Osteosarcoma, Juxtacortical
Parosteal osteosarcoma with myocardial metastasis 13 years after follow-up. (1/9)
PURPOSE: To report the case of a woman with a diagnosis of grade II (low grade) parosteal osteosarcoma with the occurrence of myocardial metastasis 13 years after resection, and to present a review of the existing literature on the subject. METHODS: Description of the case and review of the literature. CONCLUSION: The review leads to the conclusion that the occurrence of metastasis from parosteal osteosarcoma can occur in up to 38% of the cases, in spite of its relatively low aggressiveness. However, myocardial metastasis of a parosteal osteosarcoma is an event that was not found in the literature. (+info)Dedifferentiated parosteal osteosarcoma: the experience of the Rizzoli Institute. (2/9)
BACKGROUND: Dedifferentiated parosteal osteosarcoma (DPOS) is a variant of osteosarcoma in which a high-grade sarcoma coexists with a conventional parosteal osteosarcoma (c-POS), either at presentation (synchronous type) or at the time of recurrence (metachronous type). Only approximately 60 patients have been reported in the literature. The objective of this study was to analyze the clinicopathologic and radiographic features of a relatively large number of patients with DPOS in an attempt to define further the histologic and biologic behavior of this rare entity. METHODS: In a series of 120 patients with parosteal osteosarcoma who were seen at the Rizzoli Institute from 1958 to 2000, the authors identified 29 patients who were diagnosed with DPOS. The authors reviewed the clinical and radiologic features, histologic sections, treatments, and outcomes in this group of patients with DPOS. RESULTS: Twelve patients were male, and 17 patients were female. The patients ranged in age from 15 years to 65 yrs (average, 36 years; median, 32 years). One tumor involved the scapula, one involved the ilium, and another involved the skull. All 26 of the other tumors were located in the long bones (14 in the femur, 5 in the humerus, 3 in the tibia, 3 in the fibula, and 1 in the ulna). In 18 patients, radiographic areas of lucency were seen within an otherwise sclerotic lesion. Histologically, the dedifferentiated component was high-grade osteoblastic osteosarcoma in 14 patients, fibroblastic osteosarcoma in 10 patients, giant cell-rich osteosarcoma in 3 patients, and chondroblastic osteosarcoma in 2 patients. All tumors were Stage IIB, and invasion of the medullary canal was detected in 19 patients (65%). Twenty-eight patients underwent surgery, and 18 of those patients received chemotherapy (5 patients received neoadjuvant chemotherapy, and 13 patients received adjuvant). Nine patients were dead and 20 patients were alive (average follow-up, 107 months; range, from 3 months to 36 years) at the last follow-up. Of the nine patients who died, one patient received no treatment, five patients underwent surgery (with three patients achieving adequate margins) in combination with chemotherapy, and three patients underwent surgery only (with adequate margins achieved). Of the 20 patients who remained alive, 13 patients underwent surgery (with 10 patients achieving adequate margins) in combination with chemotherapy, whereas 7 patients underwent surgery only (all with adequate margins). Seven of the nine patients who died had widespread metastases. One patient died of causes unrelated to the tumor, and another patient died shortly after undergoing resection of a lesion in the skull. CONCLUSIONS: Dedifferentiation occurred in approximately 24% of patients with c-POS. The prognosis for patients with DPOS was better than the prognosis for patients with dedifferentiated central and dedifferentiated peripheral chondrosarcoma. (+info)A comparison of intramedullary and juxtacortical low-grade osteogenic sarcoma. (3/9)
(+info)MRI findings in parosteal osteosarcoma: correlation with histopathology. (4/9)
PURPOSE: To assess the role of magnetic resonance imaging (MRI), particularly signal intensity changes, in predicting the dedifferentiation of parosteal osteosarcoma, and to evaluate other factors that may affect grading on MRI. MATERIALS AND METHODS: MRI of 12 patients with parosteal osteosarcoma diagnosed on plain radiography were reviewed with regard to size, location, extent, soft tissue component, intramedullary invasion, and signal characteristics. The findings are correlated with histopathologic results. RESULTS: By histopathological examination there were 6 Grade I, 3 Grade II, and 3 Grade III tumors. Average size was 11 cm. All cases had a soft tissue component. Intramedullary extension was evident in 3/6 of the Grade I cases, 2/3 of the Grade II cases, and all (3/3) of the Grade III cases. T1-weighted images revealed lesions of marked hypointensity. Signal intensity on T2-weighted images varied with the presence of necrosis and hemorrhage in relation to size, regardless of the grade of the tumor. Contrast-enhanced images revealed enhancement of the solid components; no enhancement was observed in the necrotic or hemorrhagic parts. CONCLUSION: High and heterogeneous signal on T2-weighted images of Grade I, II, and III tumors is not specific for the dedifferentiated component, due to hemorrhage and necrosis in large masses. Therefore, high signal intensity on T2-weighted images is not always a reliable way to predict the grade of the tumor. Contrast enhanced T1-weighted images can be valuable to show the solid component in the heterogeneous areas on T2-weighted images, and can be useful in guiding the biopsy. (+info)Femoral parosteal osteosarcoma 18 years after its discovery: a case report. (5/9)
(+info)Peripheral ossifying fibroma and juxtacortical chondrosarcoma in cynomolgus monkeys (Macaca fascicularis). (6/9)
Literature on spontaneous primary bone tumors in nonhuman primates is sparse. This case report describes 2 different neoplastic bone lesions in 2 adult cynomolgus monkeys (Macaca fascicularis), including macroscopic, radiographic, histologic, and immunohistochemical findings. In one monkey, a firm mass located at the palatogingival junction of the left rostral maxilla was confirmed to be a peripheral ossifying fibroma in light of its histologic and immunohistochemical characteristics. In another monkey, a lobulated tumor at the right distal femur that radiographically showed moderate radiopacity with splotchy areas of mineralization was confirmed to be a juxtacortical chondrosarcoma on histologic examination. The 2 neoplastic bone lesions revealed rare histologic and immunohistochemical characteristics and contribute to the known tumor spectrum of cynomolgus monkeys. (+info)Local recurrence of a parosteal osteosarcoma 21 years after incomplete resection. (7/9)
(+info)Limb salvage in primary malignant bone tumors by intraoperative microwave heat treatment. (8/9)
OBJECTIVE: To use intraoperative microwave heat for the treatment of tumor-bearing bone in situ for limb-salvage in primary malignant bone tumor. PATIENTS AND METHODS: Twenty-five patients with malignant bone tumor received surgical protocol for limb-salvage by wide exposure and intraoperative microwave heat treatment of tumor bone in situ. The tumor was localized at distal femur in 16 patients, proximal tibia in 5, shaft of femur in 2, and illia in 2. RESULTS: The pathological diagnosis revealed osteosarcoma in 16 patients, parosteal osteosarcoma in 4, chondrosarcoma in 3, and leiomyosarcoma in 2. The stage of tumor was classified into IIB in 16 patients, IIA in 6, and IIIB in 3. The operative technique was wide exposure for tumor in soft tissues, protecting the surrounding normal tissue from heat injury by copper mesh, and heating tumor-bearing bone at 50 degrees C for 15 minutes. The patients were followed up from 4 to 180 months (mean, 63 months). The survival rate of 2, 5 and 10 years was 81.3%, 70.4%, and 53.8% respectively. The functional results were less than 50% in 4 patients, between 50% and 75% in 9, and more than 75% in 12, referred to the normal function of a normal limb. The complications consisted of infection in 4 patients, pathological fracture in 4, and separation of epiphysis in 1. Oncological results showed that local recurrences of tumor were in 4 patients, and 6 patients suffered from distant metastasis. CONCLUSION: The treatment is an alternative to replacement by prosthesis or allograft bridging techniques. (+info)Osteosarcoma, juxtacortical (also known as parosteal osteosarcoma) is a rare subtype of osteosarcoma, which is a type of bone cancer. It arises from the cambium layer of the periosteum, which is the highly vascular connective tissue that covers the outer surface of bones. Juxtacortical osteosarcomas typically develop on the surface of long bones, particularly around the knee region. They tend to grow slowly and have a lower risk of metastasis (spreading to other parts of the body) compared to conventional osteosarcomas.
Juxtacortical osteosarcomas are usually low-grade malignancies, meaning they are less aggressive and have a better prognosis than high-grade osteosarcomas. However, local recurrence is relatively common if the tumor is not completely removed during surgery. The primary treatment for juxtacortical osteosarcoma is surgical resection with wide margins, followed by close monitoring to ensure there is no evidence of recurrence or metastasis. Radiation therapy and chemotherapy may also be used in some cases, depending on the specific circumstances and individual patient needs.
Osteosarcoma is defined as a type of cancerous tumor that arises from the cells that form bones (osteoblasts). It's the most common primary bone cancer, and it typically develops in the long bones of the body, such as the arms or legs, near the growth plates. Osteosarcoma can metastasize (spread) to other parts of the body, including the lungs, making it a highly malignant form of cancer. Symptoms may include bone pain, swelling, and fractures. Treatment usually involves a combination of surgery, chemotherapy, and/or radiation therapy.
List of MeSH codes (C04)
International Classification of Diseases for Oncology
Juxtacortical Tumors: Background, Periosteal Chondroma, Periosteal Chondrosarcoma
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List of MeSH codes (C04) - Wikipedia
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Imaging in Calcium Pyrophosphate Deposition Disease: Overview, Radiography, Computed Tomography
Parosteal1
- [ 13 ] while investigating the presence of insulinlike growth factor 2 (IGF2) and mRNA-binding protein 3 (IMP3) in conventional intramedullary, parosteal, and periosteal osteosarcoma, found that the first demonstrated primarily cytoplasmic staining, whereas the second and third demonstrated nuclear staining. (medscape.com)
Chondrosarcoma2
- Like chondrosarcoma, osteosarcoma may be found on the surface of bone. (medscape.com)
- Solid primary lesions of the hyoid bone are exceedingly rare and the reported cases have included plasmacytoma, osteosarcoma, giant cell tumor, aneurysmal bone cysts, osteoma, chondroma, and chondrosarcoma. (ajnr.org)
Periosteal osteosarcoma2
- 9,10,12 Although signs of periosteal osteosarcoma may appear subtle on knee radiographs, magnetic resonance imaging (MRI) typically reveals a large, extraosseous soft-tissue mass with intramedullary invasion in some cases. (appliedradiology.com)
- 9-11 The absence of the more obvious cloud-like osseous matrix, sclerosis, and bone destruction usually associated with conventional osteosarcoma makes periosteal osteosarcoma a diagnostic challenge. (appliedradiology.com)
Bone7
- Osteosarcoma is a cancer of the bone that destroys tissue and weakens the bone. (cancer.net)
- Osteosarcoma most often starts in a leg bone around the knee joint, either at the femur, which is the lower end of the thigh bone, or the tibia, which is the upper end of the shin bone. (cancer.net)
- However, osteosarcoma can develop in any bone in the body. (cancer.net)
- Osteosarcoma (OS), referred to as osteogenic sarcoma, is the most common primary malignant bone tumor excluding plasma cell tumors. (ijofb.org)
- Periosteal (or juxtacortical) tumors as primary surface lesions arise from the periosteum or the soft tissue in the immediate proximity of the cortex of the bone. (openorthopaedicsjournal.com)
- 1 Although it is the third-most-common primary malignant bone tumor (following osteosarcoma and multiple myeloma) 2 and the second-most-common sarcoma arising in bone, 1 most cases occur in the pelvic bones, proximal femur, proximal humerus, distal femur, and the ribs. (ajnr.org)
- Multiple myeloma and osteosarcoma combined account for ~50% of all primary bone malignancies 7 . (radiopaedia.org)
Tumor2
- However, in most cases, it is impossible to determine whether the tumor arose from within the periosteum or from other juxtacortical connective tissues, with secondary involvement of the periosteum. (medscape.com)
- The type and subtype of osteosarcoma is determined by looking at the tumor cells through a microscope. (cancer.net)
Subtype2
- The most common subtype of osteosarcoma is conventional central osteosarcoma. (cancer.net)
- A subtype of nonconventional "surface" osteosarcomas, periosteal osteosarcomas are rare, malignant neoplasms representing about 1% of all osteosarcomas. (appliedradiology.com)
Malignant1
- Osteosarcoma (OS) arising from the jaw comprises 2.1% of all malignant oral and maxillofacial tumors. (ijofb.org)
Tumors2
- Juxtacortical tumors are composed of a variety of histologic tissue types. (medscape.com)
- Franchi et al, using immunohistochemistry and electron microscopy, found no significant differences among these tumors or between these surface variants and conventional osteosarcoma. (medscape.com)
Pediatric1
- This guide covers osteosarcoma that is diagnosed during childhood and adolescence, also called pediatric osteosarcoma. (cancer.net)
Periosteum1
- [ 5 ] Typically, it is centrally located, but it may be seen in a juxtacortical position, arising from the periosteum. (medscape.com)
Childhood1
- This is the first page of Cancer.Net's Guide to Osteosarcoma in Childhood and Adolescence. (cancer.net)
Primary1
- OSTEOSARCOMA Bimodal age distribution: Primary 10-20, secondary 50-70. (pdfslide.net)
Surface1
- Approximately 4% of osteosarcomas are located in a surface or juxtacortical location. (medscape.com)
Soft1
- We present a case of a bulky juxtacortical soft tissue mass in the thigh arising from a pagetic femur in a 62-year-old patient with polyostotic Paget's disease that was clinically and radiologically suspected to be a juxtacortical osteosarcoma . (lookfordiagnosis.com)
Makes1
- Osteosarcoma makes up 2% of all cancers in children ages 0 to 14 and 3% of all cancers in teens ages 15 to 19. (cancer.net)
Type1
- Each type of osteosarcoma has different subtypes. (cancer.net)
Account1
- They each account for less than 5% of all osteosarcomas. (cancer.net)
Periosteal3
- [ 13 ] while investigating the presence of insulinlike growth factor 2 (IGF2) and mRNA-binding protein 3 (IMP3) in conventional intramedullary, parosteal, and periosteal osteosarcoma, found that the first demonstrated primarily cytoplasmic staining, whereas the second and third demonstrated nuclear staining. (medscape.com)
- Periosteal osteosarcoma (PO) of the mandible. (jbstjournal.com)
- Imaging of periosteal osteosarcoma: Radiologic-pathologic comparison. (jbstjournal.com)
Types of osteosarcoma1
- These are the fastest growing types of osteosarcoma. (cancer.org)
Chondroblastic1
- Cartilaginous tumours and chondroblastic osteosarcomas, wild-type for IDH1 R132, were analysed for IDH2 (R172, R140) mutations. (nih.gov)
Lesions2
Occur in children and teens1
- Most osteosarcomas that occur in children and teens are high grade. (cancer.org)
20231
- In 2023, an estimated 1,000 people of all ages in the United States will be diagnosed with osteosarcoma. (cancer.net)
Histologic2
- 5. Juxtacortical osteosarcoma: a radiologic and histologic spectrum. (nih.gov)
- Also, there are juxtacortical or surface osteochondromas of bone, that arise just outside the cortex and are composed of different histologic types are reported in the literature [6,7]. (heraldopenaccess.us)
Subtypes1
- Each type of osteosarcoma has different subtypes. (cancer.net)
Develop in any bone1
- However, osteosarcoma can develop in any bone in the body. (cancer.net)
Benign1
- We tend to report a case of benign peripheral nerve schwannoma that greatly mimicked a juxtacortical osteosarcoma of femur. (jbstjournal.com)
Mesenchymal1
- Approximately 1200 mesenchymal tumours, including 220 cartilaginous tumours, 222 osteosarcomas and another ∼750 bone and soft tissue tumours, were screened for IDH1 R132 mutations, using Sequenom(®) mass spectrometry. (nih.gov)
Conventional1
- The most common subtype of osteosarcoma is conventional central osteosarcoma. (cancer.net)
Microscope2
- Based on how the cancer cells look under the microscope, osteosarcomas can be classified as high grade, intermediate grade, or low grade. (cancer.org)
- The type and subtype of osteosarcoma is determined by looking at the tumor cells through a microscope. (cancer.net)
Older adults1
- However, osteosarcoma can be diagnosed at any age, including in older adults. (cancer.net)
Secondary1
- However, in most cases, it is impossible to determine whether the tumor arose from within the periosteum or from other juxtacortical connective tissues, with secondary involvement of the periosteum. (medscape.com)
Commonly1
- Teens are the most commonly affected age group, but osteosarcoma can develop at any age. (cancer.org)
Typically1
- [ 5 ] Typically, it is centrally located, but it may be seen in a juxtacortical position, arising from the periosteum. (medscape.com)
Survival1
- It helps explain the number of people who are diagnosed with osteosarcoma and general survival rates. (cancer.net)
Cancers1
- Osteosarcoma makes up 2% of all cancers in children ages 0 to 14 and 3% of all cancers in teens ages 15 to 19. (cancer.net)
Next most common1
- The next most common place osteosarcoma begins is in the humerus. (cancer.net)
Spanish1
- Read about osteosarcoma in Spanish. (cancer.net)
High2
- There are many types of high-grade osteosarcomas (although the first 3 are the most common). (cancer.org)
- Most osteosarcoma in children are high grade. (cancer.net)