A plant genus of the APOCYNACEAE or dogbane family. Alkaloids from plants in this genus have been used as tranquilizers and antihypertensive agents. RESERPINE is derived from R. serpentina.

Heterologous expression of a Rauvolfia cDNA encoding strictosidine glucosidase, a biosynthetic key to over 2000 monoterpenoid indole alkaloids. (1/23)

Strictosidine glucosidase (SG) is an enzyme that catalyses the second step in the biosynthesis of various classes of monoterpenoid indole alkaloids. Based on the comparison of cDNA sequences of SG from Catharanthus roseus and raucaffricine glucosidase (RG) from Rauvolfia serpentina, primers for RT-PCR were designed and the cDNA encoding SG was cloned from R. serpentina cell suspension cultures. The active enzyme was expressed in Escherichia coli and purified to homogeneity. Analysis of its deduced amino-acid sequence assigned the SG from R. serpentina to family 1 of glycosyl hydrolases. In contrast to the SG from C. roseus, the enzyme from R. serpentina is predicted to lack an uncleavable N-terminal signal sequence, which is believed to direct proteins to the endoplasmic reticulum. The temperature and pH optimum, enzyme kinetic parameters and substrate specificity of the heterologously expressed SG were studied and compared to those of the C. roseus enzyme, revealing some differences between the two glucosidases. In vitro deglucosylation of strictosidine by R. serpentina SG proceeds by the same mechanism as has been shown for the C. roseus enzyme preparation. The reaction gives rise to the end product cathenamine and involves 4,21-dehydrocorynantheine aldehyde as an intermediate. The enzymatic hydrolysis of dolichantoside (Nbeta-methylstrictosidine) leads to several products. One of them was identified as a new compound, 3-isocorreantine A. From the data it can be concluded that the divergence of the biosynthetic pathways leading to different classes of indole alkaloids formed in R. serpentina and C. roseus cell suspension cultures occurs at a later stage than strictosidine deglucosylation.  (+info)

Potential active-site residues in polyneuridine aldehyde esterase, a central enzyme of indole alkaloid biosynthesis, by modelling and site-directed mutagenesis. (2/23)

In the biosynthesis of the antiarrhythmic alkaloid ajmaline, polyneuridine aldehyde esterase (PNAE) catalyses a central reaction by transforming polyneuridine aldehyde into epi-vellosimine, which is the immediate precursor for the synthesis of the ajmalane skeleton. The PNAE cDNA was previously heterologously expressed in E. coli. Sequence alignments indicated that PNAE has a 43% identity to a hydroxynitrile lyase from Hevea brasiliensis, which is a member of the alpha/beta hydrolase superfamily. The catalytic triad, which is typical for this family, is conserved. By site-directed mutagenesis, the members of the catalytic triad were identified. For further detection of the active residues, a model of PNAE was constructed based on the X-ray crystallographic structure of hydroxynitrile lyase. The potential active site residues were selected on this model, and were mutated in order to better understand the relationship of PNAE with the alpha/beta hydrolases, and as well its mechanism of action. The results showed that PNAE is a novel member of the alpha/beta hydrolase enzyme superfamily.  (+info)

Probing suggested catalytic domains of glycosyltransferases by site-directed mutagenesis. (3/23)

The plant enzyme arbutin synthase isolated from cell suspension cultures of Rauvolfia serpentina and heterologously expressed in Escherichia coli is a member of the NRD1beta family of glycosyltransferases. This enzyme was used to prove, by site-directed mutagenesis, suggested catalytic domains and reaction mechanisms proposed for enzyme-catalyzed glycosylation. Replacement of amino acids far from the NRD domain do not significantly affect arbutin synthase activity. Exchange of amino acids at the NRD site leads to a decrease of enzymatic activity, e.g. substitution of Glu368 by Asp. Glu368, which is a conserved amino acid in glycosyltransferases located at position 2 and is important for enzyme activity, does not serve as the nucleophile in the catalytic centre as proposed. When it is replaced by Ala, the resulting mutant enzyme E368A exhibits comparable activity as found for E368D in respect to vanillin. Enzyme activities of wild-type and E368A towards several substrates were not affected at the same level. His360 at position 1 of NRD1beta glycosyltransferases occupies a more crucial role as expected. When it is exchanged against other basic amino acids such as Lys or Arg the enzyme activity decreases approximately 1000-fold. Replacement of His360 by Glu leads to a mutant enzyme (H360E) with an approximately 4000-fold lower activity compared with the wild-type. This mutein still produces a beta-glucoside, not an alpha-glucoside and therefore indicates that generation of the typical E-E motif of NRD1alpha glycosyltransferases does not convert a NRD1beta enzyme into a NRD1alpha enzyme. The presented data do not support several suggestions made in the literature about catalytic amino acids involved in the glycosyltransfer reaction.  (+info)

Rauwolfia serpentina; prolonged use in elderly hypertensive patients. (4/23)

In a group of older, arteriosclerotic hypertensive patients treated with an extract of Rauwolfia over a long period, a mild hypotensive effect was noted after weeks, or occasionally months, of therapy. No dramatic responses were seen, but the so-called "tranquilizing" effect was readily apparent and was appreciated by the patients. Side effects were usually relatively minor, were transient and rarely necessitated stopping the drug.  (+info)

Antihistaminase activity of serpentine. (5/23)

Serpentine, an alkaloid of Rauwolfia serpentina, specifically potentiates histamine responses of guinea-pig ileum, uterus, and tracheal chain. It also inhibits histaminase in vitro. Its antihistaminase activity is equivalent to that of aminoguanidine.  (+info)

NEWER DRUGS IN THE TREATMENT OF HYPERTENSION. (6/23)

The treatment of essential hypertension still consists of the judicious combination of two or more agents. The chemical nature, pharmacology, side effects and relative merits of two groups of drugs are reviewed: (1) agents interfering with the synthesis, storage and release of endogenous catecholamines and (2) oral diuretic agents. Rauwolfia compounds, bretylium tosylate, guanethidine, alpha-methyldopa and pargyline hydrochloride comprise the first group; thiazide derivatives, phthalimidine compounds and spironolactones constitute the second. Guanethidine is the most potent and most extensively used agent in the second group. While not yet fully assessed, alpha-methyldopa and pargyline hydrochloride are useful in selected cases. The intrinsic hypotensive properties of oral diuretics, their low incidence of side effects and their ability to potentiate the more potent agents make them useful adjuncts in the long-term treatment of hypertension. Attention is drawn to the potential diabetogenic and hyperuricemic effects of the thiazides and phthalimidine compounds.  (+info)

Vinorine synthase from Rauvolfia: the first example of crystallization and preliminary X-ray diffraction analysis of an enzyme of the BAHD superfamily. (7/23)

Crystals of vinorine synthase (VS) from medicinal plant Rauvolfia serpentina expressed in Escherichia coli have been obtained by the hanging-drop technique at 305 K with ammonium sulfate and PEG 400 as precipitants. The enzyme is involved in the biosynthesis of the antiarrhythmic drug ajmaline and is a member of the BAHD superfamily of acyltransferases. So far, no three-dimensional structure of a member of this enzyme family is known. The crystals belong to the space group P2(1)2(1)2(1) with cell dimensions of a=82.3 A, b=89.6 A and c=136.2 A. Under cryoconditions (120 K), a complete data set up to 2.8 A was collected at a synchrotron source.  (+info)

Crystallization and preliminary X-ray crystallographic analysis of strictosidine synthase from Rauvolfia: the first member of a novel enzyme family. (8/23)

Strictosidine synthase is a central enzyme involved in the biosynthesis of almost all plant monoterpenoid indole alkaloids. Strictosidine synthase from Rauvolfia serpentina was heterologously expressed in Escherichia coli. Crystals of the purified recombinant enzyme have been obtained by the hanging-drop technique at 303 K with potassium sodium tartrate tetrahydrate as precipitant. The crystals belong to the space group R3 with cell dimensions of a=b=150.3 A and c=122.4 A. Under cryoconditions (120 K), the crystals diffract to about 2.95 A.  (+info)

"Rauwolfia" is the name of a genus of plants in the dogbane family (Apocynaceae). It includes several species that have been used in traditional medicine for various purposes. The most well-known species is probably Rauwolfia serpentina, also known as Indian snakeroot or sarpagandha.

Extracts from the roots of Rauwolfia serpentina contain a number of alkaloids with pharmacological activity, including reserpine, which has been used in modern medicine to treat high blood pressure and some psychiatric disorders. However, due to its side effects, it is not commonly used today.

It's important to note that the use of Rauwolfia and its extracts should be done under medical supervision, as they can have significant effects on various body systems, including the heart, blood pressure, and nervous system.

"Rauwolfia serpentina root". DrugBank, Canadian Institutes of Health Research. 2 November 2018. Retrieved 25 November 2018. ... "Rauwolfia serpentina (drug interactions)". Drugs.com. 1 November 2018. Retrieved 25 November 2018. (Articles with short ... Finnerty, Frank A. (November 1954). "Rauwolfia serpentina root". American Journal of Medicine. 17 (5): 629-640. doi:10.1016/ ...
Everett GM, Toman JE (1959). "Mode of action of Rauwolfia alkaloids and motor activity". Biol Psychiat. 2: 75-81. Govindarajulu ... ISBN 978-1-57808-428-9. Rauwolfia Dorlands Medical Dictionary. Merck Source. 2002. "Reserpine". The Columbia Encyclopedia ( ...
Siddiqui, S. and Siddiqui, R.H. (1932). The alkaloids of Rauwolfia serpintina. Part I. Ajmaline series. Journal of the Indian ... Siddiqui, S. and Siddiqui, R.H. (1935). The alkaloids of Rauwolfia serpintina. Part II. Ajmaline series. Journal of the Indian ... Siddiqui, S. and Siddiqui, R.H. (1931). Chemical examination of the roots of Rauwolfia serpintina. Journal of the Indian ...
Bartels CC (October 1959). "Syrosingopine: a new rauwolfia preparation". The New England Journal of Medicine. 261 (16): 785-8. ...
Ajmalicine Rauwolscine Spegatrine Yohimbine PHILLIPS DD, CHADHA MS (September 1955). "The alkaloids of Rauwolfia serpentina ...
... (sometimes spelled Rauwolfia) is a genus of evergreen trees and shrubs, commonly known as devil peppers, in the ... 2012, Articles 60 and 61, particularly 60.1) SerpentinaDB Lobay D (2016). "Rauwolfia in the Treatment of Hypertension". Integr ... Also called Rauwolfia carescens; from Mexico and West Indies to Peru; naturalized in China, Indian Subcontinent, Andaman ...
Leete, Edward (1961). "Biogenesis of the Rauwolfia alkaloids alkaloids-II". Tetrahedron. 14 (1-2): 35-41. doi:10.1016/0040-4020 ...
Vakil RJ (August 1955). "Rauwolfia serpentina in the treatment of high blood pressure; a review of the literature". Circulation ...
"Chemical examination of the roots of Rauwolfia serpentina Benth". J. Indian Chem. Soc. 8: 667-80. Sandilvi AN (12 April 2003 ...
Youngken, Heber W. (1954). "Malabar Rauwolfia, Rauwolfia Micrantha Hook.F.". Journal of the American Pharmaceutical Association ... Sudha, G.G.; S. Seeni (1996). "In Vitro Propagation of Rauwolfia Micrantha, a Rare Medicinal Plant". Plant Cell, Tissue and ...
"Pentolinium and hexamethonium combined with Rauwolfia in the treatment of hypertension". The New England Journal of Medicine. ...
Morris Kupchan, S.; Obasi, Mang E. (1960). "A Note on the Occurrence of 2,6-Dimethoxybenzoquinone in Rauwolfia vomitoria". ...
Kupchan, S. Morris; Obasi, Mang E. (2006). "A note on the occurrence of 2,6-dimethoxybenzoquinone in Rauwolfia vomitoria". ...
Ruyter CM; Stockigt J (1991). "Enzymatic formation of raucaffricine, the major indole alkaloid of Rauwolfia serpentina cell- ... amino acid sequence and structure of the product of raucaffricine-O-beta-D-glucosidase from plant cell cultures of Rauwolfia ...
Pfitzner A, Polz L, Stockligt J (1986). "Properties of vinorine synthase the Rauwolfia enzyme involved in the formation of the ...
Asima Chatterjee initiated chemical investigation of alkaloids in Rauvolfia tetraphylla then known as Rauwolfia canescens. ... Indole alkaloids including serpentine, reserpine, serpentinine, and other Rauwolfia alkaloids were identified in phytochemical ...
Chatterjee's contributions to science include the following: Initiated chemical investigation of alkaloids in Rauwolfia ...
... a specific enzyme involved in the biosynthesis of the Rauwolfia alkaloid sarpagine". Tetrahedron. 40 (10): 1691-1699. doi: ...
Many types of rauwolfia were employed by jungle shamans centuries before our medical men thought of tranquilizers. Quinine and ...
The institution developed and researched several unparalleled medicines, such Rauwolfia serpentina, the medicine to recover the ...
NADP+ oxidoreductase of Rauwolfia serpentina cells: the key enzyme in biosynthesis of monoterpene alcohols". Journal of ...
Rauwolfia serpentina (containing Reserpine) are a possible treatment as they both increase MAO-A activity.[citation needed] ...
Green RS, Davolos D (May 1956). "A long-term study of the effect of crude Rauwolfia serpentina and of its alseroxylon fraction ...
Unusual species, including Rauwolfia caffra, a type of tree typically found in tropical and equatorial Africa, is found in the ...
... a specific enzyme involved in the biosynthesis of the Rauwolfia alkaloid ajmaline". Zeitschrift für Naturforschung C. 42 (4): ...
Reserpine is derived from Indian Snakeroot, Rauwolfia serpentina, known in Bihar and Uttar Pradesh as Pagal-ki-dawa (''medicine ...
Rauwolfia caffra and Rauwolfia vomitoria. In preclinical studies alstonine attenuates MK-801-induced hyperlocomotion, working ...
... catalysed by a novel cytochrome P-450-dependent enzyme from plant cell cultures of Rauwolfia serpentina". Z. Naturforsch. C: ...
... , the Harvard chemist who synthesized quinine, cortisone and rauwolfia, has now achieved one of the ...
C02AA01 Rescinnamine C02AA02 Reserpine C02AA03 Combinations of rauwolfia alkaloids C02AA04 Rauwolfia alkaloids, whole root ... whole root and diuretics C02LA09 Syrosingopine and diuretics C02LA50 Combinations of rauwolfia alkaloids and diuretics ... combinations C02AA53 Combinations of rauwolfia alkaloids, combinations C02AA57 Bietaserpine, combinations C02AB01 Methyldopa ( ... C02LA03 Deserpidine and diuretics C02LA04 Methoserpidine and diuretics C02LA07 Bietaserpine and diuretics C02LA08 Rauwolfia ...
Receive NAPRA updates of interest directly to your inbox: general NAPRA news, NDS updates and/or updates on practice resources.. ...
Meaning of rauwolfia. What does rauwolfia mean? Information and translations of rauwolfia in the most comprehensive dictionary ... Definition of rauwolfia in the Definitions.net dictionary. ... Search for rauwolfia on Amazon. *Search for rauwolfia on Google ... What does rauwolfia mean?. Definitions for rauwolfia. rɔˈwʊl fi ə, raʊ-rau·wolfi·a. This dictionary definitions page includes ... rauwolfia, rauvolfianoun. any shrub or small tree of the genus Rauwolfia having leaves in whorls and cymose flowers; yield ...
The Influence of Different Hormone Concentration and Combination on Callus Induction and Regeneration of Rauwolfia serpentina L ... Callus induction and regeneration of Rauwolfia serpentina L: (a) and (b) Induction of callus on MS medium supplemented with 0.5 ... The influence of media composition on callus induction and subsequent regeneration of Rauwolfia serpentina L. Benth has been ... Rauwolfia use and breast cancer: A case-control study. J. Natl. Cancer Inst., 76: 817-822.. PubMed ...
In India, another species is used - Rauwolfia canescens L. - grayish rauwolfia. In total, up to 150 species of the genus ... In Africa (Congo), the extraction of the root of Rauwolfia vomitoria Afz - rauwolfia emetic, whose alkaloids have a similar ... This type of rauwolfia grows in the Himalayas, in India, Burma, and also in Indonesia; cultivated in India. This is an ... The root contains more than 25 alkaloids, the sum of which is traditionally 1-2%. All rauwolfia alkaloids are derivatives of ...
Rauwolfia serpentina), also spelled ravolphia, is a medicinal plant in the milkweed family. The root of the plant is ground ... Rauwolfia serpentina root. DrugBank Accession Number. DB09363. Background. Rauwolfia (Rauwolfia serpentina), also spelled ... Rauwolfia alkaloids are indicated in the treatment of hypertension 6. Rauwolfia alkaloids have been used for relief of symptoms ... Reserpine is derived from Rauwolfia serpentina, and was commonly used as an antihypertensive agent in the 1950s 12. Rauwolfia ...
Its botanical name is Rauwolfia serpentina. It belongs to Apocynacea family.Sarpagandha being its classical sanskrit name which ...
Rauwolfia Serpentina Mother Tincture Q $3.28 - $6.21. Rated 5.00 out of 5 ... 1 review for Rauwolfia Serpentina Mother Tincture Q. *. Rated 5 out of 5 ...
4. Boericke W. Rauwolfia serpentina. Pocket Manual of Homoeopathic Materia Medica. 3rd edition, New Delhi: B. Jain Publishers; ... In Homoeopathy mother tincture are routinely prescribed for the treatment of wide variety of ailments such as Rauwolfia ...
Rauwolfia serpentina, or Indian snake root, is a well-known traditional herb for maintaining and supporting healthy blood ... Rauwolfia serpentina, or Indian snake root, i ... Vitanica, Rauwolfia Extra™ 90 Capsules. Regular price $53.76 ...
Reckeweg Rauwolfia Serpentina Mother Tincture (20ml) - 20ml \/ Mother Tincture","public_title":"20ml \/ Mother Tincture"," ... Reckeweg Rauwolfia Serpentina Mother Tincture (20ml) - 20ml \/ Mother Tincture","public_title":"20ml \/ Mother Tincture"," ...
Rauwolfia serpentina Q Schwabe Buy Online , Order Schwabe medicines online , Best Offers , Genuine Medicines , Free delivery , ... Rauwolfia serpentina Q Schwabe Buy Online , Order Schwabe medicines online , Best Offers , Genuine Medicines , Free delivery , ...
The anti-psychotic alkaloid, reserpine, also found in Rauwolfia species is removed from Rovol V during the extraction process. ... Rauwolfia vomitoria, containing the alkaloid, alstonine (also called BG-8). Research studies, many being in vitro, have shown ... An extract from the bark of the roots of the African tree, Rauwolfia vomitoria, containing the alkaloid, alstonine (also called ... The anti-psychotic alkaloid, reserpine, also found in Rauwolfia species is removed from Rovol V during the extraction process. ...
Rauwolfia alkaloids. Class Summary. These agents may improve choreic movements in patients. ...
Rauwolfia Serpentina is the scientific name for sarpagandha. This herbs roots are tuberous and have a cork that is a light ... Rauwolfia Serpentina-Sarpgandha. An erect, glabrous, evergreen perennial shrub, the sarpagandha plant typically reaches a ...
Sharma, V.N., J.D. Kohli and B. Mukerji (1954) The chemistry and pharmacology of Rauwolfia. [Publication] ...
"Rauwolfia serpentina root". DrugBank, Canadian Institutes of Health Research. 2 November 2018. Retrieved 25 November 2018. ... "Rauwolfia serpentina (drug interactions)". Drugs.com. 1 November 2018. Retrieved 25 November 2018. (Articles with short ... Finnerty, Frank A. (November 1954). "Rauwolfia serpentina root". American Journal of Medicine. 17 (5): 629-640. doi:10.1016/ ...
Return to Article Details Effect of Xanthotoxin on Potentiating Anticonvulsant Activity of Rauwolfia Serpentina in Experimental ...
Objectives Rauwolfia vomitoria is one ethno-botanicals in Nigeria used by traditional health practitioners in managing several ... Chemical composition, antioxidant, and enzyme inhibitory properties of Rauwolfia vomitoria extract. Adeniyi A. Adebayo, ... Conclusions Therefore, one of the potential reasons driving Rauwolfia vomitoria s use in folk medicine for the treatment of ... Thus, this study investigated the antioxidant property and impact of Rauwolfia vomitoria extract on erectile dysfunction- ...
Most predominant rhizobacteria found in the rhizospheres of Rauwolfia spp. of WG regions are potential PGPR which can serve as ... The present study carried out with denaturing gradient gel electrophoresis of DNA extracted from rhizosphere soils of Rauwolfia ... Structural and functional diversity of rhizobacteria associated with Rauwolfia spp. across the Western Ghat regions of ... Rauwolfia, Rauwolfia spp, Soil Microbiology, uncultured bacterium. ...
Rauwolfia serpentina (Sarpagandha), dried root please find the plants I am growing.CITES compliant. ... Rauwolfia serpentina (Sarpagandha), dried root please find the plants I grow-CITES COMPLIANT. ...
In addition, Rauwolfia Root may require (b)(4) examinations, such as (b)(4) examination of the (b)(4) to confirm its identity ... The Rauwolfia Root may have a characteristic bitter taste; however, other plants/plant roots have bitter taste as well. ... the ammonium chloride salt ingredient used in your Edema NatRelief 6 product and the Rauwolfia Root used in your BP NatRelief ...
Serpalan - Serpalan, also known asRauwolfia Alkaloid (Oral Route) * Sertaconazole (Topical Route) ...
Rauwolfia Alkaloids*Rauwolfia Alkaloids. *Alkaloids, Rauwolfia. *Rauvolfia Alkaloids. *Alkaloids, Rauvolfia. Alseroxylon* ...
Rauwolfia, Rauwolfae Radix, Rauwolfia Serpentina, Serpiria, Rauwolfiawurzel, Rauvolfia serpentina, Sarpagandha, Sarpgandha, ... Allergy to reserpine or similar medicines known as rauwolfia alkaloids: Dont take Indian snakeroot if you are allergic to ...
Pharmacological studies with deserpidine, a new alkaloid from Rauwolfia canescens. SCHNEIDER JA, PLUMMER AJ, EARL AE, BARRETT ...
tablets, described accurately as the whole root of Rauwolfia Serpentina. Comment: This is an ethical medical preparation still ... There are folders on specific drugs and chemical agents, such as Rauwolfia Serpentina, Meratran, Mitrazol, Mescaline, etc., ...
... is in a class of medications called rauwolfia alkaloids. It works by slowing the activity of the nervous system, ...
Reviewed byRauwolfia,1/4/2023. excellent trip! the Driver picked Me up from the hotel and took me to the airport, where we met ...

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