Persistence of the nuclei of the keratinocytes into the stratum corneum of the skin. This is a normal state only in the epithelium of true mucous membranes in the mouth and vagina. (Dorland, 27th ed)
The quantity of volume or surface area of a CELL NUCLEUS.
The quality of surface form or outline of the CELL NUCLEUS.
Any inflammation of the skin.
A heritable disorder of faulty keratinization characterized by the proliferation of abnormal clones of KERATINOCYTES and lesions showing varying atrophic patches surrounded by an elevated, keratotic border. These keratotic lesions can progress to overt cutaneous neoplasm. Several clinical variants are recognized, including porokeratosis of Mibelli, linear porokeratosis, disseminated superficial actinic porokeratosis, palmoplantar porokeratosis, and punctate porokeratosis.
Any horny growth such as a wart or callus.
A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.
Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations.
The external, nonvascular layer of the skin. It is made up, from within outward, of five layers of EPITHELIUM: (1) basal layer (stratum basale epidermidis); (2) spinous layer (stratum spinosum epidermidis); (3) granular layer (stratum granulosum epidermidis); (4) clear layer (stratum lucidum epidermidis); and (5) horny layer (stratum corneum epidermidis).
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
A superficial dermatitis occurring on skin surfaces in contact with each other, such as the axillae, neck creases, intergluteal fold, between the toes, etc. Obesity is a predisposing factor. The condition is caused by moisture and friction and is characterized by erythema, maceration, burning, and exudation.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)

Impact of global genome repair versus transcription-coupled repair on ultraviolet carcinogenesis in hairless mice. (1/21)

The nucleotide excision repair (NER) system is comprised of two subpathways, i.e., transcription-coupled repair (TCR) and global genome repair (GGR). To establish the relative importance of TCR and GGR for UV effects on the skin, we have used hairless knockout mouse strain lacking either TCR (CSB -/-) or GGR (XPC -/-). In single exposure experiments, we found that CSB -/- mice have a 7-16 times higher susceptibility to sunburn than XPC -/- mice and than heterozygous (+/-) and wild-type (+/+) controls. Exposure to 80 J/m2 UV radiation (i.e., suberythemogenic in CSB -/-) on 10 consecutive days gives rise to epidermal hyperplasia in CSB -/- and XPC -/-, whereas repair-proficient controls do not show epidermal hyperplasia from these exposures. In addition, CSB -/- mice develop marked parakeratosis, whereas XPC -/- mice and controls do not. Under continued exposure to this daily dose, squamous cell carcinomas appear in CSB -/-, XPC -/-, and in the control groups, whereas only in the CSB -/- animals is a fairly high number of benign papillomas also found. The median latency time of squamous cell carcinomas (diameters > or = 1 mm) is 84 days for the XPC -/- mice, 115 days for the CSB -/- mice, and 234-238 days for the heterozygous and wild-type control groups. These results indicate that GGR is more important than TCR in protection against UV-induced carcinomas of the skin but not against other UV effects such as sunburn, epidermal thickening, scaling of the stratum corneum, and development of papillomas. These results also indicate that GGR capacity may serve as a better predictor for skin cancer susceptibility than sensitivity to sunburn. The relative cancer susceptibilities of GGR- and TCR-deficient skin could well depend on the balance between an increased mutation rate and the presence (in CSB -/-) or lack (in XPC -/-) of a compensatory apoptotic response.  (+info)

Axillary granular parakeratosis. (2/21)

A 71-year-old man developed a pruritic axillary eruption. Histopathologic examination showed laminated orthokeratosis, parakeratosis, and hypergranulosis. There changes were consistent with a diagnosis of axillary granular parakeratosis. Axillary granular parakeratosis is an intertriginous eruption that is usually found in the axillae of middle-aged women and is characterized clinically by pruritic, erythematous, hyperkeratotic plaques and histologically by parakeratosis with retention of keratohyaline granules. Pathophysiology is thought to involve a defective profilaggrin-filaggrin pathway. Evidence-based treatment of this disorder is not available.  (+info)

Granular parakeratosis presenting with facial keratotic papules. (3/21)

A 27-year-old female presented with pruritic keratotic papules over the left side of the face since one month. The lesions developed a few days after working in a hot humid environment and were preceded by severe uncontrollable pruritus for which she had repeatedly wiped the area with handkerchiefs and towels. A biopsy from one of the keratotic papules revealed granular parakeratosis with a markedly thick stratum corneum that had parakeratosis and also housed keratohyaline granules. Similar changes were seen in keratotic plugs of dilated follicular infundibula.  (+info)

Reiter's syndrome in a patient with polyarthritis and nail involvement. (4/21)

 (+info)

Ruminal acidosis and the rapid onset of ruminal parakeratosis in a mature dairy cow: a case report. (5/21)

 (+info)

Irritated seborrheic keratosis with coarse keratohyalin granules. (6/21)

AIMS: The viral etiology of certain types of seborrheic keratosis (SK) has been a controversial subject in literature, with different molecular results. On the contrary, to the molecular approach, some have suggested that certain types of SK are indeed warts, due to their morphologic features. We decided to investigate the presence of coarse keratohyalin granules in cases of irritated SK. MATERIAL, METHODS AND RESULTS: We examined the last 60 cases with such a diagnosis in our Service of Anatomic Pathology and found these granules in eight cases (7.5%). The granules were evidenced in squamous eddies in four cases, while they were seen in foci of hypergranulosis from the top part of the epidermis in five cases. These granules were evidenced in a few foci in three cases while they were seen in multiple foci in five cases. In these eight cases, we also looked for other morphologic signs suggesting a viral origin, such as papilated, exo-endophytic configuration, parakeratosis at the tips of digitations, dilated vessels in the papillae and koilocytes. While six cases presented at least any of these other features, in two of the eight cases (25%), the only clue suggesting a viral origin was the evidence of the thick granules of keratohyalin. CONCLUSIONS: We discuss the meaning of such a finding as described in literature, and conclude that it should be a specific feature to look out for, in cases of irritated SK, in order to exclude a diagnosis of verruca vulgaris.  (+info)

Punctate porokeratotic keratoderma. (7/21)

We report a 29-year-old woman with multiple small keratotic papules on her lateral fingers and first and second toes. Histopathology revealed a compact parakeratotic column with a poorly developed stratum granulosum, indicating punctate porokeratotic keratoderma (PPK). We discuss demographics, etiology, histopathology, differential diagnosis, and treatment of this disease.  (+info)

Benign versus malignant parakeratosis: a nuclear morphometry study. (8/21)

 (+info)

Parakeratosis is a medical term that refers to a skin condition where the outermost layer of the skin (the stratum corneum) contains nucleated keratinocytes, which are cells that have not fully matured and still contain their nuclei. This is in contrast to normal stratum corneum, which consists of flat, dead keratinocytes without nuclei.

Parakeratosis can occur in various skin disorders, such as psoriasis, eczema, warts, and certain types of dermatitis. It can also be seen in some benign or malignant skin tumors. The presence of parakeratosis may indicate abnormal differentiation or proliferation of the skin cells, which can contribute to the development of skin lesions or diseases.

In addition to its role in skin disorders, parakeratosis has been implicated in the pathogenesis of certain gastrointestinal diseases, such as Barrett's esophagus and colon cancer, where it is associated with abnormal cell growth and increased risk of malignancy.

The cell nucleus is a membrane-bound organelle found in the eukaryotic cells (cells with a true nucleus) that contains most of the cell's genetic material. The term "cell nucleus size" refers to the volume or diameter of this organelle. It can vary depending on the type and stage of the cell.

In general, the size of a nucleus is expressed as a ratio to the size of the cell, known as the nuclear-to-cytoplasmic ratio (N/C ratio). This ratio can provide important clues about the state and function of a cell. For example, cancerous cells often have larger nuclei and higher N/C ratios compared to normal cells.

It's worth noting that measuring the size of a nucleus can be challenging, as it is not always uniform in shape or easily distinguishable from other structures within the cell. Various techniques, such as microscopy and image analysis software, are used to accurately determine the dimensions of the nucleus.

The cell nucleus is a membrane-bound organelle that contains most of the genetic material in eukaryotic cells. The shape of the cell nucleus can vary widely among different cell types and can be influenced by various factors, including the organization of the nuclear envelope, the distribution of chromatin (the complex of DNA, RNA, and proteins that makes up chromosomes), and the presence or absence of a nucleolus (a structure within the nucleus where ribosomal RNA is synthesized).

The shape of the cell nucleus can be described in several ways, including:

* Spherical: The nucleus has a round, ball-like shape.
* Ellipsoidal: The nucleus has an oval or ellipse-like shape.
* Irregular: The nucleus has a shape that is not easily described as spherical or ellipsoidal and may be lobed, indented, or have other irregularities.

The shape of the cell nucleus can provide important clues about the function and health of a cell. For example, certain diseases and conditions, such as cancer, can cause changes in the shape of the nucleus. In addition, some researchers have suggested that the shape of the nucleus may be related to the mechanical properties of the cell and its ability to migrate or change shape in response to its environment.

Dermatitis is a general term that describes inflammation of the skin. It is often characterized by redness, swelling, itching, and tenderness. There are many different types of dermatitis, including atopic dermatitis (eczema), contact dermatitis, seborrheic dermatitis, and nummular dermatitis.

Atopic dermatitis is a chronic skin condition that often affects people with a family history of allergies, such as asthma or hay fever. It typically causes dry, scaly patches on the skin that can be extremely itchy.

Contact dermatitis occurs when the skin comes into contact with an irritant or allergen, such as poison ivy or certain chemicals. This type of dermatitis can cause redness, swelling, and blistering.

Seborrheic dermatitis is a common condition that causes a red, itchy rash, often on the scalp, face, or other areas of the body where oil glands are located. It is thought to be related to an overproduction of oil by the skin's sebaceous glands.

Nummular dermatitis is a type of eczema that causes round, coin-shaped patches of dry, scaly skin. It is more common in older adults and often occurs during the winter months.

Treatment for dermatitis depends on the underlying cause and severity of the condition. In some cases, over-the-counter creams or lotions may be sufficient to relieve symptoms. Prescription medications, such as corticosteroids or immunosuppressants, may be necessary in more severe cases. Avoiding triggers and irritants can also help prevent flare-ups of dermatitis.

Porokeratosis is a skin condition characterized by the development of benign, progressive, and persistent papules or plaques with a ridge-like border called "cornoid lamella." These lesions can appear anywhere on the body but are most commonly found on sun-exposed areas. The condition results from abnormal keratinization and can be inherited or acquired. There are several types of porokeratosis, including porokeratosis of Mibelli, disseminated superficial actinic porokeratosis, punctate porokeratosis, linear porokeratosis, and porokeratosis palmaris et plantaris disseminata. The exact cause is unknown, but genetic mutations, ultraviolet (UV) radiation exposure, immunosuppression, and human papillomavirus (HPV) infection have been implicated in its development. Treatment options include topical therapies, cryotherapy, laser surgery, and photodynamic therapy.

Keratosis, in general, refers to a skin condition characterized by the abnormal growth or development of keratin, a protein that forms part of the outer layer of the skin (epidermis). There are several types of keratosis, including:

1. Seborrheic Keratosis: benign, often pigmented, rough, and scaly growths that can appear anywhere on the body. They tend to increase in number with age.
2. Actinic Keratosis: rough, scaly patches or spots on the skin that are caused by long-term exposure to sunlight or artificial UV light. These have the potential to develop into squamous cell carcinoma, a type of skin cancer.
3. Solar Keratosis: another term for actinic keratosis, as it is primarily caused by sun damage.
4. Keratosis Pilaris: a common condition where small, rough bumps appear on the skin, often on the arms, thighs, or cheeks. These are caused by excess keratin blocking hair follicles.
5. Follicular Keratosis: a disorder characterized by the formation of horny plugs within the hair follicles, leading to rough, sandpaper-like bumps on the skin.
6. Intraepidermal Keratosis: a term used to describe the abnormal accumulation of keratin in the epidermis, which can lead to various skin conditions.

It's important to consult with a healthcare professional or dermatologist for proper diagnosis and treatment if you suspect having any form of keratosis.

Psoriasis is a chronic skin disorder that is characterized by recurrent episodes of red, scaly patches on the skin. The scales are typically silvery-white and often occur on the elbows, knees, scalp, and lower back, but they can appear anywhere on the body. The exact cause of psoriasis is unknown, but it is believed to be related to an immune system issue that causes skin cells to grow too quickly.

There are several types of psoriasis, including plaque psoriasis (the most common form), guttate psoriasis, inverse psoriasis, pustular psoriasis, and erythrodermic psoriasis. The symptoms and severity of the condition can vary widely from person to person, ranging from mild to severe.

While there is no cure for psoriasis, various treatments are available that can help manage the symptoms and improve quality of life. These may include topical medications, light therapy, and systemic medications such as biologics. Lifestyle measures such as stress reduction, quitting smoking, and avoiding triggers (such as certain foods or alcohol) may also be helpful in managing psoriasis.

The mouth mucosa refers to the mucous membrane that lines the inside of the mouth, also known as the oral mucosa. It covers the tongue, gums, inner cheeks, palate, and floor of the mouth. This moist tissue is made up of epithelial cells, connective tissue, blood vessels, and nerve endings. Its functions include protecting the underlying tissues from physical trauma, chemical irritation, and microbial infections; aiding in food digestion by producing enzymes; and providing sensory information about taste, temperature, and texture.

The epidermis is the outermost layer of the skin, composed mainly of stratified squamous epithelium. It forms a protective barrier that prevents water loss and inhibits the entry of microorganisms. The epidermis contains no blood vessels, and its cells are nourished by diffusion from the underlying dermis. The bottom-most layer of the epidermis, called the stratum basale, is responsible for generating new skin cells that eventually move up to replace dead cells on the surface. This process of cell turnover takes about 28 days in adults.

The most superficial part of the epidermis consists of dead cells called squames, which are constantly shed and replaced. The exact rate at which this happens varies depending on location; for example, it's faster on the palms and soles than elsewhere. Melanocytes, the pigment-producing cells, are also located in the epidermis, specifically within the stratum basale layer.

In summary, the epidermis is a vital part of our integumentary system, providing not only physical protection but also playing a crucial role in immunity and sensory perception through touch receptors called Pacinian corpuscles.

In medical terms, the skin is the largest organ of the human body. It consists of two main layers: the epidermis (outer layer) and dermis (inner layer), as well as accessory structures like hair follicles, sweat glands, and oil glands. The skin plays a crucial role in protecting us from external factors such as bacteria, viruses, and environmental hazards, while also regulating body temperature and enabling the sense of touch.

Intertrigo is a skin condition that occurs in warm, moist areas of the body where skin rubs together or overlaps, such as the groin, armpits, beneath the breasts, and between folds of fatty tissue. It is characterized by red, raw, itchy, or painful skin that may ooze or become scaly. Intertrigo can be caused by fungal or bacterial infections, excessive sweating, friction, or poor hygiene. Treatment typically involves keeping the affected area dry and exposed to air, using antifungal or antibacterial medications, and maintaining good personal hygiene.

An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.

... is seen in the plaques of psoriasis and in dandruff. Granular parakeratosis (originally termed axillary granular ... Parakeratosis is associated with the thinning or loss of the granular layer and is usually seen in diseases of increased cell ... In mucous membranes, parakeratosis is normal. In the skin, this process leads to the abnormal replacement of annular squames ... Parakeratosis is a mode of keratinization characterized by the retention of nuclei in the stratum corneum. ...
In dermatology, granular parakeratosis (also known as axillary granular parakeratosis, intertriginous granular parakeratosis, ...
... is a cutaneous condition which is exclusively seen in children, usually involving one finger, most ...
... is hyperkeratosis without parakeratosis. No nucleus is seen in the cells. There is also formation of an anuclear ...
Usually there is hyperplastic and acanthotic epithelium with parakeratosis. There is an inflammatory cell infiltrate and hyphae ...
A "flag sign" is often described, referring to alternating areas of orthokeratosis and parakeratosis. Epidermal thickening and ... It is hypothesized that the "rosette sign" corresponds histologically to the changes of orthokeratosis and parakeratosis known ... often with evident parakeratosis. Keratinocytes in the stratum malphigii may show a loss of polarity, pleomorphism, and ...
Histopathology, showing an ulceration surrounded by acanthosis and parakeratosis, with absence of atypia. List of cutaneous ...
Besides parakeratosis, air that is trapped between the cells may also cause this appearance. It is also caused by trauma. In ...
... and parakeratosis. Usually:A superficial perivascular inflammatory infiltrate Often: Thinning of epidermal cells overlying the ...
Granular Parakeratosis, though mostly an ailment of the armpit area, is also found on the cleavage. Most women have an increase ...
... along with marked parakeratosis. Bowen's disease is essentially equivalent to and used interchangeably with cSCC in situ, when ... will show hyperkeratosis and parakeratosis. There will also be marked acanthosis with elongation and thickening of the rete ...
... hyperkeratosis and parakeratosis, and keloids.[citation needed] Hypersensitive reactions to tattoos are known to lay latent for ...
... parakeratosis, or eosinophilic inclusions suggestive of viral warts. The sudden quality of the eruption of florid cutaneous ...
... and foci of parakeratosis. A lichenoid pattern with eosinophils' presence on biopsy of skin lesions has been observed in some ...
Biopsy and histopathological examination can be used to test for the presence of hyperkeratosis, parakeratosis, follicular ...
Common histologic findings of oral LP include: Parakeratosis and slight acanthosis of the epithelium Saw-toothed rete ridges ...
... parakeratosis and intracellular edema of the spinous layer. The cells of the spinous layer are vacuolated, large and possess ...
Florid cutaneous papillomatosis Granular parakeratosis (axillary granular parakeratosis, intertriginous granular parakeratosis ... Parakeratosis pustulosa Patterned acquired hypertrichosis Perforating folliculitis Pili annulati (ringed hair) Pili bifurcati ...
... epidermal necrosis subcorneal pustules confluent parakeratosis, epidermal hyperplasia, and marked papillary dermal hyperplasia ...
Poikiloderma Hyperkeratosis Parakeratosis Hypergranulosis Acanthosis Papillomatosis Dyskeratosis Acantholysis Spongiosis ...
... or para-keratosis, (depending upon whether cell nuclei are lost or retained in the superficial layers respectively), or a ...
... parakeratosis MeSH C17.800.428.750 - porokeratosis MeSH C17.800.480.479 - lupus erythematosus, discoid MeSH C17.800.480.479.400 ...
Parakeratosis is seen in the plaques of psoriasis and in dandruff. Granular parakeratosis (originally termed axillary granular ... Parakeratosis is associated with the thinning or loss of the granular layer and is usually seen in diseases of increased cell ... In mucous membranes, parakeratosis is normal. In the skin, this process leads to the abnormal replacement of annular squames ... Parakeratosis is a mode of keratinization characterized by the retention of nuclei in the stratum corneum. ...
Granular parakeratosis, a benign condition, was first described in 1991 as a skin disease manifesting with erythematous ... 5] Some suggest that granular parakeratosis has congenital links, [6] and others have considered if granular parakeratosis is a ... Scheinfeld NS, Mones J. Granular parakeratosis: pathologic and clinical correlation of 18 cases of granular parakeratosis. J Am ... No racial association has been reported for granular parakeratosis. Granular parakeratosis has been reported in blacks and ...
Learn more about Parakeratosis from related diseases, pathways, genes and PTMs with the Novus Bioinformatics Tool. ... Submit your video on Parakeratosis to be featured!. Submit a Video. Charities. Submit your charity on Parakeratosis to be ... Parakeratosis: Disease Bioinformatics. Research of Parakeratosis has been linked to Hyperkeratosis, Keratosis, Hyperplasia, ... Explore more on Parakeratosis below! For more information on how to use Laverne, please read the How to Guide.. ...
Autosomal recessive congenital ichthyosis (ARCI) is a heterogeneous group of disorders of keratinization characterized primarily by abnormal skin scaling over the whole body. These disorders are limited to skin, with approximately two-thirds of patients presenting severe symptoms. The main skin phenotypes are lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE), although phenotypic overlap within the same patient or among patients from the same family can occur (summary by Fischer, 2009). Neither histopathologic findings nor ultrastructural features clearly distinguish between NCIE and LI. In addition, mutations in several genes have been shown to cause both lamellar and nonbullous ichthyosiform erythrodermal phenotypes (Akiyama et al., 2003). At the First Ichthyosis Consensus Conference in Soreze in 2009, the term autosomal recessive congenital ichthyosis (ARCI) was designated to encompass LI, NCIE, and harlequin ichthyosis (ARCI4B; 242500) (Oji et al., 2010). ...
Granular parakeratosis. Multiple miliary osteoma cutis. Alopecia areata. Nevus sebaceous. Acanthosis nigricans. ...
Key differences included parakeratosis (P , or = 0.01), psoriasiform hyperplasia (P , or = 0.04) and spongiosis (P , or = 0.04 ...
Axillary granular parakeratosis. J Cutan Med Surg. 2003 Jul-Aug. 7 (4):330-2. [QxMD MEDLINE Link]. ...
Case of Parakeratosis in Piglets (Przypadek Parakeratozy u Prosiat).. 1972. 47. Changes in Nucleic Acids over the Molt Cycle in ...
B) The epidermis shows parakeratosis, atrophy, and a single apoptotic keratinocyte. An inflammatory infiltrate is present in ... B) The epidermis shows parakeratosis, atrophy, and a single apoptotic keratinocyte. An inflammatory infiltrate is present in ...
parakeratosis psoriasiformis 696.2. *. parapsoriasis 696.2. *Dermatitis (allergic) (contact) (occupational) (venenata) 692.9. * ...
1) Hyperkeratosis & parakeratosis. (2) Neutrophils in the epidermis. (3) Thinning of the epidermis overlying the dermal ...
b) Epidermal regular psoriasiform hyperplasia in the epidermis and parakeratosis with Munros microabscesses. (c) Chemical ...
The histological changes consisted of parakeratosis and occasional intra-epidermal pustules. A delayed skin-irritant action of ...
Hereditary Nasal Parakeratosis (Discovered in the Greyhound) Hereditary nasal parakeratosis (HNPK) is a disorder causing ... Hereditary Nasal Parakeratosis (Discovered in the Labrador Retriever) Hereditary nasal parakeratosis (HNPK) is a disorder ...
The rete ridges do not exhibit the characteristic pronounced sawtooth pattern because normal oral mucosa exhibits parakeratosis ... It is histopathologically differentiated from linear LP by exhibiting more prominent parakeratosis and spongiosis [115]. ... Lichenoid drug reactions characteristically exhibit parakeratosis, a dermal eosinophilic infiltrate, and a perivascular ... parakeratosis, hypergranulosis, papillomatosis, acanthosis, and hyperplasia markedly increased with thicker collagen bundles ...
Another common sign of zinc deficiency is parakeratosis. Scabs and white patches of hair appear on the flanks of zinc-deficient ...
Focal areas of spongiosis and parakeratosis.. What is the differential diagnosis of acanthoma fissuratum?. Acanthoma fissuratum ...
Condyloma acuminata may exhibit acanthosis, vacuolated keratinocytes, a more compact stratum corneum, and parakeratosis. ...
There is psoriasiform epidermal hyperplasia with spongiosis and mounds of parakeratosis. There is a superficial, perivascular ...
A skin biopsy showed hyperkeratosis, acanthosis and parakeratosis. Elongated rete ridges with keratinocyte hyperplasia, forming ...
Skin biopsy shows the same histological features as necrolytic migratory erythema: hyperkeratosis with parakeratosis, epidermal ...
... the stratified squamous epithelium of the esophagus was thickened with parakeratosis in pathological section observation. No ... the stratified squamous epithelium of the esophagus was thickened with parakeratosis in pathological section observation. No ...
A mutation in the SUV39H2 gene in Labrador Retrievers with hereditary nasal parakeratosis (HNPK) provides insights into the ...
... parakeratosis; study; expression; dermatitis; superfan; linkage; author; curriculum; Enroll; plan; stimulus; bed-time; tech; ...
A mild inflammatory reaction and parakeratosis can be present in the surrounding tissue. Direct immunofluorescence staining for ...
Histologically associated with parakeratosis, epithelial hyperplasia, focal acanthosis,. fusion, and elongated rete ridges. ...
Hyperkeratotic epidermis with acanthosis and parakeratosis. Rete ridges are elongated and irregular with a dense dermal ...
Note that goats are more susceptible to zinc deficiency (parakeratosis), but it may also occur in sheep. ...
  • Histopathological examination from the abdominal skin showed hyperkeratosis, parakeratosis, and acanthosis of the epidermis, with a scattered dermal inflammatory infiltrate and dilated lymphatic spaces in the papillary and reticular dermis. (cdlib.org)
  • Verruca vulgaris - church spire-like projections, hyperkeratosis and parakeratosis. (librepathology.org)
  • and Helios St. acanthosis, parakeratosis, and numerous koilocytes. (cdc.gov)
  • Hyperkeratotic epidermis with acanthosis and parakeratosis. (dermpathdiagnostics.com)
  • B) The epidermis shows parakeratosis, atrophy, and a single apoptotic keratinocyte. (cdc.gov)
  • b) Epidermal regular psoriasiform hyperplasia in the epidermis and parakeratosis with Munro's microabscesses. (hindawi.com)
  • There is psoriasiform epidermal hyperplasia with spongiosis and mounds of parakeratosis. (cdlib.org)
  • Histopathological analysis found proliferative epithelial activity with evident papillomatosis, parakeratosis, and large epithelial ridges. (bvsalud.org)
  • The sections show a squamous mucosa with a layer of compact keratin, parakeratosis, and focal hypergranulosis. (librepathology.org)
  • New cases of granular parakeratosis continue to be reported involving different body regions. (medscape.com)
  • Parakeratosis is associated with the thinning or loss of the granular layer and is usually seen in diseases of increased cell turnover, whether inflammatory or neoplastic. (wikipedia.org)
  • Granular parakeratosis (originally termed axillary granular parakeratosis) is an idiopathic, benign, nondisabling cutaneous disease that manifests with intertriginous erythematous, brown or red, scaly or keratotic papules and plaques. (wikipedia.org)
  • Granular parakeratosis, a benign condition, was first described in 1991 as a skin disease manifesting with erythematous hyperpigmented and hyperkeratotic papules and plaques of the cutaneous folds. (medscape.com)
  • [ 1 ] Granular parakeratosis has been associated with excessive use of topical preparations, in particular antiperspirants and deodorants, as well as exposure to chemical irritants found in antiseptics and household cleaning agents. (medscape.com)
  • This association is strongly supported by a case in which eradication of an occlusive environment resolved granular parakeratosis lesions. (medscape.com)
  • [ 6 ] and others have considered if granular parakeratosis is a disease or a reactive process. (medscape.com)
  • Granular parakeratosis in an 82-year-old man who developed this yellowish, scaly plaque at his left infra-axillary area after changing deodorants. (medscape.com)
  • Pathology confirmed granular parakeratosis. (medscape.com)
  • Because granular parakeratosis has been associated with excessive use of topical preparations, an occlusive environment, increased sweating, and, sometimes, local irritation, some suggest that it is an allergic contact or irritant reaction . (medscape.com)
  • [ 10 ] Some patients who have manifested granular parakeratosis have not used topical preparations, and, thus, the causal linkage of granular parakeratosis to topical substances is unclear. (medscape.com)
  • An interesting finding that mice that are deficient in caspase-14, an important protease necessary for the proper formation of a totally functional skin barrier, are more likely to develop parakeratosis may help elucidate the etiology of granular parakeratosis. (medscape.com)
  • [ 11 ] Furthermore, a mouse model study demonstrated that exposure to aluminium chloride, a main active ingredient commonly used in antiperspirants, induced the development of histologically confirmed granular parakeratosis on mouse skin. (medscape.com)
  • In any case, the primary cause for granular parakeratosis remains unknown. (medscape.com)
  • The cause of granular parakeratosis is uncertain. (medscape.com)
  • In one case, a patient developed granular parakeratosis after treatment with triamcinolone for contact dermatitis. (medscape.com)
  • An occlusive environment demonstrated to play an important role in a woman with submammary granular parakeratosis whose lesions resolved with mastopexy, thereby eradicating a warm, moist, friction-prone region. (medscape.com)
  • Several authors have postulated that in granular parakeratosis, a basic defect exists in the processing of profilaggrin to filaggrin. (medscape.com)
  • Only approximately 40 case reports of granular parakeratosis have been published, but it is likely more common than the number of case reports suggests. (medscape.com)
  • A punch biopsy (4 mm) of the right flank showed subacute spongiotic dermatitis with confluent parakeratosis and a perivascular infiltrate with lymphocytes and eosinophils, consistent with the diagnosis of superficial erythema annulare centrifugum. (cmaj.ca)
  • Parakeratosis is a mode of keratinization characterized by the retention of nuclei in the stratum corneum. (wikipedia.org)
  • Parakeratosis is seen in the plaques of psoriasis and in dandruff. (wikipedia.org)
  • Proposed nomenclature divides parapsoriasis into two distinct subgroups, PITYRIASIS LICHENOIDES and parapsoriasis en plaques (small- and large-plaque parapsoriasis). (wakehealth.edu)
  • A long series of diseases are already known to result from zinc deficiency of which parakeratosis (in swine) was first to be recognized (1,28). (medicaljournal-ias.org)
  • These pathways complement our catalog of research reagents for the study of Parakeratosis including antibodies and ELISA kits against FLG, IVL, KRT10, CD3, KRT14. (novusbio.com)
  • We have 4213 products for the study of Parakeratosis that can be applied to Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits. (novusbio.com)
  • Granular parakeratosis (originally termed axillary granular parakeratosis) is an idiopathic, benign, nondisabling cutaneous disease that manifests with intertriginous erythematous, brown or red, scaly or keratotic papules and plaques. (wikipedia.org)
  • Robinson AJ, Foster RS, Halbert AR, King E, Orchard D. Granular parakeratosis induced by benzalkonium chloride exposure from laundry rinse aids. (medscape.com)
  • Shen S, Pham CT, Ryan A, Bruce F. Granular parakeratosis in an adult female secondary to exposure to benzalkonium chloride laundry rinse. (medscape.com)
  • Submammary Granular Parakeratosis Treated With Mastopexy. (medscape.com)
  • Leclerc-Mercier S, Prost-Squarcioni C, Hamel-Teillac D, Fraitag S. A case of congenital granular parakeratosis. (medscape.com)
  • Martorell A, Sanmartín O, Hueso-Gabriel L, Guillén C. [Granular parakeratosis: disease or reactive response? (medscape.com)
  • Metze D, Rutten A. Granular parakeratosis - a unique acquired disorder of keratinization. (medscape.com)
  • Wallace CA, Pichardo RO, Yosipovitch G, Hancox J, Sangueza OP. Granular parakeratosis: a case report and literature review. (medscape.com)
  • Fujii M, Kishibe M, Honma M, Anan T, Ishida-Yamamoto A. Aluminum Chloride-Induced Apoptosis Leads to Keratinization Arrest and Granular Parakeratosis. (medscape.com)
  • Granular parakeratosis: four paediatric cases. (medscape.com)
  • Woodring T, Berryman S, Bradley L, Kentosh J. Granular parakeratosis associated with topical triamcinolone: Case report and literature review [abstract 147]. (medscape.com)
  • Braun-Falco M, Laaff H. Granular parakeratosis--a clinical-pathological correlation of 10 cases. (medscape.com)
  • Flora A, Whitfeld M. An interesting case of concurrent inguinal granular parakeratosis and red scrotum syndrome [abstract 73]. (medscape.com)
  • Available at https://dermcollabstracts.com/abstract/an-interesting-case-of-concurrent-inguinal-granular-parakeratosis-and-red-scrotum-syndrome . (medscape.com)
  • Demitsu T, Nakamura S, Takazawa M, Kakurai M, Umemoto N, Kawase M. Axillary granular parakeratosis with osmidrosis successfully treated with topical maxacalcitol. (medscape.com)
  • Trowers AB, Assaf R, Jaworsky C. Granular parakeratosis in a child. (medscape.com)
  • Granular parakeratosis is an itchy skin condition that affects the folds of the skin. (freedomfromglasses.org)
  • What are the signs of granular parakeratosis? (freedomfromglasses.org)
  • If you have granular parakeratosis, you'll see hyperkeratotic (thickened) lesions on your skin folds. (freedomfromglasses.org)
  • Parakeratosis is associated with the thinning or loss of the granular layer and is usually seen in diseases of increased cell turnover, whether inflammatory or neoplastic. (wikipedia.org)
  • Confocal features included parakeratosis, spongiosis, perivascular inflammatory infiltrate, and microvesicle formation, and these features were confirmed by routine histology. (cdc.gov)
  • Histologically, AKs have been classified ac cording to keratinocyte atypia, nuclear pleomorphism, hyperkeratosis, parakeratosis, a dermal inflammatory infiltrate and concomitant solar elastosis (6). (medicaljournals.se)
  • Dose selection rationale: Dose levels were selected based on results obtained from preliminary studies where it was shown that the test material elicited erythema and desquamation, epidermal thickening hyperkeratosis and/or localised parakeratosis when applied to rats at a dose level of 1000 mg/kg bw/day. (europa.eu)
  • 1. Histopathologic correlation of atypical parakeratosis diagnosed on cervicovaginal cytology. (nih.gov)
  • Parakeratosis pustulosa (PP) is a cause of distal nail inflammation and nail dystrophy that affects a single digit. (medscape.com)
  • Changes in parakeratosis, inflammation and dermal collagen remodelling were also observed. (medicaljournals.se)
  • A few minute foci of parakeratosis were present (Figure 2 ). (hindawi.com)