Plasma Substitutes
Hydroxyethyl Starch Derivatives
Hemodilution
Plasma
Bone Substitutes
Blood Substitutes
Factor XIII Deficiency
Factor XIII
SMN Complex Proteins
Hemostasis
Argon Plasma Coagulation
Polymer structure and solubility of deoxyhemoglobin S in the presence of high concentrations of volume-excluding 70-kDa dextran. Effects of non-s hemoglobins and inhibitors. (1/379)
Earlier observations indicated that volume exclusion by admixed non-hemoglobin macromolecules lowered the polymer solubility ("Csat") of deoxyhemoglobin (Hb) S, presumably by increasing its activity. In view of the potential usefulness of these observations for in vitro studies of sickling-related polymerization, we examined the ultrastructure, solubility behavior, and phase distributions of deoxygenated mixtures of Hb S with 70-kDa dextran, a relatively inert, low ionic strength space-filling macromolecule. Increasing admixture of dextran progressively lowered the Csat of deoxyHb S. With 12 g/dl dextran, a 5-fold decrease in apparent Csat ("dextran-Csat") was obtained together with acceptable sensitivity and proportionality with the standard Csat when assessing the effects of non-S Hb admixtures (A, C, and F) or polymerization inhibitors (alkylureas or phenylalanine). The volume fraction of dextran excluding Hb was 70-75% of total deoxyHb-dextran (12 g/dl) volumes. Electron microscopy showed polymer fibers and fiber-to-crystal transitions indistinguishable from those formed without dextran. Thus when Hb quantities are limited, as with genetically engineered recombinant Hbs or transgenic sickle mice, the dextran-Csat provides convenient and reliable screening of effects of Hb S modifications on polymerization under near-physiological conditions, avoiding problems of high ionic strength. (+info)Resetting of exaggerated tubuloglomerular feedback activity in acutely volume-expanded young SHR. (2/379)
One purpose of the present study was to evaluate the ability of 7-wk-old spontaneously hypertensive rats (SHR) to reset tubuloglomerular feedback (TGF) activity in response to acute volume expansion (VE). Second, we evaluated the contribution of ANG II, via its action on AT1 receptors, to TGF control of glomerular function during VE. TGF was assessed by micropuncture methods and proximal tubular stop-flow pressure (SFP) determinations in SHR, Wistar-Kyoto rats (WKY), and Sprague-Dawley rats (SD). During euvolemia SHR exhibited enhanced TGF activity. In the same animals acute VE was achieved by infusion of saline (5 ml. h-1. 100 g body wt-1). VE led to resetting of TGF in all three strains. Maximal SFP responses, elicited by a 30-40 nl/min loop of Henle perfusion rate, decreased from 19 to 12 mmHg in SHR and, on average, from 11 to 5 mmHg in WKY and SD (P < 0.001). Tubular flow rate producing a half-maximal response (turning point) shifted to higher flow rates during VE, from 12 to 14 nl/min in SHR and from 15 to 19 nl/min in WKY. Administration of the AT1 receptor blocker candesartan (0.05 mg/kg iv) during sustained VE decreased TGF-mediated reductions in SFP in SHR and slightly increased the turning point in WKY. Nevertheless, other parameters of TGF activity were unaffected by AT1 receptor blockade. In conclusion, young SHR possess the ability to reset TGF activity in response to VE to a degree similar to compensatory adjustments in WKY. However, TGF remains enhanced in SHR during VE. ANG II and its action on AT1 receptors are in part responsible for the exaggerated SFP responses in young SHR during VE. (+info)Influence of right atrial pressure on the cardiac pacemaker response to vagal stimulation. (3/379)
We have recently shown that the intrinsic rate response to an increase in right atrial pressure is augmented when cardiac muscarinic receptors are activated. This present study examines the cardiac pacemaker response to vagal stimulation at different values of right atrial pressure in isolated rat right atrium and in the rabbit heart in situ. In the rat atrium, when pressure was raised in steps from 2 to 10 mmHg, there was a progressive reduction in the response to vagal stimulation [40.5 +/- 7.2% reduction (mean +/- SE) at 8 mmHg, P < 0.01], which was independent of the level of vagal bradycardia, that persisted in the presence of the beta-adrenergic agonist isoproterenol. In barbiturate-anesthetized rabbits with cervical vagi cut and beta-adrenergic blockade, raising right atrial pressure approximately 2.5 mmHg by blood volume expansion reduced the bradycardia elicited by electrical stimulation of the peripheral end of the right vagus nerve (9.1 +/- 1.1% reduction, P < 0.0001). These results demonstrate that vagal bradycardia is modulated by the level of right atrial pressure and suggest that normally right atrial pressure may interact with cardiac vagal activity in the control of heart rate. (+info)Effect of 20% in vitro haemodilution with warmed buffered salt solution and cerebrospinal fluid on coagulation. (4/379)
We have conducted an in vitro coagulation study consisting of two separate groups of 20 subjects using the thrombelastograph. In the first group, haemodilution was performed with a physiological balanced salt solution similar to plasma, with the exception of calcium, and buffered to a normal pH (Plasmalyte B) at 37 degrees C on blood obtained from consenting volunteers. In the second group, a protein-poor body fluid (cerebrospinal fluid (CSF)) obtained from parturient patients undergoing spinal anaesthesia for Caesarean section was used as the diluent. There were statistically significant differences between the warmed Plasmalyte B treated samples and their untreated controls for all variables measured by the thrombelastograph, except for maximum amplitude, and between the CSF treated samples and their untreated controls for all variables. We conclude that electrolyte and acid-base composition of the diluent fluid had no effect on the observation that crystalloid haemodilution produces hypercoagulability. The marked increase in coagulability produced by addition of CSF cannot be explained on a simple haemodilution basis and confirms previous suggestions of the presence of a procoagulant factor in CSF. (+info)Pseudo-proteinuria following gelofusine infusion. (5/379)
Transient massive proteinuria following cardiopulmonary bypass surgery was observed. It was characterized and attributed to post-operative gelofusine infusion. Gelofusine was found to interfere with dye binding but not immunochemical assays of proteinuria. Proteinuria following gelofusine infusion may not reflect underlying glomerular pathology. (+info)Effect of intravenous saline, albumin, or hydroxyethylstarch on blood volume during combined ultrafiltration and hemodialysis. (6/379)
It is generally advocated to use saline or albumin infusions during symptomatic hypotension during dialysis. However, because of their side effects and/or costs, they are of limited use. Hydroxyethylstarch (HES), a synthetic colloid with a long-standing volume effect, is used in the management of hypovolemia. In this study, the efficacy of three fluids (isotonic saline [0.9%], albumin [20%], and HES [10%]) was assessed during three treatment sessions with combined ultrafiltration and hemodialysis, which differed in the type of fluid given intravenously. Changes in relative blood volume (BV), systolic BP (SBP), and vascular reactivity (venous tone [VT]) were compared. An intravenous infusion of 100 ml of fluid was given when the decrease in BV versus baseline was more than 10% as measured by a continuous optical reflection method. The ultrafiltration was continued. BV decreased significantly versus baseline independent of the intravenous fluid administration in all three treatment sessions. However, when we compared BV values at the end of the dialysis session with those at the time of infusion, BV continued to decrease significantly with saline (change in BV -4.56 +/- 2.75%; P < 0.05) and albumin (change in BV -2.13 +/- 2.51%; P < 0.05), but not with HES (change in BV -0.15 +/- 2.17%; NS). Between albumin and HES there were no significant differences in changes in BV (NS), whereas between HES and saline (P < 0.05) and between albumin and saline (P < 0.05) the differences in BV changes were significant. SBP remained unchanged within each session. Although SBP tended to decrease more with saline compared to albumin and HES, the difference was not significant. The higher decrease in BV and SBP with saline was counterbalanced by a significantly higher increase in VT, while VT remained unchanged in the other two sessions. It is concluded that HES is a promising fluid in preserving blood volume, comparable to albumin, but superior to saline. (+info)Plasma volume expansion with solutions of hemoglobin, albumin, and Ringer lactate in sheep. (7/379)
We have measured plasma volume expansion (Evans blue and hematocrit changes) and hemodynamic responses in conscious hemorrhaged and normovolemic splenectomized sheep after a 30-min infusion of either 20 ml/kg of diaspirin cross-linked hemoglobin (DCLHb), 20 ml/kg of human albumin (Alb), or 60 ml/kg of a solution of Ringer lactate (RL). All regimens expanded blood volume and increased blood pressure and cardiac output after hemorrhage. However, only 15 +/- 3% of the infused volume of RL was evident as intravascular expansion 10-min postinfusion, compared with 67 +/- 16% and 139 +/- 139% for Alb and DCLHb, respectively. DCLHb infusions were associated with higher blood pressures and lower cardiac outputs compared with RL and Alb infusions, but the increased oxygen content of blood with DCLHb resulted in systemic delivery of oxygen similar to that of the other infusions. These differences in hemodynamics and vascular volume continued for 6 h, and at 24 h vascular volume and all hemodynamics were similar in all three groups. The better volume expansion with DCLHb may be due to greater mobilization of endogenous interstitial protein or reduced transcapillary loss as total intravascular endogenous plasma protein increased after infusion of DCLHb, whereas there was an apparent loss of endogenous intravascular protein after infusions of Alb and RL. Vasoconstriction by DCLHb is one mechanism that could lower blood-to-tissue transport of fluid and protein. In addition to its oxygen-carrying capacity and vasoactivity, DCLHb is associated with volume expansion properties out of proportion to its colloid osmotic pressure. (+info)Thrombelastogram reveals hypercoagulability after administration of gelatin solution. (8/379)
We have compared the effects of gelatin, low molecular weight hydroxyethyl starch (HES) or albumin on tests of haemostasis and on the thrombelastogram in 42 ASA I patients undergoing total hip or knee replacement. Patients were allocated randomly to receive one of the three blood substitutes to obtain moderate intraoperative haemodilution. Blood loss and packed red cell infusion was the same in each group. A greater amount of gelatin was given (1.5 times the measured blood loss) because of its shorter half-life. There was a statistically significant but clinically negligible decrease in platelets count, prothrombin time and fibrinogen, and an increase in bleeding time in all groups. Platelets were slightly but significantly lower after HES. Haemodilution was comparable between groups. TEG showed a state of hypercoagulability in the gelatin group with a significant decrease in r, r + k and an increase in alpha angle. (+info)Plasma substitutes are fluids that are used to replace the plasma volume in conditions such as hypovolemia (low blood volume) or plasma loss, for example due to severe burns, trauma, or major surgery. They do not contain cells or clotting factors, but they help to maintain intravascular volume and tissue perfusion. Plasma substitutes can be divided into two main categories: crystalloids and colloids.
Crystalloid solutions contain small molecules that can easily move between intracellular and extracellular spaces. Examples include normal saline (0.9% sodium chloride) and lactated Ringer's solution. They are less expensive and have a lower risk of allergic reactions compared to colloids, but they may require larger volumes to achieve the same effect due to their rapid distribution in the body.
Colloid solutions contain larger molecules that tend to stay within the intravascular space for longer periods, thus increasing the oncotic pressure and helping to maintain fluid balance. Examples include albumin, fresh frozen plasma, and synthetic colloids such as hydroxyethyl starch (HES) and gelatin. Colloids may be more effective in restoring intravascular volume, but they carry a higher risk of allergic reactions and anaphylaxis, and some types have been associated with adverse effects such as kidney injury and coagulopathy.
The choice of plasma substitute depends on various factors, including the patient's clinical condition, the underlying cause of plasma loss, and any contraindications or potential side effects of the available products. It is important to monitor the patient's hemodynamic status, electrolyte balance, and coagulation profile during and after the administration of plasma substitutes to ensure appropriate resuscitation and avoid complications.
Hydroxyethyl starch derivatives are modified starches that are used as plasma expanders in medicine. They are created by chemically treating corn, potato, or wheat starch with hydroxylethyl groups, which makes the starch more soluble and less likely to be broken down by enzymes in the body. This results in a large molecule that can remain in the bloodstream for an extended period, increasing intravascular volume and improving circulation.
These derivatives are available in different molecular weights and substitution patterns, which affect their pharmacokinetics and pharmacodynamics. They are used to treat or prevent hypovolemia (low blood volume) due to various causes such as bleeding, burns, or dehydration. Common brand names include Hetastarch, Pentastarch, and Voluven.
It's important to note that the use of hydroxyethyl starch derivatives has been associated with adverse effects, including kidney injury, coagulopathy, and pruritus (severe itching). Therefore, their use should be carefully monitored and restricted to specific clinical situations.
Hemodilution is a medical term that refers to the reduction in the concentration of certain components in the blood, usually referring to red blood cells (RBCs) or hemoglobin. This occurs when an individual's plasma volume expands due to the infusion of intravenous fluids or the body's own production of fluid, such as during severe infection or inflammation. As a result, the number of RBCs per unit of blood decreases, leading to a lower hematocrit and hemoglobin level. It is important to note that while hemodilution reduces the concentration of RBCs in the blood, it does not necessarily indicate anemia or blood loss.
In the context of medicine, plasma refers to the clear, yellowish fluid that is the liquid component of blood. It's composed of water, enzymes, hormones, antibodies, clotting factors, and other proteins. Plasma serves as a transport medium for cells, nutrients, waste products, gases, and other substances throughout the body. Additionally, it plays a crucial role in the immune response and helps regulate various bodily functions.
Plasma can be collected from blood donors and processed into various therapeutic products, such as clotting factors for people with hemophilia or immunoglobulins for patients with immune deficiencies. This process is called plasma fractionation.
Bone substitutes are materials that are used to replace missing or damaged bone in the body. They can be made from a variety of materials, including natural bone from other parts of the body or from animals, synthetic materials, or a combination of both. The goal of using bone substitutes is to provide structural support and promote the growth of new bone tissue.
Bone substitutes are often used in dental, orthopedic, and craniofacial surgery to help repair defects caused by trauma, tumors, or congenital abnormalities. They can also be used to augment bone volume in procedures such as spinal fusion or joint replacement.
There are several types of bone substitutes available, including:
1. Autografts: Bone taken from another part of the patient's body, such as the hip or pelvis.
2. Allografts: Bone taken from a deceased donor and processed to remove any cells and infectious materials.
3. Xenografts: Bone from an animal source, typically bovine or porcine, that has been processed to remove any cells and infectious materials.
4. Synthetic bone substitutes: Materials such as calcium phosphate ceramics, bioactive glass, and polymer-based materials that are designed to mimic the properties of natural bone.
The choice of bone substitute material depends on several factors, including the size and location of the defect, the patient's medical history, and the surgeon's preference. It is important to note that while bone substitutes can provide structural support and promote new bone growth, they may not have the same strength or durability as natural bone. Therefore, they may not be suitable for all applications, particularly those that require high load-bearing capacity.
Blood substitutes, also known as artificial blood or blood surrogates, are fluids that are designed to mimic some of the properties and functions of human blood. They are used as a replacement for blood transfusions in situations where blood is not available or when it is not safe to use. Blood substitutes can be divided into two main categories: oxygen-carrying and non-oxygen-carrying.
Oxygen-carrying blood substitutes contain artificial molecules called hemoglobin-based oxygen carriers (HBOCs) that are designed to carry oxygen from the lungs to the body's tissues. These HBOCs can be derived from human or animal hemoglobin, or they can be synthetically produced.
Non-oxygen-carrying blood substitutes, on the other hand, do not contain hemoglobin and are used primarily to restore intravascular volume and maintain blood pressure in cases of hypovolemia (low blood volume) caused by bleeding or dehydration. These products include crystalloids, such as saline solution and lactated Ringer's solution, and colloids, such as albumin and hydroxyethyl starch solutions.
It is important to note that while blood substitutes can be useful in certain situations, they are not a perfect substitute for human blood. They do not provide all of the functions of blood, such as immune defense and clotting, and their use is associated with some risks, including allergic reactions, kidney damage, and increased oxygen free radical production. Therefore, they should only be used when there is no suitable alternative available.
Factor XIII deficiency, also known as fibrin stabilizing factor deficiency, is a rare bleeding disorder caused by a lack or dysfunction of Factor XIII, a protein involved in the final stage of blood clotting. This deficiency results in impaired clot stability and increased risk of bleeding. Symptoms can include umbilical cord bleeding at birth, prolonged bleeding after circumcision, easy bruising, nosebleeds, muscle bleeds, gastrointestinal bleeds, and excessive menstrual bleeding. Treatment typically involves replacement of the missing Factor XIII through injections, either prophylactically or on-demand to manage bleeding episodes.
Factor XIII, also known as fibrin stabilizing factor, is a protein involved in the clotting process of blood. It is a transglutaminase enzyme that cross-links fibrin molecules to form a stable clot. Factor XIII becomes activated during the coagulation cascade, and its activity helps strengthen the clot and protect it from premature degradation by proteolytic enzymes. A deficiency in Factor XIII can lead to a bleeding disorder characterized by prolonged bleeding after injury or surgery.
The Survival Motor Neuron (SMN) complex is a protein complex that plays a crucial role in the biogenesis of small nuclear ribonucleoproteins (snRNPs), which are essential components of the spliceosome involved in pre-messenger RNA (pre-mRNA) splicing. The SMN complex consists of several proteins, including the SMN protein itself, Gemins2-8, and unrip.
The SMN protein is the central component of the complex and is encoded by the SMN1 gene located on chromosome 5q13.2. Mutations in this gene can lead to spinal muscular atrophy (SMA), a genetic disorder characterized by degeneration of motor neurons in the spinal cord, leading to muscle weakness and atrophy.
The SMN complex assembles in the cytoplasm and facilitates the assembly of spliceosomal snRNPs by helping to load Sm proteins onto small nuclear RNA (snRNA) molecules. Proper functioning of the SMN complex is essential for the correct splicing of pre-mRNA, and its dysfunction can lead to various developmental abnormalities and diseases, including SMA.
Hemostasis is the physiological process that occurs to stop bleeding (bleeding control) when a blood vessel is damaged. This involves the interaction of platelets, vasoconstriction, and blood clotting factors leading to the formation of a clot. The ultimate goal of hemostasis is to maintain the integrity of the vascular system while preventing excessive blood loss.
Argon Plasma Coagulation (APC) is a medical procedure that uses ionized argon gas to deliver electrical current and heat to tissue, resulting in coagulation. It is commonly used in the treatment of gastrointestinal bleeding, as well as for cutting and coagulating during surgical procedures. The argon plasma is created by passing argon gas through a high-voltage electrical field, which ionizes the gas and creates a highly precise and controllable plasma beam. This beam can be directed at the tissue to achieve hemostasis (stopping bleeding) or to cut tissue with minimal thermal damage to surrounding structures. The procedure is often performed under endoscopic guidance.
Blood coagulation, also known as blood clotting, is a complex process that occurs in the body to prevent excessive bleeding when a blood vessel is damaged. This process involves several different proteins and chemical reactions that ultimately lead to the formation of a clot.
The coagulation cascade is initiated when blood comes into contact with tissue factor, which is exposed after damage to the blood vessel wall. This triggers a series of enzymatic reactions that activate clotting factors, leading to the formation of a fibrin clot. Fibrin is a protein that forms a mesh-like structure that traps platelets and red blood cells to form a stable clot.
Once the bleeding has stopped, the coagulation process is regulated and inhibited to prevent excessive clotting. The fibrinolytic system degrades the clot over time, allowing for the restoration of normal blood flow.
Abnormalities in the blood coagulation process can lead to bleeding disorders or thrombotic disorders such as deep vein thrombosis and pulmonary embolism.
Blood plasma substitute
Efaproxiral
Gulf Coast Regional Blood Center
Cohn process
Maurice Stacey
Technological convergence
Allene Jeanes
Fluid replacement
The Pink Spiders
John Douglas Swales
Nash Candelaria
MEAI
Roughnecks: Starship Troopers Chronicles
Jehovah's Witnesses and blood transfusions
Ibogaine
Blood product
Andre Francis Palmer
Elaidic acid
List of unsaturated fatty acids
Cholesteryl ester transfer protein
Blood substitute
Sciadonic acid
Fluoromethane
National Ignition Facility
Ceramide phosphoethanolamine synthase
Malaria culture
Discovery and development of NS5A inhibitors
Polyvinylpyrrolidone
Conjoint analysis
Hemodynamics
Methylone
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Derivatives1
- Cytokinin groups a collection of N 6 -substituted adenine derivatives, including trans -zeatin ( t Z) and isopentenyladenine (iP). (nature.com)
Infusion of plasma1
- There is no proven clinical benefit of infusion of plasma from young donors to cure, mitigate, treat, or prevent these conditions, and there are risks associated with the use of any plasma product," FDA Commissioner Dr. Scott Gottlieb wrote in a statement Tuesday. (kjrh.com)
Albumin6
- A derived protein from skim milk, can be used like the fish protein as a powdered egg (see albumin) substitute. (kosherquest.org)
- Kefalides NA, Arana JA, Bazan A, Velarde N, Rosenthal SM: Evaluation of antibiotic prophylaxis and gammaglobulin, plasma albumin and saline solution therapy in severe burns. (springer.com)
- 15 The basic indication for the use of ALBURX ® 5, Albumin (Human) 5% solution is therefore a plasma or blood volume deficit. (nih.gov)
- The effective colloid osmotic pressure of the serum proteins depends very largely on the relatively small and numerous albumin molecules, which therefore play a decisive role in the maintenance of the circulating plasma volume. (nih.gov)
- Since, however, the life-threatening event in major hemorrhage is the loss of blood volume and not the erythrocyte deficit, the blood volume can, as an emergency measure, be supported by ALBURX ® 5, Albumin (Human) 5% solution or another rapidly acting plasma substitute if blood is not immediately available. (nih.gov)
- Therapy during the first 24 hours is directed at the administration of large volumes of crystalloid solutions and lesser amounts of ALBURX ® 5, Albumin (Human) 5% solution to maintain an adequate plasma volume and protein (colloid) content. (nih.gov)
Protein2
- Promit is a brand name medication included in a group of medications called Blood substitutes and plasma protein fractions . (rxwiki.com)
- 1984), which suggests that consuming relatively high amounts of dietary cholesterol with high amounts of vegetable protein and adequate amounts of dietary fiber will not result in elevated plasma cholesterol concentrations. (scialert.net)
Transfusion1
- Transfusion of either whole blood (cells plus the liquid plasma) or of packed red blood cells (cells only after the liquid is removed) may prove life saving. (petplace.com)
Bone6
- Osseointegrated implants are the best alternative for the restoration of partially or totally edentulous jaws, but in many cases there is not enough bone to place implants, that is why bone substitutes are required to regenerate this tissue. (mynewsdesk.com)
- This article presents a case report, where bone regeneration is performed in an area of bone loss caused by a mandibular implant blade, using biphasic calcium sulfate, platelet-rich plasma and immediate implant placement. (mynewsdesk.com)
- Calcium sulfate is an important material used to achieve bone regeneration, its excellent biocompatibility allows it to be an optimal biomaterial for this purpose, it can be applied alone or combined with other bone substitutes. (mynewsdesk.com)
- This study is conducted to determine the effect of different kinds of bone substitutes and collagen on the concentration of platelet-derived growth factor (PDGF) and transforming growth factor beta-1 (TGF beta-1) in platelet-rich plasma (PRP). (perfusion.com)
- The large share of this segment is attributed to the usage of platelet rich plasma therapy by hospitals and clinics for pain management, regenerative medicines, joints & bone surgeries, cosmetic enhancements, hair growth, and sports injuries. (giiresearch.com)
- Antibodies can be produced by bone marrow plasma cells, which in some cases will keep producing antibodies for decades. (sciforums.com)
Nicardipine plasma levels2
Compounds2
- Hemoglobin adducts of N-substituted aryl compounds in exposure control and risk assessment. (nih.gov)
- The invention generally relates to the field of neurokinin antagonists, and more particularly to new substituted aminopyrimidine compounds which are neurokinin antagonists and use of these compounds and their use in treatment and prevention of neurokinin conditions. (justia.com)
Membrane2
- Subcellular localization of the receptors proposed the endoplasmic reticulum (ER) membrane as a principal cytokinin perception site, while study of cytokinin transport pointed to the plasma membrane (PM)-mediated cytokinin signalling. (nature.com)
- Insertion of helix-forming segments into the membrane and their association determines the structure, function, and expression levels of all plasma membrane proteins. (elifesciences.org)
Concentration5
- Heparin is the recommended anticoagulant for many determinations using whole blood or plasma specimens because of its minimal chelating properties, minimal effects on water shifts, and relatively low cation concentration. (medscape.com)
- In their review, which was published in the Journal of Dietary Supplements , they found that omega-3 fatty acids can significantly improve sperm motility and concentration of docosahexaenoic acid (DHA) in seminal plasma in infertile men. (naturalnews.com)
- In the systematic review and meta-analysis, the researchers looked at the effect of DHA and eicosapentaenoic acid (EPA) supplementation on sperm parameters, such as total sperm concentration, sperm motility, sperm DHA, and seminal plasma DHA concentration in infertile men. (naturalnews.com)
- There was no association between maximal weight loss and plasma sodium concentration (p=0.807). (bmj.com)
- The 5% concentration is approximately isotonic and isooncotic with normal human plasma. (nih.gov)
Platelet transfusions1
- One previous study with similar findings did not include children and did not evaluate trends in plasma or platelet transfusions. (medscape.com)
Transfusions2
- Red blood cell (RBC) and plasma transfusions are decreasing in US hospitals after steadily increasing for more than 2 decades, according to a large, population-based analysis. (medscape.com)
- she received fresh frozen plasma transfusions, but succumbed within few hours. (scirp.org)
Serum15
- Although plasma is preferable to serum as a clinical specimen, there has been little data published to the widespread use of plasma with gel separator. (medscape.com)
- The aim of this study was to investigate the feasibility of lithium-heparin plasma with gel separator as the substitute of serum in clinical biochemical tests. (medscape.com)
- Three specimen types were labeled as serum with gel separator (S), lithium heparin-plasma (P), and lithium heparin-plasma with gel separator (G). Primarily 120 specimens were centrifuged and analyzed within 2 hours (T 0 ), 24 hours (T 24 ), and 48 hours (T 48 ). (medscape.com)
- Wright's staining of serum and plasma smears was used to investigate the formed elements in the upper liquid. (medscape.com)
- The lithium-heparin plasma with gel separator has advantages over serum with gel separator and plasma in clinical biochemical tests. (medscape.com)
- In 2002 the World Health Organization recommended that plasma was more applicable than serum in most clinical tests since plasma, with less interference, was better at reflecting the pathological situation of a patient. (medscape.com)
- [ 1-5 ] There are existing trends that plasma will replace serum in clinical biochemical tests, although there are reports of discrepancy between the testing results between serum and plasma. (medscape.com)
- Gennaro and colleagues [ 10 ] reported that the difference of the matrix effect between serum and plasma was too minimal to be neglected using the high performance liquid chromatography (HPLC) method for the measurement of anti-tuberculosis drugs. (medscape.com)
- Other researchers [ 11-13 ] investigated analytes in plasma and serum immediately separated from cells and concluded that serum and lithium-heparin plasma samples could be used interchangeably. (medscape.com)
- Plasma has some advantages to serum as a clinical specimen. (medscape.com)
- The coagulation process changes the concentrations of numerous constituents of the extra-cellular fluid beyond their maximum allowable limit, [ 16 ] while plasma can better reflect the pathological situation of a patient than serum. (medscape.com)
- Fourth, the serum yield from a given volume of whole blood is always less than plasma, however, certain analyses cannot be performed on plasma. (medscape.com)
- All procedures have a minimum sample requirement, along with any alternate acceptable samples (i.e., substituting plasma for serum). (crlcorp.com)
- Serum, plasma and urine can be used for this assay. (crlcorp.com)
- Serum is the same as blood plasma except that clotting factors (such as fibrin) have been removed. (health-pictures.com)
Growth factors1
- The platelet - rich plasma is a rich source of growth factors with angiogenic and mitogenic properties that accelerates healing of soft and hard tissues. (mynewsdesk.com)
Concentrations4
- Maximum plasma concentrations occur within 3-4 hours after oral administration. (medscape.com)
- Dietary cholesterol affects concentrations of Total Plasma Cholesterol (TC) and Low Density Lipoprotein cholesterol (LDL-c) in humans and animals. (scialert.net)
- 2009). Vegetarians are known to have low plasma total and LDL-c concentrations, which are related to low intake of dietary cholesterol and fat and to high dietary fiber content (Nestel et al . (scialert.net)
- Further, studies have reported that lacto-ovo-vegetarians have low plasma cholesterol concentrations and desirable lipoprotein profiles (Masarei et al . (scialert.net)
Antibodies2
- Effector B cells can begin secreting antibody while they are still small lymphocytes, but the end stage of their maturation pathway is a large plasma cell … which continuously secretes antibodies at the astonishing rate of about 2000 molecules per second. (sciforums.com)
- Plasma cells are activated lymphocytes in full maturity suddenly and severely producing antibodies, usually in response to an infection or at least in response to some kind of inflammatory process. (vin.com)
Biomarkers2
- García-Bailo B, Da Costa LA, Arora P, Karmali M, El-Sohemy A, Badawi A. Plasma Vitamin D and Biomarkers of Cardiometabolic Disease Risk in Adult Canadians, 2007-2009. (cdc.gov)
- In research, " biomarkers " are often used as substitute for an actual outcome, but their presence does not always equate to the clinical presence of disease. (kjrh.com)
Therapy8
- The global platelet rich plasma (PRP) therapy market is expected to grow at a CAGR of 12.2% during the forecast period to reach $882.5 million by 2028. (giiresearch.com)
- In addition, increasing PRP treatments and advancing healthcare in emerging economies are expected to offer significant growth opportunities for platelet rich plasma therapy providers. (giiresearch.com)
- However, the availability of alternatives for PRP treatment and side-effects associated with PRP is expected to restrain the growth of the platelet rich plasma therapy market to some extent during the forecast period. (giiresearch.com)
- Based on type, the global platelet rich plasma therapy market is segmented into pure PRP, leukocyte-rich PRP, pure platelet-rich fibrin, and leukocyte & platelet rich fibrin. (giiresearch.com)
- In 2021, the pure PRP segment is estimated to account for the largest share of the global platelet rich plasma therapy market. (giiresearch.com)
- Based on end user, the global platelet rich plasma therapy market is segmented into hospitals & clinics and research institutes. (giiresearch.com)
- An in-depth analysis of the geographical scenario of the platelet-rich plasma therapy market provides detailed qualitative and quantitative insights about the five major geographies (North America, Europe, Asia-Pacific, Latin America, and the Middle East & Africa) along with the coverage of major countries in each region. (giiresearch.com)
- North America is expected to command the largest share of the global platelet-rich plasma therapy market in 2021, followed by Europe and Asia-Pacific. (giiresearch.com)
Heparin1
- Anticoagulants such as EDTA, citrate, fluoride/oxalate and heparin can be used for collection of plasma samples. (crlcorp.com)
Determinants1
- 2012. "Determinants of Plasma 25-Hydroxyvitamin D and Development of Prediction Models in Three US Cohorts. (harvard.edu)
Laboratory1
- Researchers at the Los Alamos National Laboratory in New Mexico are performing a "futuristic experiment" using dozens of plasma guns to harness fusion energy. (naturalnews.com)
Donors5
- Wannabe vampires, beware: The US Food and Drug Administration warned Tuesday against using plasma infusions from young blood donors to ward off the effects of normal aging as well as other more serious conditions. (kjrh.com)
- Gottlieb said that "a growing number of clinics" are offering plasma from young donors and similar therapies, though he did not name any in particular. (kjrh.com)
- Young plasma treatments are intravenous infusions of plasma from young donors, who are in the age range of 16 to 25," Ambrosia's website said. (kjrh.com)
- Gottlieb wrote, "Simply put, we're concerned that some patients are being preyed upon by unscrupulous actors touting treatments of plasma from young donors as cures and remedies. (kjrh.com)
- This product is prepared from the plasma of US donors. (nih.gov)
Milk1
- The general public can purchase an egg substitute made from egg whites, vegetable oil, nonfat dry milk, emulsifiers, and artificial flavors and colors. (kosherquest.org)
Proteins2
Obtained from blood1
- A third source of egg substitutes is plasma obtained from blood. (kosherquest.org)
PEOPLE1
- A government website lists a clinical trial sponsored by Ambrosia that included 200 people who received young donor plasma treatments. (kjrh.com)
Advantages1
- The use of supersonic rotation of a plasma in mirror geometry has distinct advantages for thermonuclear fusion. (aip.org)
Cell6
- Plasma cell pododermatitis is a foot pad disease of cats that is fairly classical in its appearance yet its significance is poorly understood. (vin.com)
- Plasma cell pododermatitis literally means foot inflammation involving infiltration by plasma cells. (vin.com)
- Some studies have found a link between plasma cell pododermatitis and feline immunodeficiency virus (FIV) infection so it is important to screen an affected cat for this virus. (vin.com)
- Exactly what the link is between these two conditions remains unclear but approximately 50 percent of cats with plasma cell pododermatitis are FIV-positive. (vin.com)
- On blood tests, cats with plasma cell pododermatitis usually have elevated numbers of circulating lymphocytes and high circulating antibody (globulin) levels, so such findings are supportive of making this diagnosis. (vin.com)
- While doxycycline is an antibiotic, it also has immunomodulating properties and we believe it is these properties that are effective in treating plasma cell pododermatitis. (vin.com)
Receiving treatments1
- There is a continuous need for blood, platelets, plasma, cryoprecipitate and granulocytes to support Clinical Center patients receiving treatments at the hospital. (nih.gov)
Basic1
- and perform basic and applied research on blood substitutes. (nih.gov)
Components1
- The plasma guns are components of the lab's Plasma Liner Experiment (PLX), a fusion reactor operating on a novel combination of two existing methods of hydrogen fusion. (naturalnews.com)
Products2
- If a certified version of these products can be found, the kosher consumer will find them excellent for making scrambled eggs and as substitutes for fresh eggs in recipes. (kosherquest.org)
- These two egg substitutes can theoretically be produced under kosher supervision, although the halacha opposes the introduction of dairy products into breads. (kosherquest.org)
Oral1
- Oral or intravenous nicardipine may increase cyclosporine and tacrolimus plasma levels. (nih.gov)
Cells2
- Blood plasma is the liquid component of blood, in which the blood cells are suspended. (health-pictures.com)
- Less invasively, a needle aspirate can be used to harvest some cells from the affected foot and check for an abundance of plasma cells. (vin.com)
Human1
- There is no substitute for human blood and it cannot be manufactured. (nih.gov)
Treatment3
- All information on this site is provided "as-is" for informational purposes only and is not a substitute for medical advice or treatment. (rxwiki.com)
- Balzers, Liechtenstein, December 18, 2012 - Oerlikon Balzers has launched its next generation of Pulsed-Plasma Diffusion (PPDTM) technology for the surface treatment of large forming tools. (oerlikon.com)
- It was founded by Jesse Karmazin , a graduate of Princeton University and the Stanford School of Medicine, and the company's website refers to plasma as a "medical treatment. (kjrh.com)
Fluid1
- Dobke MK, Hayes EC, Baxter CR: Leukotrienes LTB 4 in thermally injured patients' plasma and burn blister fluid. (springer.com)
Rate1
- It charges $8,000 for a liter of young plasma and offers 2 liters at a rate of $12,000. (kjrh.com)
Volume2
- A blood plasma substitute may refer to: An artificially made substance designed to have one or more of the vast amount of functions of the contents of the blood plasma Volume expander (although providing volume is only one of many functions of blood plasma) This disambiguation page lists articles associated with the title Blood plasma substitute. (wikipedia.org)
- Hilton JG: Effects of alterations of polyunsaturated fatty acid metabolism upon plasma volume loss induced by thermal injury. (springer.com)
Levels1
- Nicardipine may increase cyclosporine and tacrolimus plasma levels. (nih.gov)
Rich plasma2
- Now a days there are different kinds of regeneration materials such as: calcium sulfate (biomaterial that has been used for many years), and the platelet-rich plasma (used to potentiate the healing). (mynewsdesk.com)
- After the insertion of the implants, implant in 46 had a large space around it (Figure 5) so a graft of BONDBONE® mixed with platelet-rich plasma was inserted (Figure 6). (mynewsdesk.com)
Result1
- Young plasma is the result of research into the science of blood," the website reads. (kjrh.com)