A term infant with severe hypereosinophilia secondary to CMV infection and the STAT1 gene mutation: a case report : List of...

STAT1 Mutations in Chronic Mucocutaneous Candidiasis Diagnosed in an Adult.

The complementary roles of STAT3 and STAT1 in cancer biology: insights into tumor pathogenesis and therapeutic strategies.

STAT1 overexpression triggers aplastic anemia: a pilot study unravelling novel pathogenetic insights in bone marrow failure.

Novel heterozygous TREX1 mutation in a juvenile systemic lupus erythematosus patient with severe cutaneous involvement treated...

The role of Janus kinase signaling in the pathology of atopic dermatitis.

The role of the interferon/JAK-STAT axis in driving islet HLA-I hyperexpression in type 1 diabetes.

JAKs and STATs from a Clinical Perspective: Loss-of-Function Mutations, Gain-of-Function Mutations, and Their Multidimensional...

The role of JAK/STAT signaling pathway in cerebral ischemia-reperfusion injury and the therapeutic effect of traditional...

Cyclin-dependent kinase 8

T helper cell

GBP2

IRF2

IRF8

Perlecan

Interferon gamma

Interleukin 27

Interleukin 24

Paracrine signaling

IFNA2

PIAS1

MAPK14

N-myc-interactor

Interleukin 26

Toll-like receptor 7

List of MeSH codes (D12.776.476)

Interferon

Fibroblast growth factor receptor 4

Eastern equine encephalitis

STAT1

Immunologic constant of rejection

Transcription factor

Uncharacterized protein C15orf32

Endogenous retrovirus

NBPF1

STAT4

Rhabdoviridae

Interleukin-28 receptor

Thanatophoric dysplasia

Histone deacetylase 2

STAT2

Colony stimulating factor 1 receptor

Heat shock protein 90kDa alpha (cytosolic), member A1

IL2RA

Macrophage polarization

ChIP sequencing

Neurogenins

JAK-STAT signaling pathway

Interleukin 35

Thymic stromal lymphopoietin

Ebola viral protein 24

Oncostatin M

Tofacitinib

STAT34

• - SOCS proteins are inducible inhibitors that negatively regulate STAT3/STAT1 signaling pathways induced by cytokines, IL-6 or IFNs. - Here we aimed to explore the effect of acute alcohol on induction of SOCS1/SOCS3 and regulation of STAT3/STAT1 pathways induced by IL-6 or IFNs in human monocytes. - Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. - Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. - Mass spectrometry analysis of DNMT3L binding partners identified 1144 proteins, including the STAT1 and STAT3 transcription factors, where it increased their phosphorylation and translocation to the nucleus. - By signaling through this receptor complex, IL-26 induces rapid phosphorylation of the transcription factors STAT1 and STAT3, which enhance IL-10 and IL-8 secretion and as expression of the CD54 molecule on the surface of epithelial cells. ( ncbi.nlm.nih.gov | olink.com | epigenie.com | genemedi.net )

Phosphorylation5

• - Western blotting was used to assess signal transducer and activator of transcription (STAT) phosphorylation. - 5 , 6 Iron availability also impacts macrophage expression of proinflammatory cytokines and phosphorylation of Janus kinase (JAK)/signal transducer and activator of transcription (STAT) proteins involved in cytokine receptor signaling and the potentiation of inflammatory responses, 7 - 9 as well as the synthesis of toxic reactive oxygen species (ROS) and reactive nitrogen species involved in macrophage killing of phagocytosed microorganisms. - Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. - Type I IFNs bind to their receptor, IFNAR, leading to the phosphorylation of transcription factors (TFs) STAT1 and STAT2, which bind IFN regulatory factor (IRF) 9 to form a complex called the ISG factor 3 (ISGF3). - To better understand how PADI4 may facilitate gene transactivation, we then show that PADI4 interacts with Elk-1 at the c-Fos promoter and that, following Epidermal Growth Factor (EGF) stimulation, PADI4 catalytic activity facilitates Elk-1 phosphorylation, histone H4 acetylation, and c-Fos transcriptional activation. - STAT transcription factors are recruited to the cytoplasmic region of CELL SURFACE RECEPTORS and are activated via PHOSPHORYLATION . ( apb.tbzmed.ac.ir | peptimmune.com | adipogen.com | prolekarniky.cz | meshb.nlm.nih.gov )

Proteins4

• - Binding to dsRNA by these proteins may result in initiation of helicase activity, concomitant with a conformational change that leads to recruiting additional cellular factors, including the recently identified IPS-1/MAVS protein ( 5 , 6 ). - 2 , 3 Iron is an indispensable co-factor in many important biological processes such as erythropoiesis, DNA synthesis and repair, and mitochondrial function, all of which involve iron-containing and iron-sequestering proteins. - Recent studies have examined the therapeutic potential of the sodium-glucose cotransporter 2 (SGLT2) inhibitors in neurodevelopmental diseases, based on their proved anti-inflammatory effects, such as downregulating the expression of several proteins, including the transforming growth factor beta (TGF-β), interleukin-6 (IL-6), C-reactive protein (CRP), nuclear factor κB (NF-κB), tumor necrosis factor alpha (TNF-α), and the monocyte chemoattractant protein (MCP-1). - STAT2 often forms a complex with STAT1 and other proteins such as IRF9 to initiate the transcription of interferon-stimulated genes (ISGs). - In these pathways it interacts with proteins like JAK1 TYK2 and STAT1 playing a part in transmitting signals from the cell surface to the nucleus. ( wwwnc.cdc.gov | apb.tbzmed.ac.ir | epiphanyasd.com | abcam.com )

Activator of transcription5

• - We previously reported that alcohol activates janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling leading to IL-10 induction. - Treatment of melanoma cells with IFN-α or IFN-β triggers IFNAR-mediated Janus kinase-signal transducer and activator of transcription (JAK/STAT) signaling, increases chromatin accessibility and resultant STAT1/2 and IFN regulatory factor 9 (IRF9) binding within a PD-1 gene enhancer, and leads to PD-1 induction. - A signal transducer and activator of transcription that mediates cellular responses to INTERFERONS . - These transcription factors co-localize at targets like signal transducer and activator of transcription 1 (STAT1). - The Signal Transducer and Activator of Transcription 2 commonly known as STAT2 is a protein with a molecular mass of approximately 97 kDa. ( ncbi.nlm.nih.gov | pubmed.ncbi.nlm.nih.gov | meshb-prev.nlm.nih.gov | azolifesciences.com | abcam.com )

Pathways4

• - The top 20 biological processes obtained were related to pathways such as positive regulation of ribonucleic acid polymerase II promoter transcription, positive regulation of transcription, negative regulation of the apoptotic process, inflammatory response, lipopolysaccharide-mediated signaling pathway and cellular response to hypoxia. - The top 20 pathways obtained involved cancer pathways, tumor necrosis factor signaling pathway, T cell receptor signaling pathway, nucleotide-binding oligomerization domain-like receptor signaling pathway, hypoxia-inducible factor 1 signaling pathway, toll-like receptor signaling pathway, etc. - A novel gene discovery protocol, integrating three literature-derived and data-driven modeling strategies, was employed to identify causal pathways and direct causal factors based on differentially expressed transcripts associated with exercise intensity and amount. - Two key signaling pathways mediating aerobic exercise-induced Si improvements were identified: one centered on estrogen signaling and the other on phorbol ester (PKC) signaling, both converging on the epidermal growth factor receptor (EGFR) and other relevant targets. - Here we report that Blimp-1 regulates expression of viral defense, IFN signaling and MHC class I pathways, and directly targets the transcriptional activator Stat1. - The interaction of cGAS-STING with other pathways, such as the nuclear factor-kappa B (NF-κB), Jun N-terminal kinase (JNK), AMP-activated protein kinase (AMPK), mammalian target of rapamycin (mTOR), autophagy, pyroptosis and insulin signalling pathways, is considered an important mechanism by which cGAS-STING regulates inflammation and metabolism. ( ijpsonline.com | scholars.duke.edu | stemcells.ox.ac.uk | ijbs.com )

STAT21

• - All IFNαs and IFNβ bind to the same receptor and as a result, the cytoplasmic kinases JAK1 and TYK2 become activated and phosphorylate the STAT1 and STAT2 molecules. ( wwwnc.cdc.gov )

JAK11

• - Treatment with ruxolitinib, a Janus kinase 1/2 (JAK1/JAK2) inhibitor, which reduces the activated phosphorylated form of STAT1, reduced differentiation-associated markers such as the cluster of differentiation 11b (CD11b). ( azolifesciences.com )

Regulatory factor1

• - The treatment promotes cell differentiation and maturation by enhancing the expression of type I interferon (IFN) genes that primarily activate two transcription factors, IFN regulatory factor 7 (IRF7) and β-catenin. ( azolifesciences.com )

Protein4

• - Stat1 interacts with P53 TUMOR SUPPRESSOR PROTEIN and regulates expression of GENES involved in growth control and APOPTOSIS . - The dilution factor for this assay is noted below and should be taken into account when estimating the appropriate addressable biological concentration of the protein based on the in vitro validation data. - The FGFR3 gene provides instructions for making a protein called fibroblast growth factor receptor 3. - This protein is part of a family of four fibroblast growth factor receptors that share similar structures and functions. - This allows the protein to interact with specific growth factors outside the cell and receive signals that control growth and development. - When these growth factors attach to the FGFR3 protein, the protein is turned on (activated). - This variant creates a protein that turns on without the help of a growth factor, which means that the FGFR3 protein is constantly active. - An important target of MAPK/ERK activity is Elk-1 (Ets-like protein-1), a member of the ternary complex factors family of ETS domain transcription factors. ( meshb-prev.nlm.nih.gov | olink.com | medlineplus.gov | prolekarniky.cz )

Induces2

• - The elevated expression was observed more in patients with COVID-19 than uninfected donors, suggesting cell infection induces C3 gene transcription. - Equally, experiments in diabetic mouse models have demonstrated that inhibition of TWEAK significantly reduces the progression of atherosclerotic lesions and induces a more stable plaque phenotype, partly via suppression of STAT1 signalling. ( news-medical.net | nature.com )