Odontogenic Cysts
Ameloblastoma
Jaw Neoplasms
Odontogenic Cyst, Calcifying
Odontoma
Odontogenic Tumor, Squamous
Dentigerous Cyst
Radicular Cyst
Gingival Neoplasms
Jaw Diseases
Maxillary Diseases
Radiography, Panoramic
Tooth, Impacted
Adenomatoid Tumor
Myxoma
Odontogenesis
Focal Infection, Dental
Basal Cell Nevus Syndrome
Mandibular Diseases
Fibroma, Ossifying
Periodontal Cyst
Periodontal Abscess
Mandibular Prosthesis Implantation
Maxillary Sinus Neoplasms
Photomicrography
Tumor Markers, Biological
Mandible
Root Resorption
Neoplasms, Multiple Primary
Keratins
Retrospective Studies
Biological Specimen Banks
Immunohistochemistry
Primary intraosseous carcinoma and odontogenic cyst. Three new cases and review of the literature. (1/3)
INTRODUCTION: The Odontogenic Primary Intraosseous Carcinoma (PIOC) are a rare group of malignant tumours with strict clinic and anatomy pathological diagnosis criteria. The different classification suggested for these tumours and the small amount of cases described in literature makes it hard to know exactly how many of the cases published until now are real. MATERIAL AND METHODS: We present three new cases of PIOC originated from a previous cystic lesion that where treated in our Hospital. Two of them in the posterior jaw region where is more frequent, and the third in the upper jaw. We explain the procedure we used in each case and the aesthetic-functional reconstruction used witches are two fibula osteomyocutaneous free flaps and a bone graft of iliac crest and further placing of implants. The classification, the clinical and radiological diagnosis, the treatment and its survival are discussed. RESULTS: In all three cases we were able to see in the anatomy pathological study an epithelial, exclusively without surrounding oral mucosa affectation or tissues near the lesion as well as the lack of tumorous pathology in other parts of the body. One of the patients died because of premature massive cervical recidiva while the other two patients are currently free form illness, for ten years one of them and fifteen months the other. CONCLUSIONS: The anatomy pathological study of all of the lesions of cystic characteristics at jaw level is very important because of the risk of coexisting with carcinomatous cells. The treatment of these tumours consists in practising aggressive surgery and, in some cases, radio and/or chemotherapy post intervention. (+info)Squamous odontogenic tumor of the mandible: a case report demonstrating immunoexpression of Notch1, 3, 4, Jagged1 and Delta1. (2/3)
BACKGROUND: Squamous odontogenic tumor (SOT) is a rare benign odontogenic epithelial neoplasm. A slow-growing painless expansive swelling is the common presenting symptom. Histopathologically, SOT can be easily misdiagnosed as an acanthomatous ameloblastoma. Although Notch receptors and ligands have been shown to play a role in cell fate decisions in ameloblastomas, the role of these cell signaling molecules in SOT is unknown. CASE REPORT: This paper describes a case of SOT affecting the anterior mandible of a 10-year-old Indian female. The patient was treated by local surgical excision and there has been no follow-up clinical record of recurrence 5 years after primary treatment. Histo?pathological examination revealed a solid, locally-infiltrative neoplasm composed of bland-looking squamatoid islands scattered in a mature fibrous connective tissue stroma and the diagnosis was SOT. Immunohistochemical evaluation showed positive reactivity of varying intensity in the neoplastic epithelial cells for Notch1, Notch3, Notch4, and their ligands Jagged1 and Delta1. Expression patterns showed considerable overlap. No immunoreactivity was detected for Notch2 and Jagged2. CONCLUSIONS: Present findings suggest that Notch receptors and their ligands play differential roles in the cytodifferentiation of SOT. (+info)Squamous odontogenic tumor. (3/3)
(+info)Odontogenic tumors are a group of neoplasms that originate from the dental tissues or their remnants, including the odontogenic epithelium, ectomesenchyme, and/or their derivatives. These tumors can be benign or malignant and may affect the jaw bones and surrounding structures. They can cause various symptoms, such as swelling, pain, loosening of teeth, and altered bite. The classification of odontogenic tumors includes a wide range of entities with different biological behaviors, clinical features, and treatment approaches. Accurate diagnosis is essential for proper management and prognosis.
Odontogenic cysts are a type of cyst that originates from the dental tissues or odontogenic apparatus. They are typically found in the jawbones, and can be classified as developmental or inflammatory in origin. Developmental odontogenic cysts arise from remnants of the tooth-forming structures, while inflammatory odontogenic cysts result from an infection or injury to a tooth.
The most common types of odontogenic cysts include:
1. Periapical cyst - an inflammatory cyst that forms at the tip of the root of a dead or non-vital tooth.
2. Dentigerous cyst - a developmental cyst that surrounds the crown of an unerupted or impacted tooth.
3. Follicular cyst - a type of dentigerous cyst that forms around the crown of an unerupted wisdom tooth.
4. Odontogenic keratocyst - a developmental cyst that arises from the dental lamina and has a high recurrence rate.
5. Lateral periodontal cyst - a rare, developmental cyst that forms in the periodontal ligament of a vital tooth.
Odontogenic cysts can cause various symptoms such as swelling, pain, or numbness in the affected area. They may also displace or resorb adjacent teeth. Diagnosis is typically made through radiographic imaging and histopathological examination of tissue samples obtained through biopsy. Treatment options include surgical excision, marsupialization (a procedure that creates an opening between the cyst and oral cavity), or enucleation (removal of the cyst lining).
Ameloblastoma is a slow-growing, non-cancerous tumor that develops in the jawbone, typically in the lower jaw. It originates from the cells that form the enamel (the hard, outer surface of the teeth). This tumor can cause swelling, pain, and displacement or loosening of teeth. In some cases, it may also lead to fractures of the jawbone.
There are different types of ameloblastomas, including solid or multicystic, unicystic, and peripheral ameloblastoma. Treatment usually involves surgical removal of the tumor, with careful monitoring to ensure that it does not recur. In rare cases, more aggressive treatment may be necessary if the tumor is large or has invaded surrounding tissues.
It's important to note that while ameloblastomas are generally benign, they can still cause significant morbidity and should be treated promptly by an oral and maxillofacial surgeon or other qualified healthcare professional.
Jaw neoplasms refer to abnormal growths or tumors in the jawbone (mandible) or maxilla (upper jaw). These growths can be benign (non-cancerous) or malignant (cancerous). Benign neoplasms are not considered life-threatening, but they can still cause problems by invading nearby tissues and causing damage. Malignant neoplasms, on the other hand, can spread to other parts of the body and can be life-threatening if not treated promptly and effectively.
Jaw neoplasms can present with various symptoms such as swelling, pain, loose teeth, numbness or tingling in the lips or tongue, difficulty chewing or swallowing, and jaw stiffness or limited movement. The diagnosis of jaw neoplasms typically involves a thorough clinical examination, imaging studies such as X-rays, CT scans, or MRI, and sometimes a biopsy to determine the type and extent of the tumor.
Treatment options for jaw neoplasms depend on several factors, including the type, size, location, and stage of the tumor, as well as the patient's overall health and medical history. Treatment may involve surgery, radiation therapy, chemotherapy, or a combination of these modalities. Regular follow-up care is essential to monitor for recurrence or metastasis (spread) of the neoplasm.
Mandibular neoplasms refer to abnormal growths or tumors that develop in the mandible, which is the lower jawbone. These growths can be benign (non-cancerous) or malignant (cancerous). Benign neoplasms are typically slow-growing and rarely spread to other parts of the body, while malignant neoplasms can invade surrounding tissues and may metastasize (spread) to distant sites.
Mandibular neoplasms can have various causes, including genetic mutations, exposure to certain chemicals or radiation, and infection with certain viruses. The symptoms of mandibular neoplasms may include swelling or pain in the jaw, difficulty chewing or speaking, numbness in the lower lip or chin, loose teeth, and/or a lump or mass in the mouth or neck.
The diagnosis of mandibular neoplasms typically involves a thorough clinical examination, imaging studies such as X-rays, CT scans, or MRI scans, and sometimes a biopsy to confirm the type and extent of the tumor. Treatment options depend on the type, stage, and location of the neoplasm, and may include surgery, radiation therapy, chemotherapy, or a combination of these approaches. Regular follow-up care is essential to monitor for recurrence or metastasis.
An Odontogenic Cyst, Calcifying is a specific type of cyst that originates from the dental tissues. It's also known as a calcifying odontogenic cyst or Gorlin cyst. This cyst is characterized by the presence of calcified structures within its lining.
The calcifications can appear as flecks or more complex structures, such as teeth-like formations. The lining of this cyst often contains ghost cells, which are the remains of epithelial cells that have undergone calcification.
These cysts are typically slow-growing and asymptomatic, although they can sometimes cause swelling or pain if they become large enough to compress adjacent tissues. They are most commonly found in the jaw bones, particularly the mandible.
While the exact cause of calcifying odontogenic cysts is not fully understood, they are thought to arise from developmental abnormalities in the tissues that form teeth. Treatment typically involves surgical removal of the cyst.
Maxillary neoplasms refer to abnormal growths or tumors in the maxilla, which is the upper jaw bone. These growths can be benign (non-cancerous) or malignant (cancerous). Benign neoplasms are slow-growing and do not spread to other parts of the body, while malignant neoplasms can invade surrounding tissues and spread to distant sites.
Maxillary neoplasms can cause various symptoms such as swelling, pain, numbness, loose teeth, or difficulty in chewing or swallowing. They may also cause nasal congestion, nosebleeds, or visual changes if they affect the eye or orbit. The diagnosis of maxillary neoplasms usually involves a combination of clinical examination, imaging studies such as CT or MRI scans, and biopsy to determine the type and extent of the tumor.
Treatment options for maxillary neoplasms depend on several factors, including the type, size, location, and stage of the tumor, as well as the patient's overall health and preferences. Treatment may include surgery, radiation therapy, chemotherapy, or a combination of these modalities. Regular follow-up care is essential to monitor for recurrence or metastasis and ensure optimal outcomes.
Odontoma is a type of odontogenic tumor, which means it arises from the tissues that form teeth. It is considered a benign or non-cancerous tumor and is typically slow-growing. Odontomas are usually asymptomatic and are often discovered on routine dental X-rays or during procedures such as wisdom tooth removal.
Odontomas can be classified into two types: complex and compound. Complex odontomas are composed of a haphazard mixture of dental tissue, including enamel, dentin, and cementum, while compound odontomas contain small tooth-like structures called denticles.
These tumors typically occur in the posterior region of the jaw, and while they are usually asymptomatic, some patients may experience symptoms such as swelling, pain, or displacement of teeth. Treatment for odontomas typically involves surgical removal of the tumor.
An odontogenic tumor, squamous type, refers to a specific category of oral tumors that originate from the dental tissues. These tumors are characterized by the abnormal growth of squamous epithelial cells, which are normally found in the outermost layer of the skin and the mucous membranes, including those inside the mouth.
Odontogenic tumors can arise from various components of the dental tissues, such as the odontoblasts, dentin, enamel, cementum, or the epithelial rests of Malassez. The squamous type of odontogenic tumor is typically classified under either one of the following entities:
1. Squamous Odontogenic Tumor (SOT): This is a rare, benign (non-cancerous) neoplasm that primarily affects the tooth-bearing areas of the jaws. SOT is composed of well-differentiated squamous epithelial cells arranged in nests, strands, or sheets, often surrounded by a fibrous stroma. This tumor typically occurs in adults during their third to fifth decades of life and has a slight female predilection.
2. Ameloblastoma with Squamous Metaplasia: Ameloblastoma is a more common odontogenic tumor that usually affects the mandible (lower jaw). In some cases, ameloblastomas may undergo squamous metaplasia, where the original epithelial cells transform into squamous epithelial cells. This variant of ameloblastoma is still considered a benign neoplasm; however, it has a higher recurrence rate compared to conventional ameloblastomas.
It is essential to differentiate these entities from other oral lesions and malignancies through histopathological examination, as the treatment and prognosis may vary depending on the specific diagnosis.
A dentigerous cyst is a type of odontogenic cyst that forms around the crown of an unerupted tooth. It is typically slow-growing and often asymptomatic, but it can cause displacement or resorption of adjacent teeth if it becomes large enough. Dentigerous cysts are more common in permanent teeth than primary teeth, and they are more likely to occur in the mandible (lower jaw) than the maxilla (upper jaw). They are usually diagnosed through radiographic examination and can be treated by surgical removal of the cyst along with the affected tooth. If left untreated, dentigerous cysts can continue to grow and may eventually develop into a tumor or cancer.
A radicular cyst is a type of dental cyst that forms around the root of a tooth, usually as a result of chronic infection or inflammation. It is also known as a periapical cyst. The cyst develops from the accumulation of fluid and cells in the periodontal ligament, which is the tissue that connects the tooth to the jawbone.
Radicular cysts are often caused by untreated dental caries or trauma to the tooth that allows bacteria to enter the pulp chamber of the tooth and cause an infection. Over time, the infection can spread to the surrounding tissues, leading to the formation of a cyst. Symptoms of a radicular cyst may include pain, swelling, and tenderness in the affected area. Treatment typically involves removing the affected tooth and the cyst through a surgical procedure.
Gingival neoplasms refer to abnormal growths or tumors that occur in the gingiva, which are the part of the gums that surround the teeth. These growths can be benign (non-cancerous) or malignant (cancerous). Benign neoplasms include conditions such as fibromas, papillomas, and hemangiomas, while malignant neoplasms are typically squamous cell carcinomas.
Gingival neoplasms can present with a variety of symptoms, including swelling, bleeding, pain, and loose teeth. They may also cause difficulty with chewing, speaking, or swallowing. The exact cause of these neoplasms is not always known, but risk factors include tobacco use, alcohol consumption, poor oral hygiene, and certain viral infections.
Diagnosis of gingival neoplasms typically involves a thorough clinical examination, including a dental exam and biopsy. Treatment options depend on the type and stage of the neoplasm, but may include surgery, radiation therapy, chemotherapy, or a combination of these approaches. Regular dental check-ups and good oral hygiene practices can help to detect gingival neoplasms at an early stage and improve treatment outcomes.
Jaw diseases refer to a variety of conditions that affect the temporomandibular joint (TMJ) and the surrounding muscles, as well as dental disorders that can impact the jaw. Some common examples include:
1. Temporomandibular Joint Disorders (TMD): These are problems with the TMJ and the muscles that control jaw movement. Symptoms may include pain, clicking or popping sounds, and limited movement of the jaw.
2. Osteonecrosis of the Jaw: This is a condition where bone in the jaw dies due to lack of blood supply. It can be caused by radiation therapy, chemotherapy, or certain medications.
3. Dental Cavities: These are holes in the teeth caused by bacteria. If left untreated, they can cause pain, infection, and damage to the jawbone.
4. Periodontal Disease: This is an infection of the gums and bones that support the teeth. Advanced periodontal disease can lead to loss of teeth and damage to the jawbone.
5. Jaw Fractures: These are breaks in the jawbone, often caused by trauma.
6. Oral Cancer: This is a type of cancer that starts in the mouth or throat. If not treated early, it can spread to the jaw and other parts of the body.
7. Cysts and Tumors: These are abnormal growths in the jawbone or surrounding tissues. While some are benign (non-cancerous), others can be malignant (cancerous).
8. Osteomyelitis: This is an infection of the bone, often occurring in the lower jaw. It can cause pain, swelling, and fever.
9. Oral Thrush: This is a fungal infection that causes white patches on the inside of the mouth. If left untreated, it can spread to the jaw and other parts of the body.
10. Sinusitis: Inflammation of the sinuses can sometimes cause pain in the upper jaw.
Maxillary diseases refer to conditions that affect the maxilla, which is the upper bone of the jaw. This bone plays an essential role in functions such as biting, chewing, and speaking, and also forms the upper part of the oral cavity, houses the upper teeth, and supports the nose and the eyes.
Maxillary diseases can be caused by various factors, including infections, trauma, tumors, congenital abnormalities, or systemic conditions. Some common maxillary diseases include:
1. Maxillary sinusitis: Inflammation of the maxillary sinuses, which are air-filled cavities located within the maxilla, can cause symptoms such as nasal congestion, facial pain, and headaches.
2. Periodontal disease: Infection and inflammation of the tissues surrounding the teeth, including the gums and the alveolar bone (which is part of the maxilla), can lead to tooth loss and other complications.
3. Maxillary fractures: Trauma to the face can result in fractures of the maxilla, which can cause pain, swelling, and difficulty breathing or speaking.
4. Maxillary cysts and tumors: Abnormal growths in the maxilla can be benign or malignant and may require surgical intervention.
5. Oral cancer: Cancerous lesions in the oral cavity, including the maxilla, can cause pain, swelling, and difficulty swallowing or speaking.
Treatment for maxillary diseases depends on the specific condition and its severity. Treatment options may include antibiotics, surgery, radiation therapy, or chemotherapy. Regular dental check-ups and good oral hygiene practices can help prevent many maxillary diseases.
Panoramic radiography is a specialized type of dental X-ray imaging that captures a panoramic view of the entire mouth, including the teeth, upper and lower jaws, and surrounding structures. It uses a special machine that rotates around the head, capturing images as it moves. This technique provides a two-dimensional image that is helpful in diagnosing and planning treatment for various dental conditions such as impacted teeth, bone abnormalities, and jaw disorders.
The panoramic radiograph can also be used to assess the development and positioning of wisdom teeth, detect cysts or tumors in the jaws, and evaluate the effects of trauma or injury to the mouth. It is a valuable tool for dental professionals as it allows them to see a comprehensive view of the oral structures, which may not be visible with traditional X-ray techniques.
It's important to note that while panoramic radiography provides valuable information, it should be used in conjunction with other diagnostic tools and clinical examinations to ensure accurate diagnosis and treatment planning.
An impacted tooth is a condition where a tooth fails to erupt into the oral cavity within its expected time frame, resulting in its partial or complete entrapment within the jawbone or soft tissues. This commonly occurs with wisdom teeth (third molars) but can affect any tooth. Impacted teeth may cause problems such as infection, decay of adjacent teeth, gum disease, or cyst formation, and they may require surgical removal.
A Follicular Cyst is a type of cyst that forms within a follicle, which is the sac-like structure in the skin that contains and protects a hair root. In particular, it refers to a specific condition in the ovary where a follicle fails to rupture or release an egg after maturation, instead continuing to grow and fill with fluid, forming a cyst. These cysts are usually asymptomatic but can become large and cause symptoms such as pelvic pain or discomfort, irregular menstrual cycles, or abnormal vaginal bleeding. In most cases, follicular cysts resolve on their own within 2-3 menstrual cycles, but in rare cases, they may require medical intervention if they become complicated or do not resolve.
A fibroma is a benign (non-cancerous) tumor that consists primarily of fibrous or connective tissue. It can occur in various parts of the body, including the skin, mouth, and internal organs. The term "fibroma" is often used to describe any benign fibrous growth, but there are specific types of fibromas such as dermatofibroma (found in the skin), oral fibroma (found in the mouth), and benign fibrous histiocytoma (found in soft tissues).
It's important to note that while fibromas are generally harmless, they can cause discomfort or problems depending on their size and location. If a fibroma is causing issues or there's concern about its growth or malignancy, it should be evaluated by a healthcare professional for potential removal or further assessment.
An adenomatoid tumor is a benign (non-cancerous) neoplasm that typically arises in the serosal surfaces of the reproductive organs, such as the epididymis in men and the fallopian tube or uterus in women. These tumors are composed of epithelioid cells arranged in tubules, glands, or cysts, and they can sometimes be mistaken for malignant tumors due to their gross appearance. However, adenomatoid tumors are generally slow-growing and do not spread to other parts of the body. They are usually treated with surgical excision and have an excellent prognosis.
A myxoma is a type of benign (non-cancerous) tumor that develops in the heart, specifically in the heart's chambers or valves. It is the most common primary cardiac tumor in adults and typically affects the left atrium. Myxomas are composed of gelatinous, mucoid material and may have a stalk-like attachment to the endocardium (the inner lining of the heart).
Myxomas can vary in size and may cause symptoms such as shortness of breath, fatigue, chest pain, coughing, and fever. These symptoms are due to obstruction of blood flow within the heart or embolization (detachment and travel) of tumor fragments to other parts of the body. Surgical removal is usually required to treat myxomas, as they can lead to serious complications if left untreated.
Odontogenesis is the process of tooth development that involves the formation and calcification of teeth. It is a complex process that requires the interaction of several types of cells, including epithelial cells, mesenchymal cells, and odontoblasts. The process begins during embryonic development with the formation of dental lamina, which gives rise to the tooth bud. As the tooth bud grows and differentiates, it forms the various structures of the tooth, including the enamel, dentin, cementum, and pulp. Odontogenesis is completed when the tooth erupts into the oral cavity. Abnormalities in odontogenesis can result in developmental dental anomalies such as tooth agenesis, microdontia, or odontomas.
A focal infection is a focus or source of infection that can spread and cause harm to other parts of the body. A "focal infection, dental" refers to an infection that originates in the teeth or surrounding tissues of the mouth and then spreads to other parts of the body. This can occur when bacteria or other pathogens from a dental infection enter the bloodstream and travel to distant sites, where they can cause inflammation, tissue damage, and illness.
Dental focal infections can be caused by various conditions, such as tooth decay, periodontal disease, abscesses, or other oral infections. The bacteria involved in dental infections are often part of the normal oral flora but can become pathogenic under certain circumstances, such as when they gain access to deeper tissues or the bloodstream due to trauma, surgery, or poor oral hygiene.
If left untreated, dental focal infections can lead to serious health complications, including heart disease, brain abscesses, and other systemic infections. It is essential to maintain good oral hygiene and seek professional dental care to prevent and treat dental infections, reducing the risk of developing focal infections and related health issues.
Basal Cell Nevus Syndrome (BCNS), also known as Gorlin-Goltz Syndrome, is a rare genetic disorder that is characterized by the development of multiple basal cell carcinomas (BCCs), which are skin cancer tumors that arise from the basal cells in the outermost layer of the skin.
The syndrome is caused by mutations in the PTCH1 gene, which regulates the hedgehog signaling pathway involved in embryonic development and tissue growth regulation. The condition is inherited in an autosomal dominant manner, meaning that a child has a 50% chance of inheriting the mutated gene from an affected parent.
Individuals with BCNS typically develop hundreds to thousands of BCCs over their lifetime, often beginning in childhood or adolescence. They may also have other benign and malignant tumors, such as medulloblastomas (brain tumors), fibromas, and rhabdomyosarcomas.
Additional features of BCNS can include:
1. Facial abnormalities, such as a broad nasal bridge, widely spaced eyes, and pits or depressions on the palms and soles.
2. Skeletal abnormalities, such as spine deformities, rib anomalies, and jaw cysts.
3. Developmental delays and intellectual disabilities in some cases.
4. Increased risk of other cancers, including breast, ovarian, and lung cancer.
Early detection and management of BCCs and other tumors are crucial for individuals with BCNS to prevent complications and improve their quality of life. Regular dermatological examinations, sun protection measures, and surgical removal of tumors are common treatment approaches.
Mandibular diseases refer to conditions that affect the mandible, or lower jawbone. These diseases can be classified as congenital (present at birth) or acquired (developing after birth). They can also be categorized based on the tissues involved, such as bone, muscle, or cartilage. Some examples of mandibular diseases include:
1. Mandibular fractures: These are breaks in the lower jawbone that can result from trauma or injury.
2. Osteomyelitis: This is an infection of the bone and surrounding tissues, which can affect the mandible.
3. Temporomandibular joint (TMJ) disorders: These are conditions that affect the joint that connects the jawbone to the skull, causing pain and limited movement.
4. Mandibular tumors: These are abnormal growths that can be benign or malignant, and can develop in any of the tissues of the mandible.
5. Osteonecrosis: This is a condition where the bone tissue dies due to lack of blood supply, which can affect the mandible.
6. Cleft lip and palate: This is a congenital deformity that affects the development of the face and mouth, including the lower jawbone.
7. Mandibular hypoplasia: This is a condition where the lower jawbone does not develop properly, leading to a small or recessed chin.
8. Developmental disorders: These are conditions that affect the growth and development of the mandible, such as condylar hyperplasia or hemifacial microsomia.
A fibroma, ossifying is a benign (non-cancerous) tumor that typically develops in the periodontal ligament, which is the tissue that connects the tooth to the jawbone. This type of fibroma is characterized by the formation of bone-like tissue within the tumor. It usually appears as a firm, slow-growing nodule or mass that can cause pain or discomfort, particularly when biting down on the affected tooth.
The exact cause of ossifying fibromas is not well understood, but they are thought to arise from an overgrowth of cells in the periodontal ligament. They are more common in women than men and typically occur in people between the ages of 20 and 40. Treatment usually involves surgical removal of the tumor, along with any affected tissue or teeth. In some cases, recurrence may occur, so regular follow-up appointments with a dental professional are recommended.
A periodontal cyst, also known as a radicular cyst or dental cyst, is a type of odontogenic cyst that forms from the tissue of the periodontium, which surrounds and supports the teeth. It typically develops at the apex (tip) of a dead or non-vital tooth root and is filled with fluid. The cyst can grow slowly and painlessly, often going unnoticed until it becomes quite large or causes symptoms such as swelling, tenderness, or tooth mobility.
Periodontal cysts are usually asymptomatic and are often discovered during routine dental x-rays. If left untreated, they can eventually lead to the destruction of surrounding bone and tissue, potentially causing teeth to become loose or even fall out. Treatment typically involves surgical removal of the cyst along with the affected tooth, followed by careful monitoring to ensure that the cyst does not recur.
Cyst fluid refers to the fluid accumulated within a cyst, which is a closed sac-like or capsular structure, typically filled with liquid or semi-solid material. Cysts can develop in various parts of the body for different reasons, and the composition of cyst fluid may vary depending on the type of cyst and its location.
In some cases, cyst fluid might contain proteins, sugars, hormones, or even cells from the surrounding tissue. Infected cysts may have pus-like fluid, while cancerous or precancerous cysts might contain abnormal cells or tumor markers. The analysis of cyst fluid can help medical professionals diagnose and manage various medical conditions, including infections, inflammatory diseases, genetic disorders, and cancers.
It is important to note that the term 'cyst fluid' generally refers to the liquid content within a cyst, but the specific composition and appearance of this fluid may vary significantly depending on the underlying cause and type of cyst.
A periodontal abscess is a localized collection of pus in the tissues surrounding and supporting the teeth, caused by an infection. It's typically characterized by symptoms such as pain, swelling, redness, and sometimes drainage of pus from the affected area. The infection usually arises from dental plaque that accumulates on the teeth and gums, leading to periodontal disease. If left untreated, a periodontal abscess can result in tissue destruction, bone loss, and even tooth loss. Treatment typically involves draining the abscess, removing any infected tissue, and providing oral hygiene instruction to prevent future infections. In some cases, antibiotics may also be prescribed to help clear up the infection.
Mandibular prosthesis implantation is a dental surgical procedure that involves the placement of dental implants into the mandible (lower jawbone) to support and retain a prosthetic restoration, such as a denture or fixed bridge. This procedure is typically performed to restore oral function, aesthetics, and quality of life for patients who have lost all or most of their natural lower teeth due to injury, decay, or other reasons.
The implantation process typically involves several steps. First, the dental surgeon will carefully evaluate the patient's jawbone density and overall oral health to determine if they are a good candidate for the procedure. If so, the surgeon will then place one or more titanium implants into the mandible, using specialized surgical techniques to ensure proper placement and alignment.
After the implant(s) have been placed, the patient will typically undergo a healing period of several months, during which time the jawbone will gradually fuse with the implant(s) in a process called osseointegration. Once this process is complete, the surgeon will attach an abutment to each implant, which will serve as a connector between the implant and the prosthetic restoration.
Finally, the dental prosthesis (such as a denture or bridge) will be fabricated and attached to the abutments, providing a stable and secure replacement for the missing teeth. With proper care and maintenance, mandibular prosthesis implantation can provide a long-lasting and effective solution for patients with significant tooth loss.
Maxillary sinus neoplasms refer to abnormal growths or tumors that develop in the maxillary sinuses, which are located in the upper part of your cheekbones, below your eyes. These growths can be benign (non-cancerous) or malignant (cancerous).
Benign neoplasms may include conditions such as an osteoma (a benign bone tumor), a papilloma (a benign growth of the lining of the sinus), or a fibrous dysplasia (a condition where bone is replaced by fibrous tissue).
Malignant neoplasms, on the other hand, can be primary (originating in the maxillary sinuses) or secondary (spreading to the maxillary sinuses from another site in the body). Common types of malignant tumors that arise in the maxillary sinus include squamous cell carcinoma, adenocarcinoma, and mucoepidermoid carcinoma.
Symptoms of maxillary sinus neoplasms may include nasal congestion, nosebleeds, facial pain or numbness, vision changes, and difficulty swallowing or speaking. Treatment options depend on the type, size, and location of the tumor but may include surgery, radiation therapy, chemotherapy, or a combination of these approaches.
A third molar is the most posterior of the three molars present in an adult human dental arch. They are also commonly known as wisdom teeth, due to their late eruption period which usually occurs between the ages of 17-25, a time traditionally associated with gaining maturity and wisdom.
Anatomically, third molars have four cusps, making them the largest of all the teeth. However, not everyone develops third molars; some people may have one, two, three or no third molars at all. In many cases, third molars do not have enough space to fully erupt and align properly with the rest of the teeth, leading to impaction, infection, or other dental health issues. As a result, third molars are often extracted if they cause problems or if there is a risk they will cause problems in the future.
Dental enamel is the hard, outermost layer of a tooth that protects the dentin and pulp inside. It is primarily made up of minerals, mainly hydroxyapatite, and contains very little organic material. However, during the formation of dental enamel, proteins are synthesized and secreted by ameloblast cells, which help in the development and mineralization of the enamel. These proteins play a crucial role in the proper formation and structure of the enamel.
Some of the main dental enamel proteins include:
1. Amelogenin: This is the most abundant protein found in developing enamel, accounting for about 90% of the organic matrix. Amelogenin helps regulate the growth and organization of hydroxyapatite crystals during mineralization. It also plays a role in determining the final hardness and structure of the enamel.
2. Enamelin: This protein is the second most abundant protein in developing enamel, accounting for about 5-10% of the organic matrix. Enamelin is involved in the elongation and thickening of hydroxyapatite crystals during mineralization. It also helps maintain the stability of the enamel structure.
3. Ameloblastin: This protein is produced by ameloblast cells and is essential for proper enamel formation. Ameloblastin plays a role in regulating crystal growth, promoting adhesion between crystals, and maintaining the structural integrity of the enamel.
4. Tuftelin: This protein is found in both dentin and enamel but is more abundant in enamel. Tuftelin is involved in the initiation of mineralization and helps regulate crystal growth during this process.
5. Dentin sialophosphoprotein (DSPP): Although primarily associated with dentin formation, DSPP is also found in developing enamel. It plays a role in regulating crystal growth and promoting adhesion between crystals during mineralization.
After the formation of dental enamel is complete, these proteins are largely degraded and removed, leaving behind the highly mineralized and hard tissue that characterizes mature enamel. However, traces of these proteins may still be present in the enamel and could potentially play a role in its structure and properties.
Photomicrography is not a medical term per se, but it is a technique often used in the field of medicine and pathology. It refers to the process of taking photographs through a microscope, using specialized equipment and techniques to capture detailed images of specimens or structures that are too small to be seen by the naked eye. These images can be used for various purposes, such as medical research, diagnosis, education, and publication.
In summary, photomicrography is the photography of microscopic subjects, which can have many applications in the medical field.
Tumor markers are substances that can be found in the body and their presence can indicate the presence of certain types of cancer or other conditions. Biological tumor markers refer to those substances that are produced by cancer cells or by other cells in response to cancer or certain benign (non-cancerous) conditions. These markers can be found in various bodily fluids such as blood, urine, or tissue samples.
Examples of biological tumor markers include:
1. Proteins: Some tumor markers are proteins that are produced by cancer cells or by other cells in response to the presence of cancer. For example, prostate-specific antigen (PSA) is a protein produced by normal prostate cells and in higher amounts by prostate cancer cells.
2. Genetic material: Tumor markers can also include genetic material such as DNA, RNA, or microRNA that are shed by cancer cells into bodily fluids. For example, circulating tumor DNA (ctDNA) is genetic material from cancer cells that can be found in the bloodstream.
3. Metabolites: Tumor markers can also include metabolic products produced by cancer cells or by other cells in response to cancer. For example, lactate dehydrogenase (LDH) is an enzyme that is released into the bloodstream when cancer cells break down glucose for energy.
It's important to note that tumor markers are not specific to cancer and can be elevated in non-cancerous conditions as well. Therefore, they should not be used alone to diagnose cancer but rather as a tool in conjunction with other diagnostic tests and clinical evaluations.
The mandible, also known as the lower jaw, is the largest and strongest bone in the human face. It forms the lower portion of the oral cavity and plays a crucial role in various functions such as mastication (chewing), speaking, and swallowing. The mandible is a U-shaped bone that consists of a horizontal part called the body and two vertical parts called rami.
The mandible articulates with the skull at the temporomandibular joints (TMJs) located in front of each ear, allowing for movements like opening and closing the mouth, protrusion, retraction, and side-to-side movement. The mandible contains the lower teeth sockets called alveolar processes, which hold the lower teeth in place.
In medical terminology, the term "mandible" refers specifically to this bone and its associated structures.
Root resorption is a process that occurs when the body's own cells, called odontoclasts, break down and destroy the hard tissue of the tooth root. This can occur as a result of various factors such as trauma, infection, or orthodontic treatment. In some cases, it may be a normal part of the tooth development and eruption process in children. However, excessive or pathological root resorption can lead to weakening and loss of the tooth. It is often asymptomatic and discovered during routine dental x-rays.
Multiple primary neoplasms refer to the occurrence of more than one primary malignant tumor in an individual, where each tumor is unrelated to the other and originates from separate cells or organs. This differs from metastatic cancer, where a single malignancy spreads to multiple sites in the body. Multiple primary neoplasms can be synchronous (occurring at the same time) or metachronous (occurring at different times). The risk of developing multiple primary neoplasms increases with age and is associated with certain genetic predispositions, environmental factors, and lifestyle choices such as smoking and alcohol consumption.
Keratins are a type of fibrous structural proteins that constitute the main component of the integumentary system, which includes the hair, nails, and skin of vertebrates. They are also found in other tissues such as horns, hooves, feathers, and reptilian scales. Keratins are insoluble proteins that provide strength, rigidity, and protection to these structures.
Keratins are classified into two types: soft keratins (Type I) and hard keratins (Type II). Soft keratins are found in the skin and simple epithelial tissues, while hard keratins are present in structures like hair, nails, horns, and hooves.
Keratin proteins have a complex structure consisting of several domains, including an alpha-helical domain, beta-pleated sheet domain, and a non-repetitive domain. These domains provide keratin with its unique properties, such as resistance to heat, chemicals, and mechanical stress.
In summary, keratins are fibrous structural proteins that play a crucial role in providing strength, rigidity, and protection to various tissues in the body.
Retrospective studies, also known as retrospective research or looking back studies, are a type of observational study that examines data from the past to draw conclusions about possible causal relationships between risk factors and outcomes. In these studies, researchers analyze existing records, medical charts, or previously collected data to test a hypothesis or answer a specific research question.
Retrospective studies can be useful for generating hypotheses and identifying trends, but they have limitations compared to prospective studies, which follow participants forward in time from exposure to outcome. Retrospective studies are subject to biases such as recall bias, selection bias, and information bias, which can affect the validity of the results. Therefore, retrospective studies should be interpreted with caution and used primarily to generate hypotheses for further testing in prospective studies.
A Biological Specimen Bank, also known as a biobank or tissue bank, is a type of medical facility that collects, stores, and distributes biological samples for research purposes. These samples can include tissues, cells, DNA, blood, and other bodily fluids, and are often collected during medical procedures or from donors who have given their informed consent. The samples are then cataloged and stored in specialized conditions to preserve their quality and integrity.
Biobanks play a critical role in advancing medical research by providing researchers with access to large numbers of well-characterized biological samples. This allows them to study the underlying causes of diseases, develop new diagnostic tests and treatments, and evaluate the safety and effectiveness of drugs and other therapies. Biobanks may be established for specific research projects or as part of larger, more comprehensive efforts to build biomedical research infrastructure.
It is important to note that the use of biological specimens in research is subject to strict ethical guidelines and regulations, which are designed to protect the privacy and interests of donors and ensure that the samples are used responsibly and for legitimate scientific purposes.
Immunohistochemistry (IHC) is a technique used in pathology and laboratory medicine to identify specific proteins or antigens in tissue sections. It combines the principles of immunology and histology to detect the presence and location of these target molecules within cells and tissues. This technique utilizes antibodies that are specific to the protein or antigen of interest, which are then tagged with a detection system such as a chromogen or fluorophore. The stained tissue sections can be examined under a microscope, allowing for the visualization and analysis of the distribution and expression patterns of the target molecule in the context of the tissue architecture. Immunohistochemistry is widely used in diagnostic pathology to help identify various diseases, including cancer, infectious diseases, and immune-mediated disorders.
The Ki-67 antigen is a cellular protein that is expressed in all active phases of the cell cycle (G1, S, G2, and M), but not in the resting phase (G0). It is often used as a marker for cell proliferation and can be found in high concentrations in rapidly dividing cells. Immunohistochemical staining for Ki-67 can help to determine the growth fraction of a group of cells, which can be useful in the diagnosis and prognosis of various malignancies, including cancer. The level of Ki-67 expression is often associated with the aggressiveness of the tumor and its response to treatment.
Squamous odontogenic tumor
Index of oral health and dental articles
Odontogenic keratocyst
Toothache
Odontogenic tumor
Odontogenic cyst
Basal-cell carcinoma
Myxoma
Craniopharyngioma
List of MeSH codes (C04)
Veterinary dentistry
Calcifying odontogenic cyst
Lateral periodontal cyst
SPRR3
Cysts of the jaws
Stafne defect
Dentigerous cyst
International Classification of Diseases for Oncology
Hereditary cancer syndrome
Oral medicine
Catenin beta-1
Squamous odontogenic tumor - Wikipedia
Maxillary dentigerous cyst showing squamous odontogenic tumor-like proliferation: surgical approach and literature review
Sandra Taylor<...
Acanthomatous Ameloblastoma: An Early Stage Case Report with Difficult Management
nct02834013 : Nevada NCORP
Shanmukha Ramya | OMICS International
Pesquisa | BVS Odontologia
Craniopharyngioma Pathology: Definition, Epidemiology, Etiology
Code System Concept
Chapter 15: Odontogenic Cysts and Tumors Flashcards - Easy Notecards
Dentosphere : World of Dentistry: April 2017
Odontogenic tumours and cysts - Libre Pathology
okvet [Veterinary Oral Diagnostic Imaging]
Cancer Diagnosis & Prognosis
A 7-year retrospective study of biopsied oral lesions in 460 Iranian patients
adeno-, aden- (gland, glandular) words: adenalgia to anadenia, part 1 of 2.
Archives of Craniofacial Surgery
Why Does My Pet Have Bad Breath? - Towne Centre Animal Hospital
UC Irvine PEComa Clinical Trials for 2023 - Orange County, CA
Combined Bachelor's + Master's degree in Medicine and Surgery - University of Verona
University of California Health Endometrial Cancer Clinical Trials for 2023 - California
UC Irvine Ovarian Cancer Clinical Trials for 2023 - Orange County, CA
Diagnosing and Treating Oral Tumors in Cats & Dogs
What to do for my dog's bad breath? - Northern Cascades
Awards - North American Society of Head and Neck Pathology
MeSH Browser
Soft Tissue Tumors | Basicmedical Key
Reconstruction of mandibular defects - clinical retrospective research over a 10-year period - | Head & Neck Oncology | Full...
tumor
Carcinoma37
- Squamous cell carcinoma arising in a residual odontogenic cyst: case report. (autopsyandcasereports.org)
- 14 Oliveira JA, Costa IM, Loyola AM. Squamous odontogenic tumor-like proliferations (SOT-LP) versus intraosseous squamous cell carcinoma in residual cyst. (autopsyandcasereports.org)
- Oral malignant melanoma, oral squamous cell carcinoma, and T3 tumors had the highest prevalence of metastatic disease at the time of staging. (avma.org)
- Epithelial tumors of nasal cavity, sinuses, nasopharynx: A) Squamous cell carcinoma with variants of nasal cavity, sinuses, and nasopharynx and trachea (excluding laryngeal, nasopharyngeal cancer [NPC], and squamous cell carcinoma of the head and neck [SCCHN]) B) Adenocarcinoma and variants of nasal cavity, sinuses, and nasopharynx (closed to accrual 07/27/2018) 2. (sncrf.org)
- Squamous cell carcinoma with variants of GI tract (stomach small intestine, colon, rectum, pancreas) (closed to accrual 10/17/2018) 7. (sncrf.org)
- Rare pancreatic tumors including acinar cell carcinoma, mucinous cystadenocarcinoma or serous cystadenocarcinoma. (sncrf.org)
- Epithelial tumors of penis - squamous adenocarcinoma cell carcinoma with variants of penis (closed to accrual) 18. (sncrf.org)
- Squamous cell carcinoma variants of the genitourinary (GU) system 19. (sncrf.org)
- Pancreatic neuroendocrine tumor (PNET) (formerly named: Endocrine carcinoma of pancreas and digestive tract. (sncrf.org)
- The vast majority of oral malignancies are squamous cell carcinoma . (librepathology.org)
- Complete removal - as may transform to squamous cell carcinoma or ameloblastoma . (librepathology.org)
- Periapical cysts (PCs) belong to the inflammatory odontogenic cysts sub-category and rarely squamous cell carcinoma arises from their hyperplastic/ dysplastic epithelia. (cancerdiagnosisprognosis.org)
- These histopathological characteristics rarely form an eligible substrate for squamous cell carcinoma onset in untended cases. (cancerdiagnosisprognosis.org)
- Although rare, primary intraosseous squamous cell carcinoma arises from their hyperplastic/dysplastic epithelia in untended, misdiagnosed cases ( Oral Surg Oral Med Oral Pathol Oral Radiol 120(5) (2015)">3 , J Cancer Res Ther 16(3) (2020)">4 ). (cancerdiagnosisprognosis.org)
- The most common oral tumors in pets are melanoma, squamous cell carcinoma, and odontogenic fibromas. (townecentrevet.com)
- This phase II trial studies how well Ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor AZD6738 works alone or in combination with olaparib or durvalumab in treating participants with renal cell carcinoma (RCC), urothelial carcinoma, all pancreatic cancers, endometrial cancer, and other solid tumors excluding clear cell ovarian cancer that have spread to nearby tissue or lymph nodes or other parts of the body. (ucbraid.org)
- Malignant melanoma, squamous cell carcinoma, and fibrosarcoma are the most common. (animaldentalaz.com)
- The malignant oral neoplasms are diagnosed in 32-37% of cases, with squamous cell carcinoma being the most frequent, followed by fibrosarcoma, osteosarcoma and malignant melanoma. (animaldentalaz.com)
- Variability in the Depth of Invasion Measurements of Oral Tongue Squamous Cell Carcinoma and the Effect on Pathologic T-Staging. (headandneckpathology.com)
- Caltabiano R, Cappellani A, Di Vita M, Lanzafame S. The unique simultaneous occurrence of a squamous cell carcinoma and a granular cell tumor of the tongue at the same site: a histological and immunohistochemical study. (medscape.com)
- Podoplanin expression in oral squamous cell carcinoma has been associated with the presence of lymph node metastasis and worst patient prognosis. (fapesp.br)
- The sample will be constituted of 100 patients with oral squamous cell carcinoma on the lower lip, clinical stages I, II and III, treated in the Department of Head and Neck Surgery and Othorhinolaryngology of the A.C. Camargo Hospital, São Paulo, from 1970 to 2008. (fapesp.br)
- An aggressive variant of cervical squamous cell carcinoma characterized by the presence of nests of malignant basaloid squamous cells with scant amount of cytoplasm. (nih.gov)
- Basaloid squamous cell carcinoma of the head and neck: clinicopathological features and differential diagnosis. (nih.gov)
- Basaloid squamous cell carcinoma of the head and neck. (nih.gov)
- Significance of SOX2 in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma: An Immunohistochemical Study. (annoordentalcollege.org)
- Immunohistochemical Expression of Fascin in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma. (annoordentalcollege.org)
- Immunohistochemical expression of cyclooxygenase-2 in oral squamous cell carcinoma. (annoordentalcollege.org)
- Expression levels of RANKL assessed by western blotting were markedly lower in ameloblastoma (AM-1) cells than in highly metastatic oral squamous cell carcinoma (HSC-3) cells. (elsevierpure.com)
- Basal cell carcinoma (BCC) is a nonmelanocytic skin cancer (ie, an epithelial tumor) that arises from basal cells (ie, small, round cells found in the lower layer of the epidermis). (medscape.com)
- The most common tumor of the mandible and maxilla is squamous cell carcinoma invading the bone through dental sockets. (msdmanuals.com)
- Paranasal sinus squamous cell carcinoma incidence and survival based on Surveillance, Epidemiology, and End Results data, 1973 to 2009. (ucdenver.edu)
- Ogawa K, Toita T, Kakinohana Y, Adachi G, Kojya S, Itokazu T, Shinhama A, Matsumura J, Murayama S. Postoperative radiotherapy for squamous cell carcinoma of the maxillary sinus: analysis of local control and late complications. (ucdenver.edu)
- Genetic factors play a role in the development of cutaneous squamous-cell carcinoma. (cdc.gov)
- Inherited phenotypic characteristics - such as light skin, red or blonde hair, and light-colored eyes - are associated with an increased risk of cutaneous squamous-cell carcinoma. (cdc.gov)
- A family history of cutaneous squamous-cell carcinoma is associated with a risk that is two to four times that in persons without a family history. (cdc.gov)
- Inherited disorders such as xeroderma pigmentosum also increase the risk of cutaneous squamous-cell carcinoma, often with an earlier age at onset. (cdc.gov)
Cysts16
- In rare cases, squamous odontogenic tumor-like proliferation (SOT-LP) can be observed arising from odontogenic cysts (SOT-LPOC). (autopsyandcasereports.org)
- Squamous odontogenic tumor and squamous odontogenic tumor-like proliferations in odontogenic cysts: an updated analysis of 170 cases reported in the literature. (autopsyandcasereports.org)
- Squamous odontogenic tumor-like proliferations in radicular cysts: a clinicopathologic study of forty-two cases. (autopsyandcasereports.org)
- 5 Wright JM Jr. Squamous odontogenic tumorlike proliferations in odontogenic cysts. (autopsyandcasereports.org)
- Squamous odontogenic tumors arising in odontogenic cysts. (autopsyandcasereports.org)
- Squamous odontogenic tumor-like proliferations in periapical cysts. (autopsyandcasereports.org)
- What are the two classes of odontogenic cysts? (easynotecards.com)
- Most Common Sites of Some Important Pathologies : Oral Cancer, Cysts, Tumors etc. (dentaldevotee.com)
- This article covers odontogenic tumours and cysts , which is a subset of oral pathology and can be grouped under the heading of head and neck pathology . (librepathology.org)
- Common odontogenic cysts are dentigerous cysts , and radicular cysts . (librepathology.org)
- Metastases in odontogenic cysts: literature review and case presentation. (librepathology.org)
- Morphologic analysis of odontogenic cysts with computed tomography. (librepathology.org)
- Neoplastic potential of odontogenic cysts. (librepathology.org)
- Background/Aim: Odontogenic cysts belong to a type of lesions with endodontic origin that in some cases mimic even aggressive odontogenic tumors sharing with them similar radiographic features. (cancerdiagnosisprognosis.org)
- Among lesions with endodontic origin, odontogenic cysts are frequently identified and clinically categorized as developmental and inflammatory ( StatPearls [Internet] (2022)">1 ). (cancerdiagnosisprognosis.org)
- The most frequent lesions were in the group of reactive lesions (22.51%), followed by odontogenic cysts. (bvsalud.org)
Epithelium10
- Lesions are non-encapsulated with islands of well differentiated squamous epithelium that commonly contain microcysts and calcifications in a dense fibrous connective tissue stroma. (wikipedia.org)
- Microscopically, SOT shows islands of squamous epithelium supported by fibrous stroma. (autopsyandcasereports.org)
- [ 12 ] Complex sellar lesions consisting of pituitary adenoma intimately admixed with Rathke cyst and metaplastic squamous epithelium have also been reported. (medscape.com)
- Transforms into squamous epithelium. (librepathology.org)
- Squamous epithelium - non-keratinized - important . (librepathology.org)
- Keratocystic odontogenic tumour - keratinized epithelium. (librepathology.org)
- Squamous epithelium. (librepathology.org)
- Histologically, PCs demonstrate a non-keratinized stratified squamous epithelium as a formation of one or two thin cell layers combined with fibrous connective tissue substrate infiltrated by inflammatory cells. (cancerdiagnosisprognosis.org)
- The Odontogenic Keratocyst is known for its aggressiveness, high recurrence rate and transformation of keratinized epithelia to non-keratinized squamous epithelium for which inflammation has been suggested to be responsible. (uwi.edu)
- The masses were covered with a thin stratified squamous epithelium. (biomedcentral.com)
Ameloblastoma6
- Ameloblastoma belongs to the benign epithelial odontogenic tumor subgroup, and it is probably one of the most controversial and enigmatic tumors of the facial skeleton, due to both clinical behavior and histological features [ 1 - 10 ]. (hindawi.com)
- Acanthomatous ameloblastoma (AA) also presents histological features very similar to those of the squamous odontogenic tumor from which it differs since the peripheral cells are columnar instead of flat [ 9 ]. (hindawi.com)
- A View of Adenomatoid Odontogenic Tumor in Ameloblastoma: A Hybrid Variant. (annoordentalcollege.org)
- Ameloblastoma is the most common benign odontogenic tumor in Japan. (elsevierpure.com)
- Ameloblastoma and adenomatoid odontogenic tumor: the role of alpha2beta1, alpha3beta1, and alpha5beta1 integrins in local invasiveness and architectural characteristics. (ufrn.br)
- Ameloblastoma, the most common epithelial odontogenic tumor, usually arises in the posterior mandible. (msdmanuals.com)
Keratocyst4
- The cyst was excised, and histopathologic examination revealed an odontogenic keratocyst (OKC). (easynotecards.com)
- There is debate over reclassification of the odontogenic keratocyst (OKC) as keratocystic odontogenic tumor (KCOT). (easynotecards.com)
- The most frequent lesion was radicular cyst and odontogenic keratocyst (keratocystic odontogenic tumor). (bvsalud.org)
- The results showed high frequency of odontogenic keratocyst (keratocystic odontogenic tumor) which is not in agreement with other studies and need more evaluation of etiological factors. (bvsalud.org)
Lesions2
- These lesions can be confused with oral tumors and should be diagnosed as soon as possible after being noticed. (animaldentalaz.com)
- Epulis is a non-specific term connoting a tumour-like mass of the gingiva and the term is used in association with several different gingival lesions, regardless of their aetiology or histogenesis [ 1 ]. (biomedcentral.com)
Cyst4
- 9 Sala-Pérez S, Marco-Molina V, Gay-Escoda C. Squamous odontogenic tumor-like proliferation in a radicular cyst: a case report. (autopsyandcasereports.org)
- 11 Unal T, Gomel M, Gunel O. Squamous odontogenic tumor-like islands in a radicular cyst: report of a case. (autopsyandcasereports.org)
- The close histopathologic and immunohistochemical resemblance among adamantinomatous craniopharyngioma, adamantinoma of the jaw, and calcifying odontogenic cyst suggests an odontogenic epithelial differentiation for these tumors. (medscape.com)
- What is the most common type of developmental odontogenic cyst? (easynotecards.com)
Carcinomas5
- Histologic predictors of response to neoadjuvant PD1 inhibitor therapy in advanced stage HPV-negative head and neck squamous cell carcinomas. (headandneckpathology.com)
- Primary and recurrent head and neck squamous carcinomas are strikingly different regarding their immune microenvironment. (headandneckpathology.com)
- How phenotype guides management of non-conventional squamous cell carcinomas of the larynx? (nih.gov)
- 90% of head and neck cancers are squamous cell (epidermoid) carcinomas. (msdmanuals.com)
- The incidence of keratinocyte cancer (basal cell and squamous cell carcinomas of the skin) is 17-fold lower in Singapore than the UK, despite Singapore receiving 2-3 times more ultraviolet (UV) radiation. (cdc.gov)
Patients with advanced solid tumors2
- This is a Phase 1/2, multi-center, open-label, dose-escalation and expansion study to evaluate safety and tolerability, PK, pharmacodynamic, and early signal of anti-tumor activity of MDNA11 alone or in combination with a checkpoint inhibitor in patients with advanced solid tumors. (ucbraid.org)
- This is an open-label, two-part, phase 1-2 dose-finding study designed to determine the safety, tolerability, PK, PD, and proof-of-concept efficacy of ST101 administered IV in patients with advanced solid tumors. (ucbraid.org)
Neoplasms1
- Squamous odontogenic tumors (SOTs) are very rare benign locally infiltrative odontogenic neoplasms of epithelial origin. (wikipedia.org)
Epithelial odontogenic tumor2
- Clear cell calcifying epithelial odontogenic tumor. (bvsalud.org)
- Maxillary calcifying epithelial odontogenic tumor. (annoordentalcollege.org)
Myxoma1
- Odontogenic myxoma with orbital involvement. (ucdenver.edu)
Solid tumors5
- This phase I trial identifies the best dose, possible benefits and/or side effects of BAY 1895344 in combination with chemotherapy in treating patients with solid tumors or urothelial cancer that has spread to other places in the body (advanced). (ucbraid.org)
- Combining BAY 1895344 with chemotherapy treatment (cisplatin, or cisplatin and gemcitabine) may be effective for the treatment of advanced solid tumors, including urothelial cancer. (ucbraid.org)
- This is a Phase 1, multiple dose, ascending dose escalation study to define a MTD/RD and regimen of XmAb23104, to describe safety and tolerability, to assess PK and immunogenicity, and to preliminarily assess anti-tumor activity of XmAb23104 monotherapy and combination therapy with ipilimumab in subjects with selected advanced solid tumors. (ucbraid.org)
- This clinical trial is evaluating a drug called BT5528 alone and in combination with nivolumab in participants with advanced solid tumors historically known for expression of EphA2. (uci.edu)
- I. To evaluate the Response Evaluation Criteria in Solid Tumors (RECIST) version (v)1.1 overall response rate (ORR) in subsets of patients with advanced rare cancers treated with ipilimumab plus nivolumab combination immunotherapy. (clinicaltrialsgps.com)
Cell22
- Non-epithelial tumors of the ovary: A) Germ cell tumor of ovary B) Mullerian mixed tumor and adenosarcoma (closed to accrual 03/30/2018) 14. (sncrf.org)
- Cell tumor of the testes and extragonadal germ tumors: A) Seminoma and testicular sex cord cancer B) Non seminomatous tumor C) Teratoma with malignant transformation (closed to accrual) 17. (sncrf.org)
- Malignant giant cell tumors 30. (sncrf.org)
- Perivascular epithelioid cell tumor (PEComa) 39. (sncrf.org)
- 1. A benign tumor of glandular origin or with a gland-like cell arrangement. (wordquests.info)
- BAY 1895344 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. (ucbraid.org)
- e The pattern listed is for the spindled cell component of the tumor. (basicmedicalkey.com)
- Vered M, Carpenter WM, Buchner A. Granular cell tumor of the oral cavity: updated immunohistochemical profile. (medscape.com)
- Granular cell tumor: a review and update. (medscape.com)
- Eagle syndrome produced by a granular cell tumor. (medscape.com)
- Granular cell tumor of the tongue in a 6-year-old girl--a case report. (medscape.com)
- Multiple granular cell tumor: a case report and review of the literature. (medscape.com)
- Dive A, Dhobley A, Fande PZ, Dixit S. Granular cell tumor of the tongue: Report of a case. (medscape.com)
- Granular cell tumor: immunohistochemical assessment of inhibin-alpha, protein gene product 9.5, S100 protein, CD68, and Ki-67 proliferative index with clinical correlation. (medscape.com)
- Oral granular cell tumors: a clinicopathologic and immunocytochemical study. (medscape.com)
- Freitas VS, dos Santos JN, Oliveira MC, Santos PP, Freitas Rde A, de Souza LB. Intraoral granular cell tumors: clinicopathologic and immunohistochemical study. (medscape.com)
- Clinical photograph of a granular cell tumor on the tongue of a 38-year-old man. (medscape.com)
- Granular cell tumor. (medscape.com)
- Congenital oral granular cell tumour of the newborn is an uncommon benign tumour of uncertain origin. (biomedcentral.com)
- The diagnosis was congenital granular cell tumour. (biomedcentral.com)
- Congenital oral granular cell tumour occurs almost exclusively in Caucasian newborns but also rarely in black infants. (biomedcentral.com)
- The differential diagnosis included congenital granular cell tumour (CGCT), odontogenic tumour, teratoma, neuroectodermal tumour, haemangioma and fibroma with a provisional diagnosis of CGCT. (biomedcentral.com)
Mesenchymal4
- Benign tumour of mesenchymal origin. (librepathology.org)
- A mixed tumor of odontogenic origin, in which both the epithelial and mesenchymal cells exhibit complete differentiation, resulting in the formation of tooth structures. (uchicago.edu)
- Context: Mesenchymal odontogenic tumors arise from the remnants of the mesenchymal portion of tooth germ. (amhsr.org)
- Malignant mesenchymal tumors of the head and neck. (umfhs.rs)
Common odontogenic2
- Most common odontogenic tumour - considered to be a hamartoma . (librepathology.org)
- Odontoma, the most common odontogenic tumor, affects the dental follicle or the dental tissues and usually appears in the mandibles of young people. (msdmanuals.com)
Adenomatoid1
- adenomatoid odontogenic t. (en-academic.com)
Stop the growth of tumor cells2
- Cisplatin and gemcitabine are chemotherapy drugs that stop the growth of tumor cells by killing the cells. (ucbraid.org)
- Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. (ucbraid.org)
Clinically3
- The en bloc excision of the lesion was directly performed under local anesthesia and after antibiotic prophylactic regimen (amoxicillin+clavulanic acid, 2 gr p. os, 1 hour before surgery) involving the overlying keratinized tissue and the 2 contiguous teeth, with a few millimeters of lateral and apical clinically healthy tissue and about 2 mm of residual bone cavity curettage. (hindawi.com)
- Conversely, oral tumors can present clinically as an ulcer or a non-healing extraction site, and not with a typical lump-like lesion. (animaldentalaz.com)
- If not initially detected on x-ray, jaw tumors are diagnosed clinically because their growth causes swelling of the face, palate, or alveolar ridge (the part of the jaw supporting the teeth). (msdmanuals.com)
Peripheral2
- Management of a rare case of peripheral squamous odontogenic tumor of the gingiva. (autopsyandcasereports.org)
- Peripheral nerve sheath tumors and NF1-related tumors (closed to accrual 09/19/2018) 29. (sncrf.org)
Differentiation2
- In order to evaluate different neo-angiogenesis levels inside malignant tissues derived from oral and odontogenic epithelia, many studies have focused on cluster differentiation 34 (CD34) protein expression combined with micro vessel density (MVD) in them ( Asian Pac J Cancer Prev 12(2) (2011)">5 - Acta Odontol Scand 68(5) (2010)">9 ). (cancerdiagnosisprognosis.org)
- An adenocarcinoma in which some or the majority of the cells exhibit squamous differentiation. (wordquests.info)
Head and neck4
- Salivary gland type tumors of head and neck, lip, esophagus, stomach, trachea and lung, breast and other location (closed to accrual) 4. (sncrf.org)
- Overview of Head and Neck Tumors Head and neck cancer develops in almost 65,000 people in the United States each year. (msdmanuals.com)
- The head and neck regions were constituted to have high anatomical and functional difficulties, making the accurate diagnosis and staging of regional tumors a challenging task. (springeropen.com)
- MRI sequences provided us with very accurate data about tumor size, site, and morphological criteria of tumors in the head and neck areas. (springeropen.com)
Odontoma1
- Complex odontoma - disorganized mass of odontogenic tissues. (librepathology.org)
Cortical tumors1
- Adrenal cortical tumors (closed to accrual 06/27/2018) 32. (sncrf.org)
Tumours1
- Mixed odontogenic tumours and odontomas. (bvsalud.org)
Rare Tumors2
- This phase II trial studies nivolumab and ipilimumab in treating patients with rare tumors. (sncrf.org)
- Not Otherwise Categorized (NOC) Rare Tumors [To obtain permission to enroll in the NOC cohort, contact: [email protected]] (closed to accrual 03/15/2019) 34. (sncrf.org)
EXCISION1
- Benign tumors may be observed and may not need surgical excision, although most tumors require resection with possible reconstruction. (msdmanuals.com)
Closed to accrual6
- Epithelial tumors of major salivary glands (closed to accrual 03/20/2018) 3. (sncrf.org)
- Extrahepatic cholangiocarcinoma and bile duct tumors (closed to accrual 03/20/2018) 11. (sncrf.org)
- Trophoblastic tumor: A) Choriocarcinoma (closed to accrual) 15. (sncrf.org)
- Gastrointestinal stromal tumor (GIST) (closed to accrual 09/26/2018) 38. (sncrf.org)
- Apocrine tumors/extramammary Paget's disease (closed to accrual) 40. (uci.edu)
- Endometrial carcinosarcoma (malignant mixed Mullerian tumors) (closed to accrual) 45. (uci.edu)
Tissue7
- 1. A tumor composed of connective tissue containing glandular structures. (wordquests.info)
- Oral tumors - Most common in older pets, oral tumors can become infected and tissue necrosis can occur, leading to a persistent foul odor. (townecentrevet.com)
- Even though a benign tumor is not necessarily fatal, it can have an aggressive growth pattern and can cause severe tissue damage and pain. (animaldentalaz.com)
- All categories of soft tissue tumors have been reported to involve the upper aerodigestive tract. (basicmedicalkey.com)
- These tumors have markedly different prognoses and require different treatments than those for soft tissue tumors. (basicmedicalkey.com)
- Fibroblastic or myofibroblastic tumors make up the majority of soft tissue tumors of the aerodigestive tract and range from nonneoplastic or benign proliferations (fibromas) to high-grade malignancies (undifferentiated high-grade pleomorphic sarcomas). (basicmedicalkey.com)
- I. To evaluate the association of tumor mutational burden measured by tissue sequencing with durable response (complete response [CR] or partial response [PR] lasting 24 weeks or more). (clinicaltrialsgps.com)
Diagnosis2
- Squamous Odontogenic Tumor: Literature Review Focusing on the Radiographic Features and Differential Diagnosis. (wikipedia.org)
- Typically, these tumors are excised, particularly when the diagnosis is in doubt. (msdmanuals.com)
Congenital1
- Congenital epulis is an uncommon benign gingival tumour of the newborn. (biomedcentral.com)
Metastasis2
- Lymph node metastasis was diagnosed with CT or cytology in 7.5% of cases (10.7% of nonodontogenic tumors, 0% of odontogenic tumors). (avma.org)
- Lymphatic metastasis was diagnosed in 10.7% of nonodontogenic tumors, but cytology was not performed in the majority of cases and often included only a single mandibular node. (avma.org)
Pathology1
- In dogs , malignant tumors were the most diagnosed pathology in biopsy samples submitted to the lab, found in about 37% of cases. (animaldentalaz.com)
Benign tumor2
- 2. A benign tumor with the structure or appearance of a gland or originating in a gland. (wordquests.info)
- A benign tumor is one that has a slower growth rate and does not metastasize to the regional lymph nodes or other organs. (animaldentalaz.com)
Arises1
- Squamous odontogenic tumor (SOT) is a rare benign neoplasm of the jaw that likely arises from remnants of the dental lamina. (autopsyandcasereports.org)
Oral cavity1
- some tumors are discovered on routine dental x-rays, whereas others are found on routine examinations of the oral cavity and teeth. (msdmanuals.com)
Metaplasia1
- In elderly persons, squamous metaplasia of adenohypophyseal cells of the pituitary stalk or gland has been postulated as a possible origin for the papillary variant of craniopharyngioma. (medscape.com)
Maxillary Sinus1
- Tumors or cancer of the MAXILLARY SINUS. (ucdenver.edu)
Bone2
- Bone lysis was present in 74.4% of tumors. (avma.org)
- bone and cartilagenous tumors will be discussed in Chapter 12 ). (basicmedicalkey.com)
Radiographic Features1
- Interestingly, in some cases they mimic odontogenic tumors due to similar and non-discriminating radiographic features. (cancerdiagnosisprognosis.org)
Aggressive1
- Postoperative radiation can also be a useful adjunct when patients have aggressive tumors that were treated surgically or when surgery has failed to clear the margins of the tumor. (medscape.com)