluded that 1) assessment of FFA effects on ISR requires consideration of effects on ISR by ketone bodies; 2) ISR responses to FFA/beta-OHB were defective in patients with type 2 diabetes (partial beta-cell lipid blindness), but this defect was compensated by elevated plasma levels of FFAs and ketone bodies; and 3) approximately two times more insulin was released per unit change in plasma FFA plus beta-OHB during L/H infusion than during the FFA rebound after NA. The reason for this remains to be explored. (+info)

Niacin accelerates intracellular ApoB degradation by inhibiting triacylglycerol synthesis in human hepatoblastoma (HepG2) cells. (2/572)

The mechanism by which the potent drug niacin decreases apoB-containing atherogenic lipoproteins and prevents coronary disease is unclear. Utilizing human hepatoblastoma (HepG2) cells as an in vitro model, we have examined the effect of niacin on intracellular degradation of apoB and the regulatory mechanisms involved in apoB processing. Niacin significantly increased apoB degradation in a dose- and time-dependent manner. Treatment of HepG2 cells with calpain inhibitor I [N-acetyl-leucyl-leucyl-norleucinal (ALLN), an inhibitor of certain protease-mediated apoB degradation], did not alter niacin-induced apoB degradation. Niacin decreased inhibition of oleate-mediated apoB degradation. Niacin dose-dependently inhibited the synthesis of both fatty acids and triacylglycerol (TG) by 20% to 40% as determined by the incorporation of 14C-acetate and 3H-glycerol into fatty acids and TG, respectively. Incubation of HepG2 cells with niacin significantly inhibited (by 12% to 15%) fatty acid esterification to produce TG as assessed by the incorporation of 3H-oleic acid into TG. 14C-acetate incorporation into cholesterol and phospholipids was unchanged. The activity of microsomal triglyceride transfer protein (MTP), a carrier protein for lipids, was not altered by pretreatment of cells with niacin. ApoB mRNA expression and 125I-LDL protein uptake were also unchanged. These data indicate that niacin accelerates hepatic intracellular post-translational degradation of apoB by selectively reducing triglyceride synthesis (through inhibiting both fatty acid synthesis and fatty acid esterification to produce TG) without affecting ALLN-inhibitable protease- or MTP-mediated intracellular apoB processing, resulting in decreased apoB secretion and hence lower circulating levels of the atherogenic lipoproteins. (+info)

Evidence for a new pathophysiological mechanism for coronary artery disease regression: hepatic lipase-mediated changes in LDL density. (3/572)

BACKGROUND: Small, dense LDL particles are associated with coronary artery disease (CAD) and predict angiographic changes in response to lipid-lowering therapy. Intensive lipid-lowering therapy in the Familial Atherosclerosis Treatment Study (FATS) resulted in significant improvement in CAD. This study examines the relationship among LDL density, hepatic lipase (HL), and CAD progression, identifying a new biological mechanism for the favorable effects of lipid-altering therapy. METHODS AND RESULTS: Eighty-eight of the subjects in FATS with documented coronary disease, apolipoprotein B levels >/=125 mg/dL, and family history of CAD were selected for this study. They were randomly assigned to receive lovastatin (40 mg/d) and colestipol (30 g/d), niacin (4 g/d) and colestipol, or conventional therapy with placebo alone or with colestipol in those with elevated LDL cholesterol levels. Plasma hepatic lipase (HL), lipoprotein lipase, and LDL density were measured when subjects were and were not receiving lipid-lowering therapy. LDL buoyancy increased with lovastatin-colestipol therapy (7.7%; P<0.01) and niacin-colestipol therapy (10.3%; P<0.01), whereas HL decreased in both groups (-14% [P<0.01] and -17% [P<0.01] with lovastatin-colestipol and niacin-colestipol, respectively). Changes in LDL buoyancy and HL activity were associated with changes in disease severity (P<0.001). In a multivariate analysis, an increase in LDL buoyancy was most strongly associated with CAD regression, accounting for 37% of the variance of change in coronary stenosis (P<0.01), followed by reduction in apolipoprotein Bl (5% of variance; P<0.05). CONCLUSIONS: These studies support the hypothesis that therapy-associated changes in HL alter LDL density, which favorably influences CAD progression. This is a new and potentially clinically relevant mechanism linking lipid-altering therapy to CAD improvement. (+info)

The protein phosphatase inhibitor cantharidin induces head and foot formation in buds of Cassiopea andromeda (Rhizostomae, Scyphozoa). (4/572)

The polyps of Cassiopea andromeda produce spindle shaped, freely swimming buds which do not develop a head (a mouth opening surrounded by tentacles) and a foot (a sticky plate at the opposite end) until settlement to a suited substrate. The buds, therewith, look very similar to the planula larvae produced in sexual reproduction. With respect to both, buds and planulae, several peptides and the phorbolester TPA have been found to induce the transformation into a polyp. Here it is shown that cantharidin, a serine/threonine protein phosphatase inhibitor, induces head and foot formation in buds very efficiently in a 30 min treatment, the shortest yet known efficient treatment. Some resultant polyps show malformations which indicate that a bud is ordinary polyp tissue in which preparatory steps of head and foot formation mutually block each other from proceeding. Various compounds related to the transfer of methyl groups have been shown to affect head and foot formation in larvae of the hydrozoon Hydractinia echinata. These compounds including methionine, homocysteine, trigonelline, nicotinic acid and cycloleucine are shown to also interfere with the initiation of the processes which finally lead to head and foot formation in buds of Cassiopea andromeda. (+info)

Inhibitors of poly (ADP-ribose) synthetase protect rat cardiomyocytes against oxidant stress. (5/572)

OBJECTIVE: Inhibitors of poly (ADP-ribose) synthetase (PARS) activity reduce the infarct size caused by regional myocardial ischaemia and reperfusion in the rabbit and rat in vivo. The mechanism of action of these inhibitors is unclear. Here we investigate the effects of the PARS inhibitor 3-aminobenzamide (3-AB) on infarct size caused by ischaemia and reperfusion of the isolated, perfused heart of the rat. We also investigate the role of PARS in the hydrogen peroxide-mediated cell injury/necrosis in rat cardiac myoblasts. METHODS: Rat isolated hearts perfused at constant pressure (80 mmHg) were subjected to 35 min of regional ischaemia and 2 h of reperfusion. Infarct size was determined at the end of the experiment using nitro-blue tetrazolium. 3-AB (300 microM) or 3-aminobenzoic acid (3-ABA, 300 microM) were infused during the reperfusion period. Rat cardiac myoblasts (H9c2 cells) were preincubated with the PARS inhibitors, 3-AB. nicotinamide (Nic) or 1,5-dihydroxyisoquinoline (ISO) or the inactive analogues 3-ABA or nicotinic acid (NicA) prior to exposure with hydrogen peroxide (1 mM). Cell injury was assessed by measuring mitochondrial respiration and cell necrosis by measuring the release of LDH. PARS activity was determined by measuring the incorporation of NAD into nuclear proteins. RESULTS: Regional ischaemia and reperfusion of the isolated rat heart resulted in an infarct size of 54% which was reduced by 3-AB, but not by 3-ABA. Exposure of rat cardiac myoblasts to hydrogen peroxide caused an increase in PARS activity and cell injury/necrosis which was attenuated by pretreatment with the PARS inhibitors. CONCLUSION: Inhibition of the activity of PARS attenuates the cell death associated with oxidant stress in rat cardiac myoblasts and heart. (+info)

Effect of mutagenesis at serine 653 of Arabidopsis thaliana acetohydroxyacid synthase on the sensitivity to imidazolinone and sulfonylurea herbicides. (6/572)

Resistance to sulfonylurea and imidazolinone herbicides can occur by mutations in acetohydroxyacid synthase (EC 4.1.3.18). Changing serine 653 to asparagine is known to cause insensitivity to imidazolinones but not to sulfonylureas. Here, S-653 of the Arabidopsis thaliana enzyme was mutated to alanine, threonine and phenylalanine. The purified mutated enzymes resemble wild-type in their enzymatic properties. The threonine and phenylalanine mutants are imidazolinone-resistant and the latter is also slightly sulfonylurea-resistant. The alanine mutant remains sensitive to both herbicides. The results suggest that the beta-hydroxyl group is not required for imidazolinone binding and that the size of the side-chain determines resistance. (+info)

The effects of acute nicotine on the metabolism of dopamine and the expression of Fos protein in striatal and limbic brain areas of rats during chronic nicotine infusion and its withdrawal. (7/572)

The effects of acute nicotine (0.5 mg/kg, s.c.) on dopamine (DA) metabolism and Fos protein expression in striatal and limbic areas of rats on the seventh day of chronic nicotine infusion (4 mg. kg(-1). d(-1)) and after 24 or 72 hr withdrawal were investigated. In saline-infused rats, acute nicotine elevated striatal and limbic 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) concentrations significantly. During the nicotine infusion, no such increases were seen in the striatum, but limbic HVA was somewhat elevated. After 24 hr withdrawal when no nicotine was found in the plasma, acute nicotine elevated striatal DOPAC and HVA and limbic HVA. However, the limbic DOPAC was unaffected. Acute nicotine increased Fos immunostaining (IS) in the caudate-putamen (CPU), the core of nucleus accumbens (NAcc), the cingulate cortex (Cg), and the central nucleus of amygdala (ACe) significantly. During nicotine infusion the nicotine-induced responses were attenuated in CPU and NAcc, whereas in ACe and Cg Fos immunostaining was increased as in saline-infused rats. After 24 hr withdrawal, acute nicotine did not increase Fos immunostaining in CPU, NAcc, and Cg, but increased it clearly in ACe. After 72 hr withdrawal, nicotine's effects were restored. Our findings suggest that the nicotinic receptors in the striatal areas are desensitized more easily than those in the limbic areas. Furthermore, the effects of nicotine on various DA metabolites differ. We also found evidence for long-lasting inactivation of nicotinic receptors in vivo regulating limbic dopamine metabolism and Fos expression in striatal and limbic areas. These findings might be important for the protective effects of nicotine in Parkinson's disease and in its dependence-producing properties. (+info)

Gemfibrozil, nicotinic acid and combination therapy in patients with isolated hypoalphalipoproteinemia: a randomized, open-label, crossover study. (8/572)

OBJECTIVES: To assess the effects of nicotinic acid (NA), gemfibrozil and combination therapy on the lipid profile of patients with clinical atherosclerotic disease and isolated hypoalphalipoproteinemia. BACKGROUND: Isolated hypoalphalipoproteinemia (low high density lipoprotein cholesterol [HDL-C] alone) accounts for a significant percentage of patients with premature atherosclerosis. However, it remains unclear whether currently available pharmacotherapy has the ability to favorably affect the lipid profile and therefore potentially reduce clinical events. METHODS: Twenty-three patients with clinically well-defined atherosclerosis and isolated hypoalphalipoproteinemia were prospectively randomized to receive gemfibrozil, NA or combination therapy in an open-label, crossover design trial to assess the effects on serum lipids. Lipid profiles and other relevant laboratory variables were monitored while the patients were on and off pharmacologic lipid-modulating therapy. RESULTS: In those 14 patients able to tolerate all forms of pharmacotherapy, HDL-C of 0.89 +/- 0.17 mmol/liter (34.5 +/- 6.5 mg/dl) increased by 15%, to 1.02 +/- 0.18 mmol/liter (39.7 +/- 7.1 mg/dl), while taking gemfibrozil (1,200 mg/day); by 35%, to 1.20 +/- 0.21 mmol/liter (46.5 +/- 8.1 mg/dl), while taking NA (mean dose 2,250 mg/day); and by 45%, to 1.29 +/- 0.19 mmol/liter (50.0 +/- 7.5 mg/dl), while taking combination therapy of gemfibrozil plus NA (p < 0.001 for all interventions as compared with baseline/washout; p < 0.005 NA vs. gemfibrozil; p < 0.001 combination therapy vs. gemfibrozil alone; p = 0.088 combination therapy vs. NA alone). Statistically significant favorable alterations were also observed with low density lipoprotein cholesterol (LDL-C), LDL-C/HDL-C, non-HDL-C/HDL-C, apolipoprotein (Apo) B and Apo B/Apo A1. CONCLUSIONS: In the majority of patients with clinical atherosclerotic disease and isolated hypoalphalipoproteinemia, pharmacologic therapy to raise HDL-C is not only feasible but is also effective with currently available agents, particularly when used in combination. (+info)

Niacin, also known as vitamin B3 or nicotinic acid, is a water-soluble vitamin that is essential for human health. It is a crucial component of the coenzymes NAD (nicotinamide adenine dinucleotide) and NADP (nicotinamide adenine dinucleotide phosphate), which play key roles in energy production, DNA repair, and cellular signaling.

Niacin can be obtained from various dietary sources, including meat, poultry, fish, legumes, whole grains, and fortified foods. It is also available as a dietary supplement and prescription medication. Niacin deficiency can lead to a condition called pellagra, which is characterized by symptoms such as diarrhea, dermatitis, dementia, and, if left untreated, death.

In addition to its role in energy metabolism and DNA repair, niacin has been shown to have potential benefits for cardiovascular health, including lowering LDL (low-density lipoprotein) cholesterol and triglyceride levels while raising HDL (high-density lipoprotein) cholesterol levels. However, high-dose niacin therapy can also have adverse effects, such as flushing, itching, and liver toxicity, so it should be used under the guidance of a healthcare professional.

"Flushing" is a medical term that refers to a sudden, temporary reddening of the skin, often accompanied by feelings of warmth. This occurs when the blood vessels beneath the skin dilate or expand, allowing more blood to flow through them. Flushing can be caused by various factors such as emotional stress, alcohol consumption, spicy foods, certain medications, or medical conditions like carcinoid syndrome or menopause. It is generally harmless but can sometimes indicate an underlying issue that requires medical attention.

Pellagra is a nutritional disorder caused by a deficiency of niacin (vitamin B3) or tryptophan, an amino acid that the body can convert into niacin. It's characterized by the four D's: diarrhea, dermatitis, dementia, and death. The skin lesions typically appear on sun-exposed areas and are often described as "photosensitive." Other symptoms can include inflammation of the mucous membranes, mouth sores, anemia, and depression. If left untreated, pellagra can be fatal. It was once common in regions where people subsisted on corn as a staple food, as corn is low in tryptophan and contains niacin in a form that is not easily absorbed by the body. Nowadays, it's most commonly seen in alcoholics, people with malabsorption disorders, and those with severely restricted diets.

Hypolipidemic agents are a class of medications that are used to lower the levels of lipids (fats) in the blood, particularly cholesterol and triglycerides. These drugs work by reducing the production or increasing the breakdown of fats in the body, which can help prevent or treat conditions such as hyperlipidemia (high levels of fats in the blood), atherosclerosis (hardening and narrowing of the arteries), and cardiovascular disease.

There are several different types of hypolipidemic agents, including:

1. Statins: These drugs block the action of an enzyme called HMG-CoA reductase, which is necessary for the production of cholesterol in the liver. By reducing the amount of cholesterol produced, statins can help lower LDL (bad) cholesterol levels and increase HDL (good) cholesterol levels.
2. Bile acid sequestrants: These drugs bind to bile acids in the intestines and prevent them from being reabsorbed into the bloodstream. This causes the liver to produce more bile acids, which requires it to use up more cholesterol, thereby lowering LDL cholesterol levels.
3. Nicotinic acid: Also known as niacin, this drug can help lower LDL and VLDL (very low-density lipoprotein) cholesterol levels and increase HDL cholesterol levels. It works by reducing the production of fatty acids in the liver.
4. Fibrates: These drugs are used to treat high triglyceride levels. They work by increasing the breakdown of fats in the body and reducing the production of VLDL cholesterol in the liver.
5. PCSK9 inhibitors: These drugs block the action of a protein called PCSK9, which helps regulate the amount of LDL cholesterol in the blood. By blocking PCSK9, these drugs can help lower LDL cholesterol levels.

It's important to note that hypolipidemic agents should only be used under the guidance and supervision of a healthcare provider, as they can have side effects and may interact with other medications.

Niacin, also known as nicotinic acid, is a form of vitamin B3 (B-complex vitamin) that is used by the body to turn food into energy. It is found in various foods including meat, fish, milk, eggs, green vegetables, and cereal grains. Niacin is also available as a dietary supplement and prescription medication.

As a medication, niacin is primarily used to treat high cholesterol levels. It works by reducing the production of LDL (bad) cholesterol in the body and increasing the levels of HDL (good) cholesterol. Niacin can also help lower triglycerides, another type of fat found in the blood.

Niacin is available in immediate-release, sustained-release, and extended-release forms. The immediate-release form can cause flushing of the skin, itching, tingling, and headaches, which can be uncomfortable but are not usually serious. The sustained-release and extended-release forms may have fewer side effects, but they can also increase the risk of liver damage and other serious side effects.

It is important to note that niacin should only be taken under the supervision of a healthcare provider, as it can interact with other medications and have potentially serious side effects.

Niacinamide, also known as nicotinamide, is a form of vitamin B3 (niacin). It is a water-soluble vitamin that is involved in energy production and DNA repair in the body. Niacinamide can be found in various foods such as meat, fish, milk, eggs, green vegetables, and cereal grains.

As a medical definition, niacinamide is a nutritional supplement and medication used to prevent or treat pellagra, a disease caused by niacin deficiency. It can also be used to improve skin conditions such as acne, rosacea, and hyperpigmentation, and has been studied for its potential benefits in treating diabetes, cancer, and Alzheimer's disease.

Niacinamide works by acting as a precursor to nicotinamide adenine dinucleotide (NAD), a coenzyme involved in many cellular processes such as energy metabolism, DNA repair, and gene expression. Niacinamide has anti-inflammatory properties and can help regulate the immune system, making it useful for treating inflammatory skin conditions.

It is important to note that niacinamide should not be confused with niacin (also known as nicotinic acid), which is another form of vitamin B3 that has different effects on the body. Niacin can cause flushing and other side effects at higher doses, while niacinamide does not have these effects.

Vitamin B Complex refers to a group of water-soluble vitamins that play essential roles in cell metabolism, cellular function, and formation of red blood cells. This complex includes 8 distinct vitamins, all of which were originally thought to be the same vitamin when first discovered. They are now known to have individual structures and specific functions.

1. Vitamin B1 (Thiamin): Necessary for energy production and nerve function.
2. Vitamin B2 (Riboflavin): Involved in energy production and growth.
3. Vitamin B3 (Niacin): Assists in energy production, DNA repair, and acts as a co-factor for various enzymes.
4. Vitamin B5 (Pantothenic Acid): Plays a role in the synthesis of Coenzyme A, which is vital for fatty acid metabolism.
5. Vitamin B6 (Pyridoxine): Needed for protein metabolism, neurotransmitter synthesis, hemoglobin formation, and immune function.
6. Vitamin B7 (Biotin): Involved in fatty acid synthesis, glucose metabolism, and nail and hair health.
7. Vitamin B9 (Folate or Folic Acid): Essential for DNA replication, cell division, and the production of red blood cells.
8. Vitamin B12 (Cobalamin): Necessary for nerve function, DNA synthesis, and the production of red blood cells.

These vitamins are often found together in various foods, and a balanced diet usually provides sufficient amounts of each. Deficiencies can lead to specific health issues related to the functions of each particular vitamin.

I couldn't find a medical definition specifically for "delayed-action preparations." However, in the context of pharmacology, it may refer to medications or treatments that have a delayed onset of action. These are designed to release the active drug slowly over an extended period, which can help to maintain a consistent level of the medication in the body and reduce the frequency of dosing.

Examples of delayed-action preparations include:

1. Extended-release (ER) or controlled-release (CR) formulations: These are designed to release the drug slowly over several hours, reducing the need for frequent dosing. Examples include extended-release tablets and capsules.
2. Transdermal patches: These deliver medication through the skin and can provide a steady rate of drug delivery over several days. Examples include nicotine patches for smoking cessation or fentanyl patches for pain management.
3. Injectable depots: These are long-acting injectable formulations that slowly release the drug into the body over weeks to months. An example is the use of long-acting antipsychotic injections for the treatment of schizophrenia.
4. Implantable devices: These are small, biocompatible devices placed under the skin or within a body cavity that release a steady dose of medication over an extended period. Examples include hormonal implants for birth control or drug-eluting stents used in cardiovascular procedures.

Delayed-action preparations can improve patient compliance and quality of life by reducing dosing frequency, minimizing side effects, and maintaining consistent therapeutic levels.

Vitamin B deficiency refers to a condition where an individual's body lacks adequate amounts of one or more essential Vitamin B compounds, including Vitamin B1 (thiamin), Vitamin B2 (riboflavin), Vitamin B3 (niacin), Vitamin B5 (pantothenic acid), Vitamin B6 (pyridoxine), Vitamin B7 (biotin), Vitamin B9 (folate), and Vitamin B12 (cobalamin). These water-soluble vitamins play crucial roles in various bodily functions, such as energy production, nerve function, DNA repair, and the formation of red blood cells.

Deficiency in any of these Vitamin B compounds can lead to specific health issues. For instance:

1. Vitamin B1 (thiamin) deficiency can cause beriberi, a condition characterized by muscle weakness, peripheral neuropathy, and heart failure.
2. Vitamin B2 (riboflavin) deficiency may result in ariboflavinosis, which presents with inflammation of the mouth and tongue, anemia, and skin disorders.
3. Vitamin B3 (niacin) deficiency can lead to pellagra, marked by diarrhea, dermatitis, dementia, and, if left untreated, death.
4. Vitamin B5 (pantothenic acid) deficiency is rare but can cause acne-like skin lesions and neurological symptoms.
5. Vitamin B6 (pyridoxine) deficiency may result in anemia, peripheral neuropathy, seizures, and skin disorders.
6. Vitamin B7 (biotin) deficiency can cause hair loss, skin rashes, and neurological symptoms.
7. Vitamin B9 (folate) deficiency can lead to megaloblastic anemia, neural tube defects in fetuses during pregnancy, and increased homocysteine levels, which may contribute to cardiovascular disease.
8. Vitamin B12 (cobalamin) deficiency can cause pernicious anemia, characterized by fatigue, weakness, neurological symptoms, and, if left untreated, irreversible nerve damage.

Deficiencies in these vitamins can arise from inadequate dietary intake, malabsorption syndromes, or certain medications that interfere with absorption or metabolism. It is essential to maintain a balanced diet and consider supplementation if necessary under the guidance of a healthcare professional.

I'm sorry for any confusion, but "xanthurenates" is not a recognized term in medicine or physiology. It seems that you might be referring to "xanthurenic acid," which is a metabolic byproduct produced during the breakdown of the amino acid tryptophan. An accumulation of xanthurenic acid can occur due to certain genetic disorders, such as Hartnup disease or defects in the coenzyme Q10 synthesis pathway. However, without more context, it's difficult for me to provide a precise definition related to your specific question. If you could provide additional information, I would be happy to help further!

Plasma concentrations of niacin and niacin metabolites are not useful markers of niacin status. Urinary excretion of the ... November 2008). "Extended-release niacin/laropiprant: reducing niacin-induced flushing to better realize the benefit of niacin ... also known as niacin receptor 1 (NIACR1). Unlike niacin, nicotinamide does not activate NIACR1; however, both niacin and ... Long-term niacin therapy was also associated with an increase in the risk of new-onset type 2 diabetes. High doses of niacin ...

https://en.wikipedia.org/wiki/Niacin

The known human niacin receptors (or nicotinic acid receptors, abbreviated NIACR) are: Niacin receptor 1 (NIACR1, formerly ... known as GPR109A) Niacin receptor 2 (NIACR2, formerly known as GPR109B) This article includes a list of related items that ...

https://en.wikipedia.org/wiki/Niacin_receptor

Niacin, or nicotinic acid, is an organic compound. Niacin may also refer to: Vitamin B3, colloquially referred to as niacin ... Niacin (band), with Billy Sheehan This disambiguation page lists articles associated with the title Niacin. If an internal link ...

https://en.wikipedia.org/wiki/Niacin_(disambiguation)

... excreting the excess niacin into the culture media, thus allowing it to be detected using the niacin test. The niacin test is ... Niacin is water-soluble, so the culture media can be tested for the presence of niacin to determine whether a Mycobacterium ... If the liquid in the tube is clear, there are no excess amounts of niacin and the test is negative. A positive niacin test does ... The niacin test detects niacin (nicotinic acid) in aqueous extracts of a culture. M. tuberculosis strains that test negative ...

https://en.wikipedia.org/wiki/Niacin_test

Deep album at Niacin's official website Niacin's Deep album at ProgArchives Adle, David R.. Deep at AllMusic. Retrieved 2013-03 ... Deep is the third studio album from the jazz rock fusion trio Niacin, released in March 2000. The album is heavily loaded with ...

https://en.wikipedia.org/wiki/Deep_(Niacin_album)

". "Niacin". Niacin. Retrieved 2022-04-21. "John Novello". Discogs. Retrieved 2022-04-21. "John Novello". Discogs. Retrieved ... Wood Stimela Smak Mezzoforte National Health Niacin Nucleus Neal Schon Opafire (musical project) Oregon Ozric Tentacles OHM ...

https://en.wikipedia.org/wiki/List_of_jazz_fusion_musicians

While niacin has no known efficacy in psychiatric disease, the use of niacin in combination with statins and other medical ... Large doses of niacin can cause liver damage, peptic ulcers, and skin rashes. Even normal doses can be associated with skin ... Some vitamins are toxic in high doses, including niacin (B3), cholecalciferol (D) and tocopherol (E). The view of the medical ... Guyton JR (2007). "Niacin in cardiovascular prevention: mechanisms, efficacy, and safety". Current Opinion in Lipidology. 18 (4 ...

https://en.wikipedia.org/wiki/Orthomolecular_medicine

"Niacin". Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, ... involved in the kynurenine pathway of synthesis of niacin from tryptophan can lead to pellagra (niacin deficiency). lifestyle ... Vitamin fortification programs exist in one or more countries for folate, niacin, riboflavin, thiamin, vitamin A, vitamin B6, ... "Fact Sheet for Health Professionals - Niacin". National Institutes of Health Office of Dietary Supplements. 18 November 2022 [ ...

https://en.wikipedia.org/wiki/Vitamin_deficiency

"Niacin". AllMusic. Retrieved October 26, 2018. Niacin Biography, musicianguide.com Prokofiev, Dane (October 6, 2012). An ... Big, Niacin, and The Winery Dogs. He is also known for his "lead bass" playing style, including the use of chording, two-handed ... Official website Niacin official website Billy Sheehan interview on Lane Music, 2021 Billy Sheehan interview on Guitar.com 2014 ... The band's name comes from the timbral foundation of the Hammond B3 organ; vitamin B3 is also known as niacin.[citation needed ...

https://en.wikipedia.org/wiki/Billy_Sheehan

Despite the presence of the de novo pathway, the salvage reactions are essential in humans; a lack of niacin in the diet causes ... Henderson LM (1983). "Niacin". Annu. Rev. Nutr. 3: 289-307. doi:10.1146/annurev.nu.03.070183.001445. PMID 6357238. Rajman L, ... Then, in 1939, he provided the first strong evidence that niacin is used to synthesize NAD+. In the early 1940s, Arthur ... Alternatively, more complex components of the coenzymes are taken up from nutritive compounds such as niacin; similar compounds ...

https://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide

... niacin 50%; phosphorus 20%; magnesium 25%. Ingredients: whole wheat kernels, whole flaxseed, salt, barley malt, niacin, ...

https://en.wikipedia.org/wiki/Uncle_Sam_(cereal)

1998). "Chapter 6 - Niacin". Dietary Reference Intakes for Tjiamine, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, ... 1998). "Chapter 6 - Niacin". Dietary Reference Intakes for Thiamine, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, ... 1998). "Chapter 9 - Vitamin B12". Dietary Reference Intakes for Thiamine, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, ... 1998). "Chapter 8 - Folate". Dietary Reference Intakes for Thiamine, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, ...

https://en.wikipedia.org/wiki/B_vitamins

As a supplement, it is used by mouth to prevent and treat pellagra (niacin deficiency). While nicotinic acid (niacin) may be ... Niacin (Nicotinic Acid, Nicotinamide)". Vitamins, 11. Niacin (Nicotinic Acid, Nicotinamide. Ullmann's Encyclopedia of ... However, the human body can produce NAD+ from the amino acid tryptophan and niacin without our ingestion of nicotinamide. NAD+ ... Niacinamide is the preferred treatment for pellagra, caused by niacin deficiency. Niacinamide cream is used as a treatment for ...

https://en.wikipedia.org/wiki/Nicotinamide

Such time-dependent release of niacin and menthol, in an equimolar ratio, prevents the excessive niacin-flush effect that is ... Niacin has also been used and tested for the purpose of enhancing detoxification by removing skin lipid-stored xenobiotics. In ... Niacin is a precursor to coenzyme nicotinamide adenine dinucleotide (NAD), which is essential to all cellular processes ... It is the ester of nicotinic acid (niacin, vitamin B3) and menthol. At room temperature, menthyl nicotinate is a colorless, ...

https://en.wikipedia.org/wiki/Menthyl_nicotinate

Niacin Niacinamide "N-methylnicotinamide". DrugBank. "Nicotinyl methylamide". Inxight Drugs. National Center for Advancing ...

https://en.wikipedia.org/wiki/Nicotinyl_methylamide

Niacin: The Real Story: Learn about the Wonderful Healing Properties of Niacin, with Andrew W. Saul and Harold D. Foster. Basic ... Hoffer thought niacin could be used as a methyl acceptor to prevent the conversion of noradrenaline into adrenaline and that ... At such high doses niacin acts like a drug rather than a vitamin and may have side effects of intense flushing of the face and ... High-dose niacin has since become a treatment option for individuals with high blood cholesterol and related blood lipid ...

https://en.wikipedia.org/wiki/Abram_Hoffer

... niacin (B3), and folic acid (B9). Wheat flour sold in Colombia must by law be fortified with vitamin B1, vitamin B2, niacin (B3 ... and therefore was not contributing to the overall intake of niacin.[medical citation needed] Diseases associated with niacin ... Flour loses nutritional value due to the way grains are processed; Enriched Flour has iron, folic acid, niacin, riboflavin, and ... Vitamin fortification programs exist in one or more countries for folate, niacin, riboflavin, thiamine, vitamin A, vitamin B6, ...

https://en.wikipedia.org/wiki/Food_fortification

A small serving of sardines once a day can provide 13% of vitamin B2; roughly one-quarter of niacin; and about 150% of the ...

https://en.wikipedia.org/wiki/Sardine

Pellagra, caused by niacin deficiency. Chloride, sodium, potassium, zinc and/or iodine deficiency, as these elements are needed ...

https://en.wikipedia.org/wiki/Achlorhydria

... niacin, nicotinamide → NADPH) • Vitamin B6 (pyridoxine, pyridoxamine, pyridoxal → pyridoxal phosphate) • Vitamin B9 (folic acid ...

https://en.wikipedia.org/wiki/List_of_dopaminergic_drugs

... caused by a niacin deficiency); tetany (caused by deficiencies of calcium, magnesium, and Vitamin D); rickets (also caused by a ...

https://en.wikipedia.org/wiki/Francisco_Xavier_de_Mendonça_Furtado

... and niacin; infections, immune disorders, liver or kidney failure, metabolic disorders such as Kufs disease, and some ...

https://en.wikipedia.org/wiki/Dementia

It also contains potassium, calcium, niacin.: 151 : 168 [?] Most of the soybean isoflavones are left in okara, as well as ...

https://en.wikipedia.org/wiki/Okara_(food)

... is a niacin receptor agonist. Jung, J. K.; Johnson, B. R.; Duong, T; Decaire, M; Uy, J; Gharbaoui, T; Boatman, P. D.; ... agonists of the high and low affinity niacin receptors, GPR109a and GPR109b". J. Med. Chem. 50 (7): 1445-8. doi:10.1021/ ...

https://en.wikipedia.org/wiki/Acifran

1937 Niacin Niacin, also known as vitamin B3, is a water-soluble vitamin which prevents the deficiency disease pellagra. Niacin ... "Niacin Augments the Benefits of Statins". Life Enhancement Products, Inc. Kaufman, Leslie (August 21, 1999). "Michael Sveda, ...

https://en.wikipedia.org/wiki/Timeline_of_United_States_discoveries

Deramciclane Tiagabine Niacin Macdonald, R.L. (2012). Eadie, Mervyn J.; Vajda, Frank J. E. (eds.). Antiepileptic drugs: ...

https://en.wikipedia.org/wiki/Nipecotic_acid

The US Recommended Dietary Allowance for niacin for adult women is 14 mg/day and for adult men 16 mg/day. Niacin is available ... niacin is also available as a dietary supplement at 500 to 1,000 mg/tablet. Niacin has sometimes been used in combination with ... Niacin tablet label Updated March 14, 2013. Page accessed Feb 11, 2016 Keene D, Price C, Shun-Shin MJ, Francis DP (July 2014 ... Schandelmaier S, Briel M, Saccilotto R, Olu KK, Arpagaus A, Hemkens LG, Nordmann AJ (June 2017). "Niacin for primary and ...

https://en.wikipedia.org/wiki/Megavitamin_therapy

... and Niacin Supplementation". New England Journal of Medicine. 377 (6): 544-552. doi:10.1056/NEJMoa1616361. ISSN 0028-4793. PMID ...

https://en.wikipedia.org/wiki/GeneMatcher

Note: niacin for maize assumes freed niacin. A raw yellow dent corn B raw unenriched long-grain white rice C raw hard red ... Although maize naturally contains niacin, an important nutrient, it was not bioavailable without the process of nixtamalization ... niacin (but see Pellagra warning below), pantothenic acid (B5) and folate (right table for raw, uncooked kernels, USDA Nutrient ... it coincidentally liberates the B-vitamin niacin, the lack of which was the underlying cause of the condition known as pellagra ...

https://en.wikipedia.org/wiki/Maize

Tarr, J. B.; Arditti, J. (1982). "Niacin Biosynthesis in Seedlings of Zea mays". Plant Physiology. 69 (3): 553-556. doi:10.1104 ...

https://en.wikipedia.org/wiki/Pyridine

https://en.wikipedia.org/wiki/Niacin

Niacin: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before taking niacin,. *tell your doctor and pharmacist if you are allergic to niacin, any other medications, or any of the ... Niacin is also used to prevent and treat pellagra (niacin deficiency), a disease caused by inadequate diet and other medical ... Continue to take niacin even if you feel well. Do not stop taking niacin without talking to your doctor. ...

https://medlineplus.gov/druginfo/meds/a682518.html

EWGs Skin Deep rates thousands of personal care product ingredients, culled from ingredient labels on products, based on hazard information pulled from the scientific literature and industry, academic and regulatory databases.

https://www.ewg.org/skindeep/ingredients/704133-NIACIN/

Explore Niacins discography including top tracks, albums, and reviews. Learn all about Niacin on AllMusic. ... Niacin. Having played straightforward hard rock with Mr. Big since the tail end of the 80s, bass virtuoso Billy Sheehan formed ... Niacin as an outlet for his jazz fusion and prog rock inclinations during the mid-90s.… ...

https://www.allmusic.com/artist/niacin-mn0000865691

Discover High Bias by Niacin released in 1998. Find album reviews, track lists, credits, awards and more at AllMusic. ... Niacin must have been quite a learning experience for its bassist Billy Sheehan, whose main pre-Niacin gig had been his hard ... Niacin showed a great deal of promise on its self-titled debut album of 1996, and there were no signs of the infamous sophomore ... When he formed Niacin with organist/keyboardist John Novello and drummer extraordinaire Dennis Chambers in the mid-90s, ...

https://www.allmusic.com/album/high-bias-mw0000598932

The resulting name niacin was derived from nicotinic acid + vitamin. Niacin refers to both nicotinic acid and nicotinamide. ... Niacin in itself is not toxic, but the chemicals converted by niacin are toxic to the skin and liver in overdose, and high ... Niacin is found in meat, fish, nuts, green vegetables, and yeast, among other sources. Niacin deficiency results in pellagra, ... Dietary niacin deficiency has been prominent historically in areas where people eat corn, a grain that is low in niacin, as a ...

https://www.newworldencyclopedia.org/entry/Niacin

The same reasoning was cited for pulling its approval of Advicor (niacin extended-release/lovastatin) and Simcor (niacin ... The decision affects the indication of niacin extended-release (Niaspan, AbbVie) and fenofibric acid (Trilipix, AbbVie), as ... "Consistent with this conclusion, the FDA has determined that the benefits of niacin ER tablets and fenofibric-acid [delayed- ... Cite this: FDA Pulls Approval of Niacin, Fibrate in Combo with Statins - Medscape - Apr 15, 2016. ...

https://www.medscape.com/viewarticle/862022

Based on the broken-line model analysis of SGR against dietary niacin level, the dietary niacin requirement of juvenile crabs ... Crabs were fed with the control diet (0.89 mg/kg) or niacin-supplemented diets (170.54 mg/kg, 347.05 mg/kg, 587.59 mg/kg, ... The niacin content in the hepatopancreas of crabs in G1 and G2 was significantly lower than that of the other four groups (, ... dietary niacin significantly affected the intestinal histomorphology of crabs, including the number of folds (NF), height of ...

https://www.hindawi.com/journals/anu/2022/8348000/

It may be possible to lower your intake of niacin, take it in divided doses or shift to nicotinamide, which is a form of niacin ... BLONZ: Can I be allergic to niacin (vitamin B-3) to the point where it is harmful to my health? I stopped taking niacin because ... DEAR S.T.: It is doubtful that its niacin, an essential nutrient, that you are allergic to. Niacin is involved in the health ... What you are probably experiencing is a niacin flush, which occurs when large doses of niacin (about 10 times the RDA) dilate ...

https://www.uexpress.com/health/on-nutrition/2016/05/10

Kepner CH Personal experiences with LSD and Niacin Saskatchewan Psychiatry. Serv. J. 1953 1:25 ... and feelings after taking LSD by mouth following a 48 hour period of preparation consisting of massive doses of niacin ( ... "Personal experiences with LSD and Niacin" Saskatchewan Psychiatry. Serv. J.. 1953;1:25. ...

https://www.erowid.org/references/refs_view.php?ID=3982&C=Hof&S=1958

High LDL cholesterol levels can increase your risk of heart disease Niacin, one of many natural cholesterol lowering ... What is Niacin?. Niacin is actually one of two components of Vitamin B3. Tryptophan, which is found in turkey and some dairy ... You can find niacin in many of the foods you consume, including fish, green vegetables, and grains. Niacin is often available ... Another difference between niacin supplements and prescription cholesterol medication are the side effects. With niacin, you ...

https://www.nutralegacy.com/blog/general-healthcare/niacin-helps-to-lower-ldl-cholesterol/

... statins and high-dose niacin on cholesterol and safety. ... Should I take niacin to raise my HDLs?. Learn more about niacin ... For more details about the effects of statins given with high-dose niacin, see the Niacin section of the B Vitamins Product ... www.consumerlab.com/answers/can-i-combine-red-yeast-rice-with-niacin-to-further-lower-my-cholesterol/red-yeast-rice-and-niacin/ ... If I already take red yeast rice, would adding high-dose niacin help further reduce my cholesterol levels, and would this be ...

https://www.consumerlab.com/answers/can-i-combine-red-yeast-rice-with-niacin-to-further-lower-my-cholesterol/red-yeast-rice-and-niacin/?search=High%20Blood%20Pressure

... was niacin deficient as a duckling. We quickly corrected it with niacin rich foods and adding a niacin supplement to their food ... One of my ducks, Yoda, was niacin deficient as a duckling. We quickly corrected it with niacin rich foods and adding a niacin ... One of my ducks, Yoda, was niacin deficient as a duckling. We quickly corrected it with niacin rich foods and adding a niacin ... Layer and oyster shell will help with egg-laying, but the niacin def needs liquid B complex. TSC carries Durvet Liquid B ...

https://www.backyardchickens.com/threads/possible-niacin-deficiency.1498652/

Decrease Quantity of Niacin 250 250 tablets Generated with Avocode.. ... Increase Quantity of Niacin 250 250 tablets Generated with Avocode.. ... Niacin plays an essential role in the activities of various enzymes involved in the metabolism of carbohydrates and fats, the ... Niacin 250(TM) is time released to minimize the intensity of the flushing response, which varies from person to person. ...

https://acuatlanta.net/source-naturals/niacin-250-250-tablets

Even low doses of niacin supplements can cause "niacin flush," flushing along with possible itching and discomfort of the skin ... Niacin (a.k.a. vitamin B3) is a water-soluble vitamin, which means that daily excess is lost in the urine. Because of this high ... Thankfully, you can find niacin in a wide variety of foods (see below). Not getting enough of this nutrient can lead to ... As usual, food sources of niacin are preferable because high doses from supplements have been shown to cause liver damage, skin ...

https://www.foodnetwork.com/healthyeats/2011/02/nutrient-to-know-niacin

Niacin-Flush Free online at Vitacost.com. Enjoy big savings and have these healthy essentials delivered to your door! ... HomeVitamins & SupplementsLetter VitaminsVitamin BVitamin B3 - NiacinNiacin-Flush Free. Niacin-Flush Free. ... Vitacost Niacin (Vitamin B3) Non-Flushing -- 1000 mg per serving - 300 Capsules ...

https://www.vitacost.com/niacin-flush-free

Average 6-month serum phosphorus level was significantly lower in CKD patients who received niacin than those who did not. ... BOSTON-Niacin may be an option for phosphate control in patients with advanced chronic kidney disease (CKD), according to data ... They stated that niacin has the advantages of daily administration without regard to meals and generic availability. ... The authors noted that studies have shown that niacin lowers serum phosphorus by inhibiting the expression of type IIb sodium- ...

https://www.renalandurologynews.com/home/conference-highlights/national-kidney-foundation-annual-meeting/nkf-2016-spring-clinical-meeting/niacins-phosphorus-lowering-effect-confirmed/

Shop for Olympian Labs Vndyl Sulfate Niacin (250 CT) at Frys Food Stores. Find quality health products to add to your Shopping ...

https://www.frysfood.com/p/olympian-labs-vndyl-sulfate-niacin/0071001310061

Niacin Deficiency and Nutritional Disorders - Learn about from the Merck Manuals - Medical Professional Version. ... Etiology of Niacin Deficiency Primary niacin deficiency results from extremely inadequate intake of both niacin and tryptophan ... Secondary niacin deficiency may be due to diarrhea, cirrhosis Cirrhosis Cirrhosis is a late stage of hepatic fibrosis that has ... Bound niacin, found in maize, is not assimilated in the gastrointestinal tract unless it has been previously treated with ...

https://www.merckmanuals.com/professional/nutritional-disorders/vitamin-deficiency-dependency-and-toxicity/niacin-deficiency

HealthDay)-Extended-release (ER) niacin is associated with progressive and reversible thrombocytopenia, according to a letter ... there was a marked improvement in hemoglobin upon discontinuation of niacin-ER. "In conclusion, Niacin-ER is known to cause ... The patients were on niacin-ER daily for 59 months, on average, at a median dose of 2,250 mg. Platelets recovered by an average ... The researchers found that platelets recovered quickly after cessation of niacin-ER, with improvement noted within a month of ...

https://medicalxpress.com/news/2016-04-niacin-er-overlooked-thrombocytopenia.html

... niacin doesn t likely relate directly to weight loss. But eating a well-balanced diet containing plenty... ... Although getting plenty of niacin, a form of vitamin B-3, in your diet helps keep energy levels high, ... Niacin and weight loss tips. Lossing Weight / March 23, 2021. Although getting plenty of niacin, a form of vitamin B-3, in your ... Niacin and other B vitamins help your body produce energy from the foods you eat. Getting too little niacin may drain your ...

http://meridia-nextday.org/niacin-and-weight-loss-tips

Improve your day-to-day wellness with Solgar Niacin 500 mg 100 Veg Caps from Swanson Health Products. ... Niacin is also known as vitamin B3. Solgars formula delivers 500 mg niacin in each vegetable capsule. Free of gluten, wheat, ... CAUTION: FOLLOW LABEL DIRECTIONS. Do not take more than 500 mg of niacin per day or switch to more than 250 mg of sustained ... Solgar Niacin 500 mg supports growth, healthy tissues, cardiovascular health and helps maintain healthy lipid levels already ...

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Shop for Kal Niacin (50 mg - 200 Tablets) at Harris Teeter. Find quality health products to add to your Shopping List or order ... Niacin . Other Ingredients : Cellulose , Stearic Acid , Silica and Magnesium Stearate .. Allergen Info. Free from Does Not ...

https://www.harristeeter.com/p/kal-niacin/0002124582435

The Vitamin B3 is commonly known as Niacin. Health Benefits of Vitamin B3 or Niacin. Some of the important health benefits of ... Vitamin B3 (Niacin) - Uses, Benefits, Sources and Dosage. Like other vitamins, Vitamin B3 is also an important one for general ... These three forms are Nicotinic acid, Niacin amide and Inositol Hexaniacinate. These are available in the form of tablets, ... The nicotinic acid is good for healthy cholesterol levels while niacin amide is common among the nutritional supplements. ...

https://www.planetayurveda.com/library/vitamin-b3/

High dietary niacin intake is associated with decreased chromosome translocation frequency in airline pilots - Volume 105 Issue ... 6Hageman, GJ & Stierum, RH (2001) Niacin, poly(ADP-ribose) polymerase-1 and genomic stability. Mutat Res 475, 45-56.CrossRef ... 37Kirkland, JB (2009) Niacin status, NAD distribution and ADP-ribose metabolism. Curr Pharm Des 15, 3-11.CrossRefGoogle Scholar ... In particular, niacin as a precursor of NAD is required for DNA synthesis as well as the activity of the enzyme, poly(ADP- ...

https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/high-dietary-niacin-intake-is-associated-with-decreased-chromosome-translocation-frequency-in-airline-pilots/D69D0AB9C39BFFC04B5BB55A67BFFDFC

... the increasing grain contribution to niacin due to niacin-fortification, and the increasing niacin-fortified ready-to-eat ... Li D, Sun WP, Zhou YM, Liu QG, Zhou SS, Luo N, Bian FN, Zhao ZG, Guo M. Chronic niacin overload may be involved in the ... Excess niacin consumption may be a major factor in the increased obesity prevalence in US children. ... Chronic niacin overload may be involved in the increased prevalence of obesity in US children ...

https://www.wjgnet.com/1007-9327/abstract/v16/i19/2378.htm

Niacin Energy Punch is designed to use on goats before and after kidding. ... Niacin Energy Punch™ is designed to use on goats before and after kidding. Niacin Energy Punch provides Propylene Glycol, ... Be the first to review "Goats Prefer: Niacin Energy Punch 8 oz" Cancel reply. Your email address will not be published. ... Niacin Energy Punch is designed to use on goats before and after kidding. ...

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Although niacins mechanisms of action have not been substantiated from controlled clinical trials, this agent may have ... Important side effects of niacin include flushing, nausea and fainting. Conclusion: Although niacins mechanisms of action have ... Intravenous and oral niacin has been employed in the treatment of acute and chronic migraine and tension-type headaches, but ... We aimed to systematically review the evidence of using intravenous and/or oral niacin as a treatment for migraine headaches, ...

https://pubmed.ncbi.nlm.nih.gov/15673472/

Niacin has been used for many years in the belief that it would help patients and prevent heart attacks and stroke, but we now ... Niacin is a type of B-vitamin, but the therapeutic doses used to control cholesterol are about 100 times higher than the amount ... ER niacin/laropiprant has been approved in 70 countries and was being sold in 40. The Food and Drug Administration was awaiting ... Patients receiving ER niacin/laropiprant had a similar number of major vascular events as patients receiving placebo (13.2 vs. ...

https://www.acc.org/About-ACC/Press-Releases/2013/03/09/20/40/HPS2-THRIVE

Buy Life Extension Mix TABS with Extra Niacin 100 Tabs. Same Day Shipping! ... Life Extension Mix TABS with Extra Niacin 100 Tabs. Life Extension Mix TABS with Extra Niacin contains a wide variety of ... Life Extension Mix TABS with Extra Niacin without Copper 315 Tabs Life Extension Mix TABS with Extra Niacin without Copper is a ... Life Extension Mix with Extra Niacin 315 Tabs Life Extension Mix with Extra Niacin contains a wide variety of vitamins and ...

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Niacin, also known as nicotinic acid, is an organic compound and a vitamer of vitamin B3, an essential human nutrient. (wikipedia.org)
Niacin , also known as nicotinic acid or vitamin B 3 , is a vitamin whose derivatives NAD, NADH, NAD + , and NADP play essential roles in energy metabolism in the living cell and DNA repair. (newworldencyclopedia.org)
In this paper the author attempts to describe, as accurately as possible, his impressions and feelings after taking LSD by mouth following a 48 hour period of preparation consisting of massive doses of niacin (Nicotinic acid) by mouth. (erowid.org)
Niacin (nicotinic acid, nicotinamide) derivatives include nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), which are coenzymes in oxidation-reduction reactions. (merckmanuals.com)
These three forms are Nicotinic acid, Niacin amide and Inositol Hexaniacinate. (planetayurveda.com)
The nicotinic acid is good for healthy cholesterol levels while niacin amide is common among the nutritional supplements. (planetayurveda.com)
Niacin, another B vitamin which occurs in two forms (nicotinic acid and nicotinamide), also contributes to the maintenance of DNA integrity due to several important roles. (cambridge.org)
Sustained-Release Niacin with NiaXtend from Doctor's Best is a dietary supplement delivered as Nicotinic Acid. (swansonvitamins.com)
Niacin (vitamin B-3) also known as nicotinic acid, is a member of the B family of vitamins and is found in the company of other B vitamins-vitamin B1 (thiamine), vitamin B2 (riboflavin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B12 (cyanocabalamin) and folic acid. (kingsoopers.com)
Flushing is also a common side effect of taking niacin in the form of nicotinic acid. (seekinghealth.com)
It is a temporary reaction to the ingestion of niacin (nicotinic acid) from supplements. (seekinghealth.com)
A single Non-GMO tablet provides 100 mg of Niacin (as Nicotinic Acid), which is 625% of your daily recommended value! (pipingrock.com)
Anyone who has taken niacin, at least the right kind of niacin (that being nicotinic acid) has probably experienced the niacin flush side effect. (nutribody.com)
Niacin (nicotinic acid) in large amounts is sometimes used to lower low-density lipoprotein (LDL) cholesterol and triglyceride levels and to increase high-density lipoprotein (HDL) cholesterol levels. (msdmanuals.com)

Although niacin and nicotinamide are identical in their vitamin activity, nicotinamide does not have the same pharmacological, lipid-modifying effects or side effects as niacin, i.e., when niacin takes on the -amide group, it does not reduce cholesterol nor cause flushing. (wikipedia.org)
Niacin is both a vitamin, i.e., an essential nutrient, marketed as a dietary supplement, and in the US, a prescription medicine. (wikipedia.org)
Niacin or nicotinamide (niacinamide) are used for prevention and treatment of pellagra, a disease caused by lack of the vitamin. (wikipedia.org)
Niacin is a B-complex vitamin. (medlineplus.gov)
Niacin is a water-soluble vitamin with stable physicochemical properties. (hindawi.com)
DEAR DR. BLONZ: Can I be allergic to niacin (vitamin B-3) to the point where it is harmful to my health? (uexpress.com)
Niacin is actually one of two components of Vitamin B3. (nutralegacy.com)
Niacin (a.k.a. vitamin B3) is a water-soluble vitamin, which means that daily excess is lost in the urine. (foodnetwork.com)
Overview of Vitamins Vitamins may be Fat soluble (vitamins A, D, E, and K) Water soluble (B vitamins and vitamin C) The B vitamins include biotin, folate, niacin, pantothenic acid, riboflavin (B2), thiamin (B1). (merckmanuals.com)
Although getting plenty of niacin, a form of vitamin B-3, in your diet helps keep energy levels high, niacin doesn't likely relate directly to weight loss. (meridia-nextday.org)
The Vitamin B3 is commonly known as Niacin. (planetayurveda.com)
Experimental studies suggest that B vitamins such as niacin, folate, riboflavin, vitamin B 6 and vitamin B 12 may protect against DNA damage induced by ionising radiation (IR). (cambridge.org)
Niacin, also known as vitamin B-3, is a member of the B-complex. (swansonvitamins.com)
SAN FRANCISCO (March 9, 2013) - A highly anticipated study evaluating a combination of the vitamin niacin with the anti-flushing agent laropiprant finds the therapy provides no benefit to and may even be harmful for patients with vascular disease, according to research presented today at the American College of Cardiology's 62nd Annual Scientific Session. (acc.org)
Niacin is a type of B-vitamin, but the therapeutic doses used to control cholesterol are about 100 times higher than the amount recommended as part of daily intake. (acc.org)
What are the key benefits of Vitacost® Niacin (Vitamin B3)? (kingsoopers.com)
Lima Beans Nutrition Vegetable has Vitamin B Complex, Niacin Amino Acids Pectin Dietary Fiber Helps Cholesterol. (lifeplusvitamins.com)
Unlike other nutrients, niacin, also known as vitamin B3, causes something known as the niacin flush . (seekinghealth.com)
Niacin ( vitamin B3 ) is a water-soluble B vitamin. (seekinghealth.com)
Niacin flushing is a side effect of taking higher doses of vitamin B3 supplements. (seekinghealth.com)
Niacin can be obtained through vitamin-rich foods such as chicken, turkey and fish. (pipingrock.com)
Niacin 500mg Extended Release tablets contain Niacin (vitamin B3), a water soluble vitamin with an important role in cellular metabolism. (vitalnutrientspro.co)
Lower (LDL) Cholesterol FAST With Niacin (Vitamin B3) Supplementation! (healthycholesterolclub.com)
Niacin is a vitamin and it is considered a nutrient that is essential to human life and development. (healthycholesterolclub.com)
Niacin (Vitamin B3) is well known for its ability to encourage vasodilation and help hard-worked muscles get the oxygen and nutrients needed to fuel an intense workout and improve muscle growth and strength. (slimmersweekly.com)
The 3-carboxy derivative (NIACIN) is active as a vitamin. (bvsalud.org)

When niacin is used as a medicine to treat elevated cholesterol and triglycerides, daily doses range from 500 to 3,000 mg/day. (wikipedia.org)
At therapeutic doses, niacin is a cholesterol-lowering medication. (medlineplus.gov)
Extremely high doses of niacin can cause niacin maculopathy, a thickening of the macula and retina, which leads to blurred vision and blindness (Gass 1973). (newworldencyclopedia.org)
Niacin in itself is not toxic, but the chemicals converted by niacin are toxic to the skin and liver in overdose, and high doses of niacin should only be reached with gradual increase. (newworldencyclopedia.org)
Studies in laboratory animals have demonstrated behavioral changes when large doses of niacin are given (Sullivan 1958). (newworldencyclopedia.org)
What you are probably experiencing is a 'niacin flush,' which occurs when large doses of niacin (about 10 times the RDA) dilate the capillaries, the small blood vessels near the skin. (uexpress.com)
It may be possible to lower your intake of niacin, take it in divided doses or shift to nicotinamide, which is a form of niacin that doesn't induce the flushing effect. (uexpress.com)
As usual, food sources of niacin are preferable because high doses from supplements have been shown to cause liver damage, skin rashes and digestive problems. (foodnetwork.com)
Even low doses of niacin supplements can cause "niacin flush," flushing along with possible itching and discomfort of the skin (usually the face). (foodnetwork.com)
Consuming higher doses of niacin by taking supplements is likely effective for treating high cholesterol - and possibly effective for helping with osteoarthritis, hardening of your arteries, heart attack risks, diabetes and cataracts. (meridia-nextday.org)
Liver damage and jaundice are risks with high doses of niacin. (swansonvitamins.com)
Avoid high doses of niacin if you have a liver or kidney disorder. (swansonvitamins.com)
If you notice other symptoms after high doses of niacin, you should consult a healthcare professional. (seekinghealth.com)
Larger than recommended doses of niacin have been associated with liver dysfunction. (vitalnutrientspro.co)
The human volunteers (aged 35-48) who took part in the study were given regular doses of niacin (500mg). (slimmersweekly.com)
Higher doses of niacin (3000 mg/day) reduce LDL cholesterol 15 to 20% but may cause jaundice, abdominal discomfort, blurred vision, worsening of hyperglycemia, and precipitation of preexisting gout. (msdmanuals.com)

tell your doctor and pharmacist if you are allergic to niacin, any other medications, or any of the ingredients in niacin tablets. (medlineplus.gov)
Consistent with this conclusion, the FDA has determined that the benefits of niacin ER tablets and fenofibric-acid [delayed-release] capsules for coadministration with statins no longer outweigh the risks, and the approvals for this indication should be withdrawn," a document filed in the Federal Registry today states [ 1 ] . (medscape.com)
Life Extension Mix Tablets With Extra Niacin products are reviewed below. (bestpricenutrition.com)
Vital Nutrients Niacin 500mg Extended Release Tablets contain a time-release matrix that slowly secretes niacin into the body. (vitalnutrientspro.co)

Before you choose which treatment method is right for you, you need to consider the benefits of niacin. (nutralegacy.com)
According to the studies, the benefits of niacin also include increasing levels of HDL , also known as good cholesterol, and providing results superior to those of some prescriptions. (nutralegacy.com)
It provides niacin in a low-flush form that enables you to enjoy the health benefits of niacin without experiencing the uncomfortable skin flushing. (swansonvitamins.com)
A niacin flush is actually a sign that your body is getting the benefits of niacin! (seekinghealth.com)

Nicotinamide is recommended as a treatment for niacin deficiency because it can be administered in remedial amounts without causing the flushing, considered an adverse effect. (wikipedia.org)
As the precursor for nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate, niacin is involved in DNA repair. (wikipedia.org)
Immediate- and sustained-release preparations of niacin (but not nicotinamide) may affect lipid levels. (msdmanuals.com)

Therefore, it is important to investigate the appropriate dietary supplementation of niacin in aquatic animals for optimum growth and feed utilization. (hindawi.com)
When taken on an empty stomach, a healthy response to niacin supplementation may include mild blushing, warming, or tingling of the skin. (seekinghealth.com)
Supplementation with niacin also ensure the blood circulates something else of value-human growth hormone (HGH). (dietpillbuyer.com)

For more details about the effects of statins given with high-dose niacin, see the Niacin section of the B Vitamins Product Review (which includes our tests of niacin and other B vitamins) . (consumerlab.com)
Deficiencies of protein and many B vitamins commonly accompany primary niacin deficiency. (merckmanuals.com)
But eating a well-balanced diet containing plenty of niacin and other B vitamins as part of a reduced-calorie meal plan gives you the best chance at successfully shedding pounds. (meridia-nextday.org)
Niacin and other B vitamins help your body produce energy from the foods you eat. (meridia-nextday.org)
Life Extension Mix TABS with Extra Niacin contains a wide variety of vitamins and nutrients to promote optimal health This formula includes Niacin which works with other B Vitamins to release energy from carbohydrates. (bestpricenutrition.com)
Niacin Max is a unique product that delivers an abundance of vitamins through a tiny strip that you place on your tongue. (slimmersweekly.com)

Niacin is often available with supplements. (nutralegacy.com)
While many supplements have not been proven effective in producing health results, this is not the case with niacin. (nutralegacy.com)
Another difference between niacin supplements and prescription cholesterol medication are the side effects. (nutralegacy.com)
Niacin supplements are widely available, and although they may not directly cause weight loss , they can provide you with health benefits during your weight loss regimen. (meridia-nextday.org)
But taking niacin supplements does not cause weight loss. (meridia-nextday.org)
It can also happen if you don't take niacin-containing supplements with food. (seekinghealth.com)
For example, if you take niacin as a standalone supplement or in a B-complex form along with other niacin supplements, you may experience a niacin flush. (seekinghealth.com)

A deficiency of niacin can be caused by inadequate dietary intake of niacin or inadequate intake of the amino acid tryptophan, which can be converted into niacin, although the conversion rate is low (Hidgon 2002). (newworldencyclopedia.org)
Inadequate intake of niacin may lead to several deficiency symptoms in crustaceans, such as anorexia and aversion to feed. (hindawi.com)
Meanwhile, excessive niacin intake has been reported to negatively affect the feed utilization and growth performance of juvenile grass shrimp ( Penaeus monodon ) and Pacific white shrimp ( Litopenaeus vannamei ) [ 3 , 4 ]. (hindawi.com)
Because of this high turnover, it's best to have a steady intake in niacin-rich foods. (foodnetwork.com)
Primary niacin deficiency results from extremely inadequate intake of both niacin and tryptophan , which usually occurs in areas where maize (Indian corn) constitutes a substantial part of the diet. (merckmanuals.com)
High dietary niacin intake is associated with decreased. (cambridge.org)
We observed a significant inverse association between translocation frequency and dietary intake of niacin ( P = 0·02): adjusted rate ratio for subjects in the highest tertile compared with the lowest tertile was 0·58 (95 % CI 0·40, 0·83). (cambridge.org)
Our data suggest that a high intake of niacin from food or a diet high in whole grains but low in red and processed meat may protect against cumulative DNA damage in IR-exposed persons. (cambridge.org)
His intake is 1-2 caps of Niacin (as inositol hexanicotinate 625mg) 500 mg. (curezone.org)

Important side effects of niacin include flushing, nausea and fainting. (nih.gov)

Despite the proven lipid changes, niacin has not been found useful for decreasing the risk of cardiovascular disease in those already on a statin. (wikipedia.org)
A 2010 review had concluded that niacin was effective as a mono-therapy, but a 2017 review incorporating twice as many trials concluded that prescription niacin, while affecting lipid levels, did not reduce all-cause mortality, cardiovascular mortality, myocardial infarctions, nor fatal or non-fatal strokes. (wikipedia.org)
Niacin has a very long history of clinical use in supporting cardiovascular health and has been shown to support lipid metabolism, Cholesterol, LDL, Lipoprotein (a) and HDL. (vitalnutrientspro.co)

Niacin Flush: Harmful or Helpful? (seekinghealth.com)
In this article, you'll learn more about the niacin flush, its benefits, what to do if it happens, and how to prevent it. (seekinghealth.com)
What is the Niacin Flush? (seekinghealth.com)
A niacin flush is not usually caused by the small amount of niacin found in most multivitamins. (seekinghealth.com)
However, if you take additional niacin, you may be more likely to experience a niacin flush. (seekinghealth.com)
However, many do not understand what causes niacin flush or that it is harmless. (seekinghealth.com)
What Does the Niacin Flush Feel Like? (seekinghealth.com)
A niacin flush can happen quickly - within five minutes of taking niacin - or may not appear for 15-45 minutes. (seekinghealth.com)
But a niacin flush is neither of these things. (seekinghealth.com)
Researchers have worked to create "no-flush" niacin or extended-release versions, but that comes at a price. (seekinghealth.com)
Even though niacin flush is uncomfortable, it is a sign of this nutrient's benefits! (seekinghealth.com)
Even if you flush when you first start taking it, it may not always happen when you supplement with niacin. (seekinghealth.com)
Is Niacin Flush Dangerous? (seekinghealth.com)

Do not stop taking niacin without talking to your doctor. (medlineplus.gov)
If you become pregnant while taking niacin, stop taking niacin and call your doctor. (medlineplus.gov)
This is the main reason that people stop taking niacin. (seekinghealth.com)

Several studies show the HGH boosting abilities of niacin can be further improved by using it during periods of hard exercise. (slimmersweekly.com)
That is certainly a respectable increase, but the results of a study published in Hormones & Behaviour reveal the HGH boosting abilities of niacin are enhanced when the supplement is taken within a few hours of training. (dietpillbuyer.com)

They found no significant association between niacin dose and phosphorus level. (renalandurologynews.com)
To investigate nicotinamide's action on glucose metabolism, and the association between niacin consumption and obesity prevalence. (wjgnet.com)

Results of a clinical study in people with heart disease and well-controlled cholesterol levels that compared people who took niacin and simvastatin with people who took simvastatin alone and found similar results for the two groups in the rate of heart attacks or strokes. (medlineplus.gov)
Niacin has been shown to reduce LDL cholesterol levels by up to 30% and that's for a standard dose. (nutralegacy.com)
If I already take red yeast rice, would adding high-dose niacin help further reduce my cholesterol levels, and would this be safe? (consumerlab.com)

NAD (and niacin) may also be synthesized in the liver from the amino acid tryptophan (Hidgon 2002). (newworldencyclopedia.org)
Tryptophan, which is found in turkey and some dairy products, is converted into niacin in the body. (nutralegacy.com)
The amino acid tryptophan, present in protein-rich foods like red meat, poultry, turkey, dairy products and eggs, can also be converted to niacin. (kingsoopers.com)

You can find niacin in many of the foods you consume, including fish, green vegetables, and grains. (nutralegacy.com)
Thankfully, you can find niacin in a wide variety of foods (see below). (foodnetwork.com)

Take niacin exactly as directed. (medlineplus.gov)
Continue to take niacin even if you feel well. (medlineplus.gov)

Foodborne illness associated with niacin: report of an outbreak linked to excessive niacin in enriched cornmeal. (cdc.gov)

Furthermore, many niacin-rich foods help with weight loss because they provide other nutrients, such as protein and fiber, that aid in healthy weight management. (meridia-nextday.org)
Clinical trials have demonstrated bioavailability and tolerance of Vital Nutrients extended release Niacin. (vitalnutrientspro.co)

Having played straightforward hard rock with Mr. Big since the tail end of the '80s, bass virtuoso Billy Sheehan formed Niacin as an outlet for his jazz fusion and prog rock inclinations during the mid-'90s. (allmusic.com)
Niacin must have been quite a learning experience for its bassist Billy Sheehan , whose main pre-Niacin gig had been his hard rock band Mr. Big . (allmusic.com)

Niacin as a dietary supplement is used to treat pellagra, a disease caused by niacin deficiency. (wikipedia.org)
Severe deficiency of niacin in the diet causes the disease pellagra, characterized by diarrhea, sun-sensitive dermatitis involving hyperpigmentation and thickening of the skin (see image), inflammation of the mouth and tongue, delirium, dementia, and if left untreated, death. (wikipedia.org)
Niacin is also used to prevent and treat pellagra (niacin deficiency), a disease caused by inadequate diet and other medical problems. (medlineplus.gov)
Niacin deficiency results in pellagra , reflecting the need for good and varied nutrition . (newworldencyclopedia.org)
Severe lack of niacin causes the deficiency disease pellagra , whereas a mild deficiency slows down the metabolism decreasing cold tolerance. (newworldencyclopedia.org)
Dietary niacin deficiency (causing pellagra) is uncommon in countries with low rates of food insecurity. (merckmanuals.com)

I stopped taking niacin because I get some pretty bad rashes, like an allergic reaction, when I take it. (uexpress.com)
DEAR S.T.: It is doubtful that it's niacin, an essential nutrient, that you are allergic to. (uexpress.com)
Niacin acts as a vasodilator, and the flushing and tingling sensation it creates is often mistaken for an allergic reaction. (kingsoopers.com)

Your doctor will probably start you on a low dose of niacin and gradually increase your dose. (medlineplus.gov)
If you take insulin or oral diabetes medication, your dose may need to be changed because niacin may increase the amount of sugar in your blood and urine. (medlineplus.gov)
If so, then what is the recommended dose for niacin? (nutralegacy.com)
However, studies in which statin drugs have been given with high-dose niacin therapy suggest that this is not a helpful combination for most people and there are safety concerns. (consumerlab.com)
The same issues are likely to arise with the combination of red yeast rice and high-dose niacin therapy, so this combination should be carefully evaluated. (consumerlab.com)
The patients were on niacin-ER daily for 59 months, on average, at a median dose of 2,250 mg. (medicalxpress.com)
This could be seen as a cruel trick on Mother Nature's part, but she also appears to have provided a solution to the problem because a potent dose of niacin can stimulate the release of extra HGH. (dietpillbuyer.com)
The chance of severe flushing can be reduced by starting immediate-release niacin at a low dose (eg, 50 mg 3 times a day) and increasing it very slowly. (msdmanuals.com)
Some authorities recommend checking levels of uric acid, blood glucose, and plasma aminotransferases every 6 to 8 weeks until the dose of niacin has been stabilized. (msdmanuals.com)

The recommended daily allowance of niacin is 2-12 milligrams a day for children, 14 milligrams a day for women, 16 milligrams a day for men, and 18 milligrams a day for pregnant or breast-feeding women (Higdon 2002). (newworldencyclopedia.org)
Niacin needs are higher in men and breastfeeding women, at 16 milligrams and 18 milligrams daily for each. (healthycholesterolclub.com)

Niacin is obtained in the diet from a variety of whole and processed foods, with highest contents in fortified packaged foods, meat, poultry, red fish such as tuna and salmon, lesser amounts in nuts, legumes and seeds. (wikipedia.org)
Many foods rich in niacin - such as lean meats, poultry, dairy foods, fish, legumes, eggs, nuts and enriched whole-grain cereals - are beneficial when you're trying to lose weight. (meridia-nextday.org)
Fiber present in niacin-rich legumes, nuts and whole grains also boosts satiety and helps enhance weight loss. (meridia-nextday.org)

SILVER SPRING, MD - Citing a lack of cardiovascular benefit, the FDA is taking the unusual step of withdrawing approvals it had previously given for use of niacin and fenofibric acid with statins to treat high cholesterol [ 1 ] . (medscape.com)
The four-year study tested a combination of extended-release (ER) niacin with laropiprant in patients at risk for cardiovascular problems such as heart disease and stroke. (acc.org)
In 2011, AIM-HIGH was halted early when researchers determined a lack of effect for niacin in reducing cardiovascular events. (acc.org)
Niacin promotes cardiovascular health, and plays an important role in metabolism and energy production within the body. (swansonvitamins.com)

The 25,673 patients in the study were randomized to receive ER niacin/laropiprant 2g/40mg or a placebo, and all received commonly prescribed LDL cholesterol-lowering medication simvastatin (with or without ezetimibe). (acc.org)
Patients receiving ER niacin/laropiprant had a similar number of major vascular events as patients receiving placebo (13.2 vs. 13.7 percent, p=0.29). (acc.org)
The study also found unexpected and significant excesses of bleeding (2.5 vs. 1.9 percent) and infections (8.0 vs. 6.6 percent) among the ER niacin/laropiprant patients. (acc.org)
Laropiprant was added to reduce the facial flushing caused by niacin. (acc.org)
While there was some speculation that the trial's results may have been due to unexpected side effects of laropiprant, Dr. Armitage believes this is unlikely, as the lack of benefit on heart attacks and strokes is consistent with the recent AIM-HIGH study, which did not use laropiprant, and many of the side effects are known to be due to niacin. (acc.org)
ER niacin/laropiprant has been approved in 70 countries and was being sold in 40. (acc.org)
The Food and Drug Administration was awaiting results from HPS2-THRIVE to license the drug in the U.S. In response to preliminary findings, the drug manufacturer Merck announced in December 2012 that it no longer planned to take the drug before the FDA for approval and in January suspended ER niacin/laropiprant from markets worldwide. (acc.org)

Symptoms of a mild deficiency of niacin include fatigue and indigestion. (kingsoopers.com)
Eleven of 13 niacin workers reported skin symptoms. (cdc.gov)

The decision affects the indication of niacin extended-release ( Niaspan , AbbVie) and fenofibric acid ( Trilipix , AbbVie), as well as AbbVie's Advicor and Simcor , both of which combine niacin with a statin. (medscape.com)

Taking niacin along with simvastatin or lovastatin also has not been shown to reduce the risk of heart disease or death compared with the use of niacin, simvastatin, or lovastatin alone. (medlineplus.gov)
The same reasoning was cited for pulling its approval of Advicor (niacin extended-release/lovastatin) and Simcor (niacin extended-release/simvastatin) [ 2 ] . (medscape.com)

This harmless reaction can occur if you take more niacin than your body is used to taking. (seekinghealth.com)

With niacin, you might experience a flushed face, chills, or tingling shortly after taking the supplement. (nutralegacy.com)
We quickly corrected it with niacin rich foods and adding a niacin supplement to their food. (backyardchickens.com)
As many as one-fifth of people who supplement with niacin end up stopping because of the flushing side effect. (seekinghealth.com)
Lindberg's Niacin supplement makes it super convenient to get daily support. (pipingrock.com)
As a bodybuilding aid and sports supplement, niacin has a lot to offer. (slimmersweekly.com)
Niacin boosts red blood cell production, so people supplementing with a quality niacin-providing supplement are unlikely to have this issue to contend with. (dietpillbuyer.com)

There are two forms: immediate-release and sustained-release niacin. (wikipedia.org)

However, niacin boasts another ability that is not so well known-it boosts production of human growth hormone (HGH). (slimmersweekly.com)

Patients taking niacin preparations to prevent heart disease should consider talking with their health care providers to determine whether the therapy is appropriate to continue. (acc.org)

Periodic liver function testing and supervision of the qualified healthcare professional are strongly recommended with niacin dosing in excess of 500 mg daily. (bestpricenutrition.com)

Niacin comes as a tablet and an extended-release (long-acting) tablet to take by mouth. (medlineplus.gov)
Nature's Blend Niacin delivers 500 mg in each tablet. (swansonvitamins.com)

In its coenzyme forms, niacin is crucial to energy transfer reactions related to fat, alcohol and glucose. (kingsoopers.com)

if you are taking a bile acid-binding resin such as colestipol (Colestid) or cholestyramine (Questran), take it at least 4 to 6 hours before or 4 to 6 hours after niacin. (medlineplus.gov)
The conversion of niacin to NAD and NADP, and the use of these coenzymes in intricate biological processes like the citric acid cycle, reveals the complex coordination in living organisms. (newworldencyclopedia.org)

Diseases3

Chemicals and Drugs7

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Effects of fatty acids and ketone bodies on basal insulin secretion in type 2 diabetes. (1/572)

Niacin accelerates intracellular ApoB degradation by inhibiting triacylglycerol synthesis in human hepatoblastoma (HepG2) cells. (2/572)

Evidence for a new pathophysiological mechanism for coronary artery disease regression: hepatic lipase-mediated changes in LDL density. (3/572)

The protein phosphatase inhibitor cantharidin induces head and foot formation in buds of Cassiopea andromeda (Rhizostomae, Scyphozoa). (4/572)

Inhibitors of poly (ADP-ribose) synthetase protect rat cardiomyocytes against oxidant stress. (5/572)

Effect of mutagenesis at serine 653 of Arabidopsis thaliana acetohydroxyacid synthase on the sensitivity to imidazolinone and sulfonylurea herbicides. (6/572)

The effects of acute nicotine on the metabolism of dopamine and the expression of Fos protein in striatal and limbic brain areas of rats during chronic nicotine infusion and its withdrawal. (7/572)

Gemfibrozil, nicotinic acid and combination therapy in patients with isolated hypoalphalipoproteinemia: a randomized, open-label, crossover study. (8/572)

Niacin

Flushing

Pellagra

Hypolipidemic Agents

Nicotinic Acids

Niacinamide

Vitamin B Complex

Delayed-Action Preparations

Vitamin B Deficiency

Xanthurenates

Effects of fatty acids and ketone bodies on basal insulin secretion in type 2 diabetes. (1/572)

Niacin accelerates intracellular ApoB degradation by inhibiting triacylglycerol synthesis in human hepatoblastoma (HepG2) cells. (2/572)

Evidence for a new pathophysiological mechanism for coronary artery disease regression: hepatic lipase-mediated changes in LDL density. (3/572)

The protein phosphatase inhibitor cantharidin induces head and foot formation in buds of Cassiopea andromeda (Rhizostomae, Scyphozoa). (4/572)

Inhibitors of poly (ADP-ribose) synthetase protect rat cardiomyocytes against oxidant stress. (5/572)

Effect of mutagenesis at serine 653 of Arabidopsis thaliana acetohydroxyacid synthase on the sensitivity to imidazolinone and sulfonylurea herbicides. (6/572)

The effects of acute nicotine on the metabolism of dopamine and the expression of Fos protein in striatal and limbic brain areas of rats during chronic nicotine infusion and its withdrawal. (7/572)

Gemfibrozil, nicotinic acid and combination therapy in patients with isolated hypoalphalipoproteinemia: a randomized, open-label, crossover study. (8/572)

Niacin

Niacin receptor

Niacin (disambiguation)

Niacin test

Deep (Niacin album)

List of jazz fusion musicians

Orthomolecular medicine

Vitamin deficiency

Billy Sheehan

Nicotinamide adenine dinucleotide

Uncle Sam (cereal)

B vitamins

Nicotinamide

Menthyl nicotinate

Nicotinyl methylamide

Abram Hoffer

Food fortification

Sardine

Achlorhydria

List of dopaminergic drugs

Francisco Xavier de Mendonça Furtado

Dementia

Okara (food)

Acifran

Timeline of United States discoveries

Nipecotic acid

Megavitamin therapy

GeneMatcher

Maize

Pyridine

Niacin - Wikipedia

Niacin: MedlinePlus Drug Information

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