AnatomyOrganismsChemicals and Drugs
OplopanaxPolyacetylenesAraliaceaeDiynesPlant BarkPlant Extracts
Oplopanax
A plant genus in the family ARALIACEAE, order Apiales, subclass Rosidae. It is the source of cirensenosides (triterpenoid saponins).
Polyacetylenes
Hydrocarbons with more than one triple bond; or an oxidized form of POLYENES. They can react with SULFUR to form THIOPHENES.
Araliaceae
The ginseng plant family of the order Apiales, subclass Rosidae, class Magnoliopsida. Leaves are generally alternate, large, and compound. Flowers are five-parted and arranged in compound flat-topped umbels. The fruit is a berry or (rarely) a drupe (a one-seeded fruit). It is well known for plant preparations used as adaptogens (immune support and anti-fatigue).
Diynes
Compounds with two triple bonds. Some of them are CYTOTOXINS.
Plant Bark
The outer layer of the woody parts of plants.
Plant Extracts
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.

Gitksan medicinal plants--cultural choice and efficacy. (1/11)

BACKGROUND: The use of plants for healing by any cultural group is integrally related to local concepts of the nature of disease, the nature of plants, and the world view of the culture. The physical and chemical properties of the plants themselves also bear on their selection by people for medicines, as does the array of plants available for people to choose from. I examine use of medicinal plants from a "biobehavioral" perspective to illuminate cultural selection of plants used for medicine by the Gitksan of northwestern British Columbia, Canada. METHODS: Consultant consensus, "intercultural consensus", independent use of the same plants by other cultural groups, and phytochemistry and bioassay results from the literature, were employed in analysis of probable empirical efficacy of plant uses. RESULTS: 70% of 37 Gitksan medicinal plants were used similarly by other cultures where direct diffusion is not known to have occurred; eleven plants, including the eight most frequently mentioned medicinal plants, also show active phytochemicals or bioassays indicating probable physiologically based therapeutic effects. CONCLUSION: Analysis of intercultural consensus revealed that the majority of cultures in the British Columbia region within the plant ranges use the same plants, or closely related species, in similar ways. The rigor of this analysis is effected by the lack of consistent data on all taxa of interest for all cultures within the region.  (+info)

Counter-current chromatography based analysis of synergy in an anti-tuberculosis ethnobotanical. (2/11)

The crude extract of an Alaskan ethnobotanical plant, Oplopanax horridus, was subjected to counter-current chromatography (CCC), and the selected active regions were evaluated for their synergistic effects with an in vitro model of anti-tubercular efficacy. CCC as a support-free high-resolution separation method was employed to preclude potential irreversible absorption to a solid stationary phase. The microplate Alamar blue assay and the isobole method were used to measure the biological activity and eliminate dose-response dependent errors, respectively. Using the combination of CCC, bioassay and isobole method, significant synergistic effects were observed. Among the entire polarity range, fractions with distribution constant between 0.44 and 0.81 showed the most synergistic enhancement with an increase in potency by 108% for the recombined fractions.  (+info)

High performance liquid chromatographic analysis and anticancer potential of Oplopanax horridus: comparison of stem and berry extracts. (3/11)

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Improving anticancer activities of Oplopanax horridus root bark extract by removing water-soluble components. (4/11)

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Effects of Oplopanax horridus on human colorectal cancer cells. (5/11)

AIM: In this study, we investigated the inhibitive effects of Oplopanax horridus extract (OhE) and its fractions (OhF1, OhF2, OhF3, OhF4 and OhF5) on the growth of human colorectal cancer cells and the possible mechanisms involved were investigated. MATERIALS AND METHODS: The antiproliferative effects were evaluated by MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tet razolium) cell proliferation assay. Apoptotic effects and cell cycle distribution were analyzed by flow cytometry after staining with Annexin V/PI or PI/RNase. RESULTS: After treatment for 48 h, OhE, OhF4 and OhF5 (10-100 microg/ml) inhibited proliferation of HCT-116, SW-480 and HT-29 cell lines, and cell growth decreased most with the treatment of OhF4. On the other hand, OhF1, OhF2 and OhF3 were not observed to have obvious suppressive effects on these cell lines at concentrations of 10-100 microg/ml. OhE, OhF4 and OhF5 (1-10 microg/ml) noticeably induced apoptosis time- and concentration-dependently compared to the control at the same time point. Treatment with OhE, OhF4 or OhF5 (1-10 microg/ml) for 24 h distinctly induced a G(2)/M-phase arrest of the cell cycle in a dose-dependent manner. The trend of increasing cyclin A and cyclin B1 were similar to the increase of G(2)/M phase cells in all treated groups. CONCLUSION: These results showed that OhE had potential antiproliferative effects on human colorectal cancer cells, and the active components are enriched in the OhF4 and OhF5 fractions. The anticancer mechanism of OhE, OhF4 and OhF5 might be attributed to the induction of apoptosis and the regulation of cell cycle transition.  (+info)

Isolation and identification of two new polyynes from a North American ethnic medicinal plant--Oplopanax horridus (Smith) Miq. (6/11)

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Hydrophobic constituents and their potential anticancer activities from Devil's Club (Oplopanax horridus Miq.). (7/11)

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Oplopanphesides A-C, three new phenolic glycosides from the root barks of Oplopanax horridus. (8/11)

Three new phenolic glycosides, named oplopanphesides A-C (1-3), have been isolated from the root barks of Oplopanax horridus. Their structures were elucidated by a combination of spectroscopic analyses, including 1D- and 2D-NMR techniques. These phenolic glycosides possess a novel feature in their sugar moieties that a 3-hydroxy-3-methylglutaryl moiety was connected with C-6 of the beta-D-glucopyranosyl group. Those compounds showed no cytotoxic effects against human cancer cell lines (MDA-231 and MCF-7) by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method.  (+info)

Oplopanax horridus, also known as Devil's Club, is a plant species native to North America, whose root bark contains various pharmacologically active compounds, including anti-inflammatory, analgesic, and hypoglycemic agents, although its therapeutic use requires further scientific investigation and clinical validation.

'Oplopanax' is a botanical term referring to a genus of shrubs in the family Araliaceae, which includes two species native to North America: Oplopanax horridus (also known as Devil's Club) and Oplopanax occidentalis (also known as Western or Alaska Ginseng). These plants have been used in traditional medicine by indigenous peoples for various purposes, such as treating skin conditions, arthritis, and diabetes. However, it is important to note that the scientific evidence supporting these uses is limited, and further research is needed before any definitive medical claims can be made. Additionally, some parts of these plants contain compounds that may have toxic effects if ingested in large quantities or by certain individuals, so they should only be used under the guidance of a knowledgeable healthcare provider.

Polyacetylenes are naturally occurring compounds in some plants, characterized by alternating double and triple bonds in their carbon chain, which may exhibit various bioactivities including anti-inflammatory, antimicrobial, and cytotoxic effects.

Polyacetylenes are a type of chemical compound that naturally occur in certain plants, including members of the families Asteraceae (daisies, sunflowers) and Apiaceae (carrots, parsley). They are characterized by alternating double bonds along their carbon chain, which can give them unique chemical properties. Some polyacetylenes have been found to have potential medicinal benefits, such as anti-inflammatory and anticancer effects. However, they can also be toxic in high concentrations. It's important to note that the term "polyacetylenes" refers to a broad class of compounds, and individual members may have different properties and effects.

Araliaceae is a family of dicotyledonous plants, primarily found in tropical and subtropical regions, characterized by their simple or compound leaves, and small flowers arranged in umbels, which includes economically important genera like Panax (ginseng), and Aralia (common names: Hercules' club, prickly ash).

Araliaceae is a family of flowering plants, also known as the aralia family or ivy family. It includes a wide variety of trees, shrubs, and herbaceous plants, many of which have compound leaves and small clusters of flowers. Some well-known members of this family include the genera Aralia (commonly called "aralias" or "devil's walkingsticks"), Panax (which includes ginseng), Hedera (common ivy), and Schefflera (also known as umbrella trees). The plants in this family are found primarily in tropical and subtropical regions around the world.

'Diynes' are organic compounds characterized by the presence of two carbon-carbon triple bonds in their molecular structure, typically represented by the general formula R-C≡C-C≡C-R', where R and R' are often hydrogen atoms or carbon chains.

Diynes are organic compounds that contain two carbon-carbon triple bonds in their molecular structure. The general chemical formula for diynes is R-C≡C-C≡C-R, where R can be a hydrogen atom or any organic group. Diynes are important building blocks in organic synthesis and have been used to create complex molecules, nanomaterials, and pharmaceuticals. They are also of interest in materials science due to their unique electronic properties and potential applications in optoelectronics and photonics.

'Plant bark' is the outer protective layer of trees and other woody plants, composed of dead cells that provide support, protection from external factors, and contribute to water and nutrient transportation within the plant.

I'm sorry for any confusion, but "Plant Bark" is not a term with a specific medical definition. In general, the bark refers to the outermost covering of a tree or other plant, which serves as protection and provides a barrier against external threats. It is composed of layers including the inner bark (phloem), which transports nutrients throughout the plant, and the outer bark (periderm), which is made up of dead cells that form a protective layer.

While some plants or plant parts do have medicinal properties and are used in various forms of traditional or alternative medicine, "Plant Bark" by itself does not have any specific medical connotations. If you're referring to a specific type of plant bark with potential medicinal uses, please provide more details so I can give a more accurate response.

'Plant extracts' are defined as substances obtained from any plant material, including leaves, flowers, fruits, seeds, stems, roots, bark or wood, through various extraction methods, which may contain a range of bioactive compounds with potential therapeutic benefits, but also variability in composition and quality.

A plant extract is a preparation containing chemical constituents that have been extracted from a plant using a solvent. The resulting extract may contain a single compound or a mixture of several compounds, depending on the extraction process and the specific plant material used. These extracts are often used in various industries including pharmaceuticals, nutraceuticals, cosmetics, and food and beverage, due to their potential therapeutic or beneficial properties. The composition of plant extracts can vary widely, and it is important to ensure their quality, safety, and efficacy before use in any application.

HorridusHorridumElatusAraliaceae2019FatsiaPlantSpeciesGinsengGenus
Horridus12
  • There are three recognized species of Oplopanax in the world: Oplopanax elatus, Oplopanax horridus, Oplopanax japonicus. (wikipedia.org)
  • Photo: Oplopanax horridus 4. (henriettes-herb.com)
  • used luciferin and BLI as a confirmation of several putative anticancer compounds from the North American Oplopanax horridus plant, including falcarindiol and oplopantriol A, which showed potent antiproliferative effects in vitro and in vivo on the HTC-116 tumor strain. (goldbio.com)
  • Identification of potential anticancer compounds from Oplopanax horridus. (goldbio.com)
  • Many hikers in Washington state have encountered - to their dismay - the prickly spines of devil's club, Oplopanax horridus , a shrub which grows in abundance in the Pacific Northwest as well as near Lake Superior. (mountaineers.org)
  • Scientific name: Oplopanax horridus Miq. (brit.org)
  • The Devil's Club (Oplopanax horridus) is a distinctive plant native to the forests of North America, specifically in the Pacific Northwest region, which includes notable areas like Harper Park. (harperspark.ca)
  • They don't call it Oplopanax horridus for nothing. (blogspot.com)
  • High performance liquid chromatographic analysis and anticancer potential of Oplopanax horridus: comparison of stem and berry extracts. (uchicago.edu)
  • Hydrophobic constituents and their potential anticancer activities from Devil's Club (Oplopanax horridus Miq. (uchicago.edu)
  • Improving anticancer activities of Oplopanax horridus root bark extract by removing water-soluble components. (uchicago.edu)
  • Anticancer activities of polyynes from the root bark of Oplopanax horridus and their acetylated derivatives. (uchicago.edu)
Horridum1
Elatus8
  • Isolation and structural elucidation of the triterpenoid saponins of Oplopanax elatus Nakai. (unboundmedicine.com)
  • Compounds 1-4 are new triterpenoid saponins and isolated from the leaves of Oplopanax elatus Nakai for the first time. (unboundmedicine.com)
  • TY - JOUR T1 - Structures of four new triterpenoid saponins from the leaves of Oplopanax elatus Nakai. (unboundmedicine.com)
  • AU - Wang,Guang-shu, AU - Yang,Xiao-hong, AU - Xu,Jing-da, PY - 2004/9/2/pubmed PY - 2004/12/16/medline PY - 2004/9/2/entrez SP - 354 EP - 8 JF - Yao xue xue bao = Acta pharmaceutica Sinica JO - Yao Xue Xue Bao VL - 39 IS - 5 N2 - AIM: Isolation and structural elucidation of the triterpenoid saponins of Oplopanax elatus Nakai. (unboundmedicine.com)
  • Synergetic Inhibition of Human Colorectal Cancer Cells by Combining Polyyne-Enriched Fraction from Oplopanax elatus and Irinotecan. (uchicago.edu)
  • In the process of continuing to investigate ultraviolet b (UVB) irradiation protective constituents from Oplopanax elatus stems, nine new sesquiterpenes, named as eurylosesquiterpenosides A-D (1-4), eurylosesquiterpenols E-I (5-9), and ten known ones (10-19) were gained. (figshare.com)
  • Natural News) Oplopanax elatus, commonly known as nakai, is an herb native to northern China that is known for its anti-cancer effects, especially against colorectal cancer (CRC). (naturalnews.com)
  • Polyyne-Enriched Extract from Oplopanax elatus Significantly Ameliorates the Progression of Colon Carcinogenesis in ApcMin/+ Mice. (uchicago.edu)
Araliaceae1
  • Oplopanax is a small genus of flowering plants in the family Araliaceae, consisting of three species of deciduous shrubs, native to western North America and northeastern Asia. (wikipedia.org)
20191
  • Allium hagen ved Ringve Botaniske Hagen (NTNU) i Trondheim inneholder en samling av gamle norske matløk samlet fra hele Norge i perioden 2008-2019. (edimentals.com)
Fatsia1
  • Oplopanax is closely related to the Asian genus Fatsia. (wikipedia.org)
Plant1
  • En inderdaad in de plant werden alkylamides gedetecteerd, dezelfde stoffen die ook rode zonnehoed zijn werkzaamheid geven. (google.com)
Species1
  • Oplopanax species are closely related to American ginseng. (wikipedia.org)
Ginseng1
  • Oplopanax species are closely related to American ginseng. (wikipedia.org)
Genus1
  • Oplopanax is closely related to the Asian genus Fatsia. (wikipedia.org)

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