A plant species of the family CARYOPHYLLACEAE. It is a source of SAPONINS. The common name "Soapwort" is also used with VACCARIA. The common name of "Bouncing Bet" is occasionally used with VIOLA.
A plant genus of the family SAPINDACEAE that contain SAPONINS.
A plant genus of the family ROSACEAE whose members produce SAPONINS.
Ribosome inactivating proteins consisting of only the toxic A subunit, which is a polypeptide of around 30 kDa.
A type of glycoside widely distributed in plants. Each consists of a sapogenin as the aglycone moiety, and a sugar. The sapogenin may be a steroid or a triterpene and the sugar may be glucose, galactose, a pentose, or a methylpentose.
Semisynthetic conjugates of various toxic molecules, including RADIOACTIVE ISOTOPES and bacterial or plant toxins, with specific immune substances such as IMMUNOGLOBULINS; MONOCLONAL ANTIBODIES; and ANTIGENS. The antitumor or antiviral immune substance carries the toxin to the tumor or infected cell where the toxin exerts its poisonous effect.
A plant genus of the family Aloeaceae, order Liliales (or Asphodelaceae, Asparagales in APG system) which is used medicinally. It contains anthraquinone glycosides such as aloin-emodin or aloe-emodin (EMODIN).
A class of enzymes involved in the hydrolysis of the N-glycosidic bond of nitrogen-linked sugars.
The aglucon moiety of a saponin molecule. It may be triterpenoid or steroid, usually spirostan, in nature.
A subclass of anhydrides with the general structure of dihydrofurandione. They can be substituted on any carbon atom. They modify and inhibit proteins and enzymes and are used in the acylation of amino- and hydroxyl groups.
N-Glycosidases that remove adenines from RIBOSOMAL RNA, depurinating the conserved alpha-sarcin loop of 28S RIBOSOMAL RNA. They often consist of a toxic A subunit and a binding lectin B subunit. They may be considered as PROTEIN SYNTHESIS INHIBITORS. They are found in many PLANTS and have cytotoxic and antiviral activity.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
A 66-kDa peroxidase found in EOSINOPHIL granules. Eosinophil peroxidase is a cationic protein with a pI of 10.8 and is comprised of a heavy chain subunit and a light chain subunit. It possesses cytotoxic activity towards BACTERIA and other organisms, which is attributed to its peroxidase activity.
Proteins found in plants (flowers, herbs, shrubs, trees, etc.). The concept does not include proteins found in vegetables for which VEGETABLE PROTEINS is available.

Effects of a Quillaja saponaria extract on growth performance and immune function of weanling pigs challenged with Salmonella typhimurium. (1/8)

Ninety-six pigs (initially 8.9 kg and 24 d of age) were used in a 28-d experiment to determine the effects of Quillaja saponaria extract (QS) on weanling pig growth performance and immune function in response to enteric disease challenge with Salmonella typhimurium (ST). Experimental treatments were arranged in a 2 x 4 factorial with main effects of disease challenge (control vs ST-challenge) and dietary addition of QS (0, 125, 250, or 500 mg/kg). Pigs were fed QS diets for 14 d and then challenged orally with ST or sterile media. There were no differences in ADG or ADFI among dietary treatments, but gain/feed ratio (G/ F) was depressed (P < 0.06) in pigs fed 250 mg/kg QS. ST-challenge reduced ADG (P < 0.05), ADFI (P < 0.05), and G/F (P < 0.05) 1 wk after challenge. Daily estimates revealed reductions in feed intake in ST-infected pigs on d 2 to 5 following infection (P < 0.05), and rectal temperature was increased maximally 2 d following infection (P < 0.05). There was a marked decline in serum IGF-I during the 6 d after ST-infection (P < 0.05). ST-challenge produced a rise (P < 0.05) in serum haptoglobin on d 7 after challenge, and serum alpha1-acid glycoprotein (AGP) in ST-challenged pigs also was elevated (P < 0.05) above controls on d 7 and 14 after challenge. Serum immunoglobulin (Ig) M increased (P < 0.05) over time in both groups, and serum IgM of ST-challenged pigs was greater than controls on d 7 after challenge (P < 0.05). Serum IgG was not affected by enteric disease challenge; however, on d 7 and 14 after disease challenge, serum IgG for both groups was greater (P < 0.05) than on d 0. Dietary QS had no significant influence on any of the end points used to characterize the acute phase response to ST-challenge. Phagocytic cell function was depressed in pigs fed 250 (P < 0.05) and 500 (P < 0.05) mg/kg as compared to pigs fed 125 mg/kg QS. Yet, there was no difference in phagocytic function among pigs fed 0, 250, or 500 mg/kg QS. We conclude that this model of enteric disease invokes an acute phase response accompanied by decreases in feed intake and serum IGF-I. Furthermore, dietary QS, at the levels fed in this study, appears to offer little benefit to growth performance or immune function in the presence or absence of ST-challenge.  (+info)

The cytotoxic activity of ribosome-inactivating protein saporin-6 is attributed to its rRNA N-glycosidase and internucleosomal DNA fragmentation activities. (2/8)

Saporin-6 produced by the plant Saponaria officinalis belongs to the family of single chain ribosome-inactivating proteins. It potently inhibits protein synthesis in eukaryotic cells, by cleaving the N-glycosidic bond of a specific adenine in 28 S rRNA, which results in the cell death. Saporin-6 has also been shown to be active on DNA and induces apoptosis. In the current study, we have investigated the roles of rRNA depurination and the activity of saporin-6 on genomic DNA in its cytotoxic activity. The role of putative active site residues, Tyr(72), Tyr(120), Glu(176), Arg(179), and Trp(208), and two invariant residues, Tyr(16) and Arg(24), proposed to be important for structural stability of saporin-6, has been investigated in its catalytic and cytotoxic activity. These residues were mutated to alanine to generate seven mutants, Y16A, R24A, Y72A, Y120A, E176A, R179A, and W208A. We show that for the RNA N-glycosidase activity of saporin-6, residues Tyr(16), Tyr(72), and Arg(179) are absolutely critical; Tyr(120) and Glu(176) can be partially dispensed with, whereas Trp(208) and Arg(24) do not appear to be involved in this activity. The residues Tyr(72), Tyr(120), Glu(176), Arg(179), and Trp(208) were found to be essential for the genomic DNA fragmentation activity, whereas residues Tyr(16) and Arg(24) do not appear to be required for the DNA fragmentation. The study shows that saporin-6 possesses two catalytic activities, namely RNA N-glycosidase and genomic DNA fragmentation activity, and for its complete cytotoxic activity both activities are required.  (+info)

Saponin biosynthesis in Saponaria vaccaria. cDNAs encoding beta-amyrin synthase and a triterpene carboxylic acid glucosyltransferase. (3/8)

Saponaria vaccaria (Caryophyllaceae), a soapwort, known in western Canada as cowcockle, contains bioactive oleanane-type saponins similar to those found in soapbark tree (Quillaja saponaria; Rosaceae). To improve our understanding of the biosynthesis of these saponins, a combined polymerase chain reaction and expressed sequence tag approach was taken to identify the genes involved. A cDNA encoding a beta-amyrin synthase (SvBS) was isolated by reverse transcription-polymerase chain reaction and characterized by expression in yeast (Saccharomyces cerevisiae). The SvBS gene is predominantly expressed in leaves. A S. vaccaria developing seed expressed sequence tag collection was developed and used for the isolation of a full-length cDNA bearing sequence similarity to ester-forming glycosyltransferases. The gene product of the cDNA, classified as UGT74M1, was expressed in Escherichia coli, purified, and identified as a triterpene carboxylic acid glucosyltransferase. UGT74M1 is expressed in roots and leaves and appears to be involved in monodesmoside biosynthesis in S. vaccaria.  (+info)

Analysis of gypsogenin saponins in homeopathic tinctures. (4/8)

A relatively simple and short procedure for the quantitative determination of gypsogenin saponins was performed to evaluate homeopathic tinctures in which those compounds can be regarded as one of the active constituents. This method comprises partial hydrolysis of saponins, subsequent extraction of liberated prosaponin (gypsogenin 3-O-glucuronide) and its analysis by high performance liquid chromatography. Glycyrrhizic acid was used as an internal standard. This method was successfully applied to the analysis of mother tinctures obtained from Saponaria officinalis. Thus, the determination of triterpenoid saponins can be used as a convenient and sufficient method of standardization of selected homeopathic tinctures.  (+info)

Transition state analogues rescue ribosomes from saporin-L1 ribosome inactivating protein. (5/8)

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Immunotoxins and other conjugates containing saporin-s6 for cancer therapy. (6/8)

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Targeted tumor therapy by epidermal growth factor appended toxin and purified saponin: an evaluation of toxicity and therapeutic potential in syngeneic tumor bearing mice. (7/8)

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The two-step biosynthesis of cyclic peptides from linear precursors in a member of the plant family Caryophyllaceae involves cyclization by a serine protease-like enzyme. (8/8)

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"Saponaria" is not a term used in modern medical terminology. It is the name of a genus of plants in the primrose family, also known as soapwort. The roots and leaves of these plants contain saponins, which have been used historically for their soap-like properties to create lathers and for medicinal purposes such as mild skin irritation and cough suppressants. However, it is not commonly used in modern medical practice.

"Sapindus" is a botanical term that refers to a genus of trees in the soapberry family (Sapindaceae). These trees are native to warm temperate to tropical regions of the world. The fruit of these trees contains saponins, which have cleansing properties and have been used as a natural soap for washing.

However, "Sapindus" is not a medical term and does not have a specific medical definition. If you are looking for information about the medicinal uses or health benefits of Sapindus trees or their fruit, I would recommend consulting reliable sources of information on herbal medicine or speaking with a healthcare provider who has expertise in this area.

"Quillaja" is the common name for Quillaja saponaria, a species of tree that is native to Chile. The bark and extracts from the tree have been used in traditional medicine for various purposes.

In a medical context, "Quillaja" often refers to Quillaia extract or Quillaja saponins, which are derived from the bark of the tree. These extracts contain saponins, which are natural compounds with foaming properties. They have been used in medicine as an expectorant to help loosen mucus in the airways and make coughs more productive.

Quillaia extract is also used in some vaccines as an adjuvant, a substance that enhances the body's immune response to an antigen. The saponins in Quillaja stimulate the immune system and help the body mount a stronger response to the vaccine.

It's important to note that while Quillaia extract has been used in medicine for many years, more research is needed to fully understand its safety and effectiveness. As with any medication or supplement, it should only be used under the guidance of a healthcare provider.

Ribosome-inactivating proteins (RIPs) are a type of protein that can inhibit the function of ribosomes, which are the cellular structures responsible for protein synthesis. Ribosome-inactivating proteins are classified into two types: Type 1 and Type 2.

Type 1 Ribosome-Inactivating Proteins (RIPs) are defined as single-chain proteins that inhibit protein synthesis by depurinating a specific adenine residue in the sarcin-ricin loop of the large rRNA molecule within the ribosome. This results in the irreversible inactivation of the ribosome, preventing it from participating in further protein synthesis.

Type 1 RIPs are found in various plant species and have been identified as potential therapeutic agents for cancer treatment due to their ability to selectively inhibit protein synthesis in cancer cells. However, they can also be toxic to normal cells, which limits their clinical use. Examples of Type 1 RIPs include dianthin, gelonin, and trichosanthin.

Saponins are a type of naturally occurring chemical compound found in various plants, including soapwords, ginseng, and many others. They are known for their foaming properties, similar to that of soap, which gives them their name "saponin" derived from the Latin word "sapo" meaning soap.

Medically, saponins have been studied for their potential health benefits, including their ability to lower cholesterol levels, reduce inflammation, and boost the immune system. However, they can also have toxic effects in high concentrations, causing gastrointestinal disturbances and potentially damaging red blood cells.

Saponins are typically found in the cell walls of plants and can be extracted through various methods for use in pharmaceuticals, food additives, and cosmetics.

Immunotoxins are biomolecules that combine the specificity of an antibody with the toxicity of a toxin. They are created by chemically linking a monoclonal antibody (that recognizes and binds to a specific cell surface antigen) to a protein toxin (that inhibits protein synthesis in cells). The immunotoxin selectively binds to the target cell, gets internalized, and releases the toxin into the cytosol, leading to cell death. Immunotoxins have been explored as potential therapeutic agents for targeted cancer therapy and treatment of other diseases.

'Aloe' is the common name for a genus of succulent plants that belong to the family Asphodelaceae. The most widely recognized species is Aloe vera, which has been used for medicinal and therapeutic purposes for centuries.

Aloe vera, also known as "true aloe" or "medical aloe," contains a clear gel inside its leaves that is made up of 99% water and a complex mixture of glucomannans, acemannan, polymannose, anthraquinones, enzymes, sugars, sterols, vitamins, and minerals. This gel has been used topically to soothe skin irritations, burns, and other dermatological conditions due to its anti-inflammatory, moisturizing, and antimicrobial properties.

In addition to its topical uses, aloe vera extracts have also been studied for their potential internal health benefits, including improving digestion, boosting the immune system, and providing antioxidant effects. However, more research is needed to confirm these potential benefits and establish recommended dosages and safety guidelines.

It's important to note that not all aloe products are created equal, and some may contain additives or contaminants that can cause adverse reactions. Always consult with a healthcare professional before using aloe vera or any other natural remedy for medicinal purposes.

N-Glycosyl hydrolases (or N-glycanases) are a class of enzymes that catalyze the hydrolysis of the glycosidic bond between an N-glycosyl group and an aglycon, which is typically another part of a larger molecule such as a protein or lipid. N-Glycosyl groups refer to carbohydrate moieties attached to an nitrogen atom, usually in the side chain of an amino acid such as asparagine (Asn) in proteins.

N-Glycosyl hydrolases play important roles in various biological processes, including the degradation and processing of glycoproteins, the modification of glycolipids, and the breakdown of complex carbohydrates. These enzymes are widely distributed in nature and have been found in many organisms, from bacteria to humans.

The classification and nomenclature of N-Glycosyl hydrolases are based on the type of glycosidic bond they cleave and the stereochemistry of the reaction they catalyze. They are grouped into different families in the Carbohydrate-Active enZymes (CAZy) database, which provides a comprehensive resource for the study of carbohydrate-active enzymes.

It is worth noting that N-Glycosyl hydrolases can have both beneficial and detrimental effects on human health. For example, they are involved in the normal turnover and degradation of glycoproteins in the body, but they can also contribute to the pathogenesis of certain diseases, such as lysosomal storage disorders, where mutations in N-Glycosyl hydrolases lead to the accumulation of undigested glycoconjugates and cellular damage.

Sapogenins are steroid-like compounds that are naturally occurring in some plants, particularly in the sap of certain species. They are aglycones (non-sugar components) of saponins, which are glycosides (compounds with sugar molecules) known for their foaming properties.

Sapogenins have a steroidal structure and can be further categorized into two groups: spirostanol sapogenins and furostanol sapogenins. These compounds have potential therapeutic applications due to their anti-inflammatory, immunomodulatory, and cytotoxic properties. However, more research is needed to fully understand their mechanisms of action and potential benefits in medical treatments.

I'm sorry for any confusion, but "Succinic Anhydrides" is not a recognized medical term. Succinic anhydride is a chemical compound with the formula (CH2)2(CO)2O. It is used in organic synthesis as a dehydrating agent and acylating agent. If you're asking about a medical application or effect of succinic anhydride or its derivatives, I would need more specific information to provide an accurate and helpful response.

Ribosome-inactivating proteins (RIPs) are a type of protein that can inhibit the function of ribosomes, which are the cellular structures responsible for protein synthesis. Ribosomes are made up of two subunits, and RIPs work by depurinating a specific adenine residue in the sarcin-ricin loop of the large rRNA subunit, leading to the inhibition of protein synthesis and ultimately, cell death.

RIPs can be found in various organisms, including plants, bacteria, and fungi. Some RIPs have N-glycosidase activity, while others have both N-glycosidase and RNA N-hydroxylase activities. Based on their structure and mechanism of action, RIPs are classified into two types: type 1 and type 2.

Type 1 RIPs consist of a single polypeptide chain with N-glycosidase activity, while type 2 RIPs consist of two chains - an A chain with N-glycosidase activity and a B chain that acts as a lectin, facilitating the entry of the A chain into the cell.

RIPs have been studied for their potential use in cancer therapy due to their ability to inhibit protein synthesis in cancer cells. However, their toxicity to normal cells limits their therapeutic use. Therefore, researchers are exploring ways to modify RIPs to increase their specificity towards cancer cells while minimizing their toxicity to normal cells.

A plant extract is a preparation containing chemical constituents that have been extracted from a plant using a solvent. The resulting extract may contain a single compound or a mixture of several compounds, depending on the extraction process and the specific plant material used. These extracts are often used in various industries including pharmaceuticals, nutraceuticals, cosmetics, and food and beverage, due to their potential therapeutic or beneficial properties. The composition of plant extracts can vary widely, and it is important to ensure their quality, safety, and efficacy before use in any application.

Eosinophil peroxidase (EPO) is an enzyme that is primarily found in the granules of eosinophils, which are a type of white blood cell that plays a role in the immune response. EPO is involved in the destruction of certain types of parasites and also contributes to the inflammatory response in allergic reactions and other diseases.

EPO catalyzes the conversion of hydrogen peroxide to hypochlorous acid, which is a potent oxidizing agent that can kill or inhibit the growth of microorganisms. EPO also plays a role in the production of other reactive oxygen species, which can contribute to tissue damage and inflammation in certain conditions.

Elevated levels of EPO in tissues or bodily fluids may be indicative of eosinophil activation and degranulation, which can occur in various diseases such as asthma, allergies, parasitic infections, and some types of cancer. Measuring EPO levels can be useful in the diagnosis and monitoring of these conditions.

"Plant proteins" refer to the proteins that are derived from plant sources. These can include proteins from legumes such as beans, lentils, and peas, as well as proteins from grains like wheat, rice, and corn. Other sources of plant proteins include nuts, seeds, and vegetables.

Plant proteins are made up of individual amino acids, which are the building blocks of protein. While animal-based proteins typically contain all of the essential amino acids that the body needs to function properly, many plant-based proteins may be lacking in one or more of these essential amino acids. However, by consuming a variety of plant-based foods throughout the day, it is possible to get all of the essential amino acids that the body needs from plant sources alone.

Plant proteins are often lower in calories and saturated fat than animal proteins, making them a popular choice for those following a vegetarian or vegan diet, as well as those looking to maintain a healthy weight or reduce their risk of chronic diseases such as heart disease and cancer. Additionally, plant proteins have been shown to have a number of health benefits, including improving gut health, reducing inflammation, and supporting muscle growth and repair.

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