A severe, rapidly fatal reaction occurring most commonly in children following an infectious illness. It is characterized by large, rapidly spreading skin hemorrhages, fever, or shock. Purpura fulminans often accompanies or is triggered by DISSEMINATED INTRAVASCULAR COAGULATION.
A systemic non-thrombocytopenic purpura caused by HYPERSENSITIVITY VASCULITIS and deposition of IGA-containing IMMUNE COMPLEXES within the blood vessels throughout the body, including those in the kidney (KIDNEY GLOMERULUS). Clinical symptoms include URTICARIA; ERYTHEMA; ARTHRITIS; GASTROINTESTINAL HEMORRHAGE; and renal involvement. Most cases are seen in children after acute upper respiratory infections.
Purplish or brownish red discoloration, easily visible through the epidermis, caused by hemorrhage into the tissues. When the size of the discolorization is >2-3 cm it is generally called Ecchymoses (ECCHYMOSIS).
An absence or deficiency in PROTEIN C which leads to impaired regulation of blood coagulation. It is associated with an increased risk of severe or premature thrombosis. (Stedman's Med. Dict., 26th ed.)
A vitamin-K dependent zymogen present in the blood, which, upon activation by thrombin and thrombomodulin exerts anticoagulant properties by inactivating factors Va and VIIIa at the rate-limiting steps of thrombin formation.
Infections with bacteria of the species NEISSERIA MENINGITIDIS.
Thrombocytopenia occurring in the absence of toxic exposure or a disease associated with decreased platelets. It is mediated by immune mechanisms, in most cases IMMUNOGLOBULIN G autoantibodies which attach to platelets and subsequently undergo destruction by macrophages. The disease is seen in acute (affecting children) and chronic (adult) forms.
An acquired, congenital, or familial disorder caused by PLATELET AGGREGATION with THROMBOSIS in terminal arterioles and capillaries. Clinical features include THROMBOCYTOPENIA; HEMOLYTIC ANEMIA; AZOTEMIA; FEVER; and thrombotic microangiopathy. The classical form also includes neurological symptoms and end-organ damage, such as RENAL FAILURE.
A chronic disorder of the pilosebaceous apparatus associated with an increase in sebum secretion. It is characterized by open comedones (blackheads), closed comedones (whiteheads), and pustular nodules. The cause is unknown, but heredity and age are predisposing factors.
Inflammation of the SACROILIAC JOINT. It is characterized by lower back pain, especially upon walking, fever, UVEITIS; PSORIASIS; and decreased range of motion. Many factors are associated with and cause sacroiliitis including infection; injury to spine, lower back, and pelvis; DEGENERATIVE ARTHRITIS; and pregnancy.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A cell surface glycoprotein of endothelial cells that binds thrombin and serves as a cofactor in the activation of protein C and its regulation of blood coagulation.

Meningococcemia without meningitis in Japan. (1/10)

We report a case of meningococcemia without meningitis, which is a rare infectious disease in Japan. A 32-year-old woman was referred to our hospital with fever and joint pain. Her clinical presentation and the results of laboratory examination on admission suggested viral infection. However, her condition rapidly progressed to septic shock with fulminans purpura. Blood culture grew Neisseria meningitidis. She received antimicrobial therapy and underwent localized therapy for skin lesions. Meningococcal infection should be considered in patients who have fever along with skin rash or petechiae even when there are no signs of meningitis. In this report, we also review case reports of meningococcemia without meningitis in Japan.  (+info)

Varicella-associated purpura fulminans and multiple deep vein thromboses: a case report. (2/10)

Varicella-associated purpura fulminans is a rare syndrome associated with substantial morbidity and mortality. General supportive care, heparinization, and plasma infusions are the mainstays of treatment. A patient aged 8 years and 8 months with purpura fulminans and multiple deep vein thromboses after varicella infection because of deficiencies of proteins C and S is presented in this case report.  (+info)

Purpura fulminans as the presenting manifestation in a patient with juvenile SLE. (3/10)

We present a 12-year-old girl with systemic lupus erythematosus and associated antiphospholipid syndrome who developed an unusual manifestation of purpura fulminans in an accelerated fashion. The patient improved after prompt treatment with anticoagulants, aggressive immunosuppressive drugs and plasmapheresis. This is the first pediatric case of purpura fulminans due to secondary antiphospholipid syndrome of systemic lupus erythematosus. We suggest that SLE patients with lupus anticoagulant should be followed closely for similar complications.  (+info)

Human protein C concentrate in the treatment of purpura fulminans: a retrospective analysis of safety and outcome in 94 pediatric patients. (4/10)

 (+info)

Long-term subcutaneous protein C replacement in neonatal severe protein C deficiency. (5/10)

 (+info)

Adult purpura fulminans associated with non-steroidal anti-inflammatory drug use. (6/10)

 (+info)

Spectrum of purpura fulminans: report of three classical prototypes and review of management strategies. (7/10)

 (+info)

Atypical presentation of purpura fulminans following sepsis in an adult. (8/10)

 (+info)

Purpura fulminans is a severe, life-threatening condition characterized by the rapid progression of hemorrhagic purpura (discoloration of the skin due to bleeding under the skin) and disseminated intravascular coagulation (DIC), leading to thrombosis and necrosis of the skin and underlying tissues. It can be classified into two types: acute infectious purpura fulminans, which is caused by bacterial infections such as meningococcus or pneumococcus; and chronic purpura fulminans, which is associated with autoimmune disorders or protein C or S deficiencies. The condition can lead to serious complications such as sepsis, organ failure, and death if not promptly diagnosed and treated.

Henoch-Schönlein purpura (HSP) is a type of small vessel vasculitis, which is a condition characterized by inflammation of the blood vessels. HSP primarily affects children, but it can occur in adults as well. It is named after two German physicians, Eduard Heinrich Henoch and Johann Schönlein, who first described the condition in the mid-19th century.

The main feature of HSP is a purpuric rash, which is a type of rash that appears as small, red or purple spots on the skin. The rash is caused by leakage of blood from the small blood vessels (capillaries) beneath the skin. In HSP, this rash typically occurs on the legs and buttocks, but it can also affect other parts of the body, such as the arms, face, and trunk.

In addition to the purpuric rash, HSP is often accompanied by other symptoms, such as joint pain and swelling, abdominal pain, nausea, vomiting, and diarrhea. In severe cases, it can also affect the kidneys, leading to hematuria (blood in the urine) and proteinuria (protein in the urine).

The exact cause of HSP is not known, but it is thought to be related to an abnormal immune response to certain triggers, such as infections or medications. Treatment typically involves supportive care, such as pain relief and fluid replacement, as well as medications to reduce inflammation and suppress the immune system. In most cases, HSP resolves on its own within a few weeks or months, but it can lead to serious complications in some individuals.

Purpura is a medical term that refers to the appearance of purple-colored spots on the skin or mucous membranes, caused by bleeding underneath the skin due to various factors such as blood clotting disorders, vasculitis (inflammation of the blood vessels), severe thrombocytopenia (low platelet count), or use of certain medications. These spots can vary in size and shape, ranging from small pinpoint hemorrhages (petechiae) to larger, irregularly shaped patches (ecchymoses). The bleeding is usually not caused by trauma or injury to the area. It's important to consult a healthcare professional if you notice any unexplained purpuric spots on your skin or mucous membranes, as they can indicate an underlying medical condition that requires further evaluation and treatment.

Protein C deficiency is a genetic disorder that affects the body's ability to control blood clotting. Protein C is a protein in the blood that helps regulate the formation of blood clots. When blood clots form too easily or do not dissolve properly, they can block blood vessels and lead to serious medical conditions such as deep vein thrombosis (DVT) or pulmonary embolism (PE).

People with protein C deficiency have lower than normal levels of this protein in their blood, which can increase their risk of developing abnormal blood clots. The condition is usually inherited and present from birth, but it may not cause any symptoms until later in life, such as during pregnancy, after surgery, or due to other factors that increase the risk of blood clots.

Protein C deficiency can be classified into two types: type I and type II. Type I deficiency is characterized by lower than normal levels of both functional and immunoreactive protein C in the blood. Type II deficiency is characterized by normal or near-normal levels of immunoreactive protein C, but reduced functional activity.

Protein C deficiency can be diagnosed through blood tests that measure the level and function of protein C in the blood. Treatment may include anticoagulant medications to prevent blood clots from forming or dissolve existing ones. Regular monitoring of protein C levels and careful management of risk factors for blood clots are also important parts of managing this condition.

Protein C is a vitamin K-dependent protease that functions as an important regulator of coagulation and inflammation. It is a plasma protein produced in the liver that, when activated, degrades clotting factors Va and VIIIa to limit thrombus formation and prevent excessive blood clotting. Protein C also has anti-inflammatory properties by inhibiting the release of pro-inflammatory cytokines and reducing endothelial cell activation. Inherited or acquired deficiencies in Protein C can lead to an increased risk of thrombosis, a condition characterized by abnormal blood clot formation within blood vessels.

Meningococcal infections are caused by the bacterium Neisseria meningitidis, also known as meningococcus. These infections can take several forms, but the most common are meningitis (inflammation of the membranes surrounding the brain and spinal cord) and septicemia (bloodstream infection). Meningococcal infections are contagious and can spread through respiratory droplets or close contact with an infected person. They can be serious and potentially life-threatening, requiring prompt medical attention and treatment with antibiotics. Symptoms of meningococcal meningitis may include fever, headache, stiff neck, and sensitivity to light, while symptoms of septicemia may include fever, chills, rash, and severe muscle pain. Vaccination is available to prevent certain strains of meningococcal disease.

Idiopathic Thrombocytopenic Purpura (ITP) is a medical condition characterized by a low platelet count (thrombocytopenia) in the blood without an identifiable cause. Platelets are small blood cells that help your body form clots to stop bleeding. When you don't have enough platelets, you may bleed excessively or spontaneously, causing purpura, which refers to purple-colored spots on the skin that result from bleeding under the skin.

In ITP, the immune system mistakenly attacks and destroys platelets, leading to their decreased levels in the blood. This condition can occur at any age but is more common in children following a viral infection, and in adults after the age of 30-40 years. Symptoms may include easy or excessive bruising, prolonged bleeding from cuts, spontaneous bleeding from the gums or nose, blood blisters, and small red or purple spots on the skin (petechiae).

Depending on the severity of thrombocytopenia and the presence of bleeding symptoms, ITP treatment may include observation, corticosteroids, intravenous immunoglobulin (IVIG), or other medications that modify the immune system's response. In severe cases or when other treatments are ineffective, surgical removal of the spleen (splenectomy) might be considered.

Thrombotic thrombocytopenic purpura (TTP) is a rare but serious blood disorder. It's characterized by the formation of small blood clots throughout the body, which can lead to serious complications such as low platelet count (thrombocytopenia), hemolytic anemia, neurological symptoms, and kidney damage.

The term "purpura" refers to the purple-colored spots on the skin that result from bleeding under the skin. In TTP, these spots are caused by the rupture of red blood cells that have been damaged by the abnormal clotting process.

TTP is often caused by a deficiency or inhibitor of ADAMTS13, a protein in the blood that helps to regulate the formation of blood clots. This deficiency or inhibitor can lead to the formation of large clots called microthrombi, which can block small blood vessels throughout the body and cause tissue damage.

TTP is a medical emergency that requires prompt treatment with plasma exchange therapy, which involves removing and replacing the patient's plasma to restore normal levels of ADAMTS13 and prevent further clotting. Other treatments may include corticosteroids, immunosuppressive drugs, and rituximab.

Acne vulgaris is a common skin condition characterized by the formation of various types of blemishes on the skin, such as blackheads, whiteheads, papules, pustules, and cysts or nodules. These lesions typically appear on areas of the body that have a high concentration of sebaceous glands, including the face, neck, chest, back, and shoulders.

Acne vulgaris occurs when hair follicles become clogged with dead skin cells and excess oil (sebum) produced by the sebaceous glands. This blockage provides an ideal environment for bacteria, particularly Propionibacterium acnes, to multiply, leading to inflammation and infection. The severity of acne vulgaris can range from mild with only a few scattered comedones (blackheads or whiteheads) to severe cystic acne, which can cause significant scarring and emotional distress.

The exact causes of acne vulgaris are not fully understood, but several factors contribute to its development, including:

1. Hormonal changes during puberty, menstruation, pregnancy, or due to conditions like polycystic ovary syndrome (PCOS)
2. Genetic predisposition
3. Use of certain medications, such as corticosteroids and lithium
4. Excessive production of sebum due to overactive sebaceous glands
5. Accumulation of dead skin cells that clog pores
6. Bacterial infection (particularly Propionibacterium acnes)
7. Inflammation caused by the body's immune response to bacterial infection and clogged pores

Treatment for acne vulgaris depends on its severity and can include over-the-counter or prescription topical treatments, oral medications, chemical peels, light therapies, or even hormonal therapies in some cases. It is essential to seek professional medical advice from a dermatologist or healthcare provider to determine the most appropriate treatment plan for individual needs.

Sacroiliitis is a medical condition characterized by inflammation of one or both of the sacroiliac joints, which connect the spine's sacrum to the hip bones (ilium). This inflammation can cause pain in the lower back, hips, and legs, and may be accompanied by stiffness and difficulty walking. Sacroiliitis can be caused by various factors, including mechanical stress, trauma, infectious diseases, or underlying inflammatory conditions such as ankylosing spondylitis. The diagnosis of sacroiliitis typically involves a combination of physical examination, medical history, imaging studies, and laboratory tests to determine the underlying cause and appropriate treatment.

An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.

Thrombomodulin is a protein that is found on the surface of endothelial cells, which line the interior surface of blood vessels. It plays an important role in the regulation of blood coagulation (clotting) and the activation of natural anticoagulant pathways. Thrombomodulin binds to thrombin, a protein involved in blood clotting, and changes its function from promoting coagulation to inhibiting it. This interaction also activates protein C, an important anticoagulant protein, which helps to prevent the excessive formation of blood clots. Thrombomodulin also has anti-inflammatory properties and is involved in the maintenance of the integrity of the endothelial cell lining.

... may also lead to severe large vessel venous thrombosis if untreated in its early stages. Purpura fulminans ... Purpura fulminans is caused by defects in the protein C anticoagulant pathway. Identification of the cause of purpura fulminans ... Sometimes purpura fulminans has unknown cause. Regardless of the underlying cause of purpura fulminans, the mechanism of ... The distribution of purpura fulminans lesions may be different according to the underlying pathogenesis. Purpura fulminans in ...
Schulz SA, Edlich RF, Long WB, Gubler KD (October 12, 2022). Bronze MS (ed.). "Necrotizing fasciitis and purpura fulminans". ... wounding or trauma burns areas of extensive skin loss due to infection such as necrotizing fasciitis or purpura fulminans ...
Manifestation of purpura fulminans as it is usually associated with reduced protein C plasma concentrations of ... Some symptoms include blood clots primarily in the blood vessels of the limbs (purpura fulminans, disseminated intravascular ... This may manifest itself as purpura fulminans in newborn babies. There are two main types of protein C assays, activity and ...
Epidemic purpura fulminans associated with antecedent purulent conjunctivitis. Lancet 1987; 8562:757-761. The Brazilian ...
"Brazilian purpuric fever: epidemic purpura fulminans associated with antecedent purulent conjunctivitis." Lancet ii (1987): 757 ... purpura, vascular collapse and death. The overall patient fatality rate since the recognition of BPF is about 70%. The case ... or higher Abdominal pain and/or vomiting Development of petechiae and/or purpura No evidence of meningitis History of ...
Other symptoms include fever, purpura fulminans, and gastrointestinal or neurological disturbances. All these features are ...
Hulmani, M.; Alekya, P.; Kumar, V.J. (2017). "Indian tick typhus presenting as purpura fulminans with review on rickettsial ...
Smith, OP (1997). "Use of protein-C concentrate, heparin, and haemodiafiltration in meningococcus-induced purpura fulminans". ... thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, and malignant hypertension may mimic DIC but originate via ...
If a fetus is homozygous or compound heterozygous for the deficiency, there may be a presentation of purpura fulminans, severe ... However, warfarin treatment may produce paradoxical skin lesions similar to those seen in purpura fulminans. A variant of this ... Ceprotin is indicated in purpura fulminans and coumarin-induced skin necrosis in people with severe congenital protein C ...
Its natural counterpart, purpura fulminans, occurs in children who are homozygous for certain protein C mutations. After ...
... malignant chickenpox with purpura, postinfectious purpura, purpura fulminans, and anaphylactoid purpura. These syndromes have ... In contrast, malignant chickenpox with purpura is a grave clinical condition that has a mortality rate of greater than 70%. The ... Five major clinical syndromes have been described: febrile purpura, ... variable courses, with febrile purpura being the most benign of the syndromes and having an uncomplicated outcome. ...
Acute onset of vasculitis-like symptoms in small children or babies may instead be the life-threatening purpura fulminans, ... Possible signs and symptoms include: General symptoms: fever, unintentional weight loss Skin: palpable purpura, livedo ... It typically presents as palpable purpura. Conditions with leucocytoclasis mainly include hypersensitivity vasculitis (also ... Henoch-Schönlein purpura, and microscopic polyangiitis. Condition of some disorders have vasculitis as their main feature. The ...
... about his son who died from purpura fulminans at age 21 in October 2003 2013: L'Étoile et la Vieille, Editions Kero 2015: Jules ...
... but are distinct from purpura fulminans. They typically last for two to three weeks and can without specific treatment. The ...
Protein C deficiency may cause purpura fulminans, a severe clotting disorder in the newborn that leads to both tissue death and ...
... purpura, or purpura fulminans may indicate the presence of an infection.[citation needed] Previously, SIRS criteria had been ...
... purpura fulminans, cholesterol emboli, warfarin necrosis, ecthyma gangrenosum, and various hypercoagulable states. Rheumatoid ... One or more skin lesions including palpable purpura, ulcers, digital gangrene, and areas of necrosis occur in 69-89% of these ... Interruption of blood flow to other tissues in type I disease can cause cutaneous manifestations of purpura, blue discoloration ... "Meltzer's triad" of palpable purpura, joint pain, and generalized weakness occurs in ≈33% of patients presenting with type II ...
... which included a hyperbaric oxygen treatment system for patients with necrotizing fasciitis and purpura fulminans. He helped to ...
... purpura fulminans, sporotrichosis, Lyme disease, cowpox, and anthrax. Swanson, David L.; Vetter, Richard S. (2006). " ...
... colitis Fulminant pre-eclampsia Fulminant meningitis Purpura fulminans Fulminant hepatic venous thrombosis (Budd- ...
Thrombosis of lower extremities Superficial thrombophlebitis Redness in affected area Purpura fulminans Pulmonary embolism ...
The condition is related to purpura fulminans, a complication in infants with sepsis which also involves skin necrosis. These ...
Purpura fulminans (purpura gangrenosa) Purpura secondary to clotting disorders Purpuric agave dermatitis Raynaud phenomenon ... Henoch-Schönlein purpura (anaphylactoid purpura, purpura rheumatica, Schönlein-Henoch purpura) Hereditary hemorrhagic ... Doucas and Kapetanakis pigmented purpura Drug-induced purpura Drug-induced thrombocytopenic purpura Eczematid-like purpura of ... Solar purpura (actinic purpura, senile purpura) Stasis dermatitis (congestion eczema, gravitational dermatitis, gravitational ...
Purpura fulminans may also lead to severe large vessel venous thrombosis if untreated in its early stages. Purpura fulminans ... Purpura fulminans is caused by defects in the protein C anticoagulant pathway. Identification of the cause of purpura fulminans ... Sometimes purpura fulminans has unknown cause. Regardless of the underlying cause of purpura fulminans, the mechanism of ... The distribution of purpura fulminans lesions may be different according to the underlying pathogenesis. Purpura fulminans in ...
Background Purpura fulminans, first described by Guelliot in 1884, is a rare syndrome of intravascular thrombosis and ... Acute infectious purpura fulminans. Over time, the term purpura fulminans has come to be applied to cases of purpura fulminans ... Idiopathic purpura fulminans. Most of idiopathic purpura fulminans cases occur in children, and more than 90% are preceded by ... Neonatal purpura fulminans. Neonatal purpura fulminans occurs usually in patients with a deficiency of protein C. Protein C ...
... acute infectious purpura fulminans, idiopathic or acquired purpura fulminans, and neonatal purpura fulminans. Acute infectious ... Purpura fulminans in Adult. Print Images (27) Contributors: Jourdan Brandon MD, Asha Nanda MD, Philip I. Song MD, Susan Burgin ... See neonatal purpura fulminans for further discussion.. Codes. Copy. ICD10CM:. D65 - Disseminated intravascular coagulation [ ... Purpura fulminans (PF) is a severe, often fatal subtype of disseminated intravascular coagulation (DIC) that presents with ...
israelensis; both of these patients had purpura fulminans and multiorgan failure. Purpura fulminans should increase the ... Tirumala S, Behera B, Jawalkar S, Mishra PK, Patalay PV, Ayyagari S, et al. Indian tick typhus presenting as Purpura fulminans. ... Acute infectious purpura fulminans due to probable spotted fever. J Postgrad Med. 2014;60:198-9. DOIPubMedGoogle Scholar ... Purpura fulminans secondary to rickettsial infections: A case series. Indian Dermatol Online J. 2016;7:24-8. DOIPubMedGoogle ...
Background Purpura fulminans, first described by Guelliot in 1884, is a rare syndrome of intravascular thrombosis and ... Acute infectious purpura fulminans. Acute infectious purpura fulminans, the most common form of purpura fulminans, occurs ... Workup in purpura fulminans. Laboratory studies used in the workup of purpura fulminans include the following:. * Complete ... Management of purpura fulminans. Management of neonatal purpura fulminans may include the following:. * Immediate treatment ...
Copyright © 2023 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health. All rights reserved.. ...
Background Purpura fulminans, first described by Guelliot in 1884, is a rare syndrome of intravascular thrombosis and ... Acute infectious purpura fulminans. Over time, the term purpura fulminans has come to be applied to cases of purpura fulminans ... Idiopathic purpura fulminans. Most of idiopathic purpura fulminans cases occur in children, and more than 90% are preceded by ... Neonatal purpura fulminans. Neonatal purpura fulminans occurs usually in patients with a deficiency of protein C. Protein C ...
Background Purpura fulminans, first described by Guelliot in 1884, is a rare syndrome of intravascular thrombosis and ... Acute infectious purpura fulminans. Acute infectious purpura fulminans, the most common form of purpura fulminans, occurs ... Neonatal purpura fulminans. Neonatal purpura fulminans is associated with a hereditary deficiency of the natural anticoagulants ... Idiopathic purpura fulminans. Idiopathic or chronic purpura fulminans, first recognized in 1964, typically follows a bacterial ...
Evolution of purpura fulminans Damien Contou, Maud Pichon, Olivier Pajot, Gaëtan Plantefève ...
Purpura fulminans due to Staphylococcus aureus. Clin Infect Dis. 2005 Apr 1. 40(7):941-7. [QxMD MEDLINE Link]. ...
Clinical purpura fulminans in the absence of a positive blood culture; or ... which may progress to purpura fulminans. The clinical course can include hypotension, acute adrenal hemorrhage, multiorgan ...
... infants develop a life-threatening blood clotting disorder called purpura fulminans soon after birth. Purpura fulminans is ... Individuals who survive the newborn period may experience recurrent episodes of purpura fulminans. ...
Blood Disorders: focal vasiculitis, purpura fulminans, thromboembolic phenomena;. Underlying Disease States: diabetic ulcer, ...
Clinical evidence of invasive disease with purpura fulminans or petechiae, with no other apparent cause and with non- ... Invasive disease may progress rapidly to petechiae or purpura fulminans, shock and death. ... and purpura rash (18%). Meningitis was the most common clinical presentation among all serogroups, except for serogroup W-135 ...
Blood Disorders: focal vasiculitis, purpura fulminans, thromboembolic phenomena; Underlying Disease States: diabetic ulcer, ...
OMIM:176860: Thrombophilia due to protein C deficiency ; Purpura fulminans, neonatal. Thyroid peroxidase (P07202) (SMART). OMIM ...
OMIM:176860: Thrombophilia due to protein C deficiency ; Purpura fulminans, neonatal. Thyroid peroxidase (P07202) (SMART). OMIM ...
Infection-related disseminated intravascular coagulopathy or purpura fulminans.. Emboli. Emboli are particles that flow through ...
Anaphylactoid purpura Purpura fulminans Ehlers-Danlos syndrome. Prothrombin time, partial thromboplastin time. Bleeding time. ... strangulated hernia, anaphylactoid purpura, pulmonary disease, pancreatitis, lead poisoning, diabetes) Rule out other disease ...
Infrequent complications: Thrombocytopenia, hemorrhagic varicella, purpura fulminans, glomerulonephritis, myocarditis, ...
Purpura fulminans complicating scrub typhus and acute hepatitis E coinfection. Dhriti Sundar Das, Rashmi Ranjan Mohanty, ...
In all cases, red or purple patches on the skin that do not disappear when pressure is applied indicate purpura fulminans. It ...
Neonatal purpura fulminans caused by Acinetobacter… December 30, 2021 *An unusual case of recurrent chemotherapy recall ... Hypergammaglobulinemic purpura of Waldenström is a rare syndrome characterized by recurrent episodes of purpura occurring ... thrombocytopenic purpura, Henoch-Schonlein purpura, pigmentary purpuric dermatosis, monoclonal gammopathy, and lymphoma. ... As we know, purpura is one of the clinicopathologic entities which presents as the initial manifestation of a variety of ...
Purpura Fulminans in a Patient with Rheumatoid Arthritis. Ting Xiao, Zhe Guo, Jian Wu, Chun-Lin Zhou, Hong-Duo Chen ...
Acute infectious purpura fulminans (AIPF) is the most severe complication of septic shock, associated with disseminated ... Acute Infectious Purpura Fulminans in a Living Renal Transplant Patient with Perioperative Diabetic Foot Ulcer ...
Complications such as renal failure, pneumonia, and purpura fulminans may rarely occur.. Males are more often infected than ...
Shenoy R, Nanjappa S, Eaton K, Prieto-Granada C, Messina J, Greene J. Purpura Fulminans: A Case Report and Review of All Causes ...
Marys Health Center Department of Internal Medicine Intern Case Presentation: Purpura Fulminans in Pneumococcal Sepsis ...
  • Neonatal purpura fulminans occurs usually in patients with a deficiency of protein C. Protein C deficiency is usually inherited in an autosomal dominant manner, with heterozygous carriers often remaining asymptomatic until later in life, when they become very susceptible to venous thromboembolism. (medscape.com)
  • Within the first 72 hours after birth, a neonate with neonatal purpura fulminans exhibits purpuric lesions over many different skin sites, including the perineal region, the flexor surface of the thighs, and abdominal skin. (medscape.com)
  • PF can be categorized into 3 types: acute infectious purpura fulminans, idiopathic or acquired purpura fulminans, and neonatal purpura fulminans . (logicalimages.com)
  • See neonatal purpura fulminans for further discussion. (logicalimages.com)
  • Neonatal purpura fulminans and transient protein C deficiency. (bmj.com)
  • Sen K, Roy A. Management of neonatal purpura fulminans with severe protein C deficiency. (medscape.com)
  • Neonatal purpura fulminans is associated with a hereditary deficiency of the natural anticoagulants protein C and protein S, as well as antithrombin III (ATIII). (medscape.com)
  • Purified plasma protein C concentrate has been successfully used to treat patients with thrombotic episodes in neonatal purpura fulminans. (medscape.com)
  • [ 4 ] The complete lack of plasma protein C activity causes neonatal purpura fulminans, which is characterized by sudden onset of widespread purpuric lesions that progress to gangrenous necrosis and is associated with DIC. (medscape.com)
  • Diagnosis and management of neonatal purpura fulminans. (scpcd.org)
  • Some infants who do not have neonatal purpura fulminans but still have low levels of protein C (5% to 20%) often have a tendency to clot excessively at an early age. (ihtc.org)
  • Homozygous deficiency of protein S can cause neonatal purpura fulminans that is clinically indistinguishable from that caused by homozygous deficiency of protein C. (msdmanuals.com)
  • In cases of severe inheritable protein C deficiency, purpura fulminans with disseminated intravascular coagulation manifests within a few hours or days after birth. (wikipedia.org)
  • The cardinal features of purpura investigations are the same as those of disseminated intravascular coagulation: prolonged plasma clotting times, thrombocytopenia, reduced plasma fibrinogen concentration, increased plasma fibrin-degradation products and occasionally microangiopathic haemolysis. (wikipedia.org)
  • Purpura fulminans (PF) is a severe, often fatal subtype of disseminated intravascular coagulation (DIC) that presents with extensive tissue thrombosis and widespread skin necrosis. (logicalimages.com)
  • Purpura fulminans is a rare syndrome of intravascular thrombosis and hemorrhagic infarction of the skin that is rapidly progressive and is accompanied by vascular collapse and disseminated intravascular coagulation. (medscape.com)
  • In neonates, SCPCD can manifest, as early as 2-12 hours after birth, as purpura fulminans with necrosis of the skin, disseminated intravascular coagulation, arterial and venous thrombosis . (scpcd.org)
  • Disseminated intravascular coagulation is also associated with widespread purpura, as well as ecchymoses or bruising and bleeding, and has several potential causes. (dermatologytimes.com)
  • however, purpura fulminans will rapidly progress to necrosis whereas other purpuric rashes do not. (wikipedia.org)
  • The initial appearance of purpura fulminans lesions is of well-demarcated erythaamatous lesions which progress rapidly to develop irregular central areas of blue-black haemorrhagic necrosis. (wikipedia.org)
  • The purpura usually begins suddenly, 7-10 days after the onset of the precipitating infection, with the development of progressively enlarging, well-demarcated purplish areas of hemorrhagic cutaneous necrosis with deranged coagulation factors. (medscape.com)
  • Coumadin necrosis (warfarin necrosis) - Purpura from warfarin is more prominent on fatty areas such as the breasts, buttocks, and thighs, while PF is usually more extensive. (logicalimages.com)
  • Neonates with homozygous Protein C deficiency (Protein C levels close to zero) present with an often fatal syndrome of purpura fulminans with spreading skin necrosis, thrombosis and disseminated intravascular coagulation (DIC). (clinlabnavigator.com)
  • Purpura fulminans is caused by defects in the protein C anticoagulant pathway. (wikipedia.org)
  • In some cases, a combination of sepsis and a partial congenital defect in the protein C anticoagulant pathway initiates purpura fulminans. (wikipedia.org)
  • In rare instances, purpura fulminans is an autoimmune manifestation against protein C or protein S after normally benign infections, such as chicken pox. (wikipedia.org)
  • Regardless of the underlying cause of purpura fulminans, the mechanism of disease is similar with deficiency in protein C concentration or decrease in protein C activity which promotes blood clotting (thrombosis). (wikipedia.org)
  • Protein C and protein S levels in two patients with acquired purpura fulminans. (medscape.com)
  • In severe cases of protein C deficiency, infants develop a life-threatening blood clotting disorder called purpura fulminans soon after birth. (medlineplus.gov)
  • Even if the most frequent cause of purpura fulminans in neonates is severe acute infections and associated sepsis, Severe Congenital Protein C Deficiency (SCPCD) can also lead to this disorder, with lesions appearing as early as 2-12 hours after birth. (scpcd.org)
  • Purpura fulminans is an acute, often fatal, thrombotic disorder which manifests as blood spots, bruising and discolouration of the skin resulting from coagulation in small blood vessels within the skin and rapidly leads to skin necrosis and disseminated intravascular coagulation. (wikipedia.org)
  • Purpura fulminans is a presenting feature of severe acute sepsis, such as Neisseria meningitidis, Streptococcus pneumoniae, Group A and B Streptococci, and less commonly with Haemophilus influenzae, Staphylococcus aureus, or Plasmodium falciparum (malaria) infections, particularly in individuals with asplenia. (wikipedia.org)
  • Patients who present with acute infectious purpura fulminans should receive broad-spectrum intravenous antibiotic therapy with activity against a variety of pathogens, including Neisseria meningitidis, streptococci, and methicillin-resistant Staphylococcus aureus (MRSA). (medscape.com)
  • Purpura fulminans (PF) is a potentially fatal uncommon disorder of intravascular thrombosis and is clinically characterized by rapidly progressive hemorrhagic infarction of the skin. (e-ijd.org)
  • thrombosis (purpura fulminans, peripheral acrocyanosis, gangrene in extremities). (who.int)
  • Most of idiopathic purpura fulminans cases occur in children, and more than 90% are preceded by infection (commonly varicella or streptococcal infection). (medscape.com)
  • Massive infectious soft-tissue injury: diagnosis and management of necrotizing fasciitis and purpura fulminans. (medscape.com)
  • There are warning signs that purpura can be potentially life threatening, says Roderick Hay, D.M., FRCP, a consultant dermatologist with a special interest in infectious disease. (dermatologytimes.com)
  • Individuals who survive the newborn period may experience recurrent episodes of purpura fulminans. (medlineplus.gov)
  • Haemorrhage into the necrotic skin causes purpura fulminans lesions to become painful, dark and raised, sometimes with vesicle or blister (bulla) formation. (wikipedia.org)
  • The distribution of purpura fulminans lesions may be different according to the underlying pathogenesis. (wikipedia.org)
  • Lesions begin as erythematous macules that progress within hours to sharply defined areas of purpura. (medscape.com)
  • A majority of the patients manifest skin lesions, sometimes leading to PURPURA FULMINANS. (bvsalud.org)
  • We report a series of 5 case-patients who had Israeli spotted fever, of whom 2 had purpura fulminans and died. (cdc.gov)
  • In North African pura fulminans is rapidly fatal ( 1 , 2 ). (who.int)
  • Dr. Roderick Hay outlines what you need to know about potentially life-threatening conditions involving purpura. (dermatologytimes.com)
  • During a session on life threatening diseases in dermatology held at the European Academy of Dermatology and Venerology Congress last September in Paris, Dr. Hay outlined some potentially life-threatening conditions in which purpura is involved and which are often related to infections. (dermatologytimes.com)
  • Purpura fulminans in severe sepsis typically develops in the distal extremities and progresses proximally or appears as a generalised or diffuse rash affecting the whole body surface. (wikipedia.org)
  • Over time, the term purpura fulminans has come to be applied to cases of purpura fulminans that occur in the face of overwhelming sepsis (ie, sepsis-associated fulminans). (medscape.com)
  • Meningococcal disease manifests most commonly as meningitis and/or meningococcemia that may progress rapidly to purpura fulminans, shock, and death. (cdc.gov)
  • In most cases, differential diagnoses may be distinguished from purpura fulminans by other clinical and laboratory findings. (wikipedia.org)
  • Palpable petechiae and purpura are a result of either perivascular inflammation (vasculitis) or infection. (wikem.org)
  • For children with fever and petechiae/purpura consider using the Barts Health NHS Trust guideline for workup. (wikem.org)
  • In the dermis, this manifests as purpura fulminans. (ajops.com)
  • Purpura fulminans: recognition, diagnosis and management. (scpcd.org)
  • Laboratory studies are the primary diagnostic tools for working up purpura fulminans. (medscape.com)
  • There are three main causes of purpura: Disorders of platelets, disorders of coagulation and vasculitis. (dermatologytimes.com)
  • Emergency management of purpura and vasculitis, including purpura fulminans. (booksca.ca)
  • Identification of the cause of purpura fulminans often depends on the patient's age and circumstances of presentation. (wikipedia.org)
  • Complications such as renal failure, pneumonia, and purpura fulminans may rarely occur. (logicalimages.com)
  • Staphylococcus aureus has been associated with purpura fulminans with accompanying toxic shock syndrome. (medscape.com)
  • Lesion associated with purpura fulminans in an adult patient. (medscape.com)
  • Purpura fulminans: a disease best managed in a burn center. (medscape.com)
  • Meningococcal disease carries a mortality rate of around 10 per cent in developed countries and of those who survive septic shock with purpura fulminans, eight per cent require digital and/or limb amputation. (ajops.com)
  • In early purpura fulminans, lesion progression correlates with the histological appearance of blockage of small skin blood vessels with blood clots causing capillary dilation and congestion with red blood cells. (wikipedia.org)
  • Purpura occurs when blood escapes from the vascular system into the skin. (dermatologytimes.com)
  • Infection -related disseminated intravascular coagulopathy or purpura fulminans. (dermnetnz.org)
  • The first of these is purpura fulminans, a rare and severe complication of meningococcal septicaemia which is caused by Neisseria meningitidis. (dermatologytimes.com)
  • Purpura fulminans is characterized by the formation of blood clots in the small blood vessels throughout the body. (medlineplus.gov)
  • Debridement of infarcted musculature and 19 per cent TBSA purpura fulminans resulted in near-circumferential soft-tissue loss to both lower limbs also extending over the bilateral thighs, forearms, abdomen and left hand. (ajops.com)