Pancreatic Neoplasms
Neoplasms
Neoplasms, Cystic, Mucinous, and Serous
Neoplasms, Multiple Primary
Neoplasms, Second Primary
Adenocarcinoma, Mucinous
Myeloproliferative Disorders
Male circumcision: assessment of health benefits and risks. (1/234)
OBJECTIVES: Globally approximately 25% of men are circumcised for religious, cultural, medical, or parental choice reasons. However, controversy surrounds the procedure, and its benefits and risks to health. We review current knowledge of the health benefits and risks associated with male circumcision. METHODS: We have used, where available, previously conducted reviews of the relation between male circumcision and specific outcomes as "benchmarks", and updated them by searching the Medline database for more recent information. RESULTS: There is substantial evidence that circumcision protects males from HIV infection, penile carcinoma, urinary tract infections, and ulcerative sexually transmitted diseases. We could find little scientific evidence of adverse effects on sexual, psychological, or emotional health. Surgical risks associated with circumcision, particularly bleeding, penile injury, and local infection, as well as the consequences of the pain experienced with neonatal circumcision, are valid concerns that require appropriate responses. CONCLUSION: Further analyses of the utility and cost effectiveness of male circumcision as a preventive health measure should, in the light of this information, be research and policy priorities. A decision as to whether to recommend male circumcision in a given society should be based upon an assessment of the risk for and occurrence of the diseases which are associated with the presence of the foreskin, versus the risk of the complications of the procedure. In order for individuals and their families to make an informed decision, they should be provided with the best available evidence regarding the known benefits and risks. (+info)Penile intraepithelial neoplasia--a veiled lesion in genitourinary medicine. (2/234)
Penile intraepithelial neoplasia (PIN) is a clinically well known condition. However, its diagnosis is often difficult. We present four cases of PIN, seen in our department. Various histological patterns ranging from PIN I to PIN III were noted in these cases. (+info)Tumours of the prostate and penis. (3/234)
Tumours of the male genital tract, excluding the testes, are relatively rare in the six major domestic animals. The most important tumours are prostate carcinoma and transmissible venereal tumour of the penis in dogs, fibropapilloma of the penis in bulls, squamous papilloma and squamous cell carcinoma in horses, and squamous papilloma in pigs. Four histological types of canine prostate carcinoma exist: alveolar papillary, acinar, organoid, and poorly differentiated. The biological behaviour of prostate carcinomas is similar to that in man, with frequent metastasis to the regional pelvic nodes, bones, and lungs. There appears to be no relationship between the common diffuse glandular hyperplasia and carcinoma in the prostate of dogs. A unique lesion of dogs is squamous metaplasia of the prostate related to estrogen-producing Sertoli cell tumours of the testis. Three different transmissible tumours of the penis occur in domestic animals. The canine venereal tumours can be transmitted only by intact tumour cells during licking and coital contact, whereas bovine fibropapillomas and porcine squamous papillomas can be transmitted by cell-free material. In cattle, the fibropapillomas are caused by the same virus that produces cutaneous papillomatosis. All three tumours are benign and usually regress spontaneously. (+info)Distinct patterns of alteration of myc genes associated with integration of human papillomavirus type 16 or type 45 DNA in two genital tumours. (4/234)
We previously described two genital carcinomas (IC2, IC4) containing human papillomavirus type 16 (HPV-16)- or HPV-18-related sequences integrated in chromosomal bands containing the c-myc (8q24) or N-myc (2p24) gene, respectively. The c-myc gene was rearranged and amplified in IC2 cells without evidence of overexpression. The N-myc gene was amplified and highly transcribed in IC4 cells. Here, the sequence of an 8039 bp IC4 DNA fragment containing the integrated viral sequences and the cellular junctions is reported. A 3948 bp segment of the genome of HPV-45 encompassing the upstream regulatory region and the E6 and E7 ORFs was integrated into the untranslated part of N-myc exon 3, upstream of the N-myc polyadenylation signal. Both N-myc and HPV-45 sequences were amplified 10- to 20-fold. The 3' ends of the major N-myc transcript were mapped upstream of the 5' junction. A minor N-myc/HPV-45 fusion transcript was also identified, as well as two abundant transcripts from the HPV-45 E6-E7 region. Large amounts of N-myc protein were detected in IC4 cells. A major alteration of c-myc sequences in IC2 cells involved the insertion of a non-coding sequence into the second intron and their co-amplification with the third exon, without any evidence for the integration of HPV-16 sequences within or close to the gene. Different patterns of myc gene alterations may thus be associated with integration of HPV DNA in genital tumours, including the activation of the protooncogene via a mechanism of insertional mutagenesis and/or gene amplification. (+info)Erythroplasia of queyrat: coinfection with cutaneous carcinogenic human papillomavirus type 8 and genital papillomaviruses in a carcinoma in situ. (5/234)
Erythroplasia of Queyrat is a carcinoma in situ that mainly occurs on the glans penis, the prepuce, or the urethral meatus of elderly males. Up to 30% progress to squamous cell carcinoma. The cause of erythroplasia of Queyrat is largely unknown. Human papillomavirus type 16 DNA has previously been detected only in very few distinctly characterized patients. We have investigated 12 paraffin-embedded biopsies from eight patients with penile erythroplasia of Queyrat and control biopsies of inflammatory penile lesions, of genital Bowen's disease, and of premalignant/malignant cervical or vulvar lesions by 10 different polymerase chain reaction protocols for the presence of cutaneous and genital/mucosal human papillomaviruses. Human papillomavirus typing was performed by sequencing (cloned) polymerase chain reaction products. Human papillomavirus DNA was detected in all erythroplasia of Queyrat patients and in none of the controls with inflammatory penile lesions. The rare cutaneous carcinogenic epidermodysplasia verruciformis-associated human papillomavirus type 8 was present in all erythroplasia of Queyrat patients and the genital high-risk human papillomavirus type 16 in seven of eight patients (88%). In addition to human papillomavirus type 8 and human papillomavirus type 16, four patients carried the genital carcinogenic human papillomavirus type 39 and/or type 51. All human papillomavirus type 8 sequences found in erythroplasia of Queyrat showed some polymorphism among each other and differed in specific nucleotide exchanges from the human papillomavirus type 8 reference sequence. Viral load determinations (human papillomavirus copies/beta-globin gene copies) by realtime polymerase chain reactions showed that the human papillomavirus type 16 levels in the erythroplasia of Queyrat biopsies were one to five orders of magnitude higher than the human papillomavirus type 8 levels. Human papillomavirus type 8 was not detected in cervical or vulvar precancerous and cancerous lesions and in Bowen's disease lesions that carried genital human papillomavirus types. The data suggest that in erythroplasia of Queyrat, in contrast to other genital neoplasias, a coinfection with human papillomavirus type 8 and carcinogenic genital human papillomavirus types occurs. The presence or absence of human papillomavirus type 8 might help to distinguish between penile erythroplasia of Queyrat and Bowen's diseases. (+info)Human papillomavirus-associated cancers in patients with human immunodeficiency virus infection and acquired immunodeficiency syndrome. (6/234)
BACKGROUND: Human papillomavirus (HPV)-associated anogenital malignancies occur frequently in patients with human immunodeficiency virus (HIV) infection and the acquired immunodeficiency syndrome (AIDS). The purpose of our study was to determine if the high frequency of these cancers is due to lifestyle factors associated with both HPV and HIV infections or to immunosuppression following HIV infection. METHODS: We studied invasive and in situ HPV-associated cancers among 309 365 U.S. patients with HIV infection/AIDS (257 605 males and 51 760 females) from 5 years before the date of AIDS onset to 5 years after this date. Sex-, race-, and age-standardized ratios of observed-to-expected cancers served as measures of relative risk (RR). Trend tests were used to evaluate changes in the RRs during the 10 years spanning AIDS onset. All statistical tests were two-sided. RESULTS: All HPV-associated cancers in AIDS patients occurred in statistically significant excess compared with the expected numbers of cancers. For in situ cancers, overall risks were significantly increased for cervical (RR = 4.6; 95% confidence interval [CI] = 4.3-5.0), vulvar/vaginal (RR = 3.9; 95% CI = 2.0-7. 0), anal (in females, RR = 7.8 [95% CI = 0.2-43.6]; in males, RR = 60.1 [95% CI = 49.2-72.7]), and penile (RR = 6.9; 95% CI = 4.2-10.6) cancers, and RRs increased during the 10 years spanning AIDS onset for carcinomas in situ of the cervix (P: for trend <.001), vulva/vagina (P: for trend =.04), and penis (P: for trend =.04). For invasive cancers, overall risks were significantly increased for cervical (RR = 5.4; 95% CI = 3.9-7.2), vulvar/vaginal (RR = 5.8; 95% CI = 3.0-10.2), and anal (RR = 6.8; 95% CI = 2.7-14.0) cancers in females and for anal (RR = 37.9; 95% CI = 33.0-43.4), penile (RR = 3. 7; 95% CI = 2.0-6.2), tonsillar (RR = 2.6; 95% CI = 1.8-3.8), and conjunctival (RR = 14.6; 95% CI = 5.8-30.0) cancers in males. However, RRs for invasive cancers changed little during the 10 years spanning AIDS onset. CONCLUSIONS: HPV-associated malignancies occur at increased rates in persons with HIV/AIDS. Increasing RRs for in situ cancers to and beyond the time of AIDS onset may reflect the gradual loss of control over HPV-infected keratinocytes with advancing immunosuppression. However, the lack of a similar increase for invasive HPV-associated cancers suggests that late-stage cancer invasion is not greatly influenced by immune status. (+info)Identification and functional analysis of sequence rearrangements in the long control region of human papillomavirus type 16 Af-1 variants isolated from Ugandan penile carcinomas. (7/234)
Human papillomavirus type 16 (HPV-16) is the predominant HPV isolate found in malignancies of male and female lower genital tracts. However, only a small percentage of individuals infected with high-risk HPVs develop a genital neoplasia, suggesting that additional events at both the cellular and the virus level are necessary for the progression to cancer, including genetic mutations/rearrangements of viral sequences involved in the oncogenic process. In this study, the genetic stability of the long control region (LCR) (nt 7289-114), which regulates expression levels of oncoproteins E6 and E7, was analysed in HPV-16 isolates from penile carcinoma (PC) biopsies of patients recruited from Uganda, one of the countries with the highest incidence of genital cancers in both men and women. Nucleotide changes within the LCR region typical of the African-1 (Af-1) lineage were observed in all HPV-16 isolates. Two out of five samples showed further rearrangements of the enhancer region. The functional activity of LCR with Af-1 mutations and/or rearrangements was evaluated by cloning each LCR into CAT expression vectors, followed by transfection in several epithelial and non-epithelial cell lines. CAT expression levels driven by a rearranged LCR were significantly higher than those driven by Af-1 or European prototype LCRs. Furthermore, in the NIH3T3 focus formation assay, the transforming activity of E6 and E7 genes, driven by a mutated or rearranged LCR, was 1.4- to 3.0-fold higher, respectively. These results indicate that rearrangements within the LCR of HPV-16 isolated from African PCs are frequently found (2 out of 5, 40%). It is also shown that increased HPV LCR activity is associated with an increased E6/E7-mediated in vitro transforming activity, suggesting that natural variants can play a major role in the pathogenesis of genital carcinomas. (+info)Intra-arterial chemotherapy in locally advanced or recurrent carcinomas of the penis and anal canal: an active treatment modality with curative potential. (8/234)
The prognosis of locally advanced or recurrent carcinomas of the penis (PE) and of the anal canal (AC) after conventional treatment is dismal. We report 16 patients (eight with AC carcinomas and eight with PE cancers) treated by intra-arterial (IA) chemotherapy. Fifteen of them were treated for locally advanced or recurrent disease and one in an adjuvant setting. The chemotherapy was administered via a femoral IA catheter with its tip located above the aortic bifurcation, under the inferior mesenteric artery. It consisted of eight push injections, given over a 48-h period, of the following drug combination: cisplatin 8.5 mg m(-2), 5-FU 275 mg m(-2), methotrexate 27.5 mg m(-2), mitomycin C 1.2 mg m(-2), and bleomycin 4 mg m(-2). Leucovorin was given po, 4 x 15 mg day(-1), during the chemotherapy and for 3 days thereafter. A total of 52 cycles of treatment were administered. Of the 15 patients evaluable for response, six obtained a CR (three PE, three AC) and eight a PR. Among the complete responders, four are alive and disease-free 2-15 years after treatment. The other patients enjoyed an objective response lasting 3-25 months (median 7 months). Four patients developed grade III/IV haematological toxicity with three episodes of febrile neutropenia, one of them with a fatal outcome due to patient's failure to obtain medical attention at the onset of his fever, one a grade III mucositis of the glans, and four a grade III/IV cutaneous toxicity, the latter caused by the IA administration of bleomycin. In conclusion, IA chemotherapy is effective and potentially curative in locoregionally advanced or recurrent carcinomas of the penis and of the anus. Its contribution in the primary management of advanced penile or anal carcinoma should be prospectively investigated. (+info)Penile neoplasms refer to abnormal growths or tumors in the penis. These can be benign (non-cancerous) or malignant (cancerous). The most common type of penile cancer is squamous cell carcinoma, which begins in the flat cells that line the surface of the penis. Other types of penile cancer include melanoma, basal cell carcinoma, and adenocarcinoma.
Benign penile neoplasms include conditions such as papillomas, condylomas, and peyronie's disease. These growths are usually not life-threatening, but they can cause discomfort, pain, or other symptoms that may require medical treatment.
It is important to note that any unusual changes in the penis, such as lumps, bumps, or sores, should be evaluated by a healthcare professional to determine the underlying cause and appropriate treatment.
Pancreatic neoplasms refer to abnormal growths in the pancreas that can be benign or malignant. The pancreas is a gland located behind the stomach that produces hormones and digestive enzymes. Pancreatic neoplasms can interfere with the normal functioning of the pancreas, leading to various health complications.
Benign pancreatic neoplasms are non-cancerous growths that do not spread to other parts of the body. They are usually removed through surgery to prevent any potential complications, such as blocking the bile duct or causing pain.
Malignant pancreatic neoplasms, also known as pancreatic cancer, are cancerous growths that can invade and destroy surrounding tissues and organs. They can also spread (metastasize) to other parts of the body, such as the liver, lungs, or bones. Pancreatic cancer is often aggressive and difficult to treat, with a poor prognosis.
There are several types of pancreatic neoplasms, including adenocarcinomas, neuroendocrine tumors, solid pseudopapillary neoplasms, and cystic neoplasms. The specific type of neoplasm is determined through various diagnostic tests, such as imaging studies, biopsies, and blood tests. Treatment options depend on the type, stage, and location of the neoplasm, as well as the patient's overall health and preferences.
Neoplasms are abnormal growths of cells or tissues in the body that serve no physiological function. They can be benign (non-cancerous) or malignant (cancerous). Benign neoplasms are typically slow growing and do not spread to other parts of the body, while malignant neoplasms are aggressive, invasive, and can metastasize to distant sites.
Neoplasms occur when there is a dysregulation in the normal process of cell division and differentiation, leading to uncontrolled growth and accumulation of cells. This can result from genetic mutations or other factors such as viral infections, environmental exposures, or hormonal imbalances.
Neoplasms can develop in any organ or tissue of the body and can cause various symptoms depending on their size, location, and type. Treatment options for neoplasms include surgery, radiation therapy, chemotherapy, immunotherapy, and targeted therapy, among others.
Neoplasms: Neoplasms refer to abnormal growths of tissue that can be benign (non-cancerous) or malignant (cancerous). They occur when the normal control mechanisms that regulate cell growth and division are disrupted, leading to uncontrolled cell proliferation.
Cystic Neoplasms: Cystic neoplasms are tumors that contain fluid-filled sacs or cysts. These tumors can be benign or malignant and can occur in various organs of the body, including the pancreas, ovary, and liver.
Mucinous Neoplasms: Mucinous neoplasms are a type of cystic neoplasm that is characterized by the production of mucin, a gel-like substance produced by certain types of cells. These tumors can occur in various organs, including the ovary, pancreas, and colon. Mucinous neoplasms can be benign or malignant, and malignant forms are often aggressive and have a poor prognosis.
Serous Neoplasms: Serous neoplasms are another type of cystic neoplasm that is characterized by the production of serous fluid, which is a thin, watery fluid. These tumors commonly occur in the ovary and can be benign or malignant. Malignant serous neoplasms are often aggressive and have a poor prognosis.
In summary, neoplasms refer to abnormal tissue growths that can be benign or malignant. Cystic neoplasms contain fluid-filled sacs and can occur in various organs of the body. Mucinous neoplasms produce a gel-like substance called mucin and can also occur in various organs, while serous neoplasms produce thin, watery fluid and commonly occur in the ovary. Both mucinous and serous neoplasms can be benign or malignant, with malignant forms often being aggressive and having a poor prognosis.
Skin neoplasms refer to abnormal growths or tumors in the skin that can be benign (non-cancerous) or malignant (cancerous). They result from uncontrolled multiplication of skin cells, which can form various types of lesions. These growths may appear as lumps, bumps, sores, patches, or discolored areas on the skin.
Benign skin neoplasms include conditions such as moles, warts, and seborrheic keratoses, while malignant skin neoplasms are primarily classified into melanoma, squamous cell carcinoma, and basal cell carcinoma. These three types of cancerous skin growths are collectively known as non-melanoma skin cancers (NMSCs). Melanoma is the most aggressive and dangerous form of skin cancer, while NMSCs tend to be less invasive but more common.
It's essential to monitor any changes in existing skin lesions or the appearance of new growths and consult a healthcare professional for proper evaluation and treatment if needed.
Multiple primary neoplasms refer to the occurrence of more than one primary malignant tumor in an individual, where each tumor is unrelated to the other and originates from separate cells or organs. This differs from metastatic cancer, where a single malignancy spreads to multiple sites in the body. Multiple primary neoplasms can be synchronous (occurring at the same time) or metachronous (occurring at different times). The risk of developing multiple primary neoplasms increases with age and is associated with certain genetic predispositions, environmental factors, and lifestyle choices such as smoking and alcohol consumption.
Kidney neoplasms refer to abnormal growths or tumors in the kidney tissues that can be benign (non-cancerous) or malignant (cancerous). These growths can originate from various types of kidney cells, including the renal tubules, glomeruli, and the renal pelvis.
Malignant kidney neoplasms are also known as kidney cancers, with renal cell carcinoma being the most common type. Benign kidney neoplasms include renal adenomas, oncocytomas, and angiomyolipomas. While benign neoplasms are generally not life-threatening, they can still cause problems if they grow large enough to compromise kidney function or if they undergo malignant transformation.
Early detection and appropriate management of kidney neoplasms are crucial for improving patient outcomes and overall prognosis. Regular medical check-ups, imaging studies, and urinalysis can help in the early identification of these growths, allowing for timely intervention and treatment.
A "second primary neoplasm" is a distinct, new cancer or malignancy that develops in a person who has already had a previous cancer. It is not a recurrence or metastasis of the original tumor, but rather an independent cancer that arises in a different location or organ system. The development of second primary neoplasms can be influenced by various factors such as genetic predisposition, environmental exposures, and previous treatments like chemotherapy or radiation therapy.
It is important to note that the definition of "second primary neoplasm" may vary slightly depending on the specific source or context. In general medical usage, it refers to a new, separate cancer; however, in some research or clinical settings, there might be more precise criteria for defining and diagnosing second primary neoplasms.
Adenocarcinoma, mucinous is a type of cancer that begins in the glandular cells that line certain organs and produce mucin, a substance that lubricates and protects tissues. This type of cancer is characterized by the presence of abundant pools of mucin within the tumor. It typically develops in organs such as the colon, rectum, lungs, pancreas, and ovaries.
Mucinous adenocarcinomas tend to have a distinct appearance under the microscope, with large pools of mucin pushing aside the cancer cells. They may also have a different clinical behavior compared to other types of adenocarcinomas, such as being more aggressive or having a worse prognosis in some cases.
It is important to note that while a diagnosis of adenocarcinoma, mucinous can be serious, the prognosis and treatment options may vary depending on several factors, including the location of the cancer, the stage at which it was diagnosed, and the individual's overall health.
Thyroid neoplasms refer to abnormal growths or tumors in the thyroid gland, which can be benign (non-cancerous) or malignant (cancerous). These growths can vary in size and may cause a noticeable lump or nodule in the neck. Thyroid neoplasms can also affect the function of the thyroid gland, leading to hormonal imbalances and related symptoms. The exact causes of thyroid neoplasms are not fully understood, but risk factors include radiation exposure, family history, and certain genetic conditions. It is important to note that most thyroid nodules are benign, but a proper medical evaluation is necessary to determine the nature of the growth and develop an appropriate treatment plan.
Myeloproliferative disorders (MPDs) are a group of rare, chronic blood cancers that originate from the abnormal proliferation or growth of one or more types of blood-forming cells in the bone marrow. These disorders result in an overproduction of mature but dysfunctional blood cells, which can lead to serious complications such as blood clots, bleeding, and organ damage.
There are several subtypes of MPDs, including:
1. Chronic Myeloid Leukemia (CML): A disorder characterized by the overproduction of mature granulocytes (a type of white blood cell) in the bone marrow, leading to an increased number of these cells in the blood. CML is caused by a genetic mutation that results in the formation of the BCR-ABL fusion protein, which drives uncontrolled cell growth and division.
2. Polycythemia Vera (PV): A disorder characterized by the overproduction of all three types of blood cells - red blood cells, white blood cells, and platelets - in the bone marrow. This can lead to an increased risk of blood clots, bleeding, and enlargement of the spleen.
3. Essential Thrombocythemia (ET): A disorder characterized by the overproduction of platelets in the bone marrow, leading to an increased risk of blood clots and bleeding.
4. Primary Myelofibrosis (PMF): A disorder characterized by the replacement of normal bone marrow tissue with scar tissue, leading to impaired blood cell production and anemia, enlargement of the spleen, and increased risk of infections and bleeding.
5. Chronic Neutrophilic Leukemia (CNL): A rare disorder characterized by the overproduction of neutrophils (a type of white blood cell) in the bone marrow, leading to an increased number of these cells in the blood. CNL can lead to an increased risk of infections and organ damage.
MPDs are typically treated with a combination of therapies, including chemotherapy, targeted therapy, immunotherapy, and stem cell transplantation. The choice of treatment depends on several factors, including the subtype of MPD, the patient's age and overall health, and the presence of any comorbidities.
The term "DNA, neoplasm" is not a standard medical term or concept. DNA refers to deoxyribonucleic acid, which is the genetic material present in the cells of living organisms. A neoplasm, on the other hand, is a tumor or growth of abnormal tissue that can be benign (non-cancerous) or malignant (cancerous).
In some contexts, "DNA, neoplasm" may refer to genetic alterations found in cancer cells. These genetic changes can include mutations, amplifications, deletions, or rearrangements of DNA sequences that contribute to the development and progression of cancer. Identifying these genetic abnormalities can help doctors diagnose and treat certain types of cancer more effectively.
However, it's important to note that "DNA, neoplasm" is not a term that would typically be used in medical reports or research papers without further clarification. If you have any specific questions about DNA changes in cancer cells or neoplasms, I would recommend consulting with a healthcare professional or conducting further research on the topic.
Lung neoplasms refer to abnormal growths or tumors in the lung tissue. These tumors can be benign (non-cancerous) or malignant (cancerous). Malignant lung neoplasms are further classified into two main types: small cell lung carcinoma and non-small cell lung carcinoma. Lung neoplasms can cause symptoms such as cough, chest pain, shortness of breath, and weight loss. They are often caused by smoking or exposure to secondhand smoke, but can also occur due to genetic factors, radiation exposure, and other environmental carcinogens. Early detection and treatment of lung neoplasms is crucial for improving outcomes and survival rates.
Parotid neoplasms refer to abnormal growths or tumors in the parotid gland, which is the largest of the salivary glands and is located in front of the ear and extends down the neck. These neoplasms can be benign (non-cancerous) or malignant (cancerous).
Benign parotid neoplasms are typically slow-growing, painless masses that may cause facial asymmetry or difficulty in chewing or swallowing if they become large enough to compress surrounding structures. The most common type of benign parotid tumor is a pleomorphic adenoma.
Malignant parotid neoplasms, on the other hand, are more aggressive and can invade nearby tissues and spread to other parts of the body. They may present as rapidly growing masses that are firm or fixed to surrounding structures. Common types of malignant parotid tumors include mucoepidermoid carcinoma, adenoid cystic carcinoma, and squamous cell carcinoma.
The diagnosis of parotid neoplasms typically involves a thorough clinical evaluation, imaging studies such as CT or MRI scans, and fine-needle aspiration biopsy (FNAB) to determine the nature of the tumor. Treatment options depend on the type, size, and location of the neoplasm but may include surgical excision, radiation therapy, and chemotherapy.
Leydig cell hypoplasia
List of MeSH codes (C12)
Meacham syndrome
Precancerous condition
Urethral cancer
Papillary renal cell carcinoma
List of MeSH codes (C04)
Vestibular papillomatosis
Angiofibroma
List of cancer types
List of diseases (P)
Schwannoma
List of skin conditions
Fordyce spots
Verrucous carcinoma
Mammalian kidney
Skin cancer in horses
Bowenoid papulosis
Vulvar cancer
Cutaneous squamous-cell carcinoma
Gynecomastia
Male infertility
Cancer
Bicalutamide
Leydig cell hypoplasia - Wikipedia
Urogenital Squamous Cell Carcinoma: Practice Essentials, Pathophysiology of Penile SCC, Pathophysiology of Prostatic SCC
Use of a modified Vinsot technique for partial phallectomy in 11 standing horses in: Journal of the American Veterinary Medical...
BVS Brasil
US assessment of HPV types in cancers: implications for current and 9-valent HPV vaccines
Mikael Aagaard - Publikationer - Region Hovedstadens forskningsportal
Vol. 9 No. 2 | Research, Society and Development
Epidemiological Study of Penile Cancer in Northeast Brazil
Trends in penile cancer: a comparative study between Australia, England and Wales, and the US<...
Neoplasm staging. Medical search. Definitions
The importance of extranodal extension in penile cancer: a meta-analysis. · NEOMED Bibliography Database
Torbrand, C.<...
College of Osteopathic Medicine - Research output - OSU Center for Health Sciences Research Profiles
Sudhir Isharwal - Publications - Oregon Health & Science University
College of Osteopathic Medicine - Research output - OSU Center for Health Sciences Research Profiles
Division of Hospital Medicine - Research output - Research Profiles at Washington University School of Medicine
Bio2Vec
HuGE Navigator|Genopedia|PHGKB
Detection and typing of human papillomavirus DNA in penile carcinoma: Evidence for multiple independent pathways of penile...
Search Results
Elsa Velazquez | Harvard Catalyst Profiles | Harvard Catalyst
Interleucina-6/genética
Leiomyoma on the shaft of penis - Open Medicine - Volume 5, Issue 5 (2010) - PSJD - Yadda
Urogenital Squamous Cell Carcinoma: Overview, Pathophysiology of Penile SCC, Pathophysiology of Prostatic SCC
Reproductive Pathology - Online Medical Course | Lecturio
TY - BOOK
Excising Penile Syringomas With Scrotal Flap Reconstruction
Penile Lymphoma (Concept Id: C5206640) - MedGen - NCBI
Metastasis3
- They are also defined as penile intraepithelial neoplasia, whereas the abbreviation Tis is used in the tumor-node-metastasis (TNM) classification. (medscape.com)
- Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms . (lookformedical.com)
- The aim of this study was to investigate the importance of ENE in predicting prognosis and presence of pelvic lymph node metastasis (PLNM) in penile cancer patients. (omeka.net)
Carcinoma9
- Among malignant neoplasms of the penis, squamous cell carcinoma (SCC) is the most common. (medscape.com)
- The cause of penile squamous cell carcinoma (SCC) is unclear, although human papillomavirus (HPV) appears to play a major role in many cases. (medscape.com)
- To clarify the role of human papillomavirus (HPV) in penile cancer we evaluated the prevalence of HPV DNA in different histological subtypes of penile carcinoma, dysplasia, and condyloma using a novel, sensitive SPF10 HPV polymerase chain reaction assay and a novel genotyping line probe assay, allowing simultaneous identification of 25 different HPV types. (elsevierpure.com)
- HPV DNA was detected in 42% cases of penile carcinoma, 90% cases of dysplasia, and 100% cases of condyloma. (elsevierpure.com)
- Surgical Approach to a Penile cancer, squamous cell carcinoma, erythroplasia of Queyrat. (bvsalud.org)
- El estudio histopatológico reportó un carcinoma escamoso invasor en la lesión del prepucio y en la piel del glande, con todos los márgenes quirúrgicos, limites laterales y profundos, negativos a malignidad. (bvsalud.org)
- Conclusion Regardless of tumor subtypes, penile carcinoma in Northeastern Brazil had more aggressive features and behavior when presented at younger age. (fiocruz.br)
- In 1948, Lauren V. Ackermann first described this neoplasm of the oral mucous membrane, which is now also know as Verrucous Carcinoma of Ackermann or Ackermann's tumor. (ispub.com)
- Whether the carcinoma occur in the upper aerodigestive tract (verrucous carcinoma), on the genitalia (condyloma acuminatum), or on extremities (carcinoma cuniculatum), they are essentially the same neoplasm with slow growing, locally invasive and nonmetastasizing behavior 3 . (ispub.com)
Colorectal Neoplasms1
- Patients who did not undergo full colonoscopy preoperatively should undergo colonoscopy within 3-6 months postoperatively to exclude other synchronous colorectal neoplasms and 1 year thereafter. (health.am)
Cancer30
- HPV DNA was detected in 90.6% of cervical, 91.1% of anal, 75.0% of vaginal, 70.1% of oropharyngeal, 68.8% of vulvar, 63.3% of penile, 32.0% of oral cavity, and 20.9% of laryngeal cancers, as well as in 98.8% of cervical cancer in situ (CCIS). (nih.gov)
- To trace the clinical and epidemiological profile of penile cancer in Rio Grande do Norte/Brazil and relate them to data published in the literature. (clinmedjournals.org)
- A retrospective cohort study was conducted with 94 patients diagnosed with penile cancer in 2011-2018, treated at the Liga Norte Riograndense Contra o Cancer. (clinmedjournals.org)
- The State of Rio Grande do Norte has a high incidence of penile cancer with a high frequency of locally advanced tumors at diagnosis and in younger patients younger than 50. (clinmedjournals.org)
- Penile cancer is a rare neoplasm in the United States and Europe, accounting for less than 1% of cancers in men. (clinmedjournals.org)
- Brazil is one of the countries with the highest incidence of penile cancer in the world [ 5 , 6 ] which may correspond to 2.1% of all neoplasms in men, being five times more prevalent in the North and Northeast regions [ 7 ], where most of the procedures are performed. (clinmedjournals.org)
- Among these regions, Brazilian studies indicate that the State of Maranhão (Northeast of Brazil) has the highest incidence of penile cancer in Brazil, with an age-standardized incidence of 6.15 cases/100,000 habitants, with approximate statistics of one new case every 17 days [ 6 ]. (clinmedjournals.org)
- Penile cancer is an aggressive and mutilating disease that affects self-esteem, with psychological and functional repercussions, which make rehabilitation and social reintegration difficult [ 7 ]. (clinmedjournals.org)
- Therefore, the Brazilian Penile Cancer Consensus argues that reducing the incidence of this cancer is possible by encouraging intimate hygiene education, neonatal circumcision, smoking cessation, vaccination against HPV among young people, and the use of condoms [ 4 ]. (clinmedjournals.org)
- Purpose: To investigate and compare the trends in incidence and mortality of penile cancer between Australia, England and Wales, and the US, and provide hypotheses for these trends. (ukhsa.gov.uk)
- Results: The overall incidence of penile cancer in England and Wales (1.44 per 100,000 man-years) was higher than in Australia (0.80 per 100,000), and the US (0.66 per 100,000). (ukhsa.gov.uk)
- Incidence of penile cancer in all three countries has remained relatively stable over time. (ukhsa.gov.uk)
- Conclusions: Penile cancer incidence is low, affecting mainly older men. (ukhsa.gov.uk)
- The importance of extranodal extension in penile cancer: a meta-analysis. (omeka.net)
- BACKGROUND: The role of extranodal extension (ENE) in penile cancer is controversial and has not been well studied. (omeka.net)
- Further subgroup analysis revealed that the predictive value of ENE for CSS in penile cancer patients was significant regardless of the study's country of origin, but not in the subgroup with shorter follow-up time (\textless36 months, P = 0.38). (omeka.net)
- CONCLUSIONS: ENE is associated with worse prognosis and high risk of PLNM in penile cancer patients. (omeka.net)
- Zhou Fang-Jian, "The importance of extranodal extension in penile cancer: a meta-analysis. (omeka.net)
- In addition, specific histological subtypes of penile cancer - basaloid and warty - are consistently associated with HPV, however, only a subset of keratinizing and verrucous penile carcinomas is positive for HPV DNA, and thus these two tumor groups seem to develop along different pathogenetic pathways. (elsevierpure.com)
- Penile cancer: a local case series and literature review. (nih.gov)
- Paiva GR Penile cancer. (fiocruz.br)
- Purpose In order to describe epidemiological and pathological features of penile cancer in a high-risk area of Brazil. (fiocruz.br)
- Methods We reviewed the experience (378 patients from 1997 to 2007) of Hospital Aristides Maltez from Salvador, Bahia-the main institution in the state which provides oncologic treatment for penile cancer in the public health system. (fiocruz.br)
- Penile cancer risks can be increased by a number of causes such as smoking, phimosis, poor hygiene, multiple sexual partners and history of gential warts or other sexually transmitted diseases. (uk.com)
- This year the congress will be broadcast online, and will present modules such as Kidney, Prostate, Penile and Bladder Cancer, bringing important national and international experts to discuss relevant topics in these areas. (lacogcancerresearch.org)
- Cancer uterine icd 10 ICDCM BootCamp: Neoplasms retete pt detoxifiere Un vierme mic costache ioanid smoothie verde detoxifiant retete, rectal cancer x ray toxine botulique rat. (wishstudio.ro)
- ICD - 10 Guidelines - Chapter 2 Neoplasms C00 D49 - class 1 - Medical Coding Guidelines enemas de la viermi la copii Papiloma virus cancer garganta preparate pentru tratarea helmintelor umane, endometrial cancer icd 10 papilloma gola ciuperci de plop. (wishstudio.ro)
- Medical Coding of Neoplasms: Part 1 rectal cancer uk statistics Definition for toxine rectal cancer journal articles, squamous vestibular papillomatosis cancerul pancreasului endocrin. (wishstudio.ro)
- ICDCM Coding Demonstration using Neoplasm Table cancerul gastric-intestinal Profilaxie helminti case laryngeal papilloma, papillomavirus homme oeil kako se leci hpv Condylomata acuminata definition hpv cervical cancer leep, papilloma virus e ciclo mestruale papilloma squamous eyelid. (wishstudio.ro)
- Kirrander P, Sherif A, Friedrich B, Lambe M, Hakansson U, steering committee of the Swedish National Penile Cancer R. The Swedish National Penile Cancer Register: Incidence, Tumour Characteristics, Management and Survival. (cancercentrum.se)
Vaginal1
- A vaccine targeting HPV 16/18 potentially prevents the majority of invasive cervical (66.2%), anal (79.4%), oropharyngeal (60.2%), and vaginal (55.1%) cancers, as well as many penile (47.9%), vulvar (48.6%) cancers: 24 858 cases annually. (nih.gov)
Cases of penile1
- A systematic review by Ribera-Cortada et al in 2021 noted that the most common mutations in cases of penile SCC involved the genes TP53 , CDKN2A , FAT1 , NOTCH-1 , and PIK3CA . (medscape.com)
Malignant3
- SCC of the prostate is a rare malignant epithelial neoplasm arising in the prostate, with squamous differentiation of the neoplastic cells. (medscape.com)
- This rare pathologic finding, which usually mimics a malignant lesion, should be included in the differential diagnosis of penile neoplasm. (edu.pl)
- In 1896, Buschke, and subsequently in 1925, Buschke and Loewenstein, described a penile lesion which appeared benign cytologically, yet which behaved in a malignant fashion. (ispub.com)
Ureteral Neoplasms3
- Ureteral Neoplasms" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
- This graph shows the total number of publications written about "Ureteral Neoplasms" by people in UAMS Profiles by year, and whether "Ureteral Neoplasms" was a major or minor topic of these publications. (uams.edu)
- Below are the most recent publications written about "Ureteral Neoplasms" by people in Profiles over the past ten years. (uams.edu)
Tumors1
- Penile tumors present a difficult diagnostic and therapeutic issue, mainly because of their psychological implications. (medscape.com)
Excision2
- We report the excision and reconstruction of multiple synchronous penile shaft syringomas with local scrotal flaps. (medscape.com)
- We report a rare case of excision of multiple penile syringomas and reconstruction with scrotal flaps in a 29-year-old man. (medscape.com)
Hematologic Neoplasms1
- All types of hematologic neoplasms have been previously reported, although CML has been rarely encountered. (amjcaserep.com)
Sarcoma2
- Kaposi sarcoma is a vascular neoplasm composed of endothelium-lined vascular spaces and spindle-shaped cells. (bvsalud.org)
- Kaposi's sarcoma is a neoplasm of vascular endothelium that is characterized by proliferation of spindle cells, neoangiogenesis, inflammation and edema 17 . (bvsalud.org)
Diagnosis3
- Local penile factors and systemic diseases, including diabetes, cardiac disease, and neurologic disorders, can cause ED. Diagnosis is via physical exam and history. (lecturio.com)
- There was evident dysgranulopoiesis that raised a provisional diagnosis of myelodysplastic/myeloproliferative neoplasm. (amjcaserep.com)
- Annually, the scientific program is developed with the most actual in the treatment and diagnosis of genitourinary neoplasms. (lacogcancerresearch.org)
Treatment of penile1
- The treatment of penile SCC varies according to the clinical stage. (medscape.com)
Surgical1
- Invasive surgical penile implants may be considered when conservative measures fail. (lecturio.com)
Pathology1
- Ki-67 assessment of pancreatic neuroendocrine neoplasms: Systematic review and meta-analysis of manual vs. digital pathology scoring. (who.int)
Penis3
- Despite being a complex surgery, studies show that penile reconstruction (phalloplasty) is possible after penectomy when the functional length of the Penis is inadequate for a man to urinate standing up or have sexual intercourse [ 8 - 10 ]. (clinmedjournals.org)
- An isolated penile mass in a young adult turned out to be a primary marginal zone lymphoma of the penis. (nih.gov)
- A 64-year-old male patient presented with a soft, cystic, large subcutaneous mass on the right ventral side of the penis, located in the distal half of the penile shaft, causing distortion, with no underlying disease. (jwmr.org)
Different histological1
- The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. (lookformedical.com)
48.61
- Kim et al found mutations of TERT-p in 18 out of 37 (48.6%) penile SCCs, including all 3 of the in situ cases. (medscape.com)
Lymphoma4
- Diffuse large B-cell lymphoma is the most common primary penile lymphoma. (nih.gov)
- Primary penile lymphoma: the use of PET-CT for accurate staging and response monitoring. (nih.gov)
- Primary penile lymphoma: diagnostic difficulties and management options. (nih.gov)
- Primary penile lymphoma presenting as a penile ulcer. (nih.gov)
Primary1
- Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system. (lookformedical.com)
Circumcision1
- Other associations considered to play a role in the development of penile SCC include pre-existing dermatoses, lack of circumcision, and other factors, including environmental exposures. (medscape.com)
Lesion1
- A A 52-year-old male patient presented to the urology office with a two-year history of noticing a Abordaje quirúrgico bright red, pruritic, and painful lesion on the glans and foreskin with a progressive increase in size that did not improve with primario en un paciente antibiotic and antifungal treatments. (bvsalud.org)
Pathways1
- The authors also noted that Hippo, Notch, and RTK-RAS pathways are often deregulated in penile SCC patients. (medscape.com)
Squamous cell carc9
- Penile squamous cell carcinoma (PSCC) is rare with limited treatment options. (nih.gov)
- 6. Limitations in the interpretation of biopsies in patients with penile squamous cell carcinoma. (nih.gov)
- Among malignant neoplasms of the penis, squamous cell carcinoma (SCC) is the most common. (medscape.com)
- The cause of penile squamous cell carcinoma (SCC) is unclear, although human papillomavirus (HPV) appears to play a major role in many cases. (medscape.com)
- Development of a new outcome prediction model for Chinese patients with penile squamous cell carcinoma based on preoperative serum C-reactive protein, body. (oncotarget.com)
- Purpose: To determine the predictive value and feasibility of the new outcome prediction model for Chinese patients with penile squamous cell carcinoma. (oncotarget.com)
- Basaloid and warty subtypes of penile squamous cell carcinoma are most frequently associated with HPV infection. (chennaicircumcisionclinic.in)
- Surgical Approach to a Penile cancer, squamous cell carcinoma, erythroplasia of Queyrat. (bvsalud.org)
- A clinical suspicion of an invasive squamous cell carcinoma was made and the patient underwent a wide local excision of the penile and satellite lesions. (biomedcentral.com)
Penis1
- 12. Sarcomatoid Carcinoma of the Penis: An Uncommon Penile Neoplasm. (nih.gov)
Cancers1
- In fact, HPV is found in about half of all penile cancers. (chennaicircumcisionclinic.in)
Skin Neoplasms1
- Radiation Induced Multiple Skin Neoplasms Following Craniospinal Irradiation for Medulloblastoma. (amjcaserep.com)
Connective Tissue4
- Neoplasms, Connective Tissue" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
- The concept does not refer to neoplasms located in connective tissue. (jefferson.edu)
- This graph shows the total number of publications written about "Neoplasms, Connective Tissue" by people in this website by year, and whether "Neoplasms, Connective Tissue" was a major or minor topic of these publications. (jefferson.edu)
- Below are the most recent publications written about "Neoplasms, Connective Tissue" by people in Profiles. (jefferson.edu)
Epithelial2
- SCC of the prostate is a rare malignant epithelial neoplasm arising in the prostate, with squamous differentiation of the neoplastic cells. (medscape.com)
- An extremely rare penile epithelial neoplasm, histologically composed of nests of epithelial cells floating in lakes of extracellular, PAS-positive mucin, with clinical characteristics of a nonhealing ulcer or soft mass in the preputium or glans area, with itching and burning often preceding appearance of the lesion. (cdc.gov)
Intraepithelial neoplasia1
- Objectives: To analyse the incidence, treatment strategies and complications associated with penile intraepithelial neoplasia (PeIN) in Sweden over a period of 20 years. (lu.se)
Malignancies1
- Recurrent inflammation of the prenuptial skin linked to penile malignancies is attributed to the presence of phimosis. (chennaicircumcisionclinic.in)
Lesions2
- Zeiger, Roni F.. "Penile Papules & Other Lesions. (unboundmedicine.com)
- Medicine Central , im.unboundmedicine.com/medicine/view/Diagnosaurus/115000/all/Penile_papules_&_other_lesions. (unboundmedicine.com)
Foreskin2
- Phimosis being a structural inability of a tight foreskin that cannot be retracted, when left untreated can lead to secondary complications that increase the susceptibility for penile carcinoma. (chennaicircumcisionclinic.in)
- A A 52-year-old male patient presented to the urology office with a two-year history of noticing a Abordaje quirúrgico bright red, pruritic, and painful lesion on the glans and foreskin with a progressive increase in size that did not improve with primario en un paciente antibiotic and antifungal treatments. (bvsalud.org)
Dermatoses1
- Other associations considered to play a role in the development of penile SCC include pre-existing dermatoses, lack of circumcision, and other factors, including environmental exposures. (medscape.com)
Disease3
- Whole-body computed tomography (CT) scan often reveals disseminated neoplastic disease, which is the cause of high mortality in secondary penile neoplasms. (bvsalud.org)
- We determined whether SWE values are correlated with the degree of penile curvature, the time of disease onset, and pain severity experienced by patients during erection. (researchgate.net)
- An 87-year-old Caucasian male was referred to our centre by a dermatologist, having undergone punch biopsy of a penile lesion with the initial histology reported as showing Bowen's disease. (biomedcentral.com)
Situ1
- Kim et al found mutations of TERT-p in 18 out of 37 (48.6%) penile SCCs, including all 3 of the in situ cases. (medscape.com)
Tissues1
- PSCC and matched normal penile tissues from 34 prospectively followed patients, underwent genomic WES and human papilloma virus testing. (nih.gov)
Disorder1
- It is both a physically and psychologically devastating disorder that causes penile deformity, curvature, narrowing and shortening, which eventually compromise sexual function. (researchgate.net)
Rare1
- We also review the literature and highlight the need for a high index of suspicion in the diagnosis of this rare neoplasm. (biomedcentral.com)
Patients1
- The authors also noted that Hippo, Notch, and RTK-RAS pathways are often deregulated in penile SCC patients. (medscape.com)