Osteoarthritis knee. Medical search. Definitions

Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)

A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.

A synovial hinge connection formed between the bones of the FEMUR; TIBIA; and PATELLA.

Noninflammatory degenerative disease of the hip joint which usually appears in late middle or old age. It is characterized by growth or maturational disturbances in the femoral neck and head, as well as acetabular dysplasia. A dominant symptom is pain on weight-bearing or motion.

A region of the lower extremity immediately surrounding and including the KNEE JOINT.

Replacement of the knee joint.

Injuries to the knee or the knee joint.

Replacement for a knee joint.

A protective layer of firm, flexible cartilage over the articulating ends of bones. It provides a smooth surface for joint movement, protecting the ends of long bones from wear at points of contact.

The interarticular fibrocartilages of the superior surface of the tibia.

Pain in the joint.

A degenerative joint disease involving the SPINE. It is characterized by progressive deterioration of the spinal articular cartilage (CARTILAGE, ARTICULAR), usually with hardening of the subchondral bone and outgrowth of bone spurs (OSTEOPHYTE).

The distance and direction to which a bone joint can be extended. Range of motion is a function of the condition of the joints, muscles, and connective tissues involved. Joint flexibility can be improved through appropriate MUSCLE STRETCHING EXERCISES.

Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.

An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Bony outgrowth usually found around joints and often seen in conditions such as ARTHRITIS.

The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally.

The articulations extending from the WRIST distally to the FINGERS. These include the WRIST JOINT; CARPAL JOINTS; METACARPOPHALANGEAL JOINT; and FINGER JOINT.

A strong ligament of the knee that originates from the posteromedial portion of the lateral condyle of the femur, passes anteriorly and inferiorly between the condyles, and attaches to the depression in front of the intercondylar eminence of the tibia.

The flat, triangular bone situated at the anterior part of the KNEE.

The clear, viscous fluid secreted by the SYNOVIAL MEMBRANE. It contains mucin, albumin, fat, and mineral salts and serves to lubricate joints.

The physical state of supporting an applied load. This often refers to the weight-bearing bones or joints that support the body's weight, especially those in the spine, hip, knee, and foot.

Methods of delivering drugs into a joint space.

Polymorphic cells that form cartilage.

The inner membrane of a joint capsule surrounding a freely movable joint. It is loosely attached to the external fibrous capsule and secretes SYNOVIAL FLUID.

Displacement of bones out of line in relation to joints. It may be congenital or traumatic in origin.

The articulation between the head of one phalanx and the base of the one distal to it, in each finger.

The joint that is formed by the articulation of the head of FEMUR and the ACETABULUM of the PELVIS.

Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.

The properties, processes, and behavior of biological systems under the action of mechanical forces.

Lack of stability of a joint or joint prosthesis. Factors involved are intra-articular disease and integrity of extra-articular structures such as joint capsule, ligaments, and muscles.

Endoscopic examination, therapy and surgery of the joint.

Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

In horses, cattle, and other quadrupeds, the joint between the femur and the tibia, corresponding to the human knee.

Manner or style of walking.

A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.

Roentgenography of a joint, usually after injection of either positive or negative contrast medium.

Inflammation of a synovial membrane. It is usually painful, particularly on motion, and is characterized by a fluctuating swelling due to effusion within a synovial sac. (Dorland, 27th ed)

A therapeutic treatment typically involving INTRA-ARTICULAR INJECTIONS of HYALURONIC ACID and related compounds. The procedure is commonly used in the treatment of OSTEOARTHRITIS with the therapeutic goal to restore the viscoelasticity of SYNOVIAL FLUID, decrease pain, improve mobility and restore the natural protective functions of hyaluronan in the joint.

A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA.

Slippage of the FEMUR off the TIBIA.

Replacement of the hip joint.

The quadriceps femoris. A collective name of the four-headed skeletal muscle of the thigh, comprised of the rectus femoris, vastus intermedius, vastus lateralis, and vastus medialis.

The ligament that travels from the medial epicondyle of the FEMUR to the medial margin and medial surface of the TIBIA. The medial meniscus is attached to its deep surface.

Viscoelastic solutions that are injected into JOINTS in order to alleviate symptoms of joint-related disorders such as OSTEOARTHRITIS.

'Joint diseases' is a broad term that refers to medical conditions causing inflammation, degeneration, or functional impairment in any part of a joint, including the cartilage, bone, ligament, tendon, or bursa, thereby affecting movement and potentially causing pain, stiffness, deformity, or reduced range of motion.

Prevalence of generalised osteoarthritis in patients with advanced hip and knee osteoarthritis: the Ulm Osteoarthritis Study. (1/3222)

OBJECTIVES: Different prevalences of generalised osteoarthritis (GOA) in patients with knee and hip OA have been reported. The aim of this investigation was to evaluate radiographic and clinical patterns of disease in a hospital based population of patient subgroups with advanced hip and knee OA and to compare the prevalence of GOA in patients with hip or knee OA, taking potential confounding factors into account. METHODS: 420 patients with hip OA and 389 patients with knee OA scheduled for unilateral total joint replacement in four hospitals underwent radiographic analysis of ipsilateral and contralateral hip or knee joint and both hands in addition to a standardised interview and clinical examination. According to the severity of radiographic changes in the contralateral joints (using Kellgren-Lawrence > or = grade 2 as case definition) participants were classified as having either unilateral or bilateral OA. If radiographic changes of two joint groups of the hands (first carpometacarpal joint and proximal/distal interphalangeal joints defined as two separate joint groups) were present, patients were categorised as having GOA. RESULTS: Patients with hip OA were younger (mean age 60.4 years) and less likely to be female (52.4%) than patients with knee OA (66.3 years and 72.5% respectively). Intensity of pain and functional impairment at hospital admission was similar in both groups, while patients with knee OA had a longer symptom duration (median 10 years) compared with patients with hip OA (5 years). In 41.7% of patients with hip OA and 33.4% of patients with knee OA an underlying pathological condition could be observed in the replaced joint, which allowed a classification as secondary OA. Some 82.1% of patients with hip and 87.4% of patients with knee OA had radiographic changes in their contralateral joints (bilateral disease). The prevalence of GOA increased with age and was higher in female patients. GOA was observed more often in patients with knee OA than in patients with hip OA (34.9% versus 19.3%; OR = 2.24; 95% CI: 1.56, 3.21). Adjustment for the different age and sex distribution in both patient groups, however, takes away most of the difference (OR = 1.32; 95% CI: 0.89, 1.96). CONCLUSION: The crude results confirm previous reports as well as the clinical impression of GOA being more prevalent in patients with advanced knee OA than in patients with advanced hip OA. However, these different patterns might be attributed to a large part to a different distribution of age and sex in these hospital based populations. (+info)

Down regulation by iron of prostaglandin E2 production by human synovial fibroblasts. (2/3222)

OBJECTIVE: To examine the effect of iron on the prostaglandin (PG) E2 production by human synovial fibroblasts in vitro. METHODS: Human synovial fibroblasts were isolated from synovial tissue of rheumatoid arthritis (RA) and osteoarthritis (OA) patients and cultured in medium. Synovial fibroblasts were stimulated by human recombinant interleukin (IL) 1 beta (0.1-10 ng/ml) with or without ferric citrate (Fe-citrate, 0.01-1 mM). The amount of PGE2 in the culture medium was measured by an enzyme linked immunosorbent assay. RESULTS: The production of PGE2 by the synovial fibroblasts was increased by stimulation with IL1 beta at all concentrations tested. Fe-citrate but not sodium citrate (Na-citrate) down regulated the production of PGE2 by the synovial fibroblasts, both with and without stimulation by IL1 beta. Fe-citrate inhibited the spontaneous PGE2 production by the cells in a dose dependent manner, and a maximum inhibition by Fe-citrate was observed at the concentration of 0.1 mM with IL1 beta stimulation. The down regulation by iron was reversed by the co-addition of desferrioxamine (100 micrograms/ml), an iron chelator. CONCLUSION: Iron down regulates the PGE2 production by synovial fibroblasts in vitro. (+info)

Total knee replacement: should it be cemented or hybrid? (3/3222)

OBJECTIVE: To compare the complication rates associated with total knee arthroplasty against the types of fixation (hybrid or cemented), using a single total knee design (the anatomic modular knee [AMK] prosthesis). DESIGN: A prospective, nonrandomized, controlled trial. SETTING: University Hospital in London, Ont., a tertiary care teaching centre. PATIENTS: Two groups made up of 484 knees in 395 patients (89 bilateral). INTERVENTIONS: In 260 knees a hybrid configuration (cemented tibia and noncemented femur) was used (group 1). In 224 knees the femoral and tibial components were cemented (group 2). All patellae were cemented in both groups. MAIN OUTCOME MEASURES: Clinical results were assessed by The Knee Society Clinical Rating Scores at 3 months, 6 months and yearly intervals. Radiographic results were determined by 3-foot standing radiographs and at each follow-up visit standing knee radiographs, lateral and skyline views. Radiographs were analysed for alignment, presence or absence of radiolucent lines or changes in the position of the implant. All reoperations and nonoperative complications were recorded. RESULTS: At an average follow-up of 4.8 years, 8 knees (1.6%) required reoperation. An analysis of the complications leading to reoperation demonstrated no difference between the 2 groups. CONCLUSIONS: There was no difference in outcome whether the femoral component was cemented or not. Medium-term results of the AMK are excellent with a very low reoperation rate. (+info)

Expression of NG2/human melanoma proteoglycan in human adult articular chondrocytes. (4/3222)

OBJECTIVE: NG2 is a transmembrane chondroitin sulfate (CS) rich proteoglycan originally identified in rats. It has recently been shown to be identical to human melanoma proteoglycan (HMPG). In rats NG2 has a limited distribution in adult tissues, being expressed predominantly by neuronal and glial cells whereas during development it is also expressed in developing mesenchyme including cartilage. NG2/HMPG has putative roles in interactions between glial and melanoma cells with extracellular matrix (ECM) molecules. This study was undertaken to assess whether NG2/HMPG was expressed by normal and osteoarthritic human articular chondrocytes. DESIGN: Cryostat sections of human fetal knee joints and normal and osteoarthritic articular cartilage were immunostained with antibodies against rat NG2 (N143.8) and HMPG (M28B5, 9.2.27). Immunoprecipitation and Western blotting was carried out on protein extracts of chondrocytes from normal and osteoarthritic cartilage. Immunofluorescence of NG2 and potential ligands was carried out in vitro on cells from normal and osteoarthritic cartilage. RESULTS: Fetal and both normal and osteoarthritic adult cartilage showed strong immunoreactivity for NG2/HMPG. Western blotting showed a smeared component of molecular weight greater than 400 kDa and a faint band at 250 kDa which became predominant upon digestion with chondroitinase ABC. Immunofluorescence of chondrocytes in vitro showed NG2 to be distributed in a punctate pattern without co-localization of actin or several ECM proteins including fibronectin and type VI collagen. CONCLUSION: NG2/HMPG is expressed by human fetal and adult chondrocytes and in adult articular chondrocytes the core protein is chondroitin sulfated. The function of this molecular in human articular cartilage remains to be defined. (+info)

Where does it hurt? Pain localization in osteoarthritis of the knee. (5/3222)

OBJECTIVE: To identify the most common sites of pain in symptomatic knee osteoarthritis (OA) and to investigate clinical, radiographic and psychosocial associations of pain occurring in different locations. DESIGN: Sixty-eight outpatients with knee OA were interviewed in detail about their knee pain. Location of pain was recorded on a standard drawing of the knee. Validated instruments were used to measure pain severity, function, depression, anxiety, quality of life, fatigue, helplessness, self efficacy. Pain threshold was measured by dolorimetry and a knee examination performed. Radiographs (anterioposterior and lateral) were viewed if available. RESULTS: Most (85.3%) patients reported either 'generalized' (N = 35, 51.5%) or 'medial' (N = 23, 33.8%) knee pain. There were no differences between groups in pain severity, demographic or psychosocial variables, pain threshold or radiographic location or severity. However, function was significantly worse in the 'generalized' group (WOMAC function score 48.9 +/- 20.8 vs 34.2 +/- 22.3; P = 0.01): this remained significant after adjustment for potential confounding factors. The difference in function was most marked for activities involving knee bending. Early morning stiffness was also greater in the generalized group. CONCLUSIONS: Knee pain is not the same in all individuals with knee OA, confirming the heterogeneity of the condition. Location of pain is usually either generalized or medial. Patients with these patterns do not differ in demographic, radiographic or psychosocial variables but important differences in functional ability can be detected, suggesting differences in the underlying causes of pain and disability between the two groups. (+info)

Longitudinal and cross-sectional variability in markers of joint metabolism in patients with knee pain and articular cartilage abnormalities. (6/3222)

OBJECTIVE: To determine the within- and between-patient variability in the concentrations of synovial fluid, serum and urine markers of joint tissue metabolism in a cohort of patients with knee pain and cartilage changes consistent with early-stage knee osteoarthritis. DESIGN: Samples of synovial fluid, serum, and urine were obtained from 52 patients on eight different occasions during 1 year, as part of a clinical trial in patients with cartilage abnormalities and knee pain. In joint fluid, aggrecan fragments were quantified by dye precipitation and enzyme-linked immunosorbent assay (ELISA), and matrix metalloproteinases-1 and -3, and tissue inhibitor of metalloproteinases-1 by sandwich ELISAs. In serum, keratan sulfate was quantified by ELISA. Type I collagen N-telopeptide cross-links in urine were determined by ELISA. RESULTS: The degree of cross-sectional variability in marker concentrations did not vary between the different sampling occasions, and did not differ between the periods of weeks 0 (baseline), 1-4 (treatment) and 13-26 (follow-up). Both between-patient and within-patient coefficients of variation varied for markers in different body fluid compartments, with the lowest variability for serum keratan sulfate, followed by urine type I collagen N-telopeptide crosslinks, and the highest for synovial fluid markers. For synovial fluid, aggrecan fragments showed the least variability, and matrix metalloproteinases the highest. One patient with septic arthritis showed a fivefold peak increase in joint fluid aggrecan fragment concentrations, while the concentration of matrix metalloproteinase-3 increased 100-fold. CONCLUSIONS: Molecular markers of joint tissue metabolism have been suggested as, for example, outcome measures for clinical trials of disease-modifying drugs in osteoarthritis. This report is the first to present data on between- and within-patient variability for such molecular markers in three different body fluid compartments in stable cohort of patients. The availability of such data enables calculations to determine the number of patients needed in prospective studies using these markers as outcome measures. (+info)

Longitudinal analysis of the relationship between serum insulin-like growth factor-I and radiographic knee osteoarthritis. (7/3222)

OBJECTIVE: To examine the relation between serum insulin-like growth factor I (IGF-I) levels and both incident and progressive radiographic knee osteoarthritis (OA) in the Framingham Osteoarthritis Study. DESIGN: Subjects had bilateral weight-bearing, anterior-posterior knee radiographs performed in 1983-1985 and again in 1992-1993. IGF-I levels were measured from blood specimens obtained in 1988-1989 by a competitive binding radio-immunoassay (RIA) after separation with octadecasilyl-silica cartridges of serum IGF-I from binding proteins. Participants without baseline radiographic OA [Kellgren and Lawrence grades (K&L) = 0-1] were classified as having incident disease if they had K&L > or = 2 grades at follow-up. Progressive OA was defined as an increase in K&L score of > or = 1 in knees with baseline OA (K&L > or = 2). All analyses were knee-based and sex-specific. We examined IGF-I tertiles in relation to the risk of incident and progressive radiographic OA separately, adjusting for age, body mass index (BMI), and baseline K&L score, and used generalized estimating equations to adjust for the correlation between fellow knees. RESULTS: Four hundred and forty-one participants had knee radiographs and serum IGF-I levels measured. No associations were found for serum IGF-I levels and incident [women: OR = 0.9 (0.6-1.7), men OR = 1.2 (0.6-2.6)] or progressive [women OR = 0.9 (0.6-1.6), men OR = 0.9 (0.3-3.0)] radiographic knee OA in either sex. Neither did we observe any association between IGF-I and worsening of individual radiographic features of OA (i.e., osteophyte growth and joint space loss). CONCLUSION: In summary, this longitudinal study did not demonstrate any association of serum IGF-I and incident or progressive radiographic knee OA. Further studies are needed to clarify the role of IGF-I in OA. (+info)

1H NMR investigation of changes in the metabolic profile of synovial fluid in bilateral canine osteoarthritis with unilateral joint denervation. (8/3222)

OBJECTIVE: High resolution 1H-nuclear magnetic resonance (NMR) techniques have been used to compare the effects of unilateral knee-joint denervation on the biochemical profiles of synovial fluid in a bilateral canine model of osteoarthritis. METHOD: Paired synovial fluid samples were obtained from seven dogs all of which had previously undergone bilateral anterior cruciate ligament transection, unilateral knee denervation and contralateral sham nerve exposure. All synovial fluid samples were then analyzed using 500 MHz 1H-CPMG spin-echo NMR Spectroscopy to assess differences in endogenous metabolite levels between the paired fluids. RESULTS: The results indicate statistically significant increases in glycerol, hydroxybutyrate, glutamine/glutamate, creatinine/creatine, acetate and N-acetyl-glycoprotein concentrations in synovial fluids from denervated with respect to control knees. Furthermore, significant trends towards elevated lactate, alanine and pyruvate levels in the denervated knee fluids are consistent with our previous findings comparing NMR spectroscopy metabolic profiles of normal and osteoarthritic canine synovial fluids. CONCLUSION: This study lends support to the principle of neurogenic acceleration of OA in that the observed differences in metabolite concentrations found in the denervated knee fluids seem to correlate with metabolic changes resulting from aggravation of the OA process caused by joint denervation. (+info)

Osteoarthritis (OA) of the knee is a degenerative joint disease that affects the articular cartilage and subchondral bone in the knee joint. It is characterized by the breakdown and eventual loss of the smooth, cushioning cartilage that covers the ends of bones and allows for easy movement within joints. As the cartilage wears away, the bones rub against each other, causing pain, stiffness, and limited mobility. Osteoarthritis of the knee can also lead to the formation of bone spurs (osteophytes) and cysts in the joint. This condition is most commonly found in older adults, but it can also occur in younger people as a result of injury or overuse. Risk factors include obesity, family history, previous joint injuries, and repetitive stress on the knee joint. Treatment options typically include pain management, physical therapy, and in some cases, surgery.

Osteoarthritis (OA) is a type of joint disease that is characterized by the breakdown and eventual loss of cartilage - the tissue that cushions the ends of bones where they meet in the joints. This breakdown can cause the bones to rub against each other, causing pain, stiffness, and loss of mobility. OA can occur in any joint, but it most commonly affects the hands, knees, hips, and spine. It is often associated with aging and can be caused or worsened by obesity, injury, or overuse.

The medical definition of osteoarthritis is: "a degenerative, non-inflammatory joint disease characterized by the loss of articular cartilage, bone remodeling, and the formation of osteophytes (bone spurs). It is often associated with pain, stiffness, and decreased range of motion in the affected joint."

The knee joint, also known as the tibiofemoral joint, is the largest and one of the most complex joints in the human body. It is a synovial joint that connects the thighbone (femur) to the shinbone (tibia). The patella (kneecap), which is a sesamoid bone, is located in front of the knee joint and helps in the extension of the leg.

The knee joint is made up of three articulations: the femorotibial joint between the femur and tibia, the femoropatellar joint between the femur and patella, and the tibiofibular joint between the tibia and fibula. These articulations are surrounded by a fibrous capsule that encloses the synovial membrane, which secretes synovial fluid to lubricate the joint.

The knee joint is stabilized by several ligaments, including the medial and lateral collateral ligaments, which provide stability to the sides of the joint, and the anterior and posterior cruciate ligaments, which prevent excessive forward and backward movement of the tibia relative to the femur. The menisci, which are C-shaped fibrocartilaginous structures located between the femoral condyles and tibial plateaus, also help to stabilize the joint by absorbing shock and distributing weight evenly across the articular surfaces.

The knee joint allows for flexion, extension, and a small amount of rotation, making it essential for activities such as walking, running, jumping, and sitting.

Osteoarthritis (OA) of the hip is a degenerative joint disease that affects the articular cartilage and subchondral bone of the hip joint. It is characterized by the progressive loss of cartilage, remodeling of bone, osteophyte formation (bone spurs), cysts, and mild to moderate inflammation. The degenerative process can lead to pain, stiffness, limited range of motion, and crepitus (grating or crackling sound) during movement.

In the hip joint, OA typically affects the femoral head and acetabulum. As the articular cartilage wears away, the underlying bone becomes exposed and can lead to bone-on-bone contact, which is painful. The body responds by attempting to repair the damage through remodeling of the subchondral bone and formation of osteophytes. However, these changes can further limit joint mobility and exacerbate symptoms.

Risk factors for OA of the hip include age, obesity, genetics, previous joint injury or surgery, and repetitive stress on the joint. Treatment options may include pain management (such as NSAIDs, physical therapy, and injections), lifestyle modifications (such as weight loss and exercise), and, in severe cases, surgical intervention (such as hip replacement).

In medical terms, the knee is referred to as the largest and one of the most complex joints in the human body. It is a hinge joint that connects the thigh bone (femur) to the shin bones (tibia and fibula), enabling movements like flexion, extension, and a small amount of rotation. The knee also contains several other components such as menisci, ligaments, tendons, and bursae, which provide stability, cushioning, and protection during movement.

Arthroplasty, replacement, knee is a surgical procedure where the damaged or diseased joint surface of the knee is removed and replaced with an artificial joint or prosthesis. The procedure involves resurfacing the worn-out ends of the femur (thigh bone) and tibia (shin bone) with metal components, and the back of the kneecap with a plastic button. This surgery is usually performed to relieve pain and restore function in patients with severe knee osteoarthritis, rheumatoid arthritis, or traumatic injuries that have damaged the joint beyond repair. The goal of knee replacement surgery is to improve mobility, reduce pain, and enhance the quality of life for the patient.

Knee injuries refer to damages or harm caused to the structures surrounding or within the knee joint, which may include the bones (femur, tibia, and patella), cartilage (meniscus and articular cartilage), ligaments (ACL, PCL, MCL, and LCL), tendons (patellar and quadriceps), muscles, bursae, and other soft tissues. These injuries can result from various causes, such as trauma, overuse, degeneration, or sports-related activities. Symptoms may include pain, swelling, stiffness, instability, reduced range of motion, and difficulty walking or bearing weight on the affected knee. Common knee injuries include fractures, dislocations, meniscal tears, ligament sprains or ruptures, and tendonitis. Proper diagnosis and treatment are crucial to ensure optimal recovery and prevent long-term complications.

A knee prosthesis, also known as a knee replacement or artificial knee joint, is a medical device used to replace the damaged or diseased weight-bearing surfaces of the knee joint. It typically consists of three components: the femoral component (made of metal) that fits over the end of the thighbone (femur), the tibial component (often made of metal and plastic) that fits into the top of the shinbone (tibia), and a patellar component (usually made of plastic) that replaces the damaged surface of the kneecap.

The primary goal of knee prosthesis is to relieve pain, restore function, and improve quality of life for individuals with advanced knee joint damage due to conditions such as osteoarthritis, rheumatoid arthritis, or traumatic injuries. The procedure to implant a knee prosthesis is called knee replacement surgery or total knee arthroplasty (TKA).

Articular cartilage is the smooth, white tissue that covers the ends of bones where they come together to form joints. It provides a cushion between bones and allows for smooth movement by reducing friction. Articular cartilage also absorbs shock and distributes loads evenly across the joint, protecting the bones from damage. It is avascular, meaning it does not have its own blood supply, and relies on the surrounding synovial fluid for nutrients. Over time, articular cartilage can wear down or become damaged due to injury or disease, leading to conditions such as osteoarthritis.

The menisci are crescent-shaped fibrocartilaginous structures located in the knee joint. There are two menisci in each knee: the medial meniscus and the lateral meniscus. The tibial menisci, also known as the medial and lateral menisci, are named according to their location in the knee joint. They lie on the top surface of the tibia (shin bone) and provide shock absorption, stability, and lubrication to the knee joint.

The tibial menisci have a complex shape, with a wider outer portion called the peripheral rim and a narrower inner portion called the central portion or root attachment. The menisci are attached to the bones of the knee joint by ligaments and have a rich blood supply in their outer portions, which helps in healing after injury. However, the inner two-thirds of the menisci have a poor blood supply, making them more prone to degeneration and less likely to heal after injury.

Damage to the tibial menisci can occur due to trauma or degenerative changes, leading to symptoms such as pain, swelling, stiffness, and limited mobility of the knee joint. Treatment for meniscal injuries may include physical therapy, bracing, or surgery, depending on the severity and location of the injury.

Arthralgia is a medical term that refers to pain in the joints. It does not involve inflammation, which would be referred to as arthritis. The pain can range from mild to severe and may occur in one or multiple joints. Arthralgia can have various causes, including injuries, infections, degenerative conditions, or systemic diseases. In some cases, the underlying cause of arthralgia remains unknown. Treatment typically focuses on managing the pain and addressing the underlying condition if it can be identified.

Osteoarthritis of the spine, also known as spondylosis, is a degenerative joint disease that affects the spine. It is characterized by the breakdown and eventual loss of cartilage in the joints of the spine, which can lead to pain, stiffness, and decreased mobility. The condition most commonly affects the joints in the lower back (lumbar) and neck (cervical) regions of the spine.

The symptoms of osteoarthritis of the spine can vary widely, but may include:

* Pain and stiffness in the neck or back, especially after prolonged periods of inactivity or overuse
* Numbness, tingling, or weakness in the arms or legs, due to nerve compression
* Decreased range of motion and flexibility in the spine
* Popping, cracking, or grinding sounds in the spine with movement
* In severe cases, loss of bladder or bowel control.

The diagnosis of osteoarthritis of the spine is typically made through a combination of physical exam, medical history, and imaging studies such as X-rays, MRI, or CT scan. Treatment options may include pain medication, physical therapy, exercise, and in some cases, surgery.

Articular Range of Motion (AROM) is a term used in physiotherapy and orthopedics to describe the amount of movement available in a joint, measured in degrees of a circle. It refers to the range through which synovial joints can actively move without causing pain or injury. AROM is assessed by measuring the degree of motion achieved by active muscle contraction, as opposed to passive range of motion (PROM), where the movement is generated by an external force.

Assessment of AROM is important in evaluating a patient's functional ability and progress, planning treatment interventions, and determining return to normal activities or sports participation. It is also used to identify any restrictions in joint mobility that may be due to injury, disease, or surgery, and to monitor the effectiveness of rehabilitation programs.

Pain measurement, in a medical context, refers to the quantification or evaluation of the intensity and/or unpleasantness of a patient's subjective pain experience. This is typically accomplished through the use of standardized self-report measures such as numerical rating scales (NRS), visual analog scales (VAS), or categorical scales (mild, moderate, severe). In some cases, physiological measures like heart rate, blood pressure, and facial expressions may also be used to supplement self-reported pain ratings. The goal of pain measurement is to help healthcare providers better understand the nature and severity of a patient's pain in order to develop an effective treatment plan.

Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage. It is a complex phenomenon that can result from various stimuli, such as thermal, mechanical, or chemical irritation, and it can be acute or chronic. The perception of pain involves the activation of specialized nerve cells called nociceptors, which transmit signals to the brain via the spinal cord. These signals are then processed in different regions of the brain, leading to the conscious experience of pain. It's important to note that pain is a highly individual and subjective experience, and its perception can vary widely among individuals.

An osteophyte, also known as a bone spur, is a bony projection that forms along the margins of joints, often as a result of degenerative changes in the cartilage and underlying bone. These changes are most commonly seen in conditions such as osteoarthritis, where the protective cartilage that cushions the ends of bones breaks down, leading to inflammation, pain, and reduced mobility.

Osteophytes can develop in any joint in the body, but they are most commonly found in the spine, hips, knees, and hands. They may vary in size from small bumps to large, irregular growths that can restrict joint movement and cause discomfort or pain. In some cases, osteophytes may also compress nearby nerves, leading to symptoms such as numbness, tingling, or weakness in the affected limb.

While osteophytes are often considered a sign of aging or joint degeneration, they can also be caused by other conditions that put excessive stress on the joints, such as injury, infection, or inflammatory arthritis. Treatment for osteophytes typically involves addressing the underlying cause of joint damage, along with pain management strategies such as physical therapy, medication, or in some cases, surgery.

The tibia, also known as the shin bone, is the larger of the two bones in the lower leg and part of the knee joint. It supports most of the body's weight and is a major insertion point for muscles that flex the foot and bend the leg. The tibia articulates with the femur at the knee joint and with the fibula and talus bone at the ankle joint. Injuries to the tibia, such as fractures, are common in sports and other activities that put stress on the lower leg.

A hand joint, also known as an articulation, is the location at which two or more bones connect. Specifically, in the context of the hand, there are several types of joints:

1. **Metacarpophalangeal (MCP) Joints:** These are the joints located between the metacarpal bones of the hand and the proximal phalanges of the fingers. The MCP joints allow for flexion, extension, abduction, adduction, and circumduction movements.
2. **Proximal Interphalangeal (PIP) Joints:** These are the joints located between the proximal and middle phalanges of the fingers. The PIP joints allow for flexion, extension, and a limited amount of abduction and adduction movements.
3. **Distal Interphalangeal (DIP) Joints:** These are the joints located between the middle and distal phalanges of the fingers. The DIP joints mainly allow for flexion and extension movements.
4. **Carpometacarpal (CMC) Joints:** These are the joints located between the carpal bones of the wrist and the metacarpal bones of the hand. The CMC joints, particularly the first CMC joint at the base of the thumb, allow for a wide range of movements, including flexion, extension, abduction, adduction, and opposition (the ability to touch the tip of the thumb to each of the other fingers).

These hand joints are supported by various structures such as ligaments, tendons, muscles, and cartilage, which provide stability, enable movement, and absorb shock during daily activities.

The Anterior Cruciate Ligament (ACL) is a major stabilizing ligament in the knee. It is one of the four strong bands of tissue that connect the bones of the knee joint together. The ACL runs diagonally through the middle of the knee and helps to control the back and forth motion of the knee, as well as provide stability to the knee joint. Injuries to the ACL often occur during sports or physical activities that involve sudden stops, changes in direction, or awkward landings.

The patella, also known as the kneecap, is a sesamoid bone located at the front of the knee joint. It is embedded in the tendon of the quadriceps muscle and serves to protect the knee joint and increase the leverage of the extensor mechanism, allowing for greater extension force of the lower leg. The patella moves within a groove on the femur called the trochlea during flexion and extension of the knee.

Synovial fluid is a viscous, clear, and straw-colored fluid found in the cavities of synovial joints, bursae, and tendon sheaths. It is produced by the synovial membrane, which lines the inner surface of the capsule surrounding these structures.

The primary function of synovial fluid is to reduce friction between articulating surfaces, providing lubrication for smooth and painless movement. It also acts as a shock absorber, protecting the joints from external forces during physical activities. Synovial fluid contains nutrients that nourish the articular cartilage, hyaluronic acid, which provides its viscoelastic properties, and lubricin, a protein responsible for boundary lubrication.

Abnormalities in synovial fluid composition or volume can indicate joint-related disorders, such as osteoarthritis, rheumatoid arthritis, gout, infection, or trauma. Analysis of synovial fluid is often used diagnostically to determine the underlying cause of joint pain, inflammation, or dysfunction.

"Weight-bearing" is a term used in the medical field to describe the ability of a body part or limb to support the weight or pressure exerted upon it, typically while standing, walking, or performing other physical activities. In a clinical setting, healthcare professionals often use the term "weight-bearing exercise" to refer to physical activities that involve supporting one's own body weight, such as walking, jogging, or climbing stairs. These exercises can help improve bone density, muscle strength, and overall physical function, particularly in individuals with conditions affecting the bones, joints, or muscles.

In addition, "weight-bearing" is also used to describe the positioning of a body part during medical imaging studies, such as X-rays or MRIs. For example, a weight-bearing X-ray of the foot or ankle involves taking an image while the patient stands on the affected limb, allowing healthcare providers to assess any alignment or stability issues that may not be apparent in a non-weight-bearing position.

Intra-articular injections refer to the administration of medication directly into a joint space. This route of administration is used for treating various joint conditions such as inflammation, pain, and arthritis. Commonly injected medications include corticosteroids, local anesthetics, and viscosupplementation agents. The procedure is usually performed using imaging guidance, like ultrasound or fluoroscopy, to ensure accurate placement of the medication within the joint.

Chondrocytes are the specialized cells that produce and maintain the extracellular matrix of cartilage tissue. They are responsible for synthesizing and secreting the collagen fibers, proteoglycans, and other components that give cartilage its unique properties, such as elasticity, resiliency, and resistance to compression. Chondrocytes are located within lacunae, or small cavities, in the cartilage matrix, and they receive nutrients and oxygen through diffusion from the surrounding tissue fluid. They are capable of adapting to changes in mechanical stress by modulating the production and organization of the extracellular matrix, which allows cartilage to withstand various loads and maintain its structural integrity. Chondrocytes play a crucial role in the development, maintenance, and repair of cartilaginous tissues throughout the body, including articular cartilage, costal cartilage, and growth plate cartilage.

The synovial membrane, also known as the synovium, is the soft tissue that lines the inner surface of the capsule of a synovial joint, which is a type of joint that allows for smooth movement between bones. This membrane secretes synovial fluid, a viscous substance that lubricates and nourishes the cartilage and helps to reduce friction within the joint during movement.

The synovial membrane has a highly specialized structure, consisting of two layers: the intima and the subintima. The intima is a thin layer of cells that are in direct contact with the synovial fluid, while the subintima is a more fibrous layer that contains blood vessels and nerves.

The main function of the synovial membrane is to produce and regulate the production of synovial fluid, as well as to provide nutrients to the articular cartilage. It also plays a role in the immune response within the joint, helping to protect against infection and inflammation. However, abnormalities in the synovial membrane can lead to conditions such as rheumatoid arthritis, where the membrane becomes inflamed and produces excess synovial fluid, leading to pain, swelling, and joint damage.

Bone malalignment is a term used to describe the abnormal alignment or positioning of bones in relation to each other. This condition can occur as a result of injury, deformity, surgery, or disease processes that affect the bones and joints. Bone malalignment can cause pain, stiffness, limited mobility, and an increased risk of further injury. In some cases, bone malalignment may require treatment such as bracing, physical therapy, or surgery to correct the alignment and improve function.

A finger joint, also known as an articulation, is the point where two bones in a finger connect and allow for movement. The majority of finger joints are classified as hinge joints, permitting flexion and extension movements. These joints consist of several components:

1. Articular cartilage: Smooth tissue that covers the ends of the bones, enabling smooth movement and protecting the bones from friction.
2. Joint capsule: A fibrous sac enclosing the joint, providing stability and producing synovial fluid for lubrication.
3. Synovial membrane: Lines the inner surface of the joint capsule and produces synovial fluid to lubricate the joint.
4. Volar plate (palmar ligament): A strong band of tissue located on the palm side of the joint, preventing excessive extension and maintaining alignment.
5. Collateral ligaments: Two bands of tissue located on each side of the joint, providing lateral stability and limiting radial and ulnar deviation.
6. Flexor tendons: Tendons that attach to the bones on the palmar side of the finger joints, facilitating flexion movements.
7. Extensor tendons: Tendons that attach to the bones on the dorsal side of the finger joints, enabling extension movements.

Finger joints are essential for hand function and enable activities such as grasping, holding, writing, and manipulating objects.

The hip joint, also known as the coxal joint, is a ball-and-socket type synovial joint that connects the femur (thigh bone) to the pelvis. The "ball" is the head of the femur, while the "socket" is the acetabulum, a concave surface on the pelvic bone.

The hip joint is surrounded by a strong fibrous capsule and is reinforced by several ligaments, including the iliofemoral, ischiofemoral, and pubofemoral ligaments. The joint allows for flexion, extension, abduction, adduction, medial and lateral rotation, and circumduction movements, making it one of the most mobile joints in the body.

The hip joint is also supported by various muscles, including the gluteus maximus, gluteus medius, gluteus minimus, iliopsoas, and other hip flexors and extensors. These muscles provide stability and strength to the joint, allowing for weight-bearing activities such as walking, running, and jumping.

A Severity of Illness Index is a measurement tool used in healthcare to assess the severity of a patient's condition and the risk of mortality or other adverse outcomes. These indices typically take into account various physiological and clinical variables, such as vital signs, laboratory values, and co-morbidities, to generate a score that reflects the patient's overall illness severity.

Examples of Severity of Illness Indices include the Acute Physiology and Chronic Health Evaluation (APACHE) system, the Simplified Acute Physiology Score (SAPS), and the Mortality Probability Model (MPM). These indices are often used in critical care settings to guide clinical decision-making, inform prognosis, and compare outcomes across different patient populations.

It is important to note that while these indices can provide valuable information about a patient's condition, they should not be used as the sole basis for clinical decision-making. Rather, they should be considered in conjunction with other factors, such as the patient's overall clinical presentation, treatment preferences, and goals of care.

Biomechanics is the application of mechanical laws to living structures and systems, particularly in the field of medicine and healthcare. A biomechanical phenomenon refers to a observable event or occurrence that involves the interaction of biological tissues or systems with mechanical forces. These phenomena can be studied at various levels, from the molecular and cellular level to the tissue, organ, and whole-body level.

Examples of biomechanical phenomena include:

1. The way that bones and muscles work together to produce movement (known as joint kinematics).
2. The mechanical behavior of biological tissues such as bone, cartilage, tendons, and ligaments under various loads and stresses.
3. The response of cells and tissues to mechanical stimuli, such as the way that bone tissue adapts to changes in loading conditions (known as Wolff's law).
4. The biomechanics of injury and disease processes, such as the mechanisms of joint injury or the development of osteoarthritis.
5. The use of mechanical devices and interventions to treat medical conditions, such as orthopedic implants or assistive devices for mobility impairments.

Understanding biomechanical phenomena is essential for developing effective treatments and prevention strategies for a wide range of medical conditions, from musculoskeletal injuries to neurological disorders.

Joint instability is a condition characterized by the loss of normal joint function and increased risk of joint injury due to impaired integrity of the supporting structures, such as ligaments, muscles, or cartilage. This can result in excessive movement or laxity within the joint, leading to decreased stability and increased susceptibility to dislocations or subluxations. Joint instability may cause pain, swelling, and limited range of motion, and it can significantly impact a person's mobility and quality of life. It is often caused by trauma, degenerative conditions, or congenital abnormalities and may require medical intervention, such as physical therapy, bracing, or surgery, to restore joint stability.

Arthroscopy is a minimally invasive surgical procedure where an orthopedic surgeon uses an arthroscope (a thin tube with a light and camera on the end) to diagnose and treat problems inside a joint. The surgeon makes a small incision, inserts the arthroscope into the joint, and then uses the attached camera to view the inside of the joint on a monitor. They can then insert other small instruments through additional incisions to repair or remove damaged tissue.

Arthroscopy is most commonly used for joints such as the knee, shoulder, hip, ankle, and wrist. It offers several advantages over traditional open surgery, including smaller incisions, less pain and bleeding, faster recovery time, and reduced risk of infection. The procedure can be used to diagnose and treat a wide range of conditions, including torn ligaments or cartilage, inflamed synovial tissue, loose bone or cartilage fragments, and joint damage caused by arthritis.

Treatment outcome is a term used to describe the result or effect of medical treatment on a patient's health status. It can be measured in various ways, such as through symptoms improvement, disease remission, reduced disability, improved quality of life, or survival rates. The treatment outcome helps healthcare providers evaluate the effectiveness of a particular treatment plan and make informed decisions about future care. It is also used in clinical research to compare the efficacy of different treatments and improve patient care.

The term "stifle" is commonly used in veterinary medicine to refer to the joint in the leg of animals, specifically the knee joint in quadrupeds such as dogs and horses. In human anatomy, this joint is called the patellofemoral joint or knee joint. The stifle is a complex joint made up of several bones, including the femur, tibia, and patella (kneecap), as well as various ligaments, tendons, and cartilage that provide stability and support. Injuries or diseases affecting the stifle can cause lameness, pain, and decreased mobility in animals.

Gait is a medical term used to describe the pattern of movement of the limbs during walking or running. It includes the manner or style of walking, including factors such as rhythm, speed, and step length. A person's gait can provide important clues about their physical health and neurological function, and abnormalities in gait may indicate the presence of underlying medical conditions, such as neuromuscular disorders, orthopedic problems, or injuries.

A typical human gait cycle involves two main phases: the stance phase, during which the foot is in contact with the ground, and the swing phase, during which the foot is lifted and moved forward in preparation for the next step. The gait cycle can be further broken down into several sub-phases, including heel strike, foot flat, midstance, heel off, and toe off.

Gait analysis is a specialized field of study that involves observing and measuring a person's gait pattern using various techniques, such as video recordings, force plates, and motion capture systems. This information can be used to diagnose and treat gait abnormalities, improve mobility and function, and prevent injuries.

Rheumatoid arthritis (RA) is a systemic autoimmune disease that primarily affects the joints. It is characterized by persistent inflammation, synovial hyperplasia, and subsequent damage to the articular cartilage and bone. The immune system mistakenly attacks the body's own tissues, specifically targeting the synovial membrane lining the joint capsule. This results in swelling, pain, warmth, and stiffness in affected joints, often most severely in the hands and feet.

RA can also have extra-articular manifestations, affecting other organs such as the lungs, heart, skin, eyes, and blood vessels. The exact cause of RA remains unknown, but it is believed to involve a complex interplay between genetic susceptibility and environmental triggers. Early diagnosis and treatment are crucial in managing rheumatoid arthritis to prevent joint damage, disability, and systemic complications.

Arthrography is a medical imaging technique used to diagnose problems within joints. It involves the injection of a contrast agent, such as a radiopaque dye or air, into the joint space, followed by the use of fluoroscopy or X-ray imaging to visualize the internal structures of the joint. This can help to identify injuries, tears, or other abnormalities in the cartilage, ligaments, tendons, or bones within the joint.

The procedure is typically performed on an outpatient basis and may be used to diagnose conditions such as shoulder dislocations, rotator cuff tears, meniscal tears in the knee, or hip labral injuries. It is a relatively safe and minimally invasive procedure, although there may be some temporary discomfort or swelling at the injection site. Patients are usually advised to avoid strenuous activity for a day or two following the procedure to allow the contrast agent to fully dissipate from the joint.

Synovitis is a medical condition characterized by inflammation of the synovial membrane, which is the soft tissue that lines the inner surface of joint capsules and tendon sheaths. The synovial membrane produces synovial fluid, which lubricates the joint and allows for smooth movement.

Inflammation of the synovial membrane can cause it to thicken, redden, and become painful and swollen. This can lead to stiffness, limited mobility, and discomfort in the affected joint or tendon sheath. Synovitis may occur as a result of injury, overuse, infection, or autoimmune diseases such as rheumatoid arthritis.

If left untreated, synovitis can cause irreversible damage to the joint and surrounding tissues, including cartilage loss and bone erosion. Treatment typically involves a combination of medications, physical therapy, and lifestyle modifications to reduce inflammation and manage pain.

Viscosupplementation is a medical procedure where a thick, gel-like substance called hyaluronic acid is injected into a joint, usually the knee. The goal of this treatment is to supplement or replace the viscous properties of the synovial fluid within the joint that has become thin and less effective due to aging, arthritis, or injury.

Hyaluronic acid is a naturally occurring substance in the body, particularly in the synovial fluid, which acts as a lubricant and shock absorber for the joints. By injecting additional hyaluronic acid into the affected joint, viscosupplementation aims to improve joint mobility, reduce pain, and protect the cartilage from further damage.

This procedure is often considered when other treatments, such as physical therapy, pain medications, or corticosteroid injections, have not provided sufficient relief for patients with osteoarthritis or other joint-related conditions. Viscosupplementation can be a short-term solution to alleviate symptoms and improve the quality of life for those suffering from joint pain and stiffness.

Hyaluronic acid is a glycosaminoglycan, a type of complex carbohydrate, that is naturally found in the human body. It is most abundant in the extracellular matrix of soft connective tissues, including the skin, eyes, and joints. Hyaluronic acid is known for its remarkable capacity to retain water, which helps maintain tissue hydration, lubrication, and elasticity. Its functions include providing structural support, promoting wound healing, and regulating cell growth and differentiation. In the medical field, hyaluronic acid is often used in various forms as a therapeutic agent for conditions like osteoarthritis, dry eye syndrome, and skin rejuvenation.

Knee dislocation is a serious and uncommon orthopedic injury that occurs when the bones that form the knee joint (femur, tibia, and patella) are forced out of their normal position due to extreme trauma or force. This injury often requires immediate medical attention and reduction (repositioning) by a healthcare professional. If left untreated, it can lead to serious complications such as compartment syndrome, nerve damage, and long-term joint instability. It's important to note that knee dislocation is different from a kneecap (patellar) dislocation, which involves the patella sliding out of its groove in the femur.

Hip arthroplasty, also known as hip replacement surgery, is a medical procedure where the damaged or diseased joint surfaces of the hip are removed and replaced with artificial components. These components typically include a metal or ceramic ball that replaces the head of the femur (thigh bone), and a polyethylene or ceramic socket that replaces the acetabulum (hip socket) in the pelvis.

The goal of hip arthroplasty is to relieve pain, improve joint mobility, and restore function to the hip joint. This procedure is commonly performed in patients with advanced osteoarthritis, rheumatoid arthritis, hip fractures, or other conditions that cause significant damage to the hip joint.

There are several types of hip replacement surgeries, including traditional total hip arthroplasty, partial (hemi) hip arthroplasty, and resurfacing hip arthroplasty. The choice of procedure depends on various factors, such as the patient's age, activity level, overall health, and the extent of joint damage.

After surgery, patients typically require rehabilitation to regain strength, mobility, and function in the affected hip. With proper care and follow-up, most patients can expect significant pain relief and improved quality of life following hip arthroplasty.

The Quadriceps muscle, also known as the Quadriceps Femoris, is a large muscle group located in the front of the thigh. It consists of four individual muscles - the Rectus Femoris, Vastus Lateralis, Vastus Intermedius, and Vastus Medialis. These muscles work together to extend the leg at the knee joint and flex the thigh at the hip joint. The Quadriceps muscle is crucial for activities such as walking, running, jumping, and kicking.

The medial collateral ligament (MCL) of the knee is a band-like structure located on the inner side of the knee joint. It connects the end of the femur (thighbone) to the top of the tibia (shinbone) and helps stabilize the knee by controlling side-to-side movement and preventing excessive separation of the bones. The MCL provides resistance to valgus force, which is a pushing or pulling force that attempts to push the bones apart in a direction away from the midline of the body. MCL injuries often occur due to direct impact to the outer knee or sudden changes in direction that strain the ligament.

Viscosupplements are a type of medication that contain a gel-like substance called hyaluronic acid, which is naturally found in the synovial fluid of joints. This fluid acts as a lubricant and shock absorber for the joints, allowing smooth movement and protecting them from wear and tear.

In osteoarthritis, the synovial fluid may become less viscous and contain lower levels of hyaluronic acid, leading to pain, stiffness, and reduced mobility in the affected joint. Viscosupplementation involves injecting a preparation of high molecular weight hyaluronic acid into the joint space to restore its normal viscoelastic properties and provide symptomatic relief from osteoarthritis.

Viscosupplements are typically administered through a series of injections, usually given once a week for 3-5 weeks, depending on the specific product used. They may help reduce pain, improve joint function, and increase mobility in people with osteoarthritis, particularly in the knee joint. However, their effectiveness varies from person to person, and they are not recommended for everyone with osteoarthritis. It is important to consult a healthcare provider to determine if viscosupplementation is appropriate for an individual's specific condition.

Joint diseases is a broad term that refers to various conditions affecting the joints, including but not limited to:

1. Osteoarthritis (OA): A degenerative joint disease characterized by the breakdown of cartilage and underlying bone, leading to pain, stiffness, and potential loss of function.
2. Rheumatoid Arthritis (RA): An autoimmune disorder causing inflammation in the synovial membrane lining the joints, resulting in swelling, pain, and joint damage if left untreated.
3. Infectious Arthritis: Joint inflammation caused by bacterial, viral, or fungal infections that spread through the bloodstream or directly enter the joint space.
4. Gout: A type of arthritis resulting from the buildup of uric acid crystals in the joints, typically affecting the big toe and characterized by sudden attacks of severe pain, redness, and swelling.
5. Psoriatic Arthritis (PsA): An inflammatory joint disease associated with psoriasis, causing symptoms such as pain, stiffness, and swelling in the joints and surrounding tissues.
6. Juvenile Idiopathic Arthritis (JIA): A group of chronic arthritis conditions affecting children, characterized by joint inflammation, pain, and stiffness.
7. Ankylosing Spondylitis: A form of arthritis primarily affecting the spine, causing inflammation, pain, and potential fusion of spinal vertebrae.
8. Bursitis: Inflammation of the fluid-filled sacs (bursae) that cushion joints, leading to pain and swelling.
9. Tendinitis: Inflammation or degeneration of tendons, which connect muscles to bones, often resulting in pain and stiffness near joints.

These conditions can impact the function and mobility of affected joints, causing discomfort and limiting daily activities. Proper diagnosis and treatment are essential for managing joint diseases and preserving joint health.

Knee osteoarthritis was the most prevalent type of osteoarthritis, followed by hand osteoarthritis. In 2019, osteoarthritis was ... Severe osteoarthritis and osteopenia of the carpal joint and 1st carpometacarpal joint MRI of osteoarthritis in the knee, with ... Lateral wedge insoles and neutral insoles do not appear to be useful in osteoarthritis of the knee. Knee braces may help but ... April 2018). "Exercise interventions and patient beliefs for people with hip, knee or hip and knee osteoarthritis: a mixed ...

https://en.wikipedia.org/wiki/Osteoarthritis

These may include: Osteoarthritis knee pain usually occurs while the joint is bearing weight, so the pain typically subsides ... Knee effusion, informally known as water on the knee, occurs when excess synovial fluid accumulates in or around the knee joint ... Puffiness around the bony parts of the knee appear prominent when compared with the other knee.[citation needed] When the knee ... If the knee is swollen and red and warm to the touch when compared to the other knee, a doctor may be concerned about ...

https://en.wikipedia.org/wiki/Knee_effusion

Cao P, Li Y, Tang Y, Ding C, Hunter DJ (May 2020). "Pharmacotherapy for knee osteoarthritis: current and emerging therapies". ... Clinical trial number NCT00110916 for "Treatment for Patients With Osteoarthritis (OA) of the Knee" at ClinicalTrials.gov ... Madry H, Luyten FP, Facchini A (March 2012). "Biological aspects of early osteoarthritis". Knee Surgery, Sports Traumatology, ... Hunter DJ (March 2015). "Viscosupplementation for osteoarthritis of the knee". The New England Journal of Medicine. 372 (11): ...

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Katoh, Shojiro (2021). "Enhanced expression of hyaluronic acid in osteoarthritis-affected knee-cartilage chondrocytes during ... "The interaction between weight and family history of total knee replacement with knee cartilage: a 10-year prospective study". ... "All-arthroscopic AMIC procedure for repair of cartilage defects of the knee". Knee Surgery, Sports Traumatology, Arthroscopy. ... Osteoarthritis is a common condition of cartilage failure that can lead to limited range of motion, bone damage and invariably ...

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... (Civanex) is a medication used to treat osteoarthritis of the knee and other neuropathic pain. It is applied three ... This includes herpes simplex infections; cluster headaches and migraine; and knee osteoarthritis. It was approved by the Health ... March 2012). "Civamide cream 0.075% in patients with osteoarthritis of the knee: a 12-week randomized controlled clinical trial ... Other adverse effects observed in clinical trials are eye irritation, arthralgia, aggravated osteoarthritis, burning sensation ...

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"Knee Osteoarthritis: Clinical Update". ResearchGate. Retrieved 2019-07-15. "Book on "Knee Osteoarthritis" released during BIOS ... "Book on "Knee Osteoarthritis" by Indian surgeons released at BIOS conference". biospectrumindia.com. Retrieved 2019-07-15. " ... Vaishya R, Vaish A. Knee Osteoarthritis. Publisher: Kontexworx, New Delhi, India. Vaishya R, Maini L, Haleem A. An update on ... Sharma, Om Prakash (2019-04-01). "Knee Osteoarthritis: Clinical Update". Apollo Medicine. 16 (2): 132. doi:10.4103/am.am_29_19 ...

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Regular wear can cause lower back, hip, and knee issues, which can lead to osteoarthritis. Osteoarthritis occurs when the ... Kerrigan, D. Casey; Lelas, Jennifer L.; Karvosky, Mark E. (2001). "Women's shoes and knee osteoarthritis". The Lancet. 357 ( ...

https://en.wikipedia.org/wiki/KuToo_movement

For the grading of osteoarthritis in the knee, the International Knee Documentation Committee (IKDC) system is regarded to have ... Kim, Young-Mo; Joo, Yong-Bum (2012). "Patellofemoral Osteoarthritis". Knee Surgery & Related Research. 24 (4): 193-200. doi: ... Hefti F, Müller W, Jakob RP, Stäubli HU (1993). "Evaluation of knee ligament injuries with the IKDC form". Knee Surg Sports ... Radiographic systems to classify osteoarthritis vary by which joint is being investigated. In osteoarthritis, the choice of ...

https://en.wikipedia.org/wiki/Radiographic_classification_of_osteoarthritis

Intra-articular injections of hyaluronic acid are used to mitigate pain and treat symptoms of osteoarthritis in the knee, but ... "Viscosupplementation for Osteoarthritis of the Knee". Annals of Internal Medicine. 157 (3): 180-91. doi:10.7326/0003-4819-157-3 ...

https://en.wikipedia.org/wiki/Heparinoid

... in South Africans aged 65 years and older Knee osteoarthritis has the highest prevalence from all types of osteoarthritis, with ... Osteoarthritis usually occurs with age and affects the fingers, knees, and hips. Rheumatoid arthritis is an autoimmune disorder ... "Knee braces for osteoarthritis - Mayo Clinic". www.mayoclinic.org. Retrieved 2021-03-31. Ettinger WH, Burns R, Messier SP, ... Arthroscopic surgery for osteoarthritis of the knee provides no additional benefit to optimized physical and medical therapy. ...

https://en.wikipedia.org/wiki/Arthritis

... osteoarthritis of the knee". This clearance was for over the counter use. Use of pulsed electromagnetic field therapy has been ... pulsed subsensory threshold electrical stimulation vs placebo on pain and physical function in people with knee osteoarthritis ... systematic review with meta-analysis". Osteoarthritis and Cartilage. 21 (9): 1281-1289. doi:10.1016/j.joca.2013.06.015. PMID ...

https://en.wikipedia.org/wiki/Pulsed_electromagnetic_field_therapy

EULAR (2003). "an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing ... 2006). "Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis". N Engl J Med. 354 (8): ... This was a 24-month, double-blind, placebo-controlled study, enrolling 662 people with knee osteoarthritis who satisfied ... treatment of osteoarthritis of the knee, 2nd edition". The Journal of Bone and Joint Surgery. American Volume. 95 (20): 1885-86 ...

https://en.wikipedia.org/wiki/Chondroitin_sulfate

Later in life, he had knee osteoarthritis. He participated in an educational video from The Arthritis Research Centre of Canada ... ARC), demonstrating the physical examination of a patient with knee osteoarthritis. In November 2010, Nielsen was admitted to ...

https://en.wikipedia.org/wiki/Leslie_Nielsen

"Overview , Arthroscopic knee washout, with or without debridement, for the treatment of osteoarthritis , Guidance , NICE". ... treatment of osteoarthritis of the knee, 2nd edition". The Journal of Bone and Joint Surgery. American Volume. 95 (20): 1885-6 ... "Treatment of osteoarthritis of the knee (nonarthroplasty)". The Journal of the American Academy of Orthopaedic Surgeons. 17 (9 ... Reichenbach, S; Rutjes, AW; Nüesch, E; Trelle, S; Jüni, P (12 May 2010). "Joint lavage for osteoarthritis of the knee" (PDF). ...

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Cartilage damage and osteoarthritis in the knee. Haas played for the Swiss national team at Euro 2004 and was sent off in the ...

https://en.wikipedia.org/wiki/Bernt_Haas

She also had osteoarthritis of the knee. On 20 January 2005, Babi died of multiple organ failure. Parveen Babi was born on 4 ...

https://en.wikipedia.org/wiki/Parveen_Babi

Leopold SS (April 2009). "Minimally invasive total knee arthroplasty for osteoarthritis". N. Engl. J. Med. 360 (17): 1749-58. ... Knee replacement involves exposure of the front of the knee, with detachment of part of the quadriceps muscle (vastus medialis ... mostly with knee and hip replacements. About 773,000 Americans had a hip or knee replaced in 2009. For shoulder replacement, ... "Retention versus sacrifice of the posterior cruciate ligament in total knee arthroplasty for treating osteoarthritis". The ...

https://en.wikipedia.org/wiki/Joint_replacement

... as a potential disease modifying agent for the treatment of osteoarthritis of the knee". Osteoarthritis and Cartilage. 26 (1): ... "Cryopreserved Amniotic Suspension for the Treatment of Knee Osteoarthritis". The Journal of Knee Surgery. 29 (6): 443-450. doi: ... for the treatment of knee osteoarthritis". Osteoarthritis and Cartilage. Abstracts from the 2018 OARSI World Congress on ... a novel intra-articular CLK2/DYRK1A inhibitor and Wnt pathway modulator for knee osteoarthritis". Osteoarthritis and Cartilage ...

https://en.wikipedia.org/wiki/Disease-modifying_osteoarthritis_drug

Similarly, European algorithm ESCEO for the treatment of knee osteoarthritis recommends limiting the use of paracetamol to ... "An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and ... "Paracetamol versus placebo for knee and hip osteoarthritis". Cochrane Database Syst Rev. 2 (8): CD013273. doi:10.1002/14651858. ... Conaghan PG, Arden N, Avouac B, Migliore A, Rizzoli R (April 2019). "Safety of Paracetamol in Osteoarthritis: What Does the ...

https://en.wikipedia.org/wiki/Paracetamol

However, loose knee and finger joints can occur. Signs of osteoarthritis usually begin in early adulthood. Children with ... Their x-rays show small and irregular ossification centers, most apparent in the hips and knees. There are very small capital ... Lateral knee radiography can show multi-layered patellae. Multiple epiphyseal dysplasia (MED) encompasses a spectrum of ... Knees have metaphyseal widening and irregularity while hands have brachydactyly (short fingers) and proximal metacarpal ...

https://en.wikipedia.org/wiki/Multiple_epiphyseal_dysplasia

... and Knee Osteoarthritis". International Journal of Athletic Therapy & Training. doi:10.1123/ijatt.2009-0044. ISSN 2157-7277. " ...

https://en.wikipedia.org/wiki/2021_Shepherd_Rams_football_team

... knee osteoarthritis, migraine prophylaxis, and tension-type headache. The trials are considered to be one of the largest ... "Acupuncture and knee osteoarthritis: a three-armed randomized trial". Annals of Internal Medicine. 145 (1): 12-20. doi:10.7326/ ... knee osteoarthritis, migraine prophylaxis, and tension-type headache. Apart from that, an observational study on adverse events ... Joint Committee ruled in April 2006 that the costs of acupuncture treatment for chronic back pain and knee osteoarthritis would ...

https://en.wikipedia.org/wiki/German_acupuncture_trials

Review Date 11/27/2016 Arroll B, Goodyear-Smith F (April 2004). "Corticosteroid injections for osteoarthritis of the knee: meta ... Jevsevar D, Donnelly P, Brown GA, Cummins DS (December 2015). "Viscosupplementation for Osteoarthritis of the Knee: A ... "Viscosupplementation for osteoarthritis of the knee: a systematic review and meta-analysis". Annals of Internal Medicine. 157 ( ... Pain originating from different anatomical areas such as lumbar spine, knee and pelvis can also be referred to the hip and ...

https://en.wikipedia.org/wiki/Ultrasound-guided_hip_joint_injection

Sukenik S; Flusser, D; Codish, S; Abu-Shakra, M (1999). "Balneotherapy at the Dead Sea area for knee osteoarthritis". IMAJ. 1 ( ...

https://en.wikipedia.org/wiki/Balneotherapy

... validity and reliability of the Oxford Knee Score in measuring health outcomes in patients with knee osteoarthritis". ... "An open label study to assess the effectiveness of oral methotrexate in reducing pain in knee osteoarthritis". EU Clinical ... It has been used in clinical studies investigating knee osteoarthritis, urinary incontinence and children who have been ... Arthroplasty (Knee replacement).The Oxford knee score (OKS) is owned by Isis Outcomes and was developed at Oxford University. ...

https://en.wikipedia.org/wiki/List_of_patient-reported_quality_of_life_surveys

"Dead Sea bath salts for osteoarthritis of the knee". Harefuah. 129 (3-4): 100-103, 159, 103. PMID 8543232. "DEA: Chemicals Used ...

https://en.wikipedia.org/wiki/Bath_salts

Steadman JR, Ramappa AJ, Maxwell RB, Briggs KK (2007). "An arthroscopic treatment regimen for osteoarthritis of the knee". ... The knee microfracture surgery technique relies on the release of these cells into a cartilage lesion to initiate ... They reported a case study in which a full-thickness defect in the articular cartilage of a human knee was successfully ... Centeno CJ, Busse D, Kisiday J, Keohan C, Freeman M, Karli D (2008). "Increased knee cartilage volume in degenerative joint ...

https://en.wikipedia.org/wiki/Stem_cell_transplantation_for_articular_cartilage_repair

Raposo, Filipe; Ramos, Marta; Lúcia Cruz, Ana (December 2021). "Effects of exercise on knee osteoarthritis: A systematic review ... Osteoarthritis is caused by normal wear-and-tear of the joints and worsened by extreme forces or injury, whereas autoimmune ... "Osteoarthritis vs. Rheumatoid Arthritis". UCF Health. Retrieved 2023-04-17. Hsu, Joseph R.; Mir, Hassan; Wally, Meghan K.; ... For mild pain (i.e. minor trauma, tendinopathies, osteoarthritis) there are many conservative or at-home treatments available ...

https://en.wikipedia.org/wiki/Elbow_pain

Elite-level long-distance running is associated with a three to seven times higher risk of the knee osteoarthritis later in ... "Is Participation in Certain Sports Associated With Knee Osteoarthritis? A Systematic Review". Journal of Athletic Training. 52 ...

https://en.wikipedia.org/wiki/Long-distance_running

... half a cannabis brownie in the morning and another half in the afternoon to ease the pain of osteoarthritis in her knees. She ... Rathbun suffered from chronic obstructive pulmonary disease and osteoarthritis. She survived colon cancer and walked with ... artificial knees. Rathbun often self-medicated by consuming ...

https://en.wikipedia.org/wiki/Brownie_Mary

... than a year experience improvement in pain and physical function when they initiate exercise therapy for knee osteoarthritis. ... DENVER - Initiating exercise therapy early on in people who develop symptoms of knee osteoarthritis - even within their first ... Although the benefits of exercise therapy for advanced knee osteoarthritis had already been well established, this study looked ... Cite this: Early Exercise Intervention Improves Knee Osteoarthritis - Medscape - Mar 21, 2023. ...

https://www.medscape.com/viewarticle/989951

A device that delivers electric current to the knees could help combat osteoarthritis, a painful condition caused by worn ... Electric knee implants could help treat pain of osteoarthritis. A device that delivers electric current to the knees could help ... Osteoarthritis is a common cause of knee pain as people get older. It involves the wear and tear of cartilage, a rubbery layer ... Read more: Cartilage from the nose used to treat two peoples knee osteoarthritis. ...

https://www.newscientist.com/article/2304357-electric-knee-implants-could-help-treat-pain-of-osteoarthritis/

... s a new treatment option for knee pain sufferers who don't want to go under the knife for a replacement. ... New Knee Device Helping Patients With Intermediate Osteoarthritis. February 15, 2019 / 6:10 PM. / CBS Pittsburgh ... A normal knee looks like a smooth, white cueball, but Stenger had osteoarthritis, a wear-and-tear kind of arthritis, where it ... "It says if you are having pain on the medial side of your knee, and youve been diagnosed with osteoarthritis, fill out the ...

https://www.cbsnews.com/pittsburgh/news/new-knee-device-intermediate-osteoarthritis/

Autologous conditioned serum (Orthokine) is an effective treatment for knee osteoarthritis. Osteoarthritis Cartilage2009;17:152 ... OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthritis Cartilage2019; ... Intra-articular sodium hyaluronate in osteoarthritis of the knee: a multicenter, double-blind study. Osteoarthritis Cartilage ... Single intra-articular injection of lightly cross-linked hyaluronic acid reduces knee pain in symptomatic knee osteoarthritis: ...

https://www.bmj.com/content/378/bmj-2022-069722

Arthroscopic surgery for osteoarthritis of the knee provides no additional benefit to optimized physical and medical therapy. ( ... A randomized trial of arthroscopic surgery for osteoarthritis of the knee N Engl J Med. 2008 Sep 11;359(11):1097-107. doi: ... Background: The efficacy of arthroscopic surgery for the treatment of osteoarthritis of the knee is unknown. ... Conclusions: Arthroscopic surgery for osteoarthritis of the knee provides no additional benefit to optimized physical and ...

https://pubmed.ncbi.nlm.nih.gov/18784099/?dopt=Abstract

Increased vitamin D levels appear to improve muscle strength and physical function for vitamin D-deficient patients with knee ... While previous studies have associated vitamin D deficiencies with an increased risk for severity of knee osteoarthritis, the ... physical function for vitamin D-deficient patients with knee osteoarthritis, according to research presented this week. ... and 550,000 have moderate to severe osteoarthritis in their knees.. Incidence is rising in ageing populations and those with ...

https://www.nutraingredients-usa.com/Article/2004/10/21/Vitamin-D-improves-symptoms-of-knee-osteoarthritis

Adolescent anterior knee pain has traditionally been described as running a benign and self-limiting course. Studies more ... Is anterior knee pain a predisposing factor to patellofemoral osteoarthritis? Knee. 2005 Oct;12(5):362-5. doi: 10.1016/j.knee. ... DOI: 10.1016/j.knee.2004.12.006 Abstract Adolescent anterior knee pain has traditionally been described as running a benign and ... raising the question as to whether anterior knee pain may be one of the contributing factors to patellofemoral osteoarthritis ...

https://pubmed.ncbi.nlm.nih.gov/16146626/?dopt=Abstract

It can cause pain and stiffness in one or both of your knees. Learn more here. ... Knee osteoarthritis is one of the most common types of osteoarthritis. ... About knee osteoarthritis. If you have knee osteoarthritis, the different structures that make up your knee joint will have ... Symptoms of knee osteoarthritis. Knee osteoarthritis usually affects both of your knees and symptoms include the following. ...

https://www.bupa.co.uk/health-information/knee-pain/knee-osteoarthritis

... function and other symptoms of knee osteoarthritis - making Tai Chi a viable treatment alternative for people suffering with ... Tai Chi found to be as effective as physical therapy for knee osteoarthritis. Date:. November 7, 2015. Source:. American ... Both Tai Chi and physical therapy positively impact pain, function and other symptoms of knee osteoarthritis - making Tai Chi a ... Both Tai Chi and physical therapy positively impact pain, function and other symptoms of knee osteoarthritis -- making Tai Chi ...

https://www.sciencedaily.com/releases/2015/11/151107172939.htm

Osteoarthritis is common in the knees because the knees bear the weight of the body. Osteoarthritis of the knee can severely ... Osteoarthritis, also called degenerative arthritis, is a gradual breakdown of cartilage in the joints. Cartilage is a tough, ...

https://www.scoi.com/patient-resources/education/osteoarthritis-knee

... knee osteoarthritis (OA) poses a significant challenge to both patients and healthcare providers but while painkillers remain a ... knee osteoarthritis (OA) poses a significant challenge to both patients and healthcare providers... read full story ... Prevalence of knee pain rose 65pc in 20 years, seminar told. The News International. 2023-11-19, 00:06 ...

https://article.wn.com/view/2023/11/20/6_holistic_approaches_to_manage_knee_Osteoarthritis_beyond_p/

... reply about the EULAR recommendations for the management of knee osteoarthritis (OA).1 ,2 ... by M Dougados and M Doherty it seems to me that treatment of knee OA with symptomatic slow acting drugs in osteoarthritis ( ...

https://ard.bmj.com/content/60/10/984.1

New research suggests that chronic knee pain caused by osteoarthritis does not cause cognitive impairment in isolation, ... Study: Chronic knee pain caused by osteoarthritis does not cause cognitive impairment in isolation. *Download PDF Copy ... In the experimental model, they found no evidence for osteoarthritis-like knee pain to cause impairments in memory and ... This suggests that chronic pain caused by knee osteoarthritis may impact cognitive functions less than other chronic pain ...

https://www.news-medical.net/news/20230627/Study-Chronic-knee-pain-caused-by-osteoarthritis-does-not-cause-cognitive-impairment-in-isolation.aspx

i,Objective,/i,. This meta-analysis aims to assess the efficacy of acupuncture-related therapy on knee osteoarthritis (KOA) ... Y. B. Fu, J. W. Chen, B. Li, F. Yuan, and J. Q. Sun, "[Effect of fire needling on mild to moderate knee osteoarthritis and ... J. N. Katz, K. R. Arant, and R. F. Loeser, "Diagnosis and treatment of hip and knee osteoarthritis," JAMA, vol. 325, no. 6, pp ... J. Li, Y.-X. Li, L.-J. Luo et al., "The effectiveness and safety of acupuncture for knee osteoarthritis," Medicine, vol. 98, no ...

https://www.hindawi.com/journals/ecam/2022/2831332/

Strong Thigh Muscles Protect Women From Knee Osteoarthritis Reported August 31, 2009 (Ivanhoe Newswire) -- Women with the ... Of those enrolled, a total of 2,519 knees were included in the study of radiographic knee OA and 3,392 knees were evaluated for ... in the Multicenter Knee Osteoarthritis Study (MOST) to assess whether knee extensor strength would predict OA that can be ... The knee is the weight-bearing joint most commonly affected by osteoarthritis. The Centers for Disease Control and Prevention ( ...

https://www.womenfitness.net/news-flash/strong_thigh_muscles_protect_women_from_knee_osteoarthritis-2/?amp=1

Exercise is recommended as a core treatment for osteoarthritis in all clinical guidelines regardless of patient age, pain ... Exercise for knee osteoarthritis Intervention. Regular land- or water-based therapeutic exercise for adults with knee ... Home Clinical resources Clinical guidelines Handbook of Non-Drug Interventions (HANDI) Exercise for knee osteoarthritis ... Exercise for knee osteoarthritis - a 6-month free research-based exercise and education program including printable exercises ...

https://www.racgp.org.au/clinical-resources/clinical-guidelines/handi/handi-interventions/exercise/exercise-for-knee-osteoarthritis

A knee brace for osteoarthritis is also known as an OA knee brace (OA is short for ... What is an Osteoarthritis Knee Brace?. A knee brace for osteoarthritis is also known as an OA knee brace (OA is short for " ... OA Knee Bracing. Knee braces specifically designed for osteoarthritis are a viable treatment option for many people. ... How Does an Osteoarthritis Knee Brace Work?. There are two types of unloading brace designs, push and pull. The push design, ...

https://www.breg.com/osteoarthritis/knee-bracing/

Finite Element Analysis (FEA) was performed for an extended knee position of the knee joint. Contact pressure distributions on ... This implant is designed to eliminate excessive loads through the knee and to provide suitable conditions for possible ... The implant was designed for the medial side of the knee joint. ... study the efficacy of a novel implant for osteoarthritic knees ... Biomechanics of a novel extra-articular implant for younger patients with knee osteoarthritis. * Mehdi Saeidi , Maziar Ramezani ...

https://www.degruyter.com/document/doi/10.1515/cdbme-2018-0050/html

Randomised controlled trial of magnetic bracelets for relieving pain in osteoarthritis of the hip and knee BMJ 2004; 329 :1450 ... Randomised controlled trial of magnetic bracelets for relieving pain in osteoarthritis of the hip and knee. BMJ 2004; 329 doi: ... Patients who wore standard magnetic bracelets reported reduced pain from osteoarthritis of the hip or knee compared with ... Randomised controlled trial of magnetic bracelets for relieving pain in osteoarthritis of the hip and knee ...

https://www.bmj.com/content/329/7480/1450/related

... to identify signaling pathways and crucial proteins involved in the pathological mechanism of KBD compared with osteoarthritis ... OA). The knee cartilage samples were collected from gender- and age-matched KBD (n = 9) and OA (n = 9) patients. After pre- ... OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthritis and Cartilage 22, 363-388 (2014). ... Comparative analysis of gene expression profiles between primary knee osteoarthritis and an osteoarthritis endemic to ...

https://www.nature.com/articles/s41598-020-63932-6?error=cookies_not_supported&code=66bca41d-a26d-4cb0-afca-0af120ed490e

... has one of the nations largest and most respected research programs for people who suffer the pain of knee osteoarthritis, ... For people who suffer the pain and disability of knee osteoarthritis (OA), Tufts Medical Center not only has one of the ... "Osteoarthritis is a common disorder that currently has no disease-modifying treatments," says Timothy McAlindon, MD, Chief of ... Another NIH-funded study to determine if vitamin D taken once a day helps to slow the progression of knee OA is just wrapping ...

https://www.tuftsmedicalcenter.org/News-Events-Media/News/Good-Medicine/2010/Bringing-knee-osteoarthritis-research-into-clinical-practice

Knee osteoarthritis (OA) is a complex disease with several proposed mechanisms for both the initiation and progression of the ... Browsing University of Waterloo by Subject "Knee Osteoarthritis". 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q. R. S ... An Evaluation of Knee Joint Laxity, Mechanics and Muscle Activation Following Sustained Deep Flexion Kneeling Mines, Daniel ( ...

https://uwspace.uwaterloo.ca/handle/10012/1/browse?type=subject&value=Knee+Osteoarthritis

Knee osteoarthritis accounts for 97% of all knee replacement surgeries. Trials of bisphosphonates in knee osteoarthritis have ... Articles tagged with "knee osteoarthritis". Beyond Drugs: ACR/AF Guideline Update for Hand, Knee & Hip OA Emphasizes Exercise. ... NEW YORK (Reuters Health)-The rate of knee replacement surgery among older women with knee osteoarthritis is lower in those who ... A two-year study among patients with knee osteoarthritis (OA) showed that steroid injections for knee pain were no more ...

https://www.the-rheumatologist.org/tag/knee-osteoarthritis/

1) 44 patents with advanced osteoarthritis of the knee who were awaiting total knee joint replacements were given acupuncture ... 1) 44 patents with advanced osteoarthritis of the knee who were awaiting total knee joint replacements were given acupuncture ... traditionally indicated for knee pain, with a simulated acupuncture treatment (control group) in postoperative knee pain ... 2) 60 patients on a waiting list for total knee replacement were randomly divided into two groups. 30 received medical ...

https://www.avicenna.co.uk/research-lifestyle/acupuncture-and-knee-osteoarthritis-208/

Physical therapy interventions for knee pain secondary to osteoarthritis: a systematic review. Ann Intern Med 2012 Nov 6;157(9 ... Internet Citation: Systematic Review: Physical Therapy Interventions for Knee Pain Secondary to Osteoarthritis. Content last ... Physical Therapy Interventions for Knee Pain Secondary to Osteoarthritis. Oct 6, 2010 ... and harms with physical therapy interventions in community-dwelling adults with chronic knee pain secondary to osteoarthritis ...

https://effectivehealthcare.ahrq.gov/products/arthritis-knee-physical-therapy/research

Hip and Knee Osteoarthritis. People presenting with persistent joint pain over the age 45 years are often given the diagnosis ... Hip and Knee Osteoarthritis File type: application/pdf Review date: June 2022 ... of Osteoarthritis (OA). Osteoarthritis presents as normal age related changes in joints. OA is not simply a process of the wear ...

https://www.esht.nhs.uk/leaflet/hip-and-knee-osteoarthritis/

View Knee Osteoarthritis PPTs online, safely and virus-free! Many are downloadable. Learn new and interesting things. Get ideas ... JKOM:Japan Knee Osteoarthritis Measure) - JKOM Japan Knee Osteoarthritis Measure * I. ... JKOM Japan Knee Osteoarthritis ... Knee Arthroplasty - Knee Arthroplasty Degeneration of Knee Degeneration of Knee (cont d) Osteoarthritis is the most common ... Niraj Vora, Knee osteoarthritis specialist in Mumbai. Looking for a Knee braces for osteoarthritis in Mumbai, Book an ...

https://www.powershow.com/search/presentations/ppt/knee_osteoarthritis

Only a minority of US Medicare beneficiaries with knee osteoarthritis in 2005-2010 used non-surgical care such as physical ... therapy and knee injections, and few were treated by rheumatologists, physiatrists, or pain specialists, new research reveals. ... Treat Knee Osteoarthritis This Way, Global Experts Agree. Growth Factor Shows Promise as Knee Osteoarthritis Treatment. ... Surgery May Often Be Substituted for Conservative Knee Osteoarthritis Care. Jun 15, 2021 , Orthopedic , 0 , ...

https://rehabpub.com/conditions/orthopedic/surgery-may-often-be-substituted-for-conservative-knee-osteoarthritis-care/

Proprioception, Knee osteoarthritis, Measurement, Pain, Activity, limitations, Intervention. host publication. Osteoarthritis ... Objective: To give an overview of the literature on knee proprioception in knee osteoarthritis (OA) patients. Method: A ... Objective: To give an overview of the literature on knee proprioception in knee osteoarthritis (OA) patients. Method: A ... Proprioception in knee osteoarthritis: a narrative review. *Mark. Knoop, J. ; Steultjens, M. P. M. ; van der Leeden, M. ; van ...

https://lup.lub.lu.se/search/publication/0d857d30-1a67-4a08-aac8-f4cd46a4342a

... no difference in baseline scores or TRR was found between the index knee and contralateral knee (n.s.). An inflammatory ... The TRR of the index knee was 64% at 3 months and 45% at 12 months after injection. Therapy responders at 12 months improved ... Sixty-four subjects with symptomatic mild-severe knee OA were enrolled in a single-center trial and received a unilateral (n = ... administration of MFAT might become a relevant alternative in well-selected patients with symptomatic knee OA. ...

https://www.mdpi.com/2077-0383/10/11/2231

The secondary outcome was the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) function scale. (hindawi.com)
The definition of the Patient Acceptable Symptom State that accounts for patient satisfaction was available for the Western Ontario McMaster Universities Osteoarthritis Index, the Visual Analog Scale for Pain, and the Patient Global Assessment Scale. (ahrq.gov)
Data on assessment of pain and patient's global assessment of disease, measured on visual analogue scales, and functional impairment, measured on the Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) function subscale, were collected at baseline and final visits. (bmj.com)

Knee implants that generate a tiny electrical current may be able to stimulate cartilage regrowth as a treatment for arthritis. (newscientist.com)
Some research suggests that a mild electric current can encourage cartilage cells in the knee to multiply and repair damage . (newscientist.com)
Nguyen's group tested the current idea by creating holes in the knee cartilage of rabbits and patching them up with the material. (newscientist.com)
Osteoarthritis, sometimes called degenerative joint disease, is a slowly progressive disease in which joint cartilage breaks down. (sciencedaily.com)
Osteoarthritis, also called degenerative arthritis, is a gradual breakdown of cartilage in the joints. (scoi.com)
This implant is designed to eliminate excessive loads through the knee and to provide suitable conditions for possible tibiofemoral cartilage regeneration. (degruyter.com)
The knee cartilage samples were collected from gender- and age-matched KBD (n = 9) and OA (n = 9) patients. (nature.com)
We're using dGEMRIC - delayed gadolinium-enhanced MRI of cartilage - to measure regional changes in bone density around the knee joint," McAlindon explains. (tuftsmedicalcenter.org)
Another NIH-funded study to determine if vitamin D taken once a day helps to slow the progression of knee OA is just wrapping up, and an industry-sponsored phase I trial is getting underway to test an injected growth factor called bone morphogenic protein 7 to determine if it will help restore bone or cartilage to knee joints. (tuftsmedicalcenter.org)
A two-year study among patients with knee osteoarthritis (OA) showed that steroid injections for knee pain were no more effective than saline injections and actually reduced cartilage volume more than placebo. (the-rheumatologist.org)
Typically caused by deterioration of knee cartilage, allowing for painful and dangerous bone-to-bone contact, this is a condition that requires proper diagnosis and treatment to provide patient relief. (phc-online.com)
Knee Osteoarthritis is usually caused by deterioration of articular cartilage in older or overweight individuals. (phc-online.com)
Knees are like shock absorbers, and cartilage in the joints can erode over time, but walking improves blood flow and strengthens the muscles and ligaments. (scmp.com)
Osteoarthritis (OA) is a type of degenerative joint disease that results from breakdown of joint cartilage and underlying bone which affects 1 in 7 adults in the United States. (wikipedia.org)
With osteoarthritis, the cartilage breaks down and becomes rough. (medlineplus.gov)
[ 64 ] No single biomarker has proved reliable for diagnosis and monitoring, but combinations of cartilage-derived and bone-derived biomarkers have been used to identify osteoarthritis subtypes, with possible impact on treatment. (medscape.com)
However, the current view holds that osteoarthritis involves not only the articular cartilage but the entire joint organ, including the subchondral bone and synovium. (medscape.com)

A normal knee looks like a smooth, white cueball, but Stenger had osteoarthritis, a wear-and-tear kind of arthritis, where it looks more like potholed asphalt. (cbsnews.com)
More than 7 million adults in the UK - 15 per cent of the population - have long-term health problems due to arthritis and related conditions, according to the Arthritis Research Campaign, and 550,000 have moderate to severe osteoarthritis in their knees. (nutraingredients-usa.com)
This study aimed to assess how many patients who had undergone patellofemoral arthroplasty for isolated patellofemoral arthritis had previously suffered from adolescent anterior knee pain, knee instability and trauma. (nih.gov)
A significant number of patients with patellofemoral arthritis have described preceding anterior knee pain in their adolescence and early adult years, raising the question as to whether anterior knee pain may be one of the contributing factors to patellofemoral osteoarthritis in later years. (nih.gov)
Researchers from the University of Nottingham's School of Life Sciences, School of Psychology, and Pain Centre Versus Arthritis used an experimental model of osteoarthritis-like knee pain to investigate whether such pain alone, without other factors that may often be present in patients with knee osteoarthritis, causes such cognitive impairment. (news-medical.net)
Osteoarthritis (OA) is the most frequent reason for activity limitation in adults and is the most common type of arthritis [ 1 , 2 ]. (hindawi.com)
WEDNESDAY, Nov. 10, 2021 (HealthDay News) - Time spent in recreational physical activity is not associated with an increased risk for incident knee osteoarthritis, according to a study published online Nov. 3 in Arthritis & Rheumatology . (physiciansweekly.com)
Arthritis knee support products such as the osteoarthritis knee supports found here are designed to relieve osteoarthritis pain and protect the knee joint from further damage. (phc-online.com)
To examine the causal associations of diet-derived circulating antioxidants with knee osteoarthritis (OA), hip OA, and rheumatoid arthritis (RA) within the two-sample Mendelian randomization (MR) framework. (frontiersin.org)
As the two most common forms of arthritis, osteoarthritis (OA) and rheumatoid arthritis (RA) affect over 300 million and nearly 20 million people worldwide, respectively. (frontiersin.org)
She is the immediate past chair of the FDA Arthritis Advisory Committee, and serves on the Board of Osteoarthritis Research Society International (OARSI), committees for the American College of Rheumatology (ACR) and International Association for the Study Pain (IASP), and editorial boards, among others. (uwo.ca)
Any other form of arthritis than osteoarthritis. (astrazenecaclinicaltrials.com)
In contrast to rheumatoid arthritis, in osteoarthritis the joints do not become hot or red. (wikipedia.org)
Osteoarthritis is the most common form of arthritis, affecting about 237 million people or 3.3% of the world's population, as of 2015. (wikipedia.org)
[ 1 ] Manifestations of this form of arthritis range from no symptoms to vague anterior knee pain to severe difficulties with stair climbing and ambulation. (medscape.com)

They considered him a good candidate for the study looking at whether a new device, implanted onto the knee joint, will relieve the pain and delay a knee replacement. (cbsnews.com)
Aside from a five-inch scar, you can hardly tell there's a device on the inner side of Stenger's knee joint. (cbsnews.com)
If you have knee osteoarthritis, the different structures that make up your knee joint will have been damaged over time. (bupa.co.uk)
The membranes that line your knee joint can also become inflamed. (bupa.co.uk)
Knee osteoarthritis seems to develop after an injury or a series of minor injuries to your knee joint. (bupa.co.uk)
Use a walking stick to ease any stress on your knee joint. (bupa.co.uk)
The knee is the weight-bearing joint most commonly affected by osteoarthritis. (womenfitness.net)
Study of hip abductor strength, which is important for control of the knee joint, may be useful in a more comprehensive study of risk for OA of the knee," Dr. Segal is quoted as saying. (womenfitness.net)
These braces are supports worn on the knees to provide joint stability and help to correct joint alignment problems. (breg.com)
The implant was designed for the medial side of the knee joint. (degruyter.com)
Finite Element Analysis (FEA) was performed for an extended knee position of the knee joint. (degruyter.com)
Osteoarthritis (OA) is a progressive, degenerative joint disease. (nature.com)
The first is testing the structural effect of intra-articular corticosteroids injected into the knee joint. (tuftsmedicalcenter.org)
Observational studies provided evidence of the association between changes in knee joint functional tests and patient-centered outcomes and minimum clinically important differences in validated tools for outcome measures. (ahrq.gov)
People presenting with persistent joint pain over the age 45 years are often given the diagnosis of Osteoarthritis (OA). (esht.nhs.uk)
Anterior cruciate ligament integrity in osteoarthritis of the knee in patients undergoing total knee replacement - Dr. Sunil Rajan is a orthopaedic surgeon, joint replacement and Knee specialist in Indore, Madhya Pradesh. (powershow.com)
Dr. Sunil Rajan is a orthopaedic surgeon, joint replacement and Knee specialist in Indore, Madhya Pradesh. (powershow.com)
Osteoarthritis (OA) is a degenerative joint disorder typically involving the knees, hips, and hand joints and affects approximately 240 million people worldwide. (medscape.com)
Before and after treatment, the Visual Analogue Scale (VAS), Lysholm knee joint scale and the affected knee joint flexion angle were observed in the two groups. (unboundmedicine.com)
It relieves pain and improves the motion range of knee joint effectively. (unboundmedicine.com)
Although almost all joints could be affected, OA of the knee and hip, two commonly involved joints, contribute the most to the disease burden mainly due to joint replacement ( 3 ). (frontiersin.org)
OA of the knee and hip along with RA are significantly associated with joint function loss, disability, reduced quality of life, and substantial healthcare expenditure, thereby constituting major public health challenges ( 3 , 4 ). (frontiersin.org)
In addition, although an increasing number of anti-rheumatic disease-modifying drugs (DMARDs) are provided for RA, there is no curative drugs available presently ( 4 ), while the management of knee and hip OA is limited to symptom alleviation and total joint replacement for end stage patients ( 3 ). (frontiersin.org)
Osteoarthritis (OA) is the most common degenerative joint disease-causing pain and functional impairment. (novapublishers.com)
Knee Osteoarthritis (KOA), is the most common joint disease worldwide. (iasp-pain.org)
Article: Biomechanics performance in 30-s chair stand test in patients with medial knee osteoarthritis Journal: International Journal of Human Factors and Ergonomics (IJHFE) 2019 Vol.6 No.4 pp.319 - 330 Abstract: Knee osteoarthritis (OA) is characterised by weakness and knee joint pain which may affect the performance in some activities of daily life like sit-to-stand. (inderscience.com)
0.05) between the first three and the last three repetitions in the 30s-CST for knee joint moment and power. (inderscience.com)
Knee osteoarthritis (OA) is characterised by weakness and knee joint pain which may affect the performance in some activities of daily life like sit-to-stand. (inderscience.com)
Physiotherapist Edward Robinson of Joint Dynamics says you're more likely to get knee issues if you are inactive. (scmp.com)
I was shocked to find out that I had severe osteoarthritis in that joint. (oil-testimonials.com)
The doctor will not need to operate on my knee joint. (oil-testimonials.com)
Knee joint instability is frequently reported by patients with knee osteoarthritis (KOA). (eur.nl)
Objective metrics to assess knee joint instability are lacking, making it difficult to target therapies aiming to improve stability. (eur.nl)
Therefore, the aim of this study was to compare responses in neuromechanics to perturbations during gait in patients with self-reported knee joint instability (KOA-I) versus patients reporting stable knees (KOA-S) and healthy control subjects. (eur.nl)
Knee joint angles and muscle activation patterns were compared using statistical parametric mapping and discrete gait parameters. (eur.nl)
These alterations in neuromechanics could assist in the assessment of knee joint instability in patients, to provide treatment options accordingly. (eur.nl)
Furthermore, longitudinal studies are needed to investigate the consequences of altered neuromechanics due to knee joint instability on the development of KOA. (eur.nl)
Six domains gained agreement as mandatory to be measured and reported in all hip and/or knee OA clinical trials: pain, physical function, quality of life, and patient's global assessment of the target joint, in addition to the mandated core domain of adverse events including mortality. (whiterose.ac.uk)
By short-term, we mean usually joint injections that don't necessarily work for more than a few months or invasive treatments, such as knee replacement, which require hospitalization and a prolonged recovery," he added. (medscape.com)
The most commonly involved joints are the two near the ends of the fingers and the joint at the base of the thumbs, the knee and hip joints, and the joints of the neck and lower back. (wikipedia.org)
Osteoarthritis is believed to be caused by mechanical stress on the joint and low grade inflammatory processes. (wikipedia.org)
Osteoarthritis can cause a crackling noise (called "crepitus") when the affected joint is moved, especially shoulder and knee joint. (wikipedia.org)
Osteoarthritis commonly affects the hands, feet, spine, and the large weight-bearing joints, such as the hips and knees, although in theory, any joint in the body can be affected. (wikipedia.org)
Osteoarthritis is the most common cause of a joint effusion of the knee. (wikipedia.org)
The development of osteoarthritis is correlated with a history of previous joint injury and with obesity, especially with respect to knees. (wikipedia.org)
For instance, obesity has been shown to be a predictor of osteoarthritis (MMWR, 2010), suggesting a transference of benefits from obesity prevention to the prevention of joint pain. (cdc.gov)
Symptoms include knee stiffness in the morning and pain that occurs when you apply pressure to the knee joint. (lu.se)
[ 4 , 7 ] One important characteristic of primary osteoarthritis is that the abnormalities found in the load-bearing (ie, highly stressed) areas of the affected joint differ from those found in the non-load-bearing areas. (medscape.com)
The presence of noninflammatory joint fluid helps distinguish osteoarthritis from other causes of joint pain. (medscape.com)
Osteoarthritis (see the image below) is the most common type of joint disease, affecting more than 20 million individuals in the United States alone. (medscape.com)

Chris Yun Lane, PT, DPT, a physical therapist and a fourth-year PhD student at the University of North Carolina at Chapel Hill, was not surprised at the exercise benefit given the extensive evidence already showing that exercise is beneficial for patients with osteoarthritis whose symptoms have lasted longer. (medscape.com)
Ron Ellis Jr., DO, MBA, chief strategy officer of Pacira BioSciences in Tampa, Fla., noted that a lot of patients with knee osteoarthritis have weakness in their quads, so quad strengthening is "a typical part of our improvement program for patients with osteoarthritis," he said in an interview. (medscape.com)
The purpose of this study is to evaluate the safety and tolerability of a single intravenous dose of MEDI-578, a monoclonal antibody, in patients with osteoarthritis of the knee. (astrazenecaclinicaltrials.com)
Levels of acute-phase reactants are typically within the reference range in patients with osteoarthritis. (medscape.com)
Magnetic resonance imaging (MRI) can depict many of the same characteristics of osteoarthritis that plain radiography can, but it is not necessary in most patients with osteoarthritis, unless additional pathology amenable to surgical repair is suspected. (medscape.com)

Current Guidelines for Osteoarthritis: What Are the Practice Implications for Oral NSAIDs? (medscape.com)
OBJECTIVES: To determine whether there is a difference in the relative efficacy of individual non-steroidal anti-inflammatory drugs (NSAIDs) when used in the management of osteoarthritis (OA) of the knee. (bris.ac.uk)
The MeSH heading "osteoarthritis" was combined with the generic names of the 17 non-aspirin NSAIDs licensed in the UK for the management of OA in general practice. (bris.ac.uk)
The search of Embase used the term "osteoarthritis" if present in the abstract, title or keywords, and was combined with the generic names of the 17 non-aspirin NSAIDs, only if they were mentioned in the title, abstract or keywords. (bris.ac.uk)
SELECTION CRITERIA: All double blind, randomised controlled trials, in the English language, comparing the efficacy of two non-aspirin NSAIDs in the management of osteoarthritis of the knee, were selected. (bris.ac.uk)
Most other NSAIDs provided similar pain relief and were associated with similar side effects and were therefore also considered good drug alternatives for osteoarthritis pain relief. (lu.se)
It was thereby concluded that topical NSAIDs should be considered a first-line treatment for knee osteoarthritis related pain. (lu.se)
Paracetamol (4000 mg/day) had a very low effect on osteoarthritis pain and was therefore considered a lot less effective than oral or topical NSAIDs. (lu.se)
Nonsteroidal anti-inflammatory drugs ( NSAIDs ) used for osteoarthritis (OA) in primary care may cause gastrointestinal or renal injury . (bvsalud.org)

WITHDRAWN: Non-aspirin, non-steroidal anti-inflammatory drugs for treating osteoarthritis of the knee. (bris.ac.uk)

We searched PubMed with worlds " osteoarthritis Acupuncture " in all fields and limit to " Clinical trial " and " Randomized Controlled Trial " from 2017 to 2022. (hindawi.com)
We searched Embase PICO with the following strategy that "osteoarthritis"/exp AND "acupuncture"/exp AND "clinical trial"/exp AND [2017-2022]/py. (hindawi.com)
Exercise is recommended as a core treatment for osteoarthritis in all clinical guidelines regardless of patient age, pain levels or disease severity. (racgp.org.au)
For people who suffer the pain and disability of knee osteoarthritis (OA), Tufts Medical Center not only has one of the nation's largest and most respected research programs, but its multidisciplinary physician-scientists also care for OA patients - streamlining the application of research findings to real-world clinical practice. (tuftsmedicalcenter.org)
The study aimed to evaluate the short-term clinical effect, therapeutic response rate (TRR%), and therapy safety of a single intra-articular autologous MFAT injection for symptomatic knee OA. (mdpi.com)
Identifying early stages of knee OA and modifiable risk factors is crucial to improving clinical decision-making and providing effective preventative strategies. (medscape.com)
The ultrastructural acupotomy therapy at the counter-Ashi points achieves the superior clinical efficacy on osteoarthritis of the knee as compared with the conventional acupuncture therapy. (unboundmedicine.com)
EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). (bmj.com)
Knee OA had to be supported by clinical and/or radiological evidence. (bmj.com)
In March 2021, Seikagaku obtained manufacturing and marketing approval in Japan based on the results of three Phase III Knee Osteoarthritis clinical studies conducted with Joyclu (SI-613) in Japan. (delveinsight.com)
Objective: To update the 1997 OMERACT-OARSI (Outcome Measures in Rheumatology-Osteoarthritis Research Society International) core domain set for clinical trials in hip and/or knee osteoarthritis (OA). (whiterose.ac.uk)
Only trials with subjects aged 16 years and over, with clinical and/or radiological confirmation of the diagnosis of OA knee were included. (bris.ac.uk)
Patients are initially assessed by using two validated clinical scales for knee pain: the visual analogue scale and the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) for pain and disability. (medscape.com)
Osteoarthritis is typically diagnosed on the basis of clinical and radiographic evidence. (medscape.com)
Currently, ultrasonography has no role in the routine clinical assessment of the patient with osteoarthritis. (medscape.com)

We conducted a single-center, randomized, controlled trial of arthroscopic surgery in patients with moderate-to-severe osteoarthritis of the knee. (nih.gov)

You can get osteoarthritis in other joints too, but knee osteoarthritis is one of most common types of osteoarthritis. (bupa.co.uk)
Being overweight puts more stress on your joints and can make osteoarthritis worse. (bupa.co.uk)
Osteoarthritis presents as normal age related changes in joints. (esht.nhs.uk)
Associated topics: joints,osteoarthritis - "Ruxiang (Gummi olibanum), the dried gum resin of Boswellia carterii (BC) [frankincense], has been used in traditional Chinese medicine to alleviate pain and inflammation for thousands of years. (oil-testimonials.com)
Associated topics: joints,osteoarthritis - "We have demonstrated that Boswellia frereana [frankincense] prevents collagen degradation, and inhibits the production of pro-inflammatory mediators and MMPs. (oil-testimonials.com)
Damage from mechanical stress with insufficient self repair by joints is believed to be the primary cause of osteoarthritis. (wikipedia.org)
Stiffness, pain, and swelling of the joints can be signs of osteoarthritis (OA). (lu.se)

Dr. Wang's team selected 204 participants with symptomatic and radiographic knee OA for their study and randomly placed them into two groups. (sciencedaily.com)
Although most points of criticism were answered by M Dougados and M Doherty it seems to me that treatment of knee OA with symptomatic slow acting drugs in osteoarthritis (SYSADOA) and cyclo-oxygenase-2 (COX-2) inhibitors needs to be discussed in a different way in the light of recent publications. (bmj.com)
Approximately 18.7 percent of symptomatic knee OA patients are female and 13.5 percent are male. (womenfitness.net)
Neil Segal, M.D., M.S., and colleagues at the University of Iowa Hospitals and Clinics followed 3,026 men and women ages 50-79 over a 30-month period in the Multicenter Knee Osteoarthritis Study (MOST) to assess whether knee extensor strength would predict OA that can be determined through X-ray or symptomatic knee OA. (womenfitness.net)
At the end of the 30-month period 10.1 percent of women and 7.8 percent of men displayed signs of symptomatic knee OA. (womenfitness.net)
Women in the top third of peak knee extensor strength had a lower incidence of symptomatic knee OA, while men with strong thigh muscles had only a slight advantage over men with weaker knee extensor strength. (womenfitness.net)
The H:Q ratios were not predictive of symptomatic knee OA in either men or women," added the researchers. (womenfitness.net)
These findings suggest that targeted interventions to reduce risk for symptomatic knee OA could be directed toward increasing knee extensor strength. (womenfitness.net)
Future studies focusing on causes of impaired proprioceptive accuracy in knee OA patients are also needed, taking into account that also the non-symptomatic knee may have proprioceptive impairments. (lu.se)
With a high probability of entering the US market in 2022, we expect CNTX-4975, out of all symptomatic emerging Knee Osteoarthritis therapies, to thwart its competition and capture a revenue of USD 700 million by 2032. (delveinsight.com)

To assess the association between intermediate and patient-centered outcomes and harms with physical therapy interventions in community-dwelling adults with chronic knee pain secondary to osteoarthritis and to examine validity and minimum clinically important differences of the tools for outcome measurement. (ahrq.gov)
Of these, 193 randomized controlled trials (RCTs) reported on knee pain, disability, quality of life, and functional outcomes after physical therapy interventions. (ahrq.gov)
Systematic reviews focusing on the relationship between impaired proprioceptive accuracy, knee pain and activity limitations and on the effect of interventions (in particular exercise therapy) on proprioceptive accuracy in knee OA are required. (lu.se)
It is likely that exercise interventions are underused in the management of established knee osteoarthritis symptoms. (cfp.ca)
Q What is the evidence for therapeutic interventions used in knee osteoarthritis (OA)? (bmj.com)
103 intervention trials were identified for the overall analysis that involved 33 interventions including non-pharmacological, pharmacological, intra-articular, and surgical treatments for knee OA. (bmj.com)

Fast Five Quiz: Knee Osteoarthritis Presentation and Diagnosis - Medscape - May 18, 2022. (medscape.com)
Computed tomography (CT) is rarely used in the diagnosis of primary osteoarthritis. (medscape.com)
Bone scans may be helpful in the early diagnosis of osteoarthritis of the hand. (medscape.com)

A knee brace for osteoarthritis is also known as an OA knee brace (OA is short for "osteoarthritis"), and it is sometimes called an unloading or off-loading brace. (breg.com)
The ideal knee brace for osteoarthritis pain will depend on your specific needs and general activity levels. (phc-online.com)

Of those enrolled, a total of 2,519 knees were included in the study of radiographic knee OA and 3,392 knees were evaluated for the combination of radiographic OA and symptoms of OA that include pain, aching or stiffness on most days of the month. (womenfitness.net)
Our results showed thigh muscle strength was not a significant predictor of radiographic knee OA," the authors were quoted as saying. (womenfitness.net)

Eligibility criteria for study selection Randomised trials comparing viscosupplementation with placebo or no intervention for knee osteoarthritis treatment. (bmj.com)
The COMPASS Osteoarthritis Knee Pain Trial is a multicenter, randomized (3:1), double-blind, placebo-controlled, single ascending-dose escalation study to assess the safety and efficacy of SL-1002 for the treatment of chronic knee pain associated with osteoarthritis in adult patients. (wjhl.com)
The safety of SL-1002 will be assessed throughout the study compared to placebo when used for treating chronic knee pain associated with osteoarthritis. (wjhl.com)
The COMPASS Osteoarthritis Knee Pain Trial is a multicenter, randomized, double-blind, placebo- CO ntrolled, single-ascending dose escalation study to assess the safety and efficacy of SL-1002 injectable for treat M ent of PA in a SS ociated with O steo A rthritis of the knee. (wjhl.com)
The researchers found that the NSAID etoricoxib (60 mg/day) and the NSAID diclofenac (150 mg/day) were the most effective anti-inflammatory drugs for osteoarthritis compared to placebo. (lu.se)

If you have stiffness in your knee in the morning, it will be for less than 30 minutes after you get up. (bupa.co.uk)

Both Tai Chi and physical therapy positively impact pain, function and other symptoms of knee osteoarthritis -- making Tai Chi a viable treatment alternative for people suffering with the degenerative disease, according to research presented this week at the American College of Rheumatology Annual Meeting in San Francisco. (sciencedaily.com)

There's no cure for osteoarthritis but there are things you can do to manage the condition and control your symptoms. (bupa.co.uk)
There is no cure for osteoarthritis. (medlineplus.gov)

We're also comparing alignment outcomes in computer-assisted versus conventional total knee arthroscopy, and investigating ways to enhance the effectiveness and longevity of prosthetic knee replacements by minimizing angulation errors. (tuftsmedicalcenter.org)
Our findings suggest that whole-body, physiological energy expenditure during recreational activities and time spent in physical activity were not associated with incident knee osteoarthritis outcomes," the authors write. (physiciansweekly.com)

Intra-articular injections of corticosteroid have been effective for flares of knee pain. (bmj.com)

Osteoarthritis mainly affects people over 50, and you're more likely to have it the older you are. (bupa.co.uk)
Knee osteoarthritis usually affects both of your knees and symptoms include the following. (bupa.co.uk)
Understanding how pain affects cognitive function and what factors influence this is really important and may help with improving cognitive function and quality of life for people with knee osteoarthritis. (news-medical.net)
A patient's gait, or how they walk, is an important predictor of the biomechanical load distribution that affects osteoarthritis (OA). (the-rheumatologist.org)
Osteoarthritis affects people in different ways, and not everyone has pain. (medlineplus.gov)

Does Loss of Skeletal Muscle Mass Increase the Risk of Knee OA? (the-rheumatologist.org)
Obesity is a well-known risk factor for knee osteoarthritis (OA), but data regarding the association of body composition (fat and muscle mass) with the risk of knee OA are lacking. (the-rheumatologist.org)
However exercise, including running in the absence of injury, has not been found to increase the risk of knee osteoarthritis. (wikipedia.org)

I read with great interest Dr Jawad's letter and the authors' reply about the EULAR recommendations for the management of knee osteoarthritis (OA). (bmj.com)
RCT evidence exists to support the statement that optimal management of knee OA requires a combination of non-pharmacological and pharmacological treatment options (eg, exercise programmes, physiotherapy, weight loss plus exercise, education, and wedged insoles give added benefit when used with an analgesic or non-steroidal anti-inflammatory drug [NSAID] regimen). (bmj.com)

This is often the cause of osteoarthritis in younger adults. (medlineplus.gov)

It is, however, still a challenge how we can identify patients but also how we can motivate these patients with early symptoms of osteoarthritis. (medscape.com)
What are the symptoms of osteoarthritis? (medlineplus.gov)

Studies done on subjects self-selected for exercise and followed for substantial periods of time show no evidence of accelerated development of osteoarthritis, provided injury is avoided. (cfp.ca)
Changes in sex hormone levels may play a role in the development of osteoarthritis, as it is more prevalent among post-menopausal women than among men of the same age. (wikipedia.org)

For severe cases, doctors go straight to knee replacement. (cbsnews.com)
You won't usually feel pain in your knee when you're in bed at night, unless you have severe osteoarthritis. (bupa.co.uk)
SL-1002 is currently being developed for the treatment of chronic knee pain associated with osteoarthritis (COMPASS Trial) and mild to severe limb spasticity (RAISE Trial). (wjhl.com)

For patients with knee and hip OA, the estimates of PASS were, respectively, 32.3 and 35.0 mm for pain, 32.0 and 34.6 mm for patient global assessment of disease activity, and 31.0 and 34.4 points for WOMAC function score. (bmj.com)

Some research shows that acupuncture may help relieve osteoarthritis pain. (medlineplus.gov)

The study suggested that social deprivation, interacting with chronic pain to impair cognitive ability, including memory and concentration, can make day-to-day activities, such as going shopping or doing housework, challenging for people with painful osteoarthritis. (news-medical.net)
While thigh muscle strength does not predict the presence of knee OA uncovered in x-rays, it does predict incidence of painful or stiff knee OA. (womenfitness.net)
No significant differences have been found between the most painful knee and the contralateral knee. (inderscience.com)
Do you have osteoarthritis in your knees and fear walking will make them painful? (scmp.com)
Patients with painful osteoarthritis of the knee. (astrazenecaclinicaltrials.com)

It says if you are having pain on the medial side of your knee, and you've been diagnosed with osteoarthritis, fill out the survey. (cbsnews.com)
We aim to: 1) study what information is needed for the case definition of work-related low back pain (LBP), lumbosacral radicular syndrome (LRS), subacromial pain syndrome (SAPS), carpal tunnel syndrome (CTS), lateral and medial elbow tendinopathy, and knee and hip osteoarthritis, and to 2) seek consensus among occupational health professionals/researchers regarding the case definitions of these work-related MSDs. (cdc.gov)
Consensus was only reached for work-related medial elbow tendinopathy, while the lowest agreement was found for knee osteoarthritis. (cdc.gov)

Introduction: Biomarkers to identify osteoarthritis (OA) patients at risk for disease progression are needed. (harvard.edu)

Objective To evaluate the effectiveness and safety of viscosupplementation for pain and function in patients with knee osteoarthritis. (bmj.com)
Objective: To give an overview of the literature on knee proprioception in knee osteoarthritis (OA) patients. (lu.se)
OBJECTIVE To determine whether physical exercise constitutes a benefit or a risk in the development and progression of knee osteoarthritis. (cfp.ca)

The researchers compared the effect of exercise therapy and no exercise among adults at least 45 years old with knee osteoarthritis, relying on individual participant data from the STEER OA study , a meta-analysis of 31 studies that involved 4,241 participants. (medscape.com)
After excluding studies that didn't report symptom duration, lacked a control group or consent, or focused on hip osteoarthritis, the researchers ended up with 10 studies involving 1,895 participants. (medscape.com)
Recent studies have already shown Tai Chi to be effective in treating the physical and mental symptoms associated with the disease, and researchers recently took this a step further to determine if Tai Chi would hold up against physical therapy -- a highly-regarded treatment for knee OA. (sciencedaily.com)
Tobias Bast, one of the researchers involved in the study, explains: 'Cognitive function is very important for daily activities, and people with knee pain often complain about impairments in cognitive functions. (news-medical.net)
GLA:D is an education and exercise program developed by researchers in Denmark for people with hip or knee osteoarthritis symptoms. (lifecare.com.au)
A 3-round international Delphi survey was then undertaken among patients, healthcare professionals, researchers, and industry representatives to gain consensus on key domains to be included in a core domain set for hip and/or knee OA. (whiterose.ac.uk)
Researchers aren't sure what causes osteoarthritis. (medlineplus.gov)

The efficacy of arthroscopic surgery for the treatment of osteoarthritis of the knee is unknown. (nih.gov)
Both Tai Chi and physical therapy positively impact pain, function and other symptoms of knee osteoarthritis - making Tai Chi a viable treatment alternative for people suffering with the degenerative disease, according to new research. (sciencedaily.com)
Knee OA causes long-term pain, and treatment can be challenging. (sciencedaily.com)
Knee braces specifically designed for osteoarthritis are a viable treatment option for many people. (breg.com)
We know that knee replacement currently is the most effective treatment, and refer patients to Orthopedics when appropriate. (tuftsmedicalcenter.org)
But we also offer non-operative, evidence-based treatment of knee OA, including weight management, physical therapy, and complementary and alternative medicine, particularly for patients who don't want surgery or wish to delay surgery. (tuftsmedicalcenter.org)
Current guidelines recommend patient education, exercise and weight loss as the first line of treatment for osteoarthritis. (lifecare.com.au)
To gain insights about the switching behavior between different types of pharmacological treatment for osteo¬arthritic-related pain over time, we analyzed long-term pharmacological treatment patterns for pain in patients with hip/knee OA before hip/knee TJR. (novapublishers.com)
systematic reviews, meta analyses, randomised controlled trials (RCTs), non-randomised controlled trials, and observational studies in English or other European languages were included if they assessed a treatment for pain or function, or both, in knee OA. (bmj.com)
Studies combining knee OA treatment with other types of OA were excluded. (bmj.com)
Other than surgical studies, most of the 33 identified treatment options for knee OA are supported by evidence from randomised controlled trials. (bmj.com)
Recent developments in our understanding of the neuroanatomy of the knee indicate that this treatment could be incredibly beneficial to the millions of patients who deal with chronic pain related to osteoarthritis of the knee. (wjhl.com)
Investigators plan to enroll 20 patients into the feasibility study, although as of now only 13 patients have actually received GAE treatment for OA of the knee. (medscape.com)
Overall physical function in the knee also improved after the procedure, and there were no serious adverse events related to the treatment," Bagla observed. (medscape.com)

Osteoarthritis is a common disorder that currently has no disease-modifying treatments," says Timothy McAlindon, MD , Chief of Rheumatology at Tufts Medical Center. (tuftsmedicalcenter.org)
Dr Niraj Vora - Looking for Tricompartmental Osteoarthritis Treatments in Mumbai, contact Dr Niraj Vora, specialist in Tricompartmental Osteoarthritis Treatments. (powershow.com)
What New Treatments Are There For Knee Osteoarthritis - Looking for Knee Osteoarthritis Treatments in Mumbai, contact Dr Niraj Vora, specialist in Knee Osteoarthritis Treatments. (powershow.com)
However, one may oversee the significant number of late-stage emerging therapies in the Knee Osteoarthritis pipeline, which are expected to enter the market soon and add to the cornucopia of available Knee Osteoarthritis treatments. (delveinsight.com)
Many treatments that are available to treat OA of the knee are either short-term or invasive," he noted. (medscape.com)
What are the treatments for osteoarthritis? (medlineplus.gov)

Ranging from the soft, breathable material found in the Freestyle™ OA to the more rigid designs of the Quantum and DUO braces, Breg osteoarthritis knee braces offer a variety of comfortable options depending on activity and instability levels. (breg.com)
Most private health insurance companies and Medicare offer coverage for osteoarthritis knee braces. (breg.com)
Breg OA knee braces, including the Freestyle OA, are commonly used by individuals with unicompartmental osteoarthritis. (breg.com)
Breg knee braces will not prevent or reduce all injuries. (breg.com)
When using Breg knee braces, it is important to keep dirt and grit out of the hinge mechanisms to maintain proper hinge mobility and brace function. (breg.com)
Dr Niraj Vora - Looking for a Knee braces for osteoarthritis in Mumbai, Book an appointment with Dr. Niraj Vora, Knee osteoarthritis specialist in Mumbai. (powershow.com)
We offer the best knee braces for osteoarthritis patients at great discount prices. (phc-online.com)

The hips, knees, hands and spine are commonly affected. (sciencedaily.com)

While previous studies have associated vitamin D deficiencies with an increased risk for severity of knee osteoarthritis, the new study is thought to be the first look at vitamin levels in relation to pain and disability. (nutraingredients-usa.com)
The good news is vitamin D levels are easily modifiable through safe, short-term exposure to sun and/or dietary intake, and may lessen the disability and pain of osteoarthritis. (nutraingredients-usa.com)
Knee OA is characterized by chronic pain and functional disability leading to substantial cost and mortality. (medscape.com)
MAIN MESSAGE Knee osteoarthritis is a major contributor to disability in seniors, and patients have expressed concern that continued exercise might lead to knee symptoms in later years. (cfp.ca)
Patients with established osteoarthritis are shown to derive uniform benefit to physical functioning, with reduction of pain and disability, using aerobic, muscle strengthening, aquatic, or physiotherapy-based exercise modalities. (cfp.ca)
Knee osteoarthritis (OA) is seen radiographically in 33% of the population older than 60 years of age, 1 and is responsible for a higher incidence of disability than any other chronic condition. (cfp.ca)
It is important to understand the role of exercise in the etiology and natural history of knee OA, one of the most prevalent conditions leading to disability in old age. (cfp.ca)
In the presence of knee OA, what is the effect of exercise on physical function, pain, and disability? (cfp.ca)
Osteoarthritis (OA) affecting the knees, the most prevalent type of OA afflicting Americans and the major cause of disability in the country, is suffered by millions. (phc-online.com)
Glucosamine sulphate and chondroitin sulphate have been safe and effective for treating pain and disability in a subset of patients with knee OA. (bmj.com)
Meanwhile, interim results clearly suggest that GAE can safely reduce pain and disability in patients with mild to moderate OA of the knee, as Bagla suggested. (medscape.com)
Osteoarthritis is the cause of about 2% of years lived with disability. (wikipedia.org)

Knee Osteoarthritis is quite a prevalent condition and constitutes a massive patient share. (delveinsight.com)

Individuals with hip and/or knee osteoarthritis symptoms, regardless of severity, can participate in GLA:D. If you have been diagnosed with patellofemoral pain (kneecap pain) or FAI (hip impingement), you may also benefit from the GLA:D program to prevent the onset of osteoarthritis. (lifecare.com.au)

New research suggests that chronic knee pain caused by osteoarthritis does not cause cognitive impairment in isolation, indicating that other factors like age, pain medication and socio-economic factors are likely to play a part. (news-medical.net)
The experimental model allows us to study the impact of chronic knee pain separately from other factors, which is impossible in people. (news-medical.net)
However, our findings in the experimental model, where we can study the impact of chronic knee pain separately from other factors, suggest that chronic knee pain alone is not sufficient to cause cognitive impairment. (news-medical.net)
Background: The Knee Injury and Osteoarthritis Outcome Score (KOOS) assesses acute and chronic knee injuries or early-onset osteoarthritis in young, active patients. (rti.org)

Based on these findings, Dr. Wang believes Tai Chi should be considered a beneficial therapeutic option to treat knee OA. (sciencedaily.com)
Regular land- or water-based therapeutic exercise for adults with knee osteoarthritis (OA). (racgp.org.au)
Guideline authors discussed therapeutic options for patients with hand, knee and hip OA in a session at the 2019 ACR/ARP Annual Meeting. (the-rheumatologist.org)

Knee osteoarthritis (OA) is a complex disease with several proposed mechanisms for both the initiation and progression of the disease. (uwaterloo.ca)
5) There is currently no evidence for a role of impaired proprioceptive accuracy in the onset or progression of radiographic osteoarthritis (ROA). (lu.se)
6) Impaired proprioceptive accuracy could be a risk factor for progression (but not for onset) of both knee pain and activity limitations in knee OA patients. (lu.se)

Knee osteoarthritis is a common health condition that causes pain and stiffness in your knee. (bupa.co.uk)
These changes affect how well your knee works and can lead to symptoms such as pain and stiffness. (bupa.co.uk)
Because of the pain, stiffness and swelling, you might not be able to move your knee as much or as easily as you would usually. (bupa.co.uk)
There are many things you can do to reduce the pain and stiffness in your knee, and to make living with osteoarthritis a bit easier. (bupa.co.uk)
A telephone screen at the beginning and end of the study was conducted to establish if frequent pain, aching or stiffness was present in the knee. (womenfitness.net)
When we looked at those who did not have regular knee pain at the beginning of the study, those who walked for exercise were less likely to develop regular knee pain and stiffness compared to those who did not walk. (scmp.com)

Dr. Neogi is a rheumatologist and epidemiologist whose research has focused primarily on knee osteoarthritis and gout, as well as methodologic issues of relevance for rheumatic diseases. (uwo.ca)

DENVER - Initiating exercise therapy early on in people who develop symptoms of knee osteoarthritis - even within their first year of pain or reduced function - is associated with modestly lower pain scores and modestly better function than in those whose symptoms have lasted longer, according to a study presented at the OARSI 2023 World Congress. (medscape.com)

This meta-analysis aims to assess the efficacy of acupuncture-related therapy on knee osteoarthritis (KOA) patients. (hindawi.com)
This research aimed to study the efficacy of a novel implant for osteoarthritic knees. (degruyter.com)
To compare the difference in the efficacy on osteoarthritis of the knee between the ultrastructural acupotomy therapy at the counter-Ashi points and the conventional acupuncture-moxibustion therapy. (unboundmedicine.com)

The elbow is not commonly affected in osteoarthritis. (medscape.com)

Osteoarthritis is a common cause of knee pain as people get older. (newscientist.com)
Osteoarthritis is common in the knees because the knees bear the weight of the body. (scoi.com)
Knee osteoarthritis (KOA) is the most common type of OA clinically [ 4 - 6 ]. (hindawi.com)
PARTIAL KNEE MENISCECTOMIES LINKED TO OSTEOARTHRITIS - A meniscal tear is one of the most common sports-related knee injuries in the United States. (powershow.com)
Osteoarthritis is the most common lifestyle disease in people over 65 years of age. (lifecare.com.au)
BACKGROUND: Osteoarthritis(OA) is the most common rheumatic disease. (bris.ac.uk)

Anatomy16

Organisms1

Diseases14

Chemicals and Drugs2

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Psychiatry and Psychology2

Phenomena and Processes7

Health Care2

Geographicals1

Prevalence of generalised osteoarthritis in patients with advanced hip and knee osteoarthritis: the Ulm Osteoarthritis Study. (1/3222)

Down regulation by iron of prostaglandin E2 production by human synovial fibroblasts. (2/3222)

Total knee replacement: should it be cemented or hybrid? (3/3222)

Expression of NG2/human melanoma proteoglycan in human adult articular chondrocytes. (4/3222)

Where does it hurt? Pain localization in osteoarthritis of the knee. (5/3222)

Longitudinal and cross-sectional variability in markers of joint metabolism in patients with knee pain and articular cartilage abnormalities. (6/3222)

Longitudinal analysis of the relationship between serum insulin-like growth factor-I and radiographic knee osteoarthritis. (7/3222)

1H NMR investigation of changes in the metabolic profile of synovial fluid in bilateral canine osteoarthritis with unilateral joint denervation. (8/3222)

Osteoarthritis, Knee

Osteoarthritis

Knee Joint

Osteoarthritis, Hip

Knee

Arthroplasty, Replacement, Knee

Knee Injuries

Knee Prosthesis

Cartilage, Articular

Menisci, Tibial

Arthralgia

Osteoarthritis, Spine

Range of Motion, Articular

Pain Measurement

Pain

Osteophyte

Tibia

Hand Joints

Anterior Cruciate Ligament

Patella

Synovial Fluid

Weight-Bearing

Injections, Intra-Articular

Chondrocytes

Synovial Membrane

Bone Malalignment

Finger Joint

Hip Joint

Severity of Illness Index

Biomechanical Phenomena

Joint Instability

Arthroscopy

Treatment Outcome

Stifle

Gait

Arthritis, Rheumatoid

Arthrography

Synovitis

Viscosupplementation

Hyaluronic Acid

Knee Dislocation

Arthroplasty, Replacement, Hip

Quadriceps Muscle

Medial Collateral Ligament, Knee

Viscosupplements

Joint Diseases

Prevalence of generalised osteoarthritis in patients with advanced hip and knee osteoarthritis: the Ulm Osteoarthritis Study. (1/3222)

Down regulation by iron of prostaglandin E2 production by human synovial fibroblasts. (2/3222)

Total knee replacement: should it be cemented or hybrid? (3/3222)

Expression of NG2/human melanoma proteoglycan in human adult articular chondrocytes. (4/3222)

Where does it hurt? Pain localization in osteoarthritis of the knee. (5/3222)

Longitudinal and cross-sectional variability in markers of joint metabolism in patients with knee pain and articular cartilage abnormalities. (6/3222)

Longitudinal analysis of the relationship between serum insulin-like growth factor-I and radiographic knee osteoarthritis. (7/3222)

1H NMR investigation of changes in the metabolic profile of synovial fluid in bilateral canine osteoarthritis with unilateral joint denervation. (8/3222)

Osteoarthritis

Knee effusion

Gene therapy for osteoarthritis

Knee cartilage replacement therapy

Zucapsaicin

Raju Vaishya

KuToo movement

Radiographic classification of osteoarthritis

Heparinoid

Arthritis

Pulsed electromagnetic field therapy

Chondroitin sulfate

Leslie Nielsen

Arthroscopic lavage

Bernt Haas

Parveen Babi

Joint replacement

Disease-modifying osteoarthritis drug

Paracetamol

Multiple epiphyseal dysplasia

2021 Shepherd Rams football team

German acupuncture trials

Ultrasound-guided hip joint injection

Balneotherapy

List of patient-reported quality of life surveys

Bath salts