Parvoviridae
Parvovirus
Densovirus
Parvovirinae
Erythrovirus
Bocavirus
Circoviridae
Sequence Analysis, DNA
Molecular Sequence Data
Intranasal delivery of recombinant parvovirus-like particles elicits cytotoxic T-cell and neutralizing antibody responses. (1/736)
We previously demonstrated that chimeric porcine parvovirus-like particles (PPV:VLP) carrying heterologous epitopes, when injected intraperitoneally into mice without adjuvant, activate strong CD4(+) and CD8(+) T-cell responses specific for the foreign epitopes. In the present study, we investigated the immunogenicity of PPV:VLP carrying a CD8(+) T-cell epitope from the lymphocytic choriomeningitis virus (LCMV) administered by mucosal routes. Mice immunized intranasally with recombinant PPV:VLP, in the absence of adjuvant, developed high levels of PPV-specific immunoglobulin G (IgG) and/or IgA in their serum, as well as in mucosal sites such as the bronchoalveolar and intestinal fluids. Antibodies in sera from mice immunized parenterally or intranasally with PPV:VLP were strongly neutralizing in vitro. Intranasal immunization with PPV:VLP carrying the LCMV CD8(+) T-cell epitope also elicited a strong peptide-specific cytotoxic-T-cell (CTL) response. In contrast, mice orally immunized with recombinant PPV:VLP did not develop any antibody or CTL responses. We also showed that mice primed with PPV:VLP are still able to develop strong CTL responses after subsequent immunization with chimeric PPV:VLP carrying a foreign CD8(+) T-cell epitope. These results highlight the attractive potential of PPV:VLP as a safe, nonreplicating antigen carrier to stimulate systemic and mucosal immunity after nasal administration. (+info)Intrauterine management of fetal parvovirus B19 infection. (2/736)
OBJECTIVES: The aim of our study was to determine the outcome of pregnancies after intrauterine management of fetal parvovirus B19 infection. DESIGN: Retrospective study. SUBJECTS: A total of 37 cases of maternofetal parvovirus B19 infection, 35 of which were associated with hydrops fetalis, were referred to our tertiary level center between 1989 and 1996. With regard to fetal hydrops, no apparent cause other than parvovirus B19 infection was found in any patient. METHODS: In all patients, cordocentesis was performed to assess the degree of fetal anemia. When anemia was present, cordocentesis was followed by intrauterine transfusion with packed red cells into the umbilical vein. Further management depended on the degree of fetal anemia and gestational age and included follow-up fetal blood sampling/transfusion as well as ultrasound examinations as deemed appropriate. RESULTS: Packed red cell transfusion was performed in 30 patients with significant fetal anemia (Z-score 1.6-7.8 below the mean for gestational age). The fetal hemoglobin values ranged from 2.1 to 9.6 g/dl. Serum levels of platelets in the transfusion group were 9-228 x 10(9)/l with Z-scores in the range of < 1 to 3.8 below the mean. During treatment and follow-up, there were five intrauterine deaths (13.5%), one neonatal death (2.7%) and 31 live births (83.8%). CONCLUSIONS: Fetal parvovirus infection can lead to marked anemia and hydrops formation. Cordocentesis allows precise assessment of fetal anemia which can then be corrected by intravenous transfusion. Under this regimen, the outcome proved favorable in the majority of fetuses, even those that were severely anemic. (+info)Genetic heterogeneity of the immunogenic viral capsid protein region of human parvovirus B19 isolates obtained from an outbreak in a pediatric ward. (3/736)
Whereas human parvovirus B19 commonly infects children and causes erythema infectiosum, it causes more severe diseases when it infects adults. In order to examine whether different clinical outcomes of B19 infection can be ascribed to the viral genetic heterogeneity, we have determined the nucleotide sequence of highly immunogenic portions of the B19 genome obtained from six patients with various clinical manifestations in a single outbreak. Our observations demonstrated that although the B19 sequences showed a significant heterogeneity, it was not correlated with the clinical manifestation. It was thus suggested that the host immune response to B19 infection may be a major determinant of clinical presentations associated with acute B19 infection. (+info)Prenatal diagnosis of parvovirus B19-induced hydrops fetalis by chemiluminescence in situ hybridization. (4/736)
Parvovirus B19 can be transmitted transplacentally from the infected mother to the fetus during pregnancy, and hydrops fetalis, abortion, or stillbirth can result. In our study we explored the use of chemiluminescence in situ hybridization to detect B19 DNA on cord blood cells, amniotic fluid cells, and pleuric fluid cells from several cases of hydrops fetalis. B19 DNA was detected by using digoxigenin-labeled probes immunoenzymatically visualized with the chemiluminescent adamantil-1,2-dioxetane phenyl phosphate substrate for alkaline phosphatase. The luminescent signal emitted from the hybridized probes was detected, analyzed, and measured with a high-performance, low-light-level imaging luminograph connected to an optical microscope and to a personal computer for the quantification and localization of the chemiluminescent emission inside individual cells. (+info)The role of parvovirus B19 in the pathogenesis of giant cell arteritis: a preliminary evaluation. (5/736)
OBJECTIVE: To determine whether parvovirus B19 DNA is more likely to be present in the temporal arteries of patients with giant cell arteritis (GCA) than in the temporal arteries of control subjects. METHODS: We prospectively examined temporal artery biopsy (TAB) tissue from 50 consecutive patients presenting for TAB for the presence of B19 DNA using the polymerase chain reaction (PCR). Clinical and demographic information was obtained from the patients' medical records. A separate PCR analysis of 30 original tissue specimens was conducted at the Centers for Disease Control and Prevention (CDC) using primers directed toward another target sequence in the nonstructural coding area of B19. RESULTS: The 50 patients had an average age of 70.8 years; 27 (54%) were female. Amplicons for human beta-globulin, but not for cytomegalovirus, were produced for all tissue samples. The PCR results for B19 agreed in 29 of 30 samples tested by our institution and by the CDC (97% agreement; kappa = 0.9). A comparison of the B19 DNA analysis and the results of TAB indicated a statistically significant association between histologic evidence of GCA and the presence of B19 DNA in TAB tissue (chi2 = 10.38, P = 0.0013). CONCLUSION: These findings suggest that B19 may play a role in the pathogenesis of GCA. (+info)Prevalence of antibodies to human parvovirus B19 nonstructural protein in persons with various clinical outcomes following B19 infection. (6/736)
Persistent infections with human parvovirus B19 (B19) associated with debilitating chronic disease have been described, although evidence linking B19 to these more unusual clinical outcomes has been inconclusive. Recent reports have suggested that the development of antibodies to the B19 nonstructural protein (NS1) following B19 infection might be linked to development of severe arthropathy and chronic infection. To confirm these findings, the C-terminal region of the NS1 protein was expressed for use in Western blot assays for detection of anti-NS1 IgG antibodies in human serum. Among 91 persons tested, 0 of 20 not previously infected with B19, 9(36%) of 25 with past B19 infection, and 5 (12.5%) of 40 with recent B19 infection, had detectable anti-NS1 antibodies. Of 6 persons with chronic B19 infection, 2 had detectable antibodies to NS1. The presence of anti-NS1 antibodies did not appear to correlate with unusual clinical outcomes or chronic B19 infection. (+info)Evidence for infection of the human embryo with adeno-associated virus in pregnancy. (7/736)
Previous reports have demonstrated the presence of DNA of the human helper virus-dependent adeno-associated parvovirus (AAV) in uterine tissue and curettage material from early miscarriage. To examine infection of embryonic tissue during pregnancy, amnion fluids were analysed for the presence of AAV. Using polymerase chain reaction, AAV DNA was detected in 64 out of 238 DNA samples extracted from amnion cells. DNA of helper viruses were found in 12% (papillomavirus) and 18% (cytomegalovirus) of the samples (double infections with AAV in eight and nine cases, respectively). Furthermore, infectious AAV virions were found in 13 out of 43 AAV DNA-containing samples. In mothers with AAV DNA-positive amnion fluids, premature amniorrhexis and premature labour occurred significantly more frequently (P < 0.001). Using an immunofluorescence assay, 24% of newborn sera (unrelated to the amnion fluid samples) were found to contain IgM antibodies to AAV, in most cases paralleled by IgM antibodies in the mother's sera. The data demonstrate that AAV infection can occur in utero at early and at late stages of pregnancy. The observed complications at delivery should encourage studies to clarify possible pathological consequences of AAV infection in pregnancy and a possible latent infection of the fetus. (+info)A new method with general diagnostic utility for the calculation of immunoglobulin G avidity. (8/736)
The reference method for immunoglobulin G (IgG) avidity determination includes reagent-consuming serum titration. Aiming at better IgG avidity diagnostics, we applied a logistic model for the reproduction of antibody titration curves. This method was tested with well-characterized serum panels for cytomegalovirus, Epstein-Barr virus, rubella virus, parvovirus B19, and Toxoplasma gondii. This approach for IgG avidity calculation is generally applicable and attains the diagnostic performance of the reference method while being less laborious and twice as cost-effective. (+info)Parvoviridae infections refer to diseases caused by viruses belonging to the Parvoviridae family. These viruses are known to infect a wide range of hosts, including humans, animals, and insects. The most well-known member of this family is the human parvovirus B19, which is responsible for a variety of clinical manifestations such as:
1. Erythema infectiosum (Fifth disease): A common childhood exanthem characterized by a "slapped cheek" rash and a lace-like rash on the extremities.
2. Transient aplastic crisis: A sudden and temporary halt in red blood cell production, which can lead to severe anemia in individuals with underlying hematologic disorders.
3. Hydrops fetalis: Intrauterine death due to severe anemia caused by parvovirus B19 infection in pregnant women, leading to heart failure and widespread fluid accumulation in the fetus.
Parvoviruses are small, non-enveloped viruses with a single-stranded DNA genome. They primarily infect and replicate within actively dividing cells, making them particularly harmful to rapidly proliferating tissues such as bone marrow and fetal tissues. In addition to parvovirus B19, other Parvoviridae family members can cause significant diseases in animals, including cats, dogs, and livestock.
Parvoviridae is a family of small, non-enveloped viruses that infect a wide range of hosts, including humans, animals, and birds. These viruses have a single-stranded DNA genome and replicate in the nucleus of infected cells. They are resistant to heat, acid, and organic solvents, making them difficult to inactivate.
The family Parvoviridae is divided into two subfamilies: Parvovirinae and Densovirinae. Parvovirinae infect vertebrates, while Densovirinae infect invertebrates. The subfamily Parvovirinae includes several genera that infect various hosts, such as humans, dogs, cats, and primates.
Parvovirus B19 is a well-known member of this family that causes a variety of clinical manifestations in humans, including fifth disease (slapped cheek syndrome), arthralgia, and occasionally more severe diseases in immunocompromised individuals or those with certain hematological disorders.
In animals, parvoviruses can cause serious diseases such as canine parvovirus infection in dogs and feline panleukopenia in cats, which can be fatal if left untreated.
Parvovirus is a type of virus that is known to cause diseases in various animals, including dogs and humans. The most common strain that infects humans is called Parvovirus B19. This particular strain is responsible for the illness known as Fifth disease, which primarily affects young children and causes symptoms such as fever, rash, and joint pain.
Parvovirus B19 spreads through respiratory droplets, such as when an infected person coughs or sneezes. It can also be transmitted through blood or contaminated objects. Once the virus enters the body, it typically targets and infects rapidly dividing cells, particularly those found in the bone marrow and the fetal heart.
In dogs, a different strain of parvovirus called Canine Parvovirus (CPV) is responsible for a highly contagious and often fatal gastrointestinal illness. CPV primarily affects puppies between 6 weeks and 6 months old, but older dogs can also be infected if they haven't been vaccinated.
It is essential to maintain good hygiene practices and ensure proper vaccination to prevent parvovirus infections in both humans and animals.
A densovirus is a type of single-stranded DNA virus that belongs to the family Parvoviridae and the subfamily Densovirinae. These viruses are known to infect insects, including crustaceans and arthropods, and are often associated with diseases in these hosts. They have a small, icosahedral capsid and a linear, ssDNA genome that is around 5-6 kilobases in length. Densoviruses are non-enveloped viruses, meaning they do not have a lipid membrane surrounding their capsid.
It's important to note that densoviruses are not known to infect humans or other mammals, and therefore are not considered a threat to human health.
Parvovirinae is a subfamily of viruses in the family Parvoviridae, which includes small, non-enveloped viruses with single-stranded DNA genomes. This subfamily consists of several genera that infect various animals, including humans. The most well-known genus in this subfamily is Erythrovirus, which contains human parvovirus B19, a common cause of mild illness in humans, but also associated with more severe conditions such as fifth disease, aplastic anemia, and hydrops fetalis in pregnant women. Other genera in Parvovirinae infect various animals, such as dogs, cats, pigs, and mice.
Erythrovirus is a genus of viruses in the family *Polyomaviridae*. This genus includes several human viruses that were previously known as human mastadenoviruses. They are non-enveloped, double-stranded DNA viruses that primarily infect erythroid cells, hence the name Erythrovirus.
The most well-known member of this genus is Human parvovirus B19 (B19V), which is a human pathogen that causes several clinical manifestations, such as Fifth disease, aplastic crisis, and hydrops fetalis. The infection with B19V is usually self-limiting in healthy individuals; however, it can cause severe complications in immunocompromised patients or those with certain hematological disorders.
Other members of the Erythrovirus genus include Primate erythrovirus 1 (PEV-1) and Primate erythrovirus 2 (PEV-2), which have been identified in non-human primates. These viruses share genetic similarities with B19V, but their clinical significance remains unclear.
In summary, Erythrovirus is a genus of viruses that primarily infect erythroid cells and include several human pathogens, such as Human parvovirus B19, which can cause various clinical manifestations in humans.
Bocavirus is a type of virus that belongs to the Parvoviridae family. It is specifically classified under the genus Bocaparvovirus. This virus is known to infect humans and animals, causing respiratory and gastrointestinal illnesses. In humans, human bocavirus (HBoV) has been identified as a cause of acute respiratory tract infections, particularly in young children. There are four species of HBoV (HBoV1-4), but HBoV1 is the most common and best studied. It can be detected in nasopharyngeal swabs or washes, and it is often found as a co-infection with other respiratory viruses.
The medical definition of Bocavirus refers to this specific virus and its associated illnesses. The name "Bocavirus" comes from the initials of two diseases it causes in cattle: bovine parvovirus (BPV) and bovine rhinitis (BRSV) complex. In addition to humans, Bocaviruses have been identified in various animals, including dogs, cats, pigs, and non-human primates.
Circoviridae is a family of small, non-enveloped viruses that infect a wide range of hosts, including birds, pigs, and some primates. The virions of Circoviridae are icosahedral in shape and have a diameter of approximately 20 nanometers. The genome of these viruses is circular, single-stranded DNA that is around 2 kilobases in length.
The family Circoviridae includes two genera: Circovirus and Gyrovirus. Circoviruses are known to infect birds and pigs, while gyroviruses primarily infect birds. The most well-known circovirus is the porcine circovirus (PCV), which can cause a variety of clinical signs in pigs, including respiratory disease, enteritis, and reproductive failure. Gyroviruses, on the other hand, have been associated with various diseases in birds, such as inclusion body hepatitis and lymphoproliferative disease.
It's worth noting that circoviruses have also been detected in humans, although their clinical significance is not yet fully understood. Some studies have suggested a possible link between human circovirus infection and certain diseases, such as cardiovascular disease and diabetes, but more research is needed to confirm these findings.
A viral genome is the genetic material (DNA or RNA) that is present in a virus. It contains all the genetic information that a virus needs to replicate itself and infect its host. The size and complexity of viral genomes can vary greatly, ranging from a few thousand bases to hundreds of thousands of bases. Some viruses have linear genomes, while others have circular genomes. The genome of a virus also contains the information necessary for the virus to hijack the host cell's machinery and use it to produce new copies of the virus. Understanding the genetic makeup of viruses is important for developing vaccines and antiviral treatments.
Phylogeny is the evolutionary history and relationship among biological entities, such as species or genes, based on their shared characteristics. In other words, it refers to the branching pattern of evolution that shows how various organisms have descended from a common ancestor over time. Phylogenetic analysis involves constructing a tree-like diagram called a phylogenetic tree, which depicts the inferred evolutionary relationships among organisms or genes based on molecular sequence data or other types of characters. This information is crucial for understanding the diversity and distribution of life on Earth, as well as for studying the emergence and spread of diseases.
DNA Sequence Analysis is the systematic determination of the order of nucleotides in a DNA molecule. It is a critical component of modern molecular biology, genetics, and genetic engineering. The process involves determining the exact order of the four nucleotide bases - adenine (A), guanine (G), cytosine (C), and thymine (T) - in a DNA molecule or fragment. This information is used in various applications such as identifying gene mutations, studying evolutionary relationships, developing molecular markers for breeding, and diagnosing genetic diseases.
The process of DNA Sequence Analysis typically involves several steps, including DNA extraction, PCR amplification (if necessary), purification, sequencing reaction, and electrophoresis. The resulting data is then analyzed using specialized software to determine the exact sequence of nucleotides.
In recent years, high-throughput DNA sequencing technologies have revolutionized the field of genomics, enabling the rapid and cost-effective sequencing of entire genomes. This has led to an explosion of genomic data and new insights into the genetic basis of many diseases and traits.
Viral DNA refers to the genetic material present in viruses that consist of DNA as their core component. Deoxyribonucleic acid (DNA) is one of the two types of nucleic acids that are responsible for storing and transmitting genetic information in living organisms. Viruses are infectious agents much smaller than bacteria that can only replicate inside the cells of other organisms, called hosts.
Viral DNA can be double-stranded (dsDNA) or single-stranded (ssDNA), depending on the type of virus. Double-stranded DNA viruses have a genome made up of two complementary strands of DNA, while single-stranded DNA viruses contain only one strand of DNA.
Examples of dsDNA viruses include Adenoviruses, Herpesviruses, and Poxviruses, while ssDNA viruses include Parvoviruses and Circoviruses. Viral DNA plays a crucial role in the replication cycle of the virus, encoding for various proteins necessary for its multiplication and survival within the host cell.
Molecular sequence data refers to the specific arrangement of molecules, most commonly nucleotides in DNA or RNA, or amino acids in proteins, that make up a biological macromolecule. This data is generated through laboratory techniques such as sequencing, and provides information about the exact order of the constituent molecules. This data is crucial in various fields of biology, including genetics, evolution, and molecular biology, allowing for comparisons between different organisms, identification of genetic variations, and studies of gene function and regulation.
Parvoviridae
Ungulate protoparvovirus 1
Hepanhamaparvovirus
Flacherie
Minute virus of mice
Self-complementary adeno-associated virus
Carnivore protoparvovirus 1
Viral neuronal tracing
Alphatorquevirus
Canine parvovirus
Sea star-associated densovirus
Mink enteritis virus
Endogenous viral element
Helper dependent virus
Human bocavirus
Cricket paralysis virus
Monodnaviria
Viral disease
Carnivore bocaparvovirus 1
Tetraparvovirus
Bocaparvovirus
Adeno-associated virus
Cetacean microbiome
SMEDI
Derzsy's disease
Amdoparvovirus
Aleutian disease
Dependoparvovirus
Parvovirus B19
Viral replication
Viral infections as potential triggers of type 1 diabetes
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PARV4: an emerging tetraparvovirus. - Nuffield Department of Medicine
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Genus9
- Parvovirus B19 (B19V) is a single-stranded DNA virus of the family Parvoviridae and genus Erythrovirus. (medscape.com)
- Human bocavirus (HBoV), a new member of the genus Bocavirus in the family Parvoviridae , has been recently associated with respiratory tract infections. (cdc.gov)
- This newly identified virus shares a high sequence identity and a similar genomic organization with bovine parvovirus and canine minute virus, 2 related members of the Bocavirus genus in the Parvovirinae subfamily of the Parvoviridae family, and it was provisionally named human bocavirus (HBoV). (cdc.gov)
- AAV belongs to the Parvoviridae family and Dependovirus genus, whose members require co-infection with a helper virus such as adenovirus to promote replication, and AAV establishes a latent infection in the absence of a helper. (justia.com)
- Single-stranded DNA virus, member of Parvoviridae, genus Erythrovirus. (unboundmedicine.com)
- strong course="kwd-title" Keywords: Antibodies, Bloodstream protection, Donation deferral period, Defense response, Parvovirus B19, Plasma donation, Transfusion-associated attacks Launch Parvovirus B19 (B19V) can be an Erythrovirus (genus) from the Parvoviridae family members. (ourownfuture.org)
- Waterfowl parvoviruses, including goose parvoviruses (GPVs), Muscovy duck parvoviruses (MDPVs) and the variant viruses of GPVs and MDPVs, were renamed as Anseriform dependoparvovirus 1 by the International Committee on Taxonomy of Viruses (ICTV) and have been assigned to the genus Dependoparvovirus in subfamily Parvovirinae under family Parvoviridae based on similarities in phylogenetic properties ( https://talk.ictvonline.org/taxonomy/ ). (biomedcentral.com)
- In the parvoviridae family it belongs to the genus dependoparvovirus, because it needs the presence of a helper virus for replication and assembly. (progen.com)
- Adeno-associated virus hails from the genus Dependoparvovirus, which in turn belongs to the family Parvoviridae. (technewspoint.com)
Parvovirus B1910
- The images below provide examples of symptoms observed with parvovirus B19 infection. (medscape.com)
- Rare individuals who lack the P antigen are immune to parvovirus B19 infection. (medscape.com)
- Parvovirus B19 infection is extremely common. (medscape.com)
- This report* was developed to assist physicians, public health officials, and other health-care professionals respond to public concerns about recently recognized, serious complications of human parvovirus B19 (B19) infection, including transient aplastic crisis (TAC), chronic anemia, and fetal death. (cdc.gov)
- Pancreas allograft thrombosis following intravenous immunoglobulin administration to treat parvovirus B19 infection. (ox.ac.uk)
- This case report describes a patient who developed graft thrombosis after intravenous immunoglobulin administration to treat acute parvovirus B19 infection. (ox.ac.uk)
- In contrast to human parvovirus B19 infections, PARV4 infections are most frequently detected in injection drug users (IDUs), particularly those who are coinfected with HIV type 1 (HIV-1). (ox.ac.uk)
- Parvovirus B19 is the cause of human infection but is not a "parvovirus" technically, as is the case with many mammalian species that have strains of parvovirus that cause infection. (unboundmedicine.com)
- Fifth disease is a mild viral infection caused by human parvovirus B19. (diseasesdic.com)
- Once you recover from fifth disease, you develop immunity that generally protects you from parvovirus B19 infection in the future. (diseasesdic.com)
Humans1
- Although correlations between clinical presentation with T1D and the occurrence of a viral infection that precedes the development of overt disease have been recognized, causalities between viruses and the diabetogenic process are still elusive and difficult to prove in humans. (nih.gov)
Erythrovirus1
- G. Siegl and P. Cassinotti, "Parvoviruses" Chapter 14, Topley and Wison's Microbiology and Microbial Infections, Vol. 1, Virology, 1998 pp. 261-280 ] It is classified as Erythrovirus because of its capability to invade red blood cell precursors in the bone marrow . (en-academic.com)
Subfamily1
- According to the current state of knowledge, the family Parvoviridae comprises three subfamilies, with the subfamily Parvovirinae covering the genera which are important for vertebrates. (laboklin.com)
Parvoviruses4
- Parvoviruses are a family of animal viruses that constitute the family Parvoviridae. (wikipedia.org)
- Widespread infection with homologues of human parvoviruses B19, PARV4, and human bocavirus of chimpanzees and gorillas in the wild. (ox.ac.uk)
- Infections with human parvoviruses B19 and recently discovered human bocaviruses (HBoVs) are widespread, while PARV4 infections are transmitted parenterally and prevalent specifically in injecting drug users and hemophiliacs. (ox.ac.uk)
- Evidence for widespread infection of hemophiliacs treated with nonvirally inactivated clotting factor creates fresh safety concerns for plasma-derived blood products, particularly because parvoviruses are relatively resistant to virus inactivation. (ox.ac.uk)
Family7
- Parvoviridae is the sole family in the order Piccovirales, which is the sole order in the class Quintoviricetes. (wikipedia.org)
- Human bocavirus (a member of the Parvoviridae virus family) is a newly described human pathogen that has been associated with lower respiratory tract and gastrointestinal infections, predominantly in children. (medscape.com)
- Background Human parvovirus B19V is a DNA virus, and a member of the family Parvoviridae, that causes various clinical manifestations, from asymptomatic to persistent infection that is associated with different autoimmune diseases. (teagasc.ie)
- Human PV-B19, a member of the family Parvoviridae, is a heat-stable, single-stranded DNA virus. (diseasesdic.com)
- The "B19 virus" belongs to the Parvoviridae family of small DNA viruses. (en-academic.com)
- The adeno-associated virus (AAV) is a small (25 nm), non-enveloped virus of the parvoviridae family, including 12 different AAV serotypes. (progen.com)
- A highly contagious and fatal disease of cats, particularly young cats, caused by feline panleukopenia virus, a member of the family Parvoviridae, and manifested by severe leukopenia, prostration, fever, vomiting and diarrhea. (wordinfo.info)
Viruses7
- Future studies will hopefully reveal which human viruses are causally involved in the induction of T1D and this knowledge may provide directions on how to deal with viral infections in diabetes-susceptible individuals in order to delay or even prevent the diabetogenic process. (nih.gov)
- Respiratory syncytial virus (RSV), influenza A and B viruses, parainfluenza viruses, human adenoviruses, rhinoviruses, coronaviruses, and the more recently identified human metapneumovirus (HMPV) all cause respiratory tract infections. (cdc.gov)
- Our recent studies identified a scavenger receptor, LDL receptor related protein 1 (Lrp1), as a potential pro-viral host factor for RVFV and related viruses, including Oropouche virus (OROV) infection. (bvsalud.org)
- It seems that some of the "junk" sequences from our DNA are pieces of viruses left from an infection within a distant ancestor. (healththoroughfare.com)
- Recombinant adeno-associated viruses (AAV) are one of the leading vectors for gene therapy applications that deliver gene-editing enzymes, antibodies, and RNA interference molecules to eliminate viral reservoirs that fuel persistent infections. (biomedcentral.com)
- The co-infection with one of the AAV helper viruses leads to the initiation of AAV gene expression, replication and the production of AAV virions. (progen.com)
- Sequences from ancestral single-stranded DNA viruses in vertebrate genomes: the parvoviridae and circoviridae are more than 40 to 50 million years old. (virology.ws)
Intravenous1
- We define the acute onset of PARV4 infection and the characteristics of the acute-phase and memory immune responses to PARV4 in a group of HCV- and HIV-negative, active intravenous drug users. (ox.ac.uk)
Respiratory tract inf1
- We report the epidemiologic and clinical features observed from a 1-year retrospective study of HBoV infection in young children hospitalized with a respiratory tract infection. (cdc.gov)
Adenoviridae2
- This graph shows the total number of publications written about "Adenoviridae Infections" by people in this website by year, and whether "Adenoviridae Infections" was a major or minor topic of these publications. (ucdenver.edu)
- Below are the most recent publications written about "Adenoviridae Infections" by people in Profiles. (ucdenver.edu)
Fungal infections2
- and ectoparasite infestations, and pelts should be examined for evidence of fungal infections and ectoparasites, such as lice (ie, Stachiella larseni ). (msdvetmanual.com)
- Neutropenia is a serious disorder because it makes the body vulnerable to bacterial and fungal infections. (wordinfo.info)
Asymptomatic1
- In outbreak investigations, asymptomatic infection has been reported in approximately 20% of children and adults (19,20). (cdc.gov)
Diseases1
- It is also known as food poisoning, food infection, stomach flu, and winter vomiting diseases. (sanfoundry.com)
Filoviridae1
- The Bornaviridae, Parvoviridae, and the Filoviridae endogenous viral elements (EVE) were found. (healththoroughfare.com)
Phylogenetic1
- We report the incidence and seasonal distribution of HBoV, provide a phylogenetic analysis of HBoV isolates, and describe clinical characteristics of HBoV infection. (cdc.gov)
PARV47
- Evolution of CD8+ T cell responses after acute PARV4 infection. (ox.ac.uk)
- PARV4 is a small DNA human virus that is strongly associated with hepatitis C virus (HCV) and HIV infections. (ox.ac.uk)
- The immunologic control of acute PARV4 infection has not been previously described. (ox.ac.uk)
- Ninety-eight individuals at risk of blood-borne infections were tested for PARV4 IgG. (ox.ac.uk)
- Gamma interferon enzyme-linked immunosorbent spot assays, intracellular cytokine staining, and a tetrameric HLA-A2-peptide complex were used to define the T cell populations responding to PARV4 peptides in those individuals who acquired infection during the study. (ox.ac.uk)
- Thus, PARV4 infection is common in individuals exposed to blood-borne infections, independent of their HCV or HIV status. (ox.ac.uk)
- To investigate the routes of transmission of PARV4 and to ascertain whether infections are acquired through plasma-derived blood products, we developed a novel anti-PARV4 enzyme-linked immunosorbent assay (ELISA) to determine its seroprevalence in subjects with parenteral exposure. (ox.ac.uk)
Bacterial2
- Topical therapies are often geared at assisting with control of secondary bacterial and yeast infections, and restoring the skin barrier function. (gulfanimalhospital.com)
- Systemic antibiotics or antifungals may be needed for patients with severe skin bacterial or yeast infections. (gulfanimalhospital.com)
Widespread1
- Both GPVs and MDPVs infections are widespread in China, causing huge economic loss due to the high mortality and morbidity within waterfowl husbandry industries. (biomedcentral.com)
Susceptibility1
- Susceptibility to acute mouse adenovirus type 1 respiratory infection and establishment of protective immunity in neonatal mice. (ucdenver.edu)
Children hospitalized1
- [ 1 ] Analysis of samples from children hospitalized with lower respiratory tract infections and children with acute wheezing episodes has provided infection rates of 2-20% from various areas of the world. (medscape.com)
Endogenous1
- For example, it has been suggested that synthesis of the bornaviral N protein from endogenous sequences might render the host resistant to infection with bornaviruses. (virology.ws)
Human bocavirus1
- The high rate of infection, along with the codetection of other viral pathogens (or simply not ruling out other common virus infections in some studies), has caused some researchers to question whether human bocavirus is a primary cause of disease, a contributor to more severe disease, or simply a passenger virus that is coincidentally found with other infections. (medscape.com)
Erythema Infectiosum1
- The development of erythema infectiosum in children is a normal response to infection by PV-B19. (diseasesdic.com)
Systemic1
- however, a definite trend towards higher levels of DNAemia is observed in symptomatic children, and DNA levels decline with resolution of symptoms, suggesting that systemic infection is a feature of more acute infection. (medscape.com)
Severe3
- These guidelines reflect both the current limited information about the extent to which B19 infection leads to severe complications and the limited availability of diagnostic testing. (cdc.gov)
- A CHIKV infection causes fever and severe joint pain. (microbiologyclass.net)
- IgM antibodies are discovered CGP77675 past due in the viremic stage C about time 10-12 using a top at time 15-22 C and will persist weeks or a few months after the severe infections [12,13,14,15]. (ourownfuture.org)
Clinical signs2
- To investigate epidemiologic features of this virus and further specify clinical signs associated with HBoV infections, we retrospectively tested respiratory specimens from children obtained during a 1-year period. (cdc.gov)
- The virus may be shed in feces even in the absence of clinical signs (subclinical infections), or before clinical signs are detected (Barrs 2019). (bioguardlabs.com)
Acute infection2
- Persistent and functional T cell responses were detected in the acute infection phase. (ox.ac.uk)
- Acute infection in a host who is immunocompetent leads to a Th-1-mediated cellular immune response, with the production of specific immunoglobulin M (IgM) antibodies and subsequent formation of immune complexes. (diseasesdic.com)
Gastrointestinal1
- Pets with food allergy may have primarily dermatologic symptoms (itching with or without skin lesions, ear and or skin infections), gastrointestinal symptoms (vomiting, diarrhea) or both. (gulfanimalhospital.com)
Prevalent1
- B19V is certainly a prevalent world-wide infections common in human beings. (ourownfuture.org)
Factors2
- This increase suggests that besides genetical factors environmental perturbations (including viral infections) are also involved in the pathogenesis of T1D. (nih.gov)
- Given the significant roles of viral and host factors during infection, characterization of these interactions is critical for therapeutic targeting with neutralizing antibodies and vaccines. (bvsalud.org)
Chronic2
- Fur chewing decreases value of the pelt, and chronic tail biting may result in infection or fatal hemorrhage. (msdvetmanual.com)
- Patients with atopic dermatitis often suffer from relapsing skin infections, and chronic inflammation of the skin leading to hyperpigmentation (increased skin pigment) and lichenification (thickening of the skin) in affected areas. (gulfanimalhospital.com)
Adenovirus3
- The Dependovirus adeno-associated virus (AAV) is a small parvovirus that requires a helper co-infection to replicate (either adenovirus or herpes simplex virus) and is not directly associated with a disease in its own right. (medscape.com)
- Prostaglandin E2 production during neonatal respiratory infection with mouse adenovirus type 1. (ucdenver.edu)
- Prostaglandin E2 Production and T Cell Function in Mouse Adenovirus Type 1 Infection following Allogeneic Bone Marrow Transplantation. (ucdenver.edu)
Persistent1
- As long-lived viral DNA within specific cellular reservoirs is responsible for persistent hepatitis B virus, Herpes simplex virus, and human immunodeficiency virus infections, the discovery of AAV vectors with strong tropism for hepatocytes, sensory neurons and T cells, respectively, is of particular interest. (biomedcentral.com)
B19V5
- Although B19V infection may manifest with pancytopenia, it is not believed to contribute significantly as an etiology of true aplastic anemia. (medscape.com)
- Bottom line This scholarly research of B19V-DNA fill and degrees of neopterin, IgM, and IgG permits reliable distribution and characterization in to the different levels of B19V infections. (ourownfuture.org)
- nevertheless, in some individual groupings (e.g., women that are pregnant, sufferers with hemophilia, immunodeficient sufferers, and fetuses) B19V infections may take a far more serious training course [2,3]. (ourownfuture.org)
- B19V infections evolution is seen as a a 5-time stage with high viremia (titer about 1014 IU/ml B19V DNA) [6,7,8]. (ourownfuture.org)
- When the mobile immune system response is turned on, neopterin amounts (6-D-erythro-trihydroxipropilpterin) boost also in B19V infections [18]. (ourownfuture.org)
Resistant1
- Few people are resistant to HIV infection as they are homozygous for an allele of the CCR5 gene that cannot express a functional protein. (sanfoundry.com)
Fetal1
- This may explain some of the direct myocardial effects seen in fetal infection. (medscape.com)
Disease6
- Evidence of recent infection (viral antigen, immunoglobulin M [IgM]-specific antibodies to the virus) was first found in the blood of Jamaican children living in London, England, all of whom presented with transient aplastic crisis (TAC) of sickle cell disease . (medscape.com)
- Often, the viral load of the co-infection is relatively low, which supports the idea that the symptoms may have been worsened by the presence of the infection because these samples are usually taken from hospitalized patients, who are, by definition, suffering from more serious respiratory disease. (medscape.com)
- Therapy is aimed at control of pruritus, reduction of skin inflammation and restoration of the skin barrier, treatment of secondary infections and long-term management of the disease to reduce flares. (gulfanimalhospital.com)
- According to the structural organization of micro-organisms and parasites, identify the necessary facilities / functions to perform the metabolic processes and replication and to determine the infection / disease in the host. (unict.it)
- GPV infection, also known as Derzsy's disease in Europe, was described in China by Professor Fang in the early 1960s [ 4 ]. (biomedcentral.com)
- Muscovy duck parvovirus infection, also known as "three-week" disease in China, was initially described by Professor Lin in our laboratory in the early 1990s [ 5 ]. (biomedcentral.com)
Immune5
- Additionally, PLpro can cleave both ubiquitin and the ubiquitin-like protein ISG15 from host cell substrates as a mechanism to evade innate immune responses during infection. (bvsalud.org)
- Individuals with B19 IgG antibodies are generally considered immune to recurrent infection, but reinfection is possible in a minority of cases. (en-academic.com)
- About half of adults are B19-immune due to a past infection. (en-academic.com)
- Puppies of immune female dogs are usually protected from parvovirus infection for about 2 to 3 months through the uptake of maternal antibodies in colostrum. (laboklin.com)
- Inbred mouse lines vary in their ability to mount protective antiretroviral immune responses, and even closely related strains can exhibit opposing phenotypes upon retroviral infection. (ebsco.com)
Canine2
- 1980). Clinical picture Clinically, canine parvovirus infection is characterised by gastroenteritis with haemorrhagic diarrhoea and vomiting. (laboklin.com)
- formerly FPL virus) and canine parvovirus (CPV), however, CPV infections in cats are uncommon (Barrs 2019). (bioguardlabs.com)
Contrast2
- In contrast, RVFV infection levels in other tissues showed no difference between the two genotypes. (bvsalud.org)
- In contrast to GPV, MDPV infection occurs only in Muscovy ducklings and is characterized by watery diarrhoea, wheezing, and locomotor dysfunction. (biomedcentral.com)
Symptoms2
- The rash and joint symptoms usually occur 2-3 weeks after initial infection. (medscape.com)
- Joint symptoms, more common in adults, may occur as the sole manifestation of infection. (cdc.gov)
Patients1
- In addition, interim guidelines are presented for preventing B19 infection, managing persons exposed to persons with B19 infection, and managing patients infected with B19. (cdc.gov)
MeSH1
- Hepadnaviridae Infections" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
Tropism1
- [ 2 , 12 ] This, coupled with the tropism for rapidly dividing erythrocyte precursors (particularly pronormoblasts and normoblasts, wherein they replicate to high titers), leads to the suppression of erythrogenesis seen during infection. (medscape.com)