Perilla frutescens
Perilla
Lamiaceae
Cinnamates
Antimicrobial activity of perilla seed polyphenols against oral pathogenic bacteria. (1/27)
A perilla seed (Perilla frutescens Britton var. japonica Hara) extract was examined for its antimicrobial activity against oral cariogenic streptococci and periodontopathic Porphyromonas gingivalis. Luteolin, one of the components of perilla seed, showed the strongest antimicrobial effect among the phenolic compounds. According to our results, perilla seed may be the source of an antimicrobial agent that could prevent dental caries and periodontal diseases. (+info)Luteolin as an anti-inflammatory and anti-allergic constituent of Perilla frutescens. (2/27)
Oral administration of the perilla leaf extract (PLE) to mice inhibits inflammation, allergic response, and tumor necrosis factor-alpha production. We also found that PLE suppressed the tumor necrosis factor-alpha (TNF-alpha) production in vitro. Using the inhibitory activity of TNF-alpha production in vitro as the index for isolation, we searched the active constituents from PLE and isolated luteolin, rosmarinic acid and caffeic acid as active components. Among the isolated compounds, only luteolin showed in vivo activity: inhibition of serum tumor necrosis factor-alpha production, inhibition of arachidonic acid-induced ear edema, inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ear edema and inhibition of oxazolone-induced allergic edema. These results suggest that luteolin is a genuinely active constituent which is accountable for the oral effects of perilla. (+info)Suppressive effects of Perilla frutescens on IgA nephropathy in HIGA mice. (3/27)
BACKGROUND: Perilla frutescens (perilla) is a herbal medicine used in Japanese traditional Kampo medicine. The present study was conducted to evaluate the anti-nephritic effects of perilla in HIGA mice that spontaneously develop high levels of serum immunoglobulin A (IgA) along with mesangial IgA deposition. METHODS: A perilla decoction and its major active constituent, rosmarinic acid (RsA), were orally administrated to 10-week-old HIGA mice for 16 weeks. At study completion, we measured proteinuria and serum IgA levels and generated histological scores from kidney specimens. In addition, we measured concentrations of IgA in culture media of intestinal Peyer's patch cells and spleen cells obtained from the HIGA mice. RESULTS: Perilla suppressed proteinuria, proliferation of glomerular cells, serum levels of IgA, glomerular IgA and IgG depositions in HIGA mice. Cultured Peyer's patch cells and spleen cells from perilla-treated mice produced significantly less IgA than controls. Rosmarinic acid, by itself, suppressed serum IgA levels and glomerular IgA deposition in HIGA mice. Cultured spleen cells from RsA-treated mice produced less IgA than controls. CONCLUSIONS: The perilla decoction may suppress IgA nephropathy, in part, through modulation of the intestinal mucosal immune system. These effects were caused by RsA acting synergistically with other constituents. (+info)Antidepressant-like effects of apigenin and 2,4,5-trimethoxycinnamic acid from Perilla frutescens in the forced swimming test. (4/27)
We studied the effects of apigenin and 2,4,5-trimethoxycinnamic acid (TMCA) on the behavioral despair test (forced swimming test), and the central noradrenergic, dopaminergic and serotonergic activities in mice. Apigenin at intraperitoneal doses of 12.5 and 25 mg/kg significantly decreased the duration of immobility in the forced swimming test in mice. At 100 mg/kg, the duration of immobility was returned to the control level in the test. On the other hand, TMCA treatment (25-200 mg/kg, i.p.) failed to significantly alter the duration of immobility. Based on the behavioral data, we examined changes in the monoamine turnover in mice having been subjected to forced swimming for 40 min. The monoamine turnover was measured in seven brain regions. Forced swimming exposure induced a significant decrease in dihydroxyphenylacetic acid (DOPAC)/dopamine (DA) in the striatum and amygdala and in 5-hydroxyindoleacetic acid (5-HIAA)/5-hydroxytriptamine (5-HT) in the hypothalamus, and a significant increase in DOPAC/DA in the thalamus and hypothalamus and in 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG)/norepinephrine (NE) in the amygdala, frontal cortex, hypothalamus, and midbrain. Apigenin (25 mg/kg) treatment produced attenuation of forced swim test-induced decrease of DA turnover in the amygdala and increase of DA turnover in the hypothalamus. Furthermore, intraperitoneal administration of haloperidol (0.2 mg/kg), a dopamine D(2) antagonist, blocked the apigenin (25 mg/kg)-induced decrease in immobility in the forced swimming test. These behavioral and biochemical results indicate the antidepressant properties of apigenin, which may be mediated by the dopaminergic mechanisms in the mouse brain. (+info)Inhibitory effect of Perilla leaf extract and luteolin on mouse skin tumor promotion. (5/27)
In the present study, the effects of perilla leaf extract (PLE) and luteolin on 7,12-dimethylbenz[a]anthracene (DMBA)- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin papillomas in mice were investigated. Topical application of PLE prior to TPA treatment in DMBA-initiated mouse skin resulted in a significant reduction in tumor incidence and multiplicity. An even more potent preventive effect was observed with topical application of luteolin, which we previously identified as an antiinflammatory constituent. PLE was dissolved in drinking water at a 0.05% dose and mice ingested it ad libitum; no significant difference was observed in tumor incidence or multiplicity but there was a significant reduction in tumor volume between the PLE-treated and untreated groups. These results suggest that PLE has potent antipromotion activity and ingesting it as a daily food may provide a beneficial chemopreventive effect. (+info)Rosmarinic acid inhibits epidermal inflammatory responses: anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model. (6/27)
Perilla frutescens extract showed marked reduction on tumorigenesis in a murine, two-stage skin carcinogenesis model. In this model, cancer is initiated by application of 7,12-dimethylbenz[a]anthracene (DMBA) and promoted by application of 12-tetradecanoylphorbol 13-acetate (TPA). Following tumor initiation with DMBA, topical application of a perilla-derived fraction (PF) at doses of 2 mg/mouse/application resulted in significant inhibition of tumorigenesis. The efficacy of each fraction was correlated with rosmarinic acid (RA) and luteolin concentration. Topical application of perilla extract (PE) that contained 68% RA or an equivalent amount of commercially available RA showed nearly identical antiinflammatory activity 5 h after TPA treatment. Application of luteolin had less anti-inflammatory activity. Marked neutrophil infiltration was observed in TPA-challenged skin by histological examination using hematoxylin-eosin. This change was greatly reduced by pre-treatment with PE or RA. Myeloperoxidase activity, a marker of neutrophil recruitment, was also increased in TPA-challenged skin and was significantly decreased in the PE and RA treated groups. Intercellular adhesion molecule 1 and vascular cell adhesion molecule-1 mRNA expression levels were reduced by pre-treatment with PE or RA. TPA-induced increases in synthesis of the chemokines KC and macrophage inflammatory protein-2 were significantly decreased by pre-treatment with PE or RA. Prostaglandin E2 and leukotriene B4 levels were slightly increased 5 h after TPA treatment. These levels were only numerically decreased in the PE and RA treated groups. However, induction of cyclooxygenase-2 mRNA expression was obviously reduced by pre-treatment with PE or RA. Reactive oxygen radical production, detected as thiobarbituric acid reactive substance and lipid peroxide, by double treatment of TPA was reduced by pre-treatment with PE or RA. Production of 8-hydroxy-2'deoxyguanosine, which was detected immunohistochemically, was also induced by double treatment with TPA. This adduct was barely visible in PE or RA treated mice. Thus, we conclude that part of the anticarcinogenic effects of P.frutescens extract is due to RA via two independent mechanisms: inhibition of the inflammatory response and scavenging of reactive oxygen radicals. (+info)Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects. (7/27)
Nine triterpene acids, viz., six of the ursane type, ursolic acid (1), corosolic acid (2), 3-epicorosolic acid (3), pomolic acid (4), tormentic acid (5) and hyptadienic acid (6), and three of the oleanane type, oleanolic acid (7), augustic acid (8) and 3-epimaslinic acid (9), among which 1 constituted the most predominant triterpene acid, were isolated and identified from ethanol extracts of the leaves of red perilla [Perilla frutescens (L.) Britton var. acuta Kudo] and green perilla [P. frutescens (L.) Britton var. acuta Kudo forma viridis Makino]. These eight compounds, 1, 2, 4-9, were evaluated for their inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation (1 microg/ear) in mice. All the compounds tested showed a marked anti-inflammatory effect, with a 50% inhibitory dose (ID50) of 0.09-0.3 mg per ear. In addition, an evaluation against the Epstein-Barr virus early antigen (EBV-EA) activation induced by TPA showed five compounds, 1-3, 5 and 9, with a potent inhibitory effect on EBV-EA induction (91-93% inhibition at 1x10(3) mol ratio/TPA). Furthermore, compound 5 exhibited strong antitumor-promoting activity in an in vivo two-stage carcinogenesis test of mouse tumor by using 7,12-dimethylbenz(a)anthracene (DMBA) as an initiator and TPA as a promoter. (+info)Paenibacillus elgii sp. nov., with broad antimicrobial activity. (8/27)
Two novel spore-forming bacteria with broad antimicrobial activity were isolated from roots of Perilla frutescens. The isolates, SD17(T) and SD18, were facultatively anaerobic and showed variable Gram reaction. Growth was observed between 20 and 45 degrees C. DNA G+C content of SD17(T) was 51.7 mol%, and the major fatty acid was anteiso-C(15 : 0) (54.1 %). 16S rRNA gene sequence similarity of SD17(T) ranged from 98.6 to 91.3 % with other Paenibacillus species. The phylogenetic tree showed that isolate SD17(T) formed a significant monophyletic clade with Paenibacillus koreensis KCTC 2393(T) and Paenibacillus ehimensis IFO 15659(T). DNA-DNA relatedness values for strain SD17(T) with Paenibacillus koreensis KCTC 2393(T) and Paenibacillus ehimensis IFO 15659(T) were 17.4 and 19.8 %, respectively. These isolates thus merit species status within Paenibacillus, for which the name Paenibacillus elgii sp. nov. is proposed. The type strain is SD17(T) (=KCTC 10016BP(T)=NBRC 100335(T)). (+info)'Perilla frutescens' is not a medical term itself, but it refers to a plant species also known as the beefsteak plant or Chinese basil. While it doesn't have a specific medical definition, some components of this plant have been studied for their potential medicinal properties. For instance, Perilla frutescens contains rosmarinic acid and luteolin, which have been researched for their anti-inflammatory, antioxidant, and neuroprotective effects. However, it is essential to note that further research is required before any definitive medical claims can be made about the plant or its components.
Perilla, also known as Perilla frutescens, is an herb from the mint family (Lamiaceae) that is native to Asia. It has been used in traditional medicine and cooking for centuries. In a medical context, perilla refers to the plant itself or its components, such as its leaves, seeds, and oils.
Perilla contains various bioactive compounds, including rosmarinic acid, luteolin, and α-linolenic acid (ALA), which contribute to its potential health benefits. Some studies suggest that perilla may have anti-inflammatory, antioxidant, neuroprotective, and antiasthmatic properties. However, more research is needed to fully understand its effects and establish recommended dosages for medical use.
It's important to note that perilla supplements or extracts can interact with certain medications and may have side effects. Therefore, it's crucial to consult a healthcare professional before using perilla products for medicinal purposes.
Depsides are a type of chemical compound that are formed by the condensation of two molecules of phenolic acids. They are a subclass of polyphenols, which are compounds found in plants that have various biological activities. Depsides are characterized by the presence of a central core structure consisting of a benzene ring linked to a carboxylic acid group through a carbon-carbon bond.
Depsides can be further classified into different subgroups based on the specific phenolic acids that make up their structure. Some common examples of depsides include chlorogenic acid, which is formed from caffeic acid and quinic acid, and rosmarinic acid, which is formed from caffeic acid and 3,4-dihydroxyphenyllactic acid.
Depsides have been studied for their potential health benefits, including antioxidant, anti-inflammatory, and antimicrobial activities. They are found in a variety of plant foods, such as fruits, vegetables, herbs, and spices, and may contribute to the overall health-promoting properties of these foods.
I apologize for the confusion, but "Lamiaceae" is not a medical term. It is a taxonomic category in biology, specifically it is a family of flowering plants that includes many familiar herbs such as mint, rosemary, sage, basil, and lavender. These plants are often used in medicine, cooking, and for ornamental purposes. The Lamiaceae family is characterized by their square stems, opposite leaves, and two-lipped flowers.
Cinnamates are organic compounds that are derived from cinnamic acid. They contain a carbon ring with a double bond and a carboxylic acid group, making them aromatic acids. Cinnamates are widely used in the perfume industry due to their pleasant odor, and they also have various applications in the pharmaceutical and chemical industries.
In a medical context, cinnamates may be used as topical medications for the treatment of skin conditions such as fungal infections or inflammation. For example, cinnamate esters such as cinoxacin and ciclopirox are commonly used as antifungal agents in creams, lotions, and shampoos. These compounds work by disrupting the cell membranes of fungi, leading to their death.
Cinnamates may also have potential therapeutic benefits for other medical conditions. For instance, some studies suggest that cinnamate derivatives may have anti-inflammatory, antioxidant, and neuroprotective properties, making them promising candidates for the development of new drugs to treat diseases such as Alzheimer's and Parkinson's. However, more research is needed to confirm these effects and determine their safety and efficacy in humans.
A plant extract is a preparation containing chemical constituents that have been extracted from a plant using a solvent. The resulting extract may contain a single compound or a mixture of several compounds, depending on the extraction process and the specific plant material used. These extracts are often used in various industries including pharmaceuticals, nutraceuticals, cosmetics, and food and beverage, due to their potential therapeutic or beneficial properties. The composition of plant extracts can vary widely, and it is important to ensure their quality, safety, and efficacy before use in any application.
Perilla frutescens
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Perilla frutescens - Wikipedia
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Crispa2
- Perilla crispa (Thunb. (theferns.info)
- Perilla frutescens crispa is an erect, often profusely branched, annual to perennial plant growing 30 - 200cm tall. (theferns.info)
Called Korean perilla1
- frutescens) - called Korean perilla or deulkkae. (wikipedia.org)
Lamiaceae2
- Perilla frutescens, also called deulkkae or Korean perilla, is a species of Perilla in the mint family Lamiaceae. (wikipedia.org)
- A member of the Lamiaceae, or mint, family, perilla mint usually reaches an average height of 2 feet at maturity. (msstate.edu)
Britt2
- Perilla frutescens (L.) Britt is widely used as an edible and medicinal plant in Asian countries, and its fruits have been adopted in Chinese pharmacopoeia as a traditional Chinese medicine (TCM). (rsc.org)
- Integration of transcriptomics and proteomics to elucidate inhibitory effect and mechanism of rosmarinic acid from Perilla frutescens (L.) Britt. (biomedcentral.com)
Seeds14
- Perilla seeds can be soft or hard, being white, grey, brown, and dark brown in colour and globular in shape. (wikipedia.org)
- Perilla seeds contain about 38-45% lipid. (wikipedia.org)
- In its natural state, the yield of perilla leaves and seeds is not high. (wikipedia.org)
- To collect perilla seeds, the whole plant is harvested, and the seeds are beat out of the plant, before being spread for sun drying. (wikipedia.org)
- Perilla seeds are rich in dietary fiber and dietary minerals such as calcium, iron, niacin, protein, and thiamine. (wikipedia.org)
- In India, perilla seeds are roasted and ground with salt, chilis, and tomatoes to make a savoury side dish or chutney. (wikipedia.org)
- In Kumaon, the seeds of cultivated perilla are eaten raw, the seed oil is used for cooking purposes, and the oil cake is consumed raw or fed to cattle. (wikipedia.org)
- The seeds and leaves of perilla are also used for flavoring curries in north east India. (wikipedia.org)
- Beefsteak Plant (Perilla Frutescens) - Start Perilla frutescens seeds for a beautiful foliage plant that is also a great culinary herb. (outsidepride.com)
- The Perilla seeds are used to make nutritious cooking oil as well. (outsidepride.com)
- How To Grow Perilla From Herb Seeds: Start the herb seeds indoors 4 - 6 weeks before the end of frost season is expected. (outsidepride.com)
- Our open-pollinated Korean Perilla seeds are guaranteed to be free from any GMO contamination and of the highest quality available. (amkhaseed.com)
- frutescens is also used as a vegetable only in Korea, and its seeds are traditionally used in the same way that sesame seeds are used as a seasoning in China, Korea, and Japan from old times. (geneticsmr.org)
- For best results, Perilla seeds should be cold stratified prior to sowing. (edenseeds.com.au)
Extract3
- In a 4-week study, 80 percent of subjects who took Benegut® Perilla extract reported substantial improvement of gastrointestinal discomfort. (fullscript.com)
- One such ingredient that has been gaining popularity in recent years is Korean perilla, a powerful plant extract that is known for its soothing, moisturizing, and restorative properties. (ushops.com)
- Perilla leaf extract is known for its anti-inflammatory properties, which can help to calm the skin and reduce the appearance of acne, rosacea, and other skin conditions. (ushops.com)
Coleus1
- Red perilla is an ornamental edible which resembles coleus. (summerhillseeds.com)
Plants1
- Transplant the Perilla plants outside once temperatures are consistently warm. (outsidepride.com)
Leaf1
- The Perilla Hydro Jelly Modeling Mask is a skincare product that is formulated with a variety of botanical extracts, including perilla leaf, basil leaf, tea tree leaf, and Centella Asiatica. (ushops.com)
Acuta1
- Perilla acuta (Thunb. (theferns.info)
Korean3
- It is also referred to as Korean perilla, due to its extensive cultivation in Korea and use in Korean cuisine. (wikipedia.org)
- What is Korean Perilla? (ushops.com)
- Korean perilla, also known as perilla frutescens var. (ushops.com)
Edible2
- An edible plant, perilla is grown in gardens and attracts butterflies. (wikipedia.org)
- Although perilla is widely cultivated as an edible plant for humans, it is toxic to cattle and other ruminants, as well as horses. (wikipedia.org)
Genus1
- The genus name Perilla comes from the Latin word pera meaning bag in reference to the shape of the fruiting calyx. (ncsu.edu)
Widely2
- As a culinary herb, Perilla is a sweet-spicy flavoring that is widely used in oriental cuisine such as stir fries, raw fish, vegetable dishes, rice and soups. (outsidepride.com)
- Perilla leaves, also known as Perilla frutescens, are widely used in Chinese medicine to cure a variety of ailments. (signalscv.com)
Ketones1
- Several volatile compounds, like perilla ketones, exist in perilla mint and cause atypical interstitial pneumonia (AIP) in cattle and other domestic animals. (msstate.edu)
Problematic2
- In this blog post, we will explore the features and benefits of the Perilla Hydro Jelly Modeling Mask and how it can help those with problematic skin. (ushops.com)
- Whether you have sensitive, dry, or problematic skin, the Perilla Hydro Jelly Modeling Mask may be just what you need to achieve a healthy, glowing complexion. (ushops.com)
Species2
- A self-pollinating species, perilla mint typically begins flowering in late July to August, producing flower spikes up to 6 inches long ( Figure 3 ). (msstate.edu)
- In pastures, the invasive perilla competes with beneficial forage species, especially during intervals of limited rainfall. (msstate.edu)
Luteolin1
- The top five potential antifungal compounds in P. frutescens screened by network pharmacology are: progesterone, luteolin, apigenin, ursolic acid and rosmarinic acid. (biomedcentral.com)
Leaves3
- Perilla leaves are also rich in vitamins A, C and riboflavin. (wikipedia.org)
- The perilla buns are made with glutinous sorghum or glutinous rice flour dough filled with red bean paste and wrapped with perilla leaves. (wikipedia.org)
- The red color of the Perilla leaves is used to color and pickle fruits and vegetables. (outsidepride.com)
Compounds2
- This is the first study to explore the inhibitory effects of compounds from P. frutescens on Trichophyton mentagrophytes and its mechanism of action coupled with the antifungal activity in vitro from network pharmacology, transcriptomics and proteomics. (biomedcentral.com)
- Five most potential inhibitory compounds against fungi in P. frutescens was screened with network pharmacology. (biomedcentral.com)
Blend1
- Powered by our signature vc10 concentration of 10% stabilized vitamin C triple-sourced from C derivatives + natural acerola cherries, plus a blend of perilla frutescens, alpha arbutin, licorice root and niacinamide - it increases luminosity, evens tone + discoloration, targets pores, and helps support collagen. (bioelements.com)
Erect1
- Perilla mint is an erect, herbaceous annual weed originally from eastern Asia. (msstate.edu)
Cultivation1
- In Mississippi, perilla mint has escaped cultivation and frequently occurs in natural areas, including pastures. (msstate.edu)
Fruits2
Cholesterol1
- Perilla - Perilla Frutescens supports HDL cholesterol because it lowers LDL cholesterol. (ipsnews.net)
Herb1
- Grow Perilla herb in full sun and in rich, moist, and well-drained soil. (outsidepride.com)
Genetic3
- In this study, 21 simple sequence repeat (SSR) markers were used to evaluate the genetic diversity and population structure among 77 Perilla accessions from high-latitude and middle-latitude areas of China. (geneticsmr.org)
- The level of genetic diversity and PIC value for cultivated accessions of Perilla frutescens var. (geneticsmr.org)
- Koezuka Y, Honda G and Tabata M (1986) Genetic control of phenylpropanoids in Perilla frutescens. (scielo.br)
Skincare2
- Experience a holistic approach to skincare with our Cnoidal Wave Perilla Oil & Oatmeal Facial. (coastalclassiccreations.com)
- If you are looking for a new skincare product to add to your routine, consider giving the Perilla Hydro Jelly Modeling Mask a try. (ushops.com)
Grown2
- frutescens is currently the most grown and is used as both an oil crop and a leafy vegetable in Korea. (geneticsmr.org)
- frutescens is grown in the northern area of China. (geneticsmr.org)
Occur1
- When populations occur on grazing lands or fields harvested for hay, perilla mint poses serious health risks to livestock. (msstate.edu)
Cattle1
- In the United States, perilla is a weed pest, toxic to cattle after ingestion. (wikipedia.org)
Annual1
- Perilla is an annual plant growing 60-90 cm (24-35 in) tall, with stalks which are hairy and square. (wikipedia.org)
Wild2
- Nitta, 2001 ) although the wild ancestor of cultivated types of Perilla crop has not yet been identified in East Asia. (geneticsmr.org)
- The data obtained on the tocopherol content demonstrate that the seed specific expression of P. frutescens (gamma)-TMT gene resulted in a dramatic change in the tocopherol composition of the transgenic soybean seed compared to wild-type seed. (usda.gov)
Variety1
- A variety of this plant, P. frutescens var. (wikipedia.org)
Skin4
- Discover the incredible power of our Cnoidal Wave Perilla Seed Facial Oil, a perfect solution carefully made for all skin types. (coastalclassiccreations.com)
- Experience the excellent benefits of our Cnoidal Wave Perilla Seed Facial Oil and unlock the secret to healthy, glowing skin. (coastalclassiccreations.com)
- One of the primary benefits of the Perilla Hydro Jelly Modeling Mask is its ability to soothe the skin. (ushops.com)
- Another key benefit of the Perilla Modeling Mask is its ability to moisturize the skin. (ushops.com)
Alpha1
- In order to increase the soybean seed (alpha)-tocopherol content, the (gamma)-tocopherol methyltransferase [(gamma)-TMT] gene isolated from the Perilla frutescens was overexpressed specifically in the seed. (usda.gov)
Growth1
- The key findings of the present study manifested that rosmarinic acid, a medicinal compound extracted from P. frutescens , had pharmacological activity in inhibiting the growth of Trichophyton mentagrophytes by affecting its enolase expression to reduce metabolism. (biomedcentral.com)
Activities1
- Two Pairs of 7,7'-Cyclolignan Enantiomers with Anti-Inflammatory Activities from Perilla frutescens . (bvsalud.org)
Effective2
- Several herbicides are highly effective for controlling perilla mint. (msstate.edu)
- Perilla was most effective in reducing bloating and abdominal discomfort in women. (fullscript.com)
Specific1
- While the specific epithet frutescens means shrubby or bushy. (ncsu.edu)