Otosclerosis
Stapes Surgery
Stapes
Hearing Loss, Conductive
Temporal Bone
Bone Conduction
Oval Window, Ear
Vestibular Evoked Myogenic Potentials
Ossicular Prosthesis
Ear Ossicles
Synostosis
Petrous Bone
Ear, Middle
Parathyroid hormone-parathyroid hormone-related peptide receptor expression and function in otosclerosis. (1/56)
The aim of this study was to investigate the possibility that an abnormality related to parathyroid hormone (PTH) action is involved in the increased bone turnover observed in otosclerosis. To do so, expression and function of the PTH-PTH-related peptide (PTHrP) receptor were studied in the involved tissue (stapes) and compared with that in control bone sample obtained from the external auditory canal (EAC) in the same patient in 10 cases of otosclerosis and in 1 case of osteogenesis imperfecta. PTH-PTHrP receptor expression was studied by RT-PCR of RNA prepared from cultured cells in three patients and RNA directly extracted from bone samples in four patients. PTH-PTHrP receptor function was assessed by measuring the stimulation of cAMP production by 0.8, 8, and 80 nM PTH in bone cell cultures in seven cases. Results showed that PTH-PTHrP receptor mRNA expression in the otosclerotic stapes was lower than that in EAC samples (P < 0.05), whereas it was higher in stapes than that in EAC in the case of osteogenesis imperfecta. cAMP production after PTH stimulation was lower in bone cells cultured from otosclerotic stapes compared with that in cells cultured from EAC (range of increase in stimulation: 0.8-4.5 and 1.5-7 in stapes and EAC bone cells, respectively, P < 0.05). In contrast, the stimulation of cAMP production by forskolin was not significantly different in otosclerotic stapes and EAC bone cells (range of increase in stimulation: 20.7-83.1 and 4.9-99.8 in stapes and EAC, respectively, P > 0.05). These results show a lower stimulation of cAMP production in response to PTH associated with a lower PTH-PTHrP receptor mRNA expression in pathological stapes from patients with otosclerosis compared with that in control EAC samples. This difference supports the hypothesis that an abnormal cellular response to PTH contributes to the abnormal bone turnover in otosclerosis. (+info)No evidence of measles virus in stapes samples from patients with otosclerosis. (2/56)
Otosclerosis is a localized bone dystrophy of unknown etiology mainly involving the stapes. The hypothesis of a persistent infection by the measles virus was based on the inconstant detection of the virus by various methods, including reverse transcription-PCR (RT-PCR) of patients' stapes samples. The aim of this work was to investigate the presence of the measles virus in stapedial otosclerosis foci by different sensitive methods. Pathologic stapes samples were obtained from 35 patients suffering from otosclerosis. Measles virus detection was performed by (i) cocultures of Vero cells and primary cell cultures of bone samples (n = 7), (ii) immunofluorescence study of these cocultures (n = 3), and (iii) RT-PCR on RNA directly obtained from fresh frozen samples (n = 28) and on RNA extracted from the primary cell cultures (n = 2). Viral genomic regions coding for N (nucleoprotein) and M (matrix) proteins were separately amplified. PCR sensitivity was optimized on the measles virus Edmonston strain. Glyceraldehyde-3-phosphate dehydrogenase mRNA was used as a marker of total RNA recovery. PCR products were tested by Southern blot hybridization technique to improve sensitivity and specificity. PCRs amplifying the M and the N protein genes were able to detect the control measles virus RNA at titers as low as 0.1 and 0.01 50% tissue culture infective dose, respectively. With these highly sensitive methods, we could not evidence the presence of the measles virus in any of our bone samples or primary bone cell cultures. Our results do not confirm the hypothesis of persistent measles virus infection in otosclerosis. (+info)Fenestration surgery for otosclerosis: CT findings of an old surgical procedure. (3/56)
Numerous attempts to deal surgically with otosclerosis were made before the current method of stapedectomy with stapes prosthesis was established. We report a case with unique CT findings of a patient who underwent fenestration surgery for otosclerosis in the early 1940s. Recognition of this old surgical procedure on the imaging scans may avoid misdiagnosis of labyrinthine fistulae or middle and inner ear malformations. (+info)A second gene for otosclerosis, OTSC2, maps to chromosome 7q34-36. (4/56)
Otosclerosis due to abnormal bone homeostasis of the otic capsule is a frequent cause of hearing loss in adults. Usually, the hearing loss is conductive, resulting from fixation of the stapedial footplate, which prevents normal ossicular vibration in response to sound. An additional type of sensorineural hearing loss may be caused by otosclerotic damage to the cochlea. The etiology of the disease is unknown, and both environmental and genetic factors have been implicated. Autosomal dominant inheritance with reduced penetrance has been proposed, but large families are extremely rare. To elucidate the pathogenesis of the disease, identification of the responsible genes is essential. In this study, we completed linkage analysis in a Belgian family in which otosclerosis segregates as an autosomal dominant disease. After excluding linkage to a known locus on chromosome 15 (OTSC1), we found linkage on chromosome 7q, with a multipoint LOD score of 3.54. Analysis of key recombinant individuals maps this otosclerosis locus (OTSC2) to a 16-cM interval on chromosome 7q34-36 between markers D7S495 and D7S2426. (+info)Postoperative complications in otospongiosis: usefulness of MR imaging. (5/56)
BACKGROUND AND PURPOSE: Sensorineural hearing loss (SNHL) is a rare complication of stapes surgery that may arise for many reasons. Usually, the pathogenesis of SNHL can be established by clinical and CT examinations. The purpose of this study was to evaluate the utility of MR imaging when CT findings are normal or not contributive. METHODS: Eleven patients with SNHL (in some instances, associated with vertigo) after stapedectomy, in whom CT showed no well-defined cause, were examined by MR imaging. RESULTS: MR studies established the additional findings of reparative intravestibular granuloma (n = 2), intralabyrinthine hemorrhage (n = 1), and bacterial labyrinthitis (n = 1). In five cases, MR findings were similar to CT findings. In two cases, CT and MR results were normal. Revision surgery was performed in five patients and confirmed the MR findings in each case. CONCLUSION: If CT is not contributive as to the origin of SNHL and vertigo occurring after stapes surgery, then MR imaging may be helpful in these patients. (+info)Linkage of otosclerosis to a third locus (OTSC3) on human chromosome 6p21.3-22.3. (6/56)
Clinical otosclerosis (OMIM 166800/605727) has a prevalence of 0.2-1% among white adults, making it the single most common cause of hearing impairment in this group. It is caused by abnormal bone homeostasis of the otic capsule with the consequent development of sclerotic foci that invade the stapedio-vestibular joint (oval window) interfering with free motion of the stapes. Impaired ossicular chain mobility results in a conductive hearing loss. We identified the first locus for otosclerosis (OTSC1) on chromosome 15 in 1998 and reported a second locus (OTSC2) on chromosome 7 last year. Here we present results of a genome wide linkage study on a large Cypriot family segregating otosclerosis. Results of this study exclude linkage to OTSC1 and OTSC2 and identify a third locus, OTSC3, on chromosome 6p. The defined OTSC3 interval covers the HLA region, consistent with reported associations between HLA-A/HLA-B antigens and otosclerosis. (+info)Stapes mobilization for otosclerotic deafness; the monitored peribasal technique. (7/56)
Direct surgical operation on the stapes footplate region in the treatment of hearing loss due to otosclerosis has been revived. In the last 100 cases of a total series of 600, the peribasal stapes mobilization (stapedolysis) technique was completely successful in 62 per cent, partially successful in 29 per cent and a failure in 9 per cent. Stapes mobilization requires precise microsurgical technique monitored by audiometry during the surgical procedure. It appears that mobilization is the preferred approach to the surgical treatment of otosclerosis, but fenestration of the vestibular labyrinth is an important secondary procedure in some cases. Successful restoration of hearing requires adequate mobility of the footplate coupled with physiological continuity of the drum ossicular chain mechanism. (+info)DEAFNESS. (8/56)
Dr T E T Weston describes his research into the effect of noise on hearing acuity and of deafness in the aged. He found that presbyacusis is associated with a multiplicity of factors, e.g. smoking, circulatory disturbance, urban domicile, heredity and occupational acoustic trauma.Miss W Galbraith describes the social implications of various degrees of deafness and the ways in which they can be overcome by such measures as lipreading, hearing aids and rehabilitation.Sir Terence Cawthorne discusses otosclerosis, nearly 1% of the population being affected by this type of deafness. He describes the modern operation of insertion of an artificial piston through the stapes and states that 90% of cases submitted to this operation will show immediate improvement, whilst 85% should still have retained this improvement at the end of two years. (+info)Otosclerosis is a medical condition that affects the bones in the middle ear. It is characterized by the abnormal growth and hardening (sclerosis) of the otosclerotic bone near the stapes footplate, one of the tiny bones in the middle ear (ossicles). This abnormal bone growth can cause stiffness or fixation of the stapes bone, preventing it from vibrating properly and leading to conductive hearing loss. In some cases, otosclerosis may also result in sensorineural hearing loss due to involvement of the inner ear structures. The exact cause of otosclerosis is not fully understood, but it is believed to have a genetic component and can sometimes be associated with pregnancy. Treatment options for otosclerosis include hearing aids or surgical procedures like stapedectomy or stapedotomy to bypass or remove the affected bone and improve hearing.
Stapes surgery, also known as stapedectomy or stapedotomy, is a surgical procedure performed to correct hearing loss caused by otosclerosis. Otosclerosis is a condition in which the stapes bone in the middle ear becomes fixed and unable to vibrate properly, leading to conductive hearing loss.
During stapes surgery, the surgeon makes an incision behind the ear and creates a small opening in the eardrum. The fixed stapes bone is then removed or modified, and a prosthetic device is inserted in its place to allow sound vibrations to be transmitted to the inner ear. In some cases, a piece of tissue or artificial material may be used to fill the space left by the removed bone.
Stapedectomy involves complete removal of the stapes bone, while stapedotomy involves making a small hole in the stapes bone and inserting a prosthetic device through it. Both procedures are typically performed on an outpatient basis and have a high success rate in restoring hearing. However, as with any surgical procedure, there are risks involved, including infection, permanent hearing loss, and balance problems.
The stapes is the smallest bone in the human body, which is a part of the middle ear. It is also known as the "stirrup" because of its U-shaped structure. The stapes connects the inner ear to the middle ear, transmitting sound vibrations from the ear drum to the inner ear. More specifically, it is the third bone in the series of three bones (the ossicles) that conduct sound waves from the air to the fluid-filled inner ear.
Conductive hearing loss is a type of hearing loss that occurs when there is a problem with the outer or middle ear. Sound waves are not able to transmit efficiently through the ear canal to the eardrum and the small bones in the middle ear, resulting in a reduction of sound that reaches the inner ear. Causes of conductive hearing loss may include earwax buildup, fluid in the middle ear, a middle ear infection, a hole in the eardrum, or problems with the tiny bones in the middle ear. This type of hearing loss can often be treated through medical intervention or surgery.
The temporal bone is a paired bone that is located on each side of the skull, forming part of the lateral and inferior walls of the cranial cavity. It is one of the most complex bones in the human body and has several important structures associated with it. The main functions of the temporal bone include protecting the middle and inner ear, providing attachment for various muscles of the head and neck, and forming part of the base of the skull.
The temporal bone is divided into several parts, including the squamous part, the petrous part, the tympanic part, and the styloid process. The squamous part forms the lateral portion of the temporal bone and articulates with the parietal bone. The petrous part is the most medial and superior portion of the temporal bone and contains the inner ear and the semicircular canals. The tympanic part forms the lower and anterior portions of the temporal bone and includes the external auditory meatus or ear canal. The styloid process is a long, slender projection that extends downward from the inferior aspect of the temporal bone and serves as an attachment site for various muscles and ligaments.
The temporal bone plays a crucial role in hearing and balance, as it contains the structures of the middle and inner ear, including the oval window, round window, cochlea, vestibule, and semicircular canals. The stapes bone, one of the three bones in the middle ear, is entirely encased within the petrous portion of the temporal bone. Additionally, the temporal bone contains important structures for facial expression and sensation, including the facial nerve, which exits the skull through the stylomastoid foramen, a small opening in the temporal bone.
Bone conduction is a type of hearing mechanism that involves the transmission of sound vibrations directly to the inner ear through the bones of the skull, bypassing the outer and middle ears. This occurs when sound waves cause the bones in the skull to vibrate, stimulating the cochlea (the spiral cavity of the inner ear) and its hair cells, which convert the mechanical energy of the vibrations into electrical signals that are sent to the brain and interpreted as sound.
Bone conduction is a natural part of the hearing process in humans, but it can also be used artificially through the use of bone-conduction devices, such as hearing aids or headphones, which transmit sound vibrations directly to the skull. This type of transmission can provide improved hearing for individuals with conductive hearing loss, mixed hearing loss, or single-sided deafness, as it bypasses damaged or obstructed outer and middle ears.
The oval window ( fenestra vestibuli ) is a small opening in the inner ear, specifically in the bony labyrinth of the temporal bone. It connects the middle ear to the vestibular system of the inner ear, more precisely to the vestibule. The oval window is covered by the base of the stapes, one of the three smallest bones in the human body, also known as the stirrup. This arrangement allows for the transmission of vibratory energy from the tympanic membrane (eardrum) to the inner ear, which is essential for hearing.
Vestibular Evoked Myogenic Potentials (VEMPs) are short-latency electromyographic responses recorded from the sternocleidomastoid or other neck muscles in response to intense, high-frequency bone conducted vibration or air-conducted sound. They reflect the activation of the vestibular afferents that innervate the otolithic organs (saccule and utricle) in response to linear acceleration and head tilt. VEMPs are used in clinical settings to assess the function of the vestibular system, particularly the sacculocollic reflex pathway, and can help diagnose various vestibular disorders such as superior canal dehiscence syndrome, vestibular neuritis, and Meniere's disease.
An ossicular prosthesis is a medical device used to replace one or more of the small bones (ossicles) in the middle ear that are involved in hearing. These bones, known as the malleus, incus, and stapes, form a chain responsible for transmitting sound vibrations from the eardrum to the inner ear.
An ossicular prosthesis is typically made of biocompatible materials such as ceramic, plastic, or metal. The prosthesis is designed to bypass damaged or missing ossicles and reestablish the connection between the eardrum and the inner ear, thereby improving hearing function. Ossicular prostheses are often used in surgeries aimed at reconstructing the middle ear, such as tympanoplasty or stapedectomy, to treat various types of conductive hearing loss.
The ear ossicles are the three smallest bones in the human body, which are located in the middle ear. They play a crucial role in the process of hearing by transmitting and amplifying sound vibrations from the eardrum to the inner ear. The three ear ossicles are:
1. Malleus (hammer): The largest of the three bones, it is shaped like a hammer and connects to the eardrum.
2. Incus (anvil): The middle-sized bone, it looks like an anvil and connects the malleus to the stapes.
3. Stapes (stirrup): The smallest and lightest bone in the human body, it resembles a stirrup and transmits vibrations from the incus to the inner ear.
Together, these tiny bones work to efficiently transfer sound waves from the air to the fluid-filled cochlea of the inner ear, enabling us to hear.
Synostosis is a medical term that refers to the abnormal or physiological fusion of adjacent bones. It's derived from two Greek words, "syn" meaning together and "osteon" meaning bone. In a normal physiological process, synostosis occurs during growth and development, where the growth of certain bones is stopped by the fusion of neighboring bones at specific sites known as sutures or fontanelles.
However, abnormal synostosis can occur due to various reasons such as injuries, infections, or genetic conditions. This can lead to restricted movement and growth disturbances in the affected area. Common examples include craniosynostosis, where the skull bones fuse prematurely, and syndactyly, where fingers or toes are fused together. Treatment for abnormal synostosis may involve surgery to correct the fusion and prevent further complications.
Ankylosis is a medical term that refers to the abnormal joining or fusion of bones, typically in a joint. This can occur as a result of various conditions such as injury, infection, or inflammatory diseases like rheumatoid arthritis. The fusion of bones can restrict movement and cause stiffness in the affected joint. In some cases, ankylosis can lead to deformity and disability if not treated promptly and effectively.
There are different types of ankylosis depending on the location and extent of bone fusion. For instance, when it affects the spine, it is called "ankylosing spondylitis," which is a chronic inflammatory disease that can cause stiffness and pain in the joints between the vertebrae.
Treatment for ankylosis depends on the underlying cause and severity of the condition. In some cases, physical therapy or surgery may be necessary to restore mobility and function to the affected joint.
The petrous bone is a part of the temporal bone, one of the 22 bones in the human skull. It is a thick and irregularly shaped bone located at the base of the skull and forms part of the ear and the cranial cavity. The petrous bone contains the cochlea, vestibule, and semicircular canals of the inner ear, which are responsible for hearing and balance. It also helps protect the brain from injury by forming part of the bony structure surrounding the brain.
The term "petrous" comes from the Latin word "petrosus," meaning "stony" or "rock-like," which describes the hard and dense nature of this bone. The petrous bone is one of the densest bones in the human body, making it highly resistant to fractures and other forms of damage.
In medical terminology, the term "petrous" may also be used to describe any structure that resembles a rock or is hard and dense, such as the petrous apex, which refers to the portion of the petrous bone that points towards the sphenoid bone.
The middle ear is the middle of the three parts of the ear, located between the outer ear and inner ear. It contains three small bones called ossicles (the malleus, incus, and stapes) that transmit and amplify sound vibrations from the eardrum to the inner ear. The middle ear also contains the Eustachian tube, which helps regulate air pressure in the middle ear and protects against infection by allowing fluid to drain from the middle ear into the back of the throat.
A hearing test is a procedure used to evaluate a person's ability to hear different sounds, pitches, or frequencies. It is performed by a hearing healthcare professional in a sound-treated booth or room with calibrated audiometers. The test measures a person's hearing sensitivity at different frequencies and determines the quietest sounds they can hear, known as their hearing thresholds.
There are several types of hearing tests, including:
1. Pure Tone Audiometry (PTA): This is the most common type of hearing test, where the person is presented with pure tones at different frequencies and volumes through headphones or ear inserts. The person indicates when they hear the sound by pressing a button or raising their hand.
2. Speech Audiometry: This test measures a person's ability to understand speech at different volume levels. The person is asked to repeat words presented to them in quiet and in background noise.
3. Tympanometry: This test measures the function of the middle ear by creating variations in air pressure in the ear canal. It can help identify issues such as fluid buildup or a perforated eardrum.
4. Acoustic Reflex Testing: This test measures the body's natural response to loud sounds and can help identify the location of damage in the hearing system.
5. Otoacoustic Emissions (OAEs): This test measures the sound that is produced by the inner ear when it is stimulated by a sound. It can help identify cochlear damage or abnormalities.
Hearing tests are important for diagnosing and monitoring hearing loss, as well as identifying any underlying medical conditions that may be causing the hearing problems.
Tinnitus5
- citation needed] Most patients with otosclerosis notice tinnitus (head noise) to some degree. (wikipedia.org)
- In otosclerosis, tinnitus may be a broad band hissing sound, discreet tones or pulses. (earsurgery.org)
- Tinnitus will go away in about half the cases of otosclerosis, when treated surgically. (earsurgery.org)
- Individuals with otosclerosis notice the inability to hear low-pitched sounds and whispers, experience dizziness, ringing (tinnitus), buzzing, or hissing sounds in the ears. (sheaclinic.com)
- One of the most common symptoms of otosclerosis is tinnitus (noise originating inside the ear). (targetwoman.com)
Conductive13
- The primary form of hearing loss in otosclerosis is conductive hearing loss (CHL) whereby sounds reach the ear drum but are incompletely transferred via the ossicular chain in the middle ear, and thus partly fail to reach the inner ear (cochlea). (wikipedia.org)
- Conductive hearing loss (CHL) in otosclerosis is caused by two main sites of involvement of the sclerotic (or scar-like) lesions. (wikipedia.org)
- Otosclerosis is well recognized as a cause of conductive hearing loss from fixation of the stapedial footplate in the oval window niche. (medscape.com)
- Otosclerosis is an osseous dyscrasia limited to the temporal bone that results in slow, progressive conductive hearing loss. (medscape.com)
- Otosclerosis is often associated with osteogenesis imperfecta (van der Hoeve syndrome) in a classic triad of hearing loss (conductive, mixed, or sensorineural), spontaneous bone fractures, and blue sclera. (medscape.com)
- Although about 10% of White adults have some otosclerosis (compared with 1% of Blacks), only about 10% of affected people develop conductive hearing loss. (msdmanuals.com)
- Otosclerosis often occurs as a unilateral mixed or conductive hearing loss. (omeka.net)
- Otosclerosis is an ear condition that is caused when an abnormal growth surrounds the vibrating bones of the middle ear and begins to cause conductive hearing loss. (thenewyorkhearingcenter.com)
- A hearing test will usually show signs of conductive hearing loss in the lower frequency tones, a hallmark of otosclerosis. (ccoasc.com)
- Growth on stapes, flat conductive heating loss with an elevated BC threshold at 2000 Hz ( bone conduction 2021-3-5 · On an audiogram, patients with otosclerosis commonly have conductive hearing loss with a drop in the bone-conduction threshold at 2,000 Hz, called a Carhart notch. (web.app)
- Type 3: meniere's disease + cochlear otosclerosis of conductive hearing loss on audiometry ✓+ schwartze sign. (web.app)
- Otosclerosis usually causes conductive hearing loss , which means there is a problem with how the ear transmits sound vibrations. (westtexasent.com)
- CONCLUSIONS: Persistent conductive hearing loss is common following stapedotomy for otosclerosis in patients with concomitant superior semicircular canal dehiscence. (beaumont.org)
Surgical treatment for otosclerosis2
- A few challenges remain, such as those patients enduring sensorineural hearing loss and unsteadiness, but many think surgical treatment for otosclerosis has reached perfection. (medscape.com)
- Historically, the most widely accepted surgical treatment for otosclerosis was microscopic stapes surgery [ 5 - 7 ]. (kbb-forum.net)
Symptoms3
- Hearing loss and sense of balance are the most severe symptoms caused by otosclerosis. (sheaclinic.com)
- The symptoms of otosclerosis are like those of other conditions, so a thorough examination by an otolaryngologist is essential in ruling out other problems and diagnosing the disease. (ccoasc.com)
- Because many symptoms seen with otosclerosis can be caused by other medical or ear-related conditions, it's important to be examined by an ENT (ear, nose, and throat) specialist, or otolaryngologist. (westtexasent.com)
People with otosclerosis3
- Perception of hearing loss is so slow that many people with otosclerosis only become aware of their hearing loss when friends or relatives call it to their attention. (earsurgery.org)
- Research suggests between 25 to 50% of people with otosclerosis have a family history of the condition. (balanceanddizziness.org)
- About 80 percent of people with otosclerosis will have the disease in both ears. (piedmontent.com)
Surgery19
- Otosclerosis surgery has developed through 3 distinct eras. (medscape.com)
- Some individuals with otosclerosis purchase a hearing aid because of health problems, age, or concerns regarding surgery. (earsurgery.org)
- Luryi AL, Schettino A, Michaelides EM, Babu S, Bojrab DI, Schutt CA. Outcomes After Tympanic Membrane Perforation During Primary Stapes Surgery for Otosclerosis. (rush.edu)
- Luryi AL, Schettino A, Bojrab DI, Babu SC, Michaelides EM, Bojrab DI, Schutt CA. Hearing Outcomes and Complications in Stapes Surgery for Otosclerosis Performed Under General or Local Anesthesia. (rush.edu)
- Luryi AL, Schettino A, Babu SC, Bojrab DI, Michaelides EM, Bojrab DI, Schutt CA. Association Between the Duration of Hearing Loss and Hearing Outcomes in Surgery for Otosclerosis. (rush.edu)
- There are inherent risks in any surgery, but left untreated, otosclerosis will only get worse. (ccoasc.com)
- There are several surgery techniques used to correct the hearing loss associated with otosclerosis. (piedmontent.com)
- Objective ： The aim of this study was to analyze the clinical features and the results after stapes surgery for patients with otosclerosis and congenital stapedial fixation. (ejao.org)
- 2006, we analyzed 41cases (30 patients) of stapes surgery done by one surgeon with otosclerosis and congenital stapedial fixation at Dong-A University Hospital. (ejao.org)
- Results： Forty-one cases (30 patients) were identified as 32 cases (23 patients) with otosclerosis and 9 cases (7 patients) with congenital stapedial fixation after stapes surgery. (ejao.org)
- And the BC thresholds in otosclerosis were improved after surgery. (ejao.org)
- To understand otosclerosis and stapes surgery, it is necessary to understand the structure and function of the ear. (glacierentclinic.com)
- The main options for otosclerosis include observation with repeated hearing tests, a hearing aid(s), or surgery. (westtexasent.com)
- Surgery for otosclerosis is called a stapedectomy or stapedotomy. (westtexasent.com)
- Outcomes of Stapedotomy in Patients With Concomitant Otosclerosis and Superior Semicircular Canal Dehiscence: Should a Radiographic Third-Window Be a Contraindication to Stapes Surgery? (beaumont.org)
- Radiographic superior semicircular canal dehiscence may not be an absolute contraindication to stapes surgery for otosclerosis. (beaumont.org)
- Sioshansi PC, Drury EE, Tu NC, Babu SC, Schutt CA. Outcomes of stapedotomy in patients with concomitant otosclerosis and superior semicircular canal dehiscence: should a radiographic third-window be a contraindication to stapes surgery? (beaumont.org)
- We reviewed studies on otosclerosis surgery and found that most of them focused on the efficacy of surgical treatment and comparison between surgical treatment methods (stapedectomy or stapedotomy, endoscopic or microscopic) [ 10 - 12 ]. (kbb-forum.net)
- We included information from patients meeting these inclusion criteria: between the ages of 18-65 with a presumable diagnosis of clinical otosclerosis from audiologic and radiological findings (i.e., normal external ear canal and normal otoscopic examination results, otherwise unexplained CHL, no stapes reflex and no history of ear infection) who underwent explorative tympanatomy and subsequently endoscopic stapedotomy surgery. (kbb-forum.net)
Causes otosclerosis3
- What Causes Otosclerosis? (ccoasc.com)
- Complete understanding of what causes otosclerosis is not known yet. (glacierentclinic.com)
- Transmission of the gene that causes otosclerosis is complex and not everyone who has the gene will develop the condition. (westtexasent.com)
Fitted in cases of otosclerosis1
- Hearing aids can be fitted in cases of otosclerosis. (earsurgery.org)
Otospongiosis2
- The term otosclerosis is something of a misnomer: much of the clinical course is characterized by lucent rather than sclerotic bony changes, so the disease is also known as otospongiosis. (wikipedia.org)
- this AC-notch is usually called a "cookie Otospongiosis also called otosclerosis is a primary localized disease of the otic capsule Biscuit focus (focus in the footplate, but free annular ligament) or Gelle test is positive and pure tone audiometry (PTA) shows normal BC a 28 Apr 2020 criteria for MFSNHL also known as ''cookie bite hearing loss. (web.app)
Middle ear16
- Otosclerosis is a condition of the middle ear where portions of the dense enchondral layer of the bony labyrinth remodel into one or more lesions of irregularly-laid spongy bone. (wikipedia.org)
- Otosclerosis is an abnormal bone growth in the middle ear that causes hearing loss . (medlineplus.gov)
- People who have otosclerosis have an abnormal extension of sponge-like bone growing in the middle ear cavity. (medlineplus.gov)
- Otosclerosis is the most common cause of middle ear hearing loss in young adults. (medlineplus.gov)
- When there is abnormal growth of the bone of the middle ear, otosclerosis is said to occur. (targetwoman.com)
- Otosclerosis (oh-toe-skler-OH-suhs) a complex disorder of abnormal bone growth in the middle ear. (balanceanddizziness.org)
- Otosclerosis involves the small bones of the middle ear - the malleus (2), the incus (3) and the stapes (4), as well as the bone that surrounds the inner ear. (balanceanddizziness.org)
- Hearing becomes impaired in otosclerosis when the stapes joins with surrounding bone of the middle ear. (balanceanddizziness.org)
- Otosclerosis is a condition that affects hearing as a result of hardening of a bone or bones in the middle ear. (piedmontent.com)
- Unlike hearing loss of the inner ear, hearing loss from otosclerosis in the middle ear is surgically reversible. (glacierentclinic.com)
- Otosclerosis describes a condition of abnormal bone growth around one of the three small bones in the middle ear space called the stapes. (westtexasent.com)
- An estimated 2.5 to 10 percent of adults have some otosclerosis in their middle ear. (westtexasent.com)
- Approximately 2.5-10% of adults develop otosclerosis in the middle ear. (lexiehearing.com)
- Otosclerosis occurs when abnormal remodeling happens to the bones in the middle ear. (lexiehearing.com)
- I visited a different ENT physician and learned that my otosclerosis had advanced from the middle ear to the inner ear. (cochlear.com)
- Otosclerosis is a unique disease affecting the otic capsule and middle ear bones, characterized by abnormal bone resorption and deposits in foci. (kbb-forum.net)
Percent of otosclerosis2
- On average, 60 percent of otosclerosis cases are genetic. (sheaclinic.com)
- Approximately 60 percent of otosclerosis has an underlying genetic cause. (westtexasent.com)
Stapedotomy for otosclerosis1
- Patients who underwent endoscopic stapedotomy for otosclerosis and met the inclusion criteria were included in this retrospective study. (kbb-forum.net)
Cochlear5
- The incidence of cochlear otosclerosis and that of cochlear otosclerosis resulting in clinically significant SNHL are unclear. (medscape.com)
- In addition, computed tomography (CT) scanning of the temporal bone can often demonstrate foci of demineralization in the otic capsule in cases of cochlear otosclerosis. (medscape.com)
- I now was diagnosed with bilateral sensorineural hearing loss due to cochlear otosclerosis. (cochlear.com)
- I was now suffering from rare severe bilateral cochlear otosclerosis. (cochlear.com)
- My physician suggested using a Cochlear brand device due to the severe spongy bone formation in my cochlea due to the otosclerosis. (cochlear.com)
Genetic8
- citation needed] Otosclerosis can be caused by both genetic and environmental factors, such as a viral infection (like measles). (wikipedia.org)
- Otosclerosis is one of many genetic and acquired conditions that affect the osseous structures. (msdmanuals.com)
- The measles virus plays an inciting role in patients with a genetic predisposition for otosclerosis. (msdmanuals.com)
- The exact cause of otosclerosis is not known, but evidence suggests a genetic link passed down from parent to child. (ccoasc.com)
- Otosclerosis can be caused by a genetic condition. (glacierentclinic.com)
- Otosclerosis is usually genetic and runs in families. (lexiehearing.com)
- Approximately 60% of otosclerosis cases have been linked to a genetic cause. (lexiehearing.com)
- My hearing journey began around the age of 12 when I lost a minor amount of hearing due to otosclerosis , a genetic disease. (cochlear.com)
Sensorineural5
- The mechanism of sensorineural hearing loss in otosclerosis is less well understood. (wikipedia.org)
- Less well recognized is that otosclerosis can involve other portions of the cochlea and produce sensorineural hearing loss (SNHL). (medscape.com)
- When otosclerosis spreads to the inner ear a sensorineural hearing impairment may result due to interference with the nerve function. (glacierentclinic.com)
- Patients with otosclerosis can also have inner ear hearing loss, called sensorineural hearing loss . (westtexasent.com)
- After Emily dealt with a long journey with hearing loss from otosclerosis, her pregnancy led to bilateral severe sensorineural hearing loss. (cochlear.com)
Word otosclerosis1
- The word otosclerosis comes from Greek. (balanceanddizziness.org)
Superior semicircul3
- OBJECTIVE: Review surgical outcomes of stapedotomy in patients with concomitant otosclerosis and superior semicircular canal dehiscence. (beaumont.org)
- PATIENTS: Patients with otosclerosis and radiographic superior semicircular canal dehiscence undergoing stapedotomy between 2008 and 2020. (beaumont.org)
- RESULTS: Twenty patients with otosclerosis and radiographic superior semicircular canal dehiscence underwent stapedotomy, 13 primary and 7 revision. (beaumont.org)
Manifest as early as age2
- Clinical otosclerosis can manifest as early as age 7-8 years but most commonly appears in persons aged 15-35 years. (medscape.com)
- Hearing loss caused by otosclerosis rarely may manifest as early as age 7 or 8, but most cases do not become evident until the late adolescent or early adult years, when slowly progressive, asymmetric hearing loss is diagnosed. (msdmanuals.com)
Pathophysiology1
- Loci include: The pathophysiology of otosclerosis is complex. (wikipedia.org)
Hearing Loss16
- Usually, symptomatic hearing loss from otosclerosis first develops early in the third decade of life, though onset can occur during childhood. (medscape.com)
- The most common morbidity from otosclerosis is hearing loss. (medscape.com)
- Women seek medical attention for hearing loss due to otosclerosis more frequently than men do. (medscape.com)
- Many individuals with otosclerosis compensate for their hearing loss by inadvertently learning to read lips. (earsurgery.org)
- Hearing loss in otosclerosis may be in one, or both ears. (earsurgery.org)
- How Does Otosclerosis Cause Hearing Loss? (sheaclinic.com)
- Otosclerosis is noticed to occur in persons with family history of hearing loss. (targetwoman.com)
- Fortunately, the hearing loss caused by otosclerosis is often reversible through a surgical procedure known as a laser stapedotomy. (thenewyorkhearingcenter.com)
- Sometimes hearing loss in otosclerosis is relatively mild and stays that way. (balanceanddizziness.org)
- While otosclerosis can lead to severe hearing loss, it rarely results in total deafness. (balanceanddizziness.org)
- To understand why otosclerosis causes hearing loss, it is important to have a basic understanding of how we hear. (balanceanddizziness.org)
- Gradually worsening hearing loss is the primary symptom of otosclerosis. (ccoasc.com)
- A woman with otosclerosis that becomes pregnant might find that her hearing loss becomes worse. (piedmontent.com)
- Unfortunately, there isn't any medicine that will help or stabilize the hearing loss in people who have otosclerosis. (piedmontent.com)
- Otosclerosis is a disease that causes progressive hearing loss and affects the bone of middle and inner ear. (glacierentclinic.com)
- Otosclerosis affects both ears approximately 70 percent of the time, however, the amount of hearing loss may not be the same in each ear. (westtexasent.com)
Dizziness1
- Far advanced otosclerosis can cause dizziness and affect balance, likely when abnormal bone growth extends into the inner ear. (balanceanddizziness.org)
Otic capsule3
- Otosclerosis is a genetically mediated metabolic bone disease that affects only the human otic capsule and ossicles. (medscape.com)
- [ 2 ] The histologic features of otosclerosis were demonstrated by Politzer, who identified the problem as an otic capsule disorder characterized by abnormal new bone formation. (medscape.com)
- Otosclerosis is a disease of the bone of the otic capsule that causes an abnormal accumulation of new bone within the oval window. (msdmanuals.com)
Postoperative4
- It has also been used for postoperative medical management of obliterative otosclerosis. (medscape.com)
- Furthermore, postoperative bone conduction (BC) gain was investigated by age groups in the cases with otosclerosis. (ejao.org)
- At 3-month postoperative follow-up, 24 of 31 cases (77%) with otosclerosis and 4 of 9 cases (44%) with congenital stapedial fixation had an AB gap of 10 dB or less, and 26 of 31 cases (83%) with otosclerosis and 7 of 9 cases (78%) with congenital stapedial fixation had an AB gap of 20 dB or less. (ejao.org)
- In otosclerosis, mean postoperative BC gain was 3.8 dB, and mean postoperative BC gains by age groups did not differ significantly (p>0.05). (ejao.org)
Patients8
- Ribonucleic acid of the measles virus has been found in stapes footplate in most patients with otosclerosis. (wikipedia.org)
- on the bone conduction audiogram, found in some patients with otosclerosis. (web.app)
- Outcomes of Stapedotomy in Patients With Concomitant Otosclerosis and " by Pedrom C Sioshansi, Emily E Drury et al. (beaumont.org)
- To demonstrate the contribution of high-resolution computed tomography (HRCT) images obtained preoperatively to diagnosing patients who underwent stapedotomy with a prediagnosis of otosclerosis in our clinic. (kbb-forum.net)
- We obtained data on 77 patients who underwent an exploratory tympanotomy with a prediagnosis of otosclerosis. (kbb-forum.net)
- According to Marshall's Classification on otosclerotic foci at HRCT, it was found that 55.2% (n=16) of patients had an otosclerosis focus on CT images, i.e., the sensitivity rate of the HRCT on the diagnosis of otosclerosis is 55.2%, statistically. (kbb-forum.net)
- The study aims to investigate the effect of stapedotomy on audiology measurements and the disease-specific health-related quality of life for patients with otosclerosis using the Danish Stapesplasty Outcome Test-25 as a quality of life measuring tool. (advancedotology.org)
- Hildebrandt M, Jensen MM, Larsen KD, Glad H, Djurhuus B. Hearing and disease-specific health-related quality of life in patients with otosclerosis after stapedotomy - a trial of the SPOT-25 questionnaire. (advancedotology.org)
Ears2
- Otosclerosis affects both ears (bilateral) in about 70 to 80% of cases. (balanceanddizziness.org)
- If otosclerosis affects both ears, typically the surgeon will choose to operate on the worst-hearing ear first and will not operate on both ears at the same time. (westtexasent.com)
Inner ear3
- Otosclerosis is a disease in the ear that is a form of abnormal bone growth in the middle and inner ear. (sheaclinic.com)
- Otosclerosis is a condition where there is an overgrowth of bone in the space behind the eardrum and the inner ear. (acadianent.com)
- For example, research has shown a decline in otosclerosis among people vaccinated against measles, stress fractures to the bony tissue around the inner ear, and autoimmunity disorders. (lexiehearing.com)
Sodium fluoride2
- Doses of oral sodium fluoride are known to improve otosclerosis. (targetwoman.com)
- Some medicines such as sodium fluoride or bisphosphonate supplements have been reported to limit the worsening of otosclerosis, but there is no definitive evidence of preventing its progression. (westtexasent.com)
Computed tomography1
- Diagnostic performance of high resolution computed tomography in otosclerosis. (medscape.com)
Occurs4
- Otosclerosis is much more common in whites than in persons of other races: Histologic otosclerosis occurs in 10-20% of whites but in only about 1% of people of African descent. (medscape.com)
- Otosclerosis - the immobilization of the stapes bone - occurs slowly. (earsurgery.org)
- Researchers also think that the imbalance of certain immune-system cells , such as cytokines responsible for bone remodeling, can cause abnormal remodeling that occurs in otosclerosis. (lexiehearing.com)
- In otosclerosis, an accumulation of abnormal growth of bone occurs on the stapes . (lexiehearing.com)
Vaccinated against measles1
- Populations that have been vaccinated against measles had a significant reduction in otosclerosis. (wikipedia.org)
Gene5
- One genome-wide analysis associates otosclerosis with variation in RELN gene. (wikipedia.org)
- Evidence has recently mounted that the measles virus plays an important role in gene activation of otosclerosis. (medscape.com)
- Otosclerosis is a complex disease with rare autosomal dominant forms caused by a single gene. (msdmanuals.com)
- By linkage analysis, the localization of an otosclerosis gene is chromosome 15q25-q26. (msdmanuals.com)
- however, not everyone who carries the gene will have otosclerosis. (lexiehearing.com)
Stapes bone1
- The stapes bone is the final link in the hearing chain of bones and is the bone most often affected by otosclerosis. (piedmontent.com)
Tends to run in families2
- Otosclerosis tends to run in families, and half of all cases are inherited. (msdmanuals.com)
- Otosclerosis is inherited and tends to run in families although you may not know who in your family passed it on to you. (piedmontent.com)
Oval window2
- This involvement of the oval window forms the basis of the name fenestral otosclerosis. (wikipedia.org)
- The most common location of involvement of otosclerosis is the bone just anterior to the oval window at a small cleft known as the fissula ante fenestram. (wikipedia.org)
Clinical1
- Several genes are associated with familial otosclerosis with varied clinical signs. (rush.edu)
Vertigo2
- Review of the recent literature reveals that there have been no cases reported in which vertigo accompanied by otosclerosis has been successfully treated by stapes mobilization, although Jordan presented one such case in his course on Ménière's disease at the 1957 meeting of the American Academy of Ophthalmology and Otolaryngology. (jamanetwork.com)
- Jack mentioned relief of vertigo by stapedectomy, but he did not state that it was accompanied by otosclerosis. (jamanetwork.com)
Pregnancy2
- Pregnancy can cause otosclerosis to advance more quickly. (balanceanddizziness.org)
- Unbeknownst to me, otosclerosis accelerates during pregnancy, through unknown hormonal mechanisms. (cochlear.com)
Worse3
- Otosclerosis may slowly get worse. (medlineplus.gov)
- Otosclerosis gets worse without treatment. (medlineplus.gov)
- The audiogram with worse air-conduction thresholds at low frequencies, below 1-2 kHz, is typical for otosclerosis 1). (web.app)
Adults1
- Otosclerosis is one of the most common causes of hearing impairment in young adults. (balanceanddizziness.org)
Diagnosis1
- While HRCT has low diagnostic accuracy in diagnosing otosclerosis, preoperatively obtained HRCT imaging is still essential for differential diagnosis and evaluation of anatomical variations. (kbb-forum.net)
Cases5
- In many cases, persons suffering from otosclerosis are not even aware of their condition and do not seek medical help. (targetwoman.com)
- In most of the cases, stapedectomy benefits the patient suffering from otosclerosis. (targetwoman.com)
- Mild cases of otosclerosis can be corrected with a hearing aid designed to amplify sounds. (ccoasc.com)
- Bone conduction hearing devices or a bone-anchored hearing aid may help hear better in otosclerosis cases. (lexiehearing.com)
- Lempert J. Improvement of hearing in cases of otosclerosis: New one-stage technique. (ijorl.com)