'Mouth diseases' is a broad term referring to various conditions that cause inflammation, infection, or structural changes in any part of the mouth, including the lips, gums, tongue, palate, cheeks, and teeth, which can lead to symptoms such as pain, discomfort, difficulty in chewing or speaking, and altered aesthetics.
A loss of mucous substance of the mouth showing local excavation of the surface, resulting from the sloughing of inflammatory necrotic tissue. It is the result of a variety of causes, e.g., denture irritation, aphthous stomatitis (STOMATITIS, APHTHOUS); NOMA; necrotizing gingivitis (GINGIVITIS, NECROTIZING ULCERATIVE); TOOTHBRUSHING; and various irritants. (From Jablonski, Dictionary of Dentistry, 1992, p842)
Epithelial hyperplasia of the oral mucosa associated with Epstein-Barr virus (HERPESVIRUS 4, HUMAN) and found almost exclusively in persons with HIV infection. The lesion consists of a white patch that is often corrugated or hairy.
An acute or chronic GINGIVITIS characterized by redness and swelling, NECROSIS extending from the interdental papillae along the gingival margins, PAIN; HEMORRHAGE, necrotic odor, and often a pseudomembrane. The condition may extend to the ORAL MUCOSA; TONGUE; PALATE; or PHARYNX. The etiology is somewhat unclear, but may involve a complex of FUSOBACTERIUM NUCLEATUM along with spirochetes BORRELIA or TREPONEMA.
Disorders of the mouth attendant upon non-oral disease or injury.
'Gingival diseases' is a general term for conditions affecting the soft tissues surrounding and supporting the teeth, primarily characterized by inflammation, bleeding, redness, or swelling, which can progress to periodontal disease if left untreated.
'Tongue diseases' is a broad term referring to various medical conditions that primarily affect the structure, function, or appearance of the tongue, including but not limited to infections, inflammatory conditions, autoimmune disorders, congenital abnormalities, and malignancies.
Decreased salivary flow.
Tuberculosis of the mouth, tongue, and salivary glands.
'Tooth diseases' is a broad term referring to various conditions affecting the teeth, including dental caries (cavities), periodontal disease (gum disease), tooth wear, tooth sensitivity, oral cancer, and developmental anomalies, which can result in pain, discomfort, or loss of teeth if left untreated.
Lip diseases refer to various medical conditions that primarily affect the lips, causing symptoms such as inflammation, pain, dryness, discoloration, or abnormal growths, which may result from infectious, autoimmune, genetic, traumatic, or neoplastic causes.
General or unspecified diseases of the stomatognathic system, comprising the mouth, teeth, jaws, and pharynx.
An acquired or hereditary condition due to deficiency in the formation of tooth enamel (AMELOGENESIS). It is usually characterized by defective, thin, or malformed DENTAL ENAMEL. Risk factors for enamel hypoplasia include gene mutations, nutritional deficiencies, diseases, and environmental factors.
Stomatitis caused by Herpesvirus hominis. It usually occurs as acute herpetic stomatitis (or gingivostomatitis), an oral manifestation of primary herpes simplex seen primarily in children and adolescents.
Infection of the mucous membranes of the mouth by a fungus of the genus CANDIDA. (Dorland, 27th ed)
Dental care for patients with chronic diseases. These diseases include chronic cardiovascular, endocrinologic, hematologic, immunologic, neoplastic, and renal diseases. The concept does not include dental care for the mentally or physically disabled which is DENTAL CARE FOR DISABLED.
'Gingival neoplasms' are abnormal, uncontrolled growths of tissue originating from the gingiva, which can be benign (non-cancerous) or malignant (cancerous), often manifesting as swellings, ulcerations, or masses within the oral cavity.
Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations.
A recurrent disease of the oral mucosa of unknown etiology. It is characterized by small white ulcerative lesions, single or multiple, round or oval. Two to eight crops of lesions occur per year, lasting for 7 to 14 days and then heal without scarring. (From Jablonski's Dictionary of Dentistry, 1992, p742)
Oral lesions accompanying cutaneous lichen planus or often occurring alone. The buccal mucosa, lips, gingivae, floor of the mouth, and palate are usually affected (in a descending order of frequency). Typically, oral lesions consist of radiating white or gray, velvety, threadlike lines, arranged in a reticular pattern, at the intersection of which there may be minute, white, elevated dots or streaks (Wickham's striae). (Jablonski, Illustrated Dictionary of Dentistry)
Pathological processes involving the PERIODONTIUM including the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, and the PERIODONTAL LIGAMENT.
Group of chronic blistering diseases characterized histologically by ACANTHOLYSIS and blister formation within the EPIDERMIS.

Oral manifestations of Crohn's disease. (1/3)

In a systematic study of 100 patients with Crohn's disease, 100 with ulcerative colitis, and of 100 normal subjects matched for age, sex, and denture status, nine patients with Crohn's disease, two with ulcerative colitis, and one normal control were found to have oral lesions. In Crohn's disease, the macroscopic and histological appearances resembled those encountered elsewhere in the gastrointestinal tract and their incidence was related to the activity of the disorder. The lesions in the other two groups were different macroscopically and histologically. Production of salivary IgA was found to be reduced in Crohn's patients with active bowel disease. It is suggested that the occurrence of oral lesions in patients with Crohn's disease might represent a local immunological reaction to oral antigens.  (+info)

Chronic cutaneous graft-versus-host disease in man. (2/3)

This clinicopathologic study of patients with chronic graft-versus-host disease (GVHD) after allogeneic marrow transplantation emphasizes the most prominent feature of the syndrome, the cutaneous aspects, and describes the ophthalmic-oral sicca syndrome with sialoadenitis and the neurologic findings. Chronic cutaneous GVHD affected 19 of 92 recipients surviving 150 days or more. In 6 patients chronic GVHD presented as a continuation of acute GVHD; in 8 it occurred after the resolution of acute GVHD; and in 5 it arose without preceding acute GVHD, ie, de novo late onset. Two cutaneous types were distinguished. The generalized type affected 16 patients and ran a progressive course resulting in late complications of poikiloderma, diffuse dermal and subcutaneous fibrosis, and contractures. Microscopically, it resembled generalized morphea and lupus erythermatosus hypertrophicus et profundus. The local type affected 3 patients with a more variable picture of poikiloderma, dermal sclerosis, and contractures. Microscopically, it resembled lupus of erythematosus profundus and scleroderma. Guidelines for defining and subclassifying chronic cutaneous GVHD are proposed.  (+info)

Halitosis. (3/3)

Bad breath, halitosis, is an unpleasant problem most people try to avoid. Physicians seem particularly adept at avoiding halitosis by referring patients with this problem to a dentist. However, halitosis may be a symptom of a serious disease. Even if a serious disorder is not present, the cause of bad breath can usually be determined and appropriate therapy given. In this article the causes of halitosis and suggestions for treatment are outlined.  (+info)

Mouth diseases refer to a variety of conditions that affect the oral cavity, including the lips, gums, teeth, tongue, palate, and lining of the mouth. These diseases can be caused by bacteria, viruses, fungi, or other organisms. They can also result from injuries, chronic illnesses, or genetic factors.

Some common examples of mouth diseases include dental caries (cavities), periodontal disease (gum disease), oral herpes, candidiasis (thrush), lichen planus, and oral cancer. Symptoms may include pain, swelling, redness, bleeding, bad breath, difficulty swallowing or speaking, and changes in the appearance of the mouth or teeth. Treatment depends on the specific diagnosis and may involve medications, dental procedures, or lifestyle changes.

An oral ulcer is a defect or break in the continuity of the epithelium, the tissue that lines the inner surface of the mouth, leading to an inflamed, painful, and sometimes bleeding lesion. They can be classified as primary (e.g., aphthous ulcers, traumatic ulcers) or secondary (e.g., those caused by infections, underlying systemic conditions, or reactions to medications). Oral ulcers may cause discomfort, impacting speech and food consumption, and their presence might indicate an underlying medical issue that requires further evaluation.

Hairy leukoplakia is a medical condition characterized by the presence of white, thickened patches or lesions that develop on the tongue or inside of the cheek. It gets its name "hairy" from the appearance of tiny, hair-like projections on the surface of the lesions. This condition is most commonly associated with the Epstein-Barr virus (EBV) and is considered an oral manifestation of HIV/AIDS. However, it can also occur in individuals with a weakened immune system due to other causes. It's important to note that while hairy leukoplakia itself is not cancerous, it can indicate an increased risk for developing oral cancer.

Necrotizing ulcerative gingivitis (NUG), also known as trench mouth or acute necrotizing ulcerative gingivostomatitis, is a severe and painful form of gingivitis that is characterized by the presence of necrosis (tissue death) and ulcers in the gum tissue. It is caused by a combination of factors, including poor oral hygiene, stress, smoking, and a weakened immune system. The condition is often associated with the presence of certain types of bacteria that produce toxins that can damage the gum tissue.

NUG is characterized by the sudden onset of symptoms such as severe pain, bleeding, bad breath, and a grayish-white or yellowish film covering the gums. The gums may also appear bright red, swollen, and shiny, and may bleed easily when brushed or touched. In some cases, the condition can progress to involve other areas of the mouth, such as the lining of the cheeks and lips.

NUG is typically treated with a combination of professional dental cleaning, antibiotics to eliminate the bacterial infection, and pain management. It is important to maintain good oral hygiene practices to prevent recurrence of the condition. If left untreated, NUG can lead to more serious complications such as tooth loss or spread of the infection to other parts of the body.

'Oral manifestations' refer to the visible symptoms or changes that occur in the oral cavity (mouth), which can indicate an underlying medical condition or disease process. These manifestations can include lesions, ulcers, blisters, swelling, discoloration, or abnormal growths on the lips, tongue, gums, palate, or other areas inside the mouth.

Oral manifestations may be caused by a variety of factors, including infections (such as herpes simplex virus or candidiasis), autoimmune diseases (such as lichen planus or pemphigus vulgaris), nutritional deficiencies, or cancerous and precancerous conditions.

It is important to note that oral manifestations may be the first sign of a systemic disease, and therefore, any persistent or unexplained changes in the oral cavity should be evaluated by a healthcare professional or dental provider as soon as possible.

Gingival diseases are infections or inflammations that affect the gingiva, which is the part of the gum around the base of the teeth. These diseases can be caused by bacteria found in dental plaque and can lead to symptoms such as redness, swelling, bleeding, and receding gums. If left untreated, gingival diseases can progress to periodontal disease, a more serious condition that can result in tooth loss. Common types of gingival diseases include gingivitis and periodontitis.

Tongue diseases refer to various medical conditions that affect the structure, function, or appearance of the tongue. These conditions can be categorized into several types, including:

1. Infections: Bacterial, viral, or fungal infections can cause tongue inflammation (glossitis), pain, and ulcers. Common causes include streptococcus, herpes simplex, and candida albicans.
2. Traumatic injuries: These can result from accidental bites, burns, or irritation caused by sharp teeth, dental appliances, or habitual habits like tongue thrusting or chewing.
3. Neoplasms: Both benign and malignant growths can occur on the tongue, such as papillomas, fibromas, and squamous cell carcinoma.
4. Congenital disorders: Some individuals may be born with abnormalities of the tongue, like ankyloglossia (tongue-tie) or macroglossia (enlarged tongue).
5. Neurological conditions: Certain neurological disorders can affect tongue movement and sensation, such as Bell's palsy, stroke, or multiple sclerosis.
6. Systemic diseases: Various systemic conditions can have symptoms that manifest on the tongue, like diabetes mellitus (which can cause dryness and furring), iron deficiency anemia (which may lead to atrophic glossitis), or Sjögren's syndrome (which can result in xerostomia).
7. Idiopathic: In some cases, the cause of tongue symptoms remains unknown, leading to a diagnosis of idiopathic glossitis or burning mouth syndrome.

Proper diagnosis and treatment of tongue diseases require a thorough examination by a healthcare professional, often involving a dental or medical specialist such as an oral pathologist, otolaryngologist, or dermatologist.

Xerostomia is a medical term that describes the subjective feeling of dryness in the mouth due to decreased or absent saliva flow. It's also commonly referred to as "dry mouth." This condition can result from various factors, including medications, dehydration, radiation therapy, Sjögren's syndrome, and other medical disorders. Prolonged xerostomia may lead to oral health issues such as dental caries, oral candidiasis, and difficulty with speaking, chewing, and swallowing.

Tuberculosis (TB), when referring to "oral" or "oropharyngeal," is a specific form of this infectious disease caused by the bacterium Mycobacterium tuberculosis. In oral TB, the infection primarily affects the tissues in and around the mouth and throat (oropharynx). The most common sites for oral TB are the tongue, palate, tonsils, and buccal mucosa (the lining of the inner cheeks).

Oral TB can present with various symptoms, including:

1. Painless or painful ulcers in the mouth or throat
2. Swelling of the lymph nodes in the neck
3. Difficulty swallowing
4. Persistent cough and hoarseness
5. Fever and fatigue
6. Unintentional weight loss

It is important to note that oral TB is relatively rare compared to pulmonary tuberculosis (TB affecting the lungs). However, it can still be transmitted through respiratory droplets or direct contact with infected sputum or saliva. Diagnosis typically involves a combination of clinical examination, imaging studies, and laboratory tests such as smear microscopy, culture, or molecular techniques like PCR to detect the presence of M. tuberculosis in samples taken from the affected area. Treatment usually consists of a standard anti-TB drug regimen recommended by the World Health Organization (WHO) for at least six months.

Tooth diseases are conditions that affect the teeth and can cause discomfort, pain, and even loss of teeth if left untreated. These diseases can be caused by various factors such as poor oral hygiene, bacterial infections, trauma, genetics, and certain medical conditions. Some common tooth diseases include:

1. Dental caries (tooth decay): This is a breakdown of the tooth enamel due to the action of acid-producing bacteria that feed on sugars and starches in the mouth. Over time, this can lead to cavities or holes in the teeth.
2. Gingivitis: This is an inflammation of the gums caused by the buildup of plaque and tartar at the gum line. If left untreated, gingivitis can progress to periodontitis, a more serious form of gum disease that can cause tooth loss.
3. Periodontitis: This is a severe infection of the gums and bones that support the teeth. It is caused by the buildup of plaque and tartar, which leads to the destruction of the tissue and bone that hold the teeth in place.
4. Abscess: This is a pocket of pus that forms in the tooth or gum due to a bacterial infection. An abscess can cause pain, swelling, and fever, and may require antibiotics or surgical drainage.
5. Tooth erosion: This is the loss of tooth structure due to acid wear, which can be caused by factors such as diet, stomach acid, and teeth grinding.
6. Hypersensitivity: This is a condition in which the teeth become sensitive to hot, cold, or sweet foods and drinks. It can be caused by factors such as gum recession, tooth decay, and tooth wear.
7. Oral cancer: This is a type of cancer that affects the mouth, lips, tongue, or throat. It can cause symptoms such as sores, lumps, or difficulty swallowing, and may require surgery, radiation therapy, or chemotherapy for treatment.

Lip diseases refer to various medical conditions that affect the lips, which can be caused by different factors such as infections, inflammation, allergies, or autoimmune disorders. Some examples of lip diseases include:

1. Cheilitis: It is an inflammation of the lips, which can cause dryness, cracking, and soreness. It can be caused by various factors, including irritants, allergies, or infections.
2. Angular cheilitis: It is a condition that causes inflammation and redness at the corners of the mouth. It can be caused by fungal or bacterial infections, ill-fitting dentures, or vitamin deficiencies.
3. Herpes simplex labialis: Also known as cold sores, it is a viral infection that causes painful blisters on the lips and around the mouth. The virus can be spread through close contact with an infected person.
4. Actinic cheilitis: It is a precancerous condition caused by excessive exposure to the sun, which leads to dry, scaly, or thickened patches on the lips.
5. Fordyce spots: These are small, painless, white or yellowish bumps that appear on the lips and inside the mouth. They are harmless and do not require treatment.
6. Lip cancer: It is a type of skin cancer that affects the lips, usually caused by excessive exposure to the sun. The symptoms include a sore or lump on the lip that does not heal, bleeding, pain, or numbness.

If you experience any symptoms related to lip diseases, it is recommended to consult a healthcare professional for proper diagnosis and treatment.

Stomatognathic diseases are a group of disorders that affect the stomatognathic system, which includes the teeth, periodontal tissues, temporomandibular joints, muscles of mastication, and associated structures. These diseases can manifest as various symptoms such as pain, difficulty in chewing or swallowing, limited mouth opening, and abnormal jaw movements.

Some examples of stomatognathic diseases include temporomandibular disorders (TMD), oral mucosal diseases, dental caries, periodontal disease, oral cancer, and sleep-related breathing disorders. The diagnosis and management of these conditions often require a multidisciplinary approach involving dentists, oral surgeons, orthodontists, physicians, and other healthcare professionals.

Dental enamel hypoplasia is a condition characterized by the deficiency or reduction in the thickness of the tooth's enamel surface. This results in the enamel being thin, weak, and prone to wear, fractures, and dental cavities. The appearance of teeth with enamel hypoplasia may be yellowish, brownish, or creamy white, and they can have pits, grooves, or bands of varying widths and shapes.

Enamel hypoplasia can occur due to various factors, including genetics, premature birth, low birth weight, malnutrition, infections during childhood (such as measles or chickenpox), trauma, exposure to environmental toxins, and certain medical conditions that affect enamel formation.

The condition is usually diagnosed through a dental examination, where the dentist can observe and assess the appearance and structure of the teeth. Treatment options depend on the severity of the hypoplasia and may include fluoride treatments, sealants, fillings, crowns, or extractions in severe cases. Preventive measures such as maintaining good oral hygiene, a balanced diet, and regular dental check-ups can help reduce the risk of developing enamel hypoplasia.

Herpetic stomatitis is a medical condition characterized by inflammation and sores or lesions in the mouth and mucous membranes caused by the herpes simplex virus (HSV). It is typically caused by HSV-1, which is highly contagious and can be spread through direct contact with an infected person, such as through kissing or sharing utensils.

The symptoms of herpetic stomatitis may include small, painful blisters or ulcers in the mouth, gums, tongue, or roof of the mouth; difficulty swallowing; fever; and swollen lymph nodes. The condition can be painful and make it difficult to eat, drink, or talk.

Herpetic stomatitis is usually self-limiting and will resolve on its own within 1-2 weeks. However, antiviral medications may be prescribed to help reduce the severity and duration of symptoms. It's important to practice good oral hygiene during an outbreak to prevent secondary infections.

It's worth noting that herpes simplex virus can also cause cold sores or fever blisters on the lips and around the mouth, which are similar to the lesions seen in herpetic stomatitis but occur outside of the mouth.

Oral candidiasis is a medical condition characterized by an infection of the oral mucous membranes caused by the Candida fungus species, most commonly Candida albicans. It is also known as thrush or oral thrush. The infection typically appears as white, creamy, or yellowish patches or plaques on the tongue, inner cheeks, roof of the mouth, gums, and sometimes on the tonsils or back of the throat. These lesions can be painful, causing soreness, burning sensations, and difficulty swallowing. Oral candidiasis can affect people of all ages; however, it is more commonly seen in infants, elderly individuals, and those with weakened immune systems due to illness or medication use. Various factors such as poor oral hygiene, dentures, smoking, dry mouth, and certain medical conditions like diabetes or HIV/AIDS can increase the risk of developing oral candidiasis. Treatment usually involves antifungal medications in the form of topical creams, lozenges, or oral solutions, depending on the severity and underlying cause of the infection.

Dental care for chronically ill refers to the oral health management and treatment provided to individuals who have chronic medical conditions. These patients often require specialized dental care due to their increased risk of developing oral health problems as a result of their underlying medical condition or its treatment. The goal of dental care for the chronically ill is to prevent and manage dental diseases, such as tooth decay and gum disease, in order to maintain overall health and quality of life. This may involve close collaboration between dental professionals, physicians, and other healthcare providers to ensure that the patient's oral health needs are being met in a comprehensive and coordinated manner.

Gingival neoplasms refer to abnormal growths or tumors that occur in the gingiva, which are the part of the gums that surround the teeth. These growths can be benign (non-cancerous) or malignant (cancerous). Benign neoplasms include conditions such as fibromas, papillomas, and hemangiomas, while malignant neoplasms are typically squamous cell carcinomas.

Gingival neoplasms can present with a variety of symptoms, including swelling, bleeding, pain, and loose teeth. They may also cause difficulty with chewing, speaking, or swallowing. The exact cause of these neoplasms is not always known, but risk factors include tobacco use, alcohol consumption, poor oral hygiene, and certain viral infections.

Diagnosis of gingival neoplasms typically involves a thorough clinical examination, including a dental exam and biopsy. Treatment options depend on the type and stage of the neoplasm, but may include surgery, radiation therapy, chemotherapy, or a combination of these approaches. Regular dental check-ups and good oral hygiene practices can help to detect gingival neoplasms at an early stage and improve treatment outcomes.

The mouth mucosa refers to the mucous membrane that lines the inside of the mouth, also known as the oral mucosa. It covers the tongue, gums, inner cheeks, palate, and floor of the mouth. This moist tissue is made up of epithelial cells, connective tissue, blood vessels, and nerve endings. Its functions include protecting the underlying tissues from physical trauma, chemical irritation, and microbial infections; aiding in food digestion by producing enzymes; and providing sensory information about taste, temperature, and texture.

Aphthous stomatitis, also known simply as canker sores, is a medical condition that involves the development of small, painful ulcers in the mouth. These ulcers typically appear on the inside of the lips or cheeks, under the tongue, or on the gums. They are usually round or oval with a white or yellow center and a red border.

Aphthous stomatitis is not contagious and is thought to be caused by a variety of factors, including stress, hormonal changes, nutritional deficiencies, and injury to the mouth. The ulcers typically heal on their own within one to two weeks, although larger or more severe sores may take longer to heal.

Treatment for aphthous stomatitis is generally focused on relieving symptoms, as there is no cure for the condition. This may include using over-the-counter mouth rinses or topical gels to numb the area and reduce pain, as well as avoiding spicy, acidic, or hard foods that can irritate the ulcers. In some cases, prescription medications may be necessary to help manage more severe or persistent cases of aphthous stomatitis.

Lichen Planus, Oral is a relatively common inflammatory condition that affects the mucous membranes inside the mouth. It is characterized by the presence of white, lacy patches (called Wickham's striae), papules, or plaques on the oral mucosa, which can be uncomfortable or painful, especially when eating spicy, salty, or acidic foods. The condition can also cause soreness, redness, and ulceration in some cases.

The exact cause of oral lichen planus is not known, but it is believed to be related to an abnormal immune response in which the body's immune system attacks the cells in the oral mucosa. The condition can affect people of any age, but it is most commonly seen in middle-aged adults, and it affects women more often than men.

While there is no cure for oral lichen planus, treatment can help to manage symptoms and prevent complications. Topical corticosteroids are often used to reduce inflammation and relieve pain, while systemic medications may be prescribed in severe cases. It is important to avoid irritants such as tobacco, alcohol, and spicy foods, which can exacerbate symptoms. Regular dental check-ups are also recommended to monitor the condition and prevent any complications.

According to the American Academy of Periodontology, periodontal diseases are chronic inflammatory conditions that affect the tissues surrounding and supporting the teeth. These tissues include the gums, periodontal ligament, and alveolar bone. The primary cause of periodontal disease is bacterial plaque, a sticky film that constantly forms on our teeth.

There are two major stages of periodontal disease:

1. Gingivitis: This is the milder form of periodontal disease, characterized by inflammation of the gums (gingiva) without loss of attachment to the teeth. The gums may appear red, swollen, and bleed easily during brushing or flossing. At this stage, the damage can be reversed with proper dental care and improved oral hygiene.
2. Periodontitis: If left untreated, gingivitis can progress to periodontitis, a more severe form of periodontal disease. In periodontitis, the inflammation extends beyond the gums and affects the deeper periodontal tissues, leading to loss of bone support around the teeth. Pockets filled with infection-causing bacteria form between the teeth and gums, causing further damage and potential tooth loss if not treated promptly.

Risk factors for developing periodontal disease include poor oral hygiene, smoking or using smokeless tobacco, genetic predisposition, diabetes, hormonal changes (such as pregnancy or menopause), certain medications, and systemic diseases like AIDS or cancer. Regular dental check-ups and good oral hygiene practices are crucial for preventing periodontal disease and maintaining overall oral health.

Pemphigus is a group of rare, autoimmune blistering diseases that affect the skin and mucous membranes. In these conditions, the immune system mistakenly produces antibodies against desmoglein proteins, which are crucial for maintaining cell-to-cell adhesion in the epidermis (outermost layer of the skin). This results in the loss of keratinocyte cohesion and formation of flaccid blisters filled with serous fluid.

There are several types of pemphigus, including:

1. Pemphigus vulgaris - The most common form, primarily affecting middle-aged to older adults, with widespread erosions and flaccid blisters on the skin and mucous membranes (e.g., mouth, nose, genitals).
2. Pemphigus foliaceus - A more superficial form, mainly involving the skin, causing crusted erosions and scaly lesions without mucosal involvement. It is more prevalent in older individuals and in certain geographical regions like the Middle East.
3. Paraneoplastic pemphigus - A rare type associated with underlying neoplasms (cancers), such as lymphomas or carcinomas, characterized by severe widespread blistering of both skin and mucous membranes, along with antibodies against additional antigens besides desmogleins.
4. IgA pemphigus - A less common form characterized by localized or generalized erosions and blisters, with IgA autoantibodies targeting the basement membrane zone.

Treatment for pemphigus typically involves high-dose systemic corticosteroids, often in combination with immunosuppressive agents (e.g., azathioprine, mycophenolate mofetil, rituximab) to control the disease activity and prevent complications. Regular follow-ups with dermatologists and oral specialists are essential for monitoring treatment response and managing potential side effects.

No FAQ available that match "oral manifestations"

No images available that match "oral manifestations"