A contagious, neoplastic, pulmonary disease of sheep characterized by hyperplasia and hypertrophy of pneumocytes and epithelial cells of the lung. It is caused by JAAGSIEKTE SHEEP RETROVIRUS.
A genus of the family RETROVIRIDAE consisting of viruses with either type B or type D morphology. This includes a few exogenous, vertically transmitted and endogenous viruses of mice (type B) and some primate and sheep viruses (type D). MAMMARY TUMOR VIRUS, MOUSE is the type species.
A neoplastic disease in which the alveoli and distal bronchi are filled with mucus and mucus-secreting columnar epithelial cells. It is characterized by abundant, extremely tenacious sputum, chills, fever, cough, dyspnea, and pleuritic pain. (Stedman, 25th ed)
A benign epithelial tumor of the LIVER.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
A group of autosomal dominant diseases characterized by the combined occurrence of tumors involving two or more ENDOCRINE GLANDS that secrete PEPTIDE HORMONES or AMINES. These neoplasias are often benign but can be malignant. They are classified by the endocrine glands involved and the degree of aggressiveness. The two major forms are MEN1 and MEN2 with gene mutations on CHROMOSOME 11 and CHROMOSOME 10, respectively.
The growth of INTESTINAL POLYPS. Growth processes include neoplastic (ADENOMA and CARCINOMA) and non-neoplastic (hyperplastic, mucosal, inflammatory, and other polyps).
A synthetic progestational hormone used often in mixtures with estrogens as an oral contraceptive.
Tumors or cancer of the DUODENUM.
A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood.
Discrete abnormal tissue masses that protrude into the lumen of the INTESTINE. A polyp is attached to the intestinal wall either by a stalk, pedunculus, or by a broad base.
A benign epithelial tumor with a glandular organization.

Complete sequence of enzootic nasal tumor virus, a retrovirus associated with transmissible intranasal tumors of sheep. (1/48)

The sequence of the complete genome of ovine enzootic nasal tumor virus, an exogenous retrovirus associated exclusively with contagious intranasal tumors of sheep, was determined. The genome is 7,434 nucleotides long and exhibits a genetic organization characteristic of type B and D oncoviruses. Enzootic nasal tumor virus is closely related to the Jaagsiekte sheep retrovirus and to sheep endogenous retroviruses.  (+info)

Jaagsiekte retrovirus is widely distributed both in T and B lymphocytes and in mononuclear phagocytes of sheep with naturally and experimentally acquired pulmonary adenomatosis. (2/48)

Jaagsiekte sheep retrovirus (JSRV) is a type D retrovirus specifically associated with a contagious lung tumor of sheep, sheep pulmonary adenomatosis (SPA). JSRV replicates actively in the transformed epithelial cells of the lung, and JSRV DNA and RNA have been detected in lymphoid tissues of naturally affected animals. To determine the lymphoid target cells of JSRV, CD4(+) T cells, CD8(+) T cells, B lymphocytes, and adherent cell (macrophage/monocyte) populations were isolated from the mediastinal lymph nodes of naturally affected sheep and lambs inoculated with JSRV. Cells were enriched to high purity and then analyzed for JSRV proviral DNA by heminested PCR, and the proviral burden was quantitated by limiting dilution analysis. JSRV proviral DNA was found in all subsets examined but not in appropriate negative controls. In sheep naturally affected with SPA, JSRV proviral burden was greatest in the adherent cell population. In the nonadherent lymphocyte population, surface immunoglobulin-positive B cells contained the greatest proviral burden, while CD4(+) and CD8(+) T cells contained the lowest levels of JSRV proviral DNA. In most of the cases (5 of 8), provirus also could be detected in the peripheral blood mononuclear cell (PBMC) population. A kinetic study of JSRV infection in the mediastinal lymphocyte population of newborn lambs inoculated with JSRV found that JSRV proviral DNA could be detected as early as 7 days postinoculation before the onset of pulmonary adenomatosis, although the proviral burden was greatly reduced compared to adult natural cases. This was reflected in the levels found in PBMC since proviral DNA was detected in 2 of 13 animals. At the early time points studied (7 to 28 days postinoculation) no one subset was preferentially infected. These data indicate that JSRV can infect lymphoid and phagocytic mononuclear cells of sheep and that dissemination precedes tumor formation. Infection of lymphoid tissue, therefore, may play an important role in the pathogenesis of SPA.  (+info)

Sequence comparison of JSRV with endogenous proviruses: envelope genotypes and a novel ORF with similarity to a G-protein-coupled receptor. (3/48)

Ovine pulmonary carcinoma, a contagious lung cancer of sheep, is caused by the oncogenic jaagsiekte sheep retrovirus (JSRV) that is closely related to a family of endogenous sheep retroviral sequences (ESRVs). By using exogenous virus-specific U3 oligonucleotide primers, the entire JSRV proviral genome or its 3' part was amplified from tumor DNA. Analysis of these proviral sequences revealed a novel open reading frame (ORF) within the pol coding region, designated ORF X, which was well conserved in ESRV and JSRV sequences. Deduced amino acids of ORF X showed similarity to a portion of the mammalian adenosine receptor subtype 3, a member of the G-protein-coupled receptor family. Comparison of deduced env amino acids of six JSRV strains from three continents identified 15 residues that defined two distinct genotypes of JSRVs. Sequence analysis identified two highly variable regions between JSRV and ESRV in the transmembrane domain of env (TM) and the 3' unique sequence (U3) of the long terminal repeat, from which JSRV-specific DNA probes were derived. By using these DNA probes in Southern hybridization, for the first time we successfully identified JSRV proviral sequences in tumor genomic DNA in the presence of multiple ESRV loci, validating the use of exogenous virus-specific DNA probes in the analysis of oncogenic proviral integration sites and identification of integrated exogenous proviral sequences.  (+info)

Jaagsiekte sheep retrovirus is necessary and sufficient to induce a contagious lung cancer in sheep. (4/48)

Sheep pulmonary adenomatosis (SPA) is a contagious and experimentally transmissible lung cancer of sheep resembling human bronchiolo-alveolar carcinoma. A type D retrovirus, known as jaagsiekte sheep retrovirus (JSRV), has been associated with the etiology of SPA, but its exact role in the induction of the tumor has not been clear due to the lack of (i) a tissue culture system for the propagation of JSRV and (ii) an infectious JSRV molecular clone. To investigate the role of JSRV in the etiology of SPA, we isolated a full-length JSRV proviral clone, pJSRV21, from a tumor genomic DNA library derived from a natural case of SPA. pJSRV21 was completely sequenced and showed open reading frames in agreement with those deduced for the original South African strain of JSRV. In vivo transfection of three newborn lambs by intratracheal inoculation with pJSRV21 DNA complexed with cationic lipids showed that pJSRV21 is an infectious molecular clone. Viral DNA was detected in the peripheral blood mononuclear cells (PBMCs) of the transfected animals by a highly sensitive JSRV-U3 heminested PCR at various time points ranging from 2 weeks to 6 months posttransfection. In addition, proviral DNA was detected in the PBMCs, lungs, and mediastinal lymph nodes of two lambs sacrificed 9 months posttransfection, but no macroscopic or histological SPA lesion was induced. We prepared JSRV particles by transient transfection of 293T cells with a JSRV construct (pCMV2JS21) in which the upstream U3 was replaced with the cytomegalovirus early promoter. Four newborn lambs were inoculated with JSRV21 particles produced in this manner, and two of them showed the classical signs of SPA 4 months postinfection. The resulting tumors were positive for JSRV DNA and protein. Thus, JSRV21 is an infectious and pathogenic molecular clone and is necessary and sufficient to induce sheep pulmonary adenomatosis.  (+info)

In vitro infection of ovine cell lines by Jaagsiekte sheep retrovirus. (5/48)

Sheep pulmonary adenomatosis (SPA), also known as jaagsiekte or ovine pulmonary carcinoma, is a contagious lung cancer of sheep, originating from type II pneumocytes and Clara cells. Previous studies have implicated a type D retrovirus (jaagsiekte sheep retrovirus [JSRV]) as the causative agent of SPA. We recently isolated a proviral clone of JSRV from an animal with a spontaneous case of SPA (JSRV(21)) and showed that it harbors an infectious and oncogenic virus. This demonstrated that JSRV is necessary and sufficient to induce SPA. A major impediment in research on JSRV has been the lack of an in vitro tissue culture system for the virus. The experiments reported here show the first successful in vitro infection with this virus, using the JSRV(21) clone. JSRV(21) virus was obtained by transiently transfecting human 293T cells with a plasmid containing the JSRV(21) provirus driven by the human cytomegalovirus immediate-early promoter. Virus produced in this manner exhibited reverse transcriptase (RT) activity that banded at 1.15 g/ml in sucrose density gradients. Infection of concentrated JSRV(21) into ovine choroid plexus (CP), testes (OAT-T3), turbinate (FLT), and intestinal carcinoma (ST6) cell lines resulted in establishment of infection as measured by PCR amplification. Evidence that this reflected genuine infection included the fact that heat inactivation of the virus eliminated it, the levels of viral DNA increased with passage of the infected cells, and the infected cells released active RT as measured by the sensitive product enhancement RT assay. The RT activity released from the infected cells banded at 1.15 g/ml, and JSRV(21) provirus was transmitted from infected cells to uninfected ones by cocultivation. However, the amount of virus released from infected cells was low. These results suggest that the JSRV receptor is present on many ovine cell types and that the observed restriction of JSRV expression in vivo to tumor cells might be controlled by factors other than the viral receptor. Finally we tagged the U3 of pJSRV(21) with the bacterial supF gene, an amber suppressor tRNA gene. The resulting clone, termed pJSRV(supF), is infectious in vitro. It may be a useful tool for future studies on viral DNA integration, since the normal sheep genome contains 15 to 20 copies of highly JSRV-related endogenous sequences that cross-react with many JSRV hybridization probes.  (+info)

Retrovirus vectors bearing jaagsiekte sheep retrovirus Env transduce human cells by using a new receptor localized to chromosome 3p21.3. (6/48)

Jaagsiekte sheep retrovirus (JSRV) is a type D retrovirus associated with a contagious lung tumor of sheep, ovine pulmonary carcinoma. Other than sheep, JSRV is known to infect goats, but there is no evidence of human infection. Until now it has not been possible to study the host range for JSRV because of the inability to grow this virus in culture. Here we show that the JSRV envelope protein (Env) can be used to pseudotype Moloney murine leukemia virus (MoMLV)-based retrovirus vectors and that such vectors can transduce human cells in culture. We constructed hybrid retrovirus packaging cells that express the JSRV Env and the MoMLV Gag-Pol proteins and can produce JSRV-pseudotype vectors at titers of up to 10(6) alkaline phosphatase-positive focus-forming units/ml. Using this high-titer virus, we have studied the host range for JSRV, which includes sheep, human, monkey, bovine, dog, and rabbit cells but not mouse, rat, or hamster cells. Considering the inability of the JSRV-pseudotype vector to transduce hamster cells, we used the hamster cell line-based Stanford G3 panel of whole human genome radiation hybrids to phenotypically map the JSRV receptor (JVR) gene within the p21.3 region of human chromosome 3. JVR is likely a new retrovirus receptor, as none of the previously identified retrovirus receptors localizes to the same position. Several chemokine receptors that have been shown to serve as coreceptors for lentivirus infection are clustered in the same region of chromosome 3; however, careful examination shows that the JSRV receptor does not colocalize with any of these genes.  (+info)

The long terminal repeat of Jaagsiekte sheep retrovirus is preferentially active in differentiated epithelial cells of the lungs. (7/48)

Jaagsiekte sheep retrovirus (JSRV) is the etiologic agent of a contagious bronchioloalveolar carcinoma of sheep known as sheep pulmonary adenomatosis (SPA; ovine pulmonary carcinoma). JSRV is unique among retroviruses because it transforms the alveolar type II cells and the nonciliated bronchiolar cells (Clara cells) of the lungs; these cells are where JSRV is specifically expressed in both naturally and experimentally SPA-affected sheep. In this study, we investigated the cell specificity of JSRV expression. By transient-transfection assays of 23 different cell lines with a reporter plasmid driven by the JSRV long terminal repeat (LTR), pJS21-luc, we found that the JSRV LTR is preferentially active in cell lines derived from type II pneumocytes and Clara cells (MLE-15 and mtCC1-2 mouse cell lines). Reporter assays using progressive 5' deletions of pJS21-luc allowed us to establish that the JSRV enhancers are able to activate the JSRV proximal promoter in MLE-15 and mtCC1-2 cells, but they have very low activity in mouse cells of other lineages (e.g., NIH 3T3). The JSRV enhancers are able to activate heterologous promoters in both MLE-15 and 3T3 cells, although optimal activity is achieved in MLE-15 cells only with the homologous JSRV promoter. Thus, JSRV cell-specific LTR activity appears to result from an interaction between the enhancer elements and the JSRV proximal promoter elements. By mutation analysis, we established that an upstream NF-kappaB-like element appears to be responsible for approximately 50% of the JSRV LTR transcriptional activity in MLE-15 cells. Electrophoretic mobility shift assays showed evidence of a factor(s) that binds to this sequence. Antibody supershift experiments indicated that the factor(s) is not related to NF-kappaB component p50 or p52. This factor also appeared to be present in cells that do not support a high level of JSRV expression. Finally the JSRV(21) LTR contains putative enhancer binding motifs for transcription factors such as hepatocyte nuclear factor 3 (HNF-3) that are involved in lung-specific gene expression. Cotransfection experiments demonstrated that exogenous HNF-3 is able to enhance the expression of pJS21-luc in NIH 3T3 cells, which normally show minimal enhancer activity for the JSRV LTR.  (+info)

Molecular cloning and functional analysis of three type D endogenous retroviruses of sheep reveal a different cell tropism from that of the highly related exogenous jaagsiekte sheep retrovirus. (8/48)

Integrated into the sheep genome are 15 to 20 copies of type D endogenous loci that are highly related to two exogenous oncogenic viruses, jaagsiekte sheep retrovirus (JSRV) and enzootic nasal tumor virus (ENTV). The exogenous viruses cause infectious neoplasms of the respiratory tract in small ruminants. In this study, we molecularly cloned three intact type D endogenous retroviruses of sheep (enJS56A1, enJS5F16, and enJS59A1; collectively called enJRSVs) and analyzed their genomic structures, their phylogenies with respect to their exogenous counterparts, their capacity to form viral particles, and the expression specificities of their long terminal repeats (LTRs). In addition, the pattern of expression of enJSRVs in vivo was studied by in situ hybridization. All of the three enJSRV proviruses had open reading frames for at least one of the structural genes. In particular, enJS56A1 had open reading frames for all structural genes, but it could not assemble viral particles when highly expressed in human 293T cells. We localized the defect for viral assembly in the first two-thirds of the gag gene by making a series of chimeras between enJS56A1 and the exogenous infectious molecular clone JSRV(21). Phylogenetic analysis distinguished five ovine type D retroviruses: enJSRV groups A and B, ENTV, and two exogenous JSRV groups (African versus United Kingdom/North America isolates). Transient transfection assays indicated that the LTRs of the three enJSRVs were not preferentially active in differentiated lung epithelial cells. This suggests that the pulmonary tropic JSRV developed from a type D retrovirus that did not have lung specificity. Consistent with this, in situ hybridization of a panel of normal ovine tissues revealed high expression of enJSRV mRNA in the luminal epithelium and glandular epithelium of the uterus; lower expression was localized in the lamina propria of the gut and in the bronchiolar epithelium of the lungs.  (+info)

Pulmonary Adenomatosis, Ovine, also known as Jaagsiekte or ovine pulmonary carcinoma, is a contagious and fatal disease that affects the lungs of sheep. It is caused by a retrovirus called jaagsiekte sheep retrovirus (JSRV). The virus infects the cells in the lung tissue leading to the formation of tumors known as adenomatosis.

The disease is characterized by progressive respiratory distress, weight loss, and eventual death. It is transmitted through the respiratory route, and infected animals can shed the virus in their saliva, nasal secretions, and feces. The disease has a long incubation period, which can range from several months to years, making it difficult to control.

There is no effective treatment for pulmonary adenomatosis, ovine, and infected animals are usually euthanized to prevent the spread of the virus. Prevention measures include quarantine and testing of new sheep before introducing them into a flock, as well as reducing stress and maintaining good nutrition and overall health in the flock.

A betaretrovirus is a type of retrovirus, which is a group of viruses that are characterized by their ability to integrate their genetic material into the DNA of the host cell. Betaretroviruses are further classified based on their specific genetic and biological properties. They are enveloped viruses with a single-stranded, positive-sense RNA genome.

Betaretroviruses include several veterinary pathogens, such as mouse mammary tumor virus (MMTV) and jaagsiekte sheep retrovirus (JSRV). These viruses are associated with various types of cancer in their respective host species. For example, MMTV is associated with mammary tumors in mice, while JSRV is associated with a type of lung cancer in sheep.

It's important to note that betaretroviruses are not known to infect humans and there are no human diseases associated with this group of viruses.

Pulmonary adenomatosis is a rare condition that is characterized by the abnormal growth of benign tumors (adenomas) in the lungs. These tumors are made up of glands and can cause thickening and enlargement of the lung tissue, which can lead to symptoms such as coughing, wheezing, and difficulty breathing. In some cases, pulmonary adenomatosis may also be associated with an increased risk of lung cancer. It is important to note that this condition is different from adenocarcinoma, which is a type of lung cancer that can also arise in the glands of the lungs.

A liver cell adenoma is a benign tumor that develops in the liver and is composed of cells similar to those normally found in the liver (hepatocytes). These tumors are usually solitary, but multiple adenomas can occur, especially in women who have taken oral contraceptives for many years. Liver cell adenomas are typically asymptomatic and are often discovered incidentally during imaging studies performed for other reasons. In rare cases, they may cause symptoms such as abdominal pain or discomfort, or complications such as bleeding or rupture. Treatment options include monitoring with periodic imaging studies or surgical removal of the tumor.

I apologize, but "sheep" is not a term that has a medical definition. It is a common animal with the scientific name Ovis aries. If you have any medical or health-related questions, I would be happy to try and help answer those for you.

Multiple Endocrine Neoplasia (MEN) is a group of inherited disorders characterized by the development of tumors in various endocrine glands, which can lead to overproduction of hormones. There are two main types: MEN type 1 and MEN type 2.

MEN type 1, also known as Wermer's syndrome, is caused by mutations in the MEN1 gene. It typically involves tumors in the parathyroid glands (leading to hyperparathyroidism), pancreas (often gastrinomas or insulinomas), and pituitary gland. Some individuals may also develop tumors in other organs, such as the adrenal glands, lungs, or thyroid gland.

MEN type 2, which includes MEN type 2A and MEN type 2B, is caused by mutations in the RET gene. MEN type 2A involves medullary thyroid carcinoma (MTC), pheochromocytomas (tumors of the adrenal glands), and parathyroid tumors. MEN type 2B includes MTC, pheochromocytomas, neuromas (nerve tissue tumors), and distinctive physical features such as a marfanoid habitus and mucosal neuromas.

Early detection and management of these tumors are crucial to prevent complications from hormone excess or tumor invasion. Regular screening and monitoring are recommended for individuals with MEN, even if they do not have symptoms. Treatment typically involves surgical removal of the affected glands or tumors, along with medications to manage hormonal imbalances.

Intestinal polyposis is a condition characterized by the presence of multiple polyps in the inner lining (mucosa) of the intestines. These polyps are abnormal growths that protrude from the intestinal wall and can vary in size, number, and type. Some common types of polyps include adenomatous, hyperplastic, and inflammatory polyps.

Intestinal polyposis can occur throughout the gastrointestinal tract, including the stomach, small intestine, and large intestine (colon). The condition can be inherited or acquired, and it is often associated with various genetic syndromes such as familial adenomatous polyposis (FAP), Peutz-Jeghers syndrome, juvenile polyposis syndrome, and Lynch syndrome.

Depending on the type, size, and number of polyps, intestinal polyposis can increase the risk of developing colorectal cancer and other gastrointestinal malignancies. Regular surveillance, monitoring, and removal of polyps are essential for managing this condition and preventing complications.

Lynestrenol is a synthetic form of progestogen, which is a female sex hormone. It is used in various medications for different purposes, such as treating abnormal menstrual bleeding, endometriosis, and preventing premature labor. Lynestrenol works by mimicking the effects of natural progesterone in the body, helping to regulate the menstrual cycle and reduce inflammation associated with endometriosis. It is important to note that lynestrenol should only be used under the supervision of a healthcare professional, as it can have side effects and interact with other medications.

Duodenal neoplasms refer to abnormal growths in the duodenum, which is the first part of the small intestine that receives digestive secretions from the pancreas and bile duct. These growths can be benign or malignant (cancerous).

Benign neoplasms include adenomas, leiomyomas, lipomas, and hamartomas. They are usually slow-growing and do not spread to other parts of the body. However, they may cause symptoms such as abdominal pain, bleeding, or obstruction of the intestine.

Malignant neoplasms include adenocarcinomas, neuroendocrine tumors (carcinoids), lymphomas, and sarcomas. They are more aggressive and can invade surrounding tissues and spread to other parts of the body. Symptoms may include abdominal pain, weight loss, jaundice, anemia, or bowel obstruction.

The diagnosis of duodenal neoplasms is usually made through imaging tests such as CT scans, MRI, or endoscopy with biopsy. Treatment depends on the type and stage of the tumor and may include surgery, chemotherapy, radiation therapy, or a combination of these modalities.

Adenomatous Polyposis Coli (APC) is a genetic disorder characterized by the development of numerous adenomatous polyps in the colon and rectum. APC is caused by mutations in the APC gene, which is a tumor suppressor gene that helps regulate cell growth and division. When the APC gene is mutated, it can lead to uncontrolled cell growth and the development of polyps, which can eventually become cancerous.

Individuals with APC typically develop hundreds to thousands of polyps in their colon and rectum, usually beginning in adolescence or early adulthood. If left untreated, APC can lead to colorectal cancer in nearly all affected individuals by the age of 40.

APC is an autosomal dominant disorder, which means that a person has a 50% chance of inheriting the mutated gene from an affected parent. However, some cases of APC may also occur spontaneously due to new mutations in the APC gene. Treatment for APC typically involves surgical removal of the colon and rectum (colectomy) to prevent the development of colorectal cancer. Regular surveillance with colonoscopy is also recommended to monitor for the development of new polyps.

Intestinal polyps are abnormal growths that protrude from the lining of the intestines. They can occur in any part of the digestive tract, including the colon and rectum (colorectal polyps), small intestine, or stomach. These growths vary in size, shape, and number. Most intestinal polyps are benign, meaning they are not cancerous. However, some types of polyps, such as adenomatous polyps, can become cancerous over time if left untreated.

Intestinal polyps can be asymptomatic or cause symptoms like rectal bleeding, abdominal pain, changes in bowel habits, or anemia (in cases where there is chronic, slow bleeding). The exact cause of intestinal polyps is not fully understood, but factors such as age, family history, and certain genetic conditions can increase the risk of developing them. Regular screening exams, like colonoscopies, are essential for early detection and removal of polyps to prevent potential complications, including colorectal cancer.

An adenoma is a benign (noncancerous) tumor that develops from glandular epithelial cells. These types of cells are responsible for producing and releasing fluids, such as hormones or digestive enzymes, into the surrounding tissues. Adenomas can occur in various organs and glands throughout the body, including the thyroid, pituitary, adrenal, and digestive systems.

Depending on their location, adenomas may cause different symptoms or remain asymptomatic. Some common examples of adenomas include:

1. Colorectal adenoma (also known as a polyp): These growths occur in the lining of the colon or rectum and can develop into colorectal cancer if left untreated. Regular screenings, such as colonoscopies, are essential for early detection and removal of these polyps.
2. Thyroid adenoma: This type of adenoma affects the thyroid gland and may result in an overproduction or underproduction of hormones, leading to conditions like hyperthyroidism (overactive thyroid) or hypothyroidism (underactive thyroid).
3. Pituitary adenoma: These growths occur in the pituitary gland, which is located at the base of the brain and controls various hormonal functions. Depending on their size and location, pituitary adenomas can cause vision problems, headaches, or hormonal imbalances that affect growth, reproduction, and metabolism.
4. Liver adenoma: These rare benign tumors develop in the liver and may not cause any symptoms unless they become large enough to press on surrounding organs or structures. In some cases, liver adenomas can rupture and cause internal bleeding.
5. Adrenal adenoma: These growths occur in the adrenal glands, which are located above the kidneys and produce hormones that regulate stress responses, metabolism, and blood pressure. Most adrenal adenomas are nonfunctioning, meaning they do not secrete excess hormones. However, functioning adrenal adenomas can lead to conditions like Cushing's syndrome or Conn's syndrome, depending on the type of hormone being overproduced.

It is essential to monitor and manage benign tumors like adenomas to prevent potential complications, such as rupture, bleeding, or hormonal imbalances. Treatment options may include surveillance with imaging studies, medication to manage hormonal issues, or surgical removal of the tumor in certain cases.

... (OPA), also known as ovine pulmonary adenomatosis, or jaagsiekte, is a chronic and contagious ... It has also been known as sheep pulmonary adenomatosis and ovine pulmonary carcinoma. OPA has been used as an animal model for ... "2.7.9 Ovine pulmonary adenocarcinoma (adenomatosis)" (PDF). Manual of diagnostic tests and vaccines for terrestrial animals ... De Las Heras, M; González, L; Sharp, JM (2003). "Pathology of ovine pulmonary adenocarcinoma". In Fan, Hung (ed.). Jaagsiekte ...
... pulmonary adenomatosis, ovine MeSH C04.557.470.200.150 - carcinoma, adenosquamous MeSH C04.557.470.200.165 - carcinoma, basal ... adenomatosis, pulmonary MeSH C04.557.470.035.215 - adenomatous polyps MeSH C04.557.470.035.215.100 - adenomatous polyposis coli ... pulmonary MeSH C04.588.894.797.520.734 - pancoast's syndrome MeSH C04.588.894.797.520.867 - pulmonary blastoma MeSH C04.588. ... pulmonary blastoma MeSH C04.557.435.710 - rhabdoid tumor MeSH C04.557.435.775 - sarcoma, endometrial stromal MeSH C04.557. ...
... pulmonary adenomatosis, ovine MeSH C22.836.799 - scrapie MeSH C22.836.886 - swayback MeSH C22.836.900 - visna MeSH C22.905.072 ...
... pulmonary adenomatosis, ovine MeSH C02.782.815.800 - sarcoma, avian MeSH C02.782.930.100 - alphavirus infections MeSH C02.782. ... hantavirus pulmonary syndrome MeSH C02.782.147.420.400 - hemorrhagic fever with renal syndrome MeSH C02.782.147.444 - ...
JSRV Ovine pulmonary adenocarcinoma Enzootic nasal adenocarcinoma Yu DL, Linnerth-Petrik NM, Halbert CL, Walsh SR, Miller AD, ... of Jaagsiekte sheep retrovirus in sheep and goats naturally affected by enzootic nasal tumour or sheep pulmonary adenomatosis ... An ovine that grows a tumor will eventually die of suffocation. Tumors form in nose and are contagious. ENTV targets the ... The lack of an extensive immune response may be due to the face that a large portion of the ovine genome is made up of ...
"Pulmonary Adenomatosis, Ovine" by people in this website by year, and whether "Pulmonary Adenomatosis, Ovine" was a major or ... "Pulmonary Adenomatosis, Ovine" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... Pulmonary Adenomatosis, Ovine*Pulmonary Adenomatosis, Ovine. *Adenomatosis, Ovine Pulmonary. *Adenomatoses, Ovine Pulmonary ... Below are the most recent publications written about "Pulmonary Adenomatosis, Ovine" by people in Profiles. ...
keywords = "Immune dysfunctions, Immusupression, Ovine pulmonary adenomatosis, Ovine pulmonary carcinoma",. author = "Rosadio ... derived from naturally affected and experimentally induced sheep pulmonary adenomatosis (SPA, Jaagsiekte, ovine pulmonary ... derived from naturally affected and experimentally induced sheep pulmonary adenomatosis (SPA, Jaagsiekte, ovine pulmonary ... derived from naturally affected and experimentally induced sheep pulmonary adenomatosis (SPA, Jaagsiekte, ovine pulmonary ...
Ovine pulmonary adenocarcinoma (OPA), also known as ovine pulmonary adenomatosis, or jaagsiekte, is a chronic and contagious ... It has also been known as sheep pulmonary adenomatosis and ovine pulmonary carcinoma. OPA has been used as an animal model for ... "2.7.9 Ovine pulmonary adenocarcinoma (adenomatosis)" (PDF). Manual of diagnostic tests and vaccines for terrestrial animals ... De Las Heras, M; González, L; Sharp, JM (2003). "Pathology of ovine pulmonary adenocarcinoma". In Fan, Hung (ed.). Jaagsiekte ...
... ovine pulmonary adenomatosis, contagious agalactiae, ovine epididymitis, maedi-visna, Q fever, salmonellosis, ... ovine pulmonary adenomatosis, contagious agalactiae, bovine epididymitis, maedi-visna, Q fever, salmonellosis, ...
The etiology and pathogenesis of ovine pulmonary carcinoma (sheep pulmonary adenomatosis). Demartini, J. C., Rosadio, R. H. & ... Retrovirus-associated Ovine Pulmonary Carcinoma (Sheep Pulmonary Adenomatosis) and Lymphoid Interstitial Pneumonia. I. Lesion ... Detection and quantitation of a type D retrovirus gag protein in ovine pulmonary carcinoma (sheep pulmonary adenomatosis) by ... Lesions and Retroviruses Associated with Naturally Occurring Ovine Pulmonary Carcinoma (Sheep Pulmonary Adenomatosis). Rosadio ...
Pulmonary Adenomatosis, Ovine. A contagious, neoplastic, pulmonary disease of sheep characterized by hyperplasia and ... Maedi is a progressive pneumonia of sheep which is similar to but not the same as jaagsiekte (PULMONARY ADENOMATOSIS, OVINE). ... ExperimentalAcquired Immunodeficiency SyndromePulmonary Adenomatosis, OvineViremiaFeline Acquired Immunodeficiency Syndrome ... A species of LENTIVIRUS, subgenus ovine-caprine lentiviruses (LENTIVIRUSES, OVINE-CAPRINE), closely related to VISNA-MAEDI ...
ovine pulmonary adenomatosis DOID:5399 * craniofacial abnormality DOID:10334 * glandular cystitis DOID:2392 ...
Salvatori, D. (2005): Studies on the Pathogenesis and Epidemiology of Ovine Pulmonary Adenomatosis (OPA). PhD Thesis, ... an investigation of growth factors and lactoferrin in naturally occurring ovine Pulmonary Adenomatosis. Lib.Bioinfo.Pl/Paper: ... Ovine pulmonary adenocarcinoma (OPA), also known as jaagsiekte, is a transmissible lung tumor of sheep caused by jaagsiekte ... Dawson, M., Venables, C. and Jenkins, C.E. (1985): Experimental infection of a natural case of Sheep Pulmonary Adenomatosis ...
Ovine Pulmonary Adenomatosis) amongst others. ... WVSC NEWSLETTER EDITION 43 OVINE ABORTION SPECIAL * WVSC ...
It was formerly believed to be identical with jaagsiekte (pulmonary adenomatosis, ovine) but is now recognized as a separate ...
Pulmonary Adenomatosis, Ovine. *Trophoblastic Neoplasms. *Choriocarcinoma. *Gestational Trophoblastic Disease. Below are MeSH ...
Pulmonary Adenomatosis, Ovine [C04.557.470.200.025.715] * Neoplasms [C04] * Neoplasms by Histologic Type [C04.557] * Neoplasms ...
Jaagsiekte use Pulmonary Adenomatosis, Ovine Jaagsiekte Retrovirus use Jaagsiekte sheep retrovirus Jaagsiekte Retroviruses use ...
... tence of Maedi-Visna and sheep pulmonary adenomatosis. Res. Vet. Sci. 1993, 54, 140-146. [Google Scholar] [CrossRef] ... Ellis, J.A.; DeMartini, J.C. Ovine interleukin-2: Partial purification and assay in normal sheep and sheep with ovine ... Microsatellites in immune-relevant regions and their associations with Maedi-Visna and ovine pulmonary adenocarcinoma viral ... In the ovine species, VMV infection increases the expression level of the MHC Class II in the lung, the CNS and the synovium [ ...
Pulmonary Adenomatosis, Ovine. *Sarcoma, Avian. *Warts. Below are MeSH descriptors whose meaning is more specific than "Marek ...
Pulmonary Adenomatosis, Ovine. Search for this term in our Faculty Database. View this term at the NCBI website ...
Pulmonary Adenomatosis, Ovine. *Liver Neoplasms. *Adenoma, Liver Cell. *Carcinoma, Hepatocellular. *Liver Neoplasms, ...
Pulmonary Adenomatosis, Ovine. *Carcinoma in Situ. *Adenocarcinoma in Situ. *Breast Carcinoma In Situ ...
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Jaagsiekte use Pulmonary Adenomatosis, Ovine Jaagsiekte sheep retrovirus Jaborandi Jacaranda caroba Jacaranda gualandai ...
Jaagsiekte use Pulmonary Adenomatosis, Ovine Jaagsiekte sheep retrovirus Jaborandi Jacaranda caroba Jacaranda gualandai use ...
Jaagsiekte use Pulmonary Adenomatosis, Ovine. Jaagsiekte sheep retrovirus. Jaborandi. Jacaranda caroba. Jacaranda gualandai ...
Jaagsiekte use Pulmonary Adenomatosis, Ovine Jaagsiekte sheep retrovirus Jaborandi Jacaranda caroba Jacaranda gualandai ...
Jaagsiekte use Pulmonary Adenomatosis, Ovine Jaagsiekte Retrovirus use Jaagsiekte sheep retrovirus Jaagsiekte Retroviruses use ...
Jaagsiekte use Pulmonary Adenomatosis, Ovine Jaagsiekte sheep retrovirus Jaborandi Jacaranda caroba Jacaranda gualandai use ...
Jaagsiekte use Pulmonary Adenomatosis, Ovine Jaagsiekte Retrovirus use Jaagsiekte sheep retrovirus Jaagsiekte Retroviruses use ...
Jaagsiekte use Pulmonary Adenomatosis, Ovine Jaagsiekte sheep retrovirus Jaborandi Jacaranda caroba Jacaranda gualandai use ...
Jaagsiekte use Pulmonary Adenomatosis, Ovine Jaagsiekte sheep retrovirus Jaborandi Jacaranda caroba Jacaranda gualandai use ...
Jaagsiekte use Pulmonary Adenomatosis, Ovine Jaagsiekte sheep retrovirus Jaborandi Jacaranda caroba Jacaranda gualandai ...
Jaagsiekte use Pulmonary Adenomatosis, Ovine Jaagsiekte Retrovirus use Jaagsiekte sheep retrovirus Jaagsiekte Retroviruses use ...
  • Monoclonal antibodies have been used to characterize peripheral and pulmonary leukocytes (bronchoalveolar lavage ce lis) derived from naturally affected and experimentally induced sheep pulmonary adenomatosis (SPA, Jaagsiekte, ovine pulmonary carcinoma) cases. (edu.pe)
  • It has also been known as sheep pulmonary adenomatosis and ovine pulmonary carcinoma. (wikipedia.org)
  • Retrovirus-associated Ovine Pulmonary Carcinoma (Sheep Pulmonary Adenomatosis) and Lymphoid Interstitial Pneumonia. (edu.pe)
  • Pathology of human bronchioloalveolar carcinoma and its relationship to the ovine disease. (nih.gov)
  • Enzootic nasal adenocarcinoma Jaagsiekte sheep retrovirus Enzootic nasal tumor virus "2.7.9 Ovine pulmonary adenocarcinoma (adenomatosis)" (PDF). (wikipedia.org)
  • Ovine pulmonary adenocarcinoma (OPA), also known as jaagsiekte, is a transmissible lung tumor of sheep caused by jaagsiekte sheep retrovirus (JSRV). (siftdesk.org)
  • In vitro infection of ovine cell lines by Jaagsiekte sheep retrovirus. (nih.gov)
  • A contagious, neoplastic, pulmonary disease of sheep characterized by hyperplasia and hypertrophy of pneumocytes and epithelial cells of the lung. (uchicago.edu)
  • Ovine pulmonary adenocarcinoma (OPA), also known as ovine pulmonary adenomatosis, or jaagsiekte, is a chronic and contagious disease of the lungs of sheep and goats. (wikipedia.org)
  • Seroreactivity of Peruvian sheep and goats to small ruminant lentivirus-ovine progressive pneumonia virus. (edu.pe)
  • A BETARETROVIRUS that causes pulmonary adenomatosis in sheep ( PULMONARY ADENOMATOSIS, OVINE ). (lookformedical.com)
  • Dawson, M., Venables, C. and Jenkins, C.E. (1985): Experimental infection of a natural case of Sheep Pulmonary Adenomatosis with Maedi-Visna Virus. (siftdesk.org)
  • Characterization and relative abundance of alternatively spliced luteinizing hormone receptor messenger ribonucleic acid in the ovine ovary. (geneticsmr.com)
  • This graph shows the total number of publications written about "Pulmonary Adenomatosis, Ovine" by people in this website by year, and whether "Pulmonary Adenomatosis, Ovine" was a major or minor topic of these publications. (uchicago.edu)
  • The present study showed that ovine gastrointestinal nematodes are of the major cause of helminthiasis in the study area. (ijlr.org)
  • It has also been known as sheep pulmonary adenomatosis and ovine pulmonary carcinoma. (wikipedia.org)
  • BACKGROUND: Ovine pulmonary adenocarcinoma (OPA) is a worldwide contagious bronchioalveolar carcinoma caused by infection of a beta retrovirus in sheep and less in goat. (ac.ir)
  • Ovine pulmonary adenocarcinoma (OPA) is a contagious retroviral bronchioalveolar carcinoma in sheep that is rarely observed in goats. (ac.ir)
  • Ovine pulmonary adenocarcinoma (OPA), also known as ovine pulmonary adenomatosis, or jaagsiekte, is a chronic and contagious disease of the lungs of sheep and goats. (wikipedia.org)
  • A contagious, neoplastic, pulmonary disease of sheep characterized by hyperplasia and hypertrophy of pneumocytes and epithelial cells of the lung. (nih.gov)
  • METHODES: A total of 7952 ovine lungs were studied for macroscopic and microscopic pathology examination and so checking TTF1 marker. (ac.ir)