Sister Mary Joseph's Nodule
Umbilicus
Hernia, Umbilical
"Sister Mary Joseph's nodule" is a term used in medicine to describe a palpable (able to be felt) or visible nodule or lump that is located at the umbilicus (belly button). It is usually indicative of an underlying malignancy, most commonly originating from the stomach or ovaries. The presence of this nodule suggests a poor prognosis as it often indicates advanced stage cancer. The term was coined by Dr. Hamilton Bailey in honor of Sister Mary Joseph, who first recognized the association between umbilical nodules and internal malignancies during her work as a surgical nurse with Dr. William Mayo in the early 20th century.
The umbilicus, also known as the navel, is the scar left on the abdominal wall after the removal of the umbilical cord in a newborn. The umbilical cord connects the developing fetus to the placenta in the uterus during pregnancy, providing essential nutrients and oxygen while removing waste products. After birth, the cord is clamped and cut, leaving behind a small stump that eventually dries up and falls off, leaving the umbilicus. In adults, it typically appears as a slight depression or dimple on the abdomen.
An umbilical hernia is a type of hernia that occurs at the umbilicus, or belly button. It results from a protrusion of abdominal contents through a weakened area in the abdominal wall surrounding the navel. This condition is common in newborns and infants, especially premature babies, due to incomplete closure of the abdominal muscles during development.
In most cases, umbilical hernias in children close on their own by age 3-4 or by the time they reach school age. However, if the hernia is still present after this age, surgical intervention may be required to prevent potential complications such as incarceration (where the herniated tissue becomes trapped and cannot be pushed back in) or strangulation (where the blood supply to the herniated tissue is cut off, leading to tissue death).
Adults can also develop umbilical hernias, often as a result of increased pressure in the abdomen due to obesity, pregnancy, heavy lifting, or persistent coughing. Umbilical hernias in adults are generally more likely to require surgical repair due to the higher risk of complications.
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Sister Mary Joseph nodule - Wikipedia
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Joseph's Nodule12
- Yendluri V, Centeno B, Springett G. Pancreatic cancer presenting as a Sister Mary Joseph's nodule: case report and update of the literature. (wikipedia.org)
- Sister Mary Joseph's nodule. (wikipedia.org)
- Touraud JP, Lentz N, Dutronc Y, Mercier E, Sagot P, Lambert D. Umbilical cutaneous metastasis (or Sister Mary Joseph's nodule) disclosing an ovarian adenocarcinoma Gynecol Obstet Fertil. (edu.pk)
- Metastatic nodules of the umbilicus from malignant neoplasms are known as Sister Mary Joseph's nodule and they represent an advanced malignancy. (irispublishers.com)
- Sister Mary Joseph's Nodule is the name given to the malignant metastatic deposits of the umbilicus. (irispublishers.com)
- The term "Sister Mary Joseph's Nodule was coined by Sir Hamilton Bailey in his book, Physical Signs in Clinical Surgery, in the honor of Sister Mary Joseph who was a surgical assistant of Dr. William Mayo in the early days of the Mayo Clinic. (irispublishers.com)
- A Case of Sister Mary Joseph's Nodule after Radiation Therapy for Cervical Cancer]. (bvsalud.org)
- An umbilical metastasis from an internal malignancy is called Sister Mary Joseph's nodule (SMJN)and has a poor prognosis . (bvsalud.org)
- Sister Joseph's nodule is a lymphatic metastasis to the umbilical region. (aafp.org)
- Sister Joseph (1856-1939), superintendent of St. Mary's Hospital, was credited with making the observation of lymphatic metastases to the umbilical region in metastatic tumors of intra-abdominal origin, hence the name "Sister Joseph's nodule. (aafp.org)
- 1 Indeed, the primary tumor in most cases of Sister Joseph's nodule is intra-abdominal: stomach, large and small intestine, pancreas, kidney, uterus, ovary or gallbladder. (aafp.org)
- 2 , 4 In summary, Sister Joseph's nodule is a rare but important clinical finding. (aafp.org)
Pancreatic1
- Sister Mary Joseph nodule associated with pancreatic adenocarcinoma. (edu.pk)
Metastases1
- Sister Mary Joseph nodule is associated with multiple peritoneal metastases and a poor prognosis. (wikipedia.org)
Metastasis3
- In medicine, the Sister Mary Joseph nodule (sometimes Sister Mary Joseph node or Sister Mary Joseph sign) refers to a palpable nodule bulging into the umbilicus as a result of metastasis of a malignant cancer in the pelvis or abdomen. (wikipedia.org)
- Palaniappan M, Jose WM, Mehta A, Kumar K, Pavithran K. Umbilical metastasis: a case series of four Sister Joseph nodules from four different visceral malignancies Curr Oncol 2010;17(6):78-81. (edu.pk)
- Although generally a poor prognostic sign, long-term survival may be possible if the nodule represents a solitary metastasis. (aafp.org)
Metastatic5
- Metastatic cancer of the umbilicus, known as Sister Mary Joseph nodule, is typically associated with visceral malignancy. (edu.pk)
- Here, we describe case of a patient with squamous cell carcinoma of lung who presented with metastatic umbilical nodule as the initial presentation of the tumor. (irispublishers.com)
- Metastatic umbilical nodules from lung carcinoma and that too from squamous cell carcinoma are very rare. (irispublishers.com)
- Patients presenting with umbilical nodules should be investigated without any delay and metastatic nodule should be included in the differential diagnosis especially in elderly patients. (irispublishers.com)
- Additionally, the CT scan revealed two hypodense areas in the liver and a 15-mm nodule in the lower lobe of the right lung, suspicious for metastatic disease. (aafp.org)
Malignancy1
- Sister Mary Joseph was the one who identified the relationship between umbilical nodules and advanced intraabdominal malignancy. (irispublishers.com)
Differential diagnosis1
- Whenever a patient presents to the clinician with umbilical nodule the differential diagnosis includes both benign and malignant conditions. (irispublishers.com)
Hypodense1
- Abdominal CT showed a left hypodense hepatic nodule. (bmj.com)
Umbilicus1
- An 84-year-old woman presented for evaluation of various benign skin lesions and was incidentally noted to have an 8-mm violaceous nodule in the umbilicus ( Figure 1 ) . (aafp.org)
Umbilical region1
- We present a case of 56 years old male patient who came to the surgery clinic of our hospital with complains of a recently noticed nodule in the umbilical region. (irispublishers.com)
Hamilton Bailey1
- The eponymous term Sister Mary Joseph nodule was coined in 1949 by Hamilton Bailey. (wikipedia.org)
Benign1
- This patient had a benign non-functioning thyroid nodule. (stanford.edu)
Abdominal2
- Medical imaging, such as abdominal ultrasound, may be used to distinguish a Sister Mary Joseph nodule from another kind of mass. (wikipedia.org)
- A 66-year-old diabetic woman was admitted for an abdominal nodule that had been evolving for 6 months. (bmj.com)
Presenting1
- Sister Mary joseph nodule as a presenting sign of pancreatobiliary adenocarcinoma. (edu.pk)
Primary1
- These nodules are mostly adenocarcinomas with the commonest primary sites in intraabdominal organs. (irispublishers.com)
Mayo Clinic1
- The author, Siva Subramaniam, M.B.B.S., interviewed various persons at Mayo Clinic and also Sister Marisa McDonald in our Archives office. (rochesterfranciscan.org)
Case1
- Sister Mary Joseph nodule-A case report with review of literature. (edu.pk)
Clinical1
- Clinical examination found an isolated umbilical nodule of 3.5 cm without any other symptoms or signs (figure 1A). (bmj.com)
Found2
- The general management of a thyroid nodule, either found on exam or imaging (if non-palpable) is to measure the serum TSH level. (stanford.edu)
- Joseph Barnett says that he "always found her of sober habits. (casebook.org)
Patient1
- After cytological reporting of the umbilical nodule the patient was further investigated. (irispublishers.com)
Initial1
- However, if the radionuclide study shows a non-functioning thyroid nodule or if the initial TSH level is normal or elevated, all patients should receive a thyroid fine needle aspiration to rule out cancer. (stanford.edu)
Important1
- Thyroid nodules are important not to miss on exam as the major concern is to rule out a thyroid cancer. (stanford.edu)
Small1
- Although she had annual mammograms with no significant discoveries, Eileen's MRI was able to spot a small nodule that otherwise may have gone unnoticed for years. (providence.org)
Cancer2
- Nodules will also, rarely, originate from appendix cancer spillage and pseudomyxoma peritonei. (wikipedia.org)
- Her biopsy showed Stage 1 breast cancer with a two-centimeter nodule. (providence.org)
Hospital3
- Sister Mary Joseph Dempsey (born Julia Dempsey) was a Catholic nun and surgical assistant of William J. Mayo at St. Mary's Hospital in Rochester, Minnesota from 1890 to 1915. (wikipedia.org)
- Due to visitor restrictions for COVID-19, the sisters weren't allowed to have any family visit in the hospital, however caregivers at St. Peter Hospital arranged for the two sisters to recover together. (providence.org)
- Mary Newport, MD, has been medical director of the neonatal intensive care unit at Spring Hill Regional Hospital in Florida since it opened in 2003. (anh-usa.org)
Area1
- Those that occur in the umbilical area are called Sister Mary Joseph's nodules. (journalmc.org)
Mass1
- A periumbilical mass is not always a Sister Mary Joseph nodule. (wikipedia.org)
Skin1
- Overlying skin was erythematous and adherent to the nodule. (irispublishers.com)
Article1
- Although online access to view the article is not available without a subscription, Sister Marisa has a copy in the Archives, should you wish to read it. (rochesterfranciscan.org)
Kelly2
- Mary Jane Kelly was approximately 25 years old at the time of her death which would place her birth around 1863. (casebook.org)
- According to Joseph Barnett, on arriving in London, Kelly went to work in a high class brothel in the West End. (casebook.org)
Report1
- Sister Joan Brown was interviewed by Global Sisters Report for the December 28, 2021 issue. (rochesterfranciscan.org)
Woman1
- Joseph Barnett and Mrs. Carthy , a woman with whom she lived at one time, say that she came from a family that was "fairly well off" (Barnett) and "well to do people" (Carthy). (casebook.org)
Brothers1
- Mary Jane claims to have 6 or 7 brothers and one sister. (casebook.org)