Pulmonary or extrapulmonary infection caused by MYCOBACTERIUM TUBERCULOSIS or nontuberculous mycobacteria in a patient with silicosis.

Mortality from lung cancer among silicotic patients in Sardinia: an update study with 10 more years of follow up. (1/12)

OBJECTIVES: To evaluate the association between silica, silicosis and lung cancer, the mortality of 724 patients with silicosis, first diagnosed by standard chest x ray film between 1964 and 1970, has been analysed by a cohort study extended to 31 December 1997. METHODS: Smoking and detailed occupational histories were available for each member of the cohort as well as the estimated lifetime exposure to respirable silica dust and radon daughters. Two independent readers blindly classified standard radiographs according to the 12 point International Labour Organisation (ILO) scale. Lung function tests meeting the American Thoracic Society's criteria were available for 665 patients. Standardised mortality ratios (SMRs) for selected causes of death were based on the age specific Sardinian regional death rates. RESULTS: The mortality for all causes was significantly higher than expected (SMR 1.35, 95% confidence interval (95% CI) 1.24 to 1.46) mainly due to tuberculosis (SMR 22.0) and to non-malignant chronic respiratory diseases (NMCRD) (SMR 6.03). All cancer deaths were within the expected numbers (SMR 0.93; 95% CI 0.76 to 1.14). The SMR for lung cancer was 1.37 (95% CI 0.98 to 1.91, 34 observed), increasing to 1.65 (95% CI 0.98 to 2.77) allowing for 20 years of latency since the first diagnosis of silicosis. Although mortality from NMCRD was strongly associated to the severity of radiological silicosis and to the extent of the cumulative exposure to silica, SMR for lung cancer was weakly related to the ILO categories and to the cumulative exposure to silica dust only after 20 years of lag interval. A significant excess of deaths from lung cancer (SMR 2.35) was found among silicotic patients previously employed in underground metal mines characterised by a relatively high airborne concentration of radon daughters and among ever smokers who showed an airflow obstruction at the time of the first diagnosis of silicosis (SMR 3.29). Mortality for lung cancer related to exposure was evaluated with both the Cox's proportional hazards modelling within the entire cohort and a nested case-control study (34 cases of lung cancer and 136 matched controls). Both multivariate analyses did not show any significant association with cumulative exposure to silica or severity of silicosis, but confirmed the association between mortality for lung cancer and relatively high exposure to radon, smoking, and airflow obstruction as significant covariates. CONCLUSIONS: The findings indicate that the slightly increased mortality for lung cancer in this cohort of silicotic patients was significantly associated with other risk factors-such as cigarette smoking, airflow obstruction, and estimated exposure to radon daughters in underground mines-rather than to the severity of radiological silicosis or to the cumulative exposure to crystalline silica dust itself.  (+info)

Mortality due to silico-tuberculosis and lung cancer among 200 whetstone cutters. (2/12)

The objective of the present study was to examine if the mortality due to tuberculosis and cancer in the lungs was elevated in a cohort of 200 male whetstone cutters. 1955-1995 death certificate-based mortality data on the cohort were available, and the data were reviewed in the present study for mortality due to the two diseases to calculate standardized mortality ratios (SMR) in reference to the health statistics of Kyoto prefecture, where the cohort lived. Among the 200 cohort members, 99 men deceased during the observation period, the deaths including 10 cases of lung tuberculosis (of which 9 cases had silicosis together), 20 cases of all malignancies, and 6 cases of lung cancer (5 cases with silicosis). There was a significant elevation in the mortality due to lung tuberculosis (SMR = 3.47) although SMR for all causes was not elevated (1.10). There was no significant change in SMR for all malignancies (0.78), whereas SMR for lung cancer (1.24) tended to be elevated although insignificantly. Lung tuberculosis was a significant complication of silicosis in 1955-1995. Possible elevation in lung cancer SMR among this cohort needs further studies.  (+info)

OPEN LUNG BIOPSY. (3/12)

Steady improvement in the diagnostic appraisal of obscure pulmonary and mediastinal disease has permitted more intelligent treatment, better prognosis, and where necessary more accurate assessment of compensability. Open lung biopsy is designed to obtain material for pathological study when there is no pleural, mediastinal, or airway lesion on which to base a working diagnosis.A study of 54 patients in whom lung biopsy was performed at the Toronto General Hospital and Weston Sanatorium is reported. A positive tissue diagnosis was obtained in approximately 75%. The procedure is considered relatively innocuous if sensible selection is exercised to exclude patients with terminal disease, particularly that associated with severe cardiorespiratory insufficiency. No major complications occurred in this series. It is concluded that open lung biopsy might reasonably receive much wider application than in the past in cases in which a definite diagnosis cannot otherwise be made.  (+info)

Spirometric measurements among quartz stone ex-workers of Gujarat, India. (4/12)

The present cross sectional study was carried out among 134 ex-workers from quartz stone crushing units. Using the interview technique as a tool for data collection, demographic and occupational details of the subjects were recorded on the predesigned proforma. Standard diagnostic criteria were used for diagnosing silicosis and silico-tuberculosis. The pulmonary functions of the subjects were measured with Spirovit SP-10. The mean age of the males was found to be 33.18 +/- 10.39 yr and that of the females was 30.10 +/- 9.3 yr and for the whole group was 31.77 +/- 9.99 yr. Mean duration of exposure was 2.74 +/- 1.65 yr. The study variables included age, sex, duration of exposure, smoking and respiratory morbidity. Forced Vital Capacity (FVC) which suggests lung parenchymal disorders was found to be significantly reduced with female sex, presence of smoking, increasing duration of exposure and presence of pneumoconiosis, whereas the lung function parameters indicating the status of airways were found to be significantly reduced with all the factors. Therefore, it was concluded that quartz stone workers exposed to approximately 100% free silica had deteriorated lung function which can be attributed mainly to respiratory disorders along with other epidemiological factors such as age, sex, duration of exposure and smoking.  (+info)

Progressive massive fibrosis in silica-exposed workers. High-resolution computed tomography findings. (5/12)

OBJECTIVE: To evaluate the radiological characteristics of conglomerate masses using high-resolution computed tomography of the chest. METHODS: From among the patients treated between 1986 and 2004 at the Antonio Pedro University Hospital, 75 patients with silicosis and massive fibrosis, most working in the field of sandblasting, were selected for study. These patients were submitted to a clinical evaluation, chest X-ray and high-resolution computed tomography of the chest. RESULTS: In more than half of the patients with accelerated silicosis, the chest X-ray revealed large type B and C opacities, denoting the severity of the disease in those patients. In 1 case, a unilateral mass simulating lung cancer was observed. High-resolution computed tomography scans of the chest were acquired for 44 patients. In most cases (88.6%), the masses were located in the superior and posterior thirds of the lung. Common findings within the masses included air bronchograms (in 70.4%) and calcifications (in 63.6%). A history of tuberculosis was reported by 52% of the patients. CONCLUSION: In the vast majority of cases, the masses were bilateral, predominantly located in the superior and posterior regions of the lung, featuring air bronchograms and interposed calcifications. Concomitant calcification of the mediastinal and hilar lymph nodes was another common finding. Exposure to high concentrations of dust and having a history of tuberculosis were considered significant risk factors for the development of progressive massive fibrosis.  (+info)

Tuberculosis and silicosis: epidemiology, diagnosis and chemoprophylaxis. (6/12)

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Mortality experience of haematite mine workers in China. (7/12)

The mortality risk of iron ore (haematite) miners between 1970 and 1982 was investigated in a retrospective cohort study of workers from two mines, Longyan and Taochong, in China. The cohort was limited to men and consisted of 5406 underground miners and 1038 unexposed surface workers. Among the 490 underground miners who died, 205 (42%) died of silicosis and silicotuberculosis and 98 (20%) of cancer, including 29 cases (5.9%) of lung cancer. The study found an excess risk of non-malignant respiratory disease and of lung cancer among haematite miners. The standardised mortality ratio for lung cancer compared with nationwide male population rates was significantly raised (SMR = 3.7), especially for those miners who were first employed underground before mechanical ventilation and wet drilling were introduced (SMR = 4.8); with jobs involving heavy exposure to dust, radon, and radon daughters (SMR = 4.2); with a history of silicosis (SMR = 5.3); and with silicotuberculosis (SMR = 6.6). No excess risk of lung cancer was observed in unexposed workers (SMR = 1.2). Among current smokers, the risk of lung cancer increased with the level of exposure to dust. The mortality from all cancer, stomach, liver, and oesophageal cancer was not raised among underground miners. An excess risk of lung cancer among underground mine workers which could not be attributed solely to tobacco use was associated with working conditions underground, especially with exposure to dust and radon gas and with the presence of non-malignant respiratory disease. Because of an overlap of exposures to dust and radon daughters, the independent effects of these factors could not be evaluated.  (+info)

Mortality of workers compensated for silicosis during the period 1959-1963 in the Veneto region of Italy. (8/12)

After reports appeared from other countries indicating an excess risk of lung cancer among silicotics, a cohort of workers compensated for silicosis during the period 1959-1963 in the Veneto region of Italy was constructed and followed for mortality through 1984. The results of the study showed a large mortality excess for infectious diseases (180 observed versus 9.5 expected), due to silicotuberculosis, and for diseases of the respiratory system (270 observed versus 33.5 expected) due to silicosis. An elevated standardized mortality ratio of 239 (70 observed versus 29.3 expected) from lung cancer was also detected. An increasing pattern was observed with time since first exposure, while the relationship with employment category and duration of exposure was less clear-cut. The lung cancer excess was also strongly associated with cigarette smoking, there being a dose-response relationship with daily cigarette consumption. The study confirms the results from other epidemiologic studies on silicotics which show this pathological condition to be associated with increased lung cancer mortality.  (+info)

Silicotuberculosis is not a medical condition that has its own specific definition in the medical literature. However, the term is sometimes used to describe a situation where a patient has both silicosis (a lung disease caused by inhaling crystalline silica dust) and tuberculosis (a bacterial infection that primarily affects the lungs).

Silicosis can increase a person's risk of developing tuberculosis, as the scarring and inflammation caused by silicosis can make the lungs more susceptible to infection. In some cases, the presence of silicosis may also affect the diagnosis and treatment of tuberculosis. Therefore, it is important for healthcare providers to be aware of any history of silica exposure when evaluating a patient with lung symptoms or signs of tuberculosis.

A case of combined rheumatic heart disease, syphilitic aortitis, and silico-tuberculosis. Wis Med J. 1974 Jan; 73(1): S3-6. ...
"Silicosis and Silicotuberculosis"), which earned him the State Prize for 1952. He also worked alongside Aurel Moga in ...
... silicotuberculosis, and tetanus. Exposures from certain construction activities have been associated with an increased risk of ...
... silicotuberculosis MeSH C01.252.410.040.552.846.922 - tuberculosis, splenic MeSH C01.252.410.040.552.846.944 - tuberculosis, ...
... silicotuberculosis MeSH C08.785.520.140 - carcinoma, bronchogenic MeSH C08.785.520.145 - carcinoma, non-small-cell lung MeSH ... silicotuberculosis MeSH C08.460.669.693 - paranasal sinus neoplasms MeSH C08.460.669.693.575 - maxillary sinus neoplasms MeSH ... silicotuberculosis MeSH C08.381.483.620 - pulmonary fibrosis MeSH C08.381.483.675 - radiation pneumonitis MeSH C08.381.483.725 ...
... silico-tuberculosis and talcosis. It also has jurisdiction over any other pathological condition of the lungs, pleura or ...
... infection-known as silicotuberculosis. The reason for the increased risk-3 fold increased incidence-is not well understood. It ...
... silicotuberculosis MeSH C21.613.127.141 - arachnidism MeSH C21.613.127.441 - insect bites and stings MeSH C21.613.127.722 - ...
Silicotuberculosis *Colliers phthisis. *Grinders phthisis. *Miners phthisis. *Stonemasons phthisis. 010 No discrete ICD-9 ...
Mini-review: Silico-tuberculosis. Lanzafame M, Vento S. Lanzafame M, et al. J Clin Tuberc Other Mycobact Dis. 2021 Feb 2;23: ...
SENSOR had been informed of the death of a sandblasting worker due to silico tuberculosis; the worker had been employed at the ... Silico-Tuberculosis; Respirable Quartz; Medical Screening; Mycobacteria; Chest X-ray; Sandblasting ...
A case of combined rheumatic heart disease, syphilitic aortitis, and silico-tuberculosis. Wis Med J. 1974 Jan; 73(1): S3-6. ...
Ogawa S, Imai H, Ikeda M. Mortality due to silico-tuberculosis and lung cancer among 200 whetstonecutters. Ind Health. 2003 Jul ...
Silicotuberculosis resembles conglomerate silicosis on x-rays. The distinction can be made by sputum culture. 7-Treatment : No ... A frequent cause of death in people with silicosis is pulmonary tuberculosis (silico-tuberculosis). Respiratory insufficiencies ... silico-tuberculosis) has carried off to a premature death ". Only a few years ago certain villages in Northern Thailand were ...
Antimerger, her protostelic lichenified quasi-contrarily conceptualizing he arrogant pro nobody silicotuberculosis. ... her protostelic lichenified quasi-contrarily conceptualizing he arrogant pro nobody silicotuberculosis. Portends crinkle ...
... treatment of culture-positive silicotuberculosis requires that the usual therapy be extended by at least 2 mo (47). The latter ... clinical comparison of 6 and 8 months of antituberculosis chemotherapy in the treatment of patients with silicotuberculosis in ...
SILICOTUBERCULOSIS IN RATS NTC 76-12399-06E KINOSHITA, F. //KAKU IGAKU (NIHON KAKU,.filGAKKAI KIKANSHII// 00/00/1974,VO011,N ...
... or silicotuberculosis, arising out of such employment. . . .". Under 20 C.F.R. § 410.401(b)-(2) pneumoconiosis is also defined ...
One of the most common occupational diseases among people who cut and polish stones are silicosis and silicotuberculosis. ...
Immunopathogenesis of Silicotuberculosis: A Literature Review Indi Esha, Elvando Tunggul Mauliate Simatupang ...
Silicotuberculosis,. *Manganism,. *Acute myelogenous leukemia,. *Myelodysplastic syndrome,. *Injuries caused by repetitive ...
silicotuberculosis. *. talcosis; or. *. any other pathological condition of the lungs, pleura or peritoneum that is ...
Silico-tuberculosis. Systemic sclerosis. Talcosis. sch 1 (previously Sch): Ins 1967 No 98, sec 3 (1) (m). Am 1983 No 208, Sch 1 ...
CXR: Silico-Tuberculosis. Stanley Medical College, Department of Medicine•4K. views. ECG: A Case of Flutter-Fibrillation. ...
Mini-review: Silico-tuberculosis. J Clin Tuberc Other Mycobact Dis 2021; 23:100218. doi: 10.1016/j.jctube.2021.100218. PMID: ...
Inclusion of silicotuberculosis images reduced each systems ability to detect either disease. In differentiating between any ... silicotuberculosis 25.7%, and current active tuberculosis 6.8%. Of those with tuberculosis diagnosed microbiologically, 6.7% ...
Patients with silicosis are particularly susceptible to tuberculosis TB infection-known as silicotuberculosis. The French ...
Silicotuberculosis, Siderosis, Bronchopulmonary diseases, Asthma, Extrinsic allergic alveolitis are some of the other ...
The Promise and Potential Consequences of Screening Tests for Early Detection of Silicosis and Silico-tuberculosis. Workers are ...
Potential consequences of screening of occupational silica dust exposed workers for early detection of silicosis/silico-tuberculosis ...
... a productive trip to Kibongoto Hospital in Tanzania last week where they met with collaborators to discuss silicotuberculosis ...
Although silicosis, tuberculosis (TB) and the comorbid condition of silicotuberculosis are diseases of antiquity, accurate and ...
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i) Silicosis (Silico-tuberculosis) occurs due to inhalation of free silica, or SiO2 (Silicon dioxide), while mining or working ...
... silicotuberculosis 25.7%, and current active tuberculosis 6.8%. Of those with tuberculosis diagnosed microbiologically, 6.7% ...
Some parameters of nonspecific resistance of the body in patients with silicosis and silico tuberculosis. Gigiena Truda i ...
Occupational diseases such as Pneumoconioses caused by Sclerogenic mineral dust and Silico-tuberculosis, Bagassosis, ...
  • A chronic dust disease of the lung arising out of employment in the Nation's coal mines, and includes coal workers' pneumoconiosis, anthracosilicosis, anthracosis, anthrosilicosis, massive pulmonary fibrosis, progressive massive fibrosis, silicosis, or silicotuberculosis, arising out of such employment. (justia.com)
  • Infección pulmonar o extrapulmonar causada por MYCOBACTERIUM TUBERCULOSIS o por micobacterias no tuberculosas en pacientes con silicosis. (bvsalud.org)