Quassia
Simaroubaceae
Antiulcerogenic activity of four extracts obtained from the bark wood of Quassia amara L. (Simaroubaceae). (1/3)
Quassia amara L., a neotropical forest shrub of the Simaroubaceae family, is widely used in Caribbean folk medicine and in some northern states of Brazil for the treatment of gastric ulcers. This plant is a source of numerous compounds including both beta-carbonile and cantin-6 alkaloids as well as, primarily, the bitter compounds known as quassinoids. We analyzed the possible antiulcerogenic activities of four extracts of different polarities: 70% ethanol (70% EtOH), 100% EtOH, 100% dichloromethane (DCM), and 100% hexane (HEX) obtained from Quassia amara bark. All extracts, administered at doses of 5000 mg/kg orally and 1000 mg/kg intraperitoneally, caused neither toxicity or death. In the indomethacin/bethanechol-induced gastric ulcer, 70% EtOH, 100% EtOH, DCM and HEX extracts, 100 mg/kg, p.o., inhibited the gastric ulcer (22.5, 23.4, 50.5, 46.8%, respectively). 70% EtOH, 100% EtOH, DCM, and HEX extracts reduced the gastric injury induced by the hypothermic restraint-stress test in mice (70.7, 80, 60, 82.7%, respectively). In the pylorus ligature of the mouse stomach, following pre-treatment with a single intraduodenal administration of 100 mg/kg of each extract, only 70% EtOH did not change the biochemical parameters of gastric juice. 100% EtOH, DCM and HEX extracts presented decreased gastric juice content, increased pH values and decreased acid output. We also determined the antiulcerogenic activity on HCl-EtOH-induced gastric ulcers in mice at four doses (25, 50, 75, 100 mg/kg, p.o.), then evaluated the possible dose-dependent relation and calculated the ED50 values. Except for 70% EtOH at a dose of 25 mg/kg, the other extracts showed significantly activity (p<0.05). The free mucous amount in the gastric stomach content was also evaluated. All extracts showed significant increases (p<0.05) of free mucous. This effect was abolished when the animals were pre-treated with indomethacin. Prostaglandin synthesis was evaluated by the administration of HEX extracts by the oral route (100 mg/kg). Prostaglandin synthesis was significantly, increased by 52.3% (p<0.05), and this effect was abolished with prior administration of indomethacin. We concluded that Quassia amara is a probable source for a new drug to treat gastric ulcers, and the mechanism of its activity relates to cytoprotective factors, such as mucous and prostaglandins, but there is still the possibility that antisecretory activity is involved in its antiulcerogenic effect. (+info)Induction of murine embryonic stem cell differentiation by medicinal plant extracts. (2/3)
(+info)Antiulcerogenic effects and possible mechanism of action of Quassia amara (L. Simaroubaceae) extract and its bioactive principles in rats. (3/3)
The effects of Quassia amara extract (Q. amara) and its bioactive principles-quassin and 2-methoxycanthin-6-one on gastric ulceration were studied in albino rats. Q. amara (200-800 mg/kg p.o.; 5-20 mg/kg i.p) and 2-methoxycanthin-6-one (12.5, 25.0 and 50.0 mg/kg p.o; 1, 2 and 4 mg/kg i.p) but not quassin (12.5, 25.0 and 50 mg/kg p.o; 1, 2 and 4 mg/kg i.p) significantly inhibited gastric ulceration induced by indomethacin (40mg/kg). Administration of Q. amara (800 mg/kg p.o and 20 mg/kg i.p) and 2-methoxycanthin-6-one (12.5 mg/kg p.o; 4 mg/kg i.p) caused between 77%-85% cytoprotection against indomethacin (40 mg/kg, i.p) - induced gastric ulceration. Quassin did not cause any significant change in indomethacin-induced gastric ulceration. The inhibition of gastric ulceration produced by Q. amara and 2-methoxycanthin-6 one was accompanied by significant dose-dependent decreases (P< 0.01) in total gastric acidity. To investigate the probable mechanism of action, the individual effects of the extract and its principles alone and in combination with histamine (1 mg/kg) or cimetidine (0.12 mg/kg) on gastric acid secretion in situ were studied. Q. amara (20 mg/kg) and 2-methoxycanthin-6-one (4 mg/kg) but not quassin significantly (P< 0.01) inhibited the basal and histamine-induced gastric acid secretion. Inhibition of gastric acid secretion by Q. amara and 2-methoxycanthin-6-one was accentuated by cimetidine. The results suggest that Q. amara and its bioactive principle, 2-methoxycanthin-6-one possess antiulcer activity probably acting via histamine H2 receptor. This could be a potential source of potent and effective antiulcer agents. (+info)Quassia is not typically defined in a medical context as a treatment or diagnosis. Instead, it refers to the bark or wood of the Quassia tree (Quassia amara), which has been used in traditional medicine for its bitter taste and potential medicinal properties.
The primary active compounds found in Quassia are quassinoids, which have been studied for their potential insecticidal, antimalarial, and anticancer activities. However, it's important to note that the use of Quassia as a medicine is not well-studied in clinical trials, and its safety and efficacy have not been fully established by regulatory agencies such as the US Food and Drug Administration (FDA).
Therefore, while Quassia may be used in some traditional or alternative medicine practices, it should not be considered a standard medical treatment without further research and evaluation.
Simaroubaceae is not a medical term, but a taxonomic category in botany. It refers to a family of plants, also known as the quassia family. The plants in this family are primarily tropical trees and shrubs, found in Africa, Asia, and America. Some species have been used in traditional medicine for their bitter taste, which is thought to stimulate digestion and appetite. However, it's important to note that while some Simaroubaceae plants have medicinal properties, the family itself does not have a specific medical definition or application.
Quassinoids are a group of naturally occurring compounds that are found in various plants, including the bark of Quassia amara, a tree native to South America. Quassins, one type of quassinoid, have been studied for their potential medicinal properties, particularly as antimalarial and anticancer agents. They are known to interact with cell membranes and can affect the growth and multiplication of certain types of cells. However, more research is needed to fully understand their mechanisms of action and potential therapeutic uses. It's important to note that quassins can also be toxic in high concentrations, so further studies are necessary to determine safe and effective dosages for medical use.
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Amara19
- some botanists treat it as consisting of only one species, Quassia amara from tropical South America, while others treat it in a wide circumscription as a pantropical genus containing up to 40 species of trees and shrubs. (wikipedia.org)
- He discovered the medicinal properties of the bark of Quassia amara. (wikipedia.org)
- Quassia amara L. Quassia arnhemensis Craven & Dunlop Quassia baileyana (Oliv. (wikipedia.org)
- Quassia amara L. (funet.fi)
- Quassia Amara is available in all the potencies, formats and brands specified below. (abchomeopathy.com)
- For uses of Quassia Amara 30C see the main Quassia Amara page for materia medica from Boericke, Clarke and T.F. Allen. (abchomeopathy.com)
- Quassia Amara is not available from Boiron. (abchomeopathy.com)
- 100% pure amargo bark (Quassia amara). (raintree.com)
- Quassia Herbal Extract Tincture, Super-Concentrated Wildcrafted Quassia (Quassia amara) Dried Bar. (herb-era.com)
- Quassia (Quassia amara), also called Suriname wood, is a bitter tonic that increases salivary secretions and excites the appetite. (herb-era.com)
- Infoteca-e: Quassia amara: Quina. (embrapa.br)
- Originating from South America, Quassia Chips are made from the bark of the Quassia amara tree, which has been used medicinally for centuries. (herbtobody.com)
- This is a print of a Quassia Wood (Quassia Amara) plant based on vintage botanical artwork. (printapatent.com)
- The plant named after Graman Quassi is called Quassia amara. (africarebirth.com)
- One of his remedies was a bitter tea that he used to treat infections by intestinal parasites, and this concoction was based on the plant Quassia Amara , which Carl Linnaeus named after him, as the discoverer of its medicinal properties. (africarebirth.com)
- Although the timing and location of Quassi's discoveries aren't precise, researchers think he probably discovered the properties of Quassia amara before 1730. (africarebirth.com)
- What are the Uses and Benefits of Quassia Amara- Herb? (planetayurveda.com)
- Introduction Quassia amara is a species of genus Quassia. (planetayurveda.com)
- Home Herbs Natural Remedies Hombre grande Evergreen Herbs Quassia Chips Hombre Grande - Quassia Amara, Bitterwood, Hombre Grande, Amargo, Bitter-ash, Cuasia - Resealable Stand Up Pouch to Ensure Freshness! (sbstotalhealth.com)
Bark6
- The quassia tree grows from 50 to 100 feet high, with smooth, gray bark. (biocompletenaturaldiet.com)
- Ages ago, the West Indians used the bark of quassia to treat stomach upset, fever, and to induce appetite when ill. (biocompletenaturaldiet.com)
- The traditional method of making Quassia Chips consists of first boiling the Quassia bark for extended periods of time and then drying it in the sun. (herbtobody.com)
- type":"article-journal","title":"Phytochemical profile and antimicrobial potential of methanolic extracts of bark and leaf of Quassia indica (Gaertn","DOI":null,"author":[{"given":"P.","family":"Anusha"},{"given":"B.R.","family":"Sudha"}],"issued":{"date-parts":["2017"]},"container-title":"Nooteb. (lekovitesirovine.rs)
- The bark is used to make teas, capsules or tinctures, depending on what you are treating as quassia has many uses. (sbstotalhealth.com)
- Other common names that aregiven to the wood of the Quassia tree are: bitter wood, ash, bark,quasia and cuassia. (mexgrocer.com)
Simaroubaceae1
- Quassia (/ˈkwɒʃə/ or /ˈkwɒʃiə/) is a plant genus in the family Simaroubaceae. (wikipedia.org)
Shrub2
- This is a vintage style Botanical illustration of a tropical flowering evergreen shrub called bitter quassia, using gouache on paper. (marcybrennan.com)
- Quassia is a shrub and grows to around 3 meters tall-and occasionally-up to 8 meters tall. (sbstotalhealth.com)
Genus3
- Accepted species of the genus, as of February 2021, are: Quassia africana (Baill. (wikipedia.org)
- The plant is a species in the genus Quassia, with some botanists treating it as the sole species in the genus. (africarebirth.com)
- He was a Surinamese healer, botanist, slave, and later freedman of the 18th century, who is today best known for having given his name to the plant genus Quassia. (africarebirth.com)
Cuasia2
- Cuasia - Quassia - 8 oz. (sbstotalhealth.com)
- El Guapo te ofrece la corteza del arbol de Cuasia en un paquetepractico con el cual podras prepararte y tomar una taza de estepopular remedio. (mexgrocer.com)
Indica1
- Quassia indica (Gaertn. (wikipedia.org)
Undulata4
- Quassia undulata (Guill. (wikipedia.org)
- Qualitative and quantitative phytochemical evaluation of Quassia undulata (Guill. (lekovitesirovine.rs)
- This study investigated solvent effects on the phytochemical composition of Quassia undulata leaves a medicinal plant used in treating arrays of diseases including fever and cough. (lekovitesirovine.rs)
- The presence of these secondary metabolites might justify the ethnomedicinal uses of Quassia undulata leaves as their bioactivity has been found to be dependent on the solvent used for extraction. (lekovitesirovine.rs)
Wormwood1
- It is blended with aromats including wormwood, quassia and rosemary, to produce a fabulous Vermouth. (wine-pages.com)
West Indies1
- The Quassia is a tree cultivated in the West Indies and the parts adjacent. (usf.edu)
Chips10
- The West Indians also prepared more potent mixtures by adding finely chopped chips of the quassia wood and steeping them in water. (biocompletenaturaldiet.com)
- Quassia chips are used to discourage thumb sucking among children. (medicinalherbinfo.org)
- Unlike Capsicum, which is sometimes used in preparations to discourage thumb sucking, tea of quassia chips will not burn the eyes when the child happens to come in such contact. (medicinalherbinfo.org)
- Quassia chips, an intense bitter, is used in aperitifs and sometimes as a substitute for hops in making beer. (medicinalherbinfo.org)
- Steep 1 pint of quassia chips for 1 hour or more in a gallon of hot water. (medicinalherbinfo.org)
- To repel gnats, put a handful of Quassia chips into a bowl of cold water, leaving for 12 hours or longer. (medicinalherbinfo.org)
- Treat yourself to a pleasant and unique herb-based experience with Quassia Chips. (herbtobody.com)
- Quassia Chips have a pasty, soft texture, and their unique, savoury flavour adds an interesting twist to salads, main dishes, and desserts. (herbtobody.com)
- Overall, Quassia Chips offer a delicious and accessible way to explore something new. (herbtobody.com)
- Where to buy quassia chips? (city-data.com)
Evergreen1
- Quassia is an evergreen tree originating from tropical America and theCarribean, that can grow up to 100 feet high. (mexgrocer.com)
Quassi1
- The generic name Quassia is derived from a man named Quassi of Surinam, who employed the wood with uncommon success as a secret remedy in the malignant endemic fevers which frequently prevails in Surinam. (medicinalherbinfo.org)
Surinam1
- See [ maps ] Surinam Quassia wood? (funet.fi)
Parasites1
- Quassia continues to be used in industrially produced medicines against intestinal parasites today. (africarebirth.com)
Medicinally1
- Quassia was first used medicinally by the Amerindians and was introduced into Europe around the middle of the 18th century. (herb-era.com)
Plant1
- An old-fashioned plant spray to drive off plant lice was made with a strong decoction of Quassia mixed with liquid soap. (medicinalherbinfo.org)
Tonic1
- Water left standing overnight in a cup made from quassia wood becomes a weak infusion suitable as a bitter tonic for the stomach. (medicinalherbinfo.org)
Wood2
- They were a sort of wooden cup or goblet, make of Quassia wood, for the purpose of drinking out of, to obtain the properties of the wood, which is so bitter, and yields its properties so readily to water, that if water is allowed to remain a few minutes in the cup, it will become quite bitter. (medicinalherbinfo.org)
- quassia wood in 1 cup boiling water. (medicinalherbinfo.org)
Capsules1
- Quassia is generally prepared in capsules, teas or tinctures. (sbstotalhealth.com)
Insecticides1
- Quassia is a common component of insecticides. (medicinalherbinfo.org)
Lotions1
- Quassia is used in hair lotions. (medicinalherbinfo.org)
Pets2
- Quassia may increase appetite for underweight pets, and improve digestion by increasing salivary and gastric secretions, and peristalsis of the stomach. (biocompletenaturaldiet.com)
- Quassia should not be used for pregnant or nursing pets. (biocompletenaturaldiet.com)
Known as quassia wood1
- Picrasma javanica, also known as quassia wood, is a medium-sized tree that belongs to the quassia (Simaroubaceae) family of flowering plants. (naturalnews.com)
Picrasma1
- The botanical name of quassia is Picrasma excelsa. (gpatindia.com)
Bitterness2
- The intense bitterness of quassia is thought to symbolize a cleansing or purifying aspect. (mysticsoulritualshop.com)
- Some practitioners believe that the bitterness of quassia can help sharpen intuitive abilities. (mysticsoulritualshop.com)
Botanists1
- In the 18th century, European explorers and botanists brought quassia back to Europe. (mysticsoulritualshop.com)
WOOD2
- The biological source of quassia is dried stem of wood. (gpatindia.com)
- What are some of the health benefits of quassia wood? (naturalnews.com)
Lice1
- People use quassia for stomach and intestinal problems, diabetes, lice, skin conditions, and many other conditions, but there is no good scientific evidence to support most uses. (veganchoicefoods.com)
Family1
- Help support Wordnik (and make this page ad-free) by adopting the word quassia family . (wordnik.com)
Site1
- There's a cool new site in Beta called Quassia where you can get a lot of backlinks to your site - which you probably already know are like pagerank gold! (lisaangelettieblog.com)
Make1
- We recommend doing a skin test to make sure you are not allergic if you plan on using Quassia topically. (mysticsoulritualshop.com)