A form of pneumoconiosis resulting from inhalation of iron in the mining dust or welding fumes.
Conditions in which there is a generalized increase in the iron stores of body tissues, particularly of liver and the MONONUCLEAR PHAGOCYTE SYSTEM, without demonstrable tissue damage. The name refers to the presence of stainable iron in the tissue in the form of hemosiderin.
Hemosiderin is an iron-containing pigment that originates from the breakdown of hemoglobin and accumulates in tissues, primarily in macrophages, as a result of various pathological conditions such as hemorrhage, inflammation, or certain storage diseases.
Inanimate objects that become enclosed in the eye.
A disorder characterized by reduced synthesis of the beta chains of hemoglobin. There is retardation of hemoglobin A synthesis in the heterozygous form (thalassemia minor), which is asymptomatic, while in the homozygous form (thalassemia major, Cooley's anemia, Mediterranean anemia, erythroblastic anemia), which can result in severe complications and even death, hemoglobin A synthesis is absent.
Pyridine derivatives with one or more keto groups on the ring.
Organic chemicals that form two or more coordination links with an iron ion. Once coordination has occurred, the complex formed is called a chelate. The iron-binding porphyrin group of hemoglobin is an example of a metal chelate found in biological systems.
A disorder of iron metabolism characterized by a triad of HEMOSIDEROSIS; LIVER CIRRHOSIS; and DIABETES MELLITUS. It is caused by massive iron deposits in parenchymal cells that may develop after a prolonged increase of iron absorption. (Jablonski's Dictionary of Syndromes & Eponymic Diseases, 2d ed)

Spur cell anaemia and hepatic iron stores in patients with alcoholic liver disease undergoing orthotopic liver transplantation. (1/66)

BACKGROUND: Following orthotopic liver transplantation (OLT) histological examination of explant livers from patients with alcoholic liver disease (ALD) sometimes shows extensive iron deposits in a distribution suggestive of homozygous haemochromatosis. AIMS: To use haemochromatosis gene (HFE) assays to distinguish between ALD with notable siderosis and hereditary haemochromatosis. To evaluate the possible influence of spur cell haemolytic anaemia on hepatic iron loading. PATIENTS: Thirty seven patients with ALD were abstinent for at least six months prior to OLT. Twenty three patients had transferrin saturations greater than 55%, 16 also had increased serum ferritin (>350 micrograms/l). Eight of 37 (22%) explant livers had grade 3 or 4 hepatic iron deposition, predominantly in hepatocytes. Of these, four had a hepatic iron index greater than 1. 9 and most seemed to have spur cell haemolytic anaemia. METHODS: Mutation analysis for C282Y and H63D mutations was performed on DNA extracts from peripheral blood or explant liver. Spur cell haemolytic anaemia was diagnosed when the haemoglobin was 105 g/l in the presence of notable acanthocytosis. RESULTS: None of the eight patients with grade 3 or 4 hepatic iron had evidence of the C282Y mutation. Two of the eight were heterozygous for H63D. None of the remaining 28 patients tested showed homozygous HFE mutations. Spur cell anaemia was present in six of the eight patients with heavy iron deposition and only one of the remaining patients. CONCLUSIONS: The HFE mutation was not present in these patients with advanced ALD and heavy iron loading. Spur cell haemolytic anaemia provides an alternative potential mechanism for the heavy iron loading.  (+info)

Superficial siderosis of the CNS associated with multiple cavernous malformations. (2/66)

Superficial siderosis of the CNS due to chronic, recurrent subarachnoid hemorrhage is an uncommon and potentially debilitating disorder. The classic clinical manifestation is progressive bilateral sensorineural hearing loss (SNHL), although ataxia and pyramidal signs also are observed frequently. Cavernous malformations rarely present with subarachnoid hemorrhage. We describe an unusual case of a young patient who presented with progressive, bilateral SNHL who was found to have superficial CNS siderosis associated with multiple cavernous malformations.  (+info)

Increased hepatic iron deposition resulting from treatment of chronic hepatitis C with ribavirin. (3/66)

Increased levels of hepatic iron may impair the response of patients with chronic hepatitis C to treatment with interferon-alfa, but combination therapy with ribavirin has demonstrated efficacy in the treatment of hepatitis C. When used alone or with interferon-alfa, ribavirin may cause a dose-dependent reversible hemolytic anemia. We compared the extent and cellular localization of iron deposition in liver tissue from biopsy specimens obtained before and after 36 weeks of therapy with ribavirin or placebo for 59 patients with chronic hepatitis C. Paired slides were available for review from 26 ribavirin and 27 placebo recipients. Iron deposition was assessed using coded slides stained with Perls Prussian blue and was semi-quantitated in hepatocytes, Kupffer cells, and areas of fibrosis. The overall iron score fell by 0.96 in the placebo group and increased 1.69 in the ribavirin recipients. Iron was deposited mainly in hepatocytes; the hepatocyte iron score increased from 2.19 to 3.81 in the ribavirin group. The amount of iron staining in Kupffer cells declined in the placebo group and increased slightly in the ribavirin group. Iron changes in areas of fibrosis were minor and did not differ between groups. Increased total hepatic iron deposition occurred during a 9-month course of ribavirin. Ribavirin-associated hemolysis deposits iron preferentially in hepatocytes. This increased deposition of hepatic iron does not seem to affect the biochemical or histologic response to ribavirin therapy but may have implications for hepatocyte susceptibility to future injury.  (+info)

Diminished injury in hypotransferrinemic mice after exposure to a metal-rich particle. (4/66)

Using the hypotransferrinemic (Hp) mouse model, we studied the effect of altered iron homeostasis on the defense of the lung against a catalytically active metal. The homozygotic (hpx/hpx) Hp mice had greatly diminished concentrations of both serum and lavage fluid transferrin relative to wild-type mice and heterozygotes. Fifty micrograms of a particle containing abundant concentrations of metals (a residual oil fly ash) was instilled into wild-type mice and heterozygotic and homozygotic Hp animals. There was an oxidative stress associated with particle exposure as manifested by decreased lavage fluid concentrations of ascorbate. However, rather than an increase in lung injury, diminished transferrin concentrations in homozygotic Hp mice were associated with decreased indexes of damage, including concentrations of relevant cytokines, inflammatory cell influx, lavage fluid protein, and lavage fluid lactate dehydrogenase. Comparable to other organs in the homozygotic Hp mouse, siderosis of the lung was evident, with elevated concentrations of lavage fluid and tissue iron. Consequent to these increased concentrations of iron, proteins to store and transport iron, ferritin, and lactoferrin, respectively, were increased when assayed by immunoprecipitation and immunohistochemistry. We conclude that the lack of transferrin in Hp mice did not predispose the animals to lung injury after exposure to a particle abundant in metals. Rather, these mice demonstrated a diminished injury that was associated with an increase in the metal storage and transport proteins.  (+info)

Marginal siderosis and degenerative myelopathy: a manifestation of chronic subarachnoid hemorrhage in a horse with a myxopapillary ependymoma. (5/66)

Marginal siderosis is recognized in humans as an uncommon clinicopathologic entity characterized by degeneration of neural tissue at the surface of the brain and spinal cord, in association with the accumulation of hemosiderin, and resulting from chronic subarachnoid hemorrhage. The sources of hemorrhage are various and include neoplasms, malformations, cysts, and vasculopathy. Marginal siderosis of the spinal cord due to a myxopapillary ependymoma was diagnosed in a 19-year-old Dutch Warm Blood horse with clinical signs of myelopathy. There is only one previous report of marginal siderosis in the veterinary literature, also in a horse with clinical myelopathy.  (+info)

Two remarkable events in the field of intraocular foreign body: (1) The reversal of siderosis bulbi. (2) The spontaneous extrusion of an intraocular copper foreign body. (6/66)

Two unusual events concerning intraocular foreign bodies are presented. The first patient had an occult or unsuspected intraocular foreign body. He showed iridoplegia with mydriasis, siderosis iridis, and an intraocular piece of iron lying posteriorly near the retina. The foreign body was removed and the patient regained normal iris color and pupillary activity. His vision remains 20/15 six years postoperatively dispite ensuing retinal detachment one year after removal of the foreign body. The second patient was a young boy injured by a blasting cap explosion. He lost one eye from the injury and had a piece of intraocular brass in his left eye. In spite of the development of chalcosis and a mature cataract the lens gradually shrank in the pupillary space permitting a clear aphakic area and 20/25 vision. The brass fragment migrated forward and inferiorly and was finally extruded under the conjunctiva five years later, where it was removed and chemically analyzed by x-ray diffraction.  (+info)

MRI findings in a case of a superficial siderosis associated with an ependymoma. (7/66)

We present the imaging findings of superficial siderosis of the central nervous system associated with an ependymoma of the posterior fossa in a patient who presented with progressive bilateral sensorineural hearing loss and cerebellar ataxia. The ependymoma was a homogeneous well-defined mass of the fourth ventricle without hydrocephalus. Secondary siderosis due to chronic bleeding from the ependymoma appeared as linear hypointensity delineating the surface of the cortex, thin and subtle on spin-echo T2-weighted images, thick and obvious on gradient-echo T2-weighted images.  (+info)

Welder's pneumoconiosis: diagnostic usefulness of high-resolution computed tomography and ferritin determinations in bronchoalveolar lavage fluid. (8/66)

OBJECTIVE: We assessed the usefulness of high-resolution computed tomography (HRCT) and ferritin determinations in bronchoalveolar lavage (BAL) fluid for diagnosis of welder's pneumoconiosis. PATIENTS AND METHODS: We investigated 11 patients with welder's pneumoconiosis who were 34 to 67 years old and had been welding for 17 to 45 years. Ten patients were current smokers. We performed chest radiography and HRCT, and measured serum ferritin on all 11 patients. We obtained BAL fluid in 9 cases and transbronchial lung biopsy (TBLB) specimens in 7. Ferritin concentrations in BAL fluid were compared with those in welders without pneumoconiosis and other pneumoconiosis cases. RESULTS: HRCT revealed small centrilobular nodules in 9 cases, mild fibrotic changes in 3, and emphysematous changes in 3. Serum ferritin concentrations were elevated (>240 ng/ml) in 10 cases. Ferritin concentrations in BAL fluid were higher in welder's pneumoconiosis than in the occupational control group. CONCLUSION: In welder's pneumoconiosis, small centrilobular nodules are frequently seen on HRCT, and ferritin shows elevations in serum and/or BAL fluid. Such ferritin determinations are of value in diagnosis.  (+info)

Siderosis is a medical condition characterized by the abnormal accumulation of iron in various tissues and organs, most commonly in the lungs. This occurs due to the repeated inhalation of iron-containing dusts or fumes, which can result from certain industrial processes such as welding, mining, or smelting.

In the lungs, this iron deposit can lead to inflammation and fibrosis, potentially causing symptoms like coughing, shortness of breath, and decreased lung function. It is important to note that siderosis itself is not contagious or cancerous, but there may be an increased risk for lung cancer in individuals with severe and prolonged exposure to iron-containing particles.

While siderosis is generally non-reversible, the progression of symptoms can often be managed through medical interventions and environmental modifications to reduce further exposure to iron-containing dusts or fumes.

Hemosiderosis is a medical condition characterized by the abnormal accumulation of hemosiderin, an iron-containing protein, in various organs and tissues of the body. Hemosiderin is derived from the breakdown of hemoglobin, which is the oxygen-carrying protein in red blood cells. When there is excessive breakdown of red blood cells or impaired clearance of hemosiderin, it can lead to its accumulation in organs such as the liver, spleen, and lungs.

Hemosiderosis can be classified into two types: primary and secondary. Primary hemosiderosis is a rare condition that is caused by genetic disorders affecting red blood cells, while secondary hemosiderosis is more common and is associated with various conditions that cause excessive breakdown of red blood cells or chronic inflammation. These conditions include hemolytic anemias, repeated blood transfusions, liver diseases, infections, and certain autoimmune disorders.

The accumulation of hemosiderin can lead to tissue damage and organ dysfunction, particularly in the lungs, where it can cause pulmonary fibrosis, and in the heart, where it can lead to heart failure. Hemosiderosis is typically diagnosed through a combination of medical history, physical examination, and laboratory tests, including blood tests and imaging studies such as chest X-rays or MRI scans. Treatment of hemosiderosis depends on the underlying cause and may include medications, blood transfusions, or supportive care to manage symptoms and prevent complications.

Hemosiderin is a golden-brown pigment that consists of iron-containing protein complexes called ferritin and ferrikinase. It is insoluble in water and forms as a result of the breakdown of hemoglobin in the reticuloendothelial system, primarily in macrophages. Hemosiderin deposits can be found in various tissues and organs, such as the spleen, liver, and brain, under conditions of increased red blood cell destruction or impaired iron metabolism. These deposits are often associated with diseases such as hemochromatosis, thalassemia, and chronic inflammation.

Foreign bodies in the eye refer to any object or particle that is not normally present in the eye and becomes lodged in it. These foreign bodies can range from small particles like sand or dust to larger objects such as metal shavings or glass. They can cause irritation, pain, redness, watering, and even vision loss if they are not removed promptly and properly.

The symptoms of an eye foreign body may include:

* A feeling that something is in the eye
* Pain or discomfort in the eye
* Redness or inflammation of the eye
* Watering or tearing of the eye
* Sensitivity to light
* Blurred vision or difficulty seeing

If you suspect that you have a foreign body in your eye, it is important to seek medical attention immediately. An eye care professional can examine your eye and determine the best course of treatment to remove the foreign body and prevent any further damage to your eye.

Beta-thalassemia is a genetic blood disorder that affects the production of hemoglobin, a protein in red blood cells that carries oxygen throughout the body. Specifically, beta-thalassemia is caused by mutations in the beta-globin gene, which leads to reduced or absent production of the beta-globin component of hemoglobin.

There are two main types of beta-thalassemia:

1. Beta-thalassemia major (also known as Cooley's anemia): This is a severe form of the disorder that typically becomes apparent in early childhood. It is characterized by a significant reduction or absence of beta-globin production, leading to anemia, enlarged spleen and liver, jaundice, and growth retardation.
2. Beta-thalassemia intermedia: This is a milder form of the disorder that may not become apparent until later in childhood or even adulthood. It is characterized by a variable reduction in beta-globin production, leading to mild to moderate anemia and other symptoms that can range from nonexistent to severe.

Treatment for beta-thalassemia depends on the severity of the disorder and may include blood transfusions, iron chelation therapy, and/or bone marrow transplantation. In some cases, genetic counseling and prenatal diagnosis may also be recommended for families with a history of the disorder.

Pyridones are a class of organic compounds that contain a pyridone ring, which is a heterocyclic ring consisting of a six-membered ring with five carbon atoms and one nitrogen atom, with one oxygen atom attached to the nitrogen atom by a double bond. Pyridones can be found in various natural sources, including plants and microorganisms, and they also have important applications in the pharmaceutical industry as building blocks for drug design and synthesis. Some drugs that contain pyridone rings include antihistamines, anti-inflammatory agents, and antiviral agents.

Iron chelating agents are medications that bind to iron in the body, forming a stable complex that can then be excreted from the body. These agents are primarily used to treat iron overload, a condition that can occur due to frequent blood transfusions or certain genetic disorders such as hemochromatosis. By reducing the amount of iron in the body, these medications can help prevent or reduce damage to organs such as the heart and liver. Examples of iron chelating agents include deferoxamine, deferasirox, and deferiprone.

Hemochromatosis is a medical condition characterized by excessive absorption and accumulation of iron in the body, resulting in damage to various organs. It's often referred to as "iron overload" disorder. There are two main types: primary (hereditary) and secondary (acquired). Primary hemochromatosis is caused by genetic mutations that lead to increased intestinal iron absorption, while secondary hemochromatosis can be the result of various conditions such as multiple blood transfusions, chronic liver disease, or certain types of anemia.

In both cases, the excess iron gets stored in body tissues, particularly in the liver, heart, and pancreas, which can cause organ damage and lead to complications like cirrhosis, liver failure, diabetes, heart problems, and skin discoloration. Early diagnosis and treatment through regular phlebotomy (blood removal) or chelation therapy can help manage the condition and prevent severe complications.

Eye exposure to iron dust can also cause another form of siderosis, "ocular siderosis" or "siderosis bulbi", which can cause ... Pulmonary siderosis was first described in 1936 from X-ray images of the lungs of arc welders. The name siderosis comes from ... Pulmonary siderosis does not usually cause harmful scar tissue formation within the lungs, which is why it said to be non- ... Pulmonary siderosis is caused by repeated inhalation of fine iron or rust dust that happens usually over a number of years. ...
... which may be the most common cause of superficial siderosis, with superficial siderosis showing up many years later. In up to ... Superficial siderosis is largely considered a rare disease, with less than 270 total reported cases in scientific literature as ... Patients with superficial siderosis are often treated with deferiprone (brand name is Ferriprox), a lipid-soluble iron chelator ... Superficial siderosis is characterized by many symptoms resulting from brain damage: Sensorineural hearing loss- This is the ...
Siderosis is common.[citation needed] Microscopic examination of a biopsy of the small bowel in these patients shows villous ...
1959). Clinical aspects of ocular siderosis and hemosiderosis. AMA Archives of Ophthalmology. 62(2): 180. Cibis, P. A. (1961). ... 1957). Ocular effects of systemic siderosis. American Journal of Ophthalmology. 44(4): 158-172. Cibis, Paul A., Constant, ... Cibis, P. A., & Yamashita, T. (1959). Experimental aspects of ocular siderosis and hemosiderosis. American Journal of ...
Sometimes, the simpler term siderosis is used instead. Other definitions distinguishing hemochromatosis or hemosiderosis that ...
After 50 units have been transfused, or earlier in children, siderosis develops, with increased pigmentation of skin exposed to ... Brown induration Iron overload Siderosis Lu JP, Hayashi K (1995). "Transferrin receptor distribution and iron deposition in the ... "Beta-globin mutations are associated with parenchymal siderosis and fibrosis in patients with non-alcoholic fatty liver disease ...
"Haemophilus pittmaniae respiratory infection in a patient with siderosis: a case report". Journal of Medical Case Reports. 6 (1 ...
The level of siderosis seen in a liver biopsy can be graded by severity. Transfusional hemosiderosis is treated with a number ...
He is credited with the first description of superficial siderosis, published by him in 1908. He died on July 5, 1961, at his ...
DFP was also found to be significantly more effective than deferoxamine in treating myocardial siderosis in patients with ... controlled trial of deferiprone or deferoxamine in beta-thalassemia major patients with asymptomatic myocardial siderosis". ...
... formerly known as Bantu siderosis, was first observed among people of African descent in Southern Africa. Originally, this was ...
Anemia Siderosis List of hematologic conditions Hematopoietic stem cell transplantation Caudill JS, Imran H, Porcher JC, ...
Deposition of material Siderosis - iron deposition within ocular tissues due to a penetrating injury and a retained iron- ...
... cortical superficial siderosis). Other MRI indicators of CAA include white matter hyperintensities and cortical thinning. The ...
"Superficial Siderosis of the Central Nervous System Induced by a Single-Episode of Traumatic Subarachnoid Hemorrhage: A Study ... superficial siderosis, thrombosed aneurysm, phleboliths in vascular lesions, and some forms of calcification. T2*-weighted GRE ...
... siderosis and asbestosis (in particular dust from silica, coal, iron ore, zinc, aluminium or cement are common particulate ...
Siderosis Silicosis Byssinosis Hypersensitivity pneumonitis Bagassosis Bird fancier's lung Farmer's lung Beckett, W. S. (2000- ...
Bantu siderosis at NIH's Office of Rare Diseases (Articles with short description, Short description is different from Wikidata ... African iron overload, also known as Bantu siderosis or dietary iron overload, is an iron overload disorder first observed ...
ARIA-H superficial siderosis (hemosiderin) (15% vs 2%) Fall (15% vs 12%) Diarrhea (9% vs 7%) Confusion/delirium/altered mental ...
Weber syndrome Stuttering Subacute sclerosing panencephalitis Subcortical arteriosclerotic encephalopathy Superficial siderosis ...
... siderosis MeSH C08.381.483.600.760 - silicosis MeSH C08.381.483.600.760.125 - anthracosilicosis MeSH C08.381.483.600.760.750 - ...
... syndrome BANF acoustic neurinoma Bangstad syndrome Banki syndrome Bannayan-Zonana syndrome Banti's syndrome Bantu siderosis ...
... beryllium Siderosis - iron Byssinosis - Byssinosis is caused by cotton dust inhalation and typically demonstrates a different ...
... autosomal Siderosis Siegler-Brewer-Carey syndrome Silengo-Lerone-Pelizzo syndrome Silent sinus syndrome Silicosiderosis ...
... siderosis MeSH C21.447.800.834 - silicosis MeSH C21.447.800.834.201 - anthracosilicosis MeSH C21.447.800.834.752 - ...
Eye exposure to iron dust can also cause another form of siderosis, "ocular siderosis" or "siderosis bulbi", which can cause ... Pulmonary siderosis was first described in 1936 from X-ray images of the lungs of arc welders. The name siderosis comes from ... Pulmonary siderosis does not usually cause harmful scar tissue formation within the lungs, which is why it said to be non- ... Pulmonary siderosis is caused by repeated inhalation of fine iron or rust dust that happens usually over a number of years. ...
Siderosis Bulbi Siderosis bulbi is caused by retention and oxidation of an iron-containing intraocular foreign body. It results ... Siderosis may develop within weeks, but the course is variable depending on the iron content of the foreign body and its ... Siderosis may develop within weeks, but the course is variable depending on the iron content of the foreign body and its ... Siderosis bulbi is caused by retention and oxidation of an iron-containing intraocular foreign body. It results from the ...
Superficial Siderosis Awareness Wristband. Living with Superficial Siderosis. *Juliannes Superficial Siderosis Odyssey ... The Psychological Journey with Superficial Siderosis September 1, 2023. Living with Superficial Siderosis (SS) is not just a ... 2023 Superficial Siderosis Research Alliance Inc. All rights reserved. The SSRA is a 501(c)(3) Nonprofit EIN:84-2515094 ... When Neurology Has No Answers: My Journey Through the Maze of Superficial Siderosis September 5, 2023. A Nostalgic Look Back: ...
End-of-life donation of the brain and spinal cord tissue for superficial siderosis research is the most generous gift you can ... 2023 Superficial Siderosis Research Alliance Inc. All rights reserved. The SSRA is a 501(c)(3) Nonprofit EIN:84-2515094 ... By improving the understanding of superficial siderosis and the pathophysiology, research will explain the functional changes ... Sign up for Superficial Siderosis Research Alliance Newsletter. .widget_mailchimpsf_widget .widget-title { line-height: 1.4em; ...
Living With Superficial Siderosis. Saturday morning may have begun at our local community urgent care but it soon turned into a ... Superficial Siderosis 2015-2016 Getting a diagnosis was the first step. After about a year of health deterioration, multiple ... The Superficial Siderosis Research Alliance (SSRA) is a volunteer organization run by patients, caregivers, and friends, ... Metabolic stress is not a friend to the very young, elderly, or those whove been dealing with superficial siderosis for… ...
Superficial siderosis misdiagnosed as idiopathic bilateral neurosensorial deafness. HA González-Usigli et al., BMJ Case Reports ... Treatment of superficial siderosis with iron chelation therapy. Gemma Cummins et al., BMJ Case Reports, 2013 ... Superficial siderosis following spontaneous intracranial hypotension. Alastair J S Webb et al., Practical Neurology, 2015 ... Classical infratentorial superficial siderosis of the central nervous system: pathophysiology, clinical features and management ...
Superficial Siderosis and compassionate allowance Tag Archives - Georgia Disability Lawyer Blog ... Superficial Siderosis of the Central Nervous System is not a genetic disease and can occur as a result of surgery, trauma, or ... The Social Security Administration (SSA) recently added Superficial Siderosis of the Central Nervous System to its ...
... Subhaharan D ... Gastric Siderosis; Iron Tablets; Iron Overload. Introduction. Iron is predominantly used in the production of hemoglobin and ... The increased deposition of iron in gastric mucosa is known as gastric siderosis. We describe a case of a 69-year-old woman ... Kothadia JP., Arju R., Kaminski M (2016) Gastric siderosis: an under-recognized and rare clinical entity. SAGE Open Med 4: ...
Siderosis. *Stannosis. 503 Pneumoconiosis due to other inorganic dust *Aluminosis (of lung) ...
African siderosis. Additional Information & Resources. Genetic and Rare Diseases Information Center. *African iron overload ...
Salt Lake City, Utah 84132 801-585-7575. ...
Superficial siderosis. Fishman RA. Fishman RA. Ann Neurol. 1993 Nov;34(5):635-6. doi: 10.1002/ana.410340502. Ann Neurol. 1993. ...
ARIA-H superficial siderosis 1 focal area of. superficial siderosis 2 focal areas of superficial siderosis , 2 focal areas of ... The maximum radiographic severity of ARIA-H superficial siderosis in patients treated with ADUHELM was mild in 7% (79/1105) of ... superficial siderosis, and history of diffuse white matter disease). Vasogenic edema could also be suggestive of cerebral ... microhemorrhage or superficial siderosis) was highest in ApoE ε4 homozygotes 20% (36/182), compared to heterozygotes 4% (21/564 ...
... the hepatocytes may show siderosis. Scarring from macrophages, which contain high levels of stainable iron, may be present. ...
Siderosis. References. * Alward, W.L.M. Glaucoma: The Requisites in Ophthalmology. St Louis: Mosby Inc., 2000. ...
Siderosis, from inhaling iron from mines or welding fumes. *Silicosis, from inhaling silica dust ...
Incidence of cardiac complications in patients with cardiac siderosis. NHLI London. Cardiac complications in thalassaemia ...
Superficial Siderosis Research Alliance. Suquino, Inc. Susan G. Komen. Talkiatry. Talkspace. TECHMEDO. Teladoc Health. ...
Diverging pathophysiology in superficial siderosis with proximal upper limb amyotrophy. Iwase R, Kanouchi T, Yoshii T, Ishiguro ...
Superficial Siderosis of the Central Nervous System. *Tetrasomy 18p. Established in 2008, the CAL program has developed into a ...
Electro-oculogram (diabetic retinopathy, siderosis retinae, vitiliginous maculopathy, shallow retinal pigment epithelial ...
... or superficial siderosis (17.3% vs 9%); amyloid-related imaging abnormalities with edema or effusions (12.6% vs 1.7%); headache ...
Although the term "siderosis" strictly just means any deposition of surplus iron in the body, when used as a stand-alone term ...
Both of the cases examined presented welders siderosis. The large number of aluminum particles identified in 1 of 2 could ...
Superficial Siderosis due to Pseudomeningocele. Ken-ya Murata, Shinji Imae, Hideto Miwa, Tomoyoshi Kondo ...
A. Roghi, M. D. Cappellini, J. C. Wood et al., "Absence of cardiac siderosis despite hepatic iron overload in Italian patients ... Cardiac siderosis is of integral importance in management decisions in TDT as it is a major cause of morbidity and mortality; ... a closer look at the role of siderosis," Annals of Hepatology, vol. 12, no. 1, pp. 142-146, 2013. ...
ARIA with hemosiderin deposition (ARIA-H), which includes cerebral hemorrhage and superficial siderosis, occurred in 17%. ...
  • Welcome to the "Contact the Superficial Siderosis Research Alliance" page. (livingwithss.com)
  • The Superficial Siderosis Research Alliance (SSRA) is a volunteer organization run by patients, caregivers, and friends, dedicated to raising awareness, supporting medical research, and providing resources for those affected by this ultra-rare neurodegenerative disorder. (livingwithss.com)
  • When used without qualification, it usually refers to an environmental disease of the lung, also known more specifically as pulmonary siderosis or Welder's disease, which is a form of pneumoconiosis. (wikipedia.org)
  • Pulmonary siderosis was first described in 1936 from X-ray images of the lungs of arc welders. (wikipedia.org)
  • Mild to moderate scarring of the lungs has been found in unusual cases of pulmonary siderosis. (wikipedia.org)
  • Because of this, it is not known for certain whether the inhalation of pure iron or rust can cause detrimental scarring of the lungs that has been seen in some cases of pulmonary siderosis. (wikipedia.org)
  • Still, studies have shown lack of silica in tissue samples collected from people with pulmonary siderosis. (wikipedia.org)
  • Pulmonary siderosis is caused by repeated inhalation of fine iron or rust dust that happens usually over a number of years. (wikipedia.org)
  • Pulmonary siderosis causes changes within the lungs that are clearly visible in tissue samples, x-ray images and other radiological studies. (wikipedia.org)
  • There is no cure for pulmonary siderosis or other interstitial lung diseases. (wikipedia.org)
  • Outcome of pulmonary siderosis is often good if the inhalation of iron or rust dust is permanently avoided. (wikipedia.org)
  • Still, it is not known if pulmonary siderosis causes cancer in welders specifically or if these cases of cancer appear due to entirely different factors. (wikipedia.org)
  • Although the term " siderosis " strictly just means any deposition of surplus iron in the body, when used as a stand-alone term it usually refers to pulmonary siderosis. (radiopaedia.org)
  • Chronic iron overload may arise primarily in genetic haemochromatosis in which there there is excessive iron absorption, or secondary to excessive intake from transfusions (transfusional siderosis), or to alcoholic liver cirrhosis. (sas-centre.org)
  • Transfusional siderosis is treated by subcutaneous infusion of desferrioxamine. (sas-centre.org)
  • Eye exposure to iron dust can also cause another form of siderosis, "ocular siderosis" or "siderosis bulbi", which can cause eye discoloration, but also eye damage, like cataracts and night blindness. (wikipedia.org)
  • Siderosis bulbi is caused by retention and oxidation of an iron-containing intraocular foreign body. (atlasrleye.com)
  • The foreign body should be removed before irreversible siderosis bulbi occurs. (atlasrleye.com)
  • By improving the understanding of superficial siderosis and the pathophysiology, research will explain the functional changes at a cellular level that are occurring within an individual due to superficial siderosis. (livingwithss.com)
  • Dr. Michael Levy, Harvard University and all hospitals involved in this project intend the tissue collected be used to further the work towards understanding the pathophysiology of the disease identified as superficial siderosis and once a better understanding is met to continue using available tissue and data in pursuit of improving treatments that might possibly one day help patients heal. (livingwithss.com)
  • Diverging pathophysiology in superficial siderosis with proximal upper limb amyotrophy. (nih.gov)
  • Both of the cases examined presented welder's siderosis. (cdc.gov)
  • Siderosis is the deposition of excess iron in body tissue. (wikipedia.org)
  • While we refer to incontinence as a symptom, it may be considered "secondary to superficial siderosis" because it results from the damage or dysfunction the deposition of iron causes. (livingwithss.com)
  • The increased deposition of iron in gastric mucosa is known as gastric siderosis. (ospublishers.com)
  • Rare adverse effects include chronic gastritis and deposition of iron in the gastric mucosa, known as gastric siderosis. (ospublishers.com)
  • Functional damage to the retina occurs at a very early stage, before extensive siderosis is apparent, and before stainable iron is detected in retinal tissues. (atlasrleye.com)
  • Superficial Siderosis 2015-2016 Getting a diagnosis was the first step. (livingwithss.com)
  • Idiopathic pulmonary haemosiderosis - a disease caused by lung capillary bleeding Hemosiderosis - accumulation of hemosiderin in body Superficial siderosis - accumulation of hemosiderin in brain Iron deficiency - also known as sideropenia Iron overload - accumulation of iron in body from any cause African iron overload Doig AT, Mclaughlin AI (1936). (wikipedia.org)
  • 1947. Argyro-siderosis of the lungs in silver finishers. (cdc.gov)
  • End-of-life donation of the brain and spinal cord tissue for superficial siderosis research is the most generous gift you can make. (livingwithss.com)
  • Stress And Depression Have you ever wondered which is the most frequent and sometimes incapacitating superficial siderosis symptom? (livingwithss.com)
  • 10%) in the LEQEMBI group were infusion reactions, ARIA-H (combined cerebral microhemorrhages, cerebral macrohemorrhages, and superficial siderosis), ARIA-E (edema/effusion), headache, and fall. (eisai.com)
  • A Nostalgic Look Back: Celebrating Success Stories for SS MonthOriginally published in April 2018, we're taking a moment during Superficial Siderosis Month to revisit some of the most inspiring personal journeys that have graced our pages. (livingwithss.com)
  • The name siderosis comes from Ancient Greek word for iron, sídēr(os), and has an -osis suffix. (wikipedia.org)
  • Siderosis may develop within weeks, but the course is variable depending on the iron content of the foreign body and its location. (atlasrleye.com)
  • In siderosis the lens epithelium takes on a yellow-brown or rusty appearance, from minute dots of intracellular iron. (atlasrleye.com)
  • Join us in our journey towards a future where a Superficial Siderosis diagnosis is no longer a life-altering condition. (livingwithss.com)
  • Most common adverse reactions (at least 10% and higher incidence compared to placebo): ARIA-Edema, headache, ARIA-H microhemorrhage, ARIA-H superficial siderosis, and fall. (nih.gov)
  • This is your direct line to the SSRA, a dedicated community of researchers, advocates, and supporters committed to advancing the understanding and treatment of superficial siderosis. (livingwithss.com)
  • Herein, we report a case of incidental finding of gastric siderosis in the workup of dyspepsia. (ospublishers.com)
  • The patient was diagnosed with incidental finding of gastric glandular siderosis. (ospublishers.com)
  • Cortical superficial siderosis (cSS) was associated with higher mRS at follow-up. (hindawi.com)
  • They focused on cerebral microbleeds (CMBs), white matter changes (WMHs), and cortical superficial siderosis (cSS) [ 6 ]. (hindawi.com)
  • Association of cortical superficial siderosis with post-stroke epilepsy. (amedeo.com)
  • Siderosis is sometimes associated with silicosis among iron ore miners if the exposure to free silica is severe enough to cause fibrotic changes and subsequent deterioration of the pulmonary function. (digitalfire.com)
  • When used without qualification, it usually refers to an environmental disease of the lung, also known more specifically as pulmonary siderosis or Welder's disease, which is a form of pneumoconiosis. (wikipedia.org)
  • It has been named siderosis, iron pneumoconiosis, hematite pneumoconiosis, iron pigmentation of the lung, and "arc welder's lung" , reflecting the fact that it has been seen in many occupational groups exposed to iron oxide fumes, including silver polishers. (digitalfire.com)
  • 3.Ding J, Sieminski S, Yoganathan, P. Resolution of ocular siderosis glaucoma following removal of 30 year old intraocular foreign body. (kresgeeye.org)
  • Clinical expression of both sporadic and familial porphyria cutanea tarda most often requires exposure to environmental or infectious agents or the presence of coexisting conditions that adversely affect hepatocytes and result in hepatic siderosis. (medscape.com)
  • Whilst iron loading from blood transfusions may cause dilated cardiomyopathy in conditions such as thalassemia, the in-vivo prevalence of myocardial siderosis in HC is unclear, and its relation to left ventricular (LV) dysfunction is controversial. (nih.gov)
  • Most previous data on myocardial siderosis in HC has come from post-mortem studies. (nih.gov)
  • Overall however, the relation between myocardial siderosis and ferritin was weak (R2 0.20, p = 0.011). (nih.gov)
  • In the 10 genetically unconfirmed HC patients, 1 patient had mild myocardial siderosis but normal EF. (nih.gov)
  • Pulmonary siderosis was first described in 1936 from X-ray images of the lungs of arc welders. (wikipedia.org)
  • Mild to moderate scarring of the lungs has been found in unusual cases of pulmonary siderosis. (wikipedia.org)
  • Because of this, it is not known for certain whether the inhalation of pure iron or rust can cause detrimental scarring of the lungs that has been seen in some cases of pulmonary siderosis. (wikipedia.org)
  • Still, studies have shown lack of silica in tissue samples collected from people with pulmonary siderosis. (wikipedia.org)
  • Pulmonary siderosis is caused by repeated inhalation of fine iron or rust dust that happens usually over a number of years. (wikipedia.org)
  • Pulmonary siderosis causes changes within the lungs that are clearly visible in tissue samples, x-ray images and other radiological studies. (wikipedia.org)
  • There is no cure for pulmonary siderosis or other interstitial lung diseases. (wikipedia.org)
  • Outcome of pulmonary siderosis is often good if the inhalation of iron or rust dust is permanently avoided. (wikipedia.org)
  • Still, it is not known if pulmonary siderosis causes cancer in welders specifically or if these cases of cancer appear due to entirely different factors. (wikipedia.org)
  • Idiopathic pulmonary haemosiderosis - a disease caused by lung capillary bleeding Hemosiderosis - accumulation of hemosiderin in body Superficial siderosis - accumulation of hemosiderin in brain Iron deficiency - also known as sideropenia Iron overload - accumulation of iron in body from any cause African iron overload Doig AT, Mclaughlin AI (1936). (wikipedia.org)
  • Siderosis from iron dust inhalation has been found after prolonged exposure. (osha.gov)
  • Based on the first 69 published reports of superficial siderosis, it was calculated that 50% of cases are caused by an idiopathic chronic subarachnoid hemorrhage originating from an occult source, while the other 50% of cases are secondary to a known cause of subarachnoid hemorrhage such as a CNS tumor, arteriovenous malformation, or trauma. (medscape.com)
  • Other less common causes of chronic subarachnoid hemorrhage leading to superficial siderosis are post-surgical changes related to neurosurgeries (7%), brachial plexus injury (6%), amyloid angiopathy (3%), and chronic subdural hematomas. (medscape.com)
  • If 10 or more new incident microhemorrhages or greater than 2 focal areas of superficial siderosis (radiographic severe ARIA-H) are observed, treatment may be continued with caution only after a clinical evaluation and a follow-up MRI demonstrates radiographic stabilization (i.e., no increase in size or number of ARIA-H). (drugs.com)
  • Cranial MRI showed symmetric thin rims of low signal intensity in T2- and T2*-weighted images in the cortex of the sylvian fissures, of the cerebellar hemispheres and vermis, and in the quadrigeminal plate consistent with superficial siderosis of the CNS. (nih.gov)
  • MR scan of brain with susceptibility-weighted imaging (figure 1A) and T 2 -weighted imaging (figure 1B) showed superficial siderosis involving the Sylvian fissures, brainstem structures, cerebellar sulci and surrounding the third and lateral ventricles. (bmj.com)
  • Superficial siderosis was first described almost 100 years ago, but only a handful of cases appeared in the literature before the widespread use of MRI enabled physicians to make the diagnosis without a biopsy, and to discover incidental asymptomatic cases. (medscape.com)
  • In addition to greatly improving the chances of an early diagnosis of superficial siderosis, the wide availability of MRI has revolutionized our understanding of the etiology of the condition. (medscape.com)
  • Before you post any information about someone living with a superficial siderosis diagnosis, please ensure that the individual has agreed to have their diagnosis or medical status shared publicly. (livingwithss.com)
  • Patients must rely on the personal and individualized medical advice of their qualified healthcare professionals before seeking any information related to your particular diagnosis or treatment of superficial siderosis or associated symptoms. (livingwithss.com)
  • Despite extensive imaging, a source of bleeding is often not evident during the evaluation of patients with superficial siderosis (SS) of the central nervous system. (ajnr.org)
  • Living With Superficial Siderosis and the SSRA is not a medical provider or healthcare facility and thus can neither diagnose superficial siderosis or associated symptoms nor endorse or recommend any specific medical treatments. (livingwithss.com)
  • What are the symptoms of Siderosis? (mysds.ca)
  • Siderosis does not often have symptoms. (mysds.ca)
  • The younger daughter had vitreal deposits, sensorimotor polyneuropathy, and acute sensorineural hearing but no evidence of siderosis on cranial MRI. (nih.gov)
  • Localization of specialized cells within the cerebellum, brainstem, and spinal cord to sequester heme explains the predisposition of these CNS structures to be most adversely affected in cases of superficial siderosis. (medscape.com)
  • Our social platforms are safe spaces for sharing and discussion, and tools the superficial siderosis community can use to support people with superficial siderosis and fight this disease. (livingwithss.com)
  • Gastric siderosis: An under-recognized and rare clinical entity. (nih.gov)
  • Modern technology in scanning just diagnosed my hearing loss four years ago - it's due to Superficial Siderosis, a rarely diagnosed condition due to a brain bleed within the cerebral spinal fluid, as a result of the tumour removal. (rnid.org.uk)
  • Most common adverse reactions (at least 10% and higher incidence compared to placebo): ARIA-Edema, headache, ARIA-H microhemorrhage, ARIA-H superficial siderosis, and fall. (nih.gov)
  • Superficial siderosis is a radiological or pathological condition in which hemosiderin-a product of the breakdown of blood-is deposited in the subpial layer of the CNS, which typically leads to progressive and irreversible neurological dysfunction. (medscape.com)
  • The SSRA/LWSS serves people living with superficial siderosis throughout the world. (livingwithss.com)
  • We maintain a presence on several social media sites as part of our commitment to transparency and to keep those in the superficial siderosis community apprised of our news and activities. (livingwithss.com)