Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)
'Oral Submucous Fibrosis' is a chronic, insidious, and potentially disabling condition, characterized by progressive stiffness and loss of elasticity of the oral mucosa, due to fibrotic changes in the lamina propria, often associated with juxta-epithelial inflammation and epithelial atrophy.
A megaloblastic anemia occurring in children but more commonly in later life, characterized by histamine-fast achlorhydria, in which the laboratory and clinical manifestations are based on malabsorption of vitamin B 12 due to a failure of the gastric mucosa to secrete adequate and potent intrinsic factor. (Dorland, 27th ed)
Tumors or cancer of the MOUTH.
Tumors or cancer of the STOMACH.
A condition in which there is a change of one adult cell type to another similar adult cell type.
GASTRITIS with atrophy of the GASTRIC MUCOSA, the GASTRIC PARIETAL CELLS, and the mucosal glands leading to ACHLORHYDRIA. Atrophic gastritis usually progresses from chronic gastritis.
Tumors or cancer of the UTERINE CERVIX.
A white patch seen on the oral mucosa. It is considered a premalignant condition and is often tobacco-induced. When evidence of Epstein-Barr virus is present, the condition is called hairy leukoplakia (LEUKOPLAKIA, HAIRY).
A white patch lesion found on a MUCOUS MEMBRANE that cannot be scraped off. Leukoplakia is generally considered a precancerous condition, however its appearance may also result from a variety of HEREDITARY DISEASES.
Instruments inserted into the vagina for examination of the tissues of the vagina and cervix by means of a magnifying lens.
Endoscopic examination, therapy or surgery of the interior of the stomach.
Clusters of colonic crypts that appear different from the surrounding mucosa when visualized after staining. They are of interest as putative precursors to colorectal adenomas and potential biomarkers for colorectal carcinoma.

Helicobacter pylori infection, garlic intake and precancerous lesions in a Chinese population at low risk of gastric cancer. (1/3798)

BACKGROUND: Cangshan County of Shandong Province has one of the lowest rates of gastric cancer (GC) in China. While intestinal metaplasia (IM) and dysplasia (DYS) are less common in Cangshan than in areas of Shandong at high risk of GC, these precursor lesions nevertheless affect about 20% of adults age > or = 55. SUBJECTS AND SETTING: In order to evaluate determinants of IM and DYS in Cangshan County, a low risk area of GC a survey was conducted among 214 adults who participated in a gastroscopic screening survey in Cangshan County in 1994. METHOD: A dietary interview and measurement of serum Helicobacter pylori antibodies were performed. RESULTS: The prevalence of H. pylori was lowest (19%) among those with normal gastric mucosa, rising steadily to 35% for superficial gastritis (SG), 56% for chronic atrophic gastritis (CAG), 80% for IM, and 100% for DYS. The prevalence odds of precancerous lesions were compared with the odds of normal histology or SG. The odds ratio (OR) or CAG associated with H. pylori positivity was 4.2 (95% confidence interval [CI] : 1.7-10.0), while the OR of IM/DYS associated with H. pylori positivity was 31.5 (95% CI: 5.2-187). After adjusting for H. pylori infection, drinking alcohol was a risk factor for CAG (OR = 3.2, 95% CI: 1.1-9.2) and IM/DYS (OR = 7.8, 95% CI: 1.3-47.7). On the other hand, consumption of garlic showed non-significant protective effects and an inverse association with H. pylori infection. CONCLUSIONS: The findings of this study suggest that infection with H. pylori is a risk factor and garlic may be protective, in the development and progression of advanced precancerous gastric lesions in an area of China at relatively low risk of GC.  (+info)

Precancerous lesions in two counties of China with contrasting gastric cancer risk. (2/3798)

BACKGROUND: Gastric cancer (GC) is one of the most common cancers worldwide and shows remarkable geographical variation even within countries such as China. Linqu County in Shandong Province of northeast China has a GC rate that is 15 times higher than that of Cangshan County in Shandong, even though these counties are within 200 miles of each other. METHOD: In order to evaluate the frequency of precancerous gastric lesions in Linqu and Cangshan Counties we examined 3400 adults in Linqu County and 224 adults in Cangshan County. An endoscopic examination with four biopsies was performed in each individual of the two populations. RESULTS: The prevalence of intestinal metaplasia (IM) and dysplasia (DYS) was 30% and 15.1%, respectively, in Linqu compared to 7.9% and 5.6% in Cangshan (P < 0.01). Within these histological categories, advanced grades were found more often in Linqu than in Cangshan. The prevalences of IM and DYS were more common at each biopsy site in Linqu, where the lesions also tended to affect multiple sites. CONCLUSIONS: The findings of this study support the concept that IM and DYS are closely correlated with risks of GC and represent late stages in the multistep process of gastric carcinogenesis.  (+info)

Cervicovaginal human papillomavirus infection in human immunodeficiency virus-1 (HIV)-positive and high-risk HIV-negative women. (3/3798)

BACKGROUND: Human papillomavirus (HPV) infection is associated with precancerous cervical squamous intraepithelial lesions commonly seen among women infected with human immunodeficiency virus-1 (HIV). We characterized HPV infection in a large cohort of HIV-positive and HIV-negative women participating in the Women's Interagency HIV Study to determine the prevalence of and risk factors for cervicovaginal HPV infection in HIV-positive women. METHODS: HIV-positive (n = 1778) and HIV-negative (n = 500) women were tested at enrollment for the presence of HPV DNA in a cervicovaginal lavage specimen. Blood samples were tested for HIV antibody status, level of CD4-positive T cells, and HIV RNA load (copies/mL). An interview detailing risk factors was conducted. Univariate and multivariate analyses were performed. RESULTS: Compared with HIV-negative women, HIV-positive women with a CD4+ cell count of less than 200/mm3 were at the highest risk of HPV infection, regardless of HIV RNA load (odds ratio [OR] = 10.13; 95% confidence interval [CI] = 7.32-14.04), followed by women with a CD4+ count greater than 200/mm3 and an HIV RNA load greater than 20,000 copies/mL (OR = 5.78; 95% CI = 4.17-8.08) and women with a CD4+ count greater than 200/mm3 and an HIV RNA load less than 20,000 copies/mL (OR = 3.12; 95% CI = 2.36-4.12), after adjustment for other factors. Other risk factors among HIV-positive women included racial/ethnic background (African-American versus Caucasian, OR = 1.64; 95% CI = 1.19-2.28), current smoking (yes versus no; OR = 1.55; 95% CI = 1.20-1.99), and younger age (age < 30 years versus > or = 40 years; OR = 1.75; 95% CI = 1.23-2.49). CONCLUSIONS: Although the strongest risk factors of HPV infection among HIV-positive women were indicators of more advanced HIV-related disease, other factors commonly found in studies of HIV-negative women, including racial/ethnic background, current smoking, and age, were important in HIV-positive women as well.  (+info)

Differential responses of normal, premalignant, and malignant human bronchial epithelial cells to receptor-selective retinoids. (4/3798)

Using an in vitro lung carcinogenesis model consisting of normal, premalignant, and malignant human bronchial epithelial (HBE) cells, we analyzed the growth inhibitory effects of 26 novel synthetic retinoic acid receptor (RAR)- and retinoid X receptor (RXR)-selective retinoids. RAR-selective retinoids such as CD271, CD437, CD2325, and SR11364 showed potent activity in inhibiting the growth of either normal or premalignant and malignant HBE cells (IC50s mostly <1 microM) and were much more potent than RXR-selective retinoids. Nonetheless, the combination of RAR- and RXR-selective retinoids exhibited additive effects in HBE cells. As the HBE cells became progressively more malignant, they exhibited decreased or lost sensitivity to many retinoids. The activity of the RAR-selective retinoids, with the exception of the most potent retinoid, CD437, could be suppressed by an RAR panantagonist. These results suggest that: (a) RAR/RXR heterodimers play an important role in mediating the growth inhibitory effects of most retinoids in HBE cells; (b) CD437 may act through an RAR-independent pathway; (c) some of the RAR-selective retinoids may have the potential to be used in the clinic as chemopreventive and chemotherapeutic agents for lung cancer; and (d) early stages of lung carcinogenesis may be responsive targets for chemoprevention by retinoids, as opposed to later stages.  (+info)

KRAS mutations predict progression of preneoplastic gastric lesions. (5/3798)

Eight hundred sixty-three subjects with atrophic gastritis were recruited to participate in an ongoing chemoprevention trial in Narino, Colombia. The participants were randomly assigned to intervention therapies, which included treatment to eradicate Helicobacter pylori infection followed by daily dietary supplementation with antioxidant micronutrients in a 2 x 2 x 2 factorial design. A series of biopsies of gastric mucosa were obtained according to a specified protocol from designated locations in the stomach for each participant at baseline (before intervention therapy) and at year three. A systematic sample of 160 participants was selected from each of the eight treatment combinations. DNA was isolated from each of these biopsies (n = 320), and the first exon of KRAS was amplified using PCR. Mutations in the KRAS gene were detected using denaturing gradient gel electrophoresis and confirmed by sequence analysis. Of all baseline biopsies, 14.4% (23 of 160) contained KRAS mutations. Among those participants with atrophic gastritis without metaplasia, 19.4% (6 of 25) contained KRAS mutations, indicating that mutation of this important gene is likely an early event in the etiology of gastric carcinoma. An important association was found between the presence of KRAS mutations in baseline biopsies and the progression of preneoplastic lesions. Only 14.6% (20 of 137) of participants without baseline KRAS mutations progressed from atrophic gastritis to intestinal metaplasia or from small intestinal metaplasia to colonic metaplasia; however, 39.1% (9 of 23) with baseline KRAS mutations progressed to a more advanced lesion after 3 years [univariate odds ratio (OR), 3.76 (P = 0.05); multivariate OR adjusted for treatment, 3.74 (P = 0.04)]. In addition, the specificity of the KRAS mutation predicted progression. For those participants with G-->T transversions at position 1 of codon 12 (GGT-->TGT), 19.4% (5 of 17) progressed (univariate OR, 2.4); however, 60.0% (3 of 5) of participants with G-->A transitions at position 1 of codon 12 (GGT-->AGT) progressed (univariate OR, 8.7; P = 0.004 using chi2 test).  (+info)

Resistance to mammary tumorigenesis in Copenhagen rats is associated with the loss of preneoplastic lesions. (6/3798)

The resistance of Copenhagen (Cop) rats to mammary tumor development has recently been linked to three loci, but the genes have yet to be cloned and the mechanism of resistance is still largely unknown. In order to determine the cellular events associated with resistance, we prepared mammary whole mounts from Cop and susceptible Wistar Furth (WF) rats 0, 15, 30, 45 and 60 days after treatment with 50 mg/kg N-methyl-N-nitrosourea (MNU). At 15 days, treated rats of both strains had significantly more undifferentiated structures [terminal end buds (TEBs)] and significantly fewer differentiated structures [alveolar buds (ABs)] than untreated rats. Treated Cop rats, however, had significantly more TEBs and fewer ABs than age-matched, treated WF rats. Histological analysis of preneoplastic lesions tentatively identified from the whole mounts showed that like WF rats, Cop rats developed early preneoplastic lesions [intraductal proliferations (IDPs)] by 15 days post-MNU treatment. Unlike IDPs from WF rats, however, the IDPs in Cop rats then decreased in number until they were absent 60 days post-MNU treatment. Furthermore, they failed to progress into more advanced lesions such as ductal carcinomas in situ (DCIS). Finally, we found G-->A activating mutations in codon 12 of the Ha-ras gene in 60% of IDPs from Cop rats and 75% of IDPs from WF rats. Our results show that resistance in Cop rats is not due to a target cell population for the carcinogen that is smaller than in susceptible rats or to the failure of the carcinogen to inhibit mammary gland differentiation. Furthermore, we have shown that Cop rats develop preneoplastic IDPs that harbor Ha-ras mutations but, unlike IDPs in susceptible strains, they fail to progress and ultimately disappear.  (+info)

Effect of retinoids on AOM-induced colon cancer in rats: modulation of cell proliferation, apoptosis and aberrant crypt foci. (7/3798)

We have previously reported that the retinoids, 4-(hydroxyphenyl)retinamide (4-HPR) and 9-cis-retinoic acid (RA) prevented azoxymethane (AOM)-induced colon tumors and along with 2-(carboxyphenyl)retinamide (2-CPR) prevented aberrant crypt foci (ACF). In this study, we evaluated the effect of 2-CPR on AOM-induced colon tumors and the effect of the three retinoids on apoptosis and cell proliferation. Male F344 rats were administrated 15 mg/kg AOM at weeks 7 and 8 of age. 2-CPR (315 mg/kg) was administered in the diet starting either 1 week before or at week 12 after the first dose of AOM. The rats continued to receive the 2-CPR until killed at week 46. Unlike the demonstrated prevention of colon cancer by the other two retinoids, both dosing schedules of 2-CPR resulted in an approximate doubling of the yield of colon tumors. In adenomas, 2-CPR, 4-HPR and 9-cis-RA were equally effective in reducing mitotic activity, while only 4-HPR and 9-cis-RA but not 2-CPR enhanced apoptosis. When administered for only the 6 days prior to killing 4-HPR but not 2-CPR decreased the Mitotic Index and increased the Apoptotic Index in adenomas. In non-involved crypts, chronic exposure to 4-HPR and 9-cis-RA in contrast to 2-CPR reduced the Mitotic Index and enhanced the Apoptotic Index. In concurrence with our previous study, both 2-CPR and 4-HPR were very potent in preventing ACF when administered in the diet starting 1 week before the first dose of AOM and continuing for the 5 weeks of the study. Hence, unlike the other two retinoids, 2-CPR, although very potent in preventing ACF, enhanced rather than prevented AOM-induced colon cancer. Furthermore, our results suggest that the effect of 2-CPR on tumor yield is different from 4-HPR and 9-cis-RA because, unlike them, it does not enhance apoptosis.  (+info)

Apoptotic activity is increased in parallel with the metaplasia-dysplasia-carcinoma sequence of the bronchial epithelium. (8/3798)

A high level of apoptotic activity and an independence of apoptosis from the expression of p53 and bcl-2 have been observed in non-small-cell lung carcinoma. We examined 44 samples of normal, metaplastic and premalignant (i.e. mild, moderate and severe dysplasias and carcinoma in situ) bronchial epithelia to evaluate whether differences in the apoptotic activity could already be seen in the stages preceding squamous cell carcinoma of the lung (SQCLC). Apoptotic cells and bodies were visualized by 3' end labelling. The expression of p53 and members of the bcl-2 gene family, such as bcl-2, bax and mcl-1, were determined immunohistochemically with specific antibodies. The relative number of apoptotic cells and bodies [apoptotic index (AI%)] was already increased threefold as the normal bronchial epithelium changed to squamous metaplasia, and the AIs of the dysplastic lesions were about four times higher than those of the normal epithelium. Apoptosis was significantly associated with cell proliferation, as determined by proliferating cell nuclear antigen (PCNA) immunohistochemistry. However, the extent of apoptosis did not correlate with the expression of p53, bcl-2, bax and mcl-1. We conclude that, in the metaplasia-dysplasia-carcinoma sequence in the lung, the elevation of the AI% is an early event associated with cell proliferation activity, but is independent of the expression of p53, bcl-2, mcl-1 and bax.  (+info)

A precancerous condition, also known as a premalignant condition, is a state of abnormal cellular growth and development that has a higher-than-normal potential to progress into cancer. These conditions are characterized by the presence of certain anomalies in the cells, such as dysplasia (abnormal changes in cell shape or size), which can indicate an increased risk for malignant transformation.

It is important to note that not all precancerous conditions will eventually develop into cancer, and some may even regress on their own. However, individuals with precancerous conditions are often at a higher risk of developing cancer compared to the general population. Regular monitoring and appropriate medical interventions, if necessary, can help manage this risk and potentially prevent or detect cancer at an early stage when it is more treatable.

Examples of precancerous conditions include:

1. Dysplasia in the cervix (cervical intraepithelial neoplasia or CIN)
2. Atypical ductal hyperplasia or lobular hyperplasia in the breast
3. Actinic keratosis on the skin
4. Leukoplakia in the mouth
5. Barrett's esophagus in the digestive tract

Regular medical check-ups, screenings, and lifestyle modifications are crucial for individuals with precancerous conditions to monitor their health and reduce the risk of cancer development.

Oral Submucous Fibrosis (OSF) is a chronic, progressive, and potentially disabling disease that affects the oral soft tissues. It is characterized by inflammation and fibrosis (excessive deposition of collagen) of the submucosal tissues, leading to stiffness and limitation of mouth opening, tongue movement, and occasionally swallowing or speaking difficulties. The condition primarily affects individuals with a history of areca nut (betel nut) chewing, although other factors such as smoking, alcohol consumption, and genetic predisposition may also contribute to its development. Symptoms can include burning sensation in the mouth, dryness, and pain during speaking, eating, or swallowing. In severe cases, OSF can lead to significant functional impairment and require surgical intervention.

Pernicious anemia is a specific type of vitamin B12 deficiency anemia that is caused by a lack of intrinsic factor, a protein made in the stomach that is needed to absorb vitamin B12. The absence of intrinsic factor leads to poor absorption of vitamin B12 from food and results in its deficiency.

Vitamin B12 is essential for the production of healthy red blood cells, which carry oxygen throughout the body. Without enough vitamin B12, the body cannot produce enough red blood cells, leading to anemia. Pernicious anemia typically develops slowly over several years and can cause symptoms such as fatigue, weakness, pale skin, shortness of breath, and a decreased appetite.

Pernicious anemia is an autoimmune disorder, which means that the body's immune system mistakenly attacks healthy cells in the stomach lining, leading to a loss of intrinsic factor production. It is more common in older adults, particularly those over 60 years old, and can also be associated with other autoimmune disorders such as type 1 diabetes, Hashimoto's thyroiditis, and Addison's disease.

Treatment for pernicious anemia typically involves vitamin B12 replacement therapy, either through oral supplements or injections of the vitamin. In some cases, dietary changes may also be recommended to ensure adequate intake of vitamin B12-rich foods such as meat, fish, poultry, and dairy products.

A mouth neoplasm refers to an abnormal growth or tumor in the oral cavity, which can be benign (non-cancerous) or malignant (cancerous). Malignant mouth neoplasms are also known as oral cancer. They can develop on the lips, gums, tongue, roof and floor of the mouth, inside the cheeks, and in the oropharynx (the middle part of the throat at the back of the mouth).

Mouth neoplasms can have various causes, including genetic factors, tobacco use, alcohol consumption, and infection with human papillomavirus (HPV). Symptoms may include a lump or thickening in the oral soft tissues, white or red patches, persistent mouth sores, difficulty swallowing or speaking, and numbness in the mouth. Early detection and treatment of mouth neoplasms are crucial for improving outcomes and preventing complications.

Stomach neoplasms refer to abnormal growths in the stomach that can be benign or malignant. They include a wide range of conditions such as:

1. Gastric adenomas: These are benign tumors that develop from glandular cells in the stomach lining.
2. Gastrointestinal stromal tumors (GISTs): These are rare tumors that can be found in the stomach and other parts of the digestive tract. They originate from the stem cells in the wall of the digestive tract.
3. Leiomyomas: These are benign tumors that develop from smooth muscle cells in the stomach wall.
4. Lipomas: These are benign tumors that develop from fat cells in the stomach wall.
5. Neuroendocrine tumors (NETs): These are tumors that develop from the neuroendocrine cells in the stomach lining. They can be benign or malignant.
6. Gastric carcinomas: These are malignant tumors that develop from the glandular cells in the stomach lining. They are the most common type of stomach neoplasm and include adenocarcinomas, signet ring cell carcinomas, and others.
7. Lymphomas: These are malignant tumors that develop from the immune cells in the stomach wall.

Stomach neoplasms can cause various symptoms such as abdominal pain, nausea, vomiting, weight loss, and difficulty swallowing. The diagnosis of stomach neoplasms usually involves a combination of imaging tests, endoscopy, and biopsy. Treatment options depend on the type and stage of the neoplasm and may include surgery, chemotherapy, radiation therapy, or targeted therapy.

Metaplasia is a term used in pathology to describe the replacement of one differentiated cell type with another differentiated cell type within a tissue or organ. It is an adaptive response of epithelial cells to chronic irritation, inflammation, or injury and can be reversible if the damaging stimulus is removed. Metaplastic changes are often associated with an increased risk of cancer development in the affected area.

For example, in the case of gastroesophageal reflux disease (GERD), chronic exposure to stomach acid can lead to metaplasia of the esophageal squamous epithelium into columnar epithelium, a condition known as Barrett's esophagus. This metaplastic change is associated with an increased risk of developing esophageal adenocarcinoma.

Atrophic gastritis is a condition characterized by the inflammation and atrophy (wasting away) of the stomach lining, specifically the mucous membrane called the gastric mucosa. This process involves the loss of glandular cells in the stomach, which can result in decreased acid production and potential vitamin B12 deficiency due to reduced intrinsic factor production. Atrophic gastritis can be caused by various factors, including autoimmune disorders, chronic bacterial infection (usually with Helicobacter pylori), and the use of certain medications such as proton pump inhibitors. It can increase the risk of developing stomach cancer, so regular monitoring is often recommended.

Uterine cervical neoplasms, also known as cervical cancer or cervical dysplasia, refer to abnormal growths or lesions on the lining of the cervix that have the potential to become cancerous. These growths are usually caused by human papillomavirus (HPV) infection and can be detected through routine Pap smears.

Cervical neoplasms are classified into different grades based on their level of severity, ranging from mild dysplasia (CIN I) to severe dysplasia or carcinoma in situ (CIN III). In some cases, cervical neoplasms may progress to invasive cancer if left untreated.

Risk factors for developing cervical neoplasms include early sexual activity, multiple sexual partners, smoking, and a weakened immune system. Regular Pap smears and HPV testing are recommended for early detection and prevention of cervical cancer.

Leukoplakia, oral is a predominantly white patch or plaque that cannot be characterized clinically or pathologically as any other disease. It is an oral potentially malignant disorder (OPMD) and represents a significant risk for the development of squamous cell carcinoma. The lesions are typically caused by chronic irritation, such as smoking or smokeless tobacco use, and are most commonly found on the tongue, floor of the mouth, and buccal mucosa. The diagnosis is confirmed through a biopsy, and management includes removal of causative factors and close monitoring for any signs of malignant transformation.

Leukoplakia is a medical term used to describe a white or gray patch that develops on the mucous membranes lining the inside of the mouth. These patches are typically caused by excessive cell growth and cannot be easily scraped off. Leukoplakia is often associated with long-term tobacco use, including smoking and chewing tobacco, as well as alcohol consumption. While most cases of leukoplakia are benign, a small percentage can develop into oral cancer, so it's essential to have any suspicious patches evaluated by a healthcare professional.

A colposcope is a medical device used during a colposcopy exam to help a healthcare professional closely examine the cervix, vagina, and vulva for signs of disease or abnormalities. It's essentially a binocular microscope with a bright light that allows the practitioner to magnify and illuminate the area of interest.

The term 'colposcopes' refers to these medical instruments in general. They are commonly used to investigate abnormal Pap test results, genital warts, cervical dysplasia (precancerous changes in the cells), or other potential issues. The colposcope does not enter the body; it simply provides a magnified view of the external and internal surfaces of the reproductive organs.

Gastroscopy is a medical procedure that involves the insertion of a gastroscope, which is a thin, flexible tube with a camera and light on the end, through the mouth and into the digestive tract. The gastroscope allows the doctor to visually examine the lining of the esophagus, stomach, and duodenum (the first part of the small intestine) for any abnormalities such as inflammation, ulcers, or tumors.

The procedure is usually performed under sedation to minimize discomfort, and it typically takes only a few minutes to complete. Gastroscopy can help diagnose various conditions, including gastroesophageal reflux disease (GERD), gastritis, stomach ulcers, and Barrett's esophagus. It can also be used to take tissue samples for biopsy or to treat certain conditions, such as bleeding or the removal of polyps.

Aberrant crypt foci (ACF) are abnormal, enlarged and dysplastic (abnormally developing) crypts in the lining of the colon or rectum. They are considered to be early preneoplastic lesions, meaning they have the potential to develop into colon cancer. ACF can be detected through a microscopic examination of tissue samples taken during a colonoscopy.

The presence and number of ACF have been associated with an increased risk for developing colorectal cancer. They are often found in individuals with inflammatory bowel disease, particularly those with long-standing ulcerative colitis or Crohn's colitis. The identification and removal of ACF during a colonoscopy may help prevent the development of colorectal cancer.

"Precancerous conditions of the colon or rectum". Canadian cancer society. Retrieved 2018-03-19. "Precancerous conditions of the ... In many cases, individuals with precancerous conditions do not notice any symptoms. Precancerous conditions of the skin or oral ... A precancerous condition is a condition, tumor or lesion involving abnormal cells which are associated with an increased risk ... The term precancerous or premalignant condition may refer to certain conditions, such as monoclonal gammopathy of unknown ...
Precancerous condition Martin LJ (2020). "Cancer Symptoms". WebMD - Cancer Centre. "Cancer statistics". National Cancer ... The term benign in more general medical use characterises a condition or growth that is not cancerous, i.e. does not spread to ... Sometimes the term is used to suggest that a condition is not dangerous or serious. Malignancy in cancers is characterized by ... Malignancy (from Latin male 'badly', and -gnus 'born') is the tendency of a medical condition to become progressively worse; ...
"Precancerous conditions of the skin". Canadian Cancer Society. Retrieved 2020-02-26. Fleming, C. (2010). "How to manage ... When malignant melanocytes from a lentigo maligna have invaded below the epidermis, the condition is termed lentigo maligna ...
"Precancerous conditions of the skin". Canadian Cancer Society. Archived from the original on 3 August 2020. Retrieved 26 ... People with these conditions are unlikely to have the cancer spread to their lymph nodes or anywhere else and have a 5-year ... A number of rare genetic conditions, such as xeroderma pigmentosum, also increase the risk. Diagnosis is by biopsy and analysis ... Mutations that cause the skin condition xeroderma pigmentosum (XP) also increase melanoma susceptibility. Scattered throughout ...
This disease is a potentially precancerous condition. Indolent T-cell lymphoproliferative disorder almost always presents with ... Both of the latter conditions are associated with the development of GI tract lymphomas. However, the relationship of any of ...
It is thus sometimes a precancerous condition. Hackeng WM, Hruban RH, Offerhaus GJ, Brosens LA (2016). "Surgical and molecular ...
"Precancerous conditions of the pancreas - Canadian Cancer Society". www.cancer.ca. Retrieved 5 November 2017. Shibata, Hideki; ... As such IPMN is viewed as a precancerous condition. Once an intraductal papillary mucinous neoplasm has been found, the ...
... is a life-threatening and precancerous condition. The various presentations of GATA2 deficiency include: 1) ... Overall survival in a NIH study using a modest conditioning regimen followed by hematologic stem cell transplantation in GATA2 ... and total body irradiation conditioning followed by allogenic hematopoietic Stem Cell Transplant on 10 patients. The trial had ... and total body irradiation conditioning followed by allogenic hematopoietic stem cell transplantation. ...
He developed keratoses, a pre-cancerous condition of the skin. He related his experience to experts, among them Professor ...
... is a precancerous condition of the breast. It may eventually develop into breast cancer. There are two ...
The procedure is used to test for abnormal, precancerous conditions, or cervical cancer. Moniak CW, Kutzner S, Adam E, Harden J ...
Insights into the Role of Matrix Metalloproteinases in Precancerous Conditions and Colorectal Cancer;. Cancers (Basel). 2021 ... ANRIL as a prognostic biomarker in colon pre-cancerous lesion detection via non-invasive sampling. Genes Genet Syst;. 2022 Apr ...
It is uncommon and a possible indication of a precancerous or cancerous condition. Cells display pagetoid growth when they ...
Elevated TGF-α is associated with Menetrier's disease, a precancerous condition of the stomach. TGF alpha has been shown to ...
Precancerous condition Progressive disease localized disease to spread to other area of the body. The World Food Program and ... Disease is any condition that impairs the normal physical or mental (or both) function of an organism. (Though this definition ... Therefore, every condition an organism does not gain or develop because of inheritance of its parents' genetic information must ... The study reports a small genomic deletion in patients with these neurological conditions. ... "Mutations Not Inherited from ...
She investigated the fine structure of normal, precancerous breast cells under various physiological conditions. She was the ...
... or precancerous conditions. It can be part of a broader urinalysis. If a cancerous condition is detected, other tests and ...
Merino is interested in studying precancerous conditions that may lead to the development of invasive cancers. In 1995, Merino ...
... the Emberger syndrome is a Precancerous condition. The age of onset and types of symptoms that occur in individuals afflicted ...
... is a pre-cancerous condition which occurs when the lining of the anal canal undergoes abnormal changes. It can ...
TMD is a life-threatening, precancerous condition in fetuses as well as infants in their first few months of life. Transient ...
Stage 0 is a pre-cancerous or marker condition, either ductal carcinoma in situ (DCIS) or lobular carcinoma in situ (LCIS). ...
She is an ambassador for the Australian Cervical Cancer Foundation (ACCF), having been treated for the precancerous condition, ...
... (ISLN, also termed in situ lymphoma) is a precancerous condition newly classified by the World ...
Oral submucous fibrosis and lichen planus, which are generally accepted to be precancerous conditions, appear to be related to ...
The main stages are: Stage 0 is a pre-cancerous or marker condition, either ductal carcinoma in situ (DCIS) or lobular ... Carcinoma in situ is growth of low-grade cancerous or precancerous cells within a particular tissue compartment such as the ... Breast changes like atypical ductal hyperplasia and lobular carcinoma in situ, found in benign breast conditions such as ...
... s are associated with lesser incidence of Barrett's esophagus, which is considered to be a pre-cancerous condition ...
... a precancerous condition, are rendered in error. At least 15 - 20% of stomach biopsies have misclassified disease ... Internal medicine physicians treat many gastrointestinal conditions without referral to a gastroenterologist specialist. ...
CD is associated with two grades of disease linked precancerous states. This condition is known as refractory coeliac disease ( ... RCD 1 involves precancerous tissues in which transformed T-cells continue to produce a response even though gluten is no longer ... This can cause addition problems (see:symptoms of IDA and certain conditions like such as Paterson-Brown Kelly (Plummer-Vinson ... In addition to these problems there are a number or rare autoimmune conditions, secondary autoimmunities, such as fibromyalgia ...
... of one tablet twice a day applied topically to the cervices of women with high-grade and low-grade precancerous conditions. ... After three months of treatment, 82.6% of the women who had high-grade disease had normal cervical conditions, confirmed by ...
"Precancerous conditions of the colon or rectum". Canadian cancer society. Retrieved 2018-03-19. "Precancerous conditions of the ... In many cases, individuals with precancerous conditions do not notice any symptoms. Precancerous conditions of the skin or oral ... A precancerous condition is a condition, tumor or lesion involving abnormal cells which are associated with an increased risk ... The term precancerous or premalignant condition may refer to certain conditions, such as monoclonal gammopathy of unknown ...
Pre-cancerous condition was deemed disability under the EqA. News. In Lofty v Hamis t/a First Café, the EAT has set aside an ... pre-cancerous condition and following Ls operations it was confirmed that she had not developed skin cancer. L appealed ... it is not sufficient that he or she might develop a relevant condition in the future. The EAT conceded that a diagnosis of pre ... However, in the view of the tribunal, Ls condition did not amount to cancer for the purposes of that provision: the consultant ...
Referral Patterns for Gynaecologic Cancers and Precancerous Conditions Academic Article * Report of the 2003 Pan-Canadian Forum ... Clinical Practice Guidelines on the Screening and Treatment of Precancerous Lesions for Cervical Cancer Prevention in Saudi ... Quality/Statistical Process Control and Expert-Led Case Review to Increase the Consistency of Diagnostic Rates in Precancerous ...
Discover the connection between HPV infections and the development of precancerous conditions in the male reproductive system. ... Precancerous conditions of the male reproductive organ are often linked to HPV infection.. What is Precancerous states within ... other factors that can predispose individuals to the development of precancerous conditions include conditions like phimosis, ... Here, we delve deeper into what these conditions entail.. The Role of HPV in Precancerous States. *What is HPV, and how does it ...
Precancerous Skin Conditions. Actinic (Solar) Keratosis. Actinic keratosis (also called solar keratosis) is considered to be a ... Skin Conditions that Increase Skin Cancer Risk. Moles (Nevi) and Other Dark Blemishes. Certain moles and dark blemishes ... There is some evidence that long-term treatment for psoriasis and other skin conditions using UVA radiation (PUVA) and UVB may ... Although 80% of melanoma cases develop from brand new lesions or moles, your risk of developing the condition increases if you ...
Precancerous Conditions / diagnosis * Precancerous Conditions / surgery* * Retrospective Studies * Risk Factors ...
The Common Precancerous Skin Condition You Probably Don t Know Here s why you should become familiar with the symptoms of ... Carcinoid Syndrome: A Silent and Serious Digestive Condition About two-thirds of carcinoid tumors occur in the GI tract. Learn ... Nearly one in four women who receive a diagnosis of breast cancer will also develop this second condition. Learn more about the ... This is good news for those with either condition. Heres the update. ...
Intestinal polyps (a pre-cancerous condition). Other causes of GI bleeding may include:. *Abnormal blood vessels in the lining ... Once your condition is stable, you will have a physical exam and a detailed exam of your abdomen. You will also be asked ... GI bleeding may also be a sign of more serious diseases and conditions. These may include cancers of the GI tract, such as:. * ... A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to ...
Precancerous Conditions / chemically induced* * Precancerous Conditions / metabolism * Precancerous Conditions / prevention & ...
Proliferative verrucous leukoplakia and precancerous conditions. In: Barnes L, Eveson JW, Reichart P, Sidranksy D, eds. World ... Yardimci G, Kutlubay Z, Engin B, Tuzun Y. Precancerous lesions of oral mucosa. World J Clin Cases. 2014 Dec 16. 2 (12):866-72. ... Other less-common conditions that also demonstrate an increased risk for malignant transformation include oral submucous ... Axell T, Pindborg JJ, Smith CJ, van der Waal I. Oral white lesions with special reference to precancerous and tobacco- related ...
Leukoplakia can also be a precancerous condition. Persistent patches or other changes in your mouth need a dentists evaluation ... This painless condition occurs when the little bumps on your tongue grow long and trap bacteria that live in your mouth -- ...
LIPA and Precancerous Conditions. View Publications. 4. Breast Cancer. LIPA and Breast Cancer. View Publications. 3. ... Basal p53 levels are tightly suppressed under normal conditions. Disrupting this regulation results in elevated p53 levels to ...
https://www.nhs.uk/conditions/hysterectomy/. *. Procedure price lookup. (n.d.).. https://www.medicare.gov/procedure-price- ...
ZNF217 and Precancerous Conditions. View Publications. 7. Note: list is not exhaustive. Number of papers are based on searches ... Colorectal adenomas are common precancerous lesions with the potential for malignant transformation to colorectal ...
PROSTATE:Flaxseed can reverse a pre-cancerous condition July 2, 2006 Vitamin A - Betacarotene December 6, 2000 ... Breast CancerCancerConditionsWomens HealthYour Body WHAT DOCTORS READ:BREAST CANCER: NO CONSENSUS. What Doctors Dont Tell You ... advice from your physician or other qualified healthcare provider with any questions you may have regarding a medical condition ...
It also can detect precancerous conditions, which can be treated to prevent cancer from occurring. Understanding cancer ...
Some experts argue that rhinophyma is actually a precancerous skin condition.. Talk to your doctor about long-term treatment ... Individuals with this condition are at risk for skin cancer within the affected tissue. The most common type of skin cancer in ... Do you have a red spot on your nose? It could be due to a disease, skin condition, or dry skin. Chances are the spot is not ... The condition gradually develops after the onset of the initial stages of rosacea, which typically happen between the ages of ...
Categories: Precancerous Conditions Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
Lead candidate is in two mid-stage studies for HPV-related conditions. ... Headquartered in Toronto, Helix is developing treatments for cancer and precancerous conditions. The companys lead candidate ... Lead candidate is in two mid-stage studies for HPV-related conditions. ... Sexually transmitted diseasesSystemic conditionsUterine cancerViral diseasesHelix Biopharma ...
Precancerous conditions and epithelial dysplasia in the stomach. J Clin Pathol 33:711-721. ... Altered patterns of mucin secretion in the precancerous lesions induced in the glandular part of the rat stomach by the ... Dysplasia of the gastric mucosa and its relation to the precancerous state. Jpn J Cancer Res 72:813-823. ...
Management of epithelial precancerous conditions and lesions in the stomach (MAPS II): European Society of Gastrointestinal ... Chinese integrated guideline on the management of gastric precancerous conditions and lesions. Chin. Med. 2022, 17, 138. [ ... Based on the recommendations for the management of epithelial precancerous conditions and lesions in the stomach (MAPS II) by ... Precancerous lesions can provide crucial insights into GC development and progression. The absence of such data may affect the ...
This is a pre-cancerous condition and high-grade Barretts esophagus has a 30-40% risk of turning into invasive adenocarcinoma. ... Terms and Conditions under which this service is provided to you. Read our Privacy Policy.. Copyright © 2002 - 2003 eCureMe, ...
Evaluation, biopsy, and treatment of cancerous or pre-cancerous skin conditions, like abnormal moles and lesions. ... Common conditions: vascular conditions, varicose veins Our expert team diagnoses and treats diseases and conditions that affect ... Common conditions: diabetes, thyroid and parathyroid conditions, endocrine conditions We provide caring, expert treatment for ... Common conditions: tinnitus, vertigo, hearing loss, vestibular conditions, swallowing conditions We diagnose and treat ...
Benefits and harms of treatment options for esophageal adenocarcinoma and precancerous conditions: a protocol for an overview ... The most important risk factors for esophageal adenocarcinoma are precancerous conditions (e.g., Barrett esophagus, esophageal ... Benefits and harms of treatment options for esophageal adenocarcinoma and precancerous conditions: an overview of systematic ... Patient values and preferences in relation to screening for esophageal adenocarcinoma and precancerous conditions (dysplasia ...
... cancer or precancerous conditions; immune suppression or dysregulation; rare inherited skin conditions; and genetic variants ...
Evaluation, biopsy, and treatment of cancerous or pre-cancerous skin conditions, like abnormal moles and lesions. ... Common conditions: tinnitus, vertigo, hearing loss, vestibular conditions, swallowing conditions We diagnose and treat ... Common conditions: arthritis, bunions, diabetic foot care, foot deformities, skin and nail conditions ... Common conditions: coronavirus, COVID-19 We offer COVID-19 vaccines to all Veterans enrolled in VA health care. This includes ...
Learn more about this pre-cancerous condition, sometimes referred to as "stage 0". We discuss the biology of DCIS, what it ... for a condition that may never cause illness or death. ...
This precancerous condition does not cause symptoms and often goes undiagnosed.. "But our findings show that obesity can now be ... "The diagnosis is usually by accident, often driven by tests performed for the diagnosis or management of other conditions," ... we hope that our results will encourage intervention strategies to prevent the progression of this condition to multiple ... defined as a risk factor for developing multiple myeloma through this condition," said the studys first author, Su-Hsin Chang ...
Cervical dysplasia (a precancerous condition in the cervix area).. *Endometriosis which is a condition in which the tissue ... Hysterectomy is the surgical removal of the uterus owing to any abnormal conditions. In some diseases, it becomes mandatory for ... is indicated in cases of cancerous lesions and ovaries or fallopian tubes is subjected to removal depending upon the condition. ...
She was diagnosed as having adenosis, a precancerous condition that required careful monitoring. In 1976, she had an abnormal ... As of 1972, plaintiff was aware, or at least suspected, that her condition was a result of her mothers ingestion of DES during ... Efforts were increased in 1976 and 1978 when plaintiffs condition became acute. Unfortunately, the doctor who [44 Cal. 3d 1108 ... have or may have contracted or in the future may contract adenocarcinoma or vaginal or cervical adenosis or precancerous tumors ...
  • The term precancerous or premalignant condition may refer to certain conditions, such as monoclonal gammopathy of unknown significance, or to certain lesions, such as colorectal adenoma (colon polyps), which have the potential to progress into cancer (see: Malignant transformation). (wikipedia.org)
  • Precancerous conditions of the skin or oral cavity can appear as visible lesions without associated pain or discomfort, while precancerous conditions of the hematological system are typically asymptomatic, and in the case of monoclonal gammopathy of unknown significance, it may only rarely cause numbness and tingling in the hands and feet or difficulty with balance (see: peripheral neuropathy). (wikipedia.org)
  • In most cases, many risk factors for precancerous conditions and lesions are the same risk factors that determines individuals vulnerable to a specific cancer. (wikipedia.org)
  • Hereditary conditions that are risk factors to cancer can also be risk factors to premalignant lesions. (wikipedia.org)
  • However, in many cases, precancerous conditions or lesions can be sporadic and idiopathic in nature, meaning that they are not associated with a hereditary genetic risk factor to the particular cancer, nor with a direct causative agent or other identifiable cause. (wikipedia.org)
  • The pathophysiology of precancerous lesions is thought to be similar to that of cancer, and also varies depending on the disease site and type of lesion. (wikipedia.org)
  • What are the precancerous lesions associated with HPV infection? (trustedtablets.online)
  • Lesions linked to HPV infection in the male reproductive system encompass conditions such as Bowen's ailment, Kaposi's erythroplasia, and squamous cell papules. (trustedtablets.online)
  • Are there low-risk HPV variants that lead to different precancerous lesions? (trustedtablets.online)
  • Yes, low-risk HPV variants, particularly types 6 and 11, are associated with precancerous lesions like giant pointed condylomas or Buschke-Lowenstein tumors. (trustedtablets.online)
  • These conditions have a different clinical presentation compared to high-risk HPV-related lesions. (trustedtablets.online)
  • What are the precancerous lesions not attributed to HPV? (trustedtablets.online)
  • Precancerous lesions not linked to HPV are predominantly associated with conditions like genital sclerotic and atrophic lichen and leukoplakia. (trustedtablets.online)
  • This approach can be used in treating certain precancerous lesions. (trustedtablets.online)
  • Is surgical excision a common treatment for all precancerous lesions? (trustedtablets.online)
  • Altered patterns of mucin secretion in the precancerous lesions induced in the glandular part of the rat stomach by the carcinogen N-methyl-N-nitrosoguanidine. (nih.gov)
  • This is indicated in cases of cancerous lesions and ovaries or fallopian tubes is subjected to removal depending upon the condition. (harcourthealth.com)
  • Update on epidemiology of gastrointestinal cancers and precancerous conditions/lesions. (eso.net)
  • Pathologically, precancerous tissue can range from benign neoplasias, which are tumors which don't invade neighboring normal tissues or spread to distant organs, to dysplasia, a collection of highly abnormal cells which, in some cases, has an increased risk of progressing to anaplasia and invasive cancer which is life-threatening. (wikipedia.org)
  • Precancerous conditions and epithelial dysplasia in the stomach. (nih.gov)
  • Dysplasia of the gastric mucosa and its relation to the precancerous state. (nih.gov)
  • The Canadian Task Force on Preventive Health Care recommends not screening adults with chronic gastroesophageal reflux disease (GERD) for esophageal adenocarcinoma and precursor conditions (Barrett esophagus or dysplasia), because there is an absence of evidence for benefit, and there are uncertain harms, important resource implications and variable patient values and preferences. (cmaj.ca)
  • Cervical dysplasia (a precancerous condition in the cervix area). (harcourthealth.com)
  • Pre-cancerous gynecologic conditions (hyperplasia and dysplasia, etc. (uwmedicine.org)
  • Dysplasia is a precancerous condition. (uchealth.org)
  • The Dysplasia Clinic, part of the Women's Gynaeoncology Service, provides specialist care for women with screen detected precancerous abnormalities of the cervix, vulva and vagina. (thewomens.org.au)
  • He performs this procedure to examine the specimen for any dysplasia, a precancerous condition, and grades it accordingly. (aapc.com)
  • Cervical cancer is preventable through the HPV vaccine, while regular screening for precancerous conditions can help early detection to reduce cases and deaths by allowing for timely treatment and effective management. (who.int)
  • Correlation of high risk Human Papilloma Virus and Chlamydia Trachomatis infection with cervical cancer and precancerous conditions. (who.int)
  • A precancerous condition is a condition, tumor or lesion involving abnormal cells which are associated with an increased risk of developing into cancer. (wikipedia.org)
  • Since Leukoplakia is a precancerous lesion, it is important to seek medical attention to have it biopsied and removed. (nutralegacy.com)
  • The actinic cheilitis is a lesion located at lower lip defined as a degenerative condition of the lining epithelium. (bvsalud.org)
  • If you have a history of this condition you should have regular medical checks of the previously treated areas and other areas that are susceptible to new cancers. (mydr.com.au)
  • This technique uses extreme cold to treat pre-cancerous skin conditions and some small skin cancers. (mydr.com.au)
  • Clinically, precancerous conditions encompass a variety of abnormal tissues with an increased risk of developing into cancer. (wikipedia.org)
  • Some of the most common precancerous conditions include certain colon polyps, which can progress into colon cancer, monoclonal gammopathy of undetermined significance, which can progress into multiple myeloma or myelodysplastic syndrome. (wikipedia.org)
  • Some authorities also refer to hereditary genetic conditions which predispose to developing cancer, such as hereditary nonpolyposis colorectal cancer, as a precancerous condition, as individuals with these conditions have a much higher risk of developing cancer in certain organs. (wikipedia.org)
  • In Lofty v Hamis t/a First Café , the EAT has set aside an employment tribunal's finding that a claimant with lentigo maligna - described as a 'pre-cancerous' condition by her consultant - did not fall within para 6 of Schedule 1 to the Equality Act 2010, which deems cancer to be a disability. (oldsquare.co.uk)
  • However, in the view of the tribunal, L's condition did not amount to cancer for the purposes of that provision: the consultant had referred to it as a 'pre-cancerous' condition and following L's operations it was confirmed that she had not developed skin cancer. (oldsquare.co.uk)
  • These conditions can lead to alterations in cellular composition without overt signs of cancer. (trustedtablets.online)
  • Nearly one in four women who receive a diagnosis of breast cancer will also develop this second condition. (qualityhealth.com)
  • It also can detect precancerous conditions, which can be treated to prevent cancer from occurring. (cdc.gov)
  • Some experts have suggested removing the "C" for carcinoma from DCIS because hearing "cancer" can prompt people to opt for aggressive treatment (and accompanying harms) for a condition that may never cause illness or death. (bcaction.org)
  • The test commonly checks for infection, inflammatory disease of the urinary tract, cancer, or precancerous conditions. (healthline.com)
  • In addition, we help patients avoid anal cancer by finding and managing precancerous conditions. (ucsfhealth.org)
  • Women who have been diagnosed with a high-grade precancerous condition of the cervix have a higher risk of developing vaginal cancer. (cancer.ca)
  • When the immune system is weakened, there is a greater chance that precancerous changes to cells in the vagina will develop into vaginal cancer. (cancer.ca)
  • Vaginal cancer possibly caused by pessary and immunocompromised condition: multiple risk factors may influence vaginal cancer development. (cancer.ca)
  • The disease is preventable, though, thanks to vaccines and effective treatments for conditions that can precede the cancer. (kalw.org)
  • It does mean that a woman needs to be vigilant about her health, though, and needs to be monitored for cancer, pre-cancerous conditions, and other problems that can be caused by HPV. (kalw.org)
  • These polyps sometimes change into cancer, so adenomas are considered a precancerous condition. (uchealth.org)
  • As more women have regular mammograms, doctors are detecting many noninvasive or precancerous conditions before they become cancer. (drugs.com)
  • Cancer is a diseased condition in which there is uncontrolled growth of a group of cells along with tendency of spreading or metastasis to other locations via lymph or blood. (hpathy.com)
  • Precancerous conditions - if there is any pre cancerous condition present it can lead to cancer. (hpathy.com)
  • But remember, endometrial hyperplasia is not cancer, it is a pre-cancerous condition which left untreated, can turn out to be cancerous. (cancer.org)
  • Endometrial hyperplasia is a pre-cancerous condition, which left untreated can turn into endometrial cancer. (cancer.org)
  • Lumps or specks can be from cancer, precancerous cells, or other conditions. (rockymountaincancercenters.com)
  • The researchers conducting the GISTAR study are investigating whether a combined strategy of testing for Helicobacter pylori infection and pepsinogen testing, followed by H. pylori eradication in positive subjects, and endoscopic follow-up of subjects with serological evidence of atrophic gastritis (a precancerous condition), reduces gastric cancer mortality compared with routine care. (who.int)
  • This is a pre-cancerous condition. (ecureme.com)
  • This is a pre-cancerous condition and high-grade Barrett's esophagus has a 30-40% risk of turning into invasive adenocarcinoma. (ecureme.com)
  • These terms describe when cells don't appear normal, but it can't be confirmed that they are cancerous or precancerous. (healthline.com)
  • and treat 90% of women who have pre-cancerous conditions. (kalw.org)
  • There is a pre- cancerous condition called endometrial hyperplasia, which has different stages. (cancer.org)
  • Barrett's disease is a relatively common pre-cancerous condition in patients with heartburn caused by the repeated exposure of the esophagus to acid refluxing from the stomach. (uams.edu)
  • Barrett's is concerning because it is a pre-cancerous condition," Tharian said. (uams.edu)
  • Leukoplakia can also be a precancerous condition. (webmd.com)
  • Most often, these premalignant conditions manifest clinically as leukoplakia and erythroplakia. (medscape.com)
  • HPV is linked to the development of precancerous conditions of the cervix. (cancer.ca)
  • Vaginal intraepithelial neoplasia (VAIN) is a precancerous condition of the vagina. (cancer.ca)
  • While vaginal itching is often associated with vaginitis or inflammation of the vagina, it can have other causes, ranging from a minor infection or allergic reaction to more serious conditions. (forbes.com)
  • Since vaginal itching can be caused by so many different conditions or infections, it can also go hand in hand with other uncomfortable symptoms. (forbes.com)
  • Hysterectomy is the surgical removal of the uterus owing to any abnormal conditions. (harcourthealth.com)
  • These polyps are more common, but in general, they are not precancerous. (uchealth.org)
  • A skin biopsy may occasionally be required to confirm the diagnosis, especially in rare cases where the condition doesn't respond to treatment. (healthline.com)
  • The diagnosis is usually by accident, often driven by tests performed for the diagnosis or management of other conditions," Chang said. (wustl.edu)
  • The signs and symptoms of precancerous conditions differ based on the organ affected. (wikipedia.org)
  • In many cases, individuals with precancerous conditions do not notice any symptoms. (wikipedia.org)
  • This precancerous condition does not cause symptoms and often goes undiagnosed. (wustl.edu)
  • Longstanding GERD has been linked to Barrett's esophagus, a precancerous condition. (nyp.org)
  • Precancerous conditions of the male reproductive organ are often linked to HPV infection. (trustedtablets.online)
  • Lymphomatoid granulomatosis is a rare precancerous condition triggered by Epstein-Barr virus infection. (cancer.gov)
  • Women with an abnormal cervical screening result that meet our updated acceptance criteria for colposcopy , and all women with post coital bleeding or a suspected precancerous condition, can be referred by a GP or specialist doctor. (thewomens.org.au)
  • Find out more about precancerous conditions of the vagina . (cancer.ca)
  • These conditions have their origin in chronic inflammatory processes, such as obliterating balanitis (xerotic obliterating balanitis). (trustedtablets.online)
  • Overall, rosacea is a common, chronic inflammatory skin condition. (healthline.com)
  • Besides HPV, other factors that can predispose individuals to the development of precancerous conditions include conditions like phimosis, engaging in promiscuous sexual liaisons, and suboptimal intimate hygiene practices. (trustedtablets.online)
  • Endometriosis which is a condition in which the tissue lining the uterus grows outside near the ovaries which leads to intense pain and bleeding during periods. (harcourthealth.com)
  • What are some common treatment options for precancerous states related to HPV? (trustedtablets.online)
  • Other less-common conditions that also demonstrate an increased risk for malignant transformation include oral submucous fibrosis (OSF), xeroderma pigmentosum , dyskeratosis congenita, epidermolysis bullosa , iron deficiency, and late-stage syphilis . (medscape.com)
  • This condition is significantly more common in men, especially between the ages of 50 to 70 years. (healthline.com)
  • This is one the most common precancerous conditions from constant sun exposure. (nutralegacy.com)
  • A thickened uterine lining is endometrial hyperplasia and its a precancerous condition. (cancer.org)
  • it is not sufficient that he or she might develop a relevant condition in the future. (oldsquare.co.uk)
  • Precancerous states within the male reproductive system are a complex set of conditions that often develop due to the presence of the human papillomavirus (HPV). (trustedtablets.online)
  • We are also active in research to develop more effective therapies for those conditions. (ucsfhealth.org)
  • The condition gradually develops after the onset of the initial stages of rosacea, which typically happen between the ages of 25 and 50. (healthline.com)
  • Although NHANES I provides a wealth of information on the prevalence of health conditions and risk factors, the cross-sectional nature of the original survey limits its usefulness in studying the effects of clinical, environmental, and behavioral factors and in tracing the natural history of disease. (cdc.gov)
  • PIN refers to the precancerous end of a morphologic spectrum involving cellular proliferation within prostatic ducts, ductules, and acini. (medscape.com)
  • The management of patients with precancerous conditions involves various approaches. (trustedtablets.online)
  • Based on our finding that being overweight or obese is a risk factor for multiple myeloma in MGUS patients, and since extra weight is a modifiable risk factor, we hope that our results will encourage intervention strategies to prevent the progression of this condition to multiple myeloma as soon as MGUS is diagnosed," Chang said. (wustl.edu)
  • As with other precancerous conditions, not all carcinoma in situ will become an invasive disease but is at risk of doing so. (wikipedia.org)
  • High-risk HPV strains, such as types 16 and 18, are often associated with these conditions. (trustedtablets.online)
  • But our findings show that obesity can now be defined as a risk factor for developing multiple myeloma through this condition," said the study's first author, Su-Hsin Chang, PhD, an assistant professor of surgery in the Division of Public Health Sciences at Washington University. (wustl.edu)
  • GI bleeding can be an emergency condition that requires immediate medical care. (medlineplus.gov)
  • We assess your situation and condition to decide which outpatient geriatric services are right for you or a senior Veteran in your care, and then we coordinate your care. (va.gov)
  • Terms and Conditions under which this service is provided to you. (ecureme.com)
  • The condition develops in the tissues of the anus, which is a short tube that connects the lower part of the large intestine, known as the rectum, to the outside of the body. (ucsfhealth.org)
  • GI bleeding may also be a sign of more serious diseases and conditions. (medlineplus.gov)
  • Earlier stages of rosacea can be confused with acne and other skin conditions. (healthline.com)
  • This painless condition occurs when the little bumps on your tongue grow long and trap bacteria that live in your mouth -- making the tongue look black and hairy. (webmd.com)
  • It is a significant contributor to the development of precancerous states in the male reproductive system. (trustedtablets.online)
  • This asymptomatic carrier state can still lead to the development of precancerous conditions. (trustedtablets.online)
  • Therefore, the NHANES I Epidemiologic Followup Study (NHEFS) was designed to investigate the association between factors measured at the baseline with the development of specific health conditions. (cdc.gov)