Peptic Ulcer Hemorrhage
Peptic Ulcer
Peptic Ulcer Perforation
Endoscopic retreatment compared with surgery in patients with recurrent bleeding after initial endoscopic control of bleeding ulcers. (1/305)
BACKGROUND AND METHODS: After endoscopic treatment to control bleeding of peptic ulcers, bleeding recurs in 15 to 20 percent of patients. In a prospective, randomized study, we compared endoscopic retreatment with surgery after initial endoscopy. Over a 40-month period, 1169 of 3473 adults who were admitted to our hospital with bleeding peptic ulcers underwent endoscopy to reestablish hemostasis. Of 100 patients with recurrent bleeding, 7 patients with cancer and 1 patient with cardiac arrest were excluded from the study; 48 patients were randomly assigned to undergo immediate endoscopic retreatment and 44 were assigned to undergo surgery. The type of operation used was left to the surgeon. Bleeding was considered to have recurred in the event of any one of the following: vomiting of fresh blood, hypotension and melena, or a requirement for more than four units of blood in the 72-hour period after endoscopic treatment. RESULTS: Of the 48 patients who were assigned to endoscopic retreatment, 35 had long-term control of bleeding. Thirteen underwent salvage surgery, 11 because retreatment failed and 2 because of perforations resulting from thermocoagulation. Five patients in the endoscopy group died within 30 days, as compared with eight patients in the surgery group (P=0.37). Seven patients in the endoscopy group (including 6 who underwent salvage surgery) had complications, as compared with 16 in the surgery group (P=0.03). The duration of hospitalization, the need for hospitalization in the intensive care unit and the resultant duration of that stay, and the number of blood transfusions were similar in the two groups. In multivariate analysis, hypotension at randomization (P=0.01) and an ulcer size of at least 2 cm (P=0.03) were independent factors predictive of the failure of endoscopic retreatment. CONCLUSIONS: In patients with peptic ulcers and recurrent bleeding after initial endoscopic control of bleeding, endoscopic retreatment reduces the need for surgery without increasing the risk of death and is associated with fewer complications than is surgery. (+info)Prevalence and cost of hospitalization for gastrointestinal complications related to peptic ulcers with bleeding or perforation: comparison of two national databases. (2/305)
The purpose of this study was to determine the prevalence and cost of hospitalization for upper gastrointestinal complications, including peptic ulcers with hemorrhage or perforation. Upper gastrointestinal complications and corresponding economic data were obtained from two sources. The first was a 20% sample of all community hospital discharges (about 6 million per year) from 11 states for 1991 and 1992 Hospital Cost Utilization Project; HCUP-3). The second source of data was a claims database for employees of large US corporations and their dependents for 1992, 1993, and 1994 (about 3.5 million covered lives per year; MarketScan). A group of ICD-9 codes for the diagnosis of peptic and gastroduodenal ulcers with bleeding or perforation were used to identify hospital admissions because of upper gastrointestinal complications. Similar patterns were observed across the MarketScan and HCUP-3 databases regarding hospitalization with diagnoses related to gastrointestinal complications identified according to the ICD-9 codes. The average age of patients with upper gastrointestinal complications was 66 years in the HCUP-3 database and 52 years in the MarketScan database. The average annual rates of upper gastrointestinal complications as a primary or secondary diagnosis were 6.4 and 6.7 per 1000 discharges for 1991 and 1992, respectively (HCUP-3), and 4.3, 4.2, and 4.9 per 1000 admissions for 1992, 1993, and 1994, respectively (MarketScan). The average length of stay for upper gastrointestinal complications as a primary diagnosis was 7.8 days in 1991 and 7.5 days in 1992 (HCUP-3) and 6.1, 5.1, and 5.1 days in 1992, 1993, and 1994, respectively (MarketScan). The national average total charge for hospitalization for gastrointestinal problems as a primary diagnosis was $12,970 in 1991 and $14,294 in 1992 (HCUP-3). The average total reimbursement for hospitalizations related to upper gastrointestinal problems was $15,309 in 1992, $12,987 in 1993, and $13,150 in 1994 (MarketScan). Hospital admissions for upper gastrointestinal complications are expensive. The rate and cost per admission are higher for the older population. The results on the elements covered by both databases are consistent. Therefore the databases complement each other on the type of information abstracted. (+info)Comparison of adrenaline injection and bipolar electrocoagulation for the arrest of peptic ulcer bleeding. (3/305)
BACKGROUND: Peptic ulcers with active bleeding or a non-bleeding visible vessel require aggressive endoscopic treatment. AIMS: To determine whether endoscopic adrenaline injection alone or contact probe therapy following injection is a suitable treatment for peptic ulcer bleeding. METHODS: A total of 96 patients with active bleeding or non-bleeding visible vessels received adrenaline alone, bipolar electrocoagulation alone, or combined treatment (n=32 in each group). RESULTS: Initial haemostasis was not achieved in one patient in the adrenaline group, two in the gold probe group, and two in the injection gold probe group (p>0.1). Rebleeding episodes were fewer in the injection gold probe group (2/30, 6.7%) than in the gold probe group (9/30, 30%, p=0.04) and in the adrenaline group (11/31, 35.5%, p=0.01). Treatment failure (other therapy required) was rarer in the injection gold probe group (4/32, 12.5%) than in the adrenaline group (12/32, 37.5%, p=0.04). The volume of blood transfused after entry of the study was less in the injection gold probe group (mean 491 ml) than in the adrenaline group (1548 ml, p<0. 0001) and the gold probe group (1105 ml, p<0.01). Duration of hospital stay, numbers of patients requiring urgent surgery, and death rate were not statistically different among the three groups. CONCLUSIONS: For patients with peptic ulcer bleeding, combined adrenaline injection and gold probe treatment offers an advantage in preventing rebleeding and decreasing the need for blood transfusion. (+info)Helicobacter pylori infection is a protective factor for bleeding gastric ulcers but not for bleeding duodenal ulcers in NSAID users. (4/305)
BACKGROUND: The effect of Helicobacter pylori infection on NSAID-induced gastroduodenal damage is unclear. AIM: To determine the role of H. pylori and NSAID use in complicated peptic ulcers. METHODS: A total of 185 consecutive patients with bleeding peptic ulcers and 185 hospitalized matched controls were studied prospectively. Additionally, 75 consecutive uncomplicated peptic ulcers and 75 community controls were also studied. Active H. pylori infection was determined by urea breath test and/or both urease test and histology. Serum CagA and VacA status were determined at random in 135 infected patients and 82 controls. NSAID use was determined by structured data collection. RESULTS: H. pylori (odds ratio [OR]=5. 98; 2.9-12.3) and NSAID use (OR=5.74; 3.4-9.7) were independent risk factors for duodenal ulcer bleeding, whereas NSAID use was the main risk factor for bleeding gastric ulcers (OR=12.4; 5.5-27.9). Interaction of both factors was associated with reduced risk for bleeding gastric ulcers (OR=0.19; 0.04-0.88) but not for bleeding duodenal ulcers, which showed a similar risk to any one factor alone. This was observed for all types of NSAID use, including low-dose aspirin, and infection by CagA positive strains. H. pylori was the only factor involved in common uncomplicated duodenal ulcers. CONCLUSION: Interaction of both H. pylori infection and NSAID use decreases the risk of bleeding due to gastric ulcers, but not that due to duodenal ulcers. (+info)Peptic ulcer bleeding: accessory risk factors and interactions with non-steroidal anti-inflammatory drugs. (5/305)
AIMS: To determine risk factors for peptic ulcer bleeding other than non-steroidal anti-inflammatory drugs (NSAIDs). Methods-Data on possible antecedent risk factors obtained in a large case control study of 1121 patients admitted to hospitals in Glasgow, Newcastle, Nottingham, Oxford, and Portsmouth with bleeding peptic ulcers were compared with the same information obtained in 989 population controls. Data were analysed by logistic regression with the calculation of odds ratios (OR) and 95% confidence intervals (CI). RESULTS: From a logistic regression model, oral anticoagulants (OR 7. 8; 95% CI 2.8-21.5), previous peptic ulcer (3.8; 2.6-4.9), treatment for heart failure (5.9; 2.3-13.1), oral corticosteroid use (2.7; 1. 3-4.5), treatment for diabetes (3.1; 1.2-4.3), and current smoking (1.6; 1.2-2.0) were all independent risk factors. No association was found with use of calcium channel antagonists. Odds ratios for concomitant NSAID usage were multiplicative with the exception of current smoking. CONCLUSIONS: Some 45% of admissions for peptic ulcer bleeding in England and Wales in those aged 60 or more are calculated to be attributable to, or associated with, these accessory risk factors, which, together with those associated with aspirin or other NSAID use will account for over 80% of predisposing factors to ulcer bleeding. (+info)Risk of ulcer bleeding in patients infected with Helicobacter pylori taking non-steroidal anti-inflammatory drugs. (6/305)
OBJECTIVE: To determine whether Helicobacter pylori is an independent risk factor for bleeding peptic ulcer in users of non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin. DESIGN: A prospective matched case-control study. SETTING: Odense University Hospital, Denmark. SUBJECTS: 132 patients with a bleeding peptic ulcer (n=124) or haemorrhagic gastritis (n=8) at endoscopy who had taken an NSAID in the previous week and 136 controls who had taken NSAIDs without gastrointestinal complications. The controls were recruited from rheumatology and geriatric outpatient clinics. MEASUREMENTS: H pylori status assessed by serology and 13C-urea breath test and regarded as positive if either test was positive. Data on potential confounding factors including smoking and alcohol were collected by interview. MAIN RESULT: H pylori was present in 57% of cases and 43% of controls. The adjusted odds ratio of bleeding from a peptic ulcer owing to H pylori infection in NSAID users was 1.81 (95% CI 1.02 to 3.21) and was similar in aspirin and non-aspirin NSAID users. Peptic ulcer bleeding was also statistically significantly associated with a history of previous ulcer bleeding, dyspepsia within the previous 3 months, drinking alcohol but not with smoking. About 16% of bleeding peptic ulcers in NSAID users could be attributed to H pylori infection. CONCLUSION: NSAID users infected with H pylori have an almost doubled risk of bleeding peptic ulcer compared with uninfected NSAID users. (+info)Low sensitivity of invasive tests for the detection of Helicobacter pylori infection in patients with bleeding ulcer. (7/305)
BACKGROUND: A high false negative rate for antral infection with Helicobacter pylori when assessed by rapid urease test has recently been reported in patients with bleeding ulcer. This result could partly explain the differing prevalence of H. pylori infection in bleeding and non-bleeding ulcers. AIMS: To evaluate the accuracy of a rapid urease test (UT), histology and culture for detection of H. pylori in antral biopsies from acute bleeding peptic ulcer patients using a serological test as reference. PATIENTS AND METHODS: All consecutive patients with active bleeding gastric or duodenal ulcer at endoscopic examination admitted in six university hospitals in France were considered for inclusion. Five antral biopsies were taken during the diagnostic endoscopy for UT, culture and histology. A blood sample was taken for H. pylori serology. RESULTS: One hundred and eighty one patients were included and 129 (71%) had a positive serology. The sensitivity of UT, histology and culture for detection of H. pylori infection were 41%, 33% and 34%, respectively. The sensitivity and specificity of the combination of the three invasive tests were 48.8% (95% CI: 40.2-57.4) and 90.6% (95% CI: 82. 6-99) respectively. In the 52 serologically negative patients, only 5 had at least one invasive positive test. The sensitivity of the invasive tests decreased significantly with age but was not influenced by NSAIDs intake. Of 80 patients with a positive serological test and negative histological evaluation for H. pylori, chronic antral inflammation was found in 70 patients (87%). In 46 patients with both negative serological test and H. pylori negative test according to histology, only 13 (28%) had chronic antral inflammation. CONCLUSIONS: The sensitivity of invasive tests for detection of H. pylori is low during acute ulcer bleeding, and they should be used with caution in this condition. A serological test is recommended to identify patients with H. pylori infection in spite of negative invasive tests. (+info)Overall mortality among patients surviving an episode of peptic ulcer bleeding. (8/305)
STUDY OBJECTIVE: The authors investigated whether patients who have survived an acute episode of peptic ulcer bleeding (PUB) have an excess long term all cause mortality compared with the general population free of PUB. DESIGN: Follow up study of previously identified cohort of patients with a PUB episode and a general population cohort. SETTING: The source population included all people aged 30 to 89 years, registered with general practitioners in the United Kingdom. PATIENTS: All patients alive one month after the PUB episode constituted the cohort of PUB patients (n = 978). A control group of 5000 people was randomly sampled from the source population. The same eligibility criteria as for patients with PUB were applied to the control series. Also, controls had to be free of PUB before start date. MAIN RESULTS: Relative risk of mortality among PUB patients was 2.1, 95% CI: 1.7, 2.6) compared with the general population. This increased mortality risk occurred mainly in the patients less than 60 years old. No difference was observed between men and women. The excess mortality was not only circumscribed to deaths attributable to recurrent gastrointestinal bleed, but also cardiovascular, cancer and other causes. CONCLUSIONS: People who have survived an acute episode of PUB have a reduced long term survival compared with the general population. This reduction was stronger among middle age patients than in the elderly. (+info)Peptic ulcer hemorrhage is a medical condition characterized by bleeding in the gastrointestinal tract due to a peptic ulcer. Peptic ulcers are open sores that develop on the lining of the stomach, lower esophagus, or small intestine. They are usually caused by infection with the bacterium Helicobacter pylori or long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs).
When a peptic ulcer bleeds, it can cause symptoms such as vomiting blood or passing black, tarry stools. In severe cases, the bleeding can lead to shock, which is a life-threatening condition characterized by a rapid heartbeat, low blood pressure, and confusion. Peptic ulcer hemorrhage is a serious medical emergency that requires immediate treatment. Treatment may include medications to reduce stomach acid, antibiotics to eliminate H. pylori infection, and endoscopic procedures to stop the bleeding. In some cases, surgery may be necessary to repair the ulcer or remove damaged tissue.
A peptic ulcer is a sore or erosion in the lining of your stomach and the first part of your small intestine (duodenum). The most common causes of peptic ulcers are bacterial infection and long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen, or naproxen.
The symptoms of a peptic ulcer include abdominal pain, often in the upper middle part of your abdomen, which can be dull, sharp, or burning and may come and go for several days or weeks. Other symptoms can include bloating, burping, heartburn, nausea, vomiting, loss of appetite, and weight loss. Severe ulcers can cause bleeding in the digestive tract, which can lead to anemia, black stools, or vomit that looks like coffee grounds.
If left untreated, peptic ulcers can result in serious complications such as perforation (a hole through the wall of the stomach or duodenum), obstruction (blockage of the digestive tract), and bleeding. Treatment for peptic ulcers typically involves medications to reduce acid production, neutralize stomach acid, and kill the bacteria causing the infection. In severe cases, surgery may be required.
Peptic ulcer perforation is a serious and sightful gastrointestinal complication characterized by the penetration or erosion of an acid-peptic ulcer through the full thickness of the stomach or duodenal wall, resulting in spillage of gastric or duodenal contents into the peritoneal cavity. This leads to chemical irritation and/or bacterial infection of the abdominal cavity, causing symptoms such as sudden severe abdominal pain, tenderness, rigidity, and potentially life-threatening sepsis if not promptly diagnosed and treated with surgical intervention, antibiotics, and supportive care.
A stomach ulcer, also known as a gastric ulcer, is a sore that forms in the lining of the stomach. It's caused by a breakdown in the mucous layer that protects the stomach from digestive juices, allowing acid to come into contact with the stomach lining and cause an ulcer. The most common causes are bacterial infection (usually by Helicobacter pylori) and long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs). Stomach ulcers may cause symptoms such as abdominal pain, bloating, heartburn, and nausea. If left untreated, they can lead to more serious complications like internal bleeding, perforation, or obstruction.
Astringent
Billy Tipton
Weekend effect
Danny Polo
Valentino's syndrome
Peptic ulcer disease
Abdul Latif Sharif
Charles Illingworth
Antrectomy
Maksim Fridman
Melena
List of MeSH codes (C23)
Prasugrel
Abdominal pain
Thrombosis prevention
Hypovolemic shock
Gastroduodenal artery
Mast cell leukemia
Paolo Orano
Stress-related disorders
Therapeutic endoscopy
Forrest classification
Perforated ulcer
Dieulafoy's lesion
Abdominal guarding
Gastrointestinal bleeding
Hemosuccus pancreaticus
Harrison's Principles of Internal Medicine
Acute pancreatitis
Streptokinase
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Perforation6
- Severe abdominal pain with or without evidence of bleeding may indicate a perforation of the ulcer through the stomach or duodenum. (mountsinai.org)
- A these infections prevents recurrence and ulcer complica- recent meta-analysis in which researchers adjusted for age tions such as bleeding or perforation ( 4-6 ). (cdc.gov)
- RESULTS: A total of 3611 patients undergoing emergency ulcer surgery (775 for bleeding, 2374 for perforation) were included for data analysis. (duke.edu)
- Compared with patients undergoing local procedures alone, vagotomy/gastric resection was associated with significantly greater postoperative morbidity when performed for either ulcer perforation or bleeding. (duke.edu)
- Peptic ulcer perforation occurred more frequently after Ramadan but the difference was not significant. (who.int)
- Patients with perforation of peptic been reported, such as decreased daytime ulcer that occurred outside the 2 months of oral temperature, alertness, mood, re- study were excluded. (who.int)
Nonsteroidal anti-3
- Peptic ulcers can result from infection with Helicobacter pylori bacteria or from use of medications, such as aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs), that weaken the lining of the stomach or duodenum. (merckmanuals.com)
- Taking certain pain relief medications known as nonsteroidal anti-inflammatory drugs (NSAIDs) at high doses or for extended periods can cause peptic or bleeding ulcers. (medicalnewstoday.com)
- Certain drugs, such as aspirin and other nonsteroidal anti-inflammatory drugs, reserpine, and possibly corticosteroids may initiate the formation of an ulcer. (rawfoodexplained.com)
Complications4
- Infection with Helicobacter pylori increases the risk for decline in hospitalizations for PUD and its complications peptic ulcer disease (PUD) and its complications. (cdc.gov)
- Thrombosis is the most common cause of death, followed by the complications of myeloid metaplasia and hemorrhage. (fundacionmapfre.org)
- Cigarette smoking is a risk factor for the development of ulcers and their complications. (msdmanuals.com)
- L'analyse des données triennales met en évidence une baisse importante de la mortalité par hémorragie et par complications de l'anesthésie. (bvsalud.org)
Disease27
- There are many possible causes of GI bleeding, including hemorrhoids, peptic ulcers, tears or inflammation in the esophagus, diverticulosis and diverticulitis, ulcerative colitis and Crohn's disease, colonic polyps, or cancer in the colon, stomach or esophagus. (icdlist.com)
- The aim of this study was to determine the presentation, treatment, and outcome of children requiring surgery for peptic ulcer disease (PUD) in the post-histamine 2 -blocker era. (nih.gov)
- Three (10%) children required reoperation for persistent or recurrent ulcer disease and 4 children died. (nih.gov)
- The underlying mechanisms of nonvariceal bleeding involve either arterial hemorrhage, such as in ulcer disease and mucosal deep tears, or low-pressure venous hemorrhage, as in telangiectasias and angioectasias. (medscape.com)
- The diagnosis of peptic ulcer disease is based on symptoms of stomach pain and on the results of an examination of the stomach with a flexible viewing tube (upper endoscopy) and of Helicobacter pylori testing. (merckmanuals.com)
- Introduction to Gastritis and Peptic Ulcer Disease Gastritis and peptic ulcer disease involve damage to the lining of the stomach or duodenum (the first segment of the small intestine). (merckmanuals.com)
- stomach inflammation) may develop into ulcer disease. (merckmanuals.com)
- Doctors found a higher incidence of ulcer disease in Japan after an earthquake and in New York after the terrorist attacks of 9/11. (merckmanuals.com)
- Hospitalizations for Peptic Ulcer Disease was signifi cantly associated with male sex in 18 adult pop- gastric, gastrojejunal, and duodenal), other diagnoses list- ulations ( 14 ). (cdc.gov)
- Helicobacter pylori Infection Helicobacter pylori is a common gastric pathogen that causes gastritis, peptic ulcer disease, gastric adenocarcinoma, and low-grade gastric lymphoma. (msdmanuals.com)
- If H. pylori is eradicated, only 10% of patients have recurrence of peptic ulcer disease, compared with 70% recurrence in patients treated with acid suppression alone. (msdmanuals.com)
- METHODS: A retrospective analysis of data for patients from the 2005-2011 American College of Surgeons National Surgical Quality Improvement Program database who underwent emergency operation for bleeding or perforated peptic ulcer disease was performed to determine the association between surgical approach (local procedure alone, vagotomy/drainage, or vagotomy/gastric resection) and 30-day postoperative outcomes. (duke.edu)
- CONCLUSIONS: Simple repair is the procedure of choice for patients requiring emergency surgery for perforated peptic ulcer disease. (duke.edu)
- The exact health issue: peptic ulcer disease. (yahoo.com)
- But what exactly is peptic ulcer disease and why would treatment require the Boss to miss his upcoming shows? (yahoo.com)
- Peptic ulcer disease is a break in the lining of the stomach or intestine caused by increased acid," Dr. Judith Kim , a gastroenterologist at NYU Langone Health, told HuffPost via email. (yahoo.com)
- Basically, peptic ulcer disease is a fancy medical way of saying that someone has stomach ulcers or duodenal ulcers, which are defects in the first part of the small intestine (known as the duodenum). (yahoo.com)
- In addition to abdominal pain, common symptoms of peptic ulcer disease include nausea, blood in the stool and poor appetite or feeling full quickly after eating. (yahoo.com)
- The most common cause of peptic ulcer disease worldwide is the bacteria H. pylori," said Dr. Harmony Allison , a gastroenterologist at Tufts Medical Center in Boston. (yahoo.com)
- Another common misconception around the cause of peptic ulcer disease is that it stems from certain foods or stress. (yahoo.com)
- The incidence of peptic ulcer disease increases with age," Kim said. (yahoo.com)
- A breath or stool test can also help identify peptic ulcer disease caused by H. pylori. (yahoo.com)
- In rare cases, peptic ulcer disease might require surgical treatment, but most of the time there are less invasive options. (yahoo.com)
- Of 470 patients treated for peptic ulcer disease, 215 were seen during Ramadan and 255 in the month after Ra- madan. (who.int)
- The frequency of peptic ulcer disease was higher after Ramadan than during Ramadan but this was not statistically significant. (who.int)
- Peptic ulcer disease occurred more frequently in the age group 30-49 years. (who.int)
- Regression analysis identified the following variables as predictors of peptic ulcer disease: anorexia, pain, hypertension, smoking, epigastric pain, diabetes and family history. (who.int)
Duodenum8
- A peptic ulcer is a round or oval sore where the lining of the stomach or duodenum has been eaten away by stomach acid and digestive juices. (merckmanuals.com)
- Ulcers penetrate into the lining of the stomach or duodenum (the first part of the small intestine). (merckmanuals.com)
- Duodenal ulcers, the most common type of peptic ulcer, occur in the first few inches of the duodenum. (merckmanuals.com)
- Stress ulcers occur in the stomach and the duodenum. (merckmanuals.com)
- Ulcers develop when the normal defense and repair mechanisms of the lining of the stomach or duodenum are weakened, making the lining more likely to be damaged by stomach acid. (merckmanuals.com)
- A peptic ulcer is a defect in the lining of your stomach or the first part of your small intestine, the duodenum. (mountsinai.org)
- A defect in your duodenum is called a duodenal ulcer. (mountsinai.org)
- A peptic ulcer is an erosion in a segment of the gastrointestinal mucosa, typically in the stomach (gastric ulcer) or the first few centimeters of the duodenum (duodenal ulcer), that penetrates through the muscularis mucosae. (msdmanuals.com)
Etiology1
- Treatment of peptic ulcers varies depending on the etiology and clinical presentation. (medscape.com)
Common cause of peptic1
- It is a common cause of peptic ulcers, affecting around 30-40% of people in the United States. (medicalnewstoday.com)
Causes of peptic ulcers1
- According to a study from 2012 , H. pylori and NSAIDs are the most prevalent causes of peptic ulcers. (medicalnewstoday.com)
People with peptic ulcers2
- Most people with peptic ulcers have these bacteria living in their digestive tract. (medlineplus.gov)
- This could be one reason for an abnormal secretion of hydrochloric acid in people with peptic ulcers. (rawfoodexplained.com)
Develop peptic ulcers2
- However, most people who take NSAIDs do not develop peptic ulcers. (merckmanuals.com)
- Then why doesn't everyone develop peptic ulcers? (rawfoodexplained.com)
Diagnosis of peptic1
- diagnosis of peptic ulcer. (who.int)
Gastritis1
- Stress ulcers, like those that form in acute stress gastritis, can occur as a result of the stress of severe illness, skin burns, or injury. (merckmanuals.com)
Esophageal and Gas1
- In variceal hemorrhage, the underlying pathophysiology is an elevated portal pressure transmitted to esophageal and gastric varices and resulting in portal gastropathy. (medscape.com)
NSAIDs4
- Your ulcer is caused by taking aspirin or NSAIDs. (medlineplus.gov)
- A major cause of peptic ulcer, although far less common than H.pylori or NSAIDS, is Zollinger-Ellison syndrome. (mountsinai.org)
- NSAIDs can also decrease the blood's clotting ability, which can make ulcers more likely to bleed. (medicalnewstoday.com)
- Many authorities recommend simple oversewing of the ulcer with treatment of the underlying H pylori infection or cessation of NSAIDs for bleeding PUD. (medscape.com)
Duodenal ulcer2
- A family history exists in 50 to 60% of children with duodenal ulcer. (msdmanuals.com)
- [ 26 ] In one study, at least 2 risk factors (previous duodenal ulcer, H pylori infection, use of ASA/NSAID, and smoking) were present in two thirds of persons with acute gastroduodenal bleeding. (medscape.com)
Development of ulcers2
- The time to halt the development of ulcers is at the first sign of enervation. (rawfoodexplained.com)
- Although we do think of stress as contributing to the development of ulcers, that doesn't typically refer to the stress of daily life. (yahoo.com)
Intracranial hemorrhage1
- intracranial hemorrhage and hemophilia. (sandarmyaingmyanmar.com)
Helicobacter1
- The most common cause of ulcers is infection of the stomach by bacteria called Helicobacter pylori ( H pylori ). (medlineplus.gov)
Ulceration1
- Gastric acid hypersecretion and aggressive, refractory peptic ulceration result (Zollinger-Ellison. (msdmanuals.com)
Bleeding31
- Some ulcers can cause serious bleeding. (medlineplus.gov)
- For those children with bleeding, 8 had simple oversew of the bleeding ulcer(s), 2 had oversew with vagotomy and pyloroplasty, and 1 required vagotomy and antrectomy. (nih.gov)
- The image below depicts an ulcer with active bleeding. (medscape.com)
- Ulcer with active bleeding. (medscape.com)
- Variceal hemorrhage is not discussed in this article because the underlying mechanisms of bleeding are different and require different therapies. (medscape.com)
- A bleeding ulcer is seen below. (medscape.com)
- An actively bleeding ulcer may also be cauterized (blood vessels are sealed with a burning tool) during a gastroscopy procedure. (mountsinai.org)
- Endoscopic therapy can be used to stop bleeding from the ulcer. (mountsinai.org)
- Bleeding ulcer: What causes it and is it serious? (medicalnewstoday.com)
- If an ulcer develops at the site of a blood vessel, it can cause bleeding. (medicalnewstoday.com)
- Excessive ulcer bleeding is a medical emergency as it can cause rapid blood loss and death. (medicalnewstoday.com)
- Doctors refer to these as bleeding ulcers. (medicalnewstoday.com)
- Severe bleeding, known as hemorrhaging, can be life threatening. (medicalnewstoday.com)
- Minor bleeding in an ulcer is typically not as serious and may go unnoticed. (medicalnewstoday.com)
- Infections and some medications can cause bleeding ulcers. (medicalnewstoday.com)
- Using the correct treatment, doctors can cure bleeding ulcers. (medicalnewstoday.com)
- Diagnosis and treatment of bleeding ulcers typically involve an endoscopy . (medicalnewstoday.com)
- A severe bleeding ulcer left untreated can cause rapid blood loss and even death. (medicalnewstoday.com)
- A slow-bleeding ulcer may gradually cause anemia . (medicalnewstoday.com)
- Scholars@Duke publication: Vagotomy/drainage is superior to local oversew in patients who require emergency surgery for bleeding peptic ulcers. (duke.edu)
- OBJECTIVE: To compare early postoperative outcomes of patients undergoing different types of emergency procedures for bleeding or perforated gastroduodenal ulcers. (duke.edu)
- Conversely, vagotomy/drainage was associated with a significantly lower postoperative mortality rate than local ulcer oversew when performed for bleeding ulcers. (duke.edu)
- For patients requiring emergency operation for intractable ulcer bleeding, vagotomy/drainage is associated with lower postoperative mortality than with simple ulcer oversew. (duke.edu)
- Age is an independent risk factor for the incidence and mortality from bleeding peptic ulcer, with the risk increasing in persons older than 65 years and increasing further in those older than age 75 years. (medscape.com)
- The principles of management of bleeding peptic ulcers outlined below are equally applicable to both gastric and duodenal ulcers. (medscape.com)
- Upper GI bleeding secondary to a bleeding peptic ulcer is a common medical condition. (medscape.com)
- Endoscopic evaluation of the bleeding ulcer can decrease the duration of the hospital stay by identifying patients at low risk for rebleeding. (medscape.com)
- Patients are at risk of haemorrhage from This was a 28-year-old male, the first son multiple sites (especially the nasal mucosa), of the patient in Case 2, with a similar his- pulmonary haemorrhage, high-output car- tory, faintness, gastrointestinal bleeding and diac failure, ischaemic stroke, migraine and feebleness. (who.int)
- If the ulcer is actively bleeding at the time of endoscopy, there are techniques and tools we can use to stop the bleeding," said Dr. Kevin Cronley , a gastroenterologist with Gastro Health in Cincinnati. (yahoo.com)
- Camus M, Jensen DM, Kovacs TOG, Jensen ME, Markovic D, Gornbein J. Independent Risk Factors of 30 day Outcomes in 1264 patients with Peptic Ulcer Bleeding in the USA - Large Ulcers do worse . (uclahealth.org)
- Jensen DM, Ohning GV, Kovacs TOG, Ghassemi K, Jutabha R, Dulai GS, Machicado GA. Doppler Endoscopic probe as a guide to risk stratification and definitive hemostasis of peptic ulcer bleeding . (uclahealth.org)
Hemorrhoids1
- Treatment of varicose veins, hemorrhoids, gastric and esophageal varices, and peptic ulcer hemorrhage by injection or infusion of chemical agents which cause localized thrombosis and eventual fibrosis and obliteration of the vessels. (bvsalud.org)
Cause ulcers3
- Although alcohol increases stomach acid production, drinking moderate amounts of alcohol does not seem to cause ulcers or delay their healing. (merckmanuals.com)
- Stress may cause ulcers. (merckmanuals.com)
- As a result, your stomach acid can cause ulcers in the lining. (yahoo.com)
Small intestine1
- Peptic ulcers may occur in the stomach , the small intestine just below the stomach, or the esophagus (food pipe) above the stomach. (medicalnewstoday.com)
UPPER GI HEMORRH1
- The initial management of a stable patient with dyspepsia differs from the management of an unstable patient with upper GI hemorrhage. (medscape.com)
Recurrent1
- End points - Frequency of recurrent haemorrhage, need for surgery, and death. (edu.au)
Incidence1
- Also, smoking impairs ulcer healing and increases the incidence of recurrence. (msdmanuals.com)
Obstruction2
- others notice them when some severe symptom such as hemorrhage or obstruction develops. (rawfoodexplained.com)
- This is especially true for pyloric channel ulcers, which are often associated with symptoms of obstruction (eg, bloating, nausea, vomiting) caused by edema and scarring. (msdmanuals.com)
Recurrence1
- These tumors are usually malignant, must be removed and acid production suppressed to relieve the recurrence of the ulcers. (mountsinai.org)
Pylori infection3
- You have an ulcer without an H pylori infection. (medlineplus.gov)
- H. pylori infection is present in 50 to 70% of people with duodenal ulcers and in 30 to 50% of people with stomach ulcers. (merckmanuals.com)
- However, a newer review in the Asian Pacific Journal of Cancer Prevention states that ulcers without H. pylori infection or NSAID involvement are increasing. (medicalnewstoday.com)
Abdominal1
- Larger ulcers can cause abdominal pain, a feeling of fullness in the stomach, and nausea. (mountsinai.org)
Merck Manual1
- According to the Merck Manual , "Peptic ulcer occurs only if the stomach secretes acid. (rawfoodexplained.com)
Occur4
- Most ulcers occur in the first, inner surface, layer of the inner lining. (medlineplus.gov)
- Ulcers can occur at any age, including infancy and childhood, but are most common among middle-aged adults. (merckmanuals.com)
- Gastric ulcers (stomach ulcers) are less common and usually occur in the lower part of the stomach. (merckmanuals.com)
- A single ulcer is most common, but two and occasionally more (duodenal, gastric, or both) do occur. (rawfoodexplained.com)
Mortality rate1
- Our patients were transfused less, and operated upon less often with a lower mortality rate in those with chronic peptic ulcers. (bmj.com)
NSAID2
- NSAID use causes more than 50% of peptic ulcers. (merckmanuals.com)
- Other common ulcer risks include smoking cigarettes, drinking a lot of alcohol, or regularly using NSAID pain relievers like aspirin and ibuprofen. (mountsinai.org)
Infection2
- More likely, your ulcer is caused by a stomach infection with a type of bacteria called H. pylori. (mountsinai.org)
- Racial and ethnic eradicate the infection and cure ulcers have been available differences have been noted, with blacks more affected since Marshall and Warren discovered H. pylori as an eti- than whites and Mexican-Americans more affected than ologic agent of ulcers in the early 1980s ( 3 ). (cdc.gov)
Patients9
- Race/ethnicity more often for duodenal ulcers than were female patients was missing in the record for 26.0% of hospitalizations. (cdc.gov)
- is present in 50 to 70% of patients with duodenal ulcers and in 30 to 50% of patients with gastric ulcers. (msdmanuals.com)
- For patients with perforated ulcers, vagotomy/drainage produced similar outcomes as local procedures but required a significantly greater length of postoperative hospitalization. (duke.edu)
- Documentation of H pylori cure with a noninvasive test, such as the urea breath test or fecal antigen test, is appropriate in patients with complicated ulcers. (medscape.com)
- Objective - To see whether fibrinolytic inhibitors are of value when given to patients with upper gastrointestinal haemorrhage. (edu.au)
- Patients - 1267 Patients admitted to hospital with primary diagnosis of acute upper gastrointestinal haemorrhage. (edu.au)
- Conclusions - Treatment with tranexamic acid may be of value to patients considered to be at risk of dying after an upper gastrointestinal haemorrhage. (edu.au)
- So, it should be used with caution in patients who have lesions with a propensity to bleed (such as ulcer). (sandarmyaingmyanmar.com)
- Jensen DM, Kovacs TOG, Ohning GV, Ghassemi K, Machicado GA, Dulai GS, Sedarat A, Jutabha R, Gornbein J. Doppler Endoscopic Probe Monitoring for Blood Flow Improves Risk Stratification and Outcomes of Patients with Severe Non-Variceal UGI Hemorrhage . (uclahealth.org)
Stomach ulcers1
- There is similar prevalence in men and women, though stomach ulcers tend to be more common in women and ulcers in the intestine more common in men. (yahoo.com)
Endoscopy3
- To detect an ulcer, you may need a test called an upper endoscopy (esophagogastroduodenoscopy or EGD). (medlineplus.gov)
- Endoscopy is required to document healing of gastric ulcers and to rule out gastric cancer. (medscape.com)
- But to make an official ulcer diagnosis, we perform an endoscopy ― look in their stomach with a camera while someone is asleep," Martin said. (yahoo.com)
Complica1
- Only cases of peptic ulcer with pathologic ting is different from other types of fasting conditions leading to peptic ulcer complica- or ongoing food deprivation [ 5 ]. (who.int)
Heal5
- Small ulcers may not cause any symptoms and may heal without treatment. (medlineplus.gov)
- Your health care provider will recommend medicines to heal your ulcer and prevent a relapse. (medlineplus.gov)
- People who smoke are more likely to develop a peptic ulcer than people who do not smoke, and their ulcers heal more slowly and are likely to return. (merckmanuals.com)
- The term "ulcer" means a sore that does not heal quickly. (medicalnewstoday.com)
- These ulcers tend to heal when the drug is discontinued and are unlikely to recur unless the drug is taken again. (rawfoodexplained.com)
Acute2
- K27.0 is a billable diagnosis code used to specify a medical diagnosis of acute peptic ulcer, site unspecified, with hemorrhage. (icdlist.com)
- The Gastroenterology Unit of the Royal Newcastle Hospital treats all acute bleeders in the hospital and has followed a policy of conservative blood transfusion and early surgery directed to gastric ulcer upon rebleeding. (bmj.com)
Proton pump inhib1
- Ulcers are typically treated with proton pump inhibitors which decrease the acid produced by the stomach," Kim said. (yahoo.com)
Intestine2
- A peptic ulcer is an open sore or raw area in the lining of the stomach or intestine. (medlineplus.gov)
- Marginal ulcers can develop when part of the stomach has been removed surgically, at the point where the remaining stomach has been reconnected to the intestine. (merckmanuals.com)
Alcohol3
- To avoid irritating an ulcer a person can try eliminating certain substances from their diet such as caffeine, alcohol, aspirin, and avoid smoking. (mountsinai.org)
- Although alcohol is a strong promoter of acid secretion, no definitive data link moderate amounts of alcohol to the development or delayed healing of ulcers. (msdmanuals.com)
- Smoking and alcohol use are risk factors for ulcers. (yahoo.com)
Nausea1
- Symptoms of ZES may be similar to those of peptic ulcers, such as dull or burning pain in the belly, and digestive problems such as diarrhea , nausea, decreased appetite, bloating, and burping. (medicalnewstoday.com)
Venous2
- When severe leg swelling leads to skin breakdown, it is called venous STASIS ULCER. (lookformedical.com)
- Venous insufficiency often occurs in the legs, and is associated with EDEMA and sometimes with VENOUS STASIS ULCERS at the ankle. (lookformedical.com)
Ischemic1
- The primary goal of the trial is to determine if the experimental arms (rivaroxaban or ticagrelor or both) are superior to the clopidogrel arm for lowering the 1-year rate of ischemic stroke, intracerebral hemorrhage, or vascular death. (clinicaltrials.gov)
Malignant2
- An ulcer is a crater-like lesion on the skin or mucous membrane caused by an inflammatory, infectious, or malignant condition. (mountsinai.org)
- Duodenal ulcers are almost always benign, but a gastric ulcer may be malignant. (rawfoodexplained.com)
Stigmata1
- Ulcers with such stigmata require endotherapy, while ulcers with a clean base need not be treated endoscopically. (medscape.com)
Vascular1
- Thrombosis is an important part of the normal hemostatic response that limits hemorrhage caused by microscopic or macroscopic vascular injury. (medscape.com)
Acid5
- A rare condition, called Zollinger-Ellison syndrome , causes the stomach to produce too much acid, leading to stomach and duodenal ulcers. (medlineplus.gov)
- The term "peptic" means it is related to acid. (medicalnewstoday.com)
- When this happens, the acid may damage the lining of the digestive tract and cause an ulcer. (medicalnewstoday.com)
- These tumors cause the stomach to produce more acid than it needs, leading to peptic ulcers. (medicalnewstoday.com)
- BACKGROUND: Although definitive acid-reducing procedures are being used less frequently during emergency ulcer surgery, there is little published data to support this change in practice. (duke.edu)
Bacteria2
- Yet, many people who have these bacteria in their stomach do not develop an ulcer. (medlineplus.gov)
- Tissue samples may be obtained to check for H pylori bacteria, a cause of many peptic ulcers. (mountsinai.org)
Penetrate1
- Ulcers penetrate into the submucosa or muscular layer. (rawfoodexplained.com)
Tend1
- Duodenal ulcers tend to cause more consistent pain. (msdmanuals.com)
Treatment2
Digestive1
- Often, when people refer to an ulcer, they mean peptic ulcers , which develop in the digestive tract. (medicalnewstoday.com)
Varices1
- Tratamiento de venas varicosas, hemorroides, varices esofágicas y gástricas, y hemorragias producidas por úlceras pépticas por la inyección o infusión de agentes quÃmicos que producen trombosis localizada y en último término fibrosis y obliteración de los vasos. (bvsalud.org)