Primate Diseases
Primates
Macaca mulatta
Macaca fascicularis
Papio
A genus of the subfamily CERCOPITHECINAE, family CERCOPITHECIDAE, consisting of five named species: PAPIO URSINUS (chacma baboon), PAPIO CYNOCEPHALUS (yellow baboon), PAPIO PAPIO (western baboon), PAPIO ANUBIS (or olive baboon), and PAPIO HAMADRYAS (hamadryas baboon). Members of the Papio genus inhabit open woodland, savannahs, grassland, and rocky hill country. Some authors consider MANDRILLUS a subgenus of Papio.
Callithrix
Macaca
Lentiviruses, Primate
Strepsirhini
Opportunistic Pneumocystis carinii infection in red-bellied tamarins (Saguinus labiatus). (1/168)
P. carinii infection in red-bellied tamarins (Saguinus labiatus), born and maintained in a laboratory breeding colony, was examined by histopathologic examination postmortem. P. carinii cysts were detected in 6 of 10 red-bellied tamarins examined, by using Grocott's, toluidine blue O and immunostaining with avidin-biotin complex using antisera for rat-, simian-, and human-P. carinii. The results obtained from the present studies imply that P. carinii may be an important pathogen in this species. (+info)Natural and experimental oral infection of nonhuman primates by bovine spongiform encephalopathy agents. (2/168)
Experimental lemurs either were infected orally with the agent of bovine spongiform encephalopathy (BSE) or were maintained as uninfected control animals. Immunohistochemical examination for proteinase-resistant protein (prion protein or PrP) was performed on tissues from two infected but still asymptomatic lemurs, killed 5 months after infection, and from three uninfected control lemurs. Control tissues showed no staining, whereas PrP was detected in the infected animals in tonsil, gastrointestinal tract and associated lymphatic tissues, and spleen. In addition, PrP was detected in ventral and dorsal roots of the cervical spinal cord, and within the spinal cord PrP could be traced in nerve tracts as far as the cerebral cortex. Similar patterns of PrP immunoreactivity were seen in two symptomatic and 18 apparently healthy lemurs in three different French primate centers, all of which had been fed diets supplemented with a beef protein product manufactured by a British company that has since ceased to include beef in its veterinary nutritional products. This study of BSE-infected lemurs early in their incubation period extends previous pathogenesis studies of the distribution of infectivity and PrP in natural and experimental scrapie. The similarity of neuropathology and PrP immunostaining patterns in experimentally infected animals to those observed in both symptomatic and asymptomatic animals in primate centers suggests that BSE contamination of zoo animals may have been more widespread than is generally appreciated. (+info)A novel Epstein-Barr virus-like virus, HV(MNE), in a Macaca nemestrina with mycosis fungoides. (3/168)
Epstein-Barr virus (EBV) infection of humans has been associated with the development of lymphoid malignancies mainly of B-cell lineage, although occasionally T-cell lymphomas have been reported. We describe here the characterization of a novel EBV-like virus (HV(MNE)) isolated from a simian T-cell lymphotropic virus type I/II (STLV-I/II) seronegative pigtailed macaque (Macaca nemestrina) with a cutaneous T-cell lymphoma. Immunohistochemistry studies on the skin lesions demonstrated that the infiltrating cells were of the CD3(+)/CD8(+) phenotype. Two primary transformed CD8(+) T-cell lines were obtained from cultures of peripheral blood mononuclear cells (PBMC) and skin, and, with time, both cell lines became interleukin-2-independent and acquired the constitutive activation of STAT proteins. Polymerase chain reaction analysis of the DNA from the cell lines and tissues from the lymphomatous animal demonstrated the presence of a 536-bp DNA fragment that was 90% identical to EBV polymerase gene sequences, whereas the same DNA was consistently negative for STLV-I/II sequences. Electron microscopy performed on both cell lines, after sodium butyrate treatment, showed the presence of a herpes-like virus that was designated HV(MNE) according to the existing nomenclature. In situ hybridization studies using EBV Epstein-Barr viral-encoded RNA probes showed viral RNA expression in both CD8(+) T-cell lines as well as in the infiltrating CD8(+) T cells of skin-tissue biopsies. Phylogenetic analysis of a 465-bp fragment from the polymerase gene of HV(MNE) placed this virus within the Lymphocryptovirus genus and demonstrated that HV(MNE) is a distinct virus, clearly related to human EBV and other EBV-like herpesviruses found in nonhuman primates. (+info)Species-specific TT viruses and cross-species infection in nonhuman primates. (4/168)
Viruses resembling human TT virus (TTV) were searched for in sera from nonhuman primates by PCR with primers deduced from well-conserved areas in the untranslated region. TTV DNA was detected in 102 (98%) of 104 chimpanzees, 9 (90%) of 10 Japanese macaques, 4 (100%) of 4 red-bellied tamarins, 5 (83%) of 6 cotton-top tamarins, and 5 (100%) of 5 douroucoulis tested. Analysis of the amplification products of 90 to 106 nucleotides revealed TTV DNA sequences specific for each species, with a decreasing similarity to human TTV in the order of chimpanzee, Japanese macaque, and tamarin/douroucouli TTVs. Full-length viral sequences were amplified by PCR with inverted nested primers deduced from the untranslated region of TTV DNA from each species. All animal TTVs were found to be circular with a genomic length at 3.5 to 3.8 kb, which was comparable to or slightly shorter than human TTV. Sequences closely similar to human TTV were determined by PCR with primers deduced from a coding region (N22 region) and were detected in 49 (47%) of the 104 chimpanzees; they were not found in any animals of the other species. Sequence analysis of the N22 region (222 to 225 nucleotides) of chimpanzee TTV DNAs disclosed four genetic groups that differed by 36.1 to 50.2% from one another; they were 35.0 to 52.8% divergent from any of the 16 genotypes of human TTV. Of the 104 chimpanzees, only 1 was viremic with human TTV of genotype 1a. It was among the 53 chimpanzees which had been used in transmission experiments with human hepatitis viruses. Antibody to TTV of genotype 1a was detected significantly more frequently in the chimpanzees that had been used in transmission experiments than in those that had not (8 of 28 [29%] and 3 of 35 [9%], respectively; P = 0.038). These results indicate that species-specific TTVs are prevalent in nonhuman primates and that human TTV can cross-infect chimpanzees. (+info)TT virus infection in nonhuman primates and characterization of the viral genome: identification of simian TT virus isolates. (5/168)
Newly discovered TT virus (TTV) is widely distributed in human populations. To understand more about the relationship between TTV and its hosts, we tested 400 sera from various nonhuman primates for the presence of TTV DNA by PCR assay. We collected serum samples from 24 different species of nonhuman primates. TTV DNA was determined by PCR with primers designed from the 5'-end region of the TTV genome. Nucleotide sequencing and phylogenetic analysis of viral genomes were also performed. TTV DNA was detected in 87 of 98 (89%) chimpanzees and 3 of 21 (14%) crab-eating macaques. Nucleotide sequences of the PCR products obtained from both animals were 80 to 100% identical between two species. In contrast, the sequences differed from TTV isolates in humans by 24 to 33% at the nucleotide level and 36 to 50% at the amino acid level. Phylogenetic analysis demonstrated that all TTV isolates obtained from simians were distinct from the human TTV isolates. Furthermore, TTV in simians, but not in humans, was classified into three different genotypes. Our results indicate that TTV in simians represents a group different from, but closely related to, TTV in humans. From these results, we tentatively named this TTV simian TTV (s-TTV). The existence of the s-TTV will be important in determining the origin, nature, and transmission of human TTV and may provide useful animal models for studies of the infection and pathogenesis of this new DNA virus. (+info)Detection of hepatitis B virus infection in wild-born chimpanzees (Pan troglodytes verus): phylogenetic relationships with human and other primate genotypes. (6/168)
Infection with hepatitis B virus (HBV) was detected by serological testing for HBV surface antigen and by PCR assay for HBV DNA in serum samples from two common chimpanzees (Pan troglodytes subsp. verus) born in West Africa. The complete genome sequences obtained by nucleotide sequencing of overlapping DNA fragments amplified by PCR were compared with HBV variants recovered from other primates and with human genotypes A to F. Both chimpanzee sequences were 3, 182 nucleotides in length, and the surface gene sequence predicted the existence of a, d, and w serological determinants. Neither sequence contained stop codons in the precore region. On phylogenetic analysis, the HBV variants infecting the chimpanzees clustered together with a third chimpanzee HBV isolate independently obtained from an infected captive animal (A. J. Zuckerman, A. Thornton, C. R. Howard, K. N. Tsiquaye, D. M. Jones, and M. R. Brambell, Lancet ii:652-654, 1978), with an overall sequence similarity of >94%. This provides strong evidence for a chimpanzee-specific genotype of HBV which circulates in nature. These findings add to the recent evidence for infection in the wild of other Old and New World primates (gibbon, orangutan, and woolly monkey) with species-specific variants of HBV. There is no evidence for close phylogenetic clustering of variants found so far in primates with any of the established HBV genotypes from humans. With the new evidence for the widespread distribution of HBV in primates, hypotheses for the origins of human infection are reviewed. (+info)A novel type D simian retrovirus naturally infecting the Indian Hanuman langur (Semnopithecus entellus). (7/168)
As a simian species, the langurs are not known to harbor simian retroviruses, except for one report on a simian Type D endogenous retrovirus from the spectacled langur (Trachypithecus obscurus) from Malaysia. The present report describes for the first time natural infection of the common Hanuman langur (Semnopithecus entellus) from India by a novel simian retrovirus (SRV). The new SRV is phylogenetically related to but distinct from the three molecularly characterized serotypes, SRV 1-3, of the five known serotypes of SRVs, based on sequence analyses from the 3'orf and env regions of the viral genome. The novel SRV isolated from the Indian Hanuman langur is provisionally named SRV-6. (+info)Promiscuity and the primate immune system. (8/168)
The behavioral and ecological factors involved in immune system evolution remain poorly explored. We present a phylogenetic analysis of white blood cell counts in primates to test three hypotheses related to disease risk: increases in risk are expected with group size or population density, exposure to soil-borne pathogens, and mating promiscuity. White blood cell counts were significantly greater in species where females have more mating partners, indicating that the risk of sexually transmitted disease is likely to be a major factor leading to systematic differences in the primate immune system. (+info)'Primate diseases' refer to infectious illnesses that primarily affect non-human primates, including but not limited to monkeys, apes, and prosimians, and can potentially pose zoonotic risks to humans through close contact.
Primatology is the study of primates, which includes humans and non-human primates such as monkeys, apes, and lemurs. Primate diseases refer to the range of infectious and non-infectious health conditions that affect these animals. These diseases can be caused by various factors including bacteria, viruses, parasites, fungi, genetics, environmental conditions, and human activities such as habitat destruction, hunting, and keeping primates as pets.
Examples of primate diseases include:
1. Retroviral infections: Primates are susceptible to retroviruses, including simian immunodeficiency virus (SIV) which is the precursor to human immunodeficiency virus (HIV).
2. Herpesviruses: Many primate species are infected with herpesviruses that can cause a range of diseases from mild skin infections to severe neurological disorders.
3. Tuberculosis: Primates can contract tuberculosis, which is caused by the bacterium Mycobacterium tuberculosis and can affect multiple organs.
4. Malaria: Primates are hosts to various species of Plasmodium parasites that cause malaria.
5. Hepatitis: Primates can be infected with hepatitis viruses, including hepatitis B and C.
6. Respiratory infections: Primates can suffer from respiratory infections caused by bacteria, viruses, or fungi.
7. Gastrointestinal diseases: Primates can develop gastrointestinal disorders due to bacterial, viral, or parasitic infections.
8. Neurological disorders: Primates can suffer from neurological conditions such as encephalitis and meningitis caused by various pathogens.
9. Reproductive diseases: Primates can experience reproductive health issues due to infectious agents or environmental factors.
10. Cancer: Primates, like humans, can develop cancer, which can be caused by genetic predisposition, viral infections, or environmental factors.
Understanding primate diseases is crucial for the conservation of endangered species, managing zoonotic diseases that can spread from animals to humans, and advancing medical research, particularly in the fields of infectious diseases and cancer.
'Primates' is a taxonomic order comprising various species of mammals, including humans, apes, monkeys, and others, distinguished by distinct anatomical and behavioral characteristics such as forward-facing eyes, grasping hands, and complex social structures.
In a medical or scientific context, "Primates" is a biological order that includes various species of mammals, such as humans, apes, monkeys, and prosimians (like lemurs and lorises). This group is characterized by several distinct features, including:
1. A forward-facing eye position, which provides stereoscopic vision and depth perception.
2. Nails instead of claws on most digits, except for the big toe in some species.
3. A rotating shoulder joint that allows for a wide range of motion in the arms.
4. A complex brain with a well-developed cortex, which is associated with higher cognitive functions like problem-solving and learning.
5. Social structures and behaviors, such as living in groups and exhibiting various forms of communication.
Understanding primates is essential for medical and biological research since many human traits, diseases, and behaviors have their origins within this group.
'Macaca mulatta', also known as the rhesus macaque, is a species of Old World monkey that is widely distributed in central, eastern, and southern parts of Asia, and is extensively used as a model organism in medical research due to its close genetic relationship with humans.
"Macaca mulatta" is the scientific name for the Rhesus macaque, a species of monkey that is native to South, Central, and Southeast Asia. They are often used in biomedical research due to their genetic similarity to humans.
'Macaca fascicularis', also known as the crab-eating macaque or long-tailed macaque, is a species of Old World monkey that originates from Southeast Asia, recognized by its grayish or brownish fur, long tail, and habitats ranging from forests to grasslands.
"Macaca fascicularis" is the scientific name for the crab-eating macaque, also known as the long-tailed macaque. It's a species of monkey that is native to Southeast Asia. They are called "crab-eating" macaques because they are known to eat crabs and other crustaceans. These monkeys are omnivorous and their diet also includes fruits, seeds, insects, and occasionally smaller vertebrates.
Crab-eating macaques are highly adaptable and can be found in a wide range of habitats, including forests, grasslands, and wetlands. They are also known to live in close proximity to human settlements and are often considered pests due to their tendency to raid crops and steal food from humans.
These monkeys are social animals and live in large groups called troops. They have a complex social structure with a clear hierarchy and dominant males. Crab-eating macaques are also known for their intelligence and problem-solving abilities.
In medical research, crab-eating macaques are often used as animal models due to their close genetic relationship to humans. They are used in studies related to infectious diseases, neuroscience, and reproductive biology, among others.
"Papio" is a genus of Old World monkeys, commonly known as baboons, which are large, ground-dwelling primates with robust bodies, dog-like faces, and distinctive manes, native to the savannas and woodlands of Africa.
"Papio" is a term used in the field of primatology, specifically for a genus of Old World monkeys known as baboons. It's not typically used in human or medical contexts. Baboons are large monkeys with robust bodies and distinctive dog-like faces. They are native to various parts of Africa and are known for their complex social structures and behaviors.
Callithrix is a genus of New World monkeys, commonly known as marmosets and tamarins, characterized by their small size, tactile grooming claws, and unique reproductive strategies including twin pregnancies and paternal care. (27 words)
Callithrix is a genus of New World monkeys, also known as marmosets. They are small, active primates found in the forests of South and Central America. The term "Callithrix" itself is derived from the Greek words "kallis" meaning beautiful and "thrix" meaning hair, referring to their thick, vibrantly colored fur.
Marmosets in the genus Callithrix are characterized by their slender bodies, long, bushy tails, and specialized dental structures that allow them to gouge tree bark to extract sap and exudates, which form a significant part of their diet. They also consume fruits, insects, and small vertebrates.
Some well-known species in this genus include the common marmoset (Callithrix jacchus), the white-headed marmoset (Callithrix geoffroyi), and the buffy-tufted-ear marmoset (Callithrix aurita). Marmosets are popular subjects of research due to their small size, short gestation period, and ease of breeding in captivity.
'Macaca' is a genus of Old World monkeys, primarily found in Asia, characterized by their adaptability to various environments and known for including several species with significant research value in biomedical studies, such as rhesus macaques and crab-eating macaques.
I'm sorry for any confusion, but "Macaca" is not a medical term. It is the name of a genus that includes several species of monkeys, commonly known as macaques. These primates are often used in biomedical research due to their similarities with humans in terms of genetics and physiology. If you have any questions related to medicine or health, I would be happy to try to help answer them.
Lentiviruses, primate, refer to a genus of viruses within the Retroviridae family that primarily infect simian species, characterized by their ability to cause persistent infection and slowly progressive diseases, often associated with immune system dysfunction, and known for their potential use in gene therapy due to their capacity to integrate into host genome and long-term expression of transferred genes.
Lentiviruses are a genus of retroviruses that cause chronic diseases with long incubation periods. Primate lentiviruses specifically refer to those that primarily infect primates, including humans. There are four main types of primate lentiviruses: human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2), simian immunodeficiency virus (SIV), and puma (or lion) lentivirus (PLV).
HIV-1 is the primary cause of acquired immunodeficiency syndrome (AIDS) in humans, while HIV-2 is less virulent and prevalent. SIV infects various species of non-human primates, causing an AIDS-like disease. PLV infects wild pumas and domestic cats, causing a slow, progressive immune deficiency.
Primate lentiviruses have complex life cycles involving both DNA and RNA stages. They can integrate their genetic material into the host cell's genome, leading to persistent infection and potential oncogenic effects. These viruses primarily target cells of the immune system, such as CD4+ T-cells and macrophages, ultimately leading to immunodeficiency and increased susceptibility to opportunistic infections.
Strepsirhini is a biological classification that includes all strepsirrhine primates, characterized by their wet noses, grooming claws, and a grooming pad on the underside of their hands, as well as a toothcomb, which is a group of specialized incisors in the lower jaw used for personal grooming.
Strepsirhini is a term used in primatology and physical anthropology to refer to a parvorder of primates that includes lemurs, lorises, and galagos (bushbabies). This group is characterized by several features, including a wet nose, a grooming claw on the second digit of the hind foot, and a toothcomb - a set of lower incisors and canines specialized for grooming.
The term Strepsirhini comes from the Greek words "streptos" meaning twisted and "rhinos" meaning nose, referring to the wet, rhinarium (naked, moist snout) found in these primates. This is one of the two major divisions within the infraorder Lemuriformes, the other being Haplorhini, which includes tarsiers, monkeys, apes, and humans.
Cercopithecidae, also known as Old World monkeys, is a family of primates characterized by a tail that is often long and lacks a cartilaginous tip, and includes species such as baboons, macaques, colobus monkeys, and langurs, which are native to Africa and Asia.
Cercopithecidae is a family of Old World primates, which includes monkeys such as baboons, macaques, and langurs. These primates are characterized by their adaptations for arboreal or terrestrial living, and they have complex social structures. The family Cercopithecidae is divided into two subfamilies: Cercopithecinae (guenons, macaques, and langurs) and Colobinae (leaf monkeys and colobus monkeys). These primates are found in Africa and Asia, and they play important ecological roles in their environments.
Human-to-primate transmission
Epidemiology, Parasitology, Infectious diseases, Public health, Serology, Zoonoses). ... Human-to-primate transmission (HPT) is a seldom-remarked epidemiologic vector. It is by definition a cross-species transmission ... Microbiology and Infectious Diseases. 58: 1-10. doi:10.1016/j.cimid.2018.06.007. PMID 30245044. S2CID 52335531. ( ...
Primate basal ganglia
Also, several major degenerative diseases of the basal ganglia, including Parkinson's disease and Huntington's disease, are ... The cholinergic interneurons of the primate, are very different from those of non-primates. These are said to be tonically ... In upper primates it has three parts instead of two, with their own types of neuron. Output from here goes to the subthalamic ... In the primate most of these axons are thin and unbranched. The striatum does not receive axons from the primary olfactory, ...
Plasmodium coatneyi
Due to the fact that it is a species of Plasmodium which only causes malaria in nonhuman primates, no treatment for this form ... "Center of Disease Control". About Malaria. CDC. Retrieved 25 October 2013. "Ookinete". Dictionary.com. Retrieved 2 November ... Plasmodium coatneyi is a parasitic species that is an agent of malaria in nonhuman primates. P. coatneyi occurs in Southeast ... Plasmodium coatneyi was isolated from an Anopheles hackeri before being found in its primate host species. This was the first ...
Laverania
Coatney, G.R.; National Institute of Allergy and Infectious Diseases (1971). The primate malarias. U.S. National Institute of ... The first non-human primate parasites were described by Eduard Reichenow in Cameroon in 1920. He observed three morphologically ... Allergy and Infectious Diseases. Rayner JC, Liu W, Peeters M, Sharp PM, Hahn BH (May 2011). "A plethora of Plasmodium species ...
Plasmodium falciparum
The primate malarias. Division of Parasitic Disease, CDC. p. 263. Rich, S. M.; Leendertz, F. H.; Xu, G.; Lebreton, M.; Djoko, C ... It was the Romans who named the disease "malaria"-mala for bad, and aria for air, as they believed that the disease was spread ... E. A. Beet, a doctor working in Southern Rhodesia (now Zimbabwe) had observed in 1948 that sickle-cell disease was related to a ... Historically, the parasite and its disease had been most well known in Europe. But medical programmes since the early 20th ...
Plasmodium malariae
Division of Parasitic Disease, CDC. p. 209. Collins WE, Jeffery GM (October 2007). "Plasmodium malariae: parasite and disease ... Coatney GR, Collins WE, Warren M, Contacos PG (1971). "18 Plasmodium malariae (Grassi and Feletti, 1890)". The primate malarias ... The Centers for Disease Control (CDC) has an application that allows people to view specific parts of the world and how they ... William E. Collins from the Center of Disease Control (CDC), chloroquine is most commonly used for treatment and no evidence of ...
Plasmodium vivax
The primate malarias. Division of Parasitic Disease, CDC. pp. 43-44. LCCN 71-610655. White, N. J. (15 January 2008). " ... A single infectious bite can trigger six or more relapses a year, leaving patients more vulnerable to other diseases. Other ... Lastly, antimalarial drugs can also be used to prevent infection from developing into a clinical disease. However, there has ... In 1979, World Health Organization declared the Korean peninsula vivax malaria-free, but the disease unexpectedly re-emerged in ...
Plasmodium knowlesi
Coatney GR, Collins WE, Warren M, Contacos PG (1971). The Primate Malarias. Atlanta, GA: Division of Parasitic Diseases, U.S. ... Those with severe disease may experience shortness of breath, abdominal pain, and vomiting. As disease progresses, parasites ... Primates are infected through the bite of an infected Anopheles mosquito which carries a parasite stage called the sporozoite ... Parasitic Diseases (PDF) (7 ed.). Parasites Without Borders. p. 112. "Treatment of uncomplicated malaria caused by P. vivax, P ...
Animal testing on non-human primates
In infectious disease research, China invests more than the U.S. does in conducting research on non-human primates. "Select ... Adrien, Claudia (2018-10-10). "China ahead of United States in non-human primate infectious disease research". Homeland ... laboratories", Project R&R. Nonhuman Primate(NHP)Disease Models from animal research institutions. (Webarchive template wayback ... Biomedical Primate Research Centre, the largest primate test centre in Europe Great Ape Project Great Ape research ban ...
Lilongwe Wildlife Centre
"Primate Release - Lilongwe Wildlife Trust". Lilongwewildlife.org. Retrieved 2016-08-08. "Disease Screening - Lilongwe Wildlife ... Key projects include urban hyaena relocation, adaptation of primates released into the wild, and disease screening for captive ... International Primate Society and International Primate Protection League. In 2011, Lilongwe Wildlife Centre received a ... "PASA Welcomes Lilongwe Wildlife Centre : PASA Primates". www.pasaprimates.org. Archived from the original on 8 December 2015. ...
Animal testing
"Nonhuman primate models of Parkinson's disease". ILAR Journal. 48 (4): 339-55. doi:10.1093/ilar.48.4.339. PMID 17712221. McKie ... "U.S. primate import statistics for 2014". International Primate Protection League. Archived from the original on 4 July 2017. ... U.S. Primate Imports Spike International Primate Protection League April 2007 Duncan IJ, Petherick JC (1991). "The implications ... "Towards a transgenic model of Huntington's disease in a non-human primate". Nature. 453 (7197): 921-24. Bibcode:2008Natur.453.. ...
Plasmodium cynomolgi
Nonhuman Primates in Biomedical Research: Diseases. Elsevier. pp. 299-324. Cormier LA (15 September 2011). "Ethics: Human ... The effect of infection on primate hosts has primarily been studied in rhesus monkeys, where P. cynomolgi generally causes mild ... Martinelli A, Culleton R (2018). "Non-human primate malaria parasites: out of the forest and into the laboratory". Parasitology ... Within Plasmodium, P. cynomolgi is in the subgenus Plasmodium, containing all species of Plasmodium that infect primates ( ...
Southwest National Primate Research Center
The SNPRC became the seventh National Primate Research Center in 1999. The SNPRC has two scientific units: "Infectious Diseases ... The center houses over 2,500 non-human primates. Among the primates held in captivity at the SNPRC are baboons, chimpanzees, ... "Primates". Southwest National Primate Research Center. Retrieved 13 September 2020. Elizabeth Pannill (June 2, 2014). "USDA ... Primate research centers, Animal testing on non-human primates, Medical research institutes in Texas, Biomedical research ...
Olive baboon
Competition and disease have possibly led to fewer baboons in closed forests. Like most other baboon species, it is routinely ... Strier, Karen (2011). Primate Behavioral Ecology (4th ed.). Upper Saddle River: Prentice Hall. ISBN 978-0-205-79017-3. coss ( ... Groves, C. P. (2005). "Order Primates". In Wilson, D. E.; Reeder, D. M (eds.). Mammal Species of the World: A Taxonomic and ... Groves, C. (2001). Primate Taxonomy. Washington DC: Smithsonian Institution Press. ISBN 1-56098-872-X. Rowell, T. E. (1966). " ...
Taura syndrome
"Nonsusceptibility of primate cells to Taura syndrome virus". Emerging Infectious Diseases. 10 (12): 2106-2112. doi:10.3201/ ... The disease has three distinct phases that sometimes overlap: acute, transition and chronic. The disease cycle has been ... Jim Brock, the aquatic disease specialist for the State of Hawaii during this period, first demonstrated the disease could be ... "Seabirds as Vectors for Penaeid Shrimp Viral Diseases". Retrieved September 27, 2008. "Viral diseases-Taura syndrome". ...
Erythroparvovirus
Primates serve as natural hosts. There are seven species in this genus. Diseases associated with this genus include fifth ... Pinniped erythroparvovirus 1 Primate erythroparvovirus 1 Primate erythroparvovirus 2 Primate erythroparvovirus 3 Primate ... Primates serve as the natural host. Transmission routes are oral and respiratory. Cotmore, SF; Agbandje-McKenna, M; Canuti, M; ... disease and skin lesions. The following seven species are assigned to the genus: ...
Lion
Sparks, J. (1967). "Allogrooming in primates: a review". In Morris, D. (ed.). Primate Ethology (2011 ed.). Chicago: Aldine. pp ... ISBN 978-0-07-136333-4. Patterson, B. D.; Neiburger, E. J.; Kasiki, S. M. (2003). "Tooth Breakage and Dental Disease as Causes ... Primary causes of the decline include disease and human interference. In 1975, it was estimated that since the 1950s, lion ... Myers, D. L.; Zurbriggen, A.; Lutz, H.; Pospischil, A. (1997). "Distemper: not a new disease in lions and tigers". Clinical ...
Joe Martin (orangutan)
"Respiratory System Diseases of Nonhuman Primates". Nonhuman Primates in Biomedical Research. Vol. 2: Diseases (2nd ed.). ... Individual primates in the United States, Primate attacks, Year of birth unknown, Year of death unknown). ... As with all primates, the mother-child dyad is foundational to infant survival, and young orangutans are heavily dependent on ... The writer also made impressive primate cognition claims about Joe Martin: "The remarkable animal understands any spoken ...
Sociality and disease transmission
Griffin, Randi H.; Nunn, Charles L. (21 September 2011). "Community structure and the spread of infectious disease in primate ... We occupy less than half of the social network structures that characterize non-human primates; however, among primates we can ... "Global perspectives for prevention of infectious diseases associated with mass gatherings". The Lancet Infectious Diseases. 12 ... Diseases such a tuberculosis have long incubation periods, which creates another obstacle since it separates the point of ...
Low copy repeats
Bailey, Jeffrey A.; Eichler, EE (2006). "Primate segmental duplications: crucibles of evolution, diversity and disease". Nature ... Primate Gene and Genome Evolution Driven by Segmental Duplication of Chromosome 16 (PDF) (Ph.D.). Case Western Reserve ... LCRs comprise a large portion of the human genome owing to a significant expansion during primate evolution. In humans, ...
Bertielliasis
... and there is close contact with soil and/or nonhuman primates. In many of these areas, other parasitic diseases can be a ... The disease is reportedly endemic to 29 countries. In documented cases in Mauritius, the infection was traced back to the ... For Bertiella, nonhuman primates are generally the definitive host, and oribatid mites are the intermediate host. Human ... The most common way to prevent this infection in humans is to avoid contact with nonhuman primates and the soil in their ...
Thomas Gillespie (epidemiologist)
"Pathogens, primates & human populations, oh my!". janegoodall.org. Retrieved 22 September 2020. Carrington, Damian (24 March ... He has, also, guided international efforts to protect endangered species from human diseases and prevent future pandemics. ... Kimbrough, Liz (3 April 2014). "Next big idea in forest conservation? Connecting deforestation to disease". Mongabe. Sullivan, ... "Effects of logging on gastrointestinal parasite infections and infection risk in African primate populations". Journal of ...
2019 in primate paleontology
Gili Greenbaum; Wayne M. Getz; Noah A. Rosenberg; Marcus W. Feldman; Erella Hovers; Oren Kolodny (2019). "Disease transmission ... A study on frequency of insectivory in primates, its possible causes and its implications for the hypotheses of primate ... "Macroevolutionary effects on primate trophic evolution and their implications for reconstructing primate origins". Journal of ... This article records new taxa of fossil primates of every kind are scheduled to be described during the year 2019, as well as ...
Marcia Stefanick
Stefanick's research focuses on chronic disease prevention in both women and men most commonly heart disease, breast cancer, ... Stefanick worked at the Oregon Regional Primate Research Center. She earned her Ph.D. in Physiology from Stanford University in ... on chronic disease prevention. Her major focus is heart disease, breast cancer, osteoporosis, and dementia. Stefanick was born ... She has published with the WHI on the impact of exercise on chronic disease through the WHISH study. Stefanick is the Principal ...
Mitochondrial disease
"Mitochondrial gene replacement in primate offspring and embryonic stem cells". Nature. 461 (7262): 367-372. Bibcode:2009Natur. ... diabetes Huntington's disease cancer Alzheimer's disease, Parkinson's disease bipolar disorder, schizophrenia, aging and ... Mitochondrial diseases take on unique characteristics both because of the way the diseases are often inherited and because ... Mitochondrial disease can manifest in many different ways. Examples of mitochondrial diseases include: Mitochondrial myopathy ...
Discovery of disease-causing pathogens
Both HIV-1 and HIV-2 are of primate origin. The origin of HIV-1 is the central common chimpanzee (Pan troglodytes troglodytes) ... "Nationally Notifiable Infectious Diseases - 2007". Center for Disease Control. 2007. Archived from the original on 2007-06-24. ... Since 2002, Giardia cases must be reported to the Center for Disease Control, according to the CDC's Reportable Disease ... Cyclospora infection must be reported to the Center for Disease Control according to the CDC's Reportable Disease Chart The ...
Segmental duplication on the human Y chromosome
2006). Primate segmental duplications: crucibles of evolution, diversity and disease. Nat Rev Genet 7:552-564. Kirsch, Stefan. ... However, when the levels of segmental duplication in primates are compared with other mammals, we see that primates on average ... It is estimated that it has a recent origin to within the last thirty million year of primate evolution. Further FISH testing ... Most human segmental duplications are less than 300 kb in length, whereas research has begun to show that other primates, such ...
Pan African Sanctuary Alliance
"Noninvasive test for tuberculosis detection among primates". Emerging Infectious Diseases. 21 (3): 468-470. doi:10.3201/ ... and other threats to primate habitats. Nearly three-quarters of PASA sanctuaries conduct anti-poaching patrols in primate ... Lwiro Primate Rehabilitation Centre (DRC) Ngamba Island (Chimpanzee Sanctuary and Wildlife Conservation Trust) (Uganda) Project ... promoting the conservation of wild primates, educating the public, empowering communities, and working to stop the illegal ...
Jean-Paul Gonzalez
He worked as a fellow at the Center for Disease Control and Prevention in Atlanta and Fort Collins, and as a visiting professor ... Gonzalez JP, Prugnolle F, Leroy E (2013). "Men, primates, and germs: an ongoing affair". One Health: The Human-Animal- ... In 2017 he was appointed at Deputy Director of the Center of Excellence for Animal and Zoonotic Diseases (CEEZAD), Kansas State ... Gonzalez is a virologist whose main fields of research encompass the fundamentals and domains of disease emergence, viral ...
Nematopsis
Gregarine disease of penaeid shrimp is a common disease caused by Nematopsis spp. that affects shrimp in the United States, ... "Nonhuman Primates in Biomedical Research (Second Edition)". Nonhuman Primate Models for Human Malaria Research. Gutierrez- ... Gregarine Disease of Penaeid Shrimp. 1996. Accessed from: http://www.dfo-mpo.gc.ca/science/aah-saa/diseases-maladies/gregdpsp- ... "Disease of mollusca: bivalvia." Diseases of marine animals. 2. Retrieved from: https://www.intres.com/archive/doma_books/DOMA_ ...
National Primate Research CenterHumansNonhuman Primate ModelParkinson'sPopulationsNHPsDegenerative diseasesSimianCoronavirus disease 2019SpeciesCenters for DiseasResearchersViralBiomedical ResearchLaboratoryEmerging InfectioAlzheimer'sNeuronsModelNPRCScientistsInfectionLaboratoriesNeurodegenerativeRespiratoryMacaqueQuarantineConservationVaccinePathologyCellsDosesNeuralCenterBehaviorOutbreaksZoonoticDiversityRodentVirusesMiceStudiesMechanismsRare diseasesRhesus monkeysMonkeysKidneyGeneticImplicationsModelsMutationsAnimalPreventionLemursProcessesInfectionsClinical
National Primate Research Center2
- Dr. John Morrison , Director of the California National Primate Research Center (CNPRC) and a professor at the University of California, Davis, explained that AD's slow progression reflects the remarkable resilience of brain circuits to damage. (nih.gov)
- In a similar study of young rhesus monkeys (7-14 years old) at the Wisconsin National Primate Research Center, researchers found a trend towards longer lifespans for calorie restricted animals after they had discounted what they felt were not age-related deaths. (scienceblogs.com)
Humans13
- The clinical manifestations of the disease caused by HIV in humans is comparable in many ways to the disease caused by SIV in non-human primates. (nih.gov)
- The incidence of neuropsychologic and neurologic disease that occurs in HIV-infected humans also occurs in SIV-infected monkeys, and the neuropathologic findings in both populations are nearly indistinguishable. (nih.gov)
- Humans have acquired the disease from nosocomial transmission (often by contaminated needles) and from person-to-person transmission to those in close contact with blood or secretions from seriously ill patients. (cdc.gov)
- The study, Sanes said, offers an important foundation for researchers to build on as they seek to understand how vision works in primates, including humans, and how it can be disrupted by disease. (nih.gov)
- Nonhuman primates, by virtue of their genetic, physiologic, and sometimes social similarities to humans, are particularly likely sources of infectious agents that pose a threat to humans ( 1 , 2 ). (cdc.gov)
- scientists now theorize that SIVs were transmitted from primates to humans on several occasions ( 3 , 4 ). (cdc.gov)
- As a result, concern is increasing that other infectious agents enzootic in primate populations may endanger humans ( 5 ). (cdc.gov)
- Because SFV is not known to occur naturally in humans, detecting serologic or molecular evidence, or both, of infection in a human, along with a history of close contact with primates, constitutes strong evidence for primate-to-human transmission, i.e., a marker for cross-species transmission ( 28 ). (cdc.gov)
- The testes in humans may act as mutation multipliers that raise the odds of passing improved DNA to offspring - but that can also backfire by increasing the frequency of certain diseases. (news-medical.net)
- In humans and NHPs, interventions were typically given to both sexes well after the PD phenotype was established, and clinical outcome measures were collected at single (symptomatic) or multiple (disease-modifying) time-points. (plos.org)
- The evolution of Trypanosomes infecting humans and primates. (ajtmh.org)
- Ebola hemorrhagic fever is a severe, often-fatal disease in humans and primates that has appeared sporadically since its initial recognition in 1976. (conservapedia.com)
- Four of the five have caused disease in humans: Ebola-Zaire, Ebola-Sudan, Ebola-Ivory Coast and Ebola-Bundibugyo. (conservapedia.com)
Nonhuman Primate Model1
- Development of a coronavirus disease 2019 nonhuman primate model using airborne exposure. (bvsalud.org)
Parkinson's12
- The pathophysiology of these cells that occurs with HIV disease is likely to be similar, at least in part, to that which occurs in several neurodegenerative diseases, such as multiple sclerosis, Alzheimer's and Parkinson's diseases, and perhaps many other. (nih.gov)
- Personalized stem cells improved motor symptoms and depression signs in monkeys modeling Parkinson's disease, paving the way for trials in human patients. (the-scientist.com)
- A team of scientists has made an important advance in the development of patient-specific stem cells that could impact the study and treatment of diseases such as diabetes, Parkinson's, and Alzheimer's. (sciencedaily.com)
- A team of scientists led by Dieter Egli and Scott Noggle at The New York Stem Cell Foundation (NYSCF) Laboratory in New York City has made an important advance in the development of patient-specific stem cells that could impact the study and treatment of diseases such as diabetes, Parkinson's, and Alzheimer's. (sciencedaily.com)
- The ultimate goal of this study is to save and enhance lives by finding better treatments and eventually cures for diabetes, Alzheimer's, Parkinson's and other debilitating diseases and injuries affecting millions of people across the US and the globe," said NYSCF CEO Susan L. Solomon. (sciencedaily.com)
- Ageing is the greatest risk factor for the development of Parkinson's disease. (elsevierpure.com)
- However, the current dogma holds that cellular mechanisms that are associated with ageing of midbrain dopamine neurons and those that are related to dopamine neuron degeneration in Parkinson's disease are unrelated. (elsevierpure.com)
- We propose, based on evidence from studies of non-human primates, that normal ageing and the degeneration of dopamine neurons in Parkinson's disease are linked by the same cellular mechanisms and, therefore, that markers of cellular risk factors accumulate with age in a pattern that mimics the pattern of degeneration observed in Parkinson's disease. (elsevierpure.com)
- We contend that ageing induces a pre-parkinsonian state, and that the cellular mechanisms of dopamine neuron demise during normal ageing are accelerated or exaggerated in Parkinson's disease through a combination of genetic and environmental factors. (elsevierpure.com)
- Collier, TJ, Kanaan, NM & Kordower, JH 2011, ' Ageing as a primary risk factor for Parkinson's disease: Evidence from studies of non-human primates ', Nature Reviews Neuroscience , vol. 12, no. 6, pp. 359-366. (elsevierpure.com)
- Parkinson's disease (PD) was used to compare patterns of preclinical study design for symptomatic and potentially disease-modifying interventions. (plos.org)
- Zeiss CJ, Allore HG, Beck AP (2017) Established patterns of animal study design undermine translation of disease-modifying therapies for Parkinson's disease. (plos.org)
Populations4
- Wild primate populations in emerging infectious disease research: the missing link? (nih.gov)
- Fewer data are available on the seroprevalence of antibodies to SFV among free-ranging populations of primates. (cdc.gov)
- I'm hoping it will provide an easier method to noninvasively monitor viruses in primate populations because with species such as mountain gorillas, it's easier to collect chewed plants than fecal samples," said Evans. (mongabay.com)
- This intervention aims to prevent the spread of viral and bacterial diseases from newly introduced primates to resident primate populations. (conservationevidence.com)
NHPs3
- In a recent article published in Science Translational Medicine , researchers conducted a prospective study in mice and nonhuman primates (NHPs) to determine the impact of Notch signaling in T cells during acute gastrointestinal graft-versus-host disease (GI-aGVHD). (astct.org)
- The overall objective of the NPRC program is to provide support for scientists who use nonhuman primates (NHPs) in their research by providing the animals, facilities, and scientific and veterinary expertise needed to enable research using NHPs as well as to support training opportunities. (nih.gov)
- The Centers continue to develop and enhance NHP models of human disease as NHPs provide the translation link to human studies. (nih.gov)
Degenerative diseases1
- This is an important step toward generating stem cells for disease modeling and drug discovery, as well as for ultimately creating patient-specific cell-replacement therapies for people with diabetes or other degenerative diseases or injuries," said Rudolph L. Leibel, MD, co-director of Columbia's Naomi Berrie Diabetes Center and a collaborator in the study. (sciencedaily.com)
Simian4
- We describe the first reported transmission to a human of simian foamy virus (SFV) from a free-ranging population of nonhuman primates in Asia. (cdc.gov)
- Serologic studies have demonstrated evidence of primate-to-human transmission of simian retrovirus (SRV), a retrovirus enzootic among Old World monkeys, in laboratory workers exposed to captive primates ( 10 ). (cdc.gov)
- Finally, in the past decade, evidence of infection with simian foamy virus (SFV) has been identified in 1% to 4% of persons who come into frequent contact with primates in zoos and primate laboratories and among 1% of bushmeat hunters in Central Africa ( 11 - 15 ). (cdc.gov)
- He has contributed to the development and characterization of a variety of infectious disease models in nonhuman primates including simian immunodeficiency virus/HIV, Zika virus, streptococcal pneumonia, Lyme disease, respiratory syncytial virus, and most recently organized and provided oversight of animal model development for the SARS-CoV-2 rhesus macaque and African green monkey animal models at the Tulane NPRC. (ohsu.edu)
Coronavirus disease 20191
- Two doses of an experimental vaccine to prevent coronavirus disease 2019 (COVID-19) induced robust immune responses and rapidly controlled the coronavirus in the upper and lower airways of rhesus macaques exposed to SARS-CoV-2, report scientists from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. (nih.gov)
Species4
- Phylogenetic analyses of SFVs indicate a species-specific distribution of virus strains not unlike that of SIV among some African primate species ( 19 - 23 ). (cdc.gov)
- Science currently recognizes about 650 species or subspecies of apes, monkeys, and prosimians (a group, including lemurs, lorises, and bush babies, that split off on its own early in primate evolution), six of them first described by Mittermeier himself. (audubon.org)
- Species-specific patterns of study design prevailed regardless of whether interventions were symptomatic or potentially disease-modifying. (plos.org)
- Zoonotic diseases are distributed across space, time, and species. (caryinstitute.org)
Centers for Diseas4
- Centers for Disease Control and Prevention. (cdc.gov)
- The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
- The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
- Routine tuberculin skin testing for TB (either annually or semiannually) is required for all animal welfare inspectors, but sufficient information could not be obtained to determine TB infection or conversion rates, or to evaluate whether the tests had been conducted and interpreted according to current Centers for Disease Control and Prevention (CDC) guidelines. (cdc.gov)
Researchers3
- A team of researchers led by Harvard's Joshua Sanes applied high-throughput genetic sequencing methods to create the first cellular atlas of the primate retina. (nih.gov)
- The density of transposable (jumping) elements between sex chromosomes in primates may have important consequences for the studies of human genetic diseases, say Penn State University researchers. (news-medical.net)
- Doctors and researchers at Nationwide Children's Hospital have developed a new mouse model of vesicoureteral reflux, a common childhood condition that can lead to chronic kidney disease in children. (news-medical.net)
Viral4
- This is the first time an experimental COVID-19 vaccine tested in nonhuman primates has been shown to produce such rapid viral control in the upper airway, the investigators note. (nih.gov)
- A COVID-19 vaccine that reduces viral replication in the lungs would limit disease in the individual, while reducing shedding in the upper airway would potentially lessen transmission of SARS-CoV-2 and consequently reduce the spread of disease, they add. (nih.gov)
- Scientific Resources Program, Div of Viral and Rickettsial Diseases, Center for Infectious Diseases, CDC. (cdc.gov)
- Applied alongside fecal and urine sampling, the new technique could help understand the most common pathways of viral spreading in wild primates. (mongabay.com)
Biomedical Research1
- Dr. Bohm has over 30 years of experience in nonhuman primate biomedical research focused in the areas of infectious disease model development, nonhuman primate medicine and surgery, nonhuman primate breeding colony management and preventive medicine programs, and animal resources administration. (ohsu.edu)
Laboratory6
- The animal facilities and animal care and use program of the U.S. Army Medical Research Institute of Infectious Diseases are accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International. (medscape.com)
- SFV is present in highest concentrations in the saliva of infected laboratory macaques ( Macaca mulatta and M . fascicularis ) and African green monkeys ( Cercopithecus aethiops ), which suggests that bites, scratches, and mucosal splashes with saliva from primates are likely mechanisms of transmission ( 25 - 27 ). (cdc.gov)
- 3 Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu, China. (nih.gov)
- 1 Institute of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China. (jci.org)
- Address correspondence to: Yuejun Chen, Professor, Institute of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China. (jci.org)
- He was the Director of the Tulane University Laboratory Animal Medicine Residency/Post-doctoral fellowship Program and Director of the Tulane Center of Excellence for Emerging and Re-emerging Infectious Disease Research. (ohsu.edu)
Emerging Infectio1
- His specialization is in veterinary pathology and the use of animal models to best mimic human diseases as a means to understand pathogenic mechanisms of emerging infectious diseases and as a platform to evaluate efficacy of medical countermeasures. (bu.edu)
Alzheimer's7
- The CNPRC's current Director, Dr. John H. Morrison was inducted into the National Academy of Medicine in 2016 due to his groundbreaking work in the area of Alzheimer's disease and the aging brain. (ucdavis.edu)
- Your support will provide critical resources to advance this important work as we stride to develop treatments for the patients with Alzheimer's and to provide ways to avoid the development of the disease altogether. (ucdavis.edu)
- Amyloid β (Aβ) protein immunotherapy lowers cerebral Aβ and improves cognition in mouse models of Alzheimer's disease (AD). (nih.gov)
- Alzheimer's disease (AD) affects more than 5.5 million Americans per year . (nih.gov)
- Accumulation of tau protein leads to the development of neurofibrillary tangles in the brain, an effect that is associated with Alzheimer's disease. (nih.gov)
- Visualization of biomarkers in the brain of nonhuman primate models may provide key insights into the progression of Alzheimer's disease. (nih.gov)
- We often say that we find the cure to cancer and Alzheimer's disease in rodent models, but when we move to the clinic, it's not working," said Dr. Danielle Beckman, a postdoctoral fellow at CNPRC and the lead author of the Alzheimer's and Dementia study. (nih.gov)
Neurons3
- Cold Spring Harbor, NY - The ability to comprehensively map the architecture of connections between neurons in primate brains has long proven elusive for scientists. (cshl.edu)
- Thus, aberrant upregulation of the glycolytic enzyme PFKFB3 in neurons may contribute to CLN7 pathogenesis and targeting PFKFB3 could alleviate this and other lysosomal storage diseases. (nature.com)
- Here, using the Cln7 ∆ex2 mouse model of CLN7 disease, we found an aberrant upregulation of pro-glycolytic enzyme PFKFB3 in neurons that may contribute to CLN7 pathogenesis. (nature.com)
Model6
- Non-human primates have been used to model psychiatric disease for several decades. (nature.com)
- In this review we will focus on efforts to understand the consequence of postnatal experiences that have been used to model developmental aspects of psychopathology in non-human primates. (nature.com)
- NIH has been working with the FDA toward development and use of a non-human primate model of pertussis disease and transmission. (nih.gov)
- The translational gap for potentially disease-modifying interventions in PD in part results from study designs, particularly in mice, that fail to model the progressive nature and relatively late intervention characteristic of PD, or that anchor mechanistic and neuropathologic data to longitudinal clinical outcomes. (plos.org)
- Here, we found, in the Cln7 ∆ex2 mouse model of CLN7 disease, that failure in autophagy causes accumulation of structurally and bioenergetically impaired neuronal mitochondria. (nature.com)
- We hope that our work spawns a new model organism and deep understanding of primate biology, while establishing a new and ethical way of doing genetics that bridges biological, behavioral, medical, and conservation research. (stanford.edu)
NPRC2
- Prior to his appointment as ONPRC Director in 2023, he served on senior leadership teams at two National Primate Research Centers (NPRC) as Associate Director, Attending Veterinarian, and Division Chair. (ohsu.edu)
- He is an ad hoc nonhuman primate specialist for the AAALAC and has served on several NPRC National Scientific Advisory Boards. (ohsu.edu)
Scientists1
- The IEDWG utilizes expertise of NHP scientists to ready a rapid response to infectious disease outbreaks and potential pandemics. (ohsu.edu)
Infection8
- Chronicwastingdisease,apriondiseaseofcervids, agent infection was made by using immunoblotting and mayinfecthumans,butthisisunproven.Primatesfrom2 immunohistochemical testing to determine accumulation generawereobservedfor9-10yearsafterintracerebral of abnormal, disease-associated prion protein (PrPres) in or oral inoculation. (cdc.gov)
- This RFA, Non-Human Primate Models for HIV/CNS Disease, is related to the priority area of neurological effects of HIV infection. (nih.gov)
- Extensive investigation at transit points in Amsterdam and New York did not implicate cross-infection of the monkeys by African primates. (cdc.gov)
- Editorial Note: The episodes documented in Virginia and Pennsylvania are the first known instances of Ebola-related filovirus infection in imported primates in the United States. (cdc.gov)
- To date, no disease has been linked to human infection with SRV. (cdc.gov)
- The oral transmission of Chagas disease: an acute form of infection responsible for regional outbreaks. (ajtmh.org)
- The disease is caused by infection with Ebola virus, first discovered in Africa. (conservapedia.com)
- After initial infection, the disease can pass from person to person in several ways. (conservapedia.com)
Laboratories1
- A spending bill approved by a House committee would require the agency to "accelerate" the replacement of nonhuman primates in laboratories starting in October. (the-scientist.com)
Neurodegenerative5
- MELBOURNE, Australia and SAN FRANCISCO, Dec. 04, 2023 (GLOBE NEWSWIRE) -- Alterity Therapeutics (ASX: ATH, NASDAQ: ATHE) ("Alterity" or "the Company"), a biotechnology company dedicated to developing disease modifying treatments for neurodegenerative diseases, will be hosting an investor webcast on Wednesday, 6 December 2023 in Australia / Tuesday, 5 December 2023 in the United States. (yahoo.com)
- MELBOURNE, Australia and SAN FRANCISCO, Nov. 27, 2023 (GLOBE NEWSWIRE) -- Alterity Therapeutics (ASX: ATH, NASDAQ: ATHE) ("Alterity" or "the Company"), a biotechnology company dedicated to developing disease modifying treatments for neurodegenerative diseases, today announced a poster presentation from the Company's Biomarkers of progression in Multiple System Atrophy (bioMUSE) Natural History Study at the recent 34th International Symposium on the Autonomic Nervous System (AAS). (yahoo.com)
- Translation of disease-modifying therapies in neurodegenerative disease has been disappointing. (plos.org)
- CLN7 neuronal ceroid lipofuscinosis is an inherited lysosomal storage neurodegenerative disease highly prevalent in children. (nature.com)
- The neuronal ceroid lipofuscinoses (NCLs) are a family of monogenic life-limiting pediatric neurodegenerative disorders collectively known as Batten disease 1 . (nature.com)
Respiratory2
Macaque1
- And in comparison with extensively studied primates like the macaque, marmosets can be easier to study because their brain surfaces are flatter than the more folded cortical surfaces of larger primates. (cshl.edu)
Quarantine3
- In November 1989, infections caused by a filovirus closely related to Ebola virus were detected in cynomolgus (Macaca fascicularis) monkeys imported from the Philippines and held in a primate quarantine facility in Virginia (1). (cdc.gov)
- Nonetheless, CDC has developed the following interim guidelines that update and modify the procedures used in the transportation and quarantine of nonhuman primates. (cdc.gov)
- Quarantine programmes are designed to facilitate the detection of transmittable diseases and make accurate assessments of the overall health status of individuals and/or groups coming into contact with a new population. (conservationevidence.com)
Conservation3
- Disease risk analysis: a tool for primate conservation planning and decision making. (nih.gov)
- Give as you Live Online is the free and easy way to raise money for Neotropical Primate Conservation when you shop online with 6,000+ stores. (giveasyoulive.com)
- Simply sign up for an account and start shopping to make a difference for Neotropical Primate Conservation! (giveasyoulive.com)
Vaccine3
- For vaccine studies using primates, we adapted the optimal immunization regimens determined from the rodent studies. (medscape.com)
- Evaluation of the mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates. (nih.gov)
- NIAID has supported the NHP Reagent Resource since fiscal year (FY) 2004 to fill a critical scientific need for scarce in vitro and in vivo reagents, enabling rigorous and innovative clinically-relevant research with NHP animal models for vaccine and adjuvant development, transplantation, and infectious and immune-mediated diseases. (nih.gov)
Pathology2
- This request for applications (RFA) will solicit research grants directed toward expanding the use of SIV-infected non-human primates to address the effects of this virus on the CNS to increase understanding of the resulting pathology and identify therapeutic targets for prevention and/or treatment of the functional and neurological consequences. (nih.gov)
- Late Disseminated Lyme Disease: Associated Pathology and Spirochete Persistence Posttreatment in Rhesus Macaques. (bu.edu)
Cells8
- When the right gene is expressed in the right manner in the right population of stem cells, the developing mouse brain can exhibit primate-like features. (mpg.de)
- This altered the behavior of these cells to one that is akin to that of progenitors in the developing primate neocortex. (mpg.de)
- The EasySep™ Non-Human Primate B Cell Isolation Kit is designed to isolate untouched and highly purified B cells from fresh or previously frozen non-human primate peripheral blood mononuclear cells (PBMCs) in as little as 20 minutes by immunomagnetic negative selection. (stemcell.com)
- The achievement is significant because such patient-specific cells potentially can be transplanted to replace damaged or diseased cells in persons with diabetes and other diseases without rejection by the patient's immune system. (sciencedaily.com)
- The specialized cells of the adult human body have an insufficient ability to regenerate missing or damaged cells caused by many diseases and injuries," said Dr. Egli, NYSCF senior scientist in the study. (sciencedaily.com)
- But if we can reprogram cells to a pluripotent state, they can give rise to the very cell types affected by disease, providing great potential to effectively treat and even cure these diseases. (sciencedaily.com)
- Our hope is that we can eventually overcome the remaining hurdles and use patient-specific stem cells to treat and cure people who have diabetes and other diseases. (sciencedaily.com)
- Administration of the highly selective PFKFB3 inhibitor AZ67 in Cln7 ∆ex2 mouse brain in vivo and in CLN7 patients-derived cells rectifies key disease hallmarks. (nature.com)
Doses3
- Because of the high degree of genetic and physiologic similarity of nonhuman primates to human beings, this resource is a critical component of translational long-term assessment of candidate radiation mitigators, in an experimental setting under which relevant doses of whole-body irradiation and partial body irradiation with 5% bone marrow sparing can be studied in otherwise healthy subjects. (nih.gov)
- Although TGN1412 is harmless to other primates at high doses, it sent the immune systems of six people into near-deadly overdrive, causing widespread inflammation and multiple-organ failure. (rationalresponders.com)
- In this study, we also endeavored to optimize the LEAPER 2.0 system further to establish robust RNA editing in non-human primates and humanized mice through AAV delivery at clinically reasonable doses. (biomedcentral.com)
Neural3
- A better understanding of primate neural connectivity promises to lead to fundamental therapeutic advances for human diseases. (cshl.edu)
- Among primates, the marmosets' relatively small brains lend themselves to thorough mapping of neural connections. (cshl.edu)
- With this new data and approach as a basis, Mitra and other neuroscientists are one step closer to making sense of the complex neural connections in the primate-and human-brain. (cshl.edu)
Center3
- CSHL Professor Partha Mitra , who conceptualized and collaboratively led the study as part of Brain/MINDS research conducted at the RIKEN Center for Brain Science in Japan, explains that the endgame for any large-scale brain study is to learn more about human brain architecture and how disease can affect it. (cshl.edu)
- Ms. Kendig joined the primate center in 2013. (ohsu.edu)
- After completing a one-year internship in Primate Medicine & Surgery at the ONPRC, she joined the Center faculty as a surgical veterinarian in 2008, where along with the Unit Head, she helped oversee the daily functions of the ARRS Surgical Services Unit. (ohsu.edu)
Behavior1
- Frans de Waal argues that the building blocks of human morality can be seen in the behavior of nonhuman primates like himpanzees. (dericbownds.net)
Outbreaks1
- This is a simple, noninvasive alternative to existing sampling options that could help monitor and prevent outbreaks in zoonosis-vulnerable threatened primates. (mongabay.com)
Zoonotic5
- In response to a September 1998 request from the United States Department of Agriculture, Animal and Plant Health Inspection Service (USDA/APHIS), a health hazard evaluation was conducted to assess potential zoonotic disease hazards encountered during animal welfare inspections. (cdc.gov)
- The inspections revealed a wide variation in environmental conditions and potential zoonotic disease hazards at these facilities. (cdc.gov)
- Recommendations are made in the report to strengthen the zoonotic disease prevention program for animal welfare inspectors. (cdc.gov)
- Our lab focuses on answering outstanding 'who, what, where' questions about zoonotic diseases. (caryinstitute.org)
- When do zoonotic disease threats grow and when do they diminish? (caryinstitute.org)
Diversity1
- Trypanosoma cruzi clonal diversity and the epidemiology of Chagas disease. (ajtmh.org)
Rodent1
- Detailed study design data were collected for 216 studies in non-human primate (NHP) and rodent toxin-induced models. (plos.org)
Viruses1
- PTLVs, primate T-lymphotropic viruses. (cdc.gov)
Mice2
- While mice are currently the mainstay for modeling human disease, the emergence of marmoset models of human neurological disorders has made marmosets a target of new research. (cshl.edu)
- Despite promising results in mice and rats that calorie restriction prolongs lifespan, results from the US National Institute on Aging (NIA) in Bethesda, MD were just published in Nature last week and concluded that calorie restriction for primates had no effect on longevity. (scienceblogs.com)
Studies3
- This research was funded by Brain Mapping of Integrated Neurotechnologies for Disease Studies (Brain/MINDS) from the Japan Agency for Medical Research and Development, AMED, the Crick-Clay Professorship (CSHL), the Mathers Foundation, the H.N. Mahabala Chair at IIT Madras, the ARC Centre of Excellence for Integrative Brain Function, and Monash University. (cshl.edu)
- The Radiation Late Effects Program facilitates the conduct of late-stage preclinical studies of mitigators of radiation damage in nonhuman primates. (nih.gov)
- Non-human primate studies of postnatal phenomenon have generally fallen into three basic categories: experiential manipulation (largely manipulations of rearing), pharmacological manipulation (eg drug-induced psychosis), and anatomical localization (defined by strategic surgical damage). (nature.com)
Mechanisms2
- We believe that the non-human primate provides a unique opportunity to examine the different mechanisms that confer either risk or resilience during development and a method of harnessing these sensitivities to protect individuals against the emergence of mental illness throughout life. (nature.com)
- The individual will be seen across the company and externally as a method/subject expert for immune mechanisms related to cardiometabolic and rare diseases, and for core technologies like flow cytometry. (biospace.com)
Rare diseases4
- NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. (nih.gov)
- This Special Issue of the journal Children constitutes an opportune moment to reflect on the psychosocial needs of children living with rare diseases and of their families. (mdpi.com)
- As medical advances, treatments, and developments have enabled many of these children to survive infancy and to live into adulthood, progress brings with it concerns and opportunities to enhance the psychosocial quality of life of children living with rare diseases, and of their families. (mdpi.com)
- In August of 2021, we released a call for papers whereby healthcare providers could share their experience and research on the psychosocial needs of children living with rare diseases, and the needs of their families. (mdpi.com)
Rhesus monkeys1
- The BPRC currently imprisons around 1,300 rhesus monkeys and marmosets, keeping them locked in cages and injecting them with debilitating diseases. (peta.org.uk)
Monkeys6
- Disease Agents at 41 months postinoculation (mpi) on average, and dis- ease developed in 2/12 orally infected squirrel monkeys in Nonhuman on average of 69 mpi ( 7 ). (cdc.gov)
- monkeys were the last orally infected monkeys to be eu- thanized because of clinical disease (80 and 107 mpi), and The Study the third heterozygote was clinically normal at 108 mpi. (cdc.gov)
- In December, a telephone survey of 40 other U.S. primate importers identified another shipment of cynomolgus monkeys that had arrived in Pennsylvania from the Philippines on November 28 and in which a number of unexplained deaths had occurred shortly after arrival. (cdc.gov)
- Inspection of the four major holding facilities in the Philippines, including the facility that had supplied the monkeys in Virginia, did not identify unusual illness compatible with Ebola virus disease in either workers or nonhuman primates. (cdc.gov)
- Aside from African green monkeys , nonhuman primate models that replicate airborne transmission of SARS-CoV-2 have not been investigated. (bvsalud.org)
- A comparative evaluation of COVID-19 in African green monkeys , rhesus macaques , and cynomolgus macaques following airborne exposure to SARS-CoV-2 was performed to determine critical disease parameters associated with disease progression , and establish correlations between primate and human COVID-19. (bvsalud.org)
Kidney1
- Kidney damage associated with chronic reflux is the fourth leading cause of chronic kidney disease and is the most common cause of severe hypertension in children. (news-medical.net)
Genetic1
- Programmable adenosine (A) to guanosine (G) editing could theoretically treat almost half of the genetic diseases caused by single-nucleotide polymorphisms (SNPs), including those leading to premature stop codons [ 16 ] or mutations at splicing sites [ 17 ]. (biomedcentral.com)
Implications1
- In this review we highlight general findings from the non-human primate postnatal developmental literature and their implications for primate models in psychiatry. (nature.com)
Models11
- Non-human primate models are poised to provide unique access to highly complex interactions between genes and early developmental experiences, and to the subsequent emergence and expression of mental illness in adulthood. (nature.com)
- Why are Primate Models Important to Biological Psychiatry? (nature.com)
- Primate models of mental processes have served psychiatry for decades particularly in the domains of higher cognitive processes, and auditory and visual image processing. (nature.com)
- These models have focused on primates to further the understanding of complex neurocognitive processes due to the similar complexities of the adult human and monkey brains. (nature.com)
- If you have expertise relevant to immunologic reagent production and development for nonhuman primate (NHP) models research, consider applying to NIAID's recently reissued funding opportunity announcement (FOA) Nonhuman Primate Reagent Resource (U24, Clinical Trial Not Allowed) . (nih.gov)
- The introduction of the FDA Animal Rule (2002) has propelled the development of preclinical animal models representing the human disease syndrome and the derivation of surrogate markers and correlates of protection. (hindawi.com)
- Dr. Morrison's team is developing nonhuman primate (NHP) models for AD that recapitulate the physiological effects of neurodegeneration associated with the disease. (nih.gov)
- Dr. Manuel Moro , NIA Health Scientist Administrator, underscored the value of ORIP's support for animal models in research on diseases of aging. (nih.gov)
- I think we really need to be open about new animal models for diseases. (nih.gov)
- The approach, which has never before been successfully attempted in primates, could lead to improved animal models for human biology and disease. (the-scientist.com)
- Dr. Hennebold's team also focuses on using recently developed gene editing techniques and assisted reproductive technologies to generate animal models of human diseases so that novel precision medicine-based therapies can be developed for their treatment. (ohsu.edu)
Mutations2
- A study suggests that mutations in the gene that encodes the T1R1/T1R3 taste receptor allowed primates that relied on insects for protein to transition to eating leaves and fruit. (the-scientist.com)
- Forty-six disease-causing mutations are recorded in the NCL mutation database (ucl.ac.uk/ncl-disease) in CLN7/MFSD8 , causing a broad phenotypic range, from classic late infantile CLN7 disease to non-syndromic retinal disease with onset in childhood or as late as the 7th decade 4 . (nature.com)
Animal1
- DISEASE IN NONHUMAN PRIMATES: The animal may be completely asymptomatic. (wustl.edu)
Prevention1
- HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. (nih.gov)
Lemurs3
- For beginners looking to jump-start their primate lists, take a trip to Madagascar, where lemurs, such as this black-and-white ruffed lemur, abound. (audubon.org)
- Mainly, though, Mittermeier was in Farafangana to bag two new lemurs to add to his already vast primate life list. (audubon.org)
- Mouse lemurs are the smallest, fastest developing, and most abundant primates in the world. (stanford.edu)
Processes2
- Given that treatment for CLN7 disease is likely to be more challenging than for NCLs encoding lysosomal enzymes such as ceroid lipofuscinosis, neuronal 2 (CLN2)/tripeptidyl peptidase 1 (TPP1) 11 here we aimed to understand the biochemical processes affected in CLN7 disease. (nature.com)
- Dr. Hennebold and his research team are leaders in primate reproductive biology, specifically in ovarian physiology and processes required for fertilization and early embryonic development. (ohsu.edu)
Infections3
- An overreactive immune system helps fend off infections, but it could also explain why we suffer from immune-system diseases like bronchial asthma, chronic hepatitis, and type I diabetes, which don't affect chimps. (rationalresponders.com)
- Contact with nonhuman primates was of greatest concern to the inspectors because of the similarities in pathogen susceptibility and the potential for acquiring medically important infections such as tuberculosis (TB) and B Virus. (cdc.gov)
- This disease has been described as one of the most feared infections of non-human primate handlers. (wustl.edu)
Clinical1
- The REGN421-treated recipients, however, ultimately developed other clinical and pathologic signs of skin, hepatic, or pulmonary aGVHD, but without GI disease. (astct.org)