POEMS Syndrome
Giant Lymph Node Hyperplasia
Poetry as Topic
Picibanil
Polyneuropathies
Paraproteinemias
Melphalan
Paraneoplastic Syndromes
Encyclopedias as Topic
Human herpesvirus 8 infection in patients with POEMS syndrome-associated multicentric Castleman's disease. (1/80)
The polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes (POEMS) syndrome is a rare multisystemic disorder associated with osteosclerotic myeloma and multicentric Castleman's disease (MCD). Human herpesvirus type 8 (HHV-8) DNA sequences have been detected in lymph nodes of about 40% of human immunodeficiency virus (HIV)-negative patients with MCD, and in bone marrow stromal cells of patients with multiple myeloma. Considering these data, we investigated the presence of HHV-8 in 18 patients with POEMS syndrome (9 with MCD), by nested polymerase chain reaction (N-PCR) to detect DNA sequenses in various cells and tissues obtained by biopsy or at autopsy (13 patients, of whom 7 had MCD), and by an immunofluorescence assay to detect anti-HHV-8 IgG antibodies in blood (18 patients, of whom 9 had MCD). Detection of HHV-8 DNA was performed using three different N-PCR, targeting nonoverlapping regions in open reading frame (ORF) 25 and ORF26. Seven of 13 (54%) POEMS patients had HHV-8 DNA sequences in their tissues, as assessed by all three N-PCR, and 9 of 18 (50%) had circulating anti-HHV-8 antibodies. HHV-8 was mainly detected in the subset of POEMS patients with MCD (6 of 7 [85%] for DNA sequences; 7 of 9 [78%] for antibodies). The percentage of positive N-PCR was higher in lymph nodes than in bone marrow samples (P <.02). Sequencing of amplicons showed a homogeneous restricted variability in the ORF26 region, characteristic of the minority subgroup B defined by Zong, and responsible for isoleucine and glycine substitutions at amino acid positions 134 and 167. These findings strongly suggest an association of HHV-8 infection with POEMS syndrome-associated MCD. (+info)A spectrum of clinicopathological features of nephropathy associated with POEMS syndrome. (2/80)
BACKGROUND: In POEMS syndrome, substantial involvement of the kidney can occur and is reflected by proteinuria, haematuria, renal dysfunction, and renal failure requiring dialysis therapy. The mechanism by which renal dysfunction is induced and progresses to end-stage renal disease remains obscure. A pathogenic role of cytokines and growth factors has recently been implicated. METHODS: We reviewed cases of 52 Japanese patients with confirmed renal pathology who were reported in the literature, and personally analysed renal tissues from 22 subjects including nine patients of our own. Interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) were measured in our cases. RESULTS: Despite relatively mild renal symptomatology, about half of the cases had azotaemia with creatinine levels above 1.5 mg/dl and the BUN/creatinine ratio markedly raised by volume contraction or wasting. One-tenth of patients were placed on haemodialysis because of advanced or end-stage renal disease. Bilateral and unilateral contracted kidneys were found in four and two cases respectively. Pathological analyses disclosed two major changes: glomerular alterations and endarteritis-like lesions of renal small arteries. The former included glomerular enlargement, cellular proliferation, mesangiolysis and marked swelling of endothelial-mesangial cells. This structural disorganization led to a reduction in renal function to some degree by impairing the glomerular circulation. Vasculopathy of the small artery probably resulted in progressive renal damage and ultimately to kidney contraction. Serum IL-6 was elevated in about 40% of cases. IL-6 levels were found to be high in the ascites of three patients who were examined. In different studies, an increased level of VEGF was found in the peripheral blood (75-100%; overall 92.3%), but no apparent correlation with glomerular alterations was observed. CONCLUSION: POEMS nephropathy can be one cause of end-stage renal disease with variable intrarenal pathological changes of a microangiopathic nature which have differential influences on renal function. A pathogenic role for VEGF in POEMS syndrome appears to be likely, but its causal relation to the nephropathy awaits further investigation. (+info)VEGF is causative for pulmonary hypertension in a patient with Crow-Fukase (POEMS) syndrome. (3/80)
We report a case of Crow-Fukase (POEMS) syndrome associated with pulmonary hypertension (PH). In this case, the concentration of vascular endothelial growth factor (VEGF) was extremely high in the serum, and the levels of IL-1beta, IL-6, TNF-alpha, and thiamine, which were thought in past reports to be mediators of PH in Crow-Fukase syndrome, were normal. After prednisolone therapy, PH disappeared with a dramatic decrease in serum VEGF. Our results suggest that VEGF is closely correlated with PH in Crow-Fukase syndrome. (+info)Crow-Fukase syndrome with ischemic cardiomyopathy. (4/80)
A 31-year-old man was admitted to our hospital for further evaluation of heart failure symptoms. Crow-Fukase syndrome was diagnosed on the basis of findings of polyneuropathy, hepatomegaly, monoclonal hypergammaglobulinemia, and hypertrichosis. Dipyridamole-stress thallium-201 perfusion imaging, contrast left ventriculography, and coronary angiography revealed a markedly dilated and dysfunctioning left ventricle, extensive reversible ischemia with fixed defect, and multiple coronary lesions. Histopathology of myocardial biopsy specimens demonstrated ischemia-induced myocardial necrosis. These findings suggested that ischemic cardiomyopathy, probably due to inflammatory reactions of coronary arteries in Crow-Fukase syndrome, was responsible for the heart failure symptoms and left ventricular dysfunction in this patient. (+info)Successful treatment of POEMS syndrome with autologous hematopoietic progenitor cell transplantation. (5/80)
POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) is a plasma cell dyscrasia that differs substantially from classic multiple myeloma. It is often associated with disabling polyneuropathy in younger patients. Current therapeutic approaches are frequently inadequate and leave many patients wheelchair-bound with significant deterioration in quality and length of life. We present the case of a young man with progressive disease despite conventional therapeutic approaches. We describe a novel approach to treatment with a bone-seeking radiopharmaceutical, samarium-153 ethylene diamine tetramethylene phosphonate ((153)Sm-EDTMP), followed by myeloablative chemotherapy with autologous hematopoietic progenitor cell reconstitution. This approach resulted in regression of the organomegaly and skin changes and in neurologic improvement both clinically and electrophysiologically. The patient progressed from being wheelchair-bound to independent ambulation. An aggressive approach should be considered in patients with POEMS syndrome in whom standard therapeutic measures fail. (+info)An autopsy case of POEMS syndrome with a high level of IL-6 and VEGF in the serum and ascitic fluid. (6/80)
A 45-year-old woman was hospitalized because of systemic edema and peripheral nerve impairment. The patient had complications of organomegaly, endocrinopathy, and monoclonal gammmopathy, and was diagnosed with POEMS syndrome based on these characteristic signs and symptoms. Interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) levels in the serum and ascitic fluid were high. Many of the patient's symptoms were ameliorated, and IL-6 and VEGF levels in the serum and ascitic fluid decreased slightly during chemotherapy, but she died of respiratory failure. Autopsy revealed severe systemic edema and macroscopic hemorrhage in many organs, but VEGF and IL-6 producing cells were not found. (+info)High-dose therapy and autologous blood stem cell transplantation in POEMS syndrome. (7/80)
We treated 5 patients with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome and multifocal bone lesions or diffuse bone marrow plasmacytic infiltration with high-dose therapy (HDT) and autologous blood stem cell transplantation. In all cases, the treatment produced remission of plasma cell proliferation associated with marked improvement in the patients' performance status, neurologic symptoms, and other manifestations of the syndrome. HDT with stem cell support should be investigated further as a therapeutic option in patients with POEMS syndrome and disseminated plasma cell dyscrasia. (+info)Crow-Fukase syndrome associated with high-output heart failure. (8/80)
A 64-year-old woman was admitted with systemic edema and exertional dyspnea. High-output heart failure was diagnosed by right heart catheterization and she was treated with diuretics. After 3 weeks, her symptoms disappeared but a high cardiac output state persisted. A diagnosis of Crow-Fukase syndrome was made based on the presence of polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes. Her serum vascular endothelial growth factor (VEGF) level was markedly elevated after recovery from heart failure. We suspect that an elevated VEGF level and a high cardiac output state may play a role in the pathogenesis of heart failure in Crow-Fukase syndrome. (+info)POEMS syndrome is a rare and complex disorder that affects multiple parts of the body. The name POEMS is an acronym that stands for the following symptoms: Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, and Skin changes.
Here's a brief definition of each component of the syndrome:
* Polyneuropathy: This refers to damage to the peripheral nerves that can cause symptoms such as numbness, tingling, pain, and weakness in the arms and legs.
* Organomegaly: This means enlargement of organs, such as the liver, spleen, or lymph nodes.
* Endocrinopathy: This refers to abnormalities in hormone-producing glands, which can lead to symptoms such as diabetes, low testosterone levels, and thyroid dysfunction.
* Monoclonal gammopathy: This is an abnormal production of a single type of immunoglobulin (a protein produced by the immune system) in the bone marrow.
* Skin changes: These can include skin thickening, darkening, or redness, as well as skin lesions.
POEMS syndrome is typically caused by an underlying plasma cell disorder, such as multiple myeloma or a related condition called Waldenstrom macroglobulinemia. Treatment for POEMS syndrome usually involves addressing the underlying plasma cell disorder, as well as managing specific symptoms of the syndrome.
Osteosclerosis is a medical term that refers to an abnormal thickening and increased density of bone tissue. This condition can occur as a result of various diseases or conditions, such as certain types of bone cancer, Paget's disease of bone, fluoride poisoning, or chronic infection of the bone. Osteosclerosis can also be seen in some benign conditions, such as osteopetrosis, which is a rare genetic disorder characterized by an excessively hard and dense skeleton.
In some cases, osteosclerosis may not cause any symptoms and may only be discovered on X-rays or other imaging studies. However, in other cases, it can lead to complications such as bone pain, fractures, or deformities. Treatment for osteosclerosis depends on the underlying cause of the condition and may include medications, surgery, or other therapies.
Giant lymph node hyperplasia, also known as Castlemans disease, is a rare benign condition characterized by the abnormal enlargement of lymph nodes due to an overgrowth of cells. It can affect people of any age but is more commonly seen in young adults and children.
The enlarged lymph nodes caused by this condition are typically round, firm, and mobile, and they may be found in various locations throughout the body, including the neck, chest, abdomen, and pelvis. In some cases, the enlarged lymph nodes may cause symptoms such as pain, pressure, or difficulty swallowing, depending on their location.
Giant lymph node hyperplasia can be classified into two main types: unicentric and multicentric. Unicentric Castleman's disease affects a single group of lymph nodes, while multicentric Castleman's disease affects multiple groups of lymph nodes throughout the body.
The exact cause of giant lymph node hyperplasia is not fully understood, but it is thought to be related to an overactive immune response. In some cases, it may be associated with viral infections such as HIV or HHV-8. Treatment for this condition typically involves surgical removal of the affected lymph nodes, along with medications to manage any associated symptoms and prevent recurrence.
I'm sorry for any confusion, but "Poetry as Topic" is not a term that has a specific medical definition. It seems to be a subject that falls under the humanities or arts, rather than being a medical concept. Poetry can sometimes be used in therapeutic settings as a form of expressive art therapy, but it is not a medical diagnosis or treatment. If you have any questions related to medicine or health, I'd be happy to try and help answer those for you!
A syndrome, in medical terms, is a set of symptoms that collectively indicate or characterize a disease, disorder, or underlying pathological process. It's essentially a collection of signs and/or symptoms that frequently occur together and can suggest a particular cause or condition, even though the exact physiological mechanisms might not be fully understood.
For example, Down syndrome is characterized by specific physical features, cognitive delays, and other developmental issues resulting from an extra copy of chromosome 21. Similarly, metabolic syndromes like diabetes mellitus type 2 involve a group of risk factors such as obesity, high blood pressure, high blood sugar, and abnormal cholesterol or triglyceride levels that collectively increase the risk of heart disease, stroke, and diabetes.
It's important to note that a syndrome is not a specific diagnosis; rather, it's a pattern of symptoms that can help guide further diagnostic evaluation and management.
Chylothorax is a medical condition characterized by the accumulation of lymphatic fluid called chyle in the pleural space, which is the space between the lungs and the chest wall. Chyle is a milky-white fluid that contains nutrients, electrolytes, and immune cells, and it is normally transported through the thoracic duct to the bloodstream.
Chylothorax can occur due to various reasons, such as trauma, surgery, tumors, or congenital abnormalities that disrupt the normal flow of chyle. As a result, chyle leaks into the pleural space, causing symptoms such as cough, chest pain, difficulty breathing, and fever.
The diagnosis of chylothorax is usually made through imaging studies such as chest X-ray or CT scan, and confirmed by analyzing the fluid for the presence of chylomicrons, which are lipid particles found in chyle. The treatment options for chylothorax include dietary modifications, such as a low-fat diet with medium-chain triglycerides, chest tube drainage, and surgical interventions such as thoracic duct ligation or pleurodesis.
Picibanil is not a commonly used medical term, and it may be more familiar as the brand name for a specific preparation of Group A Streptococcus OK-432. It is an immunotherapeutic agent that has been used in Japan for the treatment of certain types of cancer, such as nasopharyngeal carcinoma and soft tissue sarcoma.
Group A Streptococcus OK-432 is a weakened form of a bacterium that causes strep throat. When administered, it stimulates the immune system to produce cytokines, which are substances that help regulate the immune response. This can enhance the body's ability to fight off cancer cells and potentially slow or stop tumor growth.
It is important to note that Picibanil/OK-432 is not approved for use in the United States and its effectiveness as a cancer treatment has not been extensively studied outside of Japan.
Polyneuropathy is a medical condition that refers to the damage or dysfunction of peripheral nerves (nerves outside the brain and spinal cord) in multiple areas of the body. These nerves are responsible for transmitting sensory, motor, and autonomic signals between the central nervous system and the rest of the body.
In polyneuropathies, this communication is disrupted, leading to various symptoms depending on the type and extent of nerve damage. Commonly reported symptoms include:
1. Numbness or tingling in the hands and feet
2. Muscle weakness and cramps
3. Loss of reflexes
4. Burning or stabbing pain
5. Balance and coordination issues
6. Increased sensitivity to touch
7. Autonomic dysfunction, such as bowel, bladder, or digestive problems, and changes in blood pressure
Polyneuropathies can be caused by various factors, including diabetes, alcohol abuse, nutritional deficiencies, autoimmune disorders, infections, toxins, inherited genetic conditions, or idiopathic (unknown) causes. The treatment for polyneuropathy depends on the underlying cause and may involve managing underlying medical conditions, physical therapy, pain management, and lifestyle modifications.
Paraproteinemias refer to the presence of abnormal levels of paraproteins in the blood. Paraproteins are immunoglobulins (antibodies) produced by plasma cells, which are a type of white blood cell found in the bone marrow. In healthy individuals, paraproteins play a role in the immune system's response to infection and disease. However, in certain conditions, such as multiple myeloma, monoclonal gammopathy of undetermined significance (MGUS), and Waldenstrom macroglobulinemia, plasma cells produce excessive amounts of a single type of paraprotein, leading to its accumulation in the blood.
Paraproteinemias can cause various symptoms depending on the level of paraproteins present and their impact on organs and tissues. These symptoms may include fatigue, weakness, numbness or tingling in the extremities, bone pain, recurrent infections, and kidney problems. In some cases, paraproteinemias may not cause any symptoms and may only be detected during routine blood tests.
It is important to note that while paraproteinemias are often associated with plasma cell disorders, they can also occur in other conditions such as chronic inflammation or autoimmune diseases. Therefore, further testing and evaluation are necessary to determine the underlying cause of paraproteinemia and develop an appropriate treatment plan.
Melphalan is an antineoplastic agent, specifically an alkylating agent. It is used in the treatment of multiple myeloma and other types of cancer. The medical definition of Melphalan is:
A nitrogen mustard derivative that is used as an alkylating agent in the treatment of cancer, particularly multiple myeloma and ovarian cancer. Melphalan works by forming covalent bonds with DNA, resulting in cross-linking of the double helix and inhibition of DNA replication and transcription. This ultimately leads to cell cycle arrest and apoptosis (programmed cell death) in rapidly dividing cells, such as cancer cells.
Melphalan is administered orally or intravenously, and its use is often accompanied by other anticancer therapies, such as radiation therapy or chemotherapy. Common side effects of Melphalan include nausea, vomiting, diarrhea, and bone marrow suppression, which can lead to anemia, neutropenia, and thrombocytopenia. Other potential side effects include hair loss, mucositis, and secondary malignancies.
It is important to note that Melphalan should be used under the close supervision of a healthcare professional, as it can cause serious adverse reactions if not administered correctly.
Paraneoplastic syndromes refer to a group of rare disorders that are caused by an abnormal immune system response to a cancerous (malignant) tumor. These syndromes are characterized by symptoms or signs that do not result directly from the growth of the tumor itself, but rather from substances produced by the tumor or the body's immune system in response to the tumor.
Paraneoplastic syndromes can affect various organs and systems in the body, including the nervous system, endocrine system, skin, and joints. Examples of paraneoplastic syndromes include Lambert-Eaton myasthenic syndrome (LEMS), which affects nerve function and causes muscle weakness; cerebellar degeneration, which can cause difficulty with coordination and balance; and dermatomyositis, which is an inflammatory condition that affects the skin and muscles.
Paraneoplastic syndromes can occur in association with a variety of different types of cancer, including lung cancer, breast cancer, ovarian cancer, and lymphoma. Treatment typically involves addressing the underlying cancer, as well as managing the symptoms of the paraneoplastic syndrome.
An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.
The endocrine system is a complex network of glands and organs that produce, store, and secrete hormones. It plays a crucial role in regulating various functions in the body, including metabolism, growth and development, tissue function, sexual function, reproduction, sleep, and mood.
Endocrine system diseases or disorders occur when there is a problem with the production or regulation of hormones. This can result from:
1. Overproduction or underproduction of hormones by the endocrine glands.
2. Impaired response of target cells to hormones.
3. Disruption in the feedback mechanisms that regulate hormone production.
Examples of endocrine system diseases include:
1. Diabetes Mellitus - a group of metabolic disorders characterized by high blood sugar levels due to insulin deficiency or resistance.
2. Hypothyroidism - underactive thyroid gland leading to slow metabolism, weight gain, fatigue, and depression.
3. Hyperthyroidism - overactive thyroid gland causing rapid heartbeat, anxiety, weight loss, and heat intolerance.
4. Cushing's Syndrome - excess cortisol production resulting in obesity, high blood pressure, and weak muscles.
5. Addison's Disease - insufficient adrenal hormone production leading to weakness, fatigue, and low blood pressure.
6. Acromegaly - overproduction of growth hormone after puberty causing enlargement of bones, organs, and soft tissues.
7. Gigantism - similar to acromegaly but occurs before puberty resulting in excessive height and body size.
8. Hypopituitarism - underactive pituitary gland leading to deficiencies in various hormones.
9. Hyperparathyroidism - overactivity of the parathyroid glands causing calcium imbalances and kidney stones.
10. Precocious Puberty - early onset of puberty due to premature activation of the pituitary gland.
Treatment for endocrine system diseases varies depending on the specific disorder and may involve medication, surgery, lifestyle changes, or a combination of these approaches.
POEMS syndrome
Vascular endothelial growth factor A
Plasma cell dyscrasias
List of autoimmune diseases
Michael A. Gorman
Deaths in November 2019
Cherry angioma
Castleman disease
Deaths in December 2012
Lisa Kindred
Glomeruloid hemangioma
Idiopathic multicentric Castleman disease
Lisa Thomas-Laury
Fever of unknown origin
Monoclonal gammopathy of undetermined significance
List of MeSH codes (C20)
Poetry (disambiguation)
Dominic Chad
List of MeSH codes (C16)
Papilledema
Hyperhidrosis
List of MeSH codes (C15)
San Clemente al Laterano
Resignation (disambiguation)
Paradise Syndrome
Revolution (The Dubliners album)
The Bronze Horseman (poem)
Lyubov Sirota
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Pripyat
POEMS syndrome - Wikipedia
POEMS Syndrome: Background, Pathophysiology, Etiology
POEMS syndrome | DermNet
Treatment of POEMS Syndrome With Daratumumab | Clinical Research Trial Listing ( POEMS Syndrome ) ( NCT04396496 )
Information for "POEMS syndrome causes" - wikidoc
Grandma Lee: A Poem by Spencer Ginyard - Prader-Willi Syndrome Association | USA
Big brother's poem to sister with Down syndrome melts hearts
Longitudinal bioimpedance assessments to evaluate hydration in POEMS syndrome - Lancaster EPrints
POEMS Syndrome - Hormonal and Metabolic Disorders - MSD Manual Consumer Version
Thyroid, Parathyroid, Adrenal, Endocrine Surgery, What is POEMS syndrome?
POEMS syndrome - wikidoc
POEMS Syndrome - Allied Medical Training
Monitoring of Vascular Endothelial Growth Factor in POEMS Syndrome
Polyneuropathy improvement following autologous stem cell transplantation for POEMS syndrome - Fingerprint - Mayo Clinic
How I treat POEMS syndrome. | Hospital Medicine Virtual Journal Club | Washington University in St. Louis
Soft Machine (Truman Syndrome) and Soft Machine (in Isolation). Two poems by Thomas Irvine - Pendemic poetry
THE WEEKLY INJECTION: New Releases From IGGY POP, NORTH, BORIS WITH MERZBOW and More Out Today - 3/18
Detection of Clonal Plasma Cells in POEMS Syndrome Using Multiparameter Flow Cytometry | Blood | American Society of Hematology
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Search - NeL.edu
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Polyneuropathy6
- The name POEMS is an acronym for some of the disease's major signs and symptoms (polyneuropathy, organomegaly, endocrinopathy, myeloma protein, and skin changes), as is PEP (polyneuropathy, endocrinopathy, plasma cell dyscrasia). (wikipedia.org)
- Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome is a rare multisystemic disease that occurs in the setting of a plasma cell dyscrasia. (medscape.com)
- The polyneuropathy associated with POEMS syndrome is a bilateral symmetric disturbance. (medscape.com)
- This trial investigates the use of Daratumumab (DARA), an antibody directed at the human cluster of differentiation 38 (CD38) molecule, for the treatment of patients with Polyneuropathy, Organomegaly, Endocrinopathy, m Protein Component, Skin Changes (POEMS) syndrome. (centerwatch.com)
- Polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes (POEMS) syndrome is a rare paraneoplastic disorder associated with an underlying plasma cell dyscrasia and multiorgan failure. (lancs.ac.uk)
- The initial presentation occasionally is a polyneuropathy when it is part of POEMS syndrome (mostly the sclerotic form). (radiopaedia.org)
Amyloidosis2
- Most of the patients in my clinic are blood and bone marrow transplant patients and patients with plasma cell diseases such as multiple myeloma, amyloidosis, POEMS syndrome, and Waldenstrom's macroglobulinemia. (dukehealth.org)
- Founded on the secretion of a monoclonal immunoglobulin (M-protein), plasma cell proliferative disorders are classified as monoclonal gammopathies and include multiple myeloma (MM), Waldenström's macroglobulinemia (WM), amyloidosis (AL), light chain deposition disease (LCDD), POEMS syndrome, and premalignant diseases such as monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM). (degruyter.com)
Endocrinopathy1
- POEMS syndrome is a paraneoplastic syndrome whose acronym stands for less than half of the defining features of the disease, that is polyradiculoneuropathy, organomegaly, potentially including co-existing Castleman's disease, endocrinopathy, monoclonal plasma cell neoplasm, and skin changes. (wustl.edu)
Termed Crow-Fukase s1
- The syndrome was termed Crow-Fukase syndrome (by which it is known in Japan) by Nakanishi in a study of 102 cases in Japan. (medscape.com)
Disorders4
- Although many plasma cell disorders have been reported in patients with POEMS syndrome, most patients are seen with osteosclerotic myeloma or monoclonal gammopathy of unknown significance. (medscape.com)
- Polyglandular Deficiency Syndromes Polyglandular deficiency syndromes are hereditary disorders in which several endocrine (hormone-producing) glands malfunction. (msdmanuals.com)
- The cause of POEMS isn't clear, and POEMS can be misdiagnosed since its signs and symptoms are similar to other disorders. (alliedmedtraining.com)
- A remarkable variety of endocrinologic disorders may cause virilization syndromes. (annals.edu.sg)
Myeloma4
- POEMS syndrome (also termed osteosclerotic myeloma, Crow-Fukase syndrome, Takatsuki disease, or PEP syndrome) is a rare paraneoplastic syndrome caused by a clone of aberrant plasma cells. (wikipedia.org)
- Many of the signs and symptoms in POEMS syndrome are due at least in part to the release of an aberrant immunoglobulin, i.e. a myeloma protein, as well as certain cytokines by the malignant plasma cells. (wikipedia.org)
- It is suggested that various other cytokines produced by the clonal plasma cells, perhaps working in concert with each other as well as with VEGF and the myeloma proteins, mediate many of the features of POEMS syndrome. (wikipedia.org)
- B cells, related to, and often associated with, primary nodal plasmacytoma and osteosclerotic myeloma (socalled POEMS, Takatsuki s or crow-fukase s syndrome). (geometry.net)
Paraneoplastic syndrome1
- Signs and symptoms of a cancer causing a paraneoplastic syndrome result from the release of humoral factors such as hormones, cytokines, or immunoglobulins by the syndrome's neoplastic cells and/or the response of the immune system to the neoplasm. (wikipedia.org)
Observed in patients with POEMS syndrome1
- Some features have been observed in patients with POEMS syndrome but are not yet certain to form part of the syndrome itself. (wikipedia.org)
Deficiency1
- Differential diagnoses include cryoglobulinemia, warfarin-induced necrosis, purpura fulminans, emboli to the skin, thrombocythemia, protein C deficiency, Sneddon syndrome, and skin ulcers in patients with sickle cell anemia or hemolytic anemia. (medscape.com)
Diagnosis5
- The diagnosis of POEMS syndrome is based on meeting its two mandatory criteria, meeting at least one of its 3 other major criteria, and meeting at least one of its 6 minor criteria. (wikipedia.org)
- Early diagnosis is key since POEMS can become life-threatening without treatment. (alliedmedtraining.com)
- The question is from Augusto Hasiak Santo:] The Brazilian Ministry of Health is preparing a manual on occupational diseases and a coding problem with the diagnosis hypothenar hammer syndrome occurs. (geometry.net)
- A diagnosis of restrictive allograft syndrome is made - how to deal with this patient? (ers-education.org)
- Diagnosis and pharmacotherapy of severe acute respiratory syndrome: what have we learnt? (ers-education.org)
Antiphospholipid Syndrome9
- Antiphospholipid syndrome (APS) is an acquired, multisystemic disorder characterized by recurrent thromboses in the arterial system, venous system, or both. (medscape.com)
- Antiphospholipid syndrome is classified into 2 groups: primary and secondary. (medscape.com)
- Serologic markers for antiphospholipid syndrome are antiphospholipid antibodies (beta2-GPI or anticardiolipins) or lupus anticoagulant. (medscape.com)
- In a large retrospective study from the Mayo Clinic, 41% of patients with lupus anticoagulant had skin lesions as the first sign of antiphospholipid syndrome. (medscape.com)
- Noninflammatory vascular thrombosis is the most frequent finding in skin lesions of patients with antiphospholipid syndrome. (medscape.com)
- In some antiphospholipid syndrome lesions, hemosiderin deposition can make differentiation from Kaposi sarcoma difficult. (medscape.com)
- The mainstays of prophylaxis and treatment of thrombosis in patients with antiphospholipid syndrome are anticoagulant and antiplatelet agents. (medscape.com)
- Some patients with antiphospholipid syndrome may have resistance to a usual dose of subcutaneous heparin. (medscape.com)
- Warfarin is the treatment of choice for patients with antiphospholipid syndrome. (medscape.com)
Acronym2
- In addition to the signs and symptoms indicated by the POEMS acronym, the PEST acronym is used to describe some of the other signs and symptoms of the disease. (wikipedia.org)
- The more common features of the disease are summarized in the acronym POEMS: Papilledema (swelling of the optic disc) often but not always due to increased intracranial pressure) is the most common ocular sign of POEMS syndrome, occurring in ≥29% of cases. (wikipedia.org)
Diseases3
- The other possible code is "I73.8 - Other specified peripheral vascular diseases", because the hypothenar hammer syndrome also occurs with peripheral vascular affections. (geometry.net)
- Asthma: a complex syndrome of many diseases? (ers-education.org)
- Source: International Congress 2014 - ME09 Asthma: a complex syndrome of many diseases? (ers-education.org)
Features of POEMS syndrome1
- What are the clinical features of POEMS syndrome? (dermnetnz.org)
Symptoms of POEMS syndrome1
- The signs and symptoms of POEMS syndrome are highly variable. (wikipedia.org)
Presentation of POEMS syndrome2
- Subacute, distal, symmetrical sensorimotor neuropathy with allodynia and hyperpathia is the most frequent presentation of POEMS syndrome. (wikipedia.org)
- A common initial presentation of POEMS syndrome is with progressive weakness and swelling of the peripheries. (dermnetnz.org)
Endocrine3
- Multiple endocrinopathies have been associated with POEMS syndrome, and most patients have more than 1 endocrine abnormality. (medscape.com)
- POEMS syndrome is a rare disorder in which more than one endocrine gland is dysfunctional. (msdmanuals.com)
- POEMS syndrome is probably caused by antibodies (immunoglobulins) that circulate in the blood and damage organs, particularly endocrine glands. (msdmanuals.com)
Atypical1
- However, the findings of a retrospective analysis of 629 patients using these criteria suggest that this approach may be inadequate for excluding other disease processes that may account for symptoms and that atypical presentations of POEMS may be misdiagnosed. (medscape.com)
Systemic2
- However, CAR-T cells can also produce some adverse events after treatment of hematological malignancies, such as cytokine release syndrome (CRS), neurotoxicity, and on-target/off-tumor toxicity, which may cause systemic immune stress inflammation, destruction of the blood-brain barrier, and even normal tissue damage. (hindawi.com)
- Indications for immunotherapy are limited to systemic lupus erythematous or catastrophic vascular occlusion syndrome. (medscape.com)
Monoclonal protein1
- [ 5 ] serum electrophoresis demonstrated an M-band with isolated IgA heavy chain but no abnormal light chain, which could suggest abnormal secretion of monoclonal protein or the rare possibility of coincidental heavy-chain disease in association with POEMS syndrome. (medscape.com)
Disease5
- Approximately 15% of patients with POEMS syndrome have concomitant evidence of Castleman disease, and both may be associated with glomeruloid hemangioma. (medscape.com)
- We present three case reports of patients with POEMS syndrome with different clinical manifestation and course of the disease. (benthamopen.com)
- POEMS syndrome, disease monitoring, VEGF. (benthamopen.com)
- Williams-Campbell syndrome: is an infantile rare disease with poor prognosis? (ers-education.org)
- Is widal syndrome usually a severe disease? (ers-education.org)
Disorder4
- The type of plasma cell disorder has not been shown to be correlated with the constellation of symptoms noted in patients with POEMS syndrome. (medscape.com)
- POEMS syndrome is a rare multisystem disorder. (dermnetnz.org)
- POEMS syndrome is a rare blood disorder suspected to affect up to 5000 people in the USA, primarily men who are in later adulthood (around age 50). (alliedmedtraining.com)
- POEMS SyndromeThe rare blood disorder named for its symptoms.By Jenny Ewen, BA, NREMTEditor-In-ChiefPOEMS syndrome is a rare blood disorder suspected to affect up to 5000 people in the USA, primarily men who are in later adulthood (around age 50). (alliedmedtraining.com)
Acute2
- It can be considered the chronic equivalent of acute inflammatory demyelinating polyradiculoneuropathy, the most common form of Guillain-Barré syndrome. (medscape.com)
- A resolution for acute respiratory distress syndrome? (ers-education.org)
Abnormalities1
- Lung abnormalities in marfan syndrome: a pathogenetic model of early-onset emphysema? (ers-education.org)
Children with Down Syndrome1
- Recurrent wheeze in children with Down syndrome: Is it asthma? (ers-education.org)
Patients4
- On iliac crest biopsies, patients with POEMS syndrome often have few monoclonal plasma cells. (wikipedia.org)
- however, most authors agree that patients with POEMS syndrome should have 3 or more of the 5 features. (medscape.com)
- Darkened skin colour ( hyperpigmentation ) has been seen in about 50-90% patients with POEMS syndrome. (dermnetnz.org)
- This trial investigates the use of DARA, an antibody directed at the human CD38 molecule, for the treatment of patients with POEMS syndrome. (centerwatch.com)
Plasma cells1
- This syndrome damages the nerves and organs due to an increased number of abnormal plasma cells with overproduction of proinflammatory molecules resulting in leaky capillaries leading to edema, effusions, nerve damage, pulmonary hypertension and an increase in WBCs and platelets. (alliedmedtraining.com)
VEGF3
- For example, VEGF, given its ability to stimulate blood vessel formation, would seem likely to be the major contributor to the pathologic hyper-vascularization changes seem in many tissues, such as lymph nodes, affected by POEMS syndrome. (wikipedia.org)
- We suggest the use of VEGF not only for the diagnostics but also as a potential marker of therapeutic response and for monitoring of the course of POEMS syndrome. (benthamopen.com)
- Elevated levels of VEGF is linked to POEMS syndrome, also known as Crow-Fukase syndrome. (prospecbio.com)
Chronic1
- With everything that we know today about chronic fatigue syndrome, and all the cautionary examples that exist, why do people still burn out? (lu.se)
Essential1
- There is no cure for POEMS, and treatment is essential. (alliedmedtraining.com)