Raynaud Disease
CREST Syndrome
Scleroderma, Localized
Pruritus
Scleroderma, Systemic
Scleroderma, Diffuse
Traumatic vasospastic disease in chain-saw operators. (1/492)
Raynaud's phenomenon is commonly induced in chain-saw operators by vibration; the hand guiding the tool is the more severely affected. The condition tends to persist after use of the chain-saw is stopped but compensation is rarely sought. Among 17 cases of Raynaud's phenomenon in lumberjacks the condition was found to be related to use of the chain-saw in 14, 10 of whom had to give up their work in colder weather because the disease was so disabling. Two criteria essential to establish the condition as vibration-induced Raynaud's phenomenon are the presence of symptoms for at least 2 years and a history of at least 1 year's constant use of the chain-saw. Careful physical examination and simple tests of vascular function will provide objective evidence of permanent damage by which the patients may be classified and compensated. (+info)Different factors influencing the expression of Raynaud's phenomenon in men and women. (2/492)
OBJECTIVE: To determine whether the risk profile for Raynaud's phenomenon (RP) is different between men and women. METHODS: In this cross-sectional study of 800 women and 725 men participating in the Framingham Offspring Study, the association of age, marital status, smoking, alcohol use, diabetes, hypertension, and hypercholesterolemia with prevalent RP was examined in men and women separately, after adjusting for relevant confounders. RESULTS: The prevalence of RP was 9.6% (n = 77) in women and 5.8% (n = 42) in men. In women, marital status and alcohol use were each associated with prevalent RP (for marital status adjusted odds ratio [OR] 2.3, 95% confidence interval [95% CI] 1.4-3.9; for alcohol use OR 2.2, 95% CI 1.0-5.2), whereas these factors were not associated with RP in men (marital status OR 1.4, 95% CI 0.6-3.5; alcohol use OR 1.0, 95% CI 0.2-4.4). In men, older age (OR 2.3, 95% CI 1.0-5.2) and smoking (OR 2.6, 95% CI 1.1-6.3) were associated with prevalent RP; these factors were not associated with RP in women (older age OR 0.8, 95% CI 0.4-1.6; smoking OR 0.7, 95% CI 0.4-1.1). Diabetes, hypertension, and hypercholesterolemia were not associated with RP in either sex. CONCLUSION: The results indicate that risk factors for RP differ between men and women. Age and smoking were associated with RP in men only, while the associations of marital status and alcohol use with RP were observed in women only. These findings suggest that different mechanisms influence the expression of RP in men and women. (+info)Increased interferon-gamma (IFN-gamma) levels produced in vitro by alloactivated T lymphocytes in systemic sclerosis and Raynaud's phenomenon. (3/492)
The aim of the present study was to analyse the in vitro proliferation and cytokine production by alloantigen-stimulated peripheral blood mononuclear cells (PBMC) obtained from patients affected by systemic sclerosis (SSc) and patients with Raynaud's phenomenon (RP). In SSc patients the proliferation of PBMC stimulated in vitro with alloantigens was significantly increased compared with healthy subjects, while no differences were observed for RP patients. Lymphocytes from SSc patients also produced larger amounts of IFN-gamma compared with healthy controls. However, patients with clinically active disease had lower IFN-gamma levels than those found in clinically stable patients. Patients affected by RP showed significantly higher levels of IFN-gamma than healthy subjects. Analysis at the clonal level of the lymphocyte subsets involved in alloantigen stimulation in one patient affected by active SSc, and one subject with RP confirmed the results obtained using PBMC. In particular, in the RP patient but not in the SSc patient, we observed a population of CD4+ T cells which proliferated to alloantigens in vitro and produced high levels of IFN-gamma. We suggest that T lymphocytes producing high levels of IFN-gamma might play a protective role in RP patients and in established scleroderma. (+info)Activation of microvascular pericytes in autoimmune Raynaud's phenomenon and systemic sclerosis. (4/492)
OBJECTIVE: To determine the temporal and spatial relationship between platelet-derived growth factor beta (PDGFbeta) receptors, PDGF-AB/BB, and activated pericytes across the Raynaud's phenomenon (RP) and systemic sclerosis (SSc; scleroderma) disease spectrum. METHODS: Monoclonal antibodies against PDGFbeta receptors, PDGF-AB/BB, and high molecular weight-melanoma-associated antigen (HMW-MAA), a marker for activated pericytes, were used to immunohistochemically analyze serial sections of skin biopsy tissue from patients with RP and from scleroderma patients. To delineate cell-specific PDGFbeta receptor expression, double immunofluorescence-stained sections were analyzed using computer-aided image analysis and confocal microscopy. RESULTS: PDGFbeta receptor-expressing cells and HMW-MAA-expressing pericytes were found in biopsy samples from autoimmune RP patients and in both early fibrotic and early nonfibrotic scleroderma skin, but not in normal or primary RP or late-stage scleroderma skin. PDGF-AB/BB was expressed within the epidermis, at the epidermal/dermal junction, and by dermal macrophages. Analysis of juxtaposed serial sections revealed an increased frequency of receptor expression in microvessels from autoimmune RP and early scleroderma skin (P < 0.01). Double-labeling studies using confocal microscopy showed that, in vivo, PDGFbeta receptors were predominantly expressed by microvascular pericytes from both autoimmune RP and early scleroderma skin. CONCLUSION: PDGFbeta receptors are expressed by activated microvascular pericytes in patients with autoimmune RP and in early SSc patients, but not in those with primary RP or late-stage scleroderma. These findings suggest that features of autoimmune RP are distinct from those of primary RP, and that microvascular pericytes may be an important link between chronic microvascular damage and fibrosis. (+info)Cardiovascular responses evoked by mild cool stimuli in primary Raynaud's disease: the role of endothelin. (5/492)
In control subjects and in subjects with primary Raynaud's disease, sudden sound evokes the pattern of the alerting response, which includes cutaneous vasoconstriction and vasodilatation in forearm muscle. However, whereas this pattern of response habituates on repetition of the sound stimulus in control subjects, both cutaneous vasoconstriction and muscle dilatation persist in subjects with primary Raynaud's disease. The aim of the present study was to test whether a similar disparity exists between control subjects and those with primary Raynaud's disease for the response to mild cool stimuli, and whether the cutaneous response is accompanied by the release of endothelin-1 (ET-1). In nine subjects with primary Raynaud's disease and in nine matched controls, the left hand was placed in cool water at 16 degrees C for 2 min five times on each of three experimental sessions on days 1, 3 and 5, with blood being taken from the venous drainage of the cooled hand before and at the end of the second session. In response to the first cool stimulus in Session 1, the subjects with primary Raynaud's disease showed a decrease in digital cutaneous vascular conductance (DCVC) in both the right and left hands, as indicated by a laser Doppler recording of erythrocyte (red cell) flux divided by arterial pressure, and six of the nine subjects showed an increase in forearm vascular conductance (FVC), as indicated by forearm blood flow measured by plethysmography divided by arterial pressure. On repetition of the stimulus in Session 1, there was no change in the magnitude of the increase in FVC, but the evoked decreases in DCVC became more prolonged in both the right and the left hand. Similar responses occurred in Sessions 2 and 3; in Session 2, the ET-1 concentration increased from a baseline value of 2.15+/-0.26 fM to 2.72+/-0.37 fM after five stimuli. There was no habituation of the increase in FVC over Sessions 1, 2 and 3, judging from the mean changes in each session. Control subjects also showed a decrease in DCVC in both hands, and in eight out of nine subjects there was an increase in FVC in response to the first cool stimulus in Session 1. However, on repetition of the stimulus in Session 1, the increase in FVC habituated, while there was no prolongation of the decrease in DCVC; in addition, the ET-1 concentration did not change in Session 2 in response to the stimulus (2.07+/-0.28 compared with 2.29+/-0.30 fM). Further, the increase in FVC habituated over the three sessions, such that there was a mean decrease in FVC in Session 3. These results indicate that, in subjects with primary Raynaud's disease, there is impairment of the ability of the central nervous system to allow habituation of the cardiovascular components of the alerting response evoked by mild cooling, as with the response to sound. We propose that persistence of the cutaneous vasoconstriction of the alerting response, coupled with increased release of ET-1 secondary to vasoconstriction, prolongs such vasoconstriction and eventually leads to vasospasm. (+info)Impaired cholinergic dilator response of resistance arteries isolated from patients with Raynaud's disease. (6/492)
AIMS: We examined the effect of cooling on the response to the endothelium-dependent and -independent dilators, acetylcholine (ACh) and sodium nitroprusside (SNP), respectively, in human microvessels in vitro, and compared the responses between Raynaud's disease (RD) patients and controls, in order to assess the pathogenic role of the endothelium in RD. METHODS: Subcutaneous resistance arteries were dissected from gluteal fat biopsies taken from patients with RD (n=18) and from age-and sex-matched control subjects (n=17). Vessels were cannulated in a small vessel arteriograph, in which a pressure of 50 mmHg was maintained across the vessel wall. Cumulative concentration-response curves for ACh (10-10-10-4 m ) and SNP (10-10-10-3 m ) were generated in vessels at either 37 degrees C or 24 degrees C, with endothelium intact for ACh and removed for SNP (n=6 per group). RESULTS: Neither dilator showed significant differences in sensitivity when comparing responses between vessels from RD patients and controls, at either temperature, but the maximal relaxation to ACh was depressed in vessels from RD patients compared with controls at 37 degrees C (Emax=45+/-13 in RD vs 89+/-4 in controls; P=0.004). CONCLUSIONS: These results support the hypothesis that impaired endothelium-dependent vasodilatation is involved in the pathophysiology of RD. (+info)Probucol improves symptoms and reduces lipoprotein oxidation susceptibility in patients with Raynaud's phenomenon. (7/492)
OBJECTIVE: Reactive oxygen species have been implicated in the pathogenesis of inflammatory and vascular disease. We have undertaken a controlled trial to evaluate probucol, a synthetic antioxidant, as a potential therapy for Raynaud's phenomenon. METHODS: The study cohort included patients with systemic sclerosis (SSc; n = 20), primary Raynaud's phenomenon (n = 15) or 'autoimmune Raynaud's' (n = 5). Patients were allocated to receive either probucol (500 mg daily) or nifedipine (20 mg daily) for 12 weeks. Clinical and biochemical variables at baseline were compared with those at completion of treatment. Evaluation included assessment of Raynaud's attack frequency and severity by visual analogue scale, measurement of low-density lipoprotein (LDL) oxidation lag time, and plasma concentrations of cholesterol, triglyceride, vitamin E and vitamin C. RESULTS: There was a significant reduction of both the frequency and severity of Raynaud's attacks in the patients who received probucol, but not in the control group. LDL oxidation lag time, reflecting in vitro susceptibility to oxidation, was also increased by probucol therapy and serum cholesterol levels were significantly reduced. Similar changes were observed in both SSc- and non-SSc-associated Raynaud's cases. CONCLUSION: These data suggest that probucol may be useful for the symptomatic treatment of Raynaud's phenomenon and also reduces LDL oxidation susceptibility. Since oxidized lipoproteins may mediate vascular damage in SSc, the use of probucol could have additional disease-modifying benefits. Based upon the results of this pilot study, further evaluation of this novel form of therapy is warranted. (+info)Raynaud's syndrome in workers who use vibrating pneumatic air knives. (8/492)
PURPOSE: The use of vibrating tools has been shown to cause Raynaud's syndrome (RS) in a variety of workers, including those who use chain saws, chippers, and grinders. The diagnosis of RS in workers who use vibrating tools is difficult to document objectively. We studied a patient cohort with RS caused by the use of a vibrating pneumatic air knife (PAK) for removal of automobile windshields and determined our ability to document RS in these workers by means of digital hypothermic challenge testing (DHCT), a vascular laboratory study that evaluates digital blood pressure response to cooling. METHODS: Sixteen male autoglass workers (mean age, 36 years) with RS were examined by means of history, physical examination, arm blood pressures, digital photoplethysmography, screening serologic studies for underlying connective tissue disorder, and DHCT. RESULTS: No patient had RS before they used a PAK. The mean onset of RS (color changes, 100%; pain, 93%; parathesias, 75%) with cold exposure was 3 years (range, 1.5 to 5 years) after initial PAK use (mean estimated PAK use, 2450 hours). Fifty-six percent of workers smoked cigarettes. The findings of the physical examination, arm blood pressures, digital photoplethysmography, and serologic testing were normal in all patients. At 10 degrees C cooling with digital cuff and patient cooling blanket, a significant decrease in digital blood pressure was shown by means of DHCT in 100% of test fingers versus normothermic control fingers (mean decrease, 75%; range, 25% to 100%; normal response, less than 17%; P <.001). The mean follow-up period was 18 months (range, 1 to 47 months). No patient continued to use the PAK, but symptoms of RS were unchanged in 69% and worse in 31%. CONCLUSION: PAK use is a possible cause of vibration-induced RS. The presence of RS in workers who use the PAK was objectively confirmed by means of DHCT. Cessation of PAK use in the short term did not result in symptomatic improvement. (+info)Raynaud's disease, also known as Raynaud's phenomenon or syndrome, is a condition that affects the blood vessels, particularly in the fingers and toes. It is characterized by episodes of vasospasm (constriction) of the small digital arteries and arterioles, which can be triggered by cold temperatures or emotional stress. This results in reduced blood flow to the affected areas, causing them to become pale or white and then cyanotic (blue) due to the accumulation of deoxygenated blood. As the episode resolves, the affected areas may turn red as blood flow returns, sometimes accompanied by pain, numbness, or tingling sensations.
Raynaud's disease can be primary, meaning it occurs without an underlying medical condition, or secondary, which is associated with connective tissue disorders, autoimmune diseases, or other health issues such as carpal tunnel syndrome, vibration tool usage, or smoking. Primary Raynaud's is more common and tends to be less severe than secondary Raynaud's.
Treatment for Raynaud's disease typically involves avoiding triggers, keeping the body warm, and using medications to help dilate blood vessels and improve circulation. In some cases, lifestyle modifications and smoking cessation may also be recommended to manage symptoms and prevent progression of the condition.
CREST syndrome is a subtype of a autoimmune connective tissue disorder called scleroderma (systemic sclerosis). The name "CREST" is an acronym that stands for the following five features:
* Calcinosis: The formation of calcium deposits in the skin and underlying tissues, which can cause painful ulcers.
* Raynaud's phenomenon: A condition in which the blood vessels in the fingers and toes constrict in response to cold or stress, causing the digits to turn white or blue and become numb or painful.
* Esophageal dysmotility: Difficulty swallowing due to weakened muscles in the esophagus.
* Sclerodactyly: Thickening and tightening of the skin on the fingers.
* Telangiectasias: Dilated blood vessels near the surface of the skin, causing red spots or lines.
It's important to note that not everyone with CREST syndrome will have all five of these features, and some people may have additional symptoms not included in the acronym. Additionally, CREST syndrome is a chronic condition that can cause a range of complications, including lung fibrosis, kidney problems, and digital ulcers. Treatment typically focuses on managing specific symptoms and slowing the progression of the disease.
Localized scleroderma, also known as morphea, is a rare autoimmune disorder that affects the skin and connective tissues. It is characterized by thickening and hardening (sclerosis) of the skin in patches or bands, usually on the trunk, limbs, or face. Unlike systemic scleroderma, localized scleroderma does not affect internal organs, although it can cause significant disfigurement and disability in some cases.
There are two main types of localized scleroderma: plaque morphea and generalized morphea. Plaque morphea typically presents as oval or circular patches of thickened, hard skin that are often white or pale in the center and surrounded by a purple or darker border. Generalized morphea, on the other hand, is characterized by larger areas of sclerosis that can cover much of the body surface.
The exact cause of localized scleroderma is not fully understood, but it is thought to involve an overactive immune system response that leads to inflammation and scarring of the skin and underlying tissues. Treatment typically involves a combination of topical therapies (such as corticosteroids or calcineurin inhibitors), phototherapy, and systemic medications (such as methotrexate or mycophenolate mofetil) in more severe cases.
Pruritus is a medical term derived from Latin, in which "prurire" means "to itch." It refers to an unpleasant sensation on the skin that provokes the desire or reflex to scratch. This can be caused by various factors, such as skin conditions (e.g., dryness, eczema, psoriasis), systemic diseases (e.g., liver disease, kidney failure), nerve disorders, psychological conditions, or reactions to certain medications.
Pruritus can significantly affect a person's quality of life, leading to sleep disturbances, anxiety, and depression. Proper identification and management of the underlying cause are essential for effective treatment.
Systemic Scleroderma, also known as Systemic Sclerosis (SSc), is a rare, chronic autoimmune disease that involves the abnormal growth and accumulation of collagen in various connective tissues, blood vessels, and organs throughout the body. This excessive collagen production leads to fibrosis or scarring, which can cause thickening, hardening, and tightening of the skin and damage to internal organs such as the heart, lungs, kidneys, and gastrointestinal tract.
Systemic Scleroderma is characterized by two main features: small blood vessel abnormalities (Raynaud's phenomenon) and fibrosis. The disease can be further classified into two subsets based on the extent of skin involvement: limited cutaneous systemic sclerosis (lcSSc) and diffuse cutaneous systemic sclerosis (dcSSc).
Limited cutaneous systemic sclerosis affects the skin distally, typically involving fingers, hands, forearms, feet, lower legs, and face. It is often associated with Raynaud's phenomenon, calcinosis, telangiectasias, and pulmonary arterial hypertension.
Diffuse cutaneous systemic sclerosis involves more extensive skin thickening and fibrosis that spreads proximally to affect the trunk, upper arms, thighs, and face. It is commonly associated with internal organ involvement, such as interstitial lung disease, heart disease, and kidney problems.
The exact cause of Systemic Scleroderma remains unknown; however, it is believed that genetic, environmental, and immunological factors contribute to its development. There is currently no cure for Systemic Scleroderma, but various treatments can help manage symptoms, slow disease progression, and improve quality of life.
Diffuse scleroderma is a medical condition that falls under the systemic sclerosis category of autoimmune rheumatic diseases. It is characterized by thickening and hardening (sclerosis) of the skin and involvement of internal organs. In diffuse scleroderma, the process affects extensive areas of the skin and at least one internal organ.
The disease process involves an overproduction of collagen, a protein that makes up connective tissues in the body. This excessive collagen deposition leads to fibrosis (scarring) of the skin and various organs, including the esophagus, gastrointestinal tract, heart, lungs, and kidneys.
Diffuse scleroderma can present with a rapid progression of skin thickening within the first few years after onset. The skin involvement may extend to areas beyond the hands, feet, and face, which are commonly affected in limited scleroderma (another form of systemic sclerosis). Additionally, patients with diffuse scleroderma have a higher risk for severe internal organ complications compared to those with limited scleroderma.
Early diagnosis and appropriate management of diffuse scleroderma are crucial to prevent or slow down the progression of organ damage. Treatment typically involves a multidisciplinary approach, focusing on symptom management, immunosuppressive therapy, and addressing specific organ involvement.
Limited scleroderma, also known as limited cutaneous systemic sclerosis (lcSSc), is a subtype of scleroderma, a chronic autoimmune connective tissue disease. In this form, the fibrosis or hardening and thickening of the skin is generally limited to areas below the elbows and knees, as well as the face and neck.
The limited cutaneous form often involves the hands, causing a tightening of the skin on the fingers, known as "sclerodactyly." It can also affect the internal organs, but this is usually less severe and occurs later in the disease course compared to diffuse scleroderma.
A common characteristic of limited scleroderma is the presence of CREST syndrome, an acronym for Calcinosis, Raynaud's phenomenon, Esophageal dysmotility, Sclerodactyly, and Telangiectasia. These are specific symptoms associated with this subtype.
However, it is important to note that the manifestations of scleroderma can vary significantly from person to person, and not everyone with limited scleroderma will develop all the features of CREST syndrome.
Raynaud syndrome
Maurice Raynaud
Vascular disease
Blood vessel disorder
Prostacyclin receptor
List of eponyms (L-Z)
Biofeedback
Chilblains
Moxonidine
Irmgard Bartenieff
Cold urticaria
Cabergoline
Jonathan L. Halperin
Alpha blocker
Cyclandelate
Sympathicolysis
Henry Head
Ergotamine
Fabry disease
Alfred Washington Adson
List of drugs known for off-label use
Acrocyanosis
Non-freezing cold injury
Cold agglutinin disease
Vasa vasorum
Lev Nussimbaum
Skin temperature
Cold injury
Hapalonychia
Cold sensitive antibodies
Raynaud's Disease | Raynaud's Syndrome | MedlinePlus
Researchers Link Two Genes to Raynaud Disease
PO.09 Syncope and Raynaud's disease | Journal of Neurology, Neurosurgery & Psychiatry
Treat Raynaud's disease with the help of Ayurveda
Raynaud's Disease: Treatment and Prevention | Southern California Hospitals | Dignity Health | Dignity Health
Raynaud's Disease Treatment | Sterling, VA
Pediatric Raynaud Phenomenon: Practice Essentials, Pathophysiology, Etiology
Raynaud syndrome - Wikipedia
Raynaud's disease - medypharmasist
Raynaud's Disease (Syndrome)
Diseases and Conditions - familydoctor.org
Pruney fingers: Causes, conditions, and treatment
Raynaud's Disease | BaroMedical Canada
Raynaud's Disease - Medication Place
Raynaud's Disease - Dr. Anki Reddy's
Understanding Raynaud's Disease | Things Health
Natural Home Cures - Raynaud's Disease Treatment
Buerger's and Raynaud's Disease - Arterial Diseases
Scleroderma Treatment & Management: Approach Considerations, Pruritus, Raynaud Phenomenon
Cold Feet? It Could Be Raynaud's Disease!
Get Clued Up on Raynaud's Disease - Magnopulse
How to Cure Raynaud's Disease Naturally | LEAFtv
Raynaud's disease | Podiatry Center of New Jersey
Raynaud's phenomenon (RP) or white finger disease
Raynaud's Disease 9% Silver Socks - RaynaudsDisease.com
Hiking with Raynaud's Disease - Cable News Media
Raynaud's Disease | Syracuse Podiatry - Dr. Ryan D'Amico
Joining Care Givers - Caregivers - Living With Raynaud's Disease
Syndrome21
- Raynaud's syndrome, also known as Raynaud's disease or Raynaud's phenomenon, is a medical condition characterized by a numbing and cooling sensation of certain areas of your body-such as your fingers and toes-typically in response to cold temperatures or stress. (internal-medicine-centers.com)
- A study that assessed microcapillary status and serum concentrations of chosen cytokines, adhesive molecules, and nitric oxide in pediatric patients with primary Raynaud syndrome and secondary Raynaud syndrome found that external factor-induced vasoconstrictive effects dominated in primary Raynaud syndrome, whereas in secondary Raynaud syndrome in the course of connective tissue diseases, it was accompanied by coexistent vasodilation due to endothelial dysfunction which was partially dependent on insufficient nitric oxide release. (medscape.com)
- Raynaud syndrome, also known as Raynaud's phenomenon, is a medical condition in which the spasm of small arteries causes episodes of reduced blood flow to end arterioles. (wikipedia.org)
- Raynaud syndrome is most likely due to an exaggerated 2 adrenergic reaction that activates vasospasm, the mechanism is not defined. (thingshealth.com)
- Primary Raynaud syndrome is more common than secondary, it happens without symptoms or signs of other illnesses. (thingshealth.com)
- Raynaud syndrome might accompany migraine head aches, variant angina, and pulmonary high blood pressure, indicating these problems share a typical vasospastic mechanics. (thingshealth.com)
- Raynaud syndrome does not happen proximal to the metacarpophalangeal joints, it most often affects the middle 3 fingers and seldom affects the thumb. (thingshealth.com)
- Vasospasm might last minutes to hours, but is seldom serious enough to cause tissue loss in primary Raynaud syndrome. (thingshealth.com)
- Raynaud syndrome secondary to a connective tissue disorder might progress to painful digital gangrene, Raynaud syndrome second to systemic sclerosis tends to cause very painful, infected ulcers on the fingertips. (thingshealth.com)
- Acrocyanosis also causes colour change of the digits in reaction to cold, but differs from Raynaud syndrome in that it's persistent, not easily reversed, and doesn't cause trophic changes, ulcers, or pain. (thingshealth.com)
- While the precise cause of Raynaud's syndrome is not known, it has been linked to a variety of health conditions and diseases. (yournextstep.net)
- Raynaud's disease, syndrome, or phenomenon is an abnormal condition where arteries in the extremities such as the toes and fingers suddenly constrict. (cablenewsmedia.com)
- What is Raynaud syndrome? (msdmanuals.com)
- Raynaud syndrome is a problem with blood flow in your fingers and rarely your toes. (msdmanuals.com)
- What causes Raynaud syndrome? (msdmanuals.com)
- Most of the time there's no clear cause of Raynaud syndrome. (msdmanuals.com)
- What are the symptoms of Raynaud syndrome? (msdmanuals.com)
- How can doctors tell if I have Raynaud syndrome? (msdmanuals.com)
- Doctors can usually tell you have Raynaud syndrome by examining you and asking you about your symptoms. (msdmanuals.com)
- How do doctors treat Raynaud syndrome? (msdmanuals.com)
- Doctors will treat any health problems causing your Raynaud syndrome. (msdmanuals.com)
Phenomenon17
- Researchers have identified two genes that may contribute to Raynaud phenomenon, a condition where blood vessels in the extremities constrict and limit blood flow. (medscape.com)
- Raynaud phenomenon (RP) was first described by Maurice Raynaud in 1862 and refers to a transient vasospasm of peripheral arteries and arterioles that classically results in triphasic color changes in the affected region. (medscape.com)
- Raynaud phenomenon showing demarcation of color difference. (medscape.com)
- Raynaud phenomenon can be primary (idiopathic), meaning no associated diseases are present (about 80-90% of cases), or secondary, meaning that another condition is believed to be the cause of the Raynaud phenomenon. (medscape.com)
- [ 16 ] Primary Raynaud phenomenon rarely leads to significant problems and does not usually need to be treated with medications. (medscape.com)
- In contrast, secondary Raynaud phenomenon, especially when associated with scleroderma-related diseases, often causes irreversible digital ischemia, resulting in the development of digital ulcers or even digital amputation. (medscape.com)
- Raynaud phenomenon can be thought of as an exaggerated normal response to cold and emotional stress. (medscape.com)
- Primary Raynaud phenomenon rarely affects the nutritive flow, whereas secondary Raynaud phenomenon can cause digital artery vasospasm severe enough to block the nutritive flow, leading to tissue hypoxia and ischemia. (medscape.com)
- patients with secondary Raynaud phenomenon have a greater defect than patients with primary Raynaud phenomenon. (medscape.com)
- Raynaud phenomenon patients also show impairments in neural regulation of vascular tone. (medscape.com)
- Both primary Raynaud phenomenon and secondary Raynaud phenomenon patients have decreased levels of calcitonin gene-related peptide (CGRP), a potent vasodilator released from sensory afferents. (medscape.com)
- Raynaud's phenomenon is the initial symptom that presents for 70% of patients with scleroderma, a skin and joint disease. (wikipedia.org)
- Distinguishing Raynaud's disease (primary Raynaud's) from Raynaud's phenomenon (secondary Raynaud's) is important. (wikipedia.org)
- Raynaud's disease, also known as 'Raynaud's phenomenon', is a very common condition that affects approximately 20% of the adult population. (magnopulse.com)
- Primary Raynaud's phenomenon is also called Raynaud's disease. (giachinoplasticsurgery.com)
- In 11 patients, Raynaud's phenomenon was associated with the autoimmune disease systemic sclerosis (scleroderma) or other connective tissue disorder. (plasticsurgery.org)
- The other two patients had primary Raynaud's phenomenon, with no underlying disease. (plasticsurgery.org)
Maurice Raynaud1
- The condition is named after the physician Auguste Gabriel Maurice Raynaud, who first described it in his doctoral thesis in 1862. (wikipedia.org)
Symptoms20
- If you are experiencing symptoms of Raynaud's disease, treatment is available to prevent complications and provide you relief. (internal-medicine-centers.com)
- Primary Raynaud's disease , also known simply as Raynaud's disease, refers to when the symptoms associated with the condition occur on their own, separate from any underlying conditions. (internal-medicine-centers.com)
- Raynaud's disease, or primary Raynaud's, is diagnosed if the symptoms are idiopathic, that is, if they occur by themselves and not in association with other diseases. (wikipedia.org)
- citation needed] Patients with secondary Raynaud's can also have symptoms related to their underlying diseases. (wikipedia.org)
- However, the majority of sufferers have "Primary Raynaud's" or "Raynaud's Disease" - where the cause of these symptoms remains a mystery. (inreachphysio.ca)
- Find doctor-approved information about symptoms, causes, diagnosis, treatment and prevention of common diseases and conditions. (familydoctor.org)
- The key symptoms of Raynaud's disease are fingers turning white or blue in the cold, numbness, and tingling. (medicalnewstoday.com)
- Cold hands are one of the symptoms in Raynaud's disease. (drankireddy.com)
- In the remaining 20% of individuals with Raynaud symptoms, a causative inherent disease will be evident at first presentation or diagnosed later. (thingshealth.com)
- 50 percent of the sufferers with an underlying liver condition show no symptoms of the disease. (thingshealth.com)
- If you are having symptoms of Raynaud's disease, our podiatrists can help control or prevent flare-ups in the following ways. (yournextstep.net)
- We find that some patients find benefit from taking prescription drugs to help control Raynaud's symptoms and treat their underlying illnesses or diseases. (yournextstep.net)
- Use meditate tapes, listen to relaxing music or distract yourself with a hobby to keep stress levels from triggering the symptoms of Raynaud's disease. (leaf.tv)
- Take 80 mg of ginkgo extract twice a day to diminish the symptoms associated with Raynaud's disease. (leaf.tv)
- There are medications available to treat the disease if symptoms worsen. (syracusepodiatry.org)
- For people with Raynaud's disease, keeping warm is essential to manage symptoms, and wearing nipple covers can be helpful. (nipppi.net)
- Continue reading to learn more about the different types of connective tissue diseases and their symptoms. (medicalnewstoday.com)
- If a person has symptoms of more than one of these conditions, they may have mixed connective tissue disease. (medicalnewstoday.com)
- Over time, these small arteries become thicken slightly, further limiting blood flow and symptoms of Raynaud's disease manifested. (ayurvedapc.blog)
- He did not know that the symptoms could be a precursor or accompaniment to future cardiovascular, autoimmune, and other diseases like we do today. (zenandvitality.com)
Gangrene1
- Severe disease may in rare cases lead to complications, specifically skin sores or gangrene. (wikipedia.org)
Systemic2
- To date, the US Food and Drug Administration (FDA) has approved nintedanib and as well as tocilizumab for refractory, progressive intersitial lung disease due to systemic sclerosis. (medscape.com)
- In patients with systemic sclerosis-related interstitial lung disease, a clinically meaningful decline of 10% or more in lung function was seen in 24.5% of placebo recipients, compared with 8.6% of tocilizumab recipients. (medscape.com)
Disorder4
- Raynaud's disease is a rare disorder of the blood vessels, usually in the fingers and toes. (medlineplus.gov)
- Raynaud's disease is a disorder associated with the blood vessels and the affected regions are usually the toes and the fingers. (unlike.net)
- Raynaud's disease is a disorder that makes the blood vessels constrict, thereby cutting off blood flow to the patient's extremities. (yournextstep.net)
- Raynaud's Disease is a disorder that affects the hands and feet. (footdoctoreastbay.com)
Buerger's9
- Buerger's disease and Raynaud's disease are two vascular disorders. (differencebetween.com)
- Buerger's disease is an inflammatory obliterative condition whereas Raynaud's disease is a vascular ailment that is characterized by the appearance of digital pallor, cyanosis, and rubor. (differencebetween.com)
- Raynaud's disease is commonly seen among young females whereas Buerger's disease predominantly occurs in middle age smoking males. (differencebetween.com)
- This is the key difference between Raynaud's disease and Buerger's disease. (differencebetween.com)
- Buerger's disease (thromboangiitis obliterans) is typically seen among male smokers of 20 to 30 years of age. (differencebetween.com)
- Superficial thrombophlebitis is the end result of Buerger's disease affecting the veins. (differencebetween.com)
- Buerger's disease is an inflammatory obliterative condition. (differencebetween.com)
- There are no such signs observed in Buerger's disease. (differencebetween.com)
- The key difference between Raynaud's disease and Buerger's disease is that Raynaud's disease is commonly seen among young females whereas Buerger's disease predominantly occurs in middle age smoking males. (differencebetween.com)
Secondary Raynaud's3
- There is also secondary Raynaud's, which is caused by injuries, other diseases, or certain medicines. (medlineplus.gov)
- Secondary Raynaud's is caused by other underlying diseases such as autoimmune disorders, medications, or injuries. (cablenewsmedia.com)
- Unlike primary disease, secondary Raynaud's disease is associated with the permanent obstruction of the digital arteries, ulceration, necrosis , and pain. (differencebetween.com)
Ayurvedic treatment for raynaud's disease1
- The reason why one should opt for ayurvedic treatment for raynaud's disease is that it is 100% safe and effective. (unlike.net)
Affects4
- Raynaud's disease is an uncomfortable condition that affects the feet, hands, nose and ears, and causes super-sensitivity to changes in temperature, particularly cold temperatures. (leaf.tv)
- Raynaud's disease is a condition that affects the blood flow to certain parts of the body, usually the fingers and toes. (nipppi.net)
- Neuropathy often affects the feet and legs, but it can also occur in the hands and arms, according to the National Institute of Diabetes and Digestive and Kidney Diseases . (livestrong.com)
- Lupus is a non-infectious and chronic autoimmune disease that affects different parts of the body. (cdc.gov)
Constrict1
- Some of them can cause your blood vessels to constrict and trigger a Raynaud's disease attack. (dignityhealth.org)
Cure for raynaud's disease2
- There is definitely an ayurvedic cure for raynaud's disease. (unlike.net)
- There is no cure for Raynaud's disease, but a person with the condition can take steps to reduce stress levels and ensure they do not get too cold. (medicalnewstoday.com)
Interventions2
- The first-line treatment for primary Raynaud is behavioral interventions, like maintaining body and extremity warmth and avoiding certain vasoconstricting drugs, said Kimberly Lakin, MD , a rheumatologist at the Hospital for Special Surgery in New York City, who not involved in the research. (medscape.com)
- For those with milder Raynaud's Disease, interventions center around evading triggers and naturally ameliorating blood circulation. (ehypnosisdownloads.com)
Fingers4
- Raynaud's disease can make your fingers or toes throb and pale when they are cold or under stress. (dignityhealth.org)
- Explore Raynaud's disease, and how it impacts our toes and fingers. (podiatrycenternj.com)
- Are you grappling with Raynaud's Disease, experiencing episodes where your fingers or toes turn icy cold, even to the point of pain? (ehypnosisdownloads.com)
- Raynaud's Disease leads to intense cold sensations in fingers, toes, and other extremities, primarily due to cold conditions or emotional upheavals. (ehypnosisdownloads.com)
Vascular3
- This is an uncommon form, and it is always secondary to local or regional vascular disease. (wikipedia.org)
- It commonly progresses within several years to affect other limbs as the vascular disease progresses. (wikipedia.org)
- Disease-modifying treatment aims at inhibiting tissue fibrosis and vascular and immune system alterations, which are the three crucial components of disease pathogenesis. (medscape.com)
Commonly3
- The disease more commonly occurs in women, and in people who live in colder climates. (internal-medicine-centers.com)
- Crohn's Disease is an Inflammatory Bowel Disease commonly referred to as IBD. (thingshealth.com)
- Raynaud's disease is most commonly triggered by low temperatures or stressful situations. (magnopulse.com)
Toes1
- The Raynaud's Disease 9% Silver Socks are ideal for those suffering from Raynaud's Disease as they are proven to help keep your feet and toes warmer. (raynaudsdisease.com)
Severe4
- Though Raynaud can be an annoyance for some, it can also cause severe pain and require medication. (medscape.com)
- Secondary Raynaud is a rarer type of the condition that occurs along with autoimmune disorders, such as scleroderma, and is generally more severe. (medscape.com)
- Social determinants of health , along with hormonal and genetic factors, can lead to more severe disease in racial and ethnic minority groups. (cdc.gov)
- Bubonic plague, a severe infectious disease which, in the absence of appropriate antimicrobial drug therapy, can evolve to a rapidly fatal septicemia or pneumonia, can develop. (cdc.gov)
Lupus6
- CDC and partners are working to make lupus visible by raising awareness about this disease. (cdc.gov)
- Lupus is a lifelong disease that can cause pain, redness, and swelling in any part of the body. (cdc.gov)
- People with a family history of lupus or other autoimmune diseases. (cdc.gov)
- Lupus is a chronic disease with no cure. (cdc.gov)
- A rheumatologist is a doctor who specializes in the diseases of joints, muscles, and systematic autoimmune diseases such as lupus. (cdc.gov)
- Women who are Black or African American are four times more likely to have end stage kidney disease caused by lupus. (cdc.gov)
Autoimmune disorders1
- a test that is positive for the presence of these antibodies could indicate a stimulated immune system, a common sign of those with connective tissue diseases or other autoimmune disorders. (internal-medicine-centers.com)
Arthritis1
- As it's a head-to-toe cover for most chairs, the cover warms the whole of your body to provide relief from Raynaud's disease, arthritis, and aches and pains. (raynaudsdisease.com)
Occurs1
- When the Raynaud's Disease occurs of its own or there is no other cause for this, then it is termed as Primary Raynaud's Disease . (herbpathy.com)
Genetics1
- Inherited connective tissue diseases occur as a result of genetics. (medicalnewstoday.com)
Illnesses1
- Our mission at Ben's Friends is to ensure that patients living with rare diseases or chronic illnesses, as well as their caregivers, family, and friends, have a safe and supportive place to connect with others like them. (livingwithraynaudsdisease.org)
Extremities3
- Raynaud's disease is when the small arteries that circulate blood in the extremities, such as the hands and feet, become narrow due to vapospasms. (syracusepodiatry.org)
- Raynaud's Disease is a disease of the Extremities. (herbpathy.com)
- The discoloration of Extremities due to extreme cold and stress is Raynaud's Disease. (herbpathy.com)
Coronary heart d1
- 5) Behavior Questionnaire elicited data on behavior which may be associated with coronary heart disease for examined persons ages 25-74. (cdc.gov)
Medscape1
- Cite this: Tobacco Use and Skin Disease - Medscape - Jun 01, 2001. (medscape.com)
Genetic2
- It's long been suspected that Raynaud had some genetic component, because half of patients with Raynaud have another family member with the same condition, said Laura Hummers, MD , who co-directs the John Hopkins Scleroderma Center in Baltimore. (medscape.com)
- Sometimes, a gene may change during or after pregnancy, resulting in a child having a sporadic genetic connective tissue disease when no family history of the condition exists. (medicalnewstoday.com)
Condition7
- Raynaud is a relatively common condition, affecting 2%-5% of the general population. (medscape.com)
- Raynaud's disease is a rare condition that narrows your blood vessels. (familydoctor.org)
- Raynaud's disease is a condition that causes issues with blood flow. (podiatrycenternj.com)
- is a welcoming, supportive community intended for close friends and family members who are caring for someone with a rare disease or condition. (livingwithraynaudsdisease.org)
- The Complete Raynaud's Disease Body Protection Bundle is a fantastic way of staying warm this winter to reduce the likelihood that you'll suffer from the condition. (raynaudsdisease.com)
- Primary Raynaud's disease is not considered as a serious condition and the chance of it causing ulcerations and infractions is very low. (differencebetween.com)
- Raynaud's disease is a condition in which numbness and feeling cold in some areas of the body in certain circumstances. (ayurvedapc.blog)
People8
- Many people have cold feet during the winter months , but patients suffering from Raynaud's disease can experience numbness or cold in their feet any time of the year. (yournextstep.net)
- In this post, we will discuss nipple covers for people with Raynaud's disease and how they can be beneficial. (nipppi.net)
- Nipple covers for people with Raynaud's disease can be made of materials that provide insulation and warmth, such as fleece or wool. (nipppi.net)
- One of the benefits of nipple covers for people with Raynaud's disease is that they can help keep the nipples warm, which can reduce the risk of them turning white or blue. (nipppi.net)
- Another benefit of nipple covers for people with Raynaud's disease is that they can provide protection against friction and irritation. (nipppi.net)
- They can also help prevent chafing or blisters, which can be a problem for people with Raynaud's disease. (nipppi.net)
- In conclusion, nipple covers can be beneficial for people with Raynaud's disease. (nipppi.net)
- People who've experienced sustained pressure on - or trauma to - a nerve can be at increased risk for paresthesia, according to the National Institute of Neurological Disorders and Stroke , as can people with specific diseases. (livestrong.com)
Primary5
- They identified more than 5100 individuals with Raynaud, of which, 68% had primary Raynaud. (medscape.com)
- The genes identified are associated with primary Raynaud. (medscape.com)
- Sometimes described as an "allergy to coldness," primary Raynaud's disease often develops in young women in their teens and early adulthood. (internal-medicine-centers.com)
- Analysis is clinical, testing focuses on differentiating primary from secondary disease. (thingshealth.com)
- The primary criterion for assessing data quality and validity was the demonstration of a causal relationship between tobacco use and skin/mucous membrane disease. (medscape.com)
Pulmonary Disease1
- Although the association between tobacco and cardiovascular disease, pulmonary disease, and cancer is well known to health care professionals, the many skin diseases caused by tobacco use may be less recognizable. (medscape.com)
Cold8
- One of the prime reasons for having this disease is continuous access to cold temperature or stress. (unlike.net)
- Raynaud's disease is an extreme sensitivity to cold. (medicalnewstoday.com)
- Raynaud's disease is often worsened by cold temperatures, it's good practice to keep those affected areas warm. (magnopulse.com)
- Raynaud's Disease shouldn't prevent you from hiking or backpacking even in cold weather. (cablenewsmedia.com)
- Raynaud's disease usually does not involve treatment, aside from exercising to maintain good circulation and keeping warm with thick gloves and socks in cold weather. (syracusepodiatry.org)
- Cold environments are difficult to deal with, but they're particularly hazardous for those who suffer from Raynaud's disease. (raynaudsdisease.com)
- When you suffer from Raynaud's disease, you might feel the cold more than others. (raynaudsdisease.com)
- If you have heart disease or high blood pressure, follow your doctor's advice about shoveling snow or performing other hard work in the cold. (cdc.gov)
Patients5
- Syncope and Raynaud's disease improved in parallel, in all patients, after treatment with a calcium channel blocker (Nifedipine). (bmj.com)
- While Raynaud's disease may sound rare to you, our doctors and staff at Dignity Health Southern California have helped many patients with Raynaud's disease reduce their pain and get back to enjoying quality lives. (dignityhealth.org)
- CaregiverSupport.org is an online support group for patients, friends and families affected by a rare disease. (livingwithraynaudsdisease.org)
- The patients on any one of Ben's Friends communities will have specific things in common because of their disease. (livingwithraynaudsdisease.org)
- Everyone - rare disease patients and caregivers - wins. (livingwithraynaudsdisease.org)
Disorders1
- This review of the literature shows that a number of disorders and diseases of the skin and mucous membranes are related to tobacco use. (medscape.com)
Immune System1
- In autoimmune connective tissue diseases, the immune system attacks healthy connective tissue, causing inflammation and damage. (medicalnewstoday.com)
Common1
- Meanwhile, their caregivers may have things in common with other caregivers, independent of disease. (livingwithraynaudsdisease.org)