An acquired disease of unknown etiology, chronic course, and tendency to recur. It is characterized by inflammation and degeneration of cartilage and can result in deformities such as floppy ear and saddle nose. Loss of cartilage in the respiratory tract can lead to respiratory obstruction.
Cartilage of the EAR AURICLE and the EXTERNAL EAR CANAL.
Distortion or disfigurement of the ear caused by disease or injury after birth.
A congenital or acquired condition of underdeveloped or degeneration of CARTILAGE in the TRACHEA and the BRONCHI. This results in a floppy non-rigid airway making patency difficult to maintain.
Condition characterized by large, rapidly extending, erythematous, tender plaques on the upper body usually accompanied by fever and dermal infiltration of neutrophilic leukocytes. It occurs mostly in middle-aged women, is often preceded by an upper respiratory infection, and clinically resembles ERYTHEMA MULTIFORME. Sweet syndrome is associated with LEUKEMIA.
PROTEOGLYCANS-associated proteins that are major components of EXTRACELLULAR MATRIX of various tissues including CARTILAGE; and INTERVERTEBRAL DISC structures. They bind COLLAGEN fibers and contain protein domains that enable oligomer formation and interaction with other extracellular matrix proteins such as CARTILAGE OLIGOMERIC MATRIX PROTEIN.
The essential part of the hearing organ consists of two labyrinthine compartments: the bony labyrinthine and the membranous labyrinth. The bony labyrinth is a complex of three interconnecting cavities or spaces (COCHLEA; VESTIBULAR LABYRINTH; and SEMICIRCULAR CANALS) in the TEMPORAL BONE. Within the bony labyrinth lies the membranous labyrinth which is a complex of sacs and tubules (COCHLEAR DUCT; SACCULE AND UTRICLE; and SEMICIRCULAR DUCTS) forming a continuous space enclosed by EPITHELIUM and connective tissue. These spaces are filled with LABYRINTHINE FLUIDS of various compositions.
The body's defense mechanism against foreign organisms or substances and deviant native cells. It includes the humoral immune response and the cell-mediated response and consists of a complex of interrelated cellular, molecular, and genetic components.
A genus of the family CORONAVIRIDAE which causes respiratory or gastrointestinal disease in a variety of vertebrates.
Virus diseases caused by the CORONAVIRUS genus. Some specifics include transmissible enteritis of turkeys (ENTERITIS, TRANSMISSIBLE, OF TURKEYS); FELINE INFECTIOUS PERITONITIS; and transmissible gastroenteritis of swine (GASTROENTERITIS, TRANSMISSIBLE, OF SWINE).
Nonsusceptibility to the invasive or pathogenic effects of foreign microorganisms or to the toxic effect of antigenic substances.
The capacity of a normal organism to remain unaffected by microorganisms and their toxins. It results from the presence of naturally occurring ANTI-INFECTIVE AGENTS, constitutional factors such as BODY TEMPERATURE and immediate acting immune cells such as NATURAL KILLER CELLS.
A species in the genus CORONAVIRUS causing the common cold and possibly nervous system infections in humans. It lacks hemagglutinin-esterase.
A species of CORONAVIRUS infecting neonatal calves, presenting as acute diarrhea, and frequently leading to death.

A new animal model for relapsing polychondritis, induced by cartilage matrix protein (matrilin-1). (1/60)

Relapsing polychondritis (RP) differs from rheumatoid arthritis (RA) in that primarily cartilage outside diarthrodial joints is affected. The disease usually involves trachea, nose, and outer ears. To investigate whether the tissue distribution of RP may be explained by a specific immune response, we immunized rats with cartilage matrix protein (matrilin-1), a protein predominantly expressed in tracheal cartilage. After 2-3 weeks, some rats developed a severe inspiratory stridor. They had swollen noses and/or epistaxis, but showed neither joint nor outer ear affection. The inflammatory lesions involved chronic active erosions of cartilage. Female rats were more susceptible than males. The disease susceptibility was controlled by both MHC genes (f, l, d, and a haplotypes are high responders, and u, n, and c are resistant) and non-MHC genes (the LEW strain is susceptible; the DA strain is resistant). However, all strains mounted a pronounced IgG response to cartilage matrix protein. The initiation and effector phase of the laryngotracheal involvement causing the clinical symptoms were shown to depend on alphabeta T cells. Taken together, these results represent a novel model for RP: matrilin-1-induced RP. Our findings also suggest that different cartilage proteins are involved in pathogenic models of RP and RA.  (+info)

Autoreactivity against matrilin-1 in a patient with relapsing polychondritis. (2/60)

Relapsing polychondritis (RP) is a rare inflammatory disease of cartilage. Chondritis of the auricular, nasal, and tracheal cartilages predominates in this disease, suggesting a response to a tissue-specific antigen. One potential antigen is matrilin-1, a cartilage matrix protein found uniquely in the tracheal, auricular, and nasal cartilage of adults. We describe herein a patient with RP who had both a humoral and a cellular immune response directed toward the cartilage matrix protein matrilin-1.  (+info)

Tracheobronchial involvement in relapsing polychondritis. (3/60)

Relapsing polychondritis (RPC) is a multisystem disorder of chondromalacia involving any cartilage. Respiratory tract involvement is the greatest threat to life. We report a patient with stenosis of the subglottic trachea and left main bronchus who suddenly ceased breathing. As this patient did not have any other clinical features of RPC, the diagnosis was difficult. CT showed circumferential worm-eaten-like thickening suggesting a deformity and edema of the tracheal mucosa. Biopsy of the tracheal and thyroid cartilage revealed mild cartilage degeneration and infiltration with inflammatory cells. Therefore, the patient was diagnosed as having RPC. She is currently well 24 months after Montgomery T tube intubation with systemic steroids. Narrowing of the left main bronchus has not worsened.  (+info)

Autologous stem-cell transplantation in refractory autoimmune diseases after in vivo immunoablation and ex vivo depletion of mononuclear cells. (4/60)

Autoimmune diseases that are resistant to conventional treatment cause severe morbidity and even mortality. In the present study we demonstrate that complete remissions can be achieved in refractory polychondritis and systemic lupus erythematosus (SLE), even at advanced stage, with the use of autologous stem-cell transplantation (SCT). Remissions persisted after reconstitution of the immune system. In the treatment of advanced systemic sclerosis (SSc), stable disease may be achieved with autologous SCT.  (+info)

Orbital mucosa-associated lymphoid tissue (MALT)-type lymphoma in a patient with relapsing polychondritis. (5/60)

Relapsing polychondritis is characterized by recurrent inflammation of the cartilaginous tissues of the ears, nose, peripheral joints, and the tracheobronchial tree. The eye is also a frequent target organ in relapsing polychondritis, and proptosis is a well-recognized manifestation of eye involvement. Similar to other rheumatologic diseases, an association of relapsing polychondritis with malignancy has been reported. We describe a patient with relapsing polychondritis who presented with exophthalmos. When treatment directed toward control of her underlying disease was only partially effective, further investigation revealed that she had an orbital mucosa-associated lymphoid tissue (MALT)-type B cell lymphoma. We hypothesize that the lymphoma resulted from malignant transformation of the relapsing polychondritis-induced inflammatory pseudotumor and emphasize that neoplastic disease should be considered in the differential diagnosis in patients with relapsing polychondritis presenting with exophthalmos.  (+info)

Active aortitis in relapsing polychondritis. (6/60)

Relapsing polychondritis (RP) is a rare inflammatory multiorgan disorder affecting cartilaginous structures and other connective tissues. Serious cardiovascular complications have been reported in patients with RP, the most frequent being aortic or mitral regurgitation and aortic aneurysms. Aortitis is a very rare complication. An unusual case of active aortitis in a patient with RP, despite intensive immunosuppressive treatment, is described with a special emphasis on the pathological findings.  (+info)

Pulmonary fibrosis with intractable pneumothorax: new pulmonary manifestation of relapsing polychondritis. (7/60)

Relapsing Polychondritis is a rare disease which causes the repetitive inflammation of cartilage and connective tissues. Although the large airway is sometimes involved and the stenosis of them often influences the prognosis of the patients, there have been few reports concerning the manifestation of the peripheral lung. A 60-year-old man with pulmonary fibrosis was admitted to a regional hospital due to sudden deafness, and then he suffered from relapsing polychondritis. During the steroid therapy, he also suffered from bilateral pneumothoraces. His computed tomogram revealed many bilateral bullae, emphysematous changes, and fibrotic changes in bilateral lungs. The mechanism of generating peripheral pulmonary manifestations is also discussed.  (+info)

Identification of type II collagen peptide 261-273-specific T cell clones in a patient with relapsing polychondritis. (8/60)

OBJECTIVE: To characterize and clone T cells specific for type II collagen (CII) in a patient with relapsing polychondritis (RP) and to establish whether the immunodominant epitope of CII determined in HLA transgenic mice is used in the human autoimmune response to CII. METHODS: T cell responses to CII were examined in a patient with RP, who was heterozygous for the HLA-DR allele DRB1*0101/DRB1*0401. T cell clones were established from this patient and characterized for peptide specificity, class II restriction, cytokine production, and staining with HLA-DRB1*0401 class II tetramers. RESULTS: A response to CII and the peptide 255-273 was present in this patient. T cells specific for the CII epitope 261-273 were cloned. Evaluation of these clones demonstrated a response to CII 261-273 in the context of both DR alleles. HLA-DR4 CII tetramer did not demonstrate staining of either CII-specific DRB1*0401-restricted T cell clones or a polyclonal population of CII-reactive T cells from this individual. CONCLUSION: T cells directed against CII were present in this patient with RP. Also, T cell clones isolated from this individual were found to be specific for the CII peptide 261-273 and were restricted to either the DRB1*0101 or the DRB1*0401 allele. These findings establish that a T cell response directed against CII is present in this patient with RP and that the CII peptide 261-273 plays a role in the human immune response to CII.  (+info)

Relapsing polychondritis is a rare autoimmune disease characterized by inflammation and damage to the cartilaginous structures in the body. The condition can affect multiple organs and tissues, including the ears, nose, trachea, bronchi, joints, and cardiovascular system. It is called "relapsing" because it tends to involve recurring episodes of inflammation and damage, followed by periods of remission.

The hallmark symptom of relapsing polychondritis is pain and swelling in the ears, nose, or airways. Other symptoms may include:

* Redness, tenderness, and warmth in affected areas
* Hearing loss or tinnitus (ringing in the ears)
* Nasal congestion, runny nose, or nosebleeds
* Hoarseness or difficulty speaking
* Wheezing, shortness of breath, or coughing
* Joint pain, stiffness, or swelling
* Skin rashes or sores
* Eye inflammation or dryness
* Heart murmurs or other cardiovascular symptoms

The exact cause of relapsing polychondritis is not known, but it is thought to involve an abnormal immune response in which the body's own antibodies attack and damage cartilage and other tissues. The diagnosis of relapsing polychondritis is typically based on a combination of clinical symptoms, laboratory tests, and imaging studies.

There is no cure for relapsing polychondritis, but treatment can help manage the symptoms and prevent complications. Treatment may include corticosteroids, immunosuppressive drugs, and other medications to reduce inflammation and suppress the immune system. In severe cases, surgery may be necessary to repair or replace damaged tissues.

Ear cartilage, also known as auricular cartilage, refers to the flexible connective tissue that makes up the structural framework of the external ear or pinna. The ear cartilage provides support and shape to the ear, helping to direct sound waves into the ear canal and towards the eardrum.

The ear cartilage is composed of type II collagen fibers and proteoglycans, which give it its flexibility and resiliency. It is covered by a thin layer of skin on both sides and contains no bones. Instead, the ear cartilage is shaped and maintained by the surrounding muscles and connective tissue.

There are three main parts of the ear cartilage: the helix, the antihelix, and the tragus. The helix is the outer rim of the ear, while the antihelix is the curved ridge that runs parallel to the helix. The tragus is the small piece of cartilage that projects from the front of the ear canal.

Ear cartilage can be affected by various conditions, including trauma, infection, and degenerative changes associated with aging. In some cases, surgical procedures may be required to reshape or reconstruct damaged ear cartilage.

Acquired ear deformities refer to abnormal shapes or structures of the ear that result from injury, infection, inflammation, or other external factors after birth. These deformities can affect the appearance and function of the ear, causing symptoms such as hearing loss or discomfort. Examples of acquired ear deformities include:

1. Cauliflower ear: a condition characterized by swelling, thickening, and distortion of the ear caused by repeated trauma or injury to the ear cartilage.
2. Microtia: a congenital ear abnormality that can become worse over time due to infection, inflammation, or trauma, resulting in an underdeveloped or absent ear.
3. Macrotia: an abnormally large ear that may result from injury or other external factors.
4. Stenosis: a narrowing of the ear canal that can result from chronic inflammation, infection, or scarring.
5. Hematoma: a collection of blood in the ear tissue caused by trauma or injury, which can lead to deformity if not treated promptly.
6. Keloids: overgrowths of scar tissue that can form after injury or surgery and distort the shape of the ear.

Treatment for acquired ear deformities may include surgical reconstruction, splinting, or other interventions depending on the severity and underlying cause of the condition.

Tracheobronchomalacia is a medical condition that refers to the abnormal softening and weakness of the tracheal and bronchial walls, leading to their collapse or narrowing during breathing, particularly during expiration. This collapse can cause symptoms such as wheezing, shortness of breath, coughing, and recurrent respiratory infections. The condition can be congenital or acquired, with common causes including aging, chronic obstructive pulmonary disease (COPD), and long-term intubation. In severe cases, tracheobronchomalacia may require surgical intervention to stabilize the airway and improve breathing.

Sweet syndrome, also known as acute febrile neutrophilic dermatosis, is a skin condition characterized by the rapid onset of painful, red, and swollen skin lesions. The lesions are often accompanied by fever and elevated white blood cell count, particularly an increase in neutrophils.

The medical definition of Sweet syndrome includes the following criteria:

1. Abrupt onset of painful, erythematous (red), and edematous (swollen) papules, plaques, or nodules.
2. Fever greater than 38°C (100.4°F).
3. Leukocytosis with a predominance of neutrophils in the peripheral blood.
4. Histopathological evidence of a dense dermal infiltrate of neutrophils without evidence of vasculitis.
5. Rapid response to systemic corticosteroids.

Sweet syndrome can be associated with various medical conditions, such as infections, malignancies, and inflammatory diseases, or it can occur without an identifiable underlying cause (idiopathic).

Matrilin proteins are a group of extracellular matrix (ECM) proteins that are predominantly found in cartilaginous tissues, such as articular cartilage, costal cartilage, and intervertebral discs. They belong to the von Willebrand factor A (vWF-A) domain-containing protein family and play important roles in maintaining the structural integrity and organization of the ECM.

Matrilin proteins are composed of multiple domains, including vWF-A domains, coiled-coil domains, and calcium-binding epidermal growth factor (cbEGF)-like domains. They can form multimeric complexes through their coiled-coil domains, which helps to stabilize the ECM network.

There are four known matrilin proteins in humans, designated as Matrilin-1, Matrilin-2, Matrilin-3, and Matrilin-4. Each of these proteins has distinct tissue distribution patterns and functions. For example, Matrilin-1 is primarily found in hyaline cartilage and is involved in regulating chondrocyte differentiation and matrix assembly. Matrilin-2 is widely expressed in various tissues, including cartilage, tendon, and ligament, and plays a role in maintaining the organization of collagen fibrils. Matrilin-3 is specifically expressed in articular cartilage and is involved in regulating the formation and maintenance of the cartilaginous matrix. Matrilin-4 is found in both hyaline and fibrocartilage, as well as in tendons and ligaments, and has been implicated in regulating collagen fibrillogenesis and tissue development.

Mutations in matrilin genes have been associated with various musculoskeletal disorders, such as multiple epiphyseal dysplasia (MED) and spondyloepimetaphyseal dysplasia (SEMD). These genetic defects can lead to abnormalities in the structure and organization of the ECM, resulting in joint pain, stiffness, and reduced mobility.

The inner ear is the innermost part of the ear that contains the sensory organs for hearing and balance. It consists of a complex system of fluid-filled tubes and sacs called the vestibular system, which is responsible for maintaining balance and spatial orientation, and the cochlea, a spiral-shaped organ that converts sound vibrations into electrical signals that are sent to the brain.

The inner ear is located deep within the temporal bone of the skull and is protected by a bony labyrinth. The vestibular system includes the semicircular canals, which detect rotational movements of the head, and the otolith organs (the saccule and utricle), which detect linear acceleration and gravity.

Damage to the inner ear can result in hearing loss, tinnitus (ringing in the ears), vertigo (a spinning sensation), and balance problems.

The immune system is a complex network of cells, tissues, and organs that work together to defend the body against harmful invaders. It recognizes and responds to threats such as bacteria, viruses, parasites, fungi, and damaged or abnormal cells, including cancer cells. The immune system has two main components: the innate immune system, which provides a general defense against all types of threats, and the adaptive immune system, which mounts specific responses to particular threats.

The innate immune system includes physical barriers like the skin and mucous membranes, chemical barriers such as stomach acid and enzymes in tears and saliva, and cellular defenses like phagocytes (white blood cells that engulf and destroy invaders) and natural killer cells (which recognize and destroy virus-infected or cancerous cells).

The adaptive immune system is more specific and takes longer to develop a response but has the advantage of "remembering" previous encounters with specific threats. This allows it to mount a faster and stronger response upon subsequent exposures, providing immunity to certain diseases. The adaptive immune system includes T cells (which help coordinate the immune response) and B cells (which produce antibodies that neutralize or destroy invaders).

Overall, the immune system is essential for maintaining health and preventing disease. Dysfunction of the immune system can lead to a variety of disorders, including autoimmune diseases, immunodeficiencies, and allergies.

A coronavirus is a type of virus that causes respiratory illnesses, such as the common cold, and more severe diseases including Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). These viruses are typically spread through close contact with an infected person when they cough or sneeze. They can also spread by touching a surface or object that has the virus on it and then touching your own mouth, nose, or eyes.

Coronaviruses are named for the crown-like spikes on their surface. They are zoonotic, meaning they can be transmitted between animals and people. Common signs of infection include fever, cough, and shortness of breath. In more severe cases, infection can cause pneumonia, severe acute respiratory syndrome, kidney failure, and even death.

One of the most recently discovered coronaviruses is SARS-CoV-2, which causes the disease COVID-19. This virus was first identified in Wuhan, China in late 2019 and has since spread to become a global pandemic.

Coronaviruses are a large family of viruses that can cause illnesses ranging from the common cold to more severe diseases such as pneumonia. The name "coronavirus" comes from the Latin word "corona," which means crown or halo, reflecting the distinctive appearance of the virus particles under electron microscopy, which have a crown-like structure due to the presence of spike proteins on their surface.

Coronaviruses are zoonotic, meaning they can be transmitted between animals and humans. Some coronaviruses are endemic in certain animal populations and occasionally jump to humans, causing outbreaks of new diseases. This is what happened with Severe Acute Respiratory Syndrome (SARS) in 2002-2003, Middle East Respiratory Syndrome (MERS) in 2012, and the most recent Coronavirus Disease 2019 (COVID-19), caused by SARS-CoV-2.

Coronavirus infections typically cause respiratory symptoms such as cough, shortness of breath, and fever. In severe cases, they can lead to pneumonia, acute respiratory distress syndrome (ARDS), and even death, especially in older adults or people with underlying medical conditions. Other symptoms may include fatigue, muscle aches, headache, sore throat, and gastrointestinal issues such as nausea, vomiting, and diarrhea.

Preventive measures for coronavirus infections include frequent hand washing, wearing face masks, practicing social distancing, avoiding close contact with sick individuals, and covering the mouth and nose when coughing or sneezing. There are currently vaccines available to prevent COVID-19, which have been shown to be highly effective in preventing severe illness, hospitalization, and death from the disease.

Immunity, in medical terms, refers to the body's ability to resist or fight against harmful foreign substances or organisms such as bacteria, viruses, parasites, and fungi. This resistance is achieved through various mechanisms, including the production of antibodies, the activation of immune cells like T-cells and B-cells, and the release of cytokines and other chemical messengers that help coordinate the immune response.

There are two main types of immunity: innate immunity and adaptive immunity. Innate immunity is the body's first line of defense against infection and involves nonspecific mechanisms such as physical barriers (e.g., skin and mucous membranes), chemical barriers (e.g., stomach acid and enzymes), and inflammatory responses. Adaptive immunity, on the other hand, is specific to particular pathogens and involves the activation of T-cells and B-cells, which recognize and remember specific antigens (foreign substances that trigger an immune response). This allows the body to mount a more rapid and effective response to subsequent exposures to the same pathogen.

Immunity can be acquired through natural means, such as when a person recovers from an infection and develops immunity to that particular pathogen, or artificially, through vaccination. Vaccines contain weakened or inactivated forms of a pathogen or its components, which stimulate the immune system to produce a response without causing the disease. This response provides protection against future infections with that same pathogen.

Innate immunity, also known as non-specific immunity or natural immunity, is the inherent defense mechanism that provides immediate protection against potentially harmful pathogens (like bacteria, viruses, fungi, and parasites) without the need for prior exposure. This type of immunity is present from birth and does not adapt to specific threats over time.

Innate immune responses involve various mechanisms such as:

1. Physical barriers: Skin and mucous membranes prevent pathogens from entering the body.
2. Chemical barriers: Enzymes, stomach acid, and lysozyme in tears, saliva, and sweat help to destroy or inhibit the growth of microorganisms.
3. Cellular responses: Phagocytic cells (neutrophils, monocytes, macrophages) recognize and engulf foreign particles and pathogens, while natural killer (NK) cells target and eliminate virus-infected or cancerous cells.
4. Inflammatory response: When an infection occurs, the innate immune system triggers inflammation to increase blood flow, recruit immune cells, and remove damaged tissue.
5. Complement system: A group of proteins that work together to recognize and destroy pathogens directly or enhance phagocytosis by coating them with complement components (opsonization).

Innate immunity plays a crucial role in initiating the adaptive immune response, which is specific to particular pathogens and provides long-term protection through memory cells. Both innate and adaptive immunity work together to maintain overall immune homeostasis and protect the body from infections and diseases.

Human coronavirus 229E (HCoV-229E) is a species of coronavirus that causes respiratory infections in humans. It is one of the several coronaviruses known to cause the common cold. HCoV-229E was first identified in the 1960s and is named after the number assigned to it in the laboratory where it was discovered.

HCoV-229E infects the human body through the respiratory tract, and it primarily affects the upper respiratory system, causing symptoms such as runny nose, sore throat, cough, and fever. In some cases, HCoV-229E can also cause lower respiratory infections, such as pneumonia, especially in individuals with weakened immune systems or underlying medical conditions.

HCoV-229E is an enveloped, positive-sense, single-stranded RNA virus that belongs to the family Coronaviridae and the genus Alphacoronavirus. It is transmitted through respiratory droplets produced when an infected person coughs, sneezes, or talks. The virus can also survive on surfaces for several hours, making it possible to contract the infection by touching contaminated objects.

There is no specific treatment for HCoV-229E infections, and most people recover within a week or two with rest and symptomatic relief. However, severe cases may require hospitalization and supportive care, such as oxygen therapy and mechanical ventilation. Preventive measures, such as hand hygiene, wearing masks, and avoiding close contact with infected individuals, can help reduce the transmission of HCoV-229E and other respiratory viruses.

Bovine coronavirus (BCoV) is a species of coronavirus that infects cattle and other animals such as yaks, deer, and occasionally humans. It is an enveloped, single-stranded, positive-sense RNA virus belonging to the genus Betacoronavirus in the family Coronaviridae.

BCoV primarily causes respiratory and enteric diseases in cattle, resulting in symptoms such as pneumonia, coughing, diarrhea, and decreased appetite. The virus is transmitted through direct contact with infected animals or their feces, contaminated food, water, or fomites.

In humans, BCoV infection is rare but has been associated with respiratory illnesses in people working closely with cattle, such as farmers, abattoir workers, and veterinarians. The symptoms of human BCoV infection are similar to those caused by other coronaviruses, including fever, cough, and shortness of breath.

Prevention measures for BCoV include good hygiene practices, wearing personal protective equipment when working with cattle, and vaccination of animals against the virus. There is currently no specific treatment or vaccine available for human BCoV infection.

Chapter 28, relapsing polychondritis. Rapini RP, Warner NB (2006). "Relapsing polychondritis". Clin. Dermatol. 24 (6): 482-5. ... "Relapsing Polychondritis: Autoimmune Disorders of Connective Tissue". Merck Manual Home Health Handbook. "Relapsing ... The following table shows the history of the nomenclature of relapsing polychondritis. The current name, Relapsing ... Relapsing polychondritis occurs as often in men as in women. In a Mayo Clinic series, the annual incidence was about 3.5 cases ...
Rapini (2006). "Relapsing polychondritis". Clin. Dermatol. 24 (6): 482-5. doi:10.1016/j.clindermatol.2006.07.018. PMID 17113965 ... present in the setting of nontraumatic inflammatory injury of auricular connective tissue such as in relapsing polychondritis ( ...
Puéchal X, Terrier B, Mouthon L, Costedoat-Chalumeau N, Guillevin L, Le Jeunne C (March 2014). "Relapsing polychondritis". ... Immunological diseases, e.g., relapsing polychondritis, autoimmune hepatitis, granulomatosis with polyangiitis, Horton disease ... "Lyme disease and relapsing fever in Mexico: An overview of human and wildlife infections". PLOS ONE. 15 (9): e0238496. Bibcode: ...
Relapsing polychondritis. There are no clinical trials but there are many case reports that dapsone is effective at doses of 25 ... Rapini RP, Warner NB (2006). "Relapsing polychondritis". Clin. Dermatol. 24 (6): 482-5. doi:10.1016/j.clindermatol.2006.07.018 ... mg/day to 200 mg/day for treatment of relapsing polychondritis. Dermatitis herpetiformis in combination with a gluten-free diet ...
It appears to have limited effect in relapsing polychondritis, as it may only be useful for the treatment of chondritis and ... Puéchal X, Terrier B, Mouthon L, Costedoat-Chalumeau N, Guillevin L, Le Jeunne C (March 2014). "Relapsing polychondritis". ...
... is the most frequently used biological agent in treating relapsing polychondritis. Half of the patients saw benefit ... Puéchal X, Terrier B, Mouthon L, Costedoat-Chalumeau N, Guillevin L, Le Jeunne C (March 2014). "Relapsing polychondritis". ... Kemta Lekpa F, Kraus VB, Chevalier X (April 2012). "Biologics in relapsing polychondritis: a literature review". Seminars in ...
Puéchal X, Terrier B, Mouthon L, Costedoat-Chalumeau N, Guillevin L, Le Jeunne C (March 2014). "Relapsing polychondritis". ... Conjunctivitis is associated with the autoimmune disease relapsing polychondritis. Cultures are not often taken or needed as ... 2014). "Diagnosis and classification of relapsing polychondritis". Journal of Autoimmunity. 48-49: 53-9. doi:10.1016/j.jaut. ...
Puéchal X, Terrier B, Mouthon L, Costedoat-Chalumeau N, Guillevin L, Le Jeunne C (March 2014). "Relapsing polychondritis". ... In rare cases, it may be a symptom of collagen vascular diseases, including relapsing polychondritis, rheumatoid arthritis, ... February-March 2014). "Diagnosis and classification of relapsing polychondritis". Journal of Autoimmunity. 48-49: 53-59. doi: ...
"Relapsing polychondritis". Joint, Bone, Spine: Revue du Rhumatisme. Elsevier. 81 (2): 118-124. doi:10.1016/j.jbspin.2014.01.001 ... lupus erythematosus Sjögren syndrome Scleroderma Polymyositis Dermatomyositis Behçet's disease Relapsing polychondritis ...
Relapsing Polychondritis Foundation (31 March 2022). "The Relapsing Polychondritis Foundation Invests in the Next Phase of ... Relapsing Polychondritis. Relapsing Polychondritis Foundation. Retrieved 19 July 2022.{{cite web}}: CS1 maint: date and year ( ... Bammert, David (22 June 2022). "The Relapsing Polychondritis Foundation Invests in Potentially Groundbreaking Collaborative ... relapsing polychondritis, and polyarteritis nodosa. Inflammation may also affect the lungs. Hematologic issues include ...
"The Relapsing Polychondritis Foundation Invests in the Next Phase of VEXAS Research". The Relapsing Polychondritis Foundation. ... polychondritis.org. Relapsing Polychondritis Foundation. Retrieved 19 July 2022. Reinberg, Danny (5 May 2014). "Past Students ... Bammert, David (21 June 2022). "The Relapsing Polychondritis Foundation Invests in Potentially Groundbreaking Collaborative ...
Chondritis Osteochondritis Relapsing polychondritis Gulihar, Abhinav; Robati, Shibby; Twaij, Haider; Salih, Alan; Taylor, ...
Relapsing polychondritis: a systemic inflammatory condition involving cartilage in many parts of the body, but often including ... Relapsing polychondritis is an autoimmune disease treated with immunomodulating medications (medications that help modulate the ... "Relapsing Polychondritis Clinical Presentation: History, Physical, Causes". emedicine.medscape.com. Retrieved 2018-03-14. ...
Kim CM, Kim BS, Cho KJ, Hong SJ (April 2003). "Laryngotracheal involvement of relapsing polychondritis in a Korean girl". ... "Laryngotracheal involvement as the initial manifestation of relapsing polychondritis". J Chin Med Assoc. 68 (6): 279-82. doi: ...
It takes several forms, osteochondritis, costochondritis, and relapsing polychondritis among them. Costochondritis is notable ... commonly involving the outer ear Relapsing polychondritis "Chondritis" at Dorland's Medical Dictionary v t e (All articles with ...
Both relapsing polychondritis and pseudoxanthoma elasticum may cause abdominal aortic aneurysm. Atherosclerosis: The AAA was ...
59 percent of patients with relapsing polychondritis have either episcleritis or scleritis. Rarely, episcleritis may be caused ... relapsing polychondritis, systemic lupus erythematosus), psoriatic arthritis, ankylosing spondylitis, Cogan syndrome, rosacea, ...
The name stands for "mouth and genital ulcers with inflamed cartilage" (relapsing polychondritis). PFAPA syndrome is a rare ...
Cristina had had several autoimmune disorders, including relapsing polychondritis for almost two decades. On April 1, 2020, ... including relapsing polychondritis. Her two albums for ZE were reissued in 2004, after Michael Esteban revived the label. ...
Relapsing polychondritis: a destruction, probably autoimmune, of cartilage, especially of the nose and ears, causing ...
Relapsing polychondritis can also spare the posterior wall, though it is not typically nodular in appearance. Prakash, UB ( ...
Relapsing polychondritis: a destruction, probably autoimmune, of cartilage, especially of the nose and ears, causing ...
Serrault died from relapsing polychondritis at his home in Équemauville on 29 July 2007 at age 79. He was buried in Sainte- ...
... or pathological changes caused by inflammatory diseases like Relapsing polychondritis. In patients with TBM in one study, the ... "Sudden Respiratory Failure due to Tracheobronchomalacia by Relapsing Polychondritis, Successfully Rescued by Multiple Metallic ...
In 1923 he was the first one who discovered the autoimmune disease relapsing polychondritis, that he himself named ...
Usually secondary to systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), relapsing polychondritis, Behçet's disease ...
... relapsing polychondritis, and polyarthritis, can also cause it. Other causes may include aspiration of foreign bodies, burns, ...
"Relapsing Polychondritis: Autoimmune Disorders of Connective Tissue: Merck Manual Home Health Handbook". Girschick HJ, ...
... is a condition associated with nasal trauma, congenital syphilis, relapsing polychondritis, granulomatosis with ...
... is a cutaneous condition with features of both Behçet's disease and relapsing polychondritis. Recently, it has been questioned ...
Chapter 28, relapsing polychondritis. Rapini RP, Warner NB (2006). "Relapsing polychondritis". Clin. Dermatol. 24 (6): 482-5. ... "Relapsing Polychondritis: Autoimmune Disorders of Connective Tissue". Merck Manual Home Health Handbook. "Relapsing ... The following table shows the history of the nomenclature of relapsing polychondritis. The current name, Relapsing ... Relapsing polychondritis occurs as often in men as in women. In a Mayo Clinic series, the annual incidence was about 3.5 cases ...
Treatment for relapsing polychondritis includes NSAIDS, corticosteroids, immunosuppressant medication, and surgery. Learn more ... Can relapsing polychondritis be cured? There is no cure for relapsing polychondritis. Treatment focuses on addressing symptoms ... In cases of immune-mediated diseases, such as relapsing polychondritis, they can help prevent relapses of the disease or ... Relapsing polychondritis. (2018).. https://rarediseases.org/rare-diseases/relapsing-polychondritis/. *. What you need to know ...
Relapsing polychondritis (RP) is a severe, episodic, and progressive inflammatory condition involving cartilaginous structures ... encoded search term (Relapsing Polychondritis) and Relapsing Polychondritis What to Read Next on Medscape ... 8] A report of relapsing polychondritis in the newborn of a mother with relapsing polychondritis suggests that antibodies ... the 5-year survival rate associated with relapsing polychondritis was reported to be 66%-74% (45% if relapsing polychondritis ...
Relapsing polychondritis. (2018).. https://rarediseases.org/rare-diseases/relapsing-polychondritis/. *. Sharma A, et al. (2019 ... Relapsing polychondritis usually begins with sudden pain or tenderness in the cartilage in one or both ears. Flare-ups may last ... of people with relapsing polychondritis. Usually, the hard part of your external ear is affected and your ear lobe is spared. ... Doctors usually diagnose relapsing polychondritis based on your signs and symptoms. Three out of six. of the following six ...
Relapsing polychondritis is a rare disease of unknown etiology. There are approximately 211 reported cases in the world ... Relapsing polychondritis--report of ten cases Laryngoscope. 1979 Jun;89(6 Pt 1):929-46. ... Relapsing polychondritis is a rare disease of unknown etiology. There are approximately 211 reported cases in the world ...
Relapsing polychondritis (RP) is a severe, episodic, and progressive inflammatory condition involving cartilaginous structures ... encoded search term (Relapsing Polychondritis) and Relapsing Polychondritis What to Read Next on Medscape ... Cutaneous polyarteritis nodosa: A patient with relapsing polychondritis presented with relapsing painful red nodules from 1-3 ... of the many conditions associated with relapsing polychondritis rather than specific manifestations of relapsing polychondritis ...
Relapsing polychondritis (RP) is a severe, episodic, and progressive inflammatory condition involving cartilaginous structures ... encoded search term (Relapsing Polychondritis) and Relapsing Polychondritis What to Read Next on Medscape ... Relapsing polychondritis is a complex condition that requires a team approach for patient care, as follows:. * Dermatologists ... Relapsing Polychondritis Treatment & Management. Updated: Oct 12, 2022 * Author: Nicholas Compton, MD; Chief Editor: Herbert S ...
Although the survival rates of patients with relapsing polychondritis (RP) have increased remarkably, the high recurrence rate ... The Relapsing polychondritis Disease Activity Index: development of a disease activity score for relapsing polychondritis. ... which could affect relapse. Second, there is no established definition of RP relapse; thus, we developed our own relapse ... Relapsing polychondritis is a rare disease that causes inflammation of the chondrocytes of the ear, nose, and trachea, and it ...
Relapsing polychondritis (RP) is a severe, episodic, and progressive inflammatory condition involving cartilaginous structures ... encoded search term (Relapsing Polychondritis) and Relapsing Polychondritis What to Read Next on Medscape ... 8] A report of relapsing polychondritis in the newborn of a mother with relapsing polychondritis suggests that antibodies ... the 5-year survival rate associated with relapsing polychondritis was reported to be 66%-74% (45% if relapsing polychondritis ...
Pages that link to "Ocular Manifestations of Relapsing Polychondritis". From EyeWiki. ← Ocular Manifestations of Relapsing ... Retrieved from "https://eyewiki.org/Special:WhatLinksHere/Ocular_Manifestations_of_Relapsing_Polychondritis" ...
"Polychondritis, Relapsing." Quick Medical Diagnosis & Treatment 2023 Papadakis MA, McPhee SJ. Papadakis M.A., & McPhee S.J.(Eds ... Polychondritis, Relapsing. In: Papadakis MA, McPhee SJ. Papadakis M.A., & McPhee S.J.(Eds.),Eds. Maxine A. Papadakis, and ... Polychondritis, relapsing. Papadakis MA, McPhee SJ. Papadakis M.A., & McPhee S.J.(Eds.),Eds. Maxine A. Papadakis, and Stephen J ...
Watch relapsing polychondritis rheumatology animation involving easy and quick overview of the questions raised in previous ...
Never give up. Even if you feel defeated, you can proudly say you fought a good fight." Hi everyone, I am Koh Jia En Jenny, 38 years ...
Relapsing polychondritis (RP) is a severe, episodic, and progressive inflammatory condition involving cartilaginous structures ... encoded search term (Relapsing Polychondritis) and Relapsing Polychondritis What to Read Next on Medscape ... 8] A report of relapsing polychondritis in the newborn of a mother with relapsing polychondritis suggests that antibodies ... The 5-year survival rate associated with relapsing polychondritis has been reported to be 66-74% (45% if relapsing ...
The frustration I experience is because no specific test is used to confirm a Relapsing Polychondritis diagnosis. A doctor ... Relapsing Polychondritis by red, inflammation of the cartilage. If a ... Health Reference My experience with Relapsing Polychondritis testing is full of frustration. ... HypoGal shares Relapsing Polychondritis Testing. Tests include lab work for R.P., Pulmonary Function Test, and Echocardiogram. ...
The Relapsing Polychondritis Foundation connected Dan Smith with Dr. Marcela Ferrada, a doctor at the National Institutes of ... "Relapsing polychondritis is a very hard disease to figure out and thats where the Relapsing Polychondritis Foundation and the ... The Relapsing Polychondritis Foundation, Inc. is a nonprofit 501(c)3 corporation. Donations are tax deductible as allowed by ... Thats when his wife found the Relapsing Polychondritis Foundation. She reached out to us and explained Dans situation. We ...
Driving awareness about relapsing polychondritis and autoimmune diseases. Accelerating research in pursuit of a cure. ... Relapsing Polychondritis Foundation Renews Partnership with NYU Grossman School of Medicine to Invest in Next Phase of VEXAS ... New Study by Relapsing Polychondritis Foundation Research Partners Shows VEXAS Syndrome May Be More Common Than Many Other ... Relapsing polychondritis (RP) is a severe, chronic autoimmune disease marked by the inflammation and breakdown of cartilage. ...
Relapsing Polychondritis Foundation Announces Appointment of Frances Sweeney to Board of Directors. The Relapsing ... This information is from the Relapsing Polychondritis Foundation Inc. (RP Foundation) with Race for RP. The Relapsing ... Relapsing Polychondritis Foundation Renews Partnership with NYU Grossman School of Medicine to Invest in Next Phase of VEXAS ... The Relapsing Polychondritis (RP) Foundation is pleased to announce it will continue and expand its partnership with NYU ...
Relapsing polychondritis is an autoimmune disorder that presents with non-specific symptoms affecting the neck, nose, throat, ... What causes relapsing polychondritis?. No one knows why relapsing polychondritis occurs, but it is suspected to have an ... Prevalence of relapsing polychondritis. While considered a rare disease, cases of relapsing polychondritis have been estimated ... Treating relapsing polychondritis. Unfortunately, there is no cure for relapsing polychondritis. Therefore, the main mode of ...
A case of relapsing polychondritis developing tracheomalacia Suzan Temiz1,Omer Faruk Demir1,Omer Onal1,Leyla Hasdiraz1,Fahri ... Here we present a rare case of a 43-year-old female with relapsing polychondritis with tracheal involvement. Keywords : ... There are limited data on the relapsing polychondritis (RP). RP is an uncommon autoimmune disorder that is characterized by ... A case of relapsing polychondritis developing tracheomalacia ...
Relapsing Polychondritis - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the MSD Manuals - Medical ... Prognosis for Relapsing Polychondritis Mortality rates have decreased with newer therapies. Survival is now 94% after 8 years, ... Treatment of Relapsing Polychondritis *. Nonsteroidal anti-inflammatory drugs or dapsone for mild ear disease ... Relapsing polychondritis affects men and women equally; onset typically is in middle age. An association with rheumatoid ...
Relapsing Polychondritis. Using data-driven classification, we identified three subgroups of patients with relapsing ... Ultra-rare genetic variation in relapsing polychondritis: a whole-exome sequencing study. Luo Y, Ferrada MA, Sikora KA, Rankin ... Somatic Mutations in UBA1 Define a Distinct Subset of Relapsing Polychondritis Patients With VEXAS. Ferrada MA, Sikora KA, Luo ... From these efforts, we have published some of the only observational cohort data in relapsing polychondritis. Using latent ...
Relapsing polychondritis (RPC) is a rare progressive autoimmune disease that causes inflammation in the cartilage of multiple ... A case of localized tracheobronchial relapsing polychondritis with positive matrilin-1 staining. BMC Rheumatol. 2020. ...
Rapini (2006). "Relapsing polychondritis". Clin. Dermatol. 24 (6): 482-5. doi:10.1016/j.clindermatol.2006.07.018. PMID 17113965 ... present in the setting of nontraumatic inflammatory injury of auricular connective tissue such as in relapsing polychondritis ( ...
February-March 2014). "Diagnosis and classification of relapsing polychondritis". Journal of Autoimmunity. 48-49: 53-59. doi: ... Puéchal X, Terrier B, Mouthon L, Costedoat-Chalumeau N, Guillevin L, Le Jeunne C (March 2014). "Relapsing polychondritis". ... including relapsing polychondritis, rheumatoid arthritis, granulomatosis with polyangiitis, and systemic lupus erythematosus.[ ...
Relapsing polychondritis. *Vasculitis. When a specific disease cannot be diagnosed, more general terms may be used. These are ...
Relapsing polychondritis. Anterior. Unknown. Inflammation of cartilaginous tissues. -. Often associated with scleritis, ... Multifocal disease of white matter of brain; chronic remitting and relapsing course. MRI, CSF examination. - ...
Relapsing Polychondritis. *Retroperitoneal Fibrosis. *Rheumatoid Arthritis. *Rheumatoid Arthritis and Heart Disease * ...
Palmerlee has a rare autoimmune disease called relapsing polychondritis. It attacks her cartilage, and among other things, ...
  • The Relapsing Polychondritis Foundation (RP Foundation) is pleased to announce the appointment of Frances "Fran" Sweeney to its Board of Directors effective December 11, 2022. (polychondritis.org)
  • In 2022, the Relapsing Polychondritis Foundation, Race for RP, and our incredible partners helped drive RP and related autoimmune diseases to the forefront of ground-breaking scientific discoveries. (polychondritis.org)
  • Relapsing polychondritis is a multi-systemic condition characterized by repeated episodes of inflammation and deterioration of cartilage. (wikipedia.org)
  • Though any cartilage in the body may be affected in persons with relapsing polychondritis, in many cases the disease affects several areas while sparing others. (wikipedia.org)
  • Cartilage inflammation (technically known as chondritis) that is relapsing is very characteristic of the disease and is required for the diagnosis of RP. (wikipedia.org)
  • Relapsing polychondritis is a rare immune-mediated degenerative disease that causes cartilage inflammation in a person's body, including the ears and nose. (medicalnewstoday.com)
  • In cases of immune-mediated diseases, such as relapsing polychondritis, they can help prevent relapses of the disease or further damage to the joints or cartilage. (medicalnewstoday.com)
  • Relapsing polychondritis is a rare disease that causes inflammation of your cartilage. (healthline.com)
  • Researchers don't clearly understand why some people develop the rare inflammatory disease known as relapsing polychondritis, but they believe it occurs when your immune cells attack healthy cartilage cells. (healthline.com)
  • Polychondritis" means that it causes problems with many different areas of cartilage. (healthline.com)
  • Relapsing polychondritis usually begins with sudden pain or tenderness in the cartilage in one or both ears . (healthline.com)
  • The specificity of autoimmune injury to cartilaginous tissues has led investigators to test the hypothesis that a cartilage-specific autoantibody is central to the pathogenesis of relapsing polychondritis. (medscape.com)
  • Various studies find circulating antibodies to cartilage-specific collagen types II, IX, and XI to be present in 30%-70% of patients with relapsing polychondritis. (medscape.com)
  • Furthermore, levels of antibodies to matrilin 1, an extracellular matrix protein predominantly expressed in tracheal cartilage, were significantly higher in patients with relapsing polychondritis, especially in those with respiratory symptoms, than in patients with Wegener granulomatosis , systemic lupus erythematosus , or RA and in healthy controls. (medscape.com)
  • Most patients with relapsing polychondritis had high titers of antifetal cartilage antibodies during the early acute phase. (medscape.com)
  • A doctor could recognize that a patient may have the rare disease, Relapsing Polychondritis by red, inflammation of the cartilage. (hypogalblog.com)
  • The doctor may also ask that suspicious Relapsing Polychondritis tissue cartilage is biopsied. (hypogalblog.com)
  • Relapsing polychondritis (RP) is a severe, chronic autoimmune disease marked by the inflammation and breakdown of cartilage. (raceforrp.org)
  • Relapsing polychondritis (RPC) is a rare progressive autoimmune disease that causes inflammation in the cartilage of multiple organs, with tracheobronchial involvement appearing in nearly half of all cases. (medjournal360.com)
  • Cauliflower ear can also present in the setting of nontraumatic inflammatory injury of auricular connective tissue such as in relapsing polychondritis (RP), a rare rheumatologic disorder in which recurrent episodes of inflammation result in destruction of cartilage of the ears and nose. (wikipedia.org)
  • Relapsing polychondritis is an autoimmune disease that affects the cartilage in the body. (tripod.com)
  • We're honored to support the Relapsing Polychondritis Warrior 5k Walk organized by RP Warrior, Dan Smith. (raceforrp.org)
  • Relapsing polychondritis is a very hard disease to figure out and that's where the Relapsing Polychondritis Foundation and the Race for RP really come in to play. (polychondritis.org)
  • New York - October 18, 2023 - This information is from the Relapsing Polychondritis Foundation Inc. (RP Foundation) with Race for RP. (polychondritis.org)
  • New York - January 25, 2023 - This information is from the Relapsing Polychondritis Foundation Inc. (RP Foundation) with Race for RP. (polychondritis.org)
  • Race for RP is a partnership with race car drivers, teams, owners, sponsors, and enthusiasts to drive awareness and accelerate research for relapsing polychondritis (RP) and other autoimmune diseases. (raceforrp.org)
  • The Race for RP and the Relapsing Polychondritis Foundation are accelerating research and studies to help diagnose, prevent and cure relapsing polychondritis and related autoimmune diseases. (raceforrp.org)
  • People with relapsing polychondritis have flare-ups of pain or swelling in the affected areas followed by periods of remission where symptoms subside. (healthline.com)
  • Relapsing" means the condition causes reoccurring flare-ups of symptoms. (healthline.com)
  • Ear symptoms develop in about 90% of people with relapsing polychondritis. (healthline.com)
  • More than 50% of people with relapsing polychondritis develop nose symptoms at some point. (healthline.com)
  • Doctors usually diagnose relapsing polychondritis based on your signs and symptoms. (healthline.com)
  • The array of possible presenting symptoms and the episodic nature of relapsing polychondritis may result in a significant delay in diagnosis. (medscape.com)
  • If a patient presents respiratory symptoms and is confirmed or is suspected to have Relapsing Polychondritis, then a doctor may order (PFT) Pulmonary Function Tests. (hypogalblog.com)
  • Relapsing polychondritis is an autoimmune disorder that presents with non-specific symptoms affecting the neck, nose, throat, and ears. (belmarrahealth.com)
  • What are the symptoms of relapsing polychondritis? (belmarrahealth.com)
  • Because collagen is present throughout the body, the symptoms of relapsing polychondritis may present in several different ways. (belmarrahealth.com)
  • A biopsy can help rule out other causes of the presenting symptoms and can confirm polychondritis. (belmarrahealth.com)
  • After years of painful and debilitating symptoms with no clear cause, Nancy was diagnosed with relapsing polychondritis. (raceforrp.org)
  • Both ears are often affected but the inflammation may alternate between either ear during a relapse. (wikipedia.org)
  • Because this disease is relapsing, recurrent laryngeal inflammation may result in laryngomalacia or permanent laryngeal stenosis with inspiratory dyspnea that may require emergency tracheotomy as a temporary or permanent measure. (wikipedia.org)
  • Relapsing polychondritis is a rare disease that causes inflammation of the chondrocytes of the ear, nose, and trachea, and it can affect any organ of the body [ 1 ]. (springer.com)
  • Relapsing polychondritis (RP) is a severe, episodic, and progressive inflammatory condition involving cartilaginous structures, predominantly those of the ears, nose, and laryngotracheobronchial tree. (medscape.com)
  • Here we present a rare case of a 43-year-old female with relapsing polychondritis with tracheal involvement. (tgcd.org.tr)
  • Relapsing polychondritis is a rare disease of unknown etiology. (nih.gov)
  • [ 8 ] A report of relapsing polychondritis in the newborn of a mother with relapsing polychondritis suggests that antibodies crossing the placenta are necessary and sufficient to elicit the entire clinical syndrome. (medscape.com)
  • Dapsone (25-200 mg/d) has been beneficial in some patients with mild relapsing polychondritis, although more current clinical experience has found dapsone to be less useful. (medscape.com)
  • Healthcare professionals might recommend surgery to replace heart valves where relapsing polychondritis affects the heart valves . (medicalnewstoday.com)
  • In addition, no laboratory findings are specific for relapsing polychondritis. (medscape.com)
  • Our world-renowned research partners are driving ground-breaking discoveries in relapsing polychondritis and related autoimmune disease research. (raceforrp.org)
  • If Anemia normochromic and normocytic is present, there is an association with a poor prognosis with Relapsing Polychondritis. (hypogalblog.com)
  • No one knows why relapsing polychondritis occurs, but it is suspected to have an autoimmune association. (belmarrahealth.com)
  • Researchers have found that antibodies to type II collagen are present during acute relapsing polychondritis episodes and that the levels correlate with the severity of the episode. (medscape.com)
  • They are more likely to be found in association with antibodies to type II collagen in patients with relapsing polychondritis. (medscape.com)
  • A healthcare professional may recommend a person uses them for mild cases of relapsing polychondritis to help control pain and swelling. (medicalnewstoday.com)
  • That's when his wife found the Relapsing Polychondritis Foundation. (polychondritis.org)
  • The Relapsing Polychondritis Foundation, Inc. is a nonprofit 501(c)3 corporation. (polychondritis.org)
  • The Relapsing Polychondritis (RP) Foundation is pleased to announce the release of The Race of Our Lives, a documentary directed by Roy Medawar. (polychondritis.org)
  • The Relapsing Polychondritis (RP) Foundation is pleased to announce it will continue and expand its partnership with NYU Grossman School of Medicine to invest in and advance the next phase of collaborative VEXAS research. (polychondritis.org)
  • You are being redirected to the Relapsing Polychondritis Foundation donation page. (raceforrp.org)
  • An even more rewarding and profound one, namely focusing on autoimmune disease education with my Relapsing Polychondritis Foundation. (ferraribeverlyhills.com)
  • Relapsing polychondritis can be difficult to diagnose since no single blood or imaging test can provide a definitive diagnosis. (healthline.com)
  • Diagnostic criteria for relapsing polychondritis first were proposed by McAdam et al and have been modified several times. (medscape.com)
  • [ 19 ] In fact, one third of patients with diagnosed relapsing polychondritis see five or more physicians before the correct diagnosis is made. (medscape.com)
  • Older male patients with relapsing polychondritis who develop macrocytic anemia and thrombocytopenia may have VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome, a rare disorder caused by a mutation in the UBA1 gene that encodes the enzyme-1-activating enzyme (E1) involved in intracellular destruction of defective proteins. (msdmanuals.com)
  • Of patients with relapsing polychondritis, 85%-95% develop auricular chondritis. (medscape.com)
  • While considered a rare disease, cases of relapsing polychondritis have been estimated as being 0.71, 2.0, and 3.5 cases per million in the United Kingdom, Hungary, and Minnesota, respectively. (belmarrahealth.com)
  • Palmerlee has a rare autoimmune disease called relapsing polychondritis. (npr.org)
  • At the same time that I began racing, my wife Nancy was diagnosed with a rare autoimmune disease, Relapsing Polychondritis (RP) which is sometimes fatal. (ferraribeverlyhills.com)
  • Relapsing Polychondritis has links to many multisystemic diseases. (hypogalblog.com)
  • We have never lost sight of our purpose and have become a catalyst for awareness and research on treatments and cures for relapsing polychondritis and related autoimmune diseases. (raceforrp.org)
  • Wierzbicka et al reported good airway patency for more than 24 months in eight of 12 patients with relapsing polychondritis or other autoimmune disorders treated with this approach. (medscape.com)
  • The benefits of any proposed surgery must be weighed adequately against the patient's risk for infection, especially in the event of acute relapse, since patients are at an increased risk of infection whether or not they are using corticosteroids. (medscape.com)
  • Although the survival rates of patients with relapsing polychondritis (RP) have increased remarkably, the high recurrence rate remains a significant concern for physicians and patients. (springer.com)
  • In 50 percent of Relapsing Polychondritis patients, there is confirmation of thrombocytosis, leukocytosis, and normochromic normocytic anemia. (hypogalblog.com)
  • I hope you have found these Relapsing Polychondritis Testing health references helpful. (hypogalblog.com)
  • McAdam et al found that continuous prednisone decreased the severity, frequency, and duration of relapses. (medscape.com)
  • The Ride of My Life documentary features Nancy Linn's journey toward being diagnosed with Relapsing Polychondritis and her commitment to turn this potentially dire diagnosis into something positive by "living with purpose. (polychondritis.org)
  • According to a 2018 updated review , heart valve issues affect about 10% of people with relapsing polychondritis. (medicalnewstoday.com)
  • The outlook for people with relapsing polychondritis tends to be good. (healthline.com)
  • Cardiovascular problems develop in 25% to 50% of people with relapsing polychondritis and can be serious. (healthline.com)
  • Twenty-five to thirty-five percent of people suffering from relapsing polychondritis also suffer from other autoimmune disorders. (belmarrahealth.com)
  • A doctor will likely want to perform a computed tomography (CT) scan to look for airway changes if they suspect you have relapsing polychondritis. (healthline.com)
  • No controlled trials of therapy for relapsing polychondritis (RP) have been published. (medscape.com)
  • The condition may also be linked to certain gene mutations, however, relapsing polychondritis doesn't seem to run in families. (belmarrahealth.com)
  • The frustration I experience is because no specific test is used to confirm a Relapsing Polychondritis diagnosis. (hypogalblog.com)
  • Join us in driving awareness and accelerating research for Relapsing Polychondritis. (raceforrp.org)