Oldenlandia
Cyclotides
Rubiaceae
Chiropractic
Manipulation, Chiropractic
Hospital Shared Services
Vitamin A
Research
Vitamin D
Induction of nitric oxide synthase by Oldenlandia diffusa in mouse peritoneal macrophages. (1/21)
Oldenlandia diffusa (OD) has been used to treat malignant tumors. In this study using mouse peritoneal macrophages, we have examined the mechanism by which OD regulates nitric oxide (NO) production. When OD (1 mg/ml) was used in combination with 10 U/ml of recombinant interferon-gamma (rIFN-gamma), there was a marked cooperative induction of NO production (36.13+/-7.12 microM) by the Griess method (nitrite). Treatment of macrophages with rIFN-gamma plus OD (1 mg/ml) caused a significant increase in tumor necrosis factor-alpha (TNF-alpha) production (4.49+/-1.43 ng/ml) by enzyme-linked immunosorbent assay. The increased production of NO and TNF-alpha from rIFN-gamma-plus OD-stimulated cells was almost completely inhibited by pretreatment with 100 microM of pyrrolidine dithiocarbamate (PDTC), an inhibitor of nuclear factor kappa B (NF-kappaB). PDTC also inhibited phosphorylation of IkappaB in rIFN-gamma-plus OD-stimulated cells. These findings demonstrate that OD increases the production of NO and TNF-alpha by rIFN-gamma-primed macrophages and suggest that NF-kappaB plays a critical role in mediating these effects of OD. (+info)Disulfide folding pathways of cystine knot proteins. Tying the knot within the circular backbone of the cyclotides. (2/21)
The plant cyclotides are a fascinating family of circular proteins that contain a cyclic cystine knot motif. The knotted topology and cyclic nature of the cyclotides pose interesting questions about folding mechanisms and how the knotted arrangement of disulfide bonds is formed. In the current study we have examined the oxidative refolding and reductive unfolding of the prototypic cyclotide, kalata B1. A stable two-disulfide intermediate accumulated during oxidative refolding but not in reductive unfolding. Mass spectrometry and NMR spectroscopy were used to show that the intermediate contained a native-like structure with two native disulfide bonds topologically similar to the intermediate isolated for the related cystine knot protein EETI-II (Le-Nguyen, D., Heitz, A., Chiche, L., El Hajji, M., and Castro B. (1993) Protein Sci. 2, 165-174). However, the folding intermediate observed for kalata B1 is not the immediate precursor of the three-disulfide native peptide and does not accumulate in the reductive unfolding process, in contrast to the intermediate observed for EETI-II. These alternative pathways of linear and cyclic cystine knot proteins appear to be related to the constraints imposed by the cyclic backbone of kalata B1 and the different ring size of the cystine knot. The three-dimensional structure of a synthetic version of the two-disulfide intermediate of kalata B1 in which Ala residues replace the reduced Cys residues provides a structural insight into why the two-disulfide intermediate is a kinetic trap on the folding pathway. (+info)Disulfide mapping of the cyclotide kalata B1. Chemical proof of the cystic cystine knot motif. (3/21)
The cyclotides are a recently discovered family of plant proteins that have the fascinating structural feature of a continuous cyclic backbone and, putatively, a knotted arrangement of their three conserved disulfide bonds. We here show definite chemical proof of the I-IV, II-V, III-VI knotted disulfide connectivity of the prototypic cyclotide kalata B1. This has been achieved by a new approach for disulfide analysis, involving partial reduction and stepwise alkylation including introduction of charges and enzymatic cleavage sites by aminoethylation of cysteines. The approach overcomes the intrinsic difficulties for disulfide mapping of cyclotides, i.e. the cyclic amide backbone, lack of cleavage sites between cysteines, and a low or clustered content of basic amino acids, and allowed a direct determination of the disulfide bonds in kalata B1 using analysis by mass spectrometry. The established disulfide connectivity is unequivocally shown to be cystine knotted by a topological analysis. This is the first direct chemical determination of disulfides in native cyclotides and unambiguously confirms the unique cyclic cystine knot motif. (+info)Clinical observation in 86 cases of acne vulgaris treated with Compound Oldenlandis Mixture. (4/21)
86 cases of acne vulgaris were treated with Fu Fang She She Cao He Ji ([symbol: see text] Compound Oldenlandis Mixture), with the other 34 cases treated with Dang Gui Ku Shen Wan ([symbol: see text] Pills Prepared from Chinese Angelica and Flavescent Sophora Root) as the controls, to observe the therapeutic effect of the former. The results showed that the cure plus markedly effective rate was 73.26% in the treatment group, and 47.06% in the control group, with a significant difference in the cure plus markedly effective rate between the two groups (P < 0.01), and also in the total effective rate between the two groups significant (P < 0.05). It may be concluded that the Compound Oldenlandis Mixture is a better agent for the illness. (+info)Processing of a 22 kDa precursor protein to produce the circular protein tricyclon A. (5/21)
Cyclotides are a family of plant proteins that have the unusual combination of head-to-tail backbone cyclization and a cystine knot motif. They are exceptionally stable and show resistance to most chemical, physical, and enzymatic treatments. The structure of tricyclon A, a previously unreported cyclotide, is described here. In this structure, a loop that is disordered in other cyclotides forms a beta sheet that protrudes from the globular core. This study indicates that the cyclotide fold is amenable to the introduction of a range of structural elements without affecting the cystine knot core of the protein, which is essential for the stability of the cyclotides. Tricyclon A does not possess a hydrophobic patch, typical of other cyclotides, and has minimal hemolytic activity, making it suitable for pharmaceutical applications. The 22 kDa precursor protein of tricyclon A was identified and provides clues to the processing of these fascinating miniproteins. (+info)Kalata B8, a novel antiviral circular protein, exhibits conformational flexibility in the cystine knot motif. (6/21)
The cyclotides are a family of circular proteins with a range of biological activities and potential pharmaceutical and agricultural applications. The biosynthetic mechanism of cyclization is unknown and the discovery of novel sequences may assist in achieving this goal. In the present study, we have isolated a new cyclotide from Oldenlandia affinis, kalata B8, which appears to be a hybrid of the two major subfamilies (Mobius and bracelet) of currently known cyclotides. We have determined the three-dimensional structure of kalata B8 and observed broadening of resonances directly involved in the cystine knot motif, suggesting flexibility in this region despite it being the core structural element of the cyclotides. The cystine knot motif is widespread throughout Nature and inherently stable, making this apparent flexibility a surprising result. Furthermore, there appears to be isomerization of the peptide backbone at an Asp-Gly sequence in the region involved in the cyclization process. Interestingly, such isomerization has been previously characterized in related cyclic knottins from Momordica cochinchinensis that have no sequence similarity to kalata B8 apart from the six conserved cysteine residues and may result from a common mechanism of cyclization. Kalata B8 also provides insight into the structure-activity relationships of cyclotides as it displays anti-HIV activity but lacks haemolytic activity. The 'uncoupling' of these two activities has not previously been observed for the cyclotides and may be related to the unusual hydrophilic nature of the peptide. (+info)Determination of iridoid glucosides for quality assessment of Herba Oldenlandiae by high-performance liquid chromatography. (7/21)
Herba Oldenlandiae, the dried herb of Oldenlandia diffusa (WILLD.) ROXB. (Family Rubiaceae), is officially listed in the Chinese Pharmacopoeia. In the herbal market, two substitutes originated from O. corymbosa (L.) LAM and O. tenelliflora BL. are commonly used. In light of this, the target in setting up a method for quality assessment of Herba Oldenlandiae is urgently needed. In this article, a simple and reliable high-performance liquid chromatographic (HPLC) method was developed for quantifying asperuloside (1), E-6-O-p-coumaroyl scandoside methyl ester (2) and E-6-O-p-coumaroyl scandoside methyl ester-10-methyl ether (3) in Herba Oldenlandiae derived from O. diffusa. Among them, compound 3 is a new compound isolated from O. diffusa. All these unique compounds were used as markers for the first time in the quality assessment of Herba Oldenlandiae. The results showed that the contents of compounds 1-3 were significantly varied among different samples whilst those of compounds 2 and 3 were found to be lower in contents in the two substitutes of O. diffusa. The analytical method is suitable for quality control of Herba Oldenlandiae and useful in differentiation from its confusable species. The method has been fully validated with satisfactory linearity, accuracy, precision and stability. (+info)Evidence for Oldenlandia diffusa-evoked cancer cell apoptosis through superoxide burst and caspase activation. (8/21)
BACKGROUND & OBJECTIVE: Oldenlandia diffusa (Bai Hua She She Cao) is one of the herbs most commonly used in traditional Chinese medicine for treating cancer. Various studies using the herb alone or in combination with other therapy plans have evidenced the effectiveness of the herb in the management of cancers of different tissue origin. However, the mechanisms underlying its anti-cancer activity are unknown. In the present study, we attempted to investigate the apoptotic activity of crude extracts of the herb as well as the possible molecular pathways. METHODS: We incubated human promyelocytic leukemia cell line HL60 cells with ethanol or aqueous extracts of the herb, and determined the levels of intracellular superoxide at 2 and 4 hours as well as caspase activity at 3, 6 and 8 hours using photospectrometry. Cancer cell survival and apoptosis were quantified at 24 hours by using MTT and flow cytometry analyses respectively. RESULTS: We found that it dose-dependently inhibited the cancer cell growth in MTT assay. Flow cytometry analysis revealed that it elicited significant production of sub-G(1) population of the cells, indicating the extract-evoked cell apoptotic death. The LD(50) of the ethanol extract was estimated to be approximately 320 microg/ml. Moreover, treatment of the cancer cells with the ethanol component markedly increased the production of superoxide within few hours. Significant elevation in the protease activities of caspases-2 and -3 were detected at as early as 3 and 6 hours respectively. CONCLUSION: Our results show that the ethanol extract of the herb effectively evokes cancer cell apoptosis, possibly through burst-mediated caspase activation. (+info)"Oldenlandia" is not a term that has a specific medical definition. It is a genus of flowering plants in the coffee family, Rubiaceae, and it includes over 200 species that are found primarily in tropical and subtropical regions around the world. Some species of Oldenlandia have been used in traditional medicine in various cultures, but there is limited scientific evidence to support their effectiveness or safety.
In modern medical contexts, if "Oldenlandia" is mentioned, it may refer to a specific plant species that has been studied for its potential medicinal properties. For example, Oldenlandia diffusa (also known as Hedyotis diffusa) has been investigated for its anti-inflammatory, antioxidant, and anticancer effects. However, it is important to note that the use of any plant or herbal remedy should be discussed with a qualified healthcare provider, as they can interact with other medications and have potential side effects.
Cyclotides are a group of naturally occurring cyclic peptides that contain a head-to-tail cyclized structure and a conserved cystine knot motif. They are produced by plants, particularly those in the Rubiaceae family, as a defense mechanism against herbivores and pathogens.
Cyclotides have unique structural features, including a circular arrangement of amino acids and a knotted pattern of disulfide bonds, which contribute to their stability and resistance to degradation. These properties make them attractive candidates for drug development and therapeutic applications.
In addition to their potential use as drugs, cyclotides have also been studied for their potential as insecticides, antimicrobial agents, and anti-cancer therapies. They have been shown to have potent activity against a variety of targets, including cancer cells, bacteria, fungi, and viruses.
Overall, the unique structural and functional properties of cyclotides make them an exciting area of research in the fields of medicinal chemistry, pharmacology, and drug discovery.
Rubiaceae is not a medical term, but a taxonomic category in botany. It refers to the family of flowering plants that includes more than 13,500 species, distributed across approximately 600 genera. Some well-known members of this family include coffee (Coffea arabica), gardenias (Gardenia jasminoides), and madder (Rubia tinctorum).
In a medical context, certain plants from the Rubiaceae family have been used in traditional medicine for various purposes. For example:
* Coffee (Coffea arabica) beans are used to prepare caffeinated beverages that can help with alertness and concentration.
* Gardenia fruits and flowers have been used in traditional Chinese medicine to treat anxiety, insomnia, and inflammation.
* Madder root (Rubia tinctorum) has been used as a dye and in traditional medicine to treat skin conditions and digestive disorders.
However, it's important to note that the medicinal use of plants from this family should be based on scientific evidence and under the guidance of healthcare professionals, as some of these plants can have side effects or interact with medications.
Chiropractic is a health care profession that focuses on the diagnosis, treatment, and prevention of disorders of the neuromusculoskeletal system, with an emphasis on the spine. Chiropractors use manual therapies, including spinal manipulation and adjustment, to realign the spine and improve function, reduce pain, and promote overall health and well-being.
The primary goal of chiropractic care is to correct subluxations, or misalignments of the vertebrae in the spine, which can cause nerve interference and affect the body's natural ability to heal itself. Chiropractors may also use other therapies such as exercise, nutrition counseling, and lifestyle modifications to help patients achieve optimal health and wellness.
Chiropractic is a drug-free and non-surgical approach to healthcare that is recognized by major regulatory bodies around the world. It has been shown to be effective for a wide range of conditions, including back pain, neck pain, headaches, and other musculoskeletal disorders.
Chiropractic manipulation, also known as spinal manipulative therapy, is a technique used by chiropractors to realign misaligned vertebrae in the spine (subluxations) with the goal of improving function, reducing nerve irritation, and alleviating pain. This technique involves using controlled force, direction, amplitude, and velocity to move joints beyond their passive range of motion but within their physiological limits. The purpose is to restore normal joint motion and function, which can help reduce pain and improve overall health and well-being. It is commonly used to treat musculoskeletal conditions such as low back pain, neck pain, and headaches.
I couldn't find a medical definition for "Hospital Shared Services" as it is more related to hospital administration and management. Here's a definition from a healthcare management perspective:
Hospital Shared Services refer to centralized support services that are shared between different departments or hospitals within a healthcare system. These services can include areas such as:
1. Clinical engineering: Management of medical equipment, maintenance, and repair services.
2. Laboratory services: Centralized laboratory testing and analysis.
3. Radiology and imaging services: Consolidation of radiology and imaging services for improved efficiency and quality.
4. Sterile processing services: Centralization of sterilization and decontamination of medical instruments and supplies.
5. Food and nutrition services: Shared kitchen, meal planning, and delivery services.
6. Environmental services: Shared housekeeping, laundry, and waste management services.
7. Biomedical waste management: Handling, treatment, and disposal of hazardous medical waste.
8. Information technology (IT) services: Centralized IT infrastructure, support, and data management.
9. Human resources: Shared HR functions such as recruitment, training, and benefits administration.
10. Financial services: Shared accounting, billing, and revenue cycle management.
The goal of Hospital Shared Services is to improve operational efficiency, reduce costs, enhance quality, and standardize processes across the healthcare system.
Spinal manipulation is a manual therapy technique often used in the practice of chiropractic, osteopathic medicine, and physical therapy. It involves applying controlled force to the spinal joints, usually through quick and precise thrusting movements. The goal of this technique is to improve mobility and range of motion in the spine, reduce pain and muscle tension, and promote overall function of the nervous system. Spinal manipulation may also be used to treat various conditions such as low back pain, neck pain, headaches, and other musculoskeletal disorders. It is important to note that spinal manipulation should only be performed by licensed healthcare professionals with proper training and expertise in this technique.
Medical Definition of Vitamin A:
Vitamin A is a fat-soluble vitamin that is essential for normal vision, immune function, and cell growth. It is also an antioxidant that helps protect the body's cells from damage caused by free radicals. Vitamin A can be found in two main forms: preformed vitamin A, which is found in animal products such as dairy, fish, and meat, particularly liver; and provitamin A carotenoids, which are found in plant-based foods such as fruits, vegetables, and vegetable oils.
The most active form of vitamin A is retinoic acid, which plays a critical role in the development and maintenance of the heart, lungs, kidneys, and other organs. Vitamin A deficiency can lead to night blindness, dry skin, and increased susceptibility to infections. Chronic vitamin A toxicity can cause nausea, dizziness, headaches, coma, and even death.
Research, in the context of medicine, is a systematic and rigorous process of collecting, analyzing, and interpreting information in order to increase our understanding, develop new knowledge, or evaluate current practices and interventions. It can involve various methodologies such as observational studies, experiments, surveys, or literature reviews. The goal of medical research is to advance health care by identifying new treatments, improving diagnostic techniques, and developing prevention strategies. Medical research is typically conducted by teams of researchers including clinicians, scientists, and other healthcare professionals. It is subject to ethical guidelines and regulations to ensure that it is conducted responsibly and with the best interests of patients in mind.
Vitamin D is a fat-soluble secosteroid that is crucial for the regulation of calcium and phosphate levels in the body, which are essential for maintaining healthy bones and teeth. It can be synthesized by the human body when skin is exposed to ultraviolet-B (UVB) rays from sunlight, or it can be obtained through dietary sources such as fatty fish, fortified dairy products, and supplements. There are two major forms of vitamin D: vitamin D2 (ergocalciferol), which is found in some plants and fungi, and vitamin D3 (cholecalciferol), which is produced in the skin or obtained from animal-derived foods. Both forms need to undergo two hydroxylations in the body to become biologically active as calcitriol (1,25-dihydroxyvitamin D3), the hormonally active form of vitamin D. This activated form exerts its effects by binding to the vitamin D receptor (VDR) found in various tissues, including the small intestine, bone, kidney, and immune cells, thereby influencing numerous physiological processes such as calcium homeostasis, bone metabolism, cell growth, and immune function.
Oldenlandia
Oldenlandia balfourii
Oldenlandia pulvinata
Oldenlandia aretioides
Oldenlandia corymbosa
Oldenlandia vasudevanii
Oldenlandia ocellata
Oldenlandia adscensionis
Oldenlandia bicornuta
Oldenlandia umbellata
Spermacoceae
List of plants of Burkina Faso
List of extinct flora of Australia
Wendlandia psychotrioides
List of Rubiaceae genera
List of Rubiaceae of South Africa
Rubiaceae
Cyclotide
Gegenes hottentota
Emi Koussi
Oldenlandiopsis
Scleromitrion diffusum
Hippotion boerhaviae
Deacetylasperulosidic acid
Pterophorus ceraunia
Edrastima
Sphingonaepiopsis pumilio
Henrik Bernard Oldenland
Houstonia (plant)
Houstonia subviscosa
Oldenlandia - Wikipedia
SCOPe 2.08: Species: African plant (Oldenlandia affinis) [TaxId: 60225]
NameThatPlant.net: Oldenlandia corymbosa
Oldenlandia-herbacea | Plantslive
Oldenlandia - JJ Drinks - Pace Innovations
Oldenlandia corymbosa - The Linnean Collections
Oldenlandia species ?- Mukurthi National park - eFlora of India
Flora of Malawi: Google maps: Oldenlandia corymbosa
Flora of Malawi: Species information: individual images: Oldenlandia goreensis
Oldenlandia - APOTHATOTE: Your 'It Ain't Cute To Be Sick' Headquarters
Flora of Zambia: Species information: Oldenlandia capensis var. capensis
RCSB PDB - 2KCH: Solution structure of micelle-bound kalata B2
Endangered Plants of North Carolina
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Archives for December 2010 | Cancer
Kiribati report, appendix 4, table 4
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v.22 (2006) - SIDA, contributions to botany - Biodiversity Heritage Library
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Noni Juice Improves Serum Lipid Profiles and Other Risk Markers in Cigarette Smokers
Rubiaceae in Chinese Plant Names @ efloras.org
Herbarium Specimen Details - ISB: Atlas of Florida Plants
Results for Meridian Stomach : Herbs : Rootdown.us
The Use of Plant Antimicrobial Compounds for Food Preservation
Affinis1
- Oldenlandia affinis Oldenlandia albonervia (Beddome) Gamble Oldenlandia aretioides Oldenlandia balfourii Oldenlandia bicornuta Oldenlandia cana Bremek. (wikipedia.org)
Rubiaceae1
- Oldenlandia is a genus of flowering plants in the family Rubiaceae. (wikipedia.org)
Diffusa3
- Oldenlandia capensis Oldenlandia cornata Craib Oldenlandia corymbosa L. Oldenlandia diffusa Oldenlandia forcipistipula Verdc. (wikipedia.org)
- Infused with Oldenlandia diffusa, this crisp and refreshing drink helps to quench thirst, eliminate toxins, clear heat and delivers an ultimate cooling sensation. (paceinnovations.net)
- To reveal the effects of Oldenlandia diffusa (OD) on relieving the progression and development of gestational diabetes mellitus (GDM), and explore the underlying mechanism. (qascf.com)
Corymbosa2
- The type species for the genus is Oldenlandia corymbosa. (wikipedia.org)
- Oldenlandia corymbosa L. var. (malawiflora.com)
Genus3
- The genus Oldenlandia, as presently defined, is several times polyphyletic and will eventually be reduced to a group of species closely related to the type species. (wikipedia.org)
- This group, known informally as Oldenlandia sensu stricto, is sister to a section of Kohautia that will eventually be separated from Kohautia and named as a new genus. (wikipedia.org)
- Oldenlandia, or more commonly know as Oldenlandia , is of the genus Oldenlandia. (sagebud.com)
Hedyotis2
- Some botanists have not recognized Oldenlandia, but have placed some or all of its species in a broadly defined Hedyotis. (wikipedia.org)
- More recently, the circumscription of Hedyotis has been narrowed to a monophyletic group of about 115 species and no longer includes Oldenlandia. (wikipedia.org)
Flora1
- Flora of Zambia: Species information: Oldenlandia capensis var. (zambiaflora.com)
Species1
- Oldenlandia was named by Linnaeus in 1753 in Species Plantarum. (wikipedia.org)
Umbellata1
- papuana Oldenlandia thysanota (Halford) Halford Oldenlandia umbellata Oldenlandia uvinsae Verdc. (wikipedia.org)
Capensis2
- Oldenlandia capensis L.f. var. (zambiaflora.com)
- Other sources of information about Oldenlandia capensis var. (zambiaflora.com)
Bremek3
- Oldenlandia adscensionis (extinct: 1889) Oldenlandia aegialoides Bremek. (wikipedia.org)
- Oldenlandia ocellata Oldenlandia oxycoccoides Bremek. (wikipedia.org)
- Oldenlandia patula Bremek. (wikipedia.org)
Extract1
- Carbonated Water, Oldenlandia Extract, Sodium Bicarbonate(E500ii). (paceinnovations.net)
Helps1
- According to the "Compendium of Materia Medica", Oldenlandia Water is a valuable herbal medicine, which helps digestion, detoxification, liver protection, stomach and heat. (tongeeshop.com)
Roxb1
- Oldenlandia herbacea (L.) Roxb. (co.zw)
Pulvinata1
- Oldenlandia pulvinata Oldenlandia sieberi Baker Oldenlandia sieberi var. (wikipedia.org)
Herb1
- Oldenlandia herb cools Heat, strongly resolves Fire and promotes the evacuation of Dampness through the urine. (acu-market.com)