Dimers and oligomers of flavan-3-ol units (CATECHIN analogs) linked mainly through C4 to C8 bonds to leucoanthocyanidins. They are structurally similar to ANTHOCYANINS but are the result of a different fork in biosynthetic pathways.
Exudate from seeds of the grape plant Vitis vinifera, composed of oils and secondary plant metabolites (BIOFLAVONOIDS and polyphenols) credited with important medicinal properties.
A plant species of the family VACCINIUM known for the sour fruit which is sometimes used for urinary tract infections.
A plant genus of the family EBENACEAE, order Ebenales, subclass Dilleniidae, class Magnoliopsida best known for the edible fruit and the antibacterial activity and compounds of the wood.
A plant genus in the family VITACEAE, order Rhamnales, subclass Rosidae. It is a woody vine cultivated worldwide. It is best known for grapes, the edible fruit and used to make WINE and raisins.
A group of FLAVONOIDS derived from FLAVONOLS, which lack the ketone oxygen at the 4-position. They are glycosylated versions of cyanidin, pelargonidin or delphinidin. The conjugated bonds result in blue, red, and purple colors in flowers of plants.
Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS). The two main types are HYDROLYZABLE TANNINS and CONDENSED TANNINS. Historically, the term has applied to many compounds and plant extracts able to render skin COLLAGEN impervious to degradation. The word tannin derives from the Celtic word for OAK TREE which was used for leather processing.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
A large class of organic compounds having more than one PHENOL group.
A group of phenyl benzopyrans named for having structures like FLAVONES.
A group of 3-hydroxy-4-keto-FLAVONOIDS.
The encapsulated embryos of flowering plants. They are used as is or for animal feed because of the high content of concentrated nutrients like starches, proteins, and fats. Rapeseed, cottonseed, and sunflower seed are also produced for the oils (fats) they yield.
Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.
A plant genus in the family CAPRIFOLIACEAE. The common name derives from its traditional use for menstrual cramps. It is a source of viburnine, valerianic acid, vibsanin, and ursolic acid. Note that true cranberry is VACCINIUM MACROCARPON.
A plant genus of the family POLYGONACEAE that is an ingredient of Shou-Wu-Pian, a Chinese herbal preparation (DRUGS, CHINESE HERBAL). The common name of black bindweed also refers to TAMUS or Fallopia (use POLYGONACEAE).
An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.
A plant genus of the family GERANIACEAE. The common name of geranium is also used for the GERANIUM genus.
Dimers (homo and hetero) of FLAVONOIDS.
The outer layer of the woody parts of plants.
A plant family of the order Malvales, subclass Dilleniidae, class Magnoliopsida of tropical trees.
A plant species of the family Ephedraceae, order Ephedrales, class Gnetopsida, division Gnetophyta. It is a source of EPHEDRINE and other alkaloids.
A plant genus of the family GROSSULARIACEAE. GAMMA-LINOLENIC ACID is obtained from the black currant oil of the seeds.
A plant genus of the family ROSACEAE. The common names of chokeberry or chokecherry are also used for some species of PRUNUS.
The fleshy or dry ripened ovary of a plant, enclosing the seed or seeds.
Measurement and evaluation of the components of substances to be taken as FOOD.
Fermented juice of fresh grapes or of other fruit or plant products used as a beverage.
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
Expanded structures, usually green, of vascular plants, characteristically consisting of a bladelike expansion attached to a stem, and functioning as the principal organ of photosynthesis and transpiration. (American Heritage Dictionary, 2d ed)
Use of plants or herbs to treat diseases or to alleviate pain.
Picrates are salts of picric acid, an explosive organic compound previously used as a yellow dye and antiseptic, which are now primarily used in chemical research and industrial applications. Please note that picrates should be handled with care due to their potential explosiveness when heated or subjected to friction.
Inorganic or organic oxy acids of sulfur which contain the RSO2(OH) radical.
The infusion of leaves of CAMELLIA SINENSIS (formerly Thea sinensis) as a beverage, the familiar Asian tea, which contains CATECHIN (especially epigallocatechin gallate) and CAFFEINE.

Procyanidin oligomers selectively and intensively promote proliferation of mouse hair epithelial cells in vitro and activate hair follicle growth in vivo. (1/371)

We have previously reported that proanthocyanidins extracted from grape seeds possess growth-promoting activity toward murine hair epithelial cells in vitro and stimulate anagen induction in hair cycle progression in vivo. This report constitutes a comparison of the growth-promoting activity of procyanidin oligomers and the target cells of procyanidins in the skin. Results show that procyanidin dimer and trimer exhibit higher growth-promoting activity than the monomer. The maximum growth-promoting activity for hair epithelial cells with procyanidin B-2, an epicatechin dimer, reached about 300% (30 microM) relative to controls (= 100%) in a 5 d culture. Optimum concentration of procyanidin C-1, an epicatechin trimer, was lower than that of procyanidin B-2; the maximum growth-promoting activity of procyanidin C-1 was about 220% (3 microM). No other flavonoid compounds examined exhibit higher proliferative activities than the procyanidins. In skin constituent cells, only epithelial cells such as hair keratinocytes or epidermal keratinocytes respond to procyanidin oligomers. Topical application of 1% procyanidin oligomers on shaven C3H mice in the telogen phase led to significant hair regeneration [procyanidin B-2, 69.6% +/- 21.8% (mean +/- SD); procyanidin B-3, 80.9% +/- 13.0%; procyanidin C-1, 78.3% +/- 7.6%] on the basis of the shaven area; application of vehicle only led to regeneration of 41.7% (SD = 16.3%). In this paper, we demonstrate the hair-growing activity of procyanidin oligomers both in vitro and in vivo, and their potential for use as agents to induce hair growth.  (+info)

Anti-tumor-promoting activity of a polyphenolic fraction isolated from grape seeds in the mouse skin two-stage initiation-promotion protocol and identification of procyanidin B5-3'-gallate as the most effective antioxidant constituent. (2/371)

Procyanidins present in grape seeds are known to exert anti-inflammatory, anti-arthritic and anti-allergic activities, prevent skin aging, scavenge oxygen free radicals and inhibit UV radiation-induced peroxidation activity. Since most of these events are associated with the tumor promotion stage of carcinogenesis, these studies suggest that grape seed polyphenols and the procyanidins present therein could be anticarcinogenic and/or anti-tumor-promoting agents. Therefore, we assessed the anti-tumor-promoting effect of a polyphenolic fraction isolated from grape seeds (GSP) employing the 7,12-dimethylbenz[a]anthracene (DMBA)-initiated and 12-O-tetradecanoylphorbol 13-acetate (TPA)-promoted SENCAR mouse skin two-stage carcinogenesis protocol as a model system. Following tumor initiation with DMBA, topical application of GSP at doses of 0.5 and 1.5 mg/mouse/application to the dorsal initiated mouse skin resulted in a highly significant inhibition of TPA tumor promotion. The observed anti-tumor-promoting effects of GSP were dose dependent and were evident in terms of a reduction in tumor incidence (35 and 60% inhibition), tumor multiplicity (61 and 83% inhibition) and tumor volume (67 and 87% inhibition) at both 0.5 and 1.5 mg GSP, respectively. Based on these results, we directed our efforts to separate and identify the individual polyphenols present in GSP and assess their antioxidant activity in terms of inhibition of epidermal lipid peroxidation. Employing HPLC followed by comparison with authentic standards for retention times in HPLC profiles, physiochemical properties and spectral analysis, nine individual polyphenols were identified as catechin, epicatechin, procyanidins B1-B5 and C1 and procyanidin B5-3'-gallate. Five of these individual polyphenols with evident structural differences, namely catechin, procyanidin B2, procyanidin B5, procyanidin C1 and procyanidin B5-3'-gallate, were assessed for antioxidant activity. All of them significantly inhibited epidermal lipid peroxidation, albeit to different levels. A structure-activity relationship study showed that with an increase in the degree of polymerization in polyphenol structure, the inhibitory potential towards lipid peroxidation increased. In addition, the position of linkage between inter-flavan units also influences lipid peroxidation activity; procyanidin isomers with a 4-6 linkage showed stronger inhibitory activity than isomers with a 4-8 linkage. A sharp increase in the inhibition of epidermal lipid peroxidation was also evident when a gallate group was linked at the 3'-hydroxy position of a procyanidin dimer. Procyanidin B5-3'-gallate showed the most potent antioxidant activity with an IC(50) of 20 microM in an epidermal lipid peroxidation assay. Taken together, for the first time these results show that grape seed polyphenols possess high anti-tumor-promoting activity due to the strong antioxidant effect of procyanidins present therein. In summary, grape seed polyphenols in general, and procyanidin B5-3'-gallate in particular, should be studied in more detail to be developed as cancer chemopreventive and/or anticarcinogenic agents.  (+info)

Protection against peroxynitrite by cocoa polyphenol oligomers. (3/371)

Flavonoids, natural plant constituents, protect against peroxynitrite and can thereby play a role in defense against this mediator of inflammation. Procyanidin oligomers of different size (monomer through nonamer), isolated from the seeds of Theobroma cacao, were examined for their ability to protect against peroxynitrite-dependent oxidation of dihydrorhodamine 123 and nitration of tyrosine. By molarity, oligomers were more effective than the monomeric epicatechin; the tetramer was particularly efficient at protecting against oxidation and nitration reactions. These results suggest that epicatechin oligomers found in cocoa powder and chocolate may be a potent dietary source for defense against peroxynitrite.  (+info)

Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. (4/371)

Considerable recent research has explored therapeutic applications of oligomeric proanthocyanidin complexes (OPCs), naturally occurring plant metabolites widely available in fruits, vegetables, nuts, seeds, flowers, and bark. OPCs are primarily known for their antioxidant activity. However, these compounds have also been reported to demonstrate antibacterial, antiviral, anticarcinogenic, anti-inflammatory, anti-allergic, and vasodilatory actions. In addition, they have been found to inhibit lipid peroxidation, platelet aggregation, capillary permeability and fragility, and to affect enzyme systems including phospholipase A2, cyclooxygenase, and lipoxygenase. Based on these reported findings, OPCs may be a useful component in the treatment of a number of conditions.  (+info)

Procyanidin content and variation in some commonly consumed foods. (5/371)

Procyanidins are a subclass of flavonoids found in commonly consumed foods that have attracted increasing attention due to their potential health benefits. However, little is known regarding their dietary intake levels because detailed quantitative information on the procyanidin profiles present in many food products is lacking. Therefore, the procyanidin content of red wine, chocolate, cranberry juice and four varieties of apples has been determined. On average, chocolate and apples contained the largest procyanidin content per serving (164.7 and 147.1 mg, respectively) compared with red wine and cranberry juice (22.0 and 31.9 mg, respectively). However, the procyanidin content varied greatly between apple samples (12.3-252.4 mg/serving) with the highest amounts on average observed for the Red Delicious (207.7 mg/serving) and Granny Smith (183.3 mg/serving) varieties and the lowest amounts in the Golden Delicious (92.5 mg/serving) and McIntosh (105.0 mg/serving) varieties. The compositional data reported herein are important for the initial understanding of which foods contribute most to the dietary intake of procyanidins and may be used to compile a database necessary to infer epidemiological relationships to health and disease.  (+info)

Cocoa procyanidins and human cytokine transcription and secretion. (6/371)

We examined whether cocoa, in its isolated procyanidin fractions (monomer through decamer), would modulate cytokine production at the levels of transcription and protein secretion in both resting and phytohemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMC). In resting cells, interleukin (IL)-1beta and IL-4 gene expression from cocoa-treated cells varied markedly among the subjects tested. However, at the protein level, the larger fractions (pentamer through decamer) stimulated a dramatic increase in IL-1beta concentration (up to ninefold) with increasing degree of polymerization. Similarly, these larger fractions augmented IL-4 concentration by as much as 2 pg/ml, whereas the control displayed levels nearly undetectable. In the presence of PHA, gene expression also seemed to be most affected by the larger procyanidin fractions. The pentameric through decameric fractions increased IL-1 beta expression by 7-19% compared with PHA control, whereas the hexameric through decameric fractions significantly inhibited PHA-induced IL-4 transcription in the range of 71-86%. This observation at the transcription level for IL-1 beta was reflected at the protein level in PHA-stimulated PBMC. Significant reductions in mitogen-induced IL-4 production were also seen at the protein level with the hexamer, heptamer and octamer. Individual oligomeric cocoa fractions were unstimulatory for IL-2 in resting PBMC. However, when induced with PHA, the pentamer, hexamer and heptamer fractions caused a 61-73% inhibition in IL-2 gene expression. This study offers additional data for the consideration of the health benefits of dietary polyphenols from a wide variety of foods, including those benefits associated specifically with cocoa and chocolate consumption.  (+info)

Reactions of peroxynitrite with cocoa procyanidin oligomers. (7/371)

Peroxynitrite is a mediator molecule in inflammation, and its biological properties are being studied extensively. Flavonoids, which are natural plant constituents, protect against peroxynitrite and thereby could play an anti-inflammatory role. Procyanidin oligomers of different sizes (monomer through nonamer), isolated from the seeds of Theobroma cacao, were recently examined for their ability to protect against peroxynitrite-dependent oxidation of dihydrorhodamine 123 and nitration of tyrosine and were found to be effective in attenuating these reactions. The tetramer was particularly efficient at protecting against oxidation and nitration reactions. Epicatechin oligomers found in cocoa powder and chocolate may be a potent dietary source for defense against peroxynitrite.  (+info)

Effects of cocoa extracts on endothelium-dependent relaxation. (8/371)

The aim of this study was to examine the effects of procyanidins derived from cocoa on vascular smooth muscle. Two hypotheses were tested: 1) extracts of cocoa, which are rich in procyanidins, cause endothelium-dependent relaxation (EDR), and 2) extracts of cocoa activate endothelial nitric oxide synthase (NOS). The experiments were carried out on aortic rings obtained from New Zealand White rabbits. The polymeric procyanidins (tetramer through decamer of catechin) caused an EDR. In addition, the Ca(2+)-dependent NOS activity, measured by the L-arginine to L-citrulline conversion assay, was significantly increased in aortic endothelial cells exposed to polymeric procyanidins, whereas monomeric compounds had no such effect. These findings demonstrate that polymeric procyanidins cause an EDR that is mediated by activation of NOS.  (+info)

Proanthocyanidins are a type of polyphenolic compound that are found in various plants, including fruits, vegetables, and bark. They are also known as condensed tannins or oligomeric procyanidins (OPCs). These compounds are characterized by their ability to form complex structures through the linkage of flavan-3-ol units.

Proanthocyanidins have been studied for their potential health benefits, which may include antioxidant, anti-inflammatory, and cardiovascular protective effects. They have also been shown to have a positive impact on collagen stability, which may contribute to their potential role in promoting skin and joint health.

Foods that are rich in proanthocyanidins include grapes (and red wine), berries, apples, cocoa, and green tea. These compounds can be difficult for the body to absorb, but supplements containing standardized extracts of proanthocyanidins are also available.

It's important to note that while proanthocyanidins have shown promise in laboratory and animal studies, more research is needed to fully understand their potential health benefits and safety profile in humans. As with any supplement, it's always a good idea to talk to your healthcare provider before starting to take proanthocyanidins.

Grape seed extract is not a medical term, but I can provide you with a general description and uses based on scientific and medical understanding.

Grape seed extract (GSE) is a dietary supplement derived from the ground-up seeds of grapes. It contains several bioactive compounds, including proanthocyanidins, which are potent antioxidants. GSE has been studied for its potential health benefits, such as:

1. Anti-inflammatory effects: GSE may help reduce inflammation by inhibiting the production of certain inflammatory molecules.
2. Cardiovascular health: Some research suggests that GSE could improve cardiovascular health by reducing blood pressure, increasing blood flow, and preventing platelet aggregation.
3. Antioxidant properties: The high antioxidant content in GSE helps protect cells from damage caused by free radicals.
4. Skin health: Topical application of GSE has been shown to improve skin hydration, elasticity, and reduce the appearance of wrinkles.
5. Neuroprotection: Preclinical studies indicate that GSE may have neuroprotective effects, potentially helping protect against age-related cognitive decline and neurodegenerative diseases like Alzheimer's.

However, it is essential to note that while some research shows promising results, more high-quality clinical trials are needed to confirm these potential health benefits and establish appropriate dosages. Always consult a healthcare professional before starting any new supplement regimen.

"Vaccinium macrocarpon" is the scientific name for the American cranberry, a type of evergreen shrub that produces berries which are commonly used in food and also have potential health benefits. The active ingredients in cranberries, including proanthocyanidins, are thought to help prevent urinary tract infections by preventing bacteria from adhering to the walls of the urinary tract. However, it is important to note that consuming cranberry products should not be considered a substitute for medical treatment for UTIs or any other health conditions.

"Diospyros" is a genus of evergreen or deciduous trees and shrubs, belonging to the family Ebenaceae. It includes several well-known species such as the persimmon (D. kaki) and ebony (D. ebenum). The name "Diospyros" comes from the Greek words "dios" meaning Zeus or god, and "pyros" meaning wheat, which may refer to the edible fruit of some species.

The trees in this genus are known for their hard, dense wood that is resistant to decay and insect attack, making them valuable for furniture-making, carving, and other woodworking applications. The fruit of some species, such as persimmon, are also eaten and valued for their high nutritional content.

It's worth noting that "Diospyros" is a scientific name used in the field of botany, and may not be commonly used in medical contexts unless referring to potential medicinal properties of plants in this genus.

"Vitis" is a genus name and it refers to a group of flowering plants in the grape family, Vitaceae. This genus includes over 70 species of grapes that are native to the Northern Hemisphere, particularly in North America and Asia. The most commonly cultivated species is "Vitis vinifera," which is the source of most of the world's table and wine grapes.

Therefore, a medical definition of 'Vitis' may not be directly applicable as it is more commonly used in botany and agriculture rather than medicine. However, some compounds derived from Vitis species have been studied for their potential medicinal properties, such as resveratrol found in the skin of red grapes, which has been investigated for its anti-inflammatory, antioxidant, and cardioprotective effects.

Anthocyanins are a type of plant pigment that belong to the flavonoid group. They are responsible for providing colors ranging from red, purple, and blue to black in various fruits, vegetables, flowers, and leaves. Anthocyanins have been studied extensively due to their potential health benefits, which include antioxidant, anti-inflammatory, and anti-cancer properties. They also play a role in protecting plants from environmental stressors such as UV radiation, pathogens, and extreme temperatures. Chemically, anthocyanins are water-soluble compounds that can form complex structures with other molecules, leading to variations in their color expression depending on pH levels.

Tannins, also known as tannic acid or gallotannins, are a type of polyphenolic biomolecule found in plants. They are most commonly known for their ability to bind to proteins and other organic compounds, forming insoluble complexes. This property is what gives tannins their characteristic astringent taste and is also the basis for their use in traditional medicine and industry.

In the context of human health, tannins have been studied for their potential beneficial effects on various physiological processes, such as antioxidant activity, anti-inflammatory effects, and inhibition of enzymes involved in cancer development. However, excessive consumption of tannins can also have negative health effects, including stomach irritation, nausea, and liver damage.

Tannins are found in a wide variety of plants, including fruits, vegetables, grains, nuts, bark, leaves, and roots. They are particularly abundant in certain types of food and beverages, such as red wine, tea, coffee, chocolate, and some herbs and spices. In the medical field, tannins have been used topically for their astringent properties to treat wounds, burns, and skin irritations. However, it is important to note that the evidence supporting the health benefits of tannins is still limited and more research is needed to fully understand their effects on human health.

A plant extract is a preparation containing chemical constituents that have been extracted from a plant using a solvent. The resulting extract may contain a single compound or a mixture of several compounds, depending on the extraction process and the specific plant material used. These extracts are often used in various industries including pharmaceuticals, nutraceuticals, cosmetics, and food and beverage, due to their potential therapeutic or beneficial properties. The composition of plant extracts can vary widely, and it is important to ensure their quality, safety, and efficacy before use in any application.

Polyphenols are a type of phytochemical, which are naturally occurring compounds found in plant-based foods. They contain multiple phenol units and can be classified into several subgroups, including flavonoids, stilbenes, tannins, and lignans. These compounds have been studied for their potential health benefits due to their antioxidant, anti-inflammatory, and immune-modulating properties. They are found in a wide variety of foods such as fruits, vegetables, tea, wine, chocolate, and cereals.

Flavonoids are a type of plant compounds with antioxidant properties that are beneficial to health. They are found in various fruits, vegetables, grains, and wine. Flavonoids have been studied for their potential to prevent chronic diseases such as heart disease and cancer due to their ability to reduce inflammation and oxidative stress.

There are several subclasses of flavonoids, including:

1. Flavanols: Found in tea, chocolate, grapes, and berries. They have been shown to improve blood flow and lower blood pressure.
2. Flavones: Found in parsley, celery, and citrus fruits. They have anti-inflammatory and antioxidant properties.
3. Flavanonols: Found in citrus fruits, onions, and tea. They have been shown to improve blood flow and reduce inflammation.
4. Isoflavones: Found in soybeans and legumes. They have estrogen-like effects and may help prevent hormone-related cancers.
5. Anthocyanidins: Found in berries, grapes, and other fruits. They have antioxidant properties and may help improve vision and memory.

It is important to note that while flavonoids have potential health benefits, they should not be used as a substitute for medical treatment or a healthy lifestyle. It is always best to consult with a healthcare professional before starting any new supplement regimen.

Flavonols are a type of flavonoid, which is a class of plant and fungal metabolites. They are characterized by the presence of a 3-hydroxyflavone skeleton. Flavonols are found in a variety of plants and are known for their antioxidant properties. Some common dietary sources of flavonols include onions, kale, broccoli, apples, tea, and red wine. They have been studied for their potential health benefits, including reducing the risk of chronic diseases such as cancer and cardiovascular disease. Flavonols are also known to have anti-inflammatory, neuroprotective, and antimicrobial properties.

In medical terms, "seeds" are often referred to as a small amount of a substance, such as a radioactive material or drug, that is inserted into a tissue or placed inside a capsule for the purpose of treating a medical condition. This can include procedures like brachytherapy, where seeds containing radioactive materials are used in the treatment of cancer to kill cancer cells and shrink tumors. Similarly, in some forms of drug delivery, seeds containing medication can be used to gradually release the drug into the body over an extended period of time.

It's important to note that "seeds" have different meanings and applications depending on the medical context. In other cases, "seeds" may simply refer to small particles or structures found in the body, such as those present in the eye's retina.

Phenols, also known as phenolic acids or phenol derivatives, are a class of chemical compounds consisting of a hydroxyl group (-OH) attached to an aromatic hydrocarbon ring. In the context of medicine and biology, phenols are often referred to as a type of antioxidant that can be found in various foods and plants.

Phenols have the ability to neutralize free radicals, which are unstable molecules that can cause damage to cells and contribute to the development of chronic diseases such as cancer, heart disease, and neurodegenerative disorders. Some common examples of phenolic compounds include gallic acid, caffeic acid, ferulic acid, and ellagic acid, among many others.

Phenols can also have various pharmacological activities, including anti-inflammatory, antimicrobial, and analgesic effects. However, some phenolic compounds can also be toxic or irritating to the body in high concentrations, so their use as therapeutic agents must be carefully monitored and controlled.

"Viburnum" is not a medical term, but a genus of shrubs and small trees that belong to the Adoxaceae family. These plants are commonly known as "viburnums," and they have various uses in horticulture due to their attractive flowers, fruits, and foliage.

While there may be some medicinal uses for certain species of Viburnum, it is not a term that would typically appear in a medical context or definition. If you're looking for information about the medicinal properties of specific plants within the Viburnum genus, I would recommend consulting a reliable source on herbal medicine or speaking with a healthcare professional who has expertise in this area.

"Polygonum" is a genus of plants, also known as "knotweed," that belongs to the family Polygonaceae. It includes various species, some of which have been used in traditional medicine. However, it does not have a specific medical definition as it refers to a group of plants and not a particular medical condition or treatment. Some species of Polygonum have been studied for their potential medicinal properties, such as anti-inflammatory, antioxidant, and antimicrobial effects. But, it is essential to note that further research is required to establish their safety and efficacy in clinical settings.

A catechin is a type of plant phenol and antioxidant found in various foods and beverages, such as tea, cocoa, and certain fruits and vegetables. Chemically, catechins are flavan-3-ols, which are a subclass of flavonoids. They have several potential health benefits, including reducing the risk of cardiovascular disease, cancer, and neurodegenerative disorders.

Catechins are known to have anti-inflammatory, antimutagenic, and antidiabetic properties. They can also help improve oral health by inhibiting the growth of harmful bacteria in the mouth. The most well-known catechin is epigallocatechin gallate (EGCG), which is found in high concentrations in green tea and has been extensively studied for its potential health benefits.

In summary, a catechin is a type of antioxidant compound found in various plant-based foods and beverages that may have several health benefits, including reducing the risk of chronic diseases and improving oral health.

"Pelargonium" is not a term that has a medical definition. It is the name of a genus of flowering plants, commonly known as geraniums, which are often used in horticulture but do not have direct relevance to medical terminology or practice.

Biflavonoids are a type of flavonoid, which are plant-based compounds with antioxidant properties. Biflavonoids are unique because they consist of two flavonoid molecules joined together. They can be found in various plants, including fruits, vegetables, and herbs. Some research suggests that biflavonoids may have potential health benefits, such as reducing inflammation and protecting against oxidative stress. However, more research is needed to confirm these effects and determine the optimal dosages for human consumption.

I'm sorry for any confusion, but "Plant Bark" is not a term with a specific medical definition. In general, the bark refers to the outermost covering of a tree or other plant, which serves as protection and provides a barrier against external threats. It is composed of layers including the inner bark (phloem), which transports nutrients throughout the plant, and the outer bark (periderm), which is made up of dead cells that form a protective layer.

While some plants or plant parts do have medicinal properties and are used in various forms of traditional or alternative medicine, "Plant Bark" by itself does not have any specific medical connotations. If you're referring to a specific type of plant bark with potential medicinal uses, please provide more details so I can give a more accurate response.

Bombacaceae is a family of flowering plants that includes trees, shrubs, and herbs. It was previously recognized as a distinct family, but recent classifications have merged it into the Malvaceae family. Plants in this group are characterized by their large, showy flowers and often contain a great deal of mucilage. Some well-known members of this group include the baobab tree, the kapok tree, and the silk-cotton tree.

Ephedra sinica, also known as Ma Huang, is a plant that has been used in traditional Chinese medicine for thousands of years. It contains several alkaloids, including ephedrine and pseudoephedrine, which have stimulant effects on the central nervous system and cardiovascular system.

Ephedra sinica has been used to treat various medical conditions such as asthma, bronchitis, and nasal congestion. However, its use as a dietary supplement or weight loss aid has been controversial due to concerns about its safety. The U.S. Food and Drug Administration (FDA) banned the sale of dietary supplements containing ephedra in 2004 due to the risk of serious adverse effects, including heart attack, stroke, and death.

It is important to note that Ephedra sinica should only be used under the supervision of a qualified healthcare professional, as it can interact with other medications and have potentially dangerous side effects.

"Ribes" is a botanical term that refers to a genus of shrubs in the family Grossulariaceae, which includes plants commonly known as gooseberries and currants. These plants are native to the temperate regions of the Northern Hemisphere and are widely cultivated for their edible fruits.

However, I believe you may be looking for a medical term related to "ribes." There is no specific medical term or condition directly related to "ribes" in the context of human health or disease. If you have any further questions or need clarification on a different medical term, please let me know!

I'm sorry for any confusion, but "Photinia" is not a medical term. It is a genus of shrubs and small trees in the rose family, Rosaceae. The most commonly cultivated species is Photinia x fraseri, also known as Fraser photinia or Red Robin, which is often used in landscaping due to its attractive, glossy green leaves and clusters of white flowers followed by bright red berries.

If you have any medical concerns or questions, I would be happy to try to help with those.

I'm sorry for any confusion, but "fruit" is not a medical term per se. It is a common term used to describe the part of a plant that develops from the ovary after flowering and contains seeds. However, in a nutritional or dietary context, "fruits" are often referred to as foods that are typically sweet and juicy, and come from plants' flowers. They are rich in fiber, vitamins, and minerals, making them an essential part of a healthy diet. But in a strict medical sense, there isn't a specific definition for "fruit."

"Food analysis" is not a medical term per se, but it falls under the broader field of food science and nutrition. Food analysis refers to the laboratory methods and techniques used to determine the composition and quality of food products. This can include testing for nutrients (such as proteins, fats, carbohydrates, vitamins, and minerals), contaminants (like heavy metals, pesticides, or allergens), and other components that may affect the safety, quality, or authenticity of food.

The results of food analysis can be used to ensure compliance with regulatory standards, develop new food products, assess the nutritional value of diets, investigate food-borne illnesses, and monitor trends in food consumption. While not a medical definition, food analysis is an important tool for promoting public health and preventing diet-related diseases.

'Wine' is not typically defined in medical terms, but it is an alcoholic beverage made from the fermentation of grape juice. It contains ethanol and can have varying levels of other compounds depending on the type of grape used, the region where it was produced, and the method of fermentation.

In a medical context, wine might be referred to in terms of its potential health effects, which can vary. Moderate consumption of wine, particularly red wine, has been associated with certain health benefits, such as improved cardiovascular health. However, heavy or excessive drinking can lead to numerous health problems, including addiction, liver disease, heart disease, and an increased risk of various types of cancer.

It's important to note that while moderate consumption may have some health benefits, the potential risks of alcohol consumption generally outweigh the benefits for many people. Therefore, it's recommended that individuals who do not currently drink alcohol should not start drinking for health benefits. Those who choose to drink should do so in moderation, defined as up to one drink per day for women and up to two drinks per day for men.

Antioxidants are substances that can prevent or slow damage to cells caused by free radicals, which are unstable molecules that the body produces as a reaction to environmental and other pressures. Antioxidants are able to neutralize free radicals by donating an electron to them, thus stabilizing them and preventing them from causing further damage to the cells.

Antioxidants can be found in a variety of foods, including fruits, vegetables, nuts, and grains. Some common antioxidants include vitamins C and E, beta-carotene, and selenium. Antioxidants are also available as dietary supplements.

In addition to their role in protecting cells from damage, antioxidants have been studied for their potential to prevent or treat a number of health conditions, including cancer, heart disease, and age-related macular degeneration. However, more research is needed to fully understand the potential benefits and risks of using antioxidant supplements.

I believe there may be a slight misunderstanding in your question. "Plant leaves" are not a medical term, but rather a general biological term referring to a specific organ found in plants.

Leaves are organs that are typically flat and broad, and they are the primary site of photosynthesis in most plants. They are usually green due to the presence of chlorophyll, which is essential for capturing sunlight and converting it into chemical energy through photosynthesis.

While leaves do not have a direct medical definition, understanding their structure and function can be important in various medical fields, such as pharmacognosy (the study of medicinal plants) or environmental health. For example, certain plant leaves may contain bioactive compounds that have therapeutic potential, while others may produce allergens or toxins that can impact human health.

Phytotherapy is the use of extracts of natural origin, especially plants or plant parts, for therapeutic purposes. It is also known as herbal medicine and is a traditional practice in many cultures. The active compounds in these plant extracts are believed to have various medicinal properties, such as anti-inflammatory, analgesic, or sedative effects. Practitioners of phytotherapy may use the whole plant, dried parts, or concentrated extracts to prepare teas, capsules, tinctures, or ointments for therapeutic use. It is important to note that the effectiveness and safety of phytotherapy are not always supported by scientific evidence, and it should be used with caution and preferably under the guidance of a healthcare professional.

I am not a medical expert, but I can provide some information that may be helpful. "Picrates" is not a term commonly used in medical definitions. Instead, it is a term used in chemistry to refer to salts of picric acid (2,4,6-trinitrophenol), which was once used as a yellow dye and explosive.

Picric acid has been used historically in some medical applications, such as a component in certain topical antiseptics and in histological staining procedures. However, its use in modern medicine is quite limited due to its high sensitivity to impact, heat, and friction, which makes it potentially dangerous to handle.

Therefore, it's important to note that "picrates" is not a medical term per se but rather a chemical one, and any medical application of picric acid or its salts would be highly specialized and unlikely to be encountered in most healthcare settings.

I'm sorry for any confusion, but "sulfonic acids" are not a medical term. They are a type of compound in chemistry, specifically strong organic acids that contain the functional group -SO3H. Sulfonic acids are widely used in industry and research, including the production of detergents, dyes, and pharmaceuticals.

If you have any questions related to medical terminology or concepts, please don't hesitate to ask!

I'm sorry for any confusion, but "Tea" is not a medical term. It generally refers to a hot beverage made by infusing the leaves of the tea plant (Camellia sinensis) in hot water. There are various types of tea including black, green, white, oolong, and herbal teas, but these are not medical terms. If you have any medical concerns or questions, I'd be happy to try to help if I can, but it would be helpful if you could provide more context or clarify what you're asking about.

It can also be used to titrate proanthocyanidins. Proanthocyanidins from field beans (Vicia faba) or barley have been estimated ... Tandem mass spectrometry can be used to sequence proanthocyanidins. Oligomeric proanthocyanidins (OPC) strictly refer to dimer ... A type proanthocyanidin B type proanthocyanidin Tannin Polyphenol Phenolic compounds in wine Schwitters, Bert (1995). OPC in ... Thus a 100 mg serving would contain 65 to 75 mg of proanthocyanidins (procyanidins). Proanthocyanidin glycosides can be ...
... may refer to: Procyanidin B3, a catechin dimer Prodelphinidin B3, a gallocatechin-catechin dimer This set ...
B type proanthocyanidins are a specific type of proanthocyanidin, which are a class of flavanoids. They are oligomers of flavan ... Dimeric proanthocyanidins can also be synthesized with procyanidin-rich grape seed extracts reacted with flavan-3-ols under ...
A type proanthocyanidins are a specific type of proanthocyanidins, which are a class of flavonoid. Proanthocyanidins fall under ... A-type proanthocyanidin glycosides can be isolated from cocoa liquor. Procyanidin A1 is an epicatechin-(2β→7,4β→8)-catechin ... Proanthocyanidins were first popularized by French scientist Jacques Masquelier. A-type linkage is a less common feature in ... Other A-type proanthocyanidins can be found in cranberries, cinnamon, peanut skins and Geranium niveum. B-type procyanidins ( ...
... is a B type proanthocyanidin trimer, a type of condensed tannin. Procyanidin C2 is found in grape seeds (Vitis ... Brandon MJ, Foo LY, Porter LJ, Meredith P (1980). "Proanthocyanidins of barley and sorghum; composition as a function of ... ISBN 978-0-471-95893-2. Thompson RS, Jacques D, Haslam E, Tanner RJ (1972). "Plant proanthocyanidins. Part I. Introduction; the ... The contents in barley grain of trimeric proanthocyanidins, including procyanidin C2, range from 53 to 151 μg catechin ...
Porter, Lawrence J. (1988-01-01). "Flavans and proanthocyanidins". In Harborne, J. B. (ed.). The Flavonoids. Springer US. pp. ...
Proanthocyanidin-A-2 on liberherbarum.com Facino, R. Maffei; Carini, M.; Brambilla, A.; Bombardelli, E.; Morazzoni, P. (1996 ... Hongxiang Lou; Yamazaku Y.; Sasaku T.; Uchida M.; Tanaka H.; Oka S. (1999). "A-type proanthocyanidins from peanut skins". ... Procyanidin A2 is an A type proanthocyanidin. It is found in avocado, chestnut, cranberry juice concentrate, lychee fruit ... Koerner Jayma, Hsu Victor, Lee Jungmin, Kennedy, James (2009). "Determination of Proanthocyanidin A2 Content in Phenolic ...
The extract contains proanthocyanidins. Grape seed extract quality is measured by the content of procyanidins which are formed ... from proanthocyanidins. Generally, grape seed extract quality contains 95% procyanidins, but potency varies among products. ...
... is an A type proanthocyanidin dimer. It is an epicatechin-(2β→7,4β→8)-catechin dimer found in Rhododendron ... Hongxiang Lou; Yamazaku Y.; Sasaku T.; Uchida M.; Tanaka H.; Oka S. (1999). "A-type proanthocyanidins from peanut skins". ... doi:10.1016/S0031-9422(98)00736-5. Lin, Lie-Chwen; Kuo, Yuh-Chi; Chou, Cheng-Jen (2002). "Immunomodulatory Proanthocyanidins ... "Immunomodulatory effects of proanthocyanidin A-1 derived in vitro from Rhododendron spiciferum". Fitoterapia. 81 (2): 108-14. ...
A type proanthocyanidin B type proanthocyanidin Procyanidin C1 Procyanidin C2 Tannin Polyphenol Phenolic compounds in wine ... USDA Database for the Proanthocyanidin Content of Selected Foods. PDF summary accessed from main USDA page here. Page accessed ... USDA Database for the Proanthocyanidin Content of Selected Foods (PDF). August 2004. Archived from the original (PDF) on 2010- ... 481-485 Kennedy, J. A.; Jones, G. P. (2001). "Analysis of Proanthocyanidin Cleavage Products Following Acid-Catalysis in the ...
Flavonoids: Iridoids and proanthocyanidins absent. Flavonols, kaempferol and/or quercetin present. Many of these plants are ...
Proanthocyanidins present (cyanidin and delphinidin). Flavonols present (kaempferol and quercetin). The fruits produce 2.5 - 5 ...
Souquet, Jean-Marc; Cheynier, Véronique; Brossaud, Franck; Moutounet, Michel (1996). "Polymeric proanthocyanidins from grape ...
They are called proanthocyanidins as they yield anthocyanidins when depolymerized under oxidative conditions. Different types ... Thioglycolysis can be used to study proanthocyanidins or the oxidation of condensed tannins. It is also used for lignin ... Phloroglucinolysis can be used for instance for proanthocyanidins characterisation in wine or in the grape seed and skin ... Acid butanol assy for proanthocyanidins. by Ann E. Hagermann, 2002 (article) Porter, Lawrence J.; Hrstich, Liana N.; Chana, ...
It is composed mostly of proanthocyanidins. Jack Masquelier is reported to have read the account of the explorer of Jacques ... Various sources were looked into by Masquelier and he found a suitable source in, and extracted proanthocyanidins from, the ...
Mouming Zhao; Bao Yang; Jinshui Wang; Yang Liu; Limei Yu; Yueming Jiang, 2007 Proanthocyanidin-B2 on fuzing.com Lin LC (2002 ... Procyanidin B2 is a B type proanthocyanidin. Its structure is (−)-Epicatechin-(4β→8)-(−)-epicatechin. Procyanidin B2 can be ... "Immunomodulatory Proanthocyanidins from Ecdysanthera u tilis". Journal of Natural Products. 65 (4): 505-508. doi:10.1021/ ... Phenolic content in wine Proanthocyanidin-B2 on liberherbarum.com Immunomodulatory and anticancer activities of flavonoids ...
Li HJ, Deinzer ML (February 2007). "Tandem mass spectrometry for sequencing proanthocyanidins". Analytical Chemistry. 79 (4): ...
They have been identified as proanthocyanidins in 1969. The thearubigins formation has been studied in an in vitro model in ... "Use of Porter's reagents for the characterisation of thearubigins and other non-proanthocyanidins". Journal of the Science of ... "Identification of the Thearubigins as Polymeric Proanthocyanidins". Nature. 221 (5182): 742-4. Bibcode:1969Natur.221..742B. doi ...
Proanthocyanidins are present in the testa of seeds. Nanakusa-no-sekku "Stellaria media". RHS. Retrieved 25 October 2020. Stace ... Bittrich, V.; Amaral, Maria Do Carmo E. (1991). "Proanthocyanidins in the testa of centrospermous seeds". Biochemical ...
Pentacyclic triterpenoids, flavonols, proanthocyanidins and tannins present. The plants are not cyanogenetic. Some species of ...
The species contains proanthocyanidin B2, proanthocyanidin A1 and proanthocyanidin A2. "World Checklist of Selected Plant ... Proanthocyanidins - a final frontier in flavonoid research? Richard A. Dixon, De-Yu Xie and Shashi B. Sharma, New Phytologist ( ...
Tanner GJ, Francki KT, Abrahams S, Watson JM, Larkin PJ, Ashton AR (2003). "Proanthocyanidin biosynthesis in plants. ...
Tanner GJ, Francki KT, Abrahams S, Watson JM, Larkin PJ, Ashton AR (August 2003). "Proanthocyanidin biosynthesis in plants. ... proanthocyanidins (apple, grape, cocoa), and quercetin (onion, tea, apples). Phenolic acid include caffeic acid Lignans are ... Proanthocyanidins are mostly polymeric units of catechin and epicatechin. Polyphenols often have functional groups beyond ... proanthocyanidins, and anthocyanins. Particularly abundant flavanoids in foods are catechin (tea, fruits), hesperetin (citrus ...
Proanthocyanidins and thearubigins are oligomeric flavan-3-ols. In contrast to many other flavonoids, flavan-3-ols do not ... proanthocyanidins, theaflavins, thearubigins. They play a part in plant defense and are present in the majority of plants. The ... proanthocyanidins) and higher order polymers (anthocyanidins). Flavan-3-ols possess two chiral carbons, meaning four ...
Oligomeric proanthocyanidins (OPC) can be obtained by the means of V. pahalae in vitro cell culture. Hawaiian Vaccinium USDA, ... "Isolation of oligomeric proanthocyanidins from flavonoid-producing cell cultures". In Vitro Cellular & Developmental Biology - ...
10: 70 1892 Antioxidant oligomeric proanthocyanidins from Cistus salvifolius. Fadi Qa'dan, Frank Petereit, Kenza Mansoor and ... Cistus salviifolius contains flavan-3ols, oligomeric proanthocyanidins and prodelphinidins such as epigallocatechin-3-O-(4- ...
Flavanols are further classified as catechins, epicatechins, and proanthocyanidins. In total, between 50,000 and 130,000 ...
10.1080/14786410801940968 Oligomeric proanthocyanidins: naturally occurring O-heterocycles. Daneel Ferreira and Desmond Slade, ... The structural moieties constitute the proteracacinidin class of proanthocyanidins. Mesquitol-(5→8)-catechin atropisomers can ...
Hagerman, A.E.; Butler, L.G. (1981). "The Specificity of Proanthocyanidin-Protein Interactions". Journal of Biological ... Reduction in protein availability and The specificity of proanthocyanidin‑protein interactions. The former was the first ...
Maldonado, PD; Rivero-Cruz, I; Mata, R; Pedraza-Chaverrí, J (2005). "Antioxidant activity of A-type proanthocyanidins from ... new antiprotozoal A-type proanthocyanidins from Geranium niveum". Journal of Natural Products. 62 (5): 705-9. doi:10.1021/ ...
It can also be used to titrate proanthocyanidins. Proanthocyanidins from field beans (Vicia faba) or barley have been estimated ... Tandem mass spectrometry can be used to sequence proanthocyanidins. Oligomeric proanthocyanidins (OPC) strictly refer to dimer ... A type proanthocyanidin B type proanthocyanidin Tannin Polyphenol Phenolic compounds in wine Schwitters, Bert (1995). OPC in ... Thus a 100 mg serving would contain 65 to 75 mg of proanthocyanidins (procyanidins). Proanthocyanidin glycosides can be ...
In this study, we demonstrate an anti-virulence activity of a cranberry extract rich in proanthocyanidins (cerPAC) against P. ... Molecular docking studies suggest that cranberry-derived proanthocyanidin binds to QS transcriptional regulators, mainly ... Cranberry-derived proanthocyanidins impair virulence and inhibit quorum sensing of Pseudomonas aeruginosa. *Vimal B. Maisuria1 ... How to cite this article: Maisuria, V. B. et al. Cranberry-derived proanthocyanidins impair virulence and inhibit quorum ...
Proanthocyanidins, also known as OPCs (oligomeric proanthocyanidins) or condensed tannins, are a subgroup of the flavonoid ... who developed and later patented techniques for the extraction of proanthocyanidins from pine needles and grape seeds.. https ... oligomeric proanthocyanidins (OPCs) → ολιγομερείς προανθοκυανιδίνες on: 12 Jan, 2012, 16:13:40 ...
Especially, proanthocyanidins (ranging from dimers to decamers) have demonstrated potential interactions with biological ... and polymeric proanthocyanidins. The aim of this work is to compare the phenolic composition of Theobroma cacao and Vitis ... and its phenolic quantitation in order to evaluate the proanthocyanidin profile. The antioxidant capacity was measured by ... Peaks 2, 4-11, 13-17, 19-21, 23 and 25 were identified as proanthocyanidins and derivatives. ...
Proanthocyanidins are constructed from monomeric flavan-3-ols, which is considered one of the largest and most functional ... Proanthocyanidins play an important role in wine; with the capability to bind salivary proteins, these condensed tannins ... The final composition and concentration of proanthocyanidins can be further impacted by the time period and temperatures of the ... In grapes, the composition of proanthocyanidins varies according to the tissue type; the grape skins typically contain higher ...
... proanthocyanidin group (PCG), ischemia group (IG) and proanthocyanidin-treated group (PCT). Rats in CG and IG were fed standard ... We investigated the cardioprotective effect of proanthocyanidin.Material/Methods:Thirty-two Rattus Norvegicus rats were ... Proanthocyanidin may have a protective effect on myocardial ischemic injury. ... rat food and PCG and PCT were fed standard rat food plus proanthocyanidin (100 mg/kg/day twice a day by oral gavage) for 3 ...
Dietary lignan and proanthocyanidin consumption and colorectal adenoma recurrence in the Polyp Prevention Trial. Title. Dietary ... Dietary lignan and proanthocyanidin consumption and colorectal adenoma recurrence in the Polyp Prevention Trial ... lignan and proanthocyanidin consumption and colorectal adenoma recurrence in the Polyp Prevention Trial. ...
Lee J, Kim YI, Kim Y, Choi M, Min S, Joo YH, Yim S and Chung N: Grape seed proanthocyanidin inhibits inflammatory responses in ... Grape seed proanthocyanidin inhibits inflammatory responses in hepatic stellate cells by modulating the MAPK, Akt and NF-κB ... Grape seed proanthocyanidin (GSP), referred to as condensed tannins, includes a high content of flavonoids. The free radical- ... Lee, J., Kim, Y. I., Kim, Y., Choi, M., Min, S., Joo, Y. H., Yim, S., Chung, N.Grape seed proanthocyanidin inhibits ...
Discover the power of Oligomeric Proanthocyanidins - a natural antioxidant and powerful free radical scavenger with amazing ... Oligomeric Proanthocyanidins. ( OPCs ). Oligomeric proanthocyanidins (OPCs) are plant based flavonol compounds that are ... The oligomeric proanthocyanidins, as a group of distinct compounds are named after the flavonoid compounds they are derived ... Oligomeric proanthocyanidins (OPCs) used as supplements are taken from two principal sources. One is a pine bark extract known ...
absorption, anthocyanins, cancer, flavonols, inflammation, pheno\s, proanthocyanidins, urinary tract infections What nutrients ...
Proanthocyanidins belong to a class of polyphenolic compounds called flavonoids and they have been reported to exhibit ... Investigation of aqueous soluble proanthocyanidins in the inflorescence of Cocos nucifera L.. J Pharmacogn Phytochem 2016;5(1): ... Proanthocyanidins belong to a class of polyphenolic compounds called flavonoids and they have been reported to exhibit ... In addition, AQSPA was subjected to 13C NMR spectroscopy to study the occurrence of proanthocyanidins in this fraction. The ...
Proanthocyanidins Return to Ingredient Cross Reference
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... and Supplier of Proanthocyanidin in Zhejiang , China. Contact us Now to know more about Proanthocyanidin ... Proanthocyanidin (PA or PAC), also known as procyanidin, oligomeric proanthocyanidin (OPC), leukocyanidin, leucoanthocyanin and ... Proanthocyanidins have been sold as nutritional and therapeutic supplements in Europe since the 1980s, but their introduction ... It was Masquelier who first developed techniques for the extraction of proanthocyanidins from certain plant species. ...
... to proanthocyanidin (PAC), a plant-derived compound that may inhibit the progression of several other cancers. Using a series ... Proanthocyanidins are part of a larger group of compounds that have been demonstrated to have anti-proliferative and anti-tumor ... Grape seed proanthocyanidin (PAC) extract (Lot #3717HF7361) was obtained from GNC Preventive Nutrition® (Pittsburgh, PA). This ... Sano T, Oda E, Yamashita T, Naemura A, Ijiri Y, Yamakoshi J, Yamamota J: Anti-thrombotic effect of proanthocyanidin, a purified ...
Assessment of the dietary intake of total flavan-3-ols, monomeric flavan-3-ols, proanthocyanidins and theaflavins in the ... Therefore, in the present study, we assessed the habitual intake of flavan-3-ol monomers, proanthocyanidins (PA) and ... proanthocyanidins and theaflavins in the European Union. British Journal of Nutrition, 111 (08). pp. 1463-1473. ISSN 0007-1145 ...
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The proanthocyanidins in three foods (pinto beans, plums and cinnamon) were studied with electrospray ionization (ESI) mass ... The proanthocyanidins in three foods (pinto beans, plums and cinnamon) were studied with electrospray ionization (ESI) mass ... Proanthocyanidins with interestingly different A-type linkages were identified in plums and cinnamon. In efforts aimed at ... Home Published research Liquid chromatographic/electrospray ionization mass spectrometric studies of proanthocyanidins in foods ...
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  • Proanthocyanidins, also known as OPCs (oligomeric proanthocyanidins) or condensed tannins, are a subgroup of the flavonoid class of polyphenols. (translatum.gr)
  • Grape seed proanthocyanidin (GSP), referred to as condensed tannins, includes a high content of flavonoids. (spandidos-publications.com)
  • Another mechanism may involve suppression of Escherichia coli fimbriae by proanthocyanidins (tannins). (medscape.com)
  • Proanthocyanidins are constructed from monomeric flavan-3-ols, which is considered one of the largest and most functional subclass of flavonoids found in foods and beverages 2 . (ucdavis.edu)
  • Proanthocyanidins belong to a class of polyphenolic compounds called flavonoids and they have been reported to exhibit important pharmacological activities. (phytojournal.com)
  • Proanthocyanidins are a class of flavonoids gathering steam as dietary supplements among worldwide consumers on account of their substantial nutritional value and therapeutic benefits. (tmrblog.com)
  • CranRx contains a potent dose of researched cranberry fruit concentrate standardized to PACs (proanthocyanidins), the key flavonoids in cranberries. (naturesway.com)
  • Proanthocyanidins (PACs) are oligomeric flavan‐3‐ols found in fruits and botanicals that are used as ingredients in dietary supplements due to their putative health benefits. (researchgate.net)
  • In past research, this team identified plant-derived proanthocyanidins (PACs) as promising treatments for dental issues because these compounds can strengthen dentin, the layer of the tooth under the enamel. (acs.org)
  • Due to a significant increase in demand for proanthocyanidins as dietary supplements, the United States holds the largest share in the country. (techmisha.com)
  • Efforts of manufacturers to back nutritional benefit claims through in-vitro studies prove as a strong underpinning to the demand for proanthocyanidins as dietary supplements. (tmrblog.com)
  • Therefore, in the present study, we assessed the habitual intake of flavan-3-ol monomers, proanthocyanidins (PA) and theaflavins in the European Union (EU) and determined their main food sources using the EFSA (European Food Safety Authority) Comprehensive European Food Consumption Database. (reading.ac.uk)
  • This large and heterogeneous European study showed inverse associations between all individual flavan-3-ol monomers, proanthocyanidins with a low polymerization degree, and the flavonol myricetin and incident T2D. (nih.gov)
  • Proanthocyanidins were discovered in 1947 by Jacques Masquelier, who developed and patented techniques for the extraction of oligomeric proanthocyanidins from pine bark and grape seeds. (wikipedia.org)
  • An extract of maritime pine bark called Pycnogenol bears 65-75 percent proanthocyanidins (procyanidins). (wikipedia.org)
  • Oligomeric proanthocyanidins (OPCs) are plant based flavonol compounds that are commercially extracted from grape seeds or pine bark. (elmaskincare.com)
  • Taking grape seed extract or proanthocyanidin, a chemical in grape seeds, by mouth seems to reduce symptoms of CVI such as tired or heavy legs and pain. (medlineplus.gov)
  • Taking proanthocyanidin, a chemical found in grape seed extract, does not reduce breast tissue hardness, pain, or tenderness in people treated with radiation therapy for breast cancer. (medlineplus.gov)
  • Meanwhile, developing regions, notably Asia Pacific, may contribute sizeable shares of revenue to the global proanthocyanidins market. (tmrblog.com)
  • Proanthocyanidins, including the lesser bioactive and bioavailable polymers (four or more catechins), represent a group of condensed flavan-3-ols, such as procyanidins, prodelphinidins and propelargonidins. (wikipedia.org)
  • The most abundant ones were the caffeoylquinic acids and the proanthocyanidin oligomers and polymers. (lu.se)
  • Summary: The concentration of proanthocyanidins from twenty red wines from cv. (pucv.cl)
  • The protein precipitation assay gave the lowest concentration of proanthocyanidins in all of the red wines. (pucv.cl)
  • Analyses by UHPLC-MS detected quinic acid, chlorogenic acid isomers, proanthocyanidin dimers type B and C, catechin/epicatechin, orientin/isoorientin, isoorientin 2"- O -xyloside, vitexin/isovitexin, and rutin. (bvsalud.org)
  • This is because it is the richest known plant source of OPC (Oligomeric Proanthocyanidin) which helps eliminate toxins. (chinaqualitycrafts.com)
  • The interaction between A‐type interflavan bonds from cranberry proanthocyanidins (PAC) and surface virulence factors of extra‐intestinal pathogenic Escherichia coli (ExPEC) was studied. (researchgate.net)
  • Cranberry proanthocyanidins (PAC) contain unusual double A-type linkages, which are associated with strong interactions with surface virulence factors found on UTI-causing bacteria such as extra-intestinal pathogenic Escherichia coli (E. (researchgate.net)
  • Natural unprocessed cranberry juice contains anthocyanidins (eg, proanthocyanidin), which prevent Escherichia coli from attaching to the urinary tract wall. (msdmanuals.com)
  • In this study, we demonstrate an anti-virulence activity of a cranberry extract rich in proanthocyanidins (cerPAC) against P. aeruginosa in the model host Drosophila melanogaster and show this is mediated by QS interference. (nature.com)
  • One major effect of the oligomeric proanthocyanidins (OPCs) is that they inhibit the action of histamine and prevent it from inducing inflammation, swelling, and pain in the soft tissues of the body. (elmaskincare.com)
  • The primary purpose of this study was to investigate the response of human oral squamous cell carcinoma (OSCC) to proanthocyanidin (PAC), a plant-derived compound that may inhibit the progression of several other cancers. (biomedcentral.com)
  • Proanthocyanidins are a class of polyphenols found in many plants, such as cranberry, blueberry, and grape seeds. (wikipedia.org)
  • Gel permeation chromatography (GPC) analysis allows separation of monomers from larger proanthocyanidin molecules. (wikipedia.org)
  • Monomers of proanthocyanidins can be characterized by analysis with HPLC and mass spectrometry. (wikipedia.org)
  • With the capabilities of acting as antiatherosclerotic, immunologic, antimicrobial, and antiviral agents, as well as potent antioxidants, proanthocyanidins are being considered as potential therapeutics to alleviate various chronic diseases. (ucdavis.edu)
  • Furthermore, because of their anti-angiogenic, antimicrobial, and anticancer properties, proanthocyanidins are expected to rise in popularity in the pharmaceutical industry in the coming years. (techmisha.com)
  • Proanthocyanidins are under preliminary research for the potential to reduce the risk of urinary tract infections (UTIs) by consuming cranberries, grape seeds or red wine. (wikipedia.org)
  • grape seeds are a particularly rich source of proanthocyanidins in both quantity and variety ( 4 ). (spandidos-publications.com)
  • Proanthocyanidin concentrations were determined by a methylcellulose precipitation assay, a protein precipitation assay and two colourimetric methods (Bate-Smith and vanillin assay). (pucv.cl)
  • The four methodologies showed high repeatability but differed widely in proanthocyanidin concentrations. (pucv.cl)
  • DMACA is a dye that is particularly useful for localization of proanthocyanidin compounds in plant histology. (wikipedia.org)
  • The oligomeric proanthocyanidins, as a group of distinct compounds are named after the flavonoid compounds they are derived from. (elmaskincare.com)
  • Even during allergy season, many people who suffer from allergies tend to discover that the use of oligomeric proanthocyanidins (OPCs) helps alleviate all noticeable physical symptoms of an allergic reaction - such is the effectiveness of these compounds. (elmaskincare.com)
  • Cranberries contain naturally occurring proanthocyanidins and organic acids, which have been shown to support healthy urinary tract function by inhibiting the attachment of microbes to the linings of the urinary and intestinal tracts. (florahealth.com)
  • 3] Vrhovsek, U., Vanzo A., and Nemanic, J. (2002) Effect of red wine maceration techniques on oligomeric and polymeric proanthocyanidins in wine, cv. (ucdavis.edu)
  • Proanthocyanidins are oligomeric and polymeric end products of the flavonoid biosynthetic pathway. (plants-extracts.com)
  • One major benefit of the oligomeric proanthocyanidins (OPCs) is their extreme potency as antioxidants in the body. (elmaskincare.com)
  • For example, the nutrient vitamin E acts only against fat soluble oxidizing agents in the body, and the vitamin C acts only against water soluble oxidizing agents, the oligomeric proanthocyanidins (OPCs), however, have an active effect against both types of oxidizing agents and are therefore seen as being the most beneficial antioxidants seen in the natural world. (elmaskincare.com)
  • Oligomeric proanthocyanidins (OPCs) have other beneficial effects as well, helping reduce inflammation in the tissues as well as stabilizing the walls of different blood vessels in the body, and in supporting tissues that are rich in collagen and elastin . (elmaskincare.com)
  • Oligomeric proanthocyanidins (OPCs) also positively affect the proteins found in cartilage, in the tendons, the blood vessels, keep skin young and elastic, and aid muscle growth and maintenance. (elmaskincare.com)
  • Oligomeric proanthocyanidins (OPCs) are the best supplement for vascular health among all the herbs and herbal supplements - they actively support and bolster the vascular system in the body. (elmaskincare.com)
  • Oligomeric proanthocyanidins (OPCs) also help prevent the inflammation and swelling of tissues caused by allergic reactions in the body. (elmaskincare.com)
  • Demand for proanthocyanidin-rich supplements has increased as the incidence and prevalence of lifestyle-related diseases such as diabetes and cardiovascular disease has increased. (techmisha.com)
  • It was Masquelier who first developed techniques for the extraction of proanthocyanidins from certain plant species. (chinaadditives.net)
  • These antioxidants, especially resveratrol and proanthocyanidins, are believed to be responsible for the health benefits of red wine. (healthline.com)
  • In particular, the U.S. is witnessing substantial uptake of proanthocyanidins as dietary supplements. (tmrblog.com)
  • The lack of analytical methods to determine authenticity of proanthocyanidins (PAC) in functional foods and dietary supplements is a problem in market regulation and development of efficacious products. (researchgate.net)
  • L-Arginine Proanthocyanidins Sachets - L-Arginine + Proanthocyanidin is a supplement that combines two nutrients. (pharmaadda.in)
  • These include resveratrol, catechin, epicatechin and proanthocyanidins ( 5 ). (healthline.com)
  • Proanthocyanidin (PRO) has been implicated in a variety of biological functions, such as antibacterial, antioxidant , and anti- obesity effects. (bvsalud.org)
  • Proanthocyanidins, such as those found in red wine, are natural polyphenolic bioflavonoids that are widespread in nature and highly regarded for their strong antioxidant properties, as well as their functions in supporting the body's connective tissues. (acuatlanta.net)
  • Antioxidant properties of proanthocyanidins attenuate CCl4-induced steatosis and liver injury in rates via CPY2E1 regulation. (cdc.gov)
  • Oligomeric proanthocyanidins can be extracted via Vaccinium pahalae from in vitro cell culture. (wikipedia.org)
  • We have previously reported the extraction, purification and characterization of the ethyl acetate soluble proanthocyanidins (EASPA) of the inflorescence of Cocos nucifera L. The aqueous soluble proanthocyanidins (AQSPA) were extracted from the immature inflorescence using acetone/water (7:3) and purified using chromatography on sephadex LH-20. (phytojournal.com)
  • Functional Characterization and Toxicological Study of Proanthocyanidins in Weaned Pigs. (bvsalud.org)
  • Apples contain on average per serving about eight times the amount of proanthocyanidin found in wine, with some of the highest amounts found in the Red Delicious and Granny Smith varieties. (wikipedia.org)
  • Our objective was to assess the efficacy of a high dose cranberry proanthocyanidin extract for the prevention of recurrent urinary tract infection. (biomedcentral.com)
  • Molecular docking studies suggest that cranberry-derived proanthocyanidin binds to QS transcriptional regulators, mainly interacting with their ligand binding sites. (nature.com)
  • the grape skins typically contain higher mean degrees of polymerization, and the seed proanthocyanidins contained in the outer coat and endosperm often have lower average molecular weights, which has been correlated to a bitter taste 3 . (ucdavis.edu)
  • In the present study, we aimed to investigate the molecular mechanisms and prophylactic effects of grape seed proanthocyanidin (GSP) on lipopolysaccharide (LPS)-stimulated human hepatic stellate cells (HSCs). (spandidos-publications.com)
  • However, AQSPA is comprised of high molecular weight proanthocyanidins and the oligomeric profile is different to that of EASPA. (phytojournal.com)
  • Participants were randomized to receive a high dose of standardized, commercially available cranberry proanthocyanidins (2 × 18.5 mg daily, n = 72) or a control low dose (2 × 1 mg daily, n = 73) for a 24-week period. (biomedcentral.com)
  • Proanthocyanidins with interestingly different A-type linkages were identified in plums and cinnamon. (marscocoascience.com)
  • A variety of proanthocyanidins have multiple functions such as antibacterial, antiviral ( 5 ), anticarcinogenic ( 5 , 6 ) and anti-inflammatory activity ( 7 ). (spandidos-publications.com)
  • High dose twice daily proanthocyanidin extract was not associated with a reduction in the number of symptomatic urinary tract infections when compared to a low dose proanthocyanidin extract. (biomedcentral.com)
  • Our post-hoc results reveal that this high dose of proanthocyanidins may have a preventive impact on symptomatic urinary tract infection recurrence in women who experienced less than 5 infections per year. (biomedcentral.com)
  • Standardization of cranberry products and specifying proanthocyanidin (PAC) content may help to clarify results and resolve the discrepancy. (msdmanuals.com)
  • Proanthocyanidin-rich foods are in high demand due to the increasing demand for anti-cancer foods in communities all over the world. (techmisha.com)
  • Liquid chromatographic/electrospray ionization mass spectrometric studies of proanthocyanidins in foods. (marscocoascience.com)
  • The proanthocyanidins in three foods (pinto beans, plums and cinnamon) were studied with electrospray ionization (ESI) mass spectrometry (MS) in the negative mode following separation by normal-phase high-performance liquid chromatography. (marscocoascience.com)
  • Material/Methods: Thirty-two Rattus Norvegicus rats were categorized equally as the control group (CG), proanthocyanidin group (PCG), ischemia group (IG) and proanthocyanidin-treated group (PCT). (medscimonit.com)
  • Proanthocyanidins have been sold as nutritional and therapeutic supplements in Europe since the 1980s, but their introduction to the United States market has been relatively recent. (chinaadditives.net)
  • Furthermore, rising consumer understanding of the nutritional and therapeutic benefits of natural extracts such as proanthocyanidins has enticed many companies to produce supplements derived from natural extracts such as proanthocyanidins, propelling the market forward. (techmisha.com)
  • Moreover, growing consumer awareness about the health and nutritional benefits of proanthocyanidins as supplements has bolstered their demand in various parts of the world. (tmrblog.com)
  • Proanthocyanidin glycosides can be isolated from cocoa liquor. (wikipedia.org)
  • Rising demand for proanthocyanidin-rich food products in a number of developing and developed regions is helping the rapid evolution of the proanthocyanidins market. (tmrblog.com)
  • The rising demand for food products with anti-cancer properties in populations across the world is also fueling the demand for proanthocyanidin-rich food products. (tmrblog.com)
  • Wholesale Trader of a wide range of products which include l arginine proanthocyanidin sachet. (vinsonpharma.in)
  • The methylcellulose and protein precipitation assays could not quantify proanthocyanidins in rosé and white wines. (pucv.cl)
  • P-trend = 0.07) but not for proanthocyanidins with a greater polymerization degree. (nih.gov)
  • Proanthocyanidins are also being used in numerous application areas in the food and beverages, and personal care and cosmetics industries. (tmrblog.com)
  • Novel heterogeneous B-type proanthocyanidins containing (epi)afzelechin as subunits were identified in pinto beans. (marscocoascience.com)
  • In nature, proanthocyanidins serve among other chemical and induced defense mechanisms against plant pathogens and predators, such as occurs in strawberries. (wikipedia.org)