Predominant cortical dysfunction in Guadeloupean parkinsonism. (1/21)
(+info)Autonomic ganglia, acetylcholine receptor antibodies, and autoimmune ganglionopathy. (2/21)
(+info)Impaired baroreceptor reflex sensitivity in acute stroke is associated with insular involvement, but not with carotid atherosclerosis. (3/21)
(+info)Dysautonomia rating scales in Parkinson's disease: sialorrhea, dysphagia, and constipation--critique and recommendations by movement disorders task force on rating scales for Parkinson's disease. (4/21)
(+info)Ganglionic acetylcholine receptor autoantibody: oncological, neurological, and serological accompaniments. (5/21)
(+info)Peripherin-IgG association with neurologic and endocrine autoimmunity. (6/21)
(+info)A molecular sensor for the baroreceptor reflex? (7/21)
(+info)Dysautonomia due to reduced cholinergic neurotransmission causes cardiac remodeling and heart failure. (8/21)
(+info)'Primary Dysautonomias' are clinical disorders directly caused by genetically determined or inherited dysfunctions in the autonomic nervous system, which controls involuntary bodily functions such as heart rate, blood pressure, digestion, and body temperature.
Primary dysautonomias, also known as primary autonomic disorders or idiopathic dysautonomia, refer to a group of conditions that affect the autonomic nervous system (ANS) without an identifiable underlying cause. The ANS is responsible for regulating many automatic bodily functions such as heart rate, blood pressure, digestion, and body temperature.
In primary dysautonomias, the ANS fails to function properly, leading to a variety of symptoms that can affect different organ systems. These symptoms may include orthostatic intolerance (lightheadedness or fainting upon standing), irregular heart rate, excessive sweating, heat or cold intolerance, difficulty with digestion, and pupillary abnormalities.
Examples of primary dysautonomias include pure autonomic failure, multiple system atrophy, and familial dysautonomia. These conditions are typically progressive, meaning that symptoms tend to worsen over time. Treatment for primary dysautonomias is focused on managing symptoms and improving quality of life.
Primary autonomic failure
... (also called primary dysautonomia) refers to a category of dysautonomias - conditions in which the ... In primary dysautonomias, the autonomic dysfunction occurs as a primary condition (as opposed to resulting from another disease ... Such "primary" dysautonomias are distinguished from secondary dysautonomias, where the dysfunction of the autonomic nervous ... Many scientists also categorize Parkinson disease and familial dysautonomia as "primary". Noggle, Chad A.; Dean, Raymond S.; ...
Dysautonomia
... primary dysautonomia) or it may occur due to injury of the autonomic nervous system from an acquired disorder (secondary ... The prognosis of dysautonomia depends on several factors; individuals with chronic, progressive, generalized dysautonomia in ... Scholia has a profile for Dysautonomia (Dysautonomia). Brading A (1999). The autonomic nervous system and its effectors. Oxford ... The primary symptoms in individuals with dysautonomia include: Anhydrosis or hyperhidrosis Anxiety[better source needed] Blurry ...
Pure autonomic failure
... now grouped as primary autonomic disorders (also called primary dysautonomia), including Pure Autonomic Failure, Multiple ... Pure autonomic failure (PAF) is a form of dysautonomia that first occurs in middle age or later in life; diagnosed more often ... The primary differentiating characteristic of Pure autonomic failure is decreased circulation and synthesis of norepinephrine, ...
Orthostatic syncope
Neurally mediated causes include conditions that cause either primary or secondary failure of the autonomic system: Peripheral ... Acute dysautonomia (seen in a variant of Guillain-Barré syndrome) Toxin, drug or infection-induced neuropathy Non-neurally ... a definitive diagnosis may require a complete autonomic workup and coordination of care between the primary care provider, ...
Chromosome 9
Ehlers-Danlos syndrome familial dysautonomia Friedreich ataxia galactosemia Gorlin syndrome or nevoid basal cell carcinoma ... nonsyndromic deafness OCD polycythemia vera porphyria primary hyperoxaluria Tangier's disease tetrasomy 9p thrombotic ...
Hyperhidrosis
The cause of primary hyperhidrosis is unknown. Anxiety or excitement can exacerbate the condition. A common complaint of people ... dysreflexia Orthostatic hypotension Posttraumatic syringomyelia Associated with peripheral neuropathies Familial dysautonomia ( ... This use has been approved by the U.S. Food and Drug Administration (FDA). The duration of the beneficial effect in primary ... Primary or focal hyperhidrosis may be further divided by the area affected, for instance, palmoplantar hyperhidrosis ( ...
Neurological disorder
... the primary type of dysfunction involved, or the primary type of cause. The broadest division is between central nervous system ... system disorders Cranial nerve disorder such as Trigeminal neuralgia Autonomic nervous system disorders such as dysautonomia, ... Neurological disorders can be categorized according to the primary location affected, ...
Long COVID
Some people with long COVID experience dysautonomia, a malfunction of the central nervous system. People with dysautonomia may ... Greenhalgh T, Sivan M, Delaney B, Evans R, Milne R (September 2022). "Long covid-an update for primary care". BMJ. 378: e072117 ... Dysautonomia and postural orthostatic tachycardia syndrome (POTS) are also potential shared aspects of long COVID and ME/CFS. ... If people meet the diagnostic criteria for ME/CFS or for dysautonomia, it is possible that symptoms are lifelong. Estimates of ...
Electrochemical skin conductance
Assessment of dysautonomia is important for patient follow-up and assessment of sudomotor function can be helpful in daily ... The autonomic nervous system (ANS), of which sudomotor nerves are an integral part, is the primary extrinsic control mechanism ... ESC has clinical utility in the evaluation and follow-up of dysautonomia and small fiber peripheral neuropathy which may occur ... dysautonomia itself is an independent prognostic factor, and assessment of sweat disturbances is routine in the evaluation of ...
Parkinson's disease
non-primary source needed] Choi JG, Kim N, Ju IG, Eo H, Lim SM, Jang SE, et al. (January 2018). "Oral administration of Proteus ... January 2012). "Dysautonomia: perioperative implications". Anesthesiology. 116 (1): 205-215. doi:10.1097/ALN.0b013e31823db712. ... Assessment of sudomotor function through electrochemical skin conductance can be helpful in diagnosing dysautonomia. When PD ... closed). Strengthening exercises have shown improvements in strength and motor function for people with primary muscular ...
List of diseases (D)
Nonaka type Distal myopathy Distal primary acidosis, familial Distemper Distichiasis heart congenital anomalies Distomatosis ... thanatophoric Dwarfism thin bones multiple fractures Dyggve-Melchior-Clausen syndrome Dykes-Markes-Harper syndrome Dysautonomia ...
Mitral valve prolapse
It is the primary form of myxomatous degeneration of the valve. There are various types of MVP, broadly classified as classic ... Those with mitral valve prolapse and symptoms of dysautonomia (palpitations, chest pain) may benefit from beta-blockers (e.g., ... May 2019). "Primary cilia defects causing mitral valve prolapse". Science Translational Medicine. 11 (493). doi:10.1126/ ... May 2019). "Primary cilia defects causing mitral valve prolapse". Science Translational Medicine. 11 (493). doi:10.1126/ ...
Lorenz Studer
... the primary cell type affected in Parkinson's disease in vitro from dividing precursor cells. He successfully demonstrated that ... and using pluripotent stem cells as valuable tools for modeling human diseases such as Familial Dysautonomia, Hirschsprung's ...
Green ribbon
Dysautonomia, Interstitial Cystitis, Native American Reparation and Renal Cell Carcinoma Mixed ribbons: Anal Cancer (green & ... Primary Sclerosing Cholangitis, Pruned belly Syndrome, Von Hippel Lindau Gastroparesis Intellectual Disabilities Missing ...
Optic neuritis
The optic nerve comprises axons that emerge from the retina of the eye and carry visual information to the primary visual ... dysautonomia (i.e. autonomic nervous system dysfunction), and diabetes, or an injury to the eye. In neuromyelitis optica higher ...
Inappropriate sinus tachycardia
The mechanism and primary etiology of inappropriate sinus tachycardia has not been fully elucidated. An autoimmune mechanism ... Supraventricular tachycardia Sinus tachycardia Postural orthostatic tachycardia syndrome Dysautonomia Metabolic myopathies ...
Adrenergic storm
This enzyme is responsible for breaking down many compounds; basically, anything with a primary amine moiety is likely to be ... and dysautonomia present in the pre-coma stage of the disease. The behavioral symptoms are similar to those of an amphetamine, ...
Chiari malformation
"Dysautonomia News - Winter/Spring 2006". Dinet.org. Archived from the original on November 29, 2011. Retrieved November 4, 2011 ... Yu F, Jiang QJ, Sun XY, Zhang RW (June 2015). "A new case of complete primary cerebellar agenesis: clinical and imaging ... Maura Isles is diagnosed with the condition.[non-primary source needed] Rosanne Cash - U.S. singer-songwriter; daughter of ... Papilledema on fundoscopic exam due to Increased intracranial pressure Pupillary dilation Dysautonomia: tachycardia (rapid ...
Fibromyalgia
... non-primary source needed] increased pyruvate;[non-primary source needed] as well as reduced capillary density impairing oxygen ... An alternative hypothesis to nociplastic pain views fibromyalgia as a stress-related dysautonomia with neuropathic pain ... non-primary source needed] In patients with primary fibromyalgia, studies have found disruptions in energy metabolism within ... Primary fibromyalgia is idiopathic (cause unknown), whereas secondary fibromyalgia is in association with a known underlying ...
Orthostatic headache
Previously it was often misdiagnosed as different primary headache disorders such as migraine or tension headaches. Increasing ... Another cause of orthostatic headaches is postural orthostatic tachycardia syndrome (POTS), a form of dysautonomia, which is ...
Eating disorder
Rushing JM, Jones LE, Carney CP (October 2003). "Bulimia Nervosa: A Primary Care Review". Primary Care Companion to the Journal ... Dysautonomia can occur in conditions such as diabetes and alcoholism. Psychological disorders which may be confused with an ... Dysautonomia usually involves failure of sympathetic or parasympathetic components of the ANS system but may also include ... Ritchie, M Perdigao J,) Dysautonomia: a wide variety of autonomic nervous system (ANS) disorders may cause a wide variety of ...
Norepinephrine transporter
However, DAT, the primary way dopamine is transported out of the cell, can work to decrease dopamine concentration in the ... Orthostatic intolerance (OI) is a disorder of the autonomic nervous system (a subcategory of dysautonomia) characterized by the ... subsequently replaced tricyclics as the primary treatment option for depression because of their better tolerability and lower ...
List of diseases (M)
... primary autosomal recessive Microco Microcoria, congenital Microcornea correctopia macular hypoplasia Microcornea glaucoma ... Morse-Rawnsley-Sargent syndrome Motor neuron disease Motor neuro-ophthalmic disorders Motor neuropathy peripheral dysautonomia ...
Dementia with Lewy bodies
... and dysautonomia from the use of antipsychotics. Dysautonomia (autonomic dysfunction) occurs when Lewy pathology affects the ... They are most frequently due to primary neurodegenerative disease, resulting in the loss of dopaminergic nerve terminals along ... Thus, alpha-synuclein aggregation was established as the primary building block of the synucleinopathies. Between 1995 and 2005 ... Falls-caused by many factors including parkinsonism, dysautonomia, and frailness-increase morbidity and mortality. Failure to ...
Orthostatic hypotension
Primary orthostatic hypotension is also often referred to as neurogenic orthostatic hypotension. The drop in blood pressure may ... and other forms of dysautonomia. It is also associated with Ehlers-Danlos syndrome and anorexia nervosa. It is also present in ...
Ehlers-Danlos syndromes
"Ehlers-Danlos Syndrome". Underlying Causes of Dysautonomia. Dysautonomia International. 2012. Archived from the original on ... Group A disorders are those that affect primary collagen structure and processing. Group B disorders affect collagen folding ... Collagen primary structure and collagen processing: ADAMTS2, COL1A1, COL1A2, COL3A1, COL5A1, COL5A2 Collagen folding and ... Heart murmur Heart conduction abnormalities Hiatal hernia Gastroesophageal reflux Poor gastrointestinal motility Dysautonomia ...
List of neurological conditions and disorders
... spinal muscular atrophy type 2 Dizziness Down syndrome Dravet syndrome Duchenne muscular dystrophy Dysarthria Dysautonomia ... Posttraumatic stress disorder Postural hypotension Postural orthostatic tachycardia syndrome Prader-Willi syndrome Primary ...
PHOX2B
Mutations in human PHOX2B cause a rare disease of the visceral nervous system (dysautonomia): congenital central ... "Diagnostic Utility of PHOX2B in Primary and Treated Neuroblastoma and in Neuroblastoma Metastatic to the Bone Marrow". Archives ...
List of MeSH codes (C10)
... primary MeSH C10.228.140.546.399.750 - migraine disorders MeSH C10.228.140.546.399.750.250 - migraine with aura MeSH C10.228. ... dysautonomia, familial MeSH C10.574.500.497 - huntington disease MeSH C10.574.500.529 - lafora disease MeSH C10.574.500.536 - ... primary progressive aphasia MeSH C10.228.140.380.165 - creutzfeldt-jakob syndrome MeSH C10.228.140.380.230 - dementia, vascular ... primary progressive aphasia MeSH C10.597.606.150.500.800.100.166 - receptive aphasia MeSH C10.597.606.150.500.800.150 - ...
Lesch-Nyhan syndrome
Of these, only individuals with Lesch-Nyhan syndrome, de Lange syndrome, and familial dysautonomia recurrently display loss of ... non-primary source needed] However, some evidence suggests against a role for uric acid in the neuropathology of Lesch-Nyhan ... familial dysautonomia, choreoacanthocytosis, sensory neuropathy including hereditary sensory neuropathy type 1, and several ... syndrome: Hyperuricemia associated with classic primary gout, which is caused by low uric acid renal clearance rather than uric ...
Dysautonomia: Treatment and more
While there is no cure for dysautonomia, treatment can help people manage many of the symptoms. Learn more here. ... Primary dysautonomia. Treatment for primary dysautonomia focuses mainly on managing symptoms. Postural orthostatic tachycardia ... Dysautonomia can occur alone (primary dysautonomia) or result from another condition (secondary dysautonomia). ... Some forms of secondary dysautonomia can improve with treatment. Primary dysautonomia is not curable, but some of the symptoms ...
Dysautonomia | National Institute of Neurological Disorders and Stroke
Dysautonomia usually involves failure of the sympathetic and parasympathetic parts of the ANS. ... Dysautonomia is a disorder of autonomic nervous system (ANS) function. The ANS is in charge of involuntary functions, or things ... Several common conditions such as diabetes and alcoholism can include dysautonomia. Dysautonomia also can occur as a primary or ... Familial Dysautonomia Foundation. Phone: 212-279-1066. Familial Dysautonomia Hope Foundation, Inc. (FD Hope). Phone: 919-969- ...
Tilt-Table Testing Technique: Approach Considerations, Tilt-Table Testing, Test Results
Familial dysautonomia - Getting a Diagnosis - Genetic and Rare Diseases Information Center
Learn about diagnosis and specialist referrals for Familial dysautonomia. ... Find a primary care provider in your area using Care Compare Doctors & clinicians by typing in your zip code and selecting " ... The primary care provider (PCP) is usually the center of the team. Your health care providers may refer you to other ... Because Familial dysautonomia is considered a genetic disease, you may want to ask your health care team if genetic testing is ...
Autonomic Neuropathy Treatment & Management: Medical Care, Treatments for Specific Conditions, Surgical Care
Dysautonomia. Management of dysautonomia in cases of GBS is difficult. [39, 40] Primary therapy of the condition consists of ... Plasma exchange for primary autoimmune autonomic failure. N Engl J Med. 2005 Oct 13. 353(15):1585-90. [QxMD MEDLINE Link]. ... AL (immunoglobulin light chain, historically known as primary) amyloidosis is the most common type of systemic amyloidosis. AL ... Peripheral neuropathy associated with primary Sjögrens syndrome. J Neurol Neurosurg Psychiatry. 1994 Aug. 57(8):983-6. [QxMD ...
Cyanosis With Dysautonomia Mimics Raynaud Disease - PubMed
Primary Dysautonomias* Actions. * Search in PubMed * Search in MeSH * Add to Search ... Cyanosis With Dysautonomia Mimics Raynaud Disease Alyxandra Morgan Soloway 1 , Nicholas L DePace 2 , Joseph Colombo 3 , Stephen ... Cyanosis With Dysautonomia Mimics Raynaud Disease Alyxandra Morgan Soloway et al. J Clin Rheumatol. 2020 Oct. ... Dysautonomia and its underlying mechanisms in the hypermobility type of Ehlers-Danlos syndrome. Semin Arthritis Rheum. 2014;44: ...
Dysautonomia | Autonomic Nervous System Disorders | MedlinePlus
Dysautonomia is a disorder of the autonomic nervous system, which controls functions such as breathing and heartbeat. Read more ... The primary NIH organization for research on Autonomic Nervous System Disorders is the National Institute of Neurological ... Familial dysautonomia: MedlinePlus Genetics (National Library of Medicine) * Horner syndrome: MedlinePlus Genetics (National ... Dysautonomia (National Institute of Neurological Disorders and Stroke) * Orthostatic Hypotension (National Institute of ...
Primary autonomic failure - Wikipedia
Primary autonomic failure (also called primary dysautonomia) refers to a category of dysautonomias - conditions in which the ... In primary dysautonomias, the autonomic dysfunction occurs as a primary condition (as opposed to resulting from another disease ... Such "primary" dysautonomias are distinguished from secondary dysautonomias, where the dysfunction of the autonomic nervous ... Many scientists also categorize Parkinson disease and familial dysautonomia as "primary". Noggle, Chad A.; Dean, Raymond S.; ...
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Dysautonomia and chronic fatigue syndrome (CFS/CFIDS) are often used interchangeably. Studies have shown that over 90% of CFS ... "Cognitive problems may be a primary symptom of CFS, particularly in children. Affected ... Some of the ADD/ADHD meds are also used for dysautonomia- coincidence? I think not My son began taking concerta for fatigue/ ... And, YES, there is enormous overlap between the ADD/ADHD phenomenon & dysautonomia, BUT it is hard to find in the medical ...
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Determining the Cause(s) of Dysautonomia, Vagopathy, and Autonomic Nervous System Imbalances - Caring Medical Florida
The primary reason patients are seen at our Neck Center is to receive Comprehensive Prolotherapy and curve correction in order ... Determining the Cause(s) of Dysautonomia, Vagopathy, and Autonomic Nervous System Imbalances. The dynamic ANS testing at The ... The major causes of dysautonomia, vagopathy and autonomic nervous system imbalances can be broken down into two camps: ... Determining the Cause(s) of Dysautonomia, Vagopathy, and Autonomic Nervous System Imbalances ...
I Got Fired As A Patient - Dysautonomia Discussion - Dysautonomia Information Network (DINET)
ive waited to share this but here goes: My doc of about 10 years was not only my primary care doc, but also my friend as well ... I suggest you look for a good specialist even its a 90 minute drive (make sure they see a lot of Dysautonomia people). ... I am convinced that finding the CAUSE of POTS/Dysautonomia is the first step in successful treatment, and no one has bothered ...
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RFA-HD-14-033: Centers for Collaborative Research in Fragile X (U54)
Fragile X-associated Primary Ovarian Insufficiency (FXPOI). Women with the Fragile X premutation are at risk for primary ... Associated clinical features include peripheral neuropathy, dysautonomia, and particularly in women with FXTAS, hypothyroidism ... Fragile X Associated Primary Ovarian Insufficiency. *Develop model systems in which expanded FMR1 CGG repeats induce the ... Fragile X Associated Primary Ovarian Insufficiency. * Elucidate associations between CGG repeat structure across the entire ...
Salt - New World Encyclopedia
Dysautonomia. Cleveland Clinic Health Information Center. *↑ Salt and other wounds. Why Files article. Retrieved July 30, 2007. ... Sodium is one of the primary electrolytes in the body. All three electrolytes (sodium, potassium, and calcium) are available in ... Salt is even sometimes used as a health aid, such as in treatment of dysautonomia.[20] ...
Dysautonomia, Familial | Profiles RNS
Primary Dysautonomias [C10.177.575]. *Dysautonomia, Familial [C10.177.575.300]. *Nervous System Malformations [C10.500] ... "Dysautonomia, Familial" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are MeSH descriptors whose meaning is related to "Dysautonomia, Familial".. *Hereditary Sensory and Autonomic ... This graph shows the total number of publications written about "Dysautonomia, Familial" by people in this website by year, and ...
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MeSH Browser
Primary Dysautonomias Preferred Term Term UI T701669. Date07/12/2007. LexicalTag NON. ThesaurusID NLM (2009). ... Primary Dysautonomias Preferred Concept UI. M0002015. Scope Note. Disorders of the AUTONOMIC NERVOUS SYSTEM occurring as a ... Primary Dysautonomias. Tree Number(s). C10.177.575. Unique ID. D054969. RDF Unique Identifier. http://id.nlm.nih.gov/mesh/ ... 2009; for DYSAUTONOMIA use AUTONOMIC NERVOUS SYSTEM DISEASES 1989-2008. Date Established. 2009/01/01. Date of Entry. 2008/07/08 ...
MeSH Browser
Primary Dysautonomias Preferred Term Term UI T701669. Date07/12/2007. LexicalTag NON. ThesaurusID NLM (2009). ... Primary Dysautonomias Preferred Concept UI. M0002015. Scope Note. Disorders of the AUTONOMIC NERVOUS SYSTEM occurring as a ... Dysautonomia Previous Indexing. Autonomic Nervous System Diseases (1963-2008). Public MeSH Note. 2009; for DYSAUTONOMIA see ... Primary Dysautonomias. Tree Number(s). C10.177.575. Unique ID. D054969. RDF Unique Identifier. http://id.nlm.nih.gov/mesh/ ...
The RCCX theory of chronic illness | Integrative Practitioner
DeCS
PRIMARY DYSAUTONOMIAS is also available. Allowable Qualifiers:. BL blood. CF cerebrospinal fluid. CI chemically induced. CL ... Dysautonomia, Familial Entry term(s). Dominant Hereditary Sensory Neuropathy, Type III Familial Dysautonomia HSAN (Hereditary ... Dysautonomia, Familial - Preferred Concept UI. M0006912. Scope note. An autosomal disorder of the peripheral and autonomic ... Familial Dysautonomia. HSAN (Hereditary Sensory and Autonomic Neuropathy) Type III. HSAN 3. HSAN III. HSAN Type III. HSAN3. HSN ...
Neurologic and Psychiatric Effects of SARS-CoV-2 Meeting: Day 1 - National Institute of Mental Health (NIMH)
So we know that when we put it in the mouse nose in the trans gene it hops on the neurons and it goes into the primary and ... So we are putting together a cohort of individuals where we primarily want to study dysautonomia, and the few that weve ... encephalomyelitis are really associated with primary inflammatory disorders, primary immune-related disorders, and it is ... Now one has to be a little bit careful because you can also get myocarditis and you can get AV blocks, primary and secondary AV ...
Sekar, Anisha 2023 - Office of NIH History and Stetten Museum
Subset Code Subset Name Concept Code NCI Preferred Term NCIT Definition ACC/AHA Preferred Term ACC/AHA Synonyms(s) ACC/AHA...
Familial dysautonomia (Riley- Day, hereditary sensory and autonomic neuropathy type III) A dysautonomia due to a genetic ... It can be primary, the result of central nervous system degeneration, or secondary due to diabetes or alcoholism. Patients with ... Dysautonomia A condition in which there is a severe imbalance in the autonomic nervous system. C167409 ACC/AHA Pediatric and ... Chief Complaint The primary reason for a patient visit to a healthcare provider. C167409 ACC/AHA Pediatric and Congenital ...
What is Dysautonomia? - Dysautonomia Support Network
Dysautonomia [dis-aw-tuh-noh-mee-uh] Also called autonomic dysfunction, is an umbrella term used to describe disorders that ... Some dysautonomias are rare, while others are much more common. Dysautonomia can occur alone, known as a primary condition, or ... 2020). Dysautonomia. {1, 4, 6}. Freeman, K., Goldstein, D.S., & Thompson, C.R. (2015). The dysautonomia project: Understanding ... 2019). Dysautonomia Information Page. National Institutes of Health. {11}. Shaw, B. H., Stiles, L. E., Bourne, K., Green, E. A ...
Early Estimate of Nirsevimab Effectiveness for Prevention of Respiratory Syncytial Virus-Associated Hospitalization Among...
Primary care provider record verification was performed in sites without mandatory reporting of nirsevimab administration to ... instability or dysautonomia, agenesis or hypoplasia of the corpus callosum, muscular dystrophy or spinal muscular atrophy, ... instability or dysautonomia, agenesis or hypoplasia of the corpus callosum, muscular dystrophy or spinal muscular atrophy, ... primary, or secondary], or interstitial lung disease) (12); hemodynamically significant congenital heart disease (abnormalities ...