Nigella sativa
Benzoquinones
Nigella damascena
Plant Extracts
Hemidesmus
Oryza sativa
Smilax
Lepidium sativum
Seeds
Urtica dioica
Oils, Volatile
Partial regeneration/proliferation of the beta-cells in the islets of Langerhans by Nigella sativa L. in streptozotocin-induced diabetic rats. (1/55)
This experiment was carried out to investigate the effect of N. sativa L. on histopathology of pancreatic beta-cells, and blood insulin and glucose concentrations in streptozotocin-induced diabetic rats. Fifty male Wistar rats (200-250 g) were divided into two experimental groups (diabetics with no treatment and diabetics with N. sativa L. treatment), each containing twenty-five rats. Diabetes was induced in both groups by a single intraperitoneal injection of streptozotocin (STZ) (50 mg/kg). The experimental animals in both groups became diabetic within 24 hours after the administration of STZ. The rats in N. sativa L.-treated group were given the daily intraperitoneal injection of 0.20 ml/kg of N. sativa L. volatile oil for 30 days starting the day after STZ injection. Control rats received only the same amount of normal saline solution. The rats in both groups received the last injection 24 hours before the sacrification and 5 randomly-selected rats in each group were sacrificed before, and the 1, 10, 20 and 30 days after the STZ injection to collect blood and pancreatic tissue samples. The N. sativa L. treatment caused a decrease in the elevated serum glucose, an increase in the lowered serum insulin concentrations and partial regeneration/ proliferation of pancreatic beta-cells in STZ-induced diabetic rats with the elapse of the experiment. It is concluded that the hypoglycaemic action of N. sativa L. could be partly due to amelioration in the beta-cells of pancreatic islets causing an increase in insulin secretion. More studies are needed to demonstrate the exact mechanism of action of N. sativa L. on ameliorated blood glucose concentration in STZ-induced diabetes. (+info)Possible mechanism(s) for relaxant effect of aqueous and macerated extracts from Nigella sativa on tracheal chains of guinea pig. (2/55)
BACKGROUND: In previous studies, the relaxant, anticholinergic (functional antagonism) and antihistaminic effects of Nigella sativa have been demonstrated on guinea pig tracheal chains. To elucidate the other mechanisms responsible for the relaxant effect of this plant, its inhibitory effect on the calcium channel was examined in this study. RESULTS: The inhibitory effects of both concentrations of diltiazem in all three groups of experiments were significantly greater than those of saline (p < 0.01 to P < 0.001). The inhibitory of two larger concentrations of aqueous extracts in group 1 and 2 were significantly greater than those of saline (p < 0.01 to P < 0.001). The effect of two larger concentrations of macerated extract in group 1 and all concentrations of this extract in group 2 were also significantly greater than those of saline (p < 0.01 to P < 0.001). However, the extract of Nigella sativa did not show any inhibitory effect in group 3. There was a significant correlation between inhibitory effect and increasing concentrations for both extracts and diltiazem in groups 1 and 2 (p < 0.05 to p < 0.005). CONCLUSION: Although the extracts of Nigella sativa showed inhibitory effects on pre-contracted tracheal chains in the presence of both ordinary and calcium free Krebs solution, the absence of inhibitory effects of the extracts on KCl induced contraction of tracheal chains suggest that the calcium channel blocking effect of this plant dose not contribute to the relaxant effect of this plant on the tracheal chains of guinea pigs. (+info)Effects of Nigella sativa on oxidative stress and beta-cell damage in streptozotocin-induced diabetic rats. (3/55)
The aim of the present study was to evaluate the possible protective effects of Nigella sativa L. (NS) against beta-cell damage from streptozotocin (STZ)-induced diabetes in rats. STZ was injected intraperitoneally at a single dose of 50 mg/kg to induce diabetes. NS (0.2 ml/kg/day, i.p.) was injected for 3 days prior to STZ administration, and these injections were continued throughout the 4-week study. Oxidative stress is believed to play a role in the pathogenesis of diabetes mellitus (DM). To assess changes in the cellular antioxidant defense system, we measured the activities of antioxidant enzymes (such as glutathione peroxidase (GSHPx), superoxide dismutase (SOD), and catalase (CAT)) in pancreatic homogenates. We also measured serum nitric oxide (NO) and erythrocyte and pancreatic tissue malondialdehyde (MDA) levels, a marker of lipid peroxidation, to determine whether there is an imbalance between oxidant and antioxidant status. Pancreatic beta-cells were examined by immunohistochemical methods. STZ induced a significant increase in lipid peroxidation and serum NO concentrations, and decreased antioxidant enzyme activity. NS treatment has been shown to provide a protective effect by decreasing lipid peroxidation and serum NO, and increasing antioxidant enzyme activity. Islet cell degeneration and weak insulin immunohistochemical staining was observed in rats with STZ-induced diabetes. Increased intensity of staining for insulin, and preservation of beta-cell numbers were apparent in the NS-treated diabetic rats. These findings suggest that NS treatment exerts a therapeutic protective effect in diabetes by decreasing oxidative stress and preserving pancreatic beta-cell integrity. Consequently, NS may be clinically useful for protecting beta-cells against oxidative stress. (+info)Effects of alpha-hederin and thymoquinone, constituents of Nigella sativa, on human cancer cell lines. (4/55)
The separate effects of alpha-hederin and thymoquinone, the two principal bioactive constituents of Nigella sativa, on four human cancer cell lines [A549 (lung carcinoma), HEp-2 (larynx epidermoid carcinoma), HT-29 (colon adenocarcinoma) and MIA PaCa-2 (pancreas carcinoma)] were investigated. Alpha-hederin was also examined as a pro-drug. Each assessment quantified both cytotoxic and apoptotic/necrotic effects. Alpha-hederin and thymoquinone separately induced a dose- and time-dependent effect on the cell lines tested. HEp-2 cells were the most sensitive, exhibiting apoptosis with a higher incidence following thymoquinone treatment. Pre-treatment of cells with alpha-hederin, followed by thymoquinone or cisplatin, did not enhance the cytotoxicity or apoptosis induced by either drug. So, the membrane-perforating properties associated with saponins, here represented by alpha-hederin, enhance neither cytotoxicity nor apoptosis of these cancer cells. (+info)Modes of action of alpha-hederin and thymoquinone, active constituents of Nigella sativa, against HEp-2 cancer cells. (5/55)
Our previous studies on active constituents of Nigella sativa have indicated that cell death induced by thymoquinone and alpha-hederin was dose- and time-dependent, in a range of four cancer cell lines. Both compounds elicited necrosis and apoptosis with a higher incidence of the latter induced by thymoquinone. As HEp-2 human laryngeal carcinoma cells were the most susceptible, we sought to better understand the mechanisms involved by using buthionine sulfoximine (BSO), a selective inhibitor of glutathione (GSH) synthesis, to determine the importance of GSH in the apoptosis elicited, using cisplatin as internal standard. BSO significantly enhanced alpha-hederin- and cisplatin- mediated toxicity as assessed by the MIT assay, without changes in apoptosis or necrosis levels. Although the MTI assay did not indicate BSO potentiation of thymoquinone, apoptosis levels were significantly enhanced following this combination, without changes in necrosis. Thymoquinone and cisplatin significantly decreased GSH levels in a dose-dependent manner, with BSO pre-treatment synergistically depleting GSH levels in only thymoquinone- treated cells. As the caspase 3 inhibitor, Z-DEVD-fmk significantly decreased thymoquinone- and cisplatin-induced apoptosis, GSH depletion and caspase 3-activation mediate thymoquinone-induced apoptosis, in this cell line. (+info)The biochemical and morphological alterations following administration of melatonin, retinoic acid and Nigella sativa in mammary carcinoma: an animal model. (6/55)
Worldwide, breast cancer is the second leading cause of cancer death among women and the third most common cancer. Although our understanding of the molecular basis of this fatal disease has improved, this malignancy remains elusive. Melatonin (Mel), retinoic acid (RA) and Nigella sativa (NS) are substances with anticancer effects. To date, our understanding of the mechanisms of therapeutic effects of these products in mammary cancer is still marginal. To look at the preventive and therapeutic values of these products, we carried out this investigation. An animal model formed of 80 rats was established. The animals were divided into eight groups of 10 animals each: (a) control group injected with the same vehicle used for treatments in the relevant dosages and routes; (b) carcinogen group injected with the known carcinogenic substance 7,12-di-methylbenz(a)anthracene (DMBA) that induces mammary carcinoma; (c) three prophylactic (Pro) groups (Mel-Pro, RA-Pro and NS-Pro) injected with test substances (Mel, RA and NS, respectively) 14 days before the intake of the carcinogenic substance DMBA and then continued until the end of the experiments; and (d) three treated (Tr) groups (Mel-Tr, RA-Tr and NS-Tr) injected with the vehicles after the intake of DMBA. In both the Pro and Tr groups, the drugs were daily administered for 3 months. The animals were killed, and their serum and tissues were evaluated for (a) markers of tumorigenicity [serum levels of total sialic acid (TSA) and lipid-bound sialic acid (LSA)], (b) markers of endocrine derangement (serum prolactin, estradiol and progesterone levels), (c) apoptotic changes [serum tumour necrosis factor (TNF)-alpha, tissue caspase-3 activity, percentage of DNA fragmentation and ultrastructural features of apoptosis] and (d) markers of oxidative stress (tissue levels of lipid peroxides and nitric oxide). Carcinoma was absent both in the control and in the NS-Pro groups. Mammary carcinoma occurred in DMBA and other Pro and Tr groups. The frequency of mammary carcinoma was high in the carcinogen DMBA group (60%), followed by the Tr (56%) and finally the Pro groups (33%). These tumours included papillary, comedo and cribriform carcinomas. As compared with the control group, the development of carcinoma in the carcinogen DMBA group was associated with increased levels of (a) markers of tumorigenicity (77.0 +/- 3.3 vs. 209.0 +/- 5.6 and P < 0.05 for TSA; 28.7 +/- 1.7 vs. 41.8 +/- 1.2 and P < 0.01 for LSA), (b) markers of endocrine derangement (2.5 +/- 0.1 vs. 3.6 +/- 0.3 and P < 0.05 for prolactin; 39.6 +/- 1.3 vs. 24.8 +/- 2.1 and P < 0.01 for progesterone and 31.0 +/- 0.7 vs. 51.1 +/- 3.4 and P < 0.01 for estradiol) and (c) markers of oxidative stress (2.3 +/- 0.2 vs. 5.2 +/- 0.7 and P < 0.01 for lipid peroxides and 4.4 +/- 0.2 vs. 7.6 +/- 0.8 and P < 0.01 for nitric oxide). Also, it was associated with decreased levels of markers of apoptotic activity (20.8 +/- 1.1 vs. 13.4 +/- 0.7 and P < 0.01 for caspase-3; 29.0 +/- 1.7 vs. 20.9 +/- 1.3 and P < 0.05 for percentage of DNA fragmentation; and 9.4 +/- 0.8 vs. 52.1 +/- 3.3 and P < 0.01 for TNF-alpha). When compared with the carcinogen DMBA group, the development of carcinoma in the Pro and Tr groups was associated with decreased levels of (a) markers of tumorigenicity, (b) markers of endocrine derangement and (c) markers of oxidative stress. Alternatively, carcinogenicity was associated with statistically significant (P < 0.01) increased levels of markers of apoptotic activity. To conclude, the administration of Mel, RA and NS reduced the carcinogenic effects of DMBA, suggesting a protective role. The possible underlying mechanisms of these effects await further investigations. (+info)Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats. (7/55)
AIM: To investigate the effects of Nigella sativa L (NS) and Urtica dioica L (UD) on lipid peroxidation, antioxidant enzyme systems and liver enzymes in CCl(4)-treated rats. METHODS: Fifty-six healthy male Wistar albino rats were used in this study. The rats were randomly allotted into one of the four experimental groups: A (CCl(4)-only treated), B (CCl(4)+UD treated), C (CCl(4)+NS treated) and D (CCl(4)+UD+NS treated), each containing 14 animals. All groups received CCl(4) (0.8 mL/kg of body weight, sc, twice a week for 60 d). In addition, B, C and D groups also received daily i.p. injections of 0.2 mL/kg NS or/and 2 mL/kg UD oils for 60 d. Group A, on the other hand, received only 2 mL/kg normal saline solution for 60 d. Blood samples for the biochemical analysis were taken by cardiac puncture from randomly chosen-seven rats in each treatment group at beginning and on the 60th d of the experiment. RESULTS: The CCl(4) treatment for 60 d increased the lipid peroxidation and liver enzymes, and also decreased the antioxidant enzyme levels. NS or UD treatment (alone or combination) for 60 d decreased the elevated lipid peroxidation and liver enzyme levels and also increased the reduced antioxidant enzyme levels. The weight of rats decreased in group A, and increased in groups B, C and D. CONCLUSION: NS and UD decrease the lipid per-oxidation and liver enzymes, and increase the anti-oxidant defense system activity in the CCl4-treated rats. (+info)Effects of essential oil extracted from Nigella sativa (L.) seeds and its main components on human neutrophil elastase activity. (8/55)
The effects of essential oil extracted from Nigella sativa (L.) seeds and its main components on human neutrophil elastase (HNE) activity were investigated. Essential oil was extracted from N. sativa (L.) seeds using hydrodistillation. The yield was equal to 0.4%. Inhibition of HNE activity by essential oil was found to be dose dependent. The highest inhibitory concentration (HIC) of essential oil which caused total inhibition of HNE activity was 5.8 mg/ml. Microassays carried out to evaluate the inhibitory effect of major components of essential oil on HNE activity revealed that carvacrol (5-isopropyl-2-methylphenol) showed marked HNE inhibitory activity with a very low IC(50) value (12 microM). Based on these results, the inhibitory effects of essential oil on HNE activity are due to the presence of bioactive molecules, mainly carvacrol this compound is an inhibitor of HNE and could be considered as a natural antielastase agent and possible candidate for phytotherapy in the treatment of injuries that appear in some pathologic cases such as chronic obstructive pulmonary disease and emphysema. (+info)"Nigella sativa," also known as black cumin, is not a medical term but a botanical name for a plant that has been used in traditional medicine. The seeds of this plant are used as a spice and have been used in various traditional medicinal systems for their potential health benefits. However, it's important to note that while some studies suggest possible health benefits, more research is needed before any definitive medical claims can be made.
The seeds contain thymoquinone, which has been studied for its antioxidant, anti-inflammatory, and potential anticancer properties. However, these studies have primarily been conducted in vitro or on animals, and more research is needed to determine the safety and efficacy of Nigella sativa in humans for these purposes.
Therefore, it's always recommended to consult with a healthcare professional before starting any new supplement regimen, including the use of Nigella sativa seeds or oil.
"Nigella" is a term that refers to the seeds or oil derived from the Nigella sativa plant, also known as black cumin or fennel flower. The seeds and oil have been used in traditional medicine for various health purposes, such as treating digestive issues, respiratory conditions, and headaches. However, it is important to note that while some studies suggest potential health benefits of Nigella, more research is needed to confirm its effectiveness and safety.
Phytotherapy is the use of extracts of natural origin, especially plants or plant parts, for therapeutic purposes. It is also known as herbal medicine and is a traditional practice in many cultures. The active compounds in these plant extracts are believed to have various medicinal properties, such as anti-inflammatory, analgesic, or sedative effects. Practitioners of phytotherapy may use the whole plant, dried parts, or concentrated extracts to prepare teas, capsules, tinctures, or ointments for therapeutic use. It is important to note that the effectiveness and safety of phytotherapy are not always supported by scientific evidence, and it should be used with caution and preferably under the guidance of a healthcare professional.
Benzoquinones are a type of chemical compound that contain a benzene ring (a cyclic arrangement of six carbon atoms) with two ketone functional groups (-C=O) in the 1,4-positions. They exist in two stable forms, namely ortho-benzoquinone and para-benzoquinone, depending on the orientation of the ketone groups relative to each other.
Benzoquinones are important intermediates in various biological processes and are also used in industrial applications such as dyes, pigments, and pharmaceuticals. They can be produced synthetically or obtained naturally from certain plants and microorganisms.
In the medical field, benzoquinones have been studied for their potential therapeutic effects, particularly in the treatment of cancer and infectious diseases. However, they are also known to exhibit toxicity and may cause adverse reactions in some individuals. Therefore, further research is needed to fully understand their mechanisms of action and potential risks before they can be safely used as drugs or therapies.
'Nigella damascena' is not a medical term. It is the scientific name for a plant species that is commonly known as Love-in-a-Mist. Love-in-a-Mist is an ornamental flowering plant native to southern Europe and western Asia. The seeds of this plant are sometimes used in cooking and have been used in traditional medicine, although there is limited scientific evidence supporting their effectiveness for medicinal purposes.
A plant extract is a preparation containing chemical constituents that have been extracted from a plant using a solvent. The resulting extract may contain a single compound or a mixture of several compounds, depending on the extraction process and the specific plant material used. These extracts are often used in various industries including pharmaceuticals, nutraceuticals, cosmetics, and food and beverage, due to their potential therapeutic or beneficial properties. The composition of plant extracts can vary widely, and it is important to ensure their quality, safety, and efficacy before use in any application.
Medical definitions generally do not include plant oils as a specific term. However, in a biological or biochemical context, plant oils, also known as vegetable oils, are defined as lipid extracts derived from various parts of plants such as seeds, fruits, and leaves. They mainly consist of triglycerides, which are esters of glycerol and three fatty acids. The composition of fatty acids can vary between different plant sources, leading to a range of physical and chemical properties that make plant oils useful for various applications in the pharmaceutical, cosmetic, and food industries. Some common examples of plant oils include olive oil, coconut oil, sunflower oil, and jojoba oil.
"Hemidesmus" is a botanical term that refers to a plant species, rather than a medical condition or concept. The plant is known as Hemidesmus indicus, or Indian sarsaparilla, and it has been used in traditional Ayurvedic medicine for various health purposes such as treating skin diseases, rheumatism, and digestive issues.
The roots of the Hemidesmus indicus plant contain several chemical compounds with potential medicinal properties, including steroidal saponins, alkaloids, and phenolic compounds. However, there is limited scientific evidence to support many of the traditional uses of this plant, and further research is needed to establish its safety and efficacy in modern medical practice.
"Oryza sativa" is the scientific name for Asian rice, which is a species of grass and one of the most important food crops in the world. It is a staple food for more than half of the global population, providing a significant source of calories and carbohydrates. There are several varieties of Oryza sativa, including indica and japonica, which differ in their genetic makeup, growth habits, and grain characteristics.
Oryza sativa is an annual plant that grows to a height of 1-2 meters and produces long slender leaves and clusters of flowers at the top of the stem. The grains are enclosed within a tough husk, which must be removed before consumption. Rice is typically grown in flooded fields or paddies, which provide the necessary moisture for germination and growth.
Rice is an important source of nutrition for people around the world, particularly in developing countries where it may be one of the few reliable sources of food. It is rich in carbohydrates, fiber, and various vitamins and minerals, including thiamin, riboflavin, niacin, iron, and magnesium. However, rice can also be a significant source of arsenic, a toxic heavy metal that can accumulate in the grain during growth.
In medical terms, Oryza sativa may be used as a component of nutritional interventions for individuals who are at risk of malnutrition or who have specific dietary needs. It may also be studied in clinical trials to evaluate its potential health benefits or risks.
"Smilax" is a genus of flowering plants, also known as greenbriars. While "Smilax" itself is not a medical term, some species of this plant have been used in traditional medicine. For instance, the roots and rhizomes of Smilax aristolochiifolia (Mexican sarsaparilla) and Smilax ornata (Jamaican sarsaparilla) have been used in traditional herbal remedies for various health conditions, including skin diseases, rheumatism, and sexual impotence. However, it's important to note that the scientific evidence supporting these uses is generally weak, and these remedies may carry risks, such as allergic reactions or contamination with harmful substances. Always consult a healthcare provider before starting any new treatment.
"Lepidium sativum" is the biological name for a plant species more commonly known as garden cress or pepperwort. While it is primarily used as a leaf vegetable, it has been utilized in traditional medicine in various cultures. However, it's important to note that describing 'Lepidium sativum' as a medical term isn't accurate. Medial definitions typically refer to diseases, conditions, symptoms, or procedures. 'Lepidium sativum' is a plant, and its medicinal uses would be described with terms referring to those specific applications.
In medical terms, "seeds" are often referred to as a small amount of a substance, such as a radioactive material or drug, that is inserted into a tissue or placed inside a capsule for the purpose of treating a medical condition. This can include procedures like brachytherapy, where seeds containing radioactive materials are used in the treatment of cancer to kill cancer cells and shrink tumors. Similarly, in some forms of drug delivery, seeds containing medication can be used to gradually release the drug into the body over an extended period of time.
It's important to note that "seeds" have different meanings and applications depending on the medical context. In other cases, "seeds" may simply refer to small particles or structures found in the body, such as those present in the eye's retina.
"Plant preparations" is not a term with a specific medical definition in the field of medicine or pharmacology. However, it is commonly used to refer to various forms of plant material that have been prepared for medicinal use. This can include dried and powdered plant parts, such as leaves, roots, or flowers, as well as extracts or concentrates made from plants. These preparations may be used in traditional medicine or as the basis for modern pharmaceuticals. It is important to note that the safety, effectiveness, and quality of plant preparations can vary widely, and they should only be used under the guidance of a qualified healthcare provider.
"Urtica dioica," also known as stinging nettle, is a plant species native to Europe, Asia, North Africa, and North America. While it doesn't have a formal medical definition, it is widely used in herbal medicine. The leaves and stems of the plant contain various compounds, including histamine, acetylcholine, serotonin, and forms of nitrogen like formic acid, which can cause a stinging sensation when they come into contact with human skin.
In medical contexts, Urtica dioica extracts are sometimes used to treat conditions such as allergies, joint pain, and urinary tract infections. However, it's important to note that the scientific evidence supporting these uses is generally limited, and more research is needed to confirm their effectiveness and safety. As with any medical treatment or supplement, individuals should consult with a healthcare provider before using Urtica dioica for therapeutic purposes.
Volatile oils, also known as essential oils, are a type of organic compound that are naturally produced in plants. They are called "volatile" because they evaporate quickly at room temperature due to their high vapor pressure. These oils are composed of complex mixtures of various compounds, including terpenes, terpenoids, aldehydes, ketones, esters, and alcohols. They are responsible for the characteristic aroma and flavor of many plants and are often used in perfumes, flavors, and aromatherapy. In a medical context, volatile oils may have therapeutic properties and be used in certain medications or treatments, but it's important to note that they can also cause adverse reactions if not used properly.
Methanol, also known as methyl alcohol or wood alcohol, is a volatile, colorless, flammable liquid with a distinctive odor similar to that of ethanol (drinking alcohol). It is used in various industrial applications such as the production of formaldehyde, acetic acid, and other chemicals. In the medical field, methanol is considered a toxic alcohol that can cause severe intoxication and metabolic disturbances when ingested or improperly consumed. Methanol poisoning can lead to neurological symptoms, blindness, and even death if not treated promptly and effectively.
Nigella sativa
Elwendia persica
Α-Hederin
Dithymoquinone
Evoca Cola
Thymol
Thomas Stephens Konknni Kendr
Nigella
Rhipicephalus annulatus
Thymoquinone
Flora of Nepal
Microangiopathy
Indazole
Outline of herbs and spices
Nigella arvensis
Anti-inflammatory
Ranunculaceae
Sativum
Damascenine
Nigella damascena
Carvacrol
Prophetic medicine
Plasmodium yoelii
Tresse cheese
Bint al-sahn
Libba
Black cumin
List of plants used in herbalism
Ka'ak
Qizha
Nigella sativa - Wikipedia
CIMB | Free Full-Text | Effect of Nigella sativa on Selected Gastrointestinal Diseases
Effect of Nigella sativa L. supplementation on inflammatory and oxidative stress indicators: A systematic review and meta...
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Seeds31
- Fruits Seeds Close-up of the seeds The seeds of N. sativa are used as a spice in many cuisines. (wikipedia.org)
- Archaeological evidence about the earliest cultivation of N. sativa dates back three millennia, with N. sativa seeds found in several sites from ancient Egypt, including the Tomb of Tutankhamun. (wikipedia.org)
- Oils are 32% to 40% of the total composition of N. sativa seeds. (wikipedia.org)
- Despite considerable use of N. sativa in traditional medicine practices in Africa and Asia, there is insufficient high-quality clinical evidence to indicate that consuming the seeds or oil can be used to treat human diseases. (wikipedia.org)
- Nigella Seeds: What the Heck Do I Do with Those? (wikipedia.org)
- Efficacy: history of use (previous disease & conditions) for antiviral and immunomodulatory effects of both Nigella sativa seeds and thymoquinone. (globinmed.com)
- Safety: toxicity studies, side effects and adverse effects if any for both Nigella sativa seeds and thymoquinone. (globinmed.com)
- Safety: Two human studies showed that Nigella sativa seeds are relatively safe at low doses, with a daily intake of 3g/day of seeds up to 3 months showing no serious adverse effects or organ toxicity. (globinmed.com)
- As for safety, animal studies reported N. sativa seeds are relatively safe at low doses, but the thymoquinone compound requires further evaluation. (globinmed.com)
- 1-liter glass bottle of the mild black seed oil formulated by our experts, at The Blessed Seed, in the purest way possible by cold pressing the best Nigella Sativa seeds. (theblessedseed.com)
- Nigella Seeds are truly a hidden gem. (spiceitupwithdeb.com)
- Nigella Seeds. (spiceitupwithdeb.com)
- Nigella sativa is one the most revered medicinal seeds in history. (richeria-grandis.com)
- Nigella sativa seeds have very little aroma but are carminative, meaning they tend to aid digestion and relieve gases in the stomach and intestines. (richeria-grandis.com)
- The seeds of Nigella Sativa are widely used in cooking and are also used in traditional herbal medicine and are believed to have a variety of health benefits. (gardenerstar.com)
- Black seed (also known as nigella seeds) is a member of the buttercup family and its seeds are dark, thin, and crescent shaped with approximately 100 nutritional chemical constituents present (new nutritional compounds are still being identified). (piekarnia-bochen.pl)
- Shanghai Herbary Supply Kalonji Oil Pure, Find Complete Details about Shanghai Herbary Supply Kalonji Oil Pure,Black Cumin Oil Extraction Machine,Kalonji Seeds Price,Nigella Seeds (kalonji Seeds) Price from Other Extracts Supplier or ManufacturerShanghai Herbary Biotechnology Co., Ltd. (piekarnia-bochen.pl)
- Commercially produced Nigella seed oil is generally obtained by cold pressing of raw or slightly roasted seeds. (piekarnia-bochen.pl)
- A. Perfect Press ® Black Cumin Oil is Perfectly Pressed ® from nothing but pure, raw, nonGMO, certified organic Nigella Sativa (black cumin) seeds. (piekarnia-bochen.pl)
- Proximate analysis of Nigella sativa L. seeds showed a composition of 21% protein, % fat, % moisture, % ash and the rest being total carbohydrate. (piekarnia-bochen.pl)
- Obtained by the first cold pressing of the seeds of the fruits, the Organic vegetable oil of Nigella is 100% pure and natural. (puressentiel.com)
- Nigella seeds, or kalonji, are an interesting spice that is used in many Indian dishes. (yogisgift.com)
- Minimum quantity for "Amir's Kalonji Oil (Nigella sativa seeds oil )- 60ml" is 1 . (my-cart.ca)
- Amir's Kalonji Oil (Nigella sativa seeds oil ) allows you to reap the complete range of health benefits associated with black seed oil. (my-cart.ca)
- Cumin, Black (Nigella sativa) - 50 Seeds is backordered and will ship as soon as it is back in stock. (southernseedexchange.com)
- Some gardeners sow the Nigella Sativa seeds in several successive weeks in order to keep a longer season. (southernseedexchange.com)
- Indigenous to the Mediterranean and now growing around the world, nigella seeds can also be used in tea or added to coffee as a unique flavoring. (grassrootsherbsupply.com)
- Virgin Black Cumin Oil, also known as black seed oil, black caraway, black cumin, kalonji, and black Nigella seeds is extracted from the Nigella sativa plant seeds in cold-pressed form. (aliveherbals.com)
- The seeds of N. sativa have been widely used in the treatment of different diseases and ailments. (jerusalem-spirit.com)
- Most of these properties have been attributed mainly to the quinone constituents of N. sativa , of which thymoquinone is the main active ingredient of the volatile oil isolated from the black seeds. (biomedcentral.com)
- One of these is a decoction comprised of Nigella sativa seeds. (who.int)
Kalonji1
- Pure and all Natural Black Seed Oil Black Seed (Nigella sativa) is also known as black cumin, nigella, kalonji, blackcaraway, blackcumin, fennelflower, nutmegflower and RomancorianderGuaranteed to be Hexane free Cold pressed in our own machine in pure black seed absolutely nothing else added. (piekarnia-bochen.pl)
Ranunculaceae6
- Nigella sativa L. (family Ranunculaceae ), also known as black cumin, has been used in cuisine around the world for many years. (mdpi.com)
- Nigella sativa (N. sativa) (Family Ranunculaceae) is a widely used medicinal plant throughout the world. (jerusalem-spirit.com)
- Nigella Sativa comes from the family Ranunculaceae, and this herb is used to treat health issues like digestive problems, diarrhea, blood sugar, and skin disorders. (tutorialspoint.com)
- Black cumin (Nigella sativa L., Ranunculaceae) is an annual herb commonly used in the Middle East, India and nowadays gaining worldwide acceptance. (haifa.ac.il)
- Nigella sativa L. , commonly known as black seed, belongs to the botanical family Ranunculaceae. (biomedcentral.com)
- Black cumin (Nigella sative L.), family Ranunculaceae, is a widely distributed annual herbaceous plant. (edu.sd)
Oxidative Stress3
- The objective of the present study was to perform a systematic review and meta-analysis on randomized controlled trials (RCTs) assessing the effects of Nigella sativa L. supplementation on the circulating inflammatory and oxidative stress markers, including C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), total antioxidant capacity (TAC) and malondialdehyde (MDA). (nih.gov)
- Nigella sativa improves glycemic control and ameliorates oxidative stress in patients with type 2 diabetes mellitus: placebo controlled randomized clinical trial. (dexcara.com)
- Concerning oxidative stress status, GEL-CH-Nigella significantly improved superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities. (europeanreview.org)
Extracts1
- Nigella sativa seed extracts have shown potential antiviral and immunomodulatory activities experimentally. (globinmed.com)
Thymoquinone2
- Antiviral - A total of six studies consisting of two human studies and four animal studies reported on Nigella sativa (Ns) and thymoquinone antiviral effects on different virus species. (globinmed.com)
- Introduction - The surge of interest in naturally occurring phytochemicals with anticancer potential has led to the discovery of many molecules, one of them being thymoquinone (TQ) the bioactive constituent of the volatile oil of black seed, Nigella sativa L. (NS). (piekarnia-bochen.pl)
Herb5
- Black Cumin The Magical Egyptian Herb Nigella sativa. (richeria-grandis.com)
- Is Black Seed Oil (Nigella sativa) a miracle herb? (piekarnia-bochen.pl)
- Nigella sativa, otherwise known as black seed oil or black cumin oil, is a natural remedy that has been popular for centuries and known in the Middle East as the most effective medical herb. (piekarnia-bochen.pl)
- A slightly more obscure herb, but powerful and respected around the globe, Nigella sativa is often called "black seed", but has a number of unique properties. (organicfacts.net)
- Black cumin, or Nigella sativa , is another herb that traditional Algerian medicine uses to treat thyroid conditions. (medicalnewstoday.com)
Herbaceous plant1
- Nigella Sativa is a small, perennial herbaceous plant with a height of approximately 20 to 30 cm. (gardenerstar.com)
Linn1
- The seed of Nigella sativa (Linn. (piekarnia-bochen.pl)
Supplementation1
- Nigella sativa supplementation is associated with improved inflammation and oxidative status. (nih.gov)
Cold-pressed2
- Ingredient: pure and cold pressed black seed oil (Nigella sativa). (piekarnia-bochen.pl)
- 2oz Pure Natural Black Seed Oil Cold Pressed Cumin Nigella Sativa NonGMO. (piekarnia-bochen.pl)
Supplements1
- Purpose To assess the effect of Nigella sativa (NS) oil supplements on CVD risk factors in a crossover design for the first time. (inbody.com)
Vegetable3
- Nigella sativa seed oil is a vegetable oil used as an emollient. (loreal.com)
- Enjoy 50% OFF on Organic Vegetable Oil Nigella Sativa. (puressentiel.com)
- Yellow-green to orange-amber in colour, the Organic vegetable oil of Nigella has a spicy, pungent, very aromatic smell. (puressentiel.com)
Antibacterial4
- The primary goal of our study was to assess Nigella sativa's (N. sativa) antibacterial effectiveness against Porphyromonas gingivalis (P. gingivalis) utilizing seed extract. (europeanreview.org)
- Although N. sativa samples had somewhat less antibacterial activity than tetracycline samples, it was discovered that N. sativa had noticeable antibacterial activity against P. gingivalis. (europeanreview.org)
- This study's findings suggest that N. sativa can be utilized against periodontitis as an adjunct to scaling since it has high antibacterial action against P. gingivalis. (europeanreview.org)
- Antibacterial and anti-corona virus (229E) activity of Nigella sativa oil combined with photodynamic therapy based on methylene blue in wound infection: in vitro and in vivo study. (bvsalud.org)
Spice2
- In the United States, the Food and Drug Administration classifies Nigella sativa as Generally Recognized as Safe (GRAS) for use as a spice, natural seasoning, or flavouring. (wikipedia.org)
- Garlic (Allium sativum L.) Has been used worldwide for centuries as a spice, food and folklore medicine to cure and prevent various illnesses. (edu.sd)
Prevention and treatment2
- The first major study of Nigella sativa in cancer prevention and treatment was performed by scientists at Cancer Immuno-Biology Laboratory of Hilton Head Island, South Carolina. (richeria-grandis.com)
- In present study we examined the influence of Ginger, Nigella sativa, Punica granatum and Metformin on the prevention and treatment of bone damage and infections due to Diabetes Mellitus in STZ-induced diabetes in male Wistar albino rats. (microbiologyjournal.org)
Medicinal plant1
- Black Cumin ( Nigella Sativa ) is a powerful medicinal plant, and the oil is a concentrated essence. (livingtreecommunityfoods.com)
Significantly1
- N. sativa petroleum ether extract significantly lowered fasting plasma levels of insulin and triglycerides and normalized HDL-cholesterol. (biomedcentral.com)
Metabolism1
- This review elaborates the importance of phytogenic substances i.e. myrtle plant and Nigella sativa by exerting positive effects on metabolism and particularly enhancing the immunity of rats which is used as a human model. (florajournal.com)
Therapeutic1
- According to the 2013 small-scale study comparing the therapeutic benefits of N. Sativa with prescription drugs, black seed oil can reduce the severity of hand eczema. (aliveherbals.com)
Mediterranean1
- Black seed (Nigella sativa) is a flowering plant native to Asia and the Mediterranean. (medlineplus.gov)
Effect2
- Evaluate The Effect of Nigella Sativa. (grin.com)
- Many studies have also examined the anti-diabetic effect of N. sativa in diabetic animal models. (biomedcentral.com)
Effects4
- The present study investigated the effects of Nigella sativa hydroalcholic extract on glucose concentrations in streptozotocin (STZ) diabetic rats. (biomedcentral.com)
- The oil of N. sativa exhibits analgesic and anti-inflammatory effects in rats. (biomedcentral.com)
- Hepatoprotective effects of Nigella sati. (yyu.edu.tr)
- AIM: To investigate the effects of Nigella sativa L (NS) and Urtica dioica L (UD) on lipid peroxidation, antioxidant enzyme systems and liver enzymes in CCl4-treated rats. (yyu.edu.tr)
Glutathione1
- whether a decoction of Nigella sativa, Hemidesmus indicus and Smilax glabra ubhibits glutathione S-transferase (GST-P) expression in rat liver. (who.int)
Study1
- Our study targeted solving this problem with Nigella sativa (NS) oil and photodynamic therapy based on methylene blue (MB-PDT). (bvsalud.org)
Antioxidants1
- This metabolic disorder is classically notorious to cause retinopathy, neuropathy, micro and macro vascular complications including brain damage, cardiac disorders and nephropathy and renders patients to develop various kinds of infections Ginger, Nigella sativa and Punica granatum are strong antioxidants and possess antimicrobial activity. (microbiologyjournal.org)
Cholesterol1
- One meta-analysis of clinical trials found weak evidence that N. sativa has a short-term benefit on lowering systolic and diastolic blood pressure, with limited evidence that black seed oil or powder can reduce triglycerides and LDL and total cholesterol, while raising HDL cholesterol. (wikipedia.org)
Family1
- Whether you're looking to express your love for a partner, a family member, or a friend, these Bicolor Nigella Sativas are the ideal choice. (gardenerstar.com)
Possess1
- N. sativa extract has been shown to possess immunopotentiating, anti-oxidant, anti-tumoral, and anti-diabetic properties. (biomedcentral.com)
Treatment2
- The Muslim physician Avicenna described N. sativa as a treatment for dyspnea in his The Canon of Medicine. (wikipedia.org)
- Consequently, N. sativa may prove clinically useful in the treatment of diabetics and in the protection of β-cells against streptozotocin. (biomedcentral.com)
Potential2
- Nigella Sativa is thought to have potential health benefits such as antioxidant, anti-inflammatory, anti-microbial and anti-cancer. (gardenerstar.com)
- Natural wound dressings composed of gelatin (GEL) and chitosan (CH) impregnated with bioactive compounds (Nigella sativa oil) were prepared and characterized to evaluate their potential application. (europeanreview.org)
Medicine1
- N. sativa was used in the Middle East as a traditional medicine. (wikipedia.org)
Analysis1
- A histological analysis revealed that GEL-CH-Nigella accelerated wound closure and improved collagenisation and enhanced epidermal tissue thickness. (europeanreview.org)