Phyllodes Tumor
Fibroadenoma
Neoplasms, Fibroepithelial
Adenofibroma
Mastectomy, Simple
Stromal Cells
Biopsy, Large-Core Needle
Tumor Markers, Biological
Molecular analysis of phyllodes tumors reveals distinct changes in the epithelial and stromal components. (1/101)
Phyllodes tumors are fibroepithelial mammary lesions that tend to behave in a benign fashion but may undergo sarcomatous transformation. A study of clonality in these tumors has suggested that the epithelial component is polyclonal, but the stroma is monoclonal, and thus forms the neoplastic component of the lesion. In this study microsatellites on chromosome 1q and chromosome 3p were assessed for allelic imbalance (AI) in 47 phyllodes tumors; in all cases stroma and epithelium were analyzed separately. Ten of 42 (24%) phyllodes tumors showed AI at one or more markers on 3p, and 14 of 46 (30%) showed AI on chromosome 1. Five tumors had changes in both the epithelium and stroma. Eight tumors had changes only detectable in the stroma and eight, changes in the epithelium only. Three tumors exhibited low-level microsatellite instability in the epithelium but not in the stroma. The results show that AI on 3p and 1q does occur in phyllodes tumors and that it can occur in both the stroma and epithelium, sometimes as independent genetic events. These unexpected findings throw into doubt the classical view that phyllodes tumors are simply stromal neoplasms and raise questions about the nature of stromal and epithelial interactions in these tumors. (+info)Malignant phyllodes tumor in the right breast and invasive lobular carcinoma within fibroadenoma in the other: case report. (2/101)
CONTEXT: The malignant variety of the phyllodes tumor is rare. The occurrence of invasive lobular carcinoma within fibroadenoma is rare as well. DESIGN: Case report. CASE REPORT: A 58-year-old black female patient was referred to the Mastology unit of the Department of Gynecology, Federal University of Sao Paulo / Escola Paulista de Medicina, in February 1990, presenting an ulcerated tumor in the right breast with fast growth over the preceding six months. She was a virgin, with meno-pause at the age of 45 years and had not undergone hormone replacement treatment. The physical examination showed, in her right breast, an ulcerated tumor of 20 x 30 cm which was not adher-ent to the muscle level, multilobular and with fibroelastic consistency. The axillary lymph nodes were not palpable. The left breast showed a 2 x 3 cm painless, movable nodule, with well-defined edges, and fibroelastic consistency. We performed left-breast mammography, which showed several nodules with well-defined edges, the largest being 2 x 3 cm and exhibiting rough calcification and grouped microcalcifications within it. The patient underwent a frozen biopsy that showed a malignant variant of the phyllodes tumor in the right breast and fibroadenoma in the left one. After that, we performed a total mastectomy in the right breast and an excision biopsy in the left one. Paraffin study confirmed the frozen biopsy result from the right breast, yet we observed that in the interior of the fibroadenoma that was removed on the left, there was a focal area of invasive lobular carcinoma measuring 0.4 cm. The patient then underwent a modi-fied radical mastectomy with total axillary lymphadenectomy. None of the 21 dissected lymph nodes showed evidence of metastasis. In the follow-up, the patient evolved asymptomatically and with normal physical and laboratory examination results up to July 1997. (+info)Connective tissue stromal changes in tumours and tumour-like lesions of the breast. (3/101)
Between June 1994 and December 1995, one hundred and fifteen tumours and tumour-like lesions of the breast were studied in the Department of Pathology, Kasturba Medical College, Mangalore. Neoplasms constituted 80.9% and tumour like lesions accounted for 19.13%. Among the tumours, 51.6% were benign and 48.4% were malignant. Tumour-like lesions included the entire spectrum of fibrocystic disease. Tumours were common between 2nd and 8th decades while tumour-like lesions were uncommon above 6th decade. Whereas benign tumours exhibited ground substance, collagen and reticulin fibres in varying amounts, tumour-like lesions and carcinoma showed more of collagen fibres and less of ground substance. Elastosis and lymphoplasmacytic infiltrate were prominent features in carcinomas rather than in benign lesions. (+info)Pathologic, immunohistochemical, and molecular features of benign and malignant phyllodes tumors of the breast. (4/101)
The histologic distinction between benign and malignant Phyllodes tumors (PT) is often difficult and arbitrary. We analyzed a group of benign and malignant PT to determine whether specific histologic features and expression of Ki-67 and p53 could be useful in distinguishing benign PT from malignant tumors. We also determined whether deletions in Chromosome 3p at the FHIT and hMLH1 loci are common abnormalities in PT. Twenty PT were histologically classified as benign (7) or malignant (13). Seven of the malignant PT were low grade, and six were high grade. Ki-67 and p53 immunohistochemistry was performed on all tumors and analyzed for the stromal and for the epithelial component. PCR-based loss of heterozygosity analyses were performed with the following markers on Chromosome 3p: D3S1478 (3p21.2--21.3), D3S1289 (3p21.1--21.2), and D3S1295 (3p14.3--21.1). The distribution of immunoreactivity for Ki-67 was analyzed by quantifying the percentage of positive nuclei and expressed as the labeling index (LI). Patients' ages ranged from 13 to 71 years (median: 51 y). After a mean follow-up period of 8 years, none of the PT metastasized, whereas three recurred locally. Although malignant PT were larger than benign PT (means, 7.1 versus 4.3 cm), this difference was not statistically significant. Five tumors had infiltrating margins, and 14 were circumscribed. The Ki-67 LI in low-grade malignant PT (16 +/- 25.5) was significantly higher than that in benign PT (3.6 +/- 4.8), whereas the LI in the high-grade malignant PT group (50 +/- 21.9) was significantly higher than that in low-grade malignant tumors (P =.012). The Ki-67 LI in the three tumors that recurred was less than 10%. Two of seven (29%) benign PT were focally positive for p53, whereas four of seven (57%) low-grade malignant and three of six (50%) high-grade malignant PT were diffusely positive for p53. The three tumors that recurred initially were histologically benign, as were two of the recurrences. One recurrent tumor evolved to a high-grade malignant PT. Margins were greater than 1 cm in all tumors except four, three of which recurred locally. No allelic loss of 3p was found. In summary, Ki-67 expression may assist in distinguishing benign from malignant PT in diagnostically difficult cases. 3p deletions do not play a significant role in the development of these tumors. Neither Ki-67 nor p53 can reliably predict recurrence. Histologically high-grade malignant PT have a favorable prognosis if widely excised. We emphasize the importance of adequate margins in the treatment of benign and malignant PT. (+info)Gray scale sonography of breast masses in adolescent girls. (5/101)
OBJECTIVE: To assess the sonographic findings of breast masses in adolescents and the usefulness of sonographic patterns for suggesting a specific diagnosis. METHODS: The sonograms and medical records of 57 girls (mean age, 15.4 years) with palpable breast masses were retrospectively reviewed. Three observers reviewed the sonograms for multiple sonographic findings. Surgery or clinical findings established diagnoses. Statistical analysis was done to determine how well sonographic findings alone and in combination agreed with final histologic diagnoses. RESULTS: Diagnoses included cysts (n = 12), abscesses (n = 7), fibroadenomas (n = 36), a lactating adenoma (n = 1), and a phyllodes tumor (n = 1). The sonographic findings varied significantly among lesion types (P < or = .005). CONCLUSIONS: Our experience suggests that virtually all breast masses in a pediatric population are benign and that sonography has the ability to differentiate among cystic, inflammatory, and solid masses. (+info)Phyllodes tumours. (6/101)
Phyllodes tumours are rare fibroepithelial lesions that account for less than 1% of all breast neoplasms. With the non-operative management of fibroadenomas widely adopted, the importance of phyllodes tumours today lies in the need to differentiate them from other benign breast lesions. All breast lumps should be triple assessed and the diagnosis of a phyllodes tumour considered in women, particularly over the age of 35 years, who present with a rapidly growing "benign" breast lump. Treatment can be by either wide excision or mastectomy provided histologically clear specimen margins are ensured. Nodal metastases are rare and routine axillary dissection is not recommended. Few reliable clinical and histological prognostic factors have been identified. Local recurrence occurs in approximately 15% of patients and is more common after incomplete excision. It can usually be controlled by further surgery. Repeated local recurrence has been reported without the development of distant metastases or reduced survival. Approximately 20% of patients with malignant phyllodes tumours develop distant metastases. Long term survival with distant metastases is rare. The role of chemotherapy, radiotherapy, and hormonal manipulation in both the adjuvant and palliative settings remain to be defined. (+info)Leiomyosarcoma of the female breast. (7/101)
Leiomyosarcomas of the breast are rare tumors. Less than 15 such cases have been reported in the literature so far. In this paper authors describe a case of leiomyosarcoma of a female breast presenting as a firm lobulated mass, mimicking a phylloid tumor radiographically. By fine needle aspiration biopsy, on the smears discohesive malignant looking cells were conclusive to a poorly differentiated invasive ductal carcinoma of the breast. The mastectomy specimen contained a lobulated mass, microscopically showing a partly epithelioid spindle cell tumor, immunoreactive for vimentin, desmin, smooth muscle actin antibodies, and negative for epithelial markers, hormone and growth factor receptors. Axillary lymph nodes were free of tumor. A primary leiomyosarcoma of the breast was diagnosed. (+info)Proliferating activity in differential diagnosis of benign phyllodes tumor and cellular fibroadenomas: is it helpful? (8/101)
Benign phyllodes tumors and fibroadenomas are two types of fibroepithelial tumors of breast that are usually difficult to differentiate. The purpose of this study is to evaluate the proliferative activity of these tumors and to find out if it helps in differential diagnosis. Thirty-one benign phyllodes tumors and twelve cellular fibroadenomas were retrieved from the archives of Pathology Department of Akdeniz University, School of Medicine. Proliferating activity of epithelial and stromal cells were evaluated by using labeling index (LI) of proliferating cell nuclear antigen (PCNA) and Ki-67 antigen by immunohistochemistry. The results were compared with other clinicopathologic findings. There was not any significant difference between the proliferating activity of phyllodes tumor and cellular fibroadenomas. Mean LI of PCNA was 28.01 (+/-22.85) in stromal cells and 56.57 (+/-30.98) in epithelial cells of phyllodes tumor where it was 28.92 (+/-24.02) and 62.53 (+/-32.56) in fibroadenomas. Ki-67 indices were 0.05 (+/-0.19) in stromal cells, 2.65 (+/-12.53) in epithelial cells of phyllodes tumors and 0.0 (+/-0) in stromal cells, 0.43 (+/-0.63) in epithelial cells of fibroadenomas. There was no correlation between the diameter of tumors and proliferating activity in both groups. Proliferating activity, determined by immunohistochemistry with PCNA and Ki-67 antibodies did not reveal significant difference between phyllodes tumor and fibroadenoma. (+info)A Phyllodes tumor is a rare type of breast tumor that originates from the connective tissue (stroma) that supports the breast lobules and ducts. These tumors can be benign, borderline, or malignant, depending on their level of invasiveness and cellular atypia.
Phyllodes tumors are typically large, firm, and well-circumscribed masses with a leaf-like (phyllode) internal architecture. They can grow quickly and may cause symptoms such as pain, swelling, or a palpable lump in the breast. Surgical excision is the primary treatment for Phyllodes tumors, and the extent of surgery depends on the tumor's size, grade, and margins. Regular follow-up is necessary to monitor for recurrence.
A fibroadenoma is a benign (noncancerous) breast tumor that is most commonly found in women between the ages of 15 and 35, although it can occur at any age. It is composed of glandular and connective tissue. The tumor typically feels firm, smooth, and rubbery, and its size may vary from quite small to over 2 inches in diameter.
Fibroadenomas are usually mobile within the breast tissue, which means they can be moved around easily when touched. They can occur as a single lump or multiple lumps (known as fibroadenomatosis). The exact cause of fibroadenomas is not known, but hormonal factors may play a role in their development.
Fibroadenomas are generally not painful, although some women may experience discomfort or tenderness, especially before their menstrual period. In most cases, fibroadenomas do not require treatment and can be monitored with regular breast exams and imaging studies such as mammography or ultrasound. However, if a fibroadenoma grows larger or becomes uncomfortable, it may be removed through a surgical procedure.
Fibroepithelial neoplasms are benign (non-cancerous) growths that consist of both fibrous and epithelial tissue. These types of neoplasms can occur in various parts of the body, but they are most commonly found in the skin and mucous membranes. A well-known example of a fibroepithelial neoplasm is a skin tag (acrochordon). Other examples include fibroma, papilloma, and neurofibroma.
Fibroepithelial neoplasms are typically slow-growing and cause little to no discomfort or symptoms. However, they may be removed for cosmetic reasons or if they become irritated, inflamed, or start to bleed. In rare cases, a fibroepithelial neoplasm can undergo malignant transformation and develop into cancer. It is essential to have any new or changing growths evaluated by a healthcare professional to determine the appropriate course of action.
Adenofibroma is a rare, benign tumor that occurs most commonly in the salivary glands. It is composed of both glandular tissue (adeno-) and fibrous tissue (-fibroma). These tumors are slow-growing and typically do not spread to other parts of the body.
Adenofibromas can also occur in other areas of the body, such as the skin, where they may be referred to as "fibroepithelial polyps" or "skin tags." In general, adenofibromas are not cancerous and can often be removed surgically. However, it is important to have any new growths or lumps evaluated by a healthcare professional to determine the appropriate course of treatment.
A simple mastectomy, also known as a total mastectomy, is a surgical procedure that involves the removal of the entire breast tissue, including the nipple and areola, but does not include the removal of the lymph nodes or muscles in the chest wall. This type of mastectomy may be recommended for patients with early-stage breast cancer, large tumors, or multiple tumors in one breast, as well as those who have a high risk of developing breast cancer due to genetic factors.
The goal of a simple mastectomy is to remove the cancerous tissue while preserving as much healthy tissue as possible. This procedure may be performed as a preventative measure for individuals at high risk of developing breast cancer, or as a treatment option for those diagnosed with breast cancer. It's important to note that a simple mastectomy does not involve the removal of axillary lymph nodes, which are typically removed in a modified radical mastectomy for patients with breast cancer that has spread to the lymph nodes.
After the procedure, patients may require reconstructive surgery to rebuild the shape and appearance of the breast. It's essential for patients to discuss their options with their healthcare provider to determine the best course of treatment based on their individual needs and circumstances.
Breast neoplasms refer to abnormal growths in the breast tissue that can be benign or malignant. Benign breast neoplasms are non-cancerous tumors or growths, while malignant breast neoplasms are cancerous tumors that can invade surrounding tissues and spread to other parts of the body.
Breast neoplasms can arise from different types of cells in the breast, including milk ducts, milk sacs (lobules), or connective tissue. The most common type of breast cancer is ductal carcinoma, which starts in the milk ducts and can spread to other parts of the breast and nearby structures.
Breast neoplasms are usually detected through screening methods such as mammography, ultrasound, or MRI, or through self-examination or clinical examination. Treatment options for breast neoplasms depend on several factors, including the type and stage of the tumor, the patient's age and overall health, and personal preferences. Treatment may include surgery, radiation therapy, chemotherapy, hormone therapy, or targeted therapy.
Stromal cells, also known as stromal/stroma cells, are a type of cell found in various tissues and organs throughout the body. They are often referred to as the "connective tissue" or "supporting framework" of an organ because they play a crucial role in maintaining the structure and function of the tissue. Stromal cells include fibroblasts, adipocytes (fat cells), and various types of progenitor/stem cells. They produce and maintain the extracellular matrix, which is the non-cellular component of tissues that provides structural support and biochemical cues for other cells. Stromal cells also interact with immune cells and participate in the regulation of the immune response. In some contexts, "stromal cells" can also refer to cells found in the microenvironment of tumors, which can influence cancer growth and progression.
A "large-core needle biopsy" is a medical procedure in which a large-bore needle is used to obtain a tissue sample from the body for diagnostic examination. This type of biopsy allows for the removal of a larger piece of tissue than what can be obtained with a fine-needle aspiration biopsy, and it is often used when a mass or abnormality can be felt during a physical exam.
During the procedure, the healthcare provider will use imaging guidance (such as ultrasound, CT scan, or MRI) to help guide the needle into the appropriate location. Once the needle is in place, it is advanced into the mass or abnormality and a core of tissue is removed for analysis. The sample is then sent to a laboratory where a pathologist will examine the tissue under a microscope to determine if there are any abnormal cells present that may indicate cancer or other diseases.
Large-core needle biopsies are generally considered safe, but like all medical procedures, they do carry some risks, such as bleeding, infection, and discomfort at the biopsy site. Patients should discuss any concerns with their healthcare provider before undergoing the procedure.
Tumor markers are substances that can be found in the body and their presence can indicate the presence of certain types of cancer or other conditions. Biological tumor markers refer to those substances that are produced by cancer cells or by other cells in response to cancer or certain benign (non-cancerous) conditions. These markers can be found in various bodily fluids such as blood, urine, or tissue samples.
Examples of biological tumor markers include:
1. Proteins: Some tumor markers are proteins that are produced by cancer cells or by other cells in response to the presence of cancer. For example, prostate-specific antigen (PSA) is a protein produced by normal prostate cells and in higher amounts by prostate cancer cells.
2. Genetic material: Tumor markers can also include genetic material such as DNA, RNA, or microRNA that are shed by cancer cells into bodily fluids. For example, circulating tumor DNA (ctDNA) is genetic material from cancer cells that can be found in the bloodstream.
3. Metabolites: Tumor markers can also include metabolic products produced by cancer cells or by other cells in response to cancer. For example, lactate dehydrogenase (LDH) is an enzyme that is released into the bloodstream when cancer cells break down glucose for energy.
It's important to note that tumor markers are not specific to cancer and can be elevated in non-cancerous conditions as well. Therefore, they should not be used alone to diagnose cancer but rather as a tool in conjunction with other diagnostic tests and clinical evaluations.
Immunohistochemistry (IHC) is a technique used in pathology and laboratory medicine to identify specific proteins or antigens in tissue sections. It combines the principles of immunology and histology to detect the presence and location of these target molecules within cells and tissues. This technique utilizes antibodies that are specific to the protein or antigen of interest, which are then tagged with a detection system such as a chromogen or fluorophore. The stained tissue sections can be examined under a microscope, allowing for the visualization and analysis of the distribution and expression patterns of the target molecule in the context of the tissue architecture. Immunohistochemistry is widely used in diagnostic pathology to help identify various diseases, including cancer, infectious diseases, and immune-mediated disorders.
Phyllodes tumor
Parotid gland
Breast disease
Fibroadenoma
Metastatic breast cancer
MED12
Metaplastic carcinoma
Breast cancer
Fibroepithelial neoplasm
Papillary hidradenoma
SDHB
Phyllodes
Aggressive fibromatosis
Male breast cancer
List of cancer types
Lactiferous duct
List of MeSH codes (C17)
Index of oncology articles
List of MeSH codes (C04)
Papillomatosis of breasts
Kodaganur S. Gopinath
International Classification of Diseases for Oncology
Eve Wiltshaw
PAX3
Phyllodes tumor - Wikipedia
Phyllodes Tumor of Breast: A Review Article
Phyllodes Tumor (Cystosarcoma Phyllodes) Workup: Laboratory Studies, Imaging Studies, Biopsy
Surgery for Phyllodes Breast Tumors Varies Widely | MedPage Today
Phyllodes Tumors of the Breast - Diagnostic and Therapeutic Dilemmas | Onkologie | Karger Publishers
Phyllodes Tumor…anyone else? - Breastcancer.org
Malignant phyllodes tumor | Radiology Reference Article | Radiopaedia.org
Phyllodes Tumor - Gynecology and Obstetrics - MSD Manual Professional Edition
Phyllodes Tumors of the Breast: Natural History, Diagnosis, and Treatment in: Journal of the National Comprehensive Cancer...
Pediatric Breast Disorders: Background, Embryology and Breast Development, Congenital Breast Anomalies
Benign phyllodes tumor of the vulva: A case report and literature review - Fingerprint - Penn State
Phyllodes Tumors recommended foods Archives | addon.life
malignant phyllodes tumor
Phyllodes tumor in an adolescent female | International Surgery Journal
PHYLLODES TUMOR OF THE BREAST : A CLINICOPATHOLOGICAL ANALYSIS FROM A SINGLE INSTITUTION
MALIGNANT PHYLLODES TUMOUR OF THE BREAST | Journal of Ayub Medical College Abbottabad
Invasive lobular carcinoma arising in phyllodes tumor of the breast [2]<...
Phyllodes Tumors of the Breast | Sylvester Comprehensive Cancer Center | University of Miami Health System
Breast cancer types: Definitions, symptoms, treatments, and more
Breast Cancer: Symptoms, Stages, Types, and More
Simple Mastectomy: Overview, Periprocedural Care, Technique
Cancer Protocols
ER, p53 and MIB-1 are significantly associated with malignant phyllodes tumor - Fingerprint - Sultan Qaboos University...
Current clinical practice in the management of phyllodes tumors of the breast: an international cross-sectional study among...
Breast Cancer: Symptoms, Risk Factors, Diagnosis, Treatment, and Prevention
Skin Recurrence of a Phyllodes Tumor and Impact of Radiotherapy: A Case Report and Review of the Literature | Journal...
Dr. Antoaneta Mueller, MD, Obstetrics & Gynecology Specialist - Lakewood, CA | Sharecare
Health Library | Rutgers Cancer Institute of New Jersey
Rare Cancer Support Forum • Members
Rare Cancer Support Forum • Members
Recurrence12
- Surgical management is the mainstay and local recurrence in phyllodes tumours has been associated with inadequate local excision. (hindawi.com)
- Accurate preoperative pathological diagnosis allows correct surgical planning and avoidance of reoperation, either to achieve wider excision or for subsequent tumor recurrence [ 8 - 10 ]. (hindawi.com)
- It has been suggested that, in a proportion of fibroadenomas, a somatic mutation can result in a monoclonal proliferation, histologically indistinguishable from the polyclonal element, but with a propensity to local recurrence and progression to a phyllodes tumor which has also been supported by clonal analysis. (hindawi.com)
- Wide surgical margins did not reduce local recurrence of phyllodes breast tumors, and re-excision of negative margins for benign tumors offered no apparent benefits, according to a review of 550 cases. (medpagetoday.com)
- However, adequate margin width remains controversial, as some series have suggested that a tumor-free margin is sufficient to prevent local recurrence. (medpagetoday.com)
- Although wide local excision is usually the treatment of choice, tumor recurrence is common. (karger.com)
- The prognosis of phyllodes tumors is favorable, with local recurrence occurring in approximately 15% of patients overall and distant recurrence in approximately 5% to 10% overall. (jnccn.org)
- Local recurrence of benign, borderline, and malignant phyllodes tumors of the breast: a systematic review and meta-analysis. (ijsurgery.com)
- As medical knowledge of tumor biology has grown, surgeons have come to realize that combining surgical treatment with adjuvant treatments such as chemotherapy, radiotherapy, hormone therapy, and immunotherapy allows better control of the cancer and results in higher disease-free survival and local recurrence rates. (medscape.com)
- Risk factors for recurrence and death after primary surgical treatment of malignant phyllodes tumors. (neoplasiaresearch.com)
- Phyllodes tumor of the breast: Stromal overgrowth and histological classification are useful prognosis-predictive factors for local recurrence in patients with a positive surgical margin. (neoplasiaresearch.com)
- Phyllodes Tumors - The predictors of recurrence (Patlas M, Ed.). Canadian Association of Radiology Journal. (ohri.ca)
Cystosarcoma6
- They were previously termed cystosarcoma phyllodes, coined by Johannes Muller in 1838, before being renamed to phyllodes tumor by the World Health Organization in 2003. (wikipedia.org)
- Fiks A . Cystosarcoma phyllodes of the mammary gland-Muller's tumor. (jnccn.org)
- Cystosarcoma phyllodes of the breast: a malignant and benign tumor. (jnccn.org)
- It is also known as cystosarcoma phyllodes/ serocystic disease of Brodie. (ijsurgery.com)
- Cystosarcoma phyllodes: treatment by subcutaneous mastectomy with immediate prosthetic implantation. (ijsurgery.com)
- Primary treatment of cystosarcoma phyllodes of the breast. (neoplasiaresearch.com)
Tumours4
- Phyllodes tumours are rare fibroepithelial lesions. (hindawi.com)
- The preoperative diagnosis and proper management are crucial in phyllodes tumours because of their tendency to recur and malignant potential in some of these tumours. (hindawi.com)
- The International Agency for Research on Cancer (IARC) has launched a new website dedicated to the Mapping the Evidence for the World Health Organization (WHO) Classification of Tumours: a Living Evidence Gap Map by Tumour Type (WCT EVI MAP) project. (who.int)
- The first article, "Phyllodes tumour evidence gaps mapped from the 5th edition of the WHO Classification of Tumours of the Breast", is the first-ever publication of an evidence gap map from a WHO Blue Book, the volume on tumours of the breast. (who.int)
Excision4
- Wide excision with tumor-free margins was carried out in 29 (80.5%) cases and mastectomy in 7 (19.4%) cases. (karger.com)
- Usual treatment of a phyllodes tumor is wide excision, but a mastectomy may be more appropriate if the mass is large or histology suggests cancer. (msdmanuals.com)
- Most phyllodes tumors are benign and are treated with surgical excision alone. (umiamihealth.org)
- Most agreed to recommend a tumor -free excision margin for benign tumors , increasing margins for borderline and malignant tumors . (bvsalud.org)
Surgical5
- [ 29 ] Adam et al concluded that the surgical margin should be at least 5 mm regardless of tumor grade. (medscape.com)
- Surgical management of phyllodes tumors. (ijsurgery.com)
- Surgical treatment of phyllodes tumors of the breast: Retrospective review of 172 cases. (neoplasiaresearch.com)
- Is the extent of surgical resection important in patient outcome in benign and borderline phyllodes tumors of the breast? (tubitak.gov.tr)
- Scores for tumor size, surgical margin, and pathologic classification are added to produce a total VNPI score of 3 to 9, with increasing scores representing a progressively worse prognosis. (medscape.com)
Cases of phyllodes tumors2
- Contemporary multi-institutional cohort of 550 cases of phyllodes tumors (2007-2017) demonstrates a need for more individualized margin guidelines. (msdmanuals.com)
- In two years 11 cases of phyllodes tumors were identified, the age range was between 33 to 66 years old, mean 45.9. (bvsalud.org)
Treatment of phyllodes tumors1
- Background: This article compares experiences in the diagnosis and treatment of phyllodes tumors from 2 regional institutions with the relevant literature. (karger.com)
Management of phyllodes tumors2
- Current clinical practice in the management of phyllodes tumors of the breast: an international cross-sectional study among surgeons and oncologists. (bvsalud.org)
- We conducted a cross-sectional survey of surgeons and oncologists with the aim to describe current clinical practice in the management of phyllodes tumors . (bvsalud.org)
Exact etiology of phyllodes2
- Experts are unsure of the exact etiology of phyllodes tumors. (wikipedia.org)
- At present time, the exact etiology of phyllodes tumor and its relationship with fibroadenoma are unclear. (hindawi.com)
Fibroadenoma or a phyllodes tumor2
- Clinically, rare cases of PASH present as a well-circumscribed, dense, rubbery mass mimicking a fibroadenoma or a phyllodes tumor. (health.am)
- However, there is some increased risk if it's a complex fibroadenoma or a phyllodes tumor. (rockymountaincancercenters.com)
Diagnosis of phyllodes2
- The value of FNAC in diagnosis of phyllodes tumour remains controversial, but core needle biopsy has high sensitivity and negative predictive value. (hindawi.com)
- Fine-needle aspiration (FNA) for cytologic examination usually is inadequate for the diagnosis of phyllodes tumors. (medscape.com)
Mammographic and sonographic1
- Benign and malignant phyllodes tumors: mammographic and sonographic findings. (radiopaedia.org)
Angiosarcoma2
- Examples of sarcomas that can occur in the breast include phyllodes tumor and angiosarcoma. (mayoclinic.org)
- In the differential diagnosis of ASC it is important to exclude angiosarcoma, phyllodes tumor and metastatic sarcomas to the breast. (prolekare.cz)
Papillary1
- Phullon, which means 'leaf' in Greek, describes the unique papillary projections characteristic of phyllodes tumors on histology. (wikipedia.org)
Necrosis2
- In 1981 [ 6 ] the World Health Organization adopted the term phyllodes tumor and as described by Rosen [ 7 ] subclassified them histologically as benign, borderline, or malignant according to the features such as tumor margins, stromal overgrowth, tumor necrosis, cellular atypia, and number of mitosis per high power field. (hindawi.com)
- Distended duct with intact basement membrane and central tumor necrosis. (medscape.com)
Recur2
- Between 20% and 35% of these tumors recur locally, and distant metastases occur in 10 to 20% of patients. (msdmanuals.com)
- As most tumors recur within 2 years of diagnosis, we propose a close clinical and imaging follow-up during this period. (tubitak.gov.tr)
Radiotherapy3
- Adjuvant radiotherapy for phyllodes tumor of breast. (ijsurgery.com)
- Phyllodes tumor, Radiotherapy. (neoplasiaresearch.com)
- Utilization of radiotherapy for malignant phyllodes tumors: analysis of the National Cancer Data Base, 1998-2009. (asbestos.com)
Core-needle biopsy2
- A core needle biopsy is the primary tool used to provide a definitive diagnose for a phyllodes tumors. (wikipedia.org)
- All underwent core needle biopsy that inform suspected phyllodes in 8 of 11 cases, in 2 cases they reported a fibroadenoma. (bvsalud.org)
Epithelial7
- Phyllodes tumors (from Greek: phullon), are a rare type of biphasic fibroepithelial mass that form from the periductal stromal and epithelial cells of the breast. (wikipedia.org)
- The current theory behind the development of phyllodes tumors involves the interaction between each of these pathways to some degree and how they alter the normal interaction of the breast epithelial-stromal tissue. (wikipedia.org)
- Phyllodes tumors may be considered benign, borderline, or malignant depending upon their histological features, including stromal cellularity, infiltration of the epithelial-stromal interface, and mitotic activity. (wikipedia.org)
- The term phyllodes tumor represents a broad range of fibroepithelial diseases and presence of an epithelial component with stromal components differentiates the phyllodes tumor from other stromal sarcomas. (hindawi.com)
- This fibro-epithelial lesion occurs in less than 1% of all breast tumors in female. (ijsurgery.com)
- HER-2/neu oncogene amplification by fluorescence in situ hybridization in epithelial tumors of the ovary. (nih.gov)
- Breast cancers usually are epithelial tumors of ductal or lobular origin. (medscape.com)
Mastectomy1
- Phyllodes tumors can be removed with mastectomy (removal of the whole breast with the tumor) or lumpectomy (removal of the tumor with a small amount of surrounding breast tissue) depending on the size and type of the tumor and patient preference. (umiamihealth.org)
Margins2
- Surgery is defined as the effective treatment for PT but patients with high risk factors as large tumor size, positive margins and recurrent disease adjuvant treatments must be added. (neoplasiaresearch.com)
- All underwent exeresis of the tumor where 2 cases were committed and required margins expanding margins, both were the reported as fibroadenoma. (bvsalud.org)
Investigating a malignant1
- A study investigating a malignant phyllodes tumor with whole genomic and proteomic analysis revealed chromosome mutations, amplifications, and deletions. (medscape.com)
Lesions6
- Phyllodes tumors are part of a group of breast diseases called cellular fibroepithelial lesions. (wikipedia.org)
- With the nonoperative management of fibroadenomas widely adopted, the importance of phyllodes tumors today lies in the need to differentiate them from other benign breast lesions. (hindawi.com)
- Although mammography and ultrasonography (US) generally are important in the diagnosis of breast lesions, they have not been reliable in differentiating benign phyllodes tumors from malignant phyllodes tumors or from fibroadenomas. (medscape.com)
- Open excisional breast biopsy for smaller lesions and incisional biopsy for large lesions are the definitive methods for diagnosing phyllodes tumors. (medscape.com)
- Phyllodes tumors account for fewer than 1% of all breast lesions. (medpagetoday.com)
- Phyllodes tumors of the breast are rare fibroepithelial lesions that are classified as benign, borderline or malignant. (bvsalud.org)
Average tumor2
- Phyllodes tumors can grow to a variety of sizes, ranging from 0.8 to 40 cm, with the average tumor growing to between 4 and 8 cm. (wikipedia.org)
- The average tumor size was 5.1 cm(range 1.4-19.6). (karger.com)
Stromal4
- It has also been postulated that stromal induction of phyllodes tumors can occur as a result of growth factors produced by the breast epithelium. (hindawi.com)
- [ 16 ] It has been suggested that stromal Ki67 expression may prove to be a useful marker for distinguishing benign phyllodes tumor of the breast from fibroadenoma. (medscape.com)
- All phyllodes tumors contain a stromal component that can vary significantly in histologic appearance from one lesion to another. (medscape.com)
- [ 26 ] with increased stromal cellularity and an increased mitotic count, is almost always observed in malignant phyllodes tumors. (medscape.com)
Adjuvant2
- Adjuvant radiation therapy improved local control in high grade tumors although it did not reach significance. (journalmedica.com)
- There were mixed opinions on adjuvant treatment , with a trend towards more liberal regiments in patients with locally advanced tumors . (bvsalud.org)
Metastatic1
- At one extreme, malignant phyllodes tumors, if inadequately treated, have a propensity for rapid growth and metastatic spread. (hindawi.com)
Fibroepithelial tumors3
- Phyllodes tumors of the breast are unusual fibroepithelial tumors that exhibit a wide range of clinical behavior. (jnccn.org)
- These neoplasms are a group of rare fibroepithelial tumors of the breast, accounting for 0.3-1.0% of breast tumors. (bvsalud.org)
- Phyllodes tumors are a group of rare fibroepithelial tumors of the breast, accounting for 0.3-1.0% of all breast tumors (5, 6). (bvsalud.org)
Benign fibroadenoma3
- None of these imaging tools are definitive tests for differentiating a phyllodes tumor from a benign fibroadenoma. (wikipedia.org)
- This term incorporates a spectrum of diseases ranging from a benign fibroadenoma to a malignant phyllodes tumor, with numerous variants in between. (wikipedia.org)
- To distinguish a phyllodes tumor of a fibroadenoma through physical examination is extremely difficult, a core biopsy can accurately diagnose most diseases of the breast (16, 17), but may be inconclusive to differentiate a benign fibroadenoma of a phyllodes tumor. (bvsalud.org)
Prognosis1
- influence the prognosis of Phyllodes tumour. (edu.pk)
Clinical3
- In contrast, benign phyllodes tumors on clinical, radiological, and cytological examination are often indistinguishable from fibroadenomas and can be cured by local surgery. (hindawi.com)
- The aim of our study is to examine the clinical and pathological features of patients with breast phyllodes tumors and to determine features that are correlated to outcome. (journalmedica.com)
- This study shows considerable variation in clinical practice managing phyllodes tumors . (bvsalud.org)
Histologic features1
- These tumors are categorized as benign, borderline, or malignant based on a combination of histologic features. (jnccn.org)
Typically present as a firm2
- Phyllodes tumors typically present as a firm, mobile, and palpable mass that is painless in nature. (wikipedia.org)
- These tumors typically present as a firm, painless mass in the breast, and some may grow quickly. (umiamihealth.org)
Breast tumor1
- Phyllodes tumor is a nonepithelial breast tumor that may be benign or malignant. (msdmanuals.com)
Diagnoses2
- Based on actual cases drawn from the extensive breast pathology consultation practice at Vanderbilt University Medical Center, Breast Pathology covers the full classification of breast tumors and focuses on especially challenging differential diagnoses or unusual and problematic morphologic presentations. (credoreference.com)
- Review of recent reported cases of NICTH identified widespread anatomic locations and varied pathologic diagnoses of tumors associated with paraneoplastic production of IGF-2 causing hypoglycemia. (medscape.com)
Differentiate1
- A retrospective study by Kawashima et al suggested that intravoxel incoherent motion (IVIM) MRI could differentiate phyllodes tumors from fibroadenomas by comparing the apparent diffusion coefficient (ADC) values. (medscape.com)
Fibroadenomas3
- [ 21 ] The study included seven fibroadenomas and 15 phyllodes tumors (10 benign, four borderline, and one malignant). (medscape.com)
- Multiple types of non-cancerous breast conditions exist, including fibrocystic breast changes, breast cysts, fibroadenomas, and benign breast tumors. (rockymountaincancercenters.com)
- Phyllodes tumors are made of similar tissue that creates fibroadenomas, but under a microscope the phyllodes tumor looks a bit different. (rockymountaincancercenters.com)
Cancers2
- Hereditary breast cancers tend to develop earlier in life than noninherited (sporadic) cases, and new (primary) tumors are more likely to develop in both breasts. (medlineplus.gov)
- Cancers occur when a buildup of mutations in critical genes-those that control cell growth and division or repair damaged DNA-allow cells to grow and divide uncontrollably to form a tumor . (medlineplus.gov)
Described as benign1
- The majority of phyllodes tumors have been described as benign (35% to 64%), with the remainder divided between the borderline and malignant subtypes. (hindawi.com)
Lymph nodes1
- Because phyllodes tumors rarely spread to lymph nodes, lymph node evaluation is usually not performed at the time of surgery. (umiamihealth.org)
Pathologic2
- The primary purpose of this study is to determine whether breast cancer tumors respond (as measured by pathologic complete response: the absence of microscopic evidence of invasive tumor cells in the breast) to combined chemotherapy of AC(doxorubicin and cyclophosphamide) followed by paclitaxel plus trastuzumab or lapatinib or both given before surgery to patients with HER2-positive breast cancer. (stanford.edu)
- Also, the study will look at whether there are gene expression profiles in the tumor tissue that can predict pathologic complete response. (stanford.edu)
Borderline or malignant1
- i've completely blown the "don't google" protocol that i'd set for myself and i'm afraid of my own phone and have no idea how to prepare for what could be at least three or four different scenarios ranging from fibroadenoma (seems extremely unlikely at this point) to benign phyllodes or borderline or malignant and maybe even, from the looks of what i'm reading. (breastcancer.org)
Overgrowth2
- tumor or neoplasm is a mass that is generally harmless, as this is an overgrowth of normal tissue. (dummies.com)
- cancerous) tumor is bad news, as this is an overgrowth of mutated tissue. (dummies.com)
Genetically2
- Genetically, phyllodes tumors have shown to have a higher incidence with conditions such as Li-Fraumeni syndrome and BRCA1/BRCA2 mutations. (wikipedia.org)
- The second direction is to have the tumor itself genetically tested, and see if there is a drug that's tailored to those genes. (robinwood.com)
Rare12
- i don't want to harrass my surgeon and call and call and ask the same unanswerable questions but it really scares me that so little seems to be understood about phyllodes and that it IS so rare. (breastcancer.org)
- Recurrent giant phyllodes tumour in a 17-year-old female: a rare case report. (ijsurgery.com)
- Makar GS, Makar M, Ghobrial J, Bush K, Gruner RA, Holdbrook T. Malignant phyllodes tumor in an adolescent female: A rare case report and review of the literature. (ijsurgery.com)
- Background: Malignant Phyllodes Tumour (MPT) is considered to be a rare disease of the breast. (edu.pk)
- Phyllodes tumors are a rare type of tumor that develops in the connective tissues of the breast. (umiamihealth.org)
- This rare tumor is usually slow-growing and often mistaken for other types. (webmd.com)
- The tumors in this rare type are a soft, squishy mass that looks like part of your brain called the medulla. (webmd.com)
- Tumors in this rare type float in a pool of mucin, part of the slippery, slimy stuff that makes up mucus. (webmd.com)
- These rare tumors grow in a leaflike pattern. (webmd.com)
- Phyllodes tumors (PTs) are rare and are usually associated with local recurrences. (neoplasiaresearch.com)
- Phyllodes tumour is a rare breast condition. (cancervic.org.au)
- Background/aim: Phyllodes tumors (PTs) of the breast are rare, and their diagnosis and treatment remain controversial. (tubitak.gov.tr)
Recurrent1
- Recurrent Phyllodes tumour. (edu.pk)
Tissue5
- Despite their propensity to grow rapidly and deform the overlying breast tissue, approximately 20% of phyllodes tumors can present as a nonpalpable mass on screening mammography. (wikipedia.org)
- Because no tumor has a single mutation, genomic profiling allows the pathologist (cellular expert) to identify groups of mutations in your tumor tissue sample. (umiamihealth.org)
- This procedure removes a tumor (lump) and a small amount of normal tissue around it. (umiamihealth.org)
- During a lumpectomy, your surgeon removes the tumor and a small area of surrounding tissue. (umiamihealth.org)
- Using a tissue sample from your breast biopsy or using your tumor if you've already undergone surgery, your medical team determines your breast cancer type. (mayoclinic.org)
Metastases1
- Bladder Tumors with Multiple Cardiac Metastases, with Elevated Serum Granulocyte Colony-Stimulating Factor. (amedeo.com)
Occur1
- When hypoglycemia does occur in such individuals, an uncommon but important diagnosis to consider is non-islet cell tumor hypoglycemia (NICTH). (medscape.com)
Prognostic2
- Conclusion: Our study shows that tumor size, margin infiltration, mitotic activity and degree of cellular atypia are important prognostic factors. (karger.com)
- Spatial relationship of tertiary lymphoid structures and tumor-associated neutrophils in bladder cancer and prognostic potential for anti-PD-L1 immunotherapy. (amedeo.com)
Medullary1
- Tumors of medullary carcinomas are soft and fleshy. (medicalnewstoday.com)
Retrospective1
- A small (N = 12) single-institution retrospective study by Johnson et al reported disproportionate rates of aggressive histopathologic features among Black women with phyllodes tumor as compared with non-Black women. (medscape.com)
Distinguish1
- A study by Niu et al suggested that the application of artificial intelligence to quantitative analysis of data from US could improve the ability to distinguish between phyllodes tumor and fibroadenoma. (medscape.com)
Cancer9
- Patients and Methods: From 1991 to 2005, 2,848 breast cancer patients were treated in our institutions, 36 (1.44%) for phyllodes tumors. (karger.com)
- but no, she found it, then came the diagnostic mammogram, then the ultrasound, then the call that the results were inconclusive, then an appointment for a biopsy, then a week of waiting, then a call from the surgeon who'd performed the biopsy saying that it wasn't "a breast cancer" but that it could be a phyllodes tumor and therefore (possibly) cancer in my breast. (breastcancer.org)
- Introduction Foods for Phyllodes Tumors should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. (addon.life)
- The CAP Cancer Protocols provide guidelines for collecting the essential data elements for complete reporting of malignant tumors and optimal patient care. (cap.org)
- Non-cancer breast tumors are abnormal growths, but they do not spread outside of the breast. (cancer.org)
- A less common type of breast cancer called phyllodes tumor can start in the stroma. (cancer.org)
- Once you've been diagnosed with breast cancer, your doctor will review your pathology report and the results of any imaging tests to understand the specifics of your tumor. (mayoclinic.org)
- Patient and tumor characteristics associated with primary tumor resection in women with Stage IV breast cancer: analysis of 1988-2003 SEER data. (asbestos.com)
- Breast cancer is a disease in which certain cells in the breast become abnormal and multiply uncontrollably to form a tumor. (medlineplus.gov)
Malignant potential1
- Due to their propensity to metastasize and grow quickly, almost all phyllodes tumors are regarded as having malignant potential and treated accordingly. (wikipedia.org)