Neuroprotective properties of gallic acid from Sanguisorbae radix on amyloid beta protein (25--35)-induced toxicity in cultured rat cortical neurons. (1/6)
Our previous studies reported that methanol extract of Sanguisorbae radix from Sanguisorba officinalis L. (Rosaceae) prevented neuronal cell damage induced by Abeta (25-35) in vitro. The present study was carried out to investigate the effect of gallic acid isolated from Sanguisorbae radix on Abeta (25-35)-induced neurotoxicity using cultured rat cortical neurons. Gallic acid (0.1, 1 microM) showed a concentration-dependent inhibition on Abeta (25-35) (10 microM)-induced apoptotic neuronal death, as assessed by a 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyl-tetrazolium bromide (MTT) assay and Hoechst 33,342 staining. Pretreatment of gallic acid inhibited 10 microM Abeta (25-35)-induced elevation of cytosolic Ca(2+) concentration ([Ca(2+)](c)) and generation of reactive oxygen species (ROS), which were measured by fluorescent dyes. Gallic acid also inhibited glutamate release into medium induced by 10 microM Abeta (25-35), which was measured by HPLC. These results suggest that gallic acid prevents Abeta (25-35)-induced apoptotic neuronal death by interfering with the increase of [Ca(2+)](c), and then by inhibiting glutamate release and generation of ROS, and that these effects of gallic acid may be partly associated with the neuroprotective effect of Sanguisorbae radix. (+info)Neuroprotective effect of Sanguisorbae radix against oxidative stress-induced brain damage: in vitro and in vivo. (2/6)
Sanguisorbae radix (SR), the root of Sanguisorba officinalis L. (Rosaceae), has been traditionally used for its anti-inflammatory, anti-infectious and analgesic activities in Korea. Previous work has shown that SR prevents neuronal cell damage induced by Abeta (25--35) in cultured rat cortical neurons. The present study was carried out to further investigate the neuroprotective effect of SR on oxidative stress-induced toxicity in primary culture of rat cortical neurons, and on ischemia-induced brain damage in rats. SR, over a concentration range of 10--50 microg/ml, inhibited H2O2 (100 microM)-induced neuronal death, which was significantly inhibited by MK-801 (5 microM), an N-methyl-D-aspartate (NMDA) receptor antagonist, and verapamil (20 microM), an L-type Ca2+ channel blocker. Pretreatment of SR (10-50 microg/ml), MK-801 (5 microM), and verapamil (20 microM) inhibited H2O2-induced elevation of intracellular Ca2+ concentration ([Ca2+]i) measured by a fluorescent dye, Fluo-4 AM. SR (10-50 microg/ml) inhibited H2O2-induced glutamate release into medium measured by HPLC, and generation of reactive oxygen species (ROS) measured by 2',7'-dichlorodihydrofluorescein diacetate (H2DCFDA). In vivo, SR prevented cerebral ischemic injury induced by 2-h middle cerebral artery occlusion (MCAO) and 24-h reperfusion. The ischemic infarct and edema were significantly reduced in rats that received SR (10, 30 mg/kg, orally), with a corresponding improvement in neurological function. Catechin isolated from SR inhibited H2O2-induced neuronal death in cultures. Taken together, these results suggest that SR inhibits H2O2-induced neuronal death by interfering with the increase of [Ca2+]i, and inhibiting glutamate release and generation of ROS, and that the neuroprotective effect of SR against focal cerebral ischemic injury is due to its anti-oxidative effects. Thus SR might have therapeutic roles in neurodegenerative diseases such as stroke. (+info)Triterpenoids from the roots of Sanguisorba tenuifolia var. Alba. (3/6)
(+info)Sanguisorba minor extract suppresses plasmin-mediated mechanisms of cancer cell migration. (4/6)
(+info)Terpene glycosides from the roots of Sanguisorba officinalis L. and their hemostatic activities. (5/6)
(+info)Isolation and identification of the phenolic compounds from the roots of Sanguisorba officinalis L. and their antioxidant activities. (6/6)
(+info)"Sanguisorba" is a botanical term that refers to a genus of flowering plants in the Rosaceae family, also known as "great burnet" or "salad burnet." The name "Sanguisorba" comes from the Latin word "sanguis," meaning blood, and "sorbere," meaning to absorb, referring to its historical use in medicine for stopping bleeding.
While "Sanguisorba" itself is not a medical term, some of its species have been used in traditional medicine for various purposes, such as treating wounds, diarrhea, and menstrual disorders. However, it's important to note that the scientific evidence supporting these uses is limited, and further research is needed before any definitive medical claims can be made.
If you are interested in using "Sanguisorba" or any of its species for medicinal purposes, it's recommended that you consult with a healthcare professional first to ensure safety and effectiveness.
A plant extract is a preparation containing chemical constituents that have been extracted from a plant using a solvent. The resulting extract may contain a single compound or a mixture of several compounds, depending on the extraction process and the specific plant material used. These extracts are often used in various industries including pharmaceuticals, nutraceuticals, cosmetics, and food and beverage, due to their potential therapeutic or beneficial properties. The composition of plant extracts can vary widely, and it is important to ensure their quality, safety, and efficacy before use in any application.
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Officinalis7
- Sanguisorba officinalis L. - great burnet, burnet bloodwort Sanguisorba × poroshirensis S.Watan. (wikipedia.org)
- Sanguisorba × pseudo-officinalis Naruh. (wikipedia.org)
- Sanguisorba officinalis is used in traditional Chinese medicinal to treat gastrointestinal conditions and bleeding. (wikipedia.org)
- Sanguisorba officinalis var. (plantlust.com)
- id":4522538041480,"title":"Sanguisorba officinalis Little Angel Burnet","handle":"sanguisorba-officinalis-little-angel","description":"\u003cp\u003eCompact variegated plants with maroon flowers. (plantsinthecity.ca)
- In vitro anti-bactrical activity and its preliminary mechanism of action of the non-medicinal parts of Sanguisorba officinalis L. against Helicobacter pylori infection. (bvsalud.org)
- ETHNOPHARMACOLOGICAL RELEVANCE Sanguisorba officinalis L. (S. officinalis L.), known as Di Yu (DY) in Traditional Chinese Medicine (TCM), are used to treat burns , vomiting of blood , asthma , intestinal infections , and dermatitis . (bvsalud.org)
Burnet9
- A.Gray - annual burnet, prairie burnet, western burnet Sanguisorba applanata T.T.Yu & C.L.Li Sanguisorba armena Boiss. (wikipedia.org)
- Sanguisorba canadensis L. - Canadian burnet, white burnet Sanguisorba cretica Hayek Sanguisorba diandra (Hook.f. (wikipedia.org)
- Nordborg Sanguisorba dodecandra Moretti - Italian burnet Sanguisorba durui Yild. (wikipedia.org)
- Nordborg - Canary Islands burnet Sanguisorba minor Scop. (wikipedia.org)
- salad burnet, garden burnet, little burnet Sanguisorba obtusa Maxim. (wikipedia.org)
- Japanese burnet Sanguisorba occidentalis Nutt. (wikipedia.org)
- Sanguisorba minor, salad burnet, has similarly been used medicinally in Europe to control bleeding. (wikipedia.org)
- Small burnet (Poterium sanguisorba subsp. (eol.org)
- From the Callista (which means 'most beautiful' in Ancient Greek) collection this 100% silk fabric features silhouettes of beautiful seed heads from the Sanguisorba plant, commonly known as Burnet. (beckylee.co.nz)
Tenuifolia2
- Sanguisorba tenuifolia Fisch. (wikipedia.org)
- Sanguisorba Ruby Red was first seen in the garden as a seedling that arose in the Mill End borders and is likely to be a form of Sanguisorba tenuifolia. (knollgardens.co.uk)
Genus2
- Sanguisorba is a genus of flowering plants in the family Rosaceae native to the temperate regions of the Northern Hemisphere. (wikipedia.org)
- An Sanguisorba menziesii in nahilalakip ha genus nga Sanguisorba , ngan familia nga Rosaceae . (wikipedia.org)
Plants1
- Sanguisorba L." Plants of the World Online. (wikipedia.org)
Menziesii2
- An Sanguisorba menziesii [1] in uska species han Magnoliopsida nga ginhulagway ni Per Axel Rydberg . (wikipedia.org)
- Sanguisorba menziesii produces long, maroon red spikes of bottle-brush type flowers spikes with grey / green foliage. (calamazagnursery.co.uk)
Plant1
- ex Link Sanguisorba minor is a food plant for the larvae of the grizzled skipper (Pyrgus malvae) and the mouse moth (Amphipyra tragopoginis). (wikipedia.org)
Stipulata1
- Sanguisorba stipulata Raf. (wikipedia.org)
Hakusanensis1
- Sanguisorba hakusanensis Makino Sanguisorba hybrida (L.) Font Quer Sanguisorba indica (Gardner) Tirveng. (wikipedia.org)
Species2
- The following species are accepted: Sanguisorba albanica András. (wikipedia.org)
- The aim of this study was to investigate the method of combining Caspian Sea water with fresh water on the yield of Medicago sativa and Sanguisorba minor species. (waterjournal.ir)
Minor2
- Search: sanguisorba minor subsp. (eol.org)
- هدف این تحقیق، بررسی روش تلفیق آب دریای خزر با آب شیرین بر عملکرد گونههای Medicago sativa و Sanguisorba minor میباشد. (waterjournal.ir)
Garden1
- There is a large patch of Sanguisorba hakusanensi s planted to the west of the Garden in F05. (rbge.info)
Flowers1
- Bridal Bouquet Red & Pink Flowers Bridal Bouquet made from red and pink flowers like hydrangeas, roses, lysianthus, sanguisorba and. (nedadecorations.gr)
Made1
- Bridal Bouquet Sanguisorba Talinum Roses Panicum A Bridal Bouquet made from sanguisorba, talinum, roses, chrysanthemum, panicum and eucalyptus. (nedadecorations.gr)
Rosaceae2
- Sanguisorba is a genus of flowering plants in the family Rosaceae native to the temperate regions of the Northern Hemisphere. (wikipedia.org)
- Sanguisorba is a genus in the Rosaceae family containing about 18 species, which have been used to create thousands of hybrids. (whiteflowerfarm.com)
Poterium8
- Poterium sanguisorba L. (calflora.org)
- Poterium sanguisorba was introduced to the northern hemisphere from Euro-Asia for erosion control. (calflora.org)
- Poterium sanguisorba is a perennial, growing to over 2 feet tall with basal leaves 2-8 inches long and stem leaves reduced in size. (calflora.org)
- One is certainly first attracted to Poterium sanguisorba by its ball-head spike of strange flowers - attractively red filamentary. (calflora.org)
- Updated and re-directed to Poterium sanguisorba ssp balearicum . (ukwildflowers.com)
- Blodstillende Bibernelle (Poterium sanguisorba ssp. (biopix.dk)
- 27 plant name records match your search criteria Poterium sanguisorba . (theplantlist.org)
- Poterium sanguisorba Hook.f. (theplantlist.org)
Dodecandra1
- Sanguisorba dodecandra Moretti is an endemic plant of the Alps of the Lombardy region (Northern Italy). (unimontagna.it)
Perennials1
- Sanguisorba are perennials with attractive, pinnate leaves and branched stems bearing terminal spikes of small fluffy bottlebrush-like flowers. (mountvenusnursery.com)
Kishinamii2
- Sanguisorba japonensis (Makino) Kudô Sanguisorba × kishinamii Honda Sanguisorba lateriflora (Coss. (wikipedia.org)
- Sanguisorba × kishinamii Honda , Bot. (wikimedia.org)
Tall2
- A very tall and stately Sanguisorba flowering in late summer and into Autumn. (cloverhillrareplants.com.au)
- This high-fashion Sanguisorba was selected by Dutch plantsman Piet Oudolf for its deep ruby-red bobbles, perched on tall stiffer stems. (ballyrobertgardens.com)
Good1
- Spectacular repeat flowering sanguisorba with good, sturdy, upright habit seldom needing staking. (hoohouse.co.uk)