Scleredema Adultorum
A diffuse, non-pitting induration of the skin of unknown etiology that occurs most commonly in association with diabetes mellitus, predominantly in females. It typically begins on the face or head and spreads to other areas of the body, sometimes involving noncutaneous tissues. Often it is preceded by any of various infections, notably staphylococcal infections. The condition resolves spontaneously, usually within two years of onset. (From Dorland, 27th ed)
Scleredema adultorum. (1/12)
Scleredema adultorum is a rare connective tissue disorder reported usually following streptococcal infection, influenza, measles, and mumps. It has been reported occasionally following trauma and tuberculous lymphadenitis. This is a report of scleredema adultorum developing after chicken pox in an eight-year-old male child. The diagnosis was established by characteristic picture on skin biopsy using special stain. The patient had a benign course and a spontaneous recovery in two weeks. The case has been reported as the first case of scleredema adultorum developing after chicken pox. (+info)Scleredema diabeticorum--a case report. (2/12)
A 41 year male, diabetic on treatment presented with persistent erythema and. "taut" skin over neck and back since 1 year. The lesions showed symmetric and gradual progression. There was no history of prior sore throat. On examination effected skin was erythematous, woody hard and unpinchable. Scleredema diabeticorum (diutinum), although sharing clinical and historical features with Scleredema adultorum has no prodromal infection, is more extensive and affected individuals are characteristically obese, middle aged diabetics who often have accompanying microangiopathies and macroangiopathies. Recognition of scleredema by the physician has prognostic and therapeutic implications in the management of the coexisting diabetes. (+info)Scleroderma. (3/12)
A 72-year-old man with diabetes-associated scleredema is presented. The patient had a long history of diabetes mellitus that had been difficult to control with complications of retinopathy, nephropathy, and arteriosclerosis leading to myocardial infarcts and stroke. The scleredema has remained stable with 4 months of topical clobetasol ointment twice daily and biweekly physical therapy. Diseases associated with scleredema and therapeutic options are summarized. (+info)Widespread scleredema accompanied with a monoclonal gammopathy in a patient with advanced ankylosing spondylitis. (4/12)
Scleredema is a rare cutaneous mucinosis characterized by chronic diffuse induration of the skin, and it is occasionally associated with a monoclonal gammopathy (MG). Ankylosing spondylitis (AS) is noted to be another, chronic systemic inflammatory disorder of the axial skeleton that may accompany the MG. However, patients with scleredema and AS accompanied with a MG have not been reported in the literature. We here report a 40-yr-old man with scleredema and advanced AS accompanied with a MG of IgA-kappa protein. Widespread, long-standing scleredema has been developed over 10 yrs after the initial manifestation of AS. It is uncertain whether the coexistence of scleredema and AS is more than coincidental. (+info)Scleredema and diabetic sclerodactyly. (5/12)
A 40-year-old man presented with hardening of the skin of his hands and upper back, which had slowly worsened with time. His medical history included insulin-dependent diabetes mellitus since childhood. Histopathologic features of a biopsy specimen from the skin of his back showed a thick reticular dermis with collagen bundles in a haphazard array, which were separated by increased deposits of connective-tissue mucin. Scleredema and diabetic sclerodactyly are both well recognized skin findings that may occur in patients with diabetes mellitus. It is important to differentiate this condition from scleroderma. Treatment is difficult, and therefore many modalities have been used. This patient has improved with aminobenzoate, colchicine, and DMSO gel. (+info)Scleredema adultorum of Buschke: an under recognized skin complication of diabetes. (6/12)
Scleredema of Buschke or scleredema diabetorum is a skin complication of diabetes with deposits of collagen and aminoglycans in the dermis. This disease characterized by thickening and hardening of the skin, is usually localized in nape, back and shoulder areas. Consequences could be a decrease in motility of the shoulders and an impairment of respiratory function. Other possible complications are sleep apnoea syndrome and monoclonal gammapathy. Type 1 or type 2 diabetes may be associated with scleredema of Buschke in more than 50% of cases. Diabetes-related risk factors are long duration of the disease, presence of microangiopathy, overweight and need of insulin. Various specific treatments proposed in the literature are poorly validated. In most severe cases, radiation therapy may be useful. (+info)Identification of specific chondroitin sulfate species in cutaneous autoimmune disease. (7/12)
(+info)Cutaneous indurated plaque on the abdomen associated with diabetes mellitus. (8/12)
A woman, 74 years of age, presented to the emergency department with a lesion on the lower abdominal wall that had started a month earlier and was not associated with any other symptoms. Her family physician had treated it with emollient creams. Relevant past medical history included congestive heart failure, hypertension, hypertensive heart disease, pulmonary hypertension, mitral regurgitation, chronic atrial fibrillation, rosacea and diabetes mellitus that was being treated with oral hypoglycaemics (metformin). Physical examination revealed an area of skin on the lower abdominal wall that was ill-defined and indurated, with whitish papules and a 'cobblestone' appearance (Figure 1). (+info)Scleredema Adultorum, also known as Scleredema of Buschke, is a rare and chronic cutaneous fibrotic disorder characterized by thickening and hardening of the skin, typically involving the neck, shoulders, and upper trunk, resulting from excessive collagen deposition in the dermis.
Scleredema Adultorum is a rare and chronic connective tissue disorder, primarily characterized by thickening and hardening (induration) of the skin. The term "adultorum" refers to its occurrence in adults, although similar conditions can affect children.
The key features of Scleredema Adultorum include:
1. Skin induration: Thickening and hardening of the skin, often starting on the neck and upper back, before spreading to other areas such as the chest, abdomen, and extremities. The overlying skin may appear normal or have a woody texture.
2. Progression: The condition typically progresses in three stages - early, intermediate, and late. In the early stage, symptoms are usually limited to the skin. As the disease advances, it can affect deeper tissues, including muscles and nerves.
3. Associations: Scleredema Adultorum is often associated with certain medical conditions, such as diabetes mellitus, monoclonal gammopathy (abnormal proliferation of a single clone of plasma cells), and following infections like streptococcus.
The exact cause of Scleredema Adultorum remains unclear; however, it is believed to involve abnormalities in collagen metabolism and excessive deposition of extracellular matrix components, such as glycosaminoglycans, in the skin and underlying tissues. Treatment options are limited, and the prognosis varies depending on the severity and progression of the disease.