Dermatologic disorders attendant upon non-dermatologic disease or injury.
'Skin diseases' is a broad term for various conditions affecting the skin, including inflammatory disorders, infections, benign and malignant tumors, congenital abnormalities, and degenerative diseases, which can cause symptoms such as rashes, discoloration, eruptions, lesions, itching, or pain.
An erythematous eruption commonly associated with drug reactions or infection and characterized by inflammatory nodules that are usually tender, multiple, and bilateral. These nodules are located predominantly on the shins with less common occurrence on the thighs and forearms. They undergo characteristic color changes ending in temporary bruise-like areas. This condition usually subsides in 3-6 weeks without scarring or atrophy.
A form of lupus erythematosus in which the skin may be the only organ involved or in which skin involvement precedes the spread into other body systems. It has been classified into three forms - acute (= LUPUS ERYTHEMATOSUS, SYSTEMIC with skin lesions), subacute, and chronic (= LUPUS ERYTHEMATOSUS, DISCOID).
Inflammation involving the skin of the extremities, especially the hands and feet. Several forms are known, some idiopathic and some hereditary. The infantile form is called Gianotti-Crosti syndrome.
Adverse cutaneous reactions caused by ingestion, parenteral use, or local application of a drug. These may assume various morphologic patterns and produce various types of lesions.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
The process of aging due to changes in the structure and elasticity of the skin over time. It may be a part of physiological aging or it may be due to the effects of ultraviolet radiation, usually through exposure to sunlight.
Tumors or cancer of the SKIN.
Epicutaneous or intradermal application of a sensitizer for demonstration of either delayed or immediate hypersensitivity. Used in diagnosis of hypersensitivity or as a test for cellular immunity.
The functions of the skin in the human and animal body. It includes the pigmentation of the skin.
Uptake of substances through the SKIN.
Coloration of the skin.
Synthetic material used for the treatment of burns and other conditions involving large-scale loss of skin. It often consists of an outer (epidermal) layer of silicone and an inner (dermal) layer of collagen and chondroitin 6-sulfate. The dermal layer elicits new growth and vascular invasion and the outer layer is later removed and replaced by a graft.
A skin ulcer is a breakdown of the skin's surface and underlying tissues, often caused by prolonged pressure, infection, or poor circulation, leading to a loss of continuity in the epidermis and dermis, potentially extending into deeper layers such as subcutaneous tissue, muscle, and bone.
Skin diseases caused by bacteria.
The external, nonvascular layer of the skin. It is made up, from within outward, of five layers of EPITHELIUM: (1) basal layer (stratum basale epidermidis); (2) spinous layer (stratum spinosum epidermidis); (3) granular layer (stratum granulosum epidermidis); (4) clear layer (stratum lucidum epidermidis); and (5) horny layer (stratum corneum epidermidis).

Sarcoidosis of the upper respiratory tract and its association with lupus pernio. (1/32)

In a series of 34 patients with sarcoidosis affecting the upper respiratory tract and nose, 26 had lupus pernio (LP) and 17 had sarcoidosis of the upper respiratory tract (SURT). In nine patients these features coexisted. A patient presenting with SURT carried a 50% risk of developing LP although one feature could be present without the other. Both were disorders of women of the child-bearing years of life. SURT, like LP, was an indicator of chronic fibrotic sarcoidosis, developing insidiously and progressing indolently over the years. It was complicated by ulceration, septal perforation, and LP. Three patients had nasal septal perforations, in two instances following submucous resection. This operation is contraindicated in patients with active sarcoidosis, particularly when granulomas are found on nasal biopsy. The Kveim-Siltzbach skin test was positive in all patients with SURT, making it invaluable in the differential diagnosis of granuloma of the nasal cavity.  (+info)

Pure red cell aplasia (PRCA): Response of three patients of cyclophosphamide and/or antilymphocyte globulin (ALG) and demonstration of two types of serum IgG inhibitors to erythropoiesis. (2/32)

Three cases of adult pure red cell aplasia (PRCA) ARE REPORTED. All patients proved refractory to various combinations of androgens and corticosteroids. The first case, harboring a thymoma, showed a complete clinical remission following cyclophosphamide therapy. The second and third responded similarly to either a combined cyclophosphamide + antilymphocyte globulin (ALG) treatment or to ALG administration preceded by a small dosage of cyclophosphamide, which had proved ineffective when administered alone. Serum IgG inhibitors to erythropoiesis were demonstrated in all cases by means of in vivo and/or in vitro techniques. The inhibitor(s), although directed against the erythroid marrow in both the first and third patients (PRCA type A), apparently functioned as an antibody to circulating erythropoientin (Ep) in the second case (PRCA type B). The inhibitor(s) was always absent in postremission samples. Additionally, experimental models for both types of human PRCA were established in normal rodents. The present studies support the contention that adult PRCA is an autoimmune disease. The therapeutic role of cytotoxic-immunodepressive agents in PRCA patients is confirmed. It is emphasized that ALG may represent an additional therapeutic tool in cases resistant to cyclophosphamide and/or steroids. In addition, cyclophosphamide proved effective in a patient harboring a thymoma not amenable to surgery. Finally, it is postulated that IgG serum autoantibodies, directed against either an early erythroid precursor (PRCA type A) or, more rarely, circulating Ep (PRCA type B), play a major role in the pathogenesis of the disease.  (+info)

Letter: Order contraceptives and the liver.(3/32)

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Chromosomal synthesis of staphylococcal exfoliative toxin. (4/32)

Tox-+ staphylococcal strains, as opposed to Tox-minus strains, produce epidermal exfoliation within 18 h after direct subcutaneous or intraperitoneal injection into newborn mice. The extracellular product responsible for exfoliation is termed exfoliative toxin (ET). When culture supernatant fluid from the plasmid-cured Tox-minus substrains UT 0100 or UT 0111 or from six naturally occurring phage group 2 Tox-minus strains was concentrated 20-fold and inoculated into newborn mice, ET activity could be detected. The Tox-minus, cured derivatives produced ET at levels which were 32 minus and 64-fold lower than the amounts made by their Tox-+ parent strains. Since these Tox-minus, cured substrains contained no plasmid deoxyribonucleic acid, it was postulated that the product possessing ET activity in strains UT 0100 and UT 0111 was made by chromosomal genes. This product has been isolated and purified from strain UT 0100 and appears as two faint bands after electrophoresis on polyacrylamide gels and corresponds in position to a heavy band of ET isolated from the Tox-+ strain UT 0007.  (+info)

The Gardner syndrome: increased tetraploidy in cultured skin fibroblast. (5/32)

Tetraploidy was increased in skin fibroblast cultures grown in the laboratory at the same time under the same conditions and derived from 2 probands with the Gardner syndrome and 9 affected members of one family as compared to that occurring in cultures from 5 relatives by marriage and 10 normals. Tetraploidy was present at the first subculture (2 weeks after the initial biopsy was cultured), and for each line studied the percentage of dividing cells showing tetraploidy remained constant. The relation of the observed tetraploidy to the increased risk of such patients to develop abnormal growths and cancer has not been established. The increased tetraploidy should be of value in identifying the presence of the gene for the Gardner syndrome in high risk families.  (+info)

PIGMENT DEPOSITION IN VISCERA ASSOCIATED WITH PROLONGED CHLORPROMAZINE THERAPY. (6/32)

Twelve physically healthy young adult mental hospital patients died unexpectedly while on prolonged chlorpromazine therapy. Five of them had clinically obvious pigmentation of the exposed skin. Two of these had impairment of vision as well. Autopsies were performed on all 12 patients. Extensive deposits of pigment (exhibiting the physical and histochemical properties of melanin) were present in macrophages in the dermis and throughout the reticuloendothelial system, and in the parenchymal cells of internal organs. The dopa tyrosinase reaction indicated increased melanocyte activity in the epidermis.The possible mechanism of production of this pigment is discussed, and the belief is expressed that the increased melanin production is due, at least partly, to the effect of chlorpromazine on the autonomic nervous system, blocking the production of pigment-lightening factors, of which melatonin is the most important. A short outline of contemplated further investigation is given.  (+info)

SYSTEMIC EFFECTS OF NON-ENDOCRINE TUMOURS. (7/32)

Tumours of non-endocrine origin may exert deleterious effects by elaborating active principles which disturb body regulation. Systemic manifestations are fairly common with neoplasms of the lung, kidney, gastro-intestinal tract and thymus. The secretion of these tumours may have a known chemical structure (serotonin), may present hormone-like action (parathormone, antidiuretic hormone, insulinoid), or have well-defined biological properties (erythropoietin, gastrin-like principle). Tumours may stimulate endocrine glands by an unknown mechanism, producing disorders such as Cushing's syndrome, hypercalcemia, gynecomastia and hypoglycemia. Thymomas may be associated with autoimmune diseases. Tumours may extensively utilize or excrete some metabolite (glucose) or electrolyte (Na or K). Awareness of the systemic effects of various neoplasms may lead to an early diagnosis and proper treatment of these manifestations.  (+info)

Chronic cutaneous graft-versus-host disease in man. (8/32)

This clinicopathologic study of patients with chronic graft-versus-host disease (GVHD) after allogeneic marrow transplantation emphasizes the most prominent feature of the syndrome, the cutaneous aspects, and describes the ophthalmic-oral sicca syndrome with sialoadenitis and the neurologic findings. Chronic cutaneous GVHD affected 19 of 92 recipients surviving 150 days or more. In 6 patients chronic GVHD presented as a continuation of acute GVHD; in 8 it occurred after the resolution of acute GVHD; and in 5 it arose without preceding acute GVHD, ie, de novo late onset. Two cutaneous types were distinguished. The generalized type affected 16 patients and ran a progressive course resulting in late complications of poikiloderma, diffuse dermal and subcutaneous fibrosis, and contractures. Microscopically, it resembled generalized morphea and lupus erythermatosus hypertrophicus et profundus. The local type affected 3 patients with a more variable picture of poikiloderma, dermal sclerosis, and contractures. Microscopically, it resembled lupus of erythematosus profundus and scleroderma. Guidelines for defining and subclassifying chronic cutaneous GVHD are proposed.  (+info)

Skin manifestations refer to visible changes on the skin that can indicate an underlying medical condition or disease process. These changes can include rashes, lesions, discoloration, eruptions, blisters, hives, and other abnormalities. The appearance, distribution, and pattern of these manifestations can provide important clues for healthcare professionals to diagnose and manage the underlying condition.

Skin manifestations can be caused by a wide range of factors, including infections, inflammatory conditions, allergic reactions, genetic disorders, autoimmune diseases, and cancer. In some cases, skin manifestations may be the primary symptom of a medical condition, while in other cases, they may be a secondary effect of medication or treatment.

It is important to note that while skin manifestations can provide valuable diagnostic information, they should always be evaluated in the context of the patient's overall medical history and presentation. A thorough physical examination and appropriate diagnostic tests are often necessary to confirm a diagnosis and develop an effective treatment plan.

Skin diseases, also known as dermatological conditions, refer to any medical condition that affects the skin, which is the largest organ of the human body. These diseases can affect the skin's function, appearance, or overall health. They can be caused by various factors, including genetics, infections, allergies, environmental factors, and aging.

Skin diseases can present in many different forms, such as rashes, blisters, sores, discolorations, growths, or changes in texture. Some common examples of skin diseases include acne, eczema, psoriasis, dermatitis, fungal infections, viral infections, bacterial infections, and skin cancer.

The symptoms and severity of skin diseases can vary widely depending on the specific condition and individual factors. Some skin diseases are mild and can be treated with over-the-counter medications or topical creams, while others may require more intensive treatments such as prescription medications, light therapy, or even surgery.

It is important to seek medical attention if you experience any unusual or persistent changes in your skin, as some skin diseases can be serious or indicative of other underlying health conditions. A dermatologist is a medical doctor who specializes in the diagnosis and treatment of skin diseases.

Erythema nodosum is a type of inflammation that occurs in the fatty layer of the skin, causing painful, red or purple bumps (nodules) to form. It is a type of panniculitis, which refers to any condition that causes inflammation of the fatty layer of tissue beneath the skin.

Erythema nodosum is often associated with a variety of underlying conditions, such as infections (e.g., streptococcus, tuberculosis), medications (e.g., sulfa drugs, oral contraceptives), inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis), and pregnancy.

The bumps associated with erythema nodosum typically appear on the shins, ankles, knees, or other areas of the legs, although they can also occur on the arms, hands, or face. The bumps may be tender to the touch, warm, and swollen, and they may cause pain or discomfort when walking or standing for prolonged periods.

In most cases, erythema nodosum resolves on its own within a few weeks to several months, although symptoms can be managed with medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids. Treating the underlying condition is also important for resolving erythema nodosum and preventing recurrences.

Cutaneous Lupus Erythematosus (CLE) is a skin manifestation of Systemic Lupus Erythematosus (SLE), an autoimmune disease, but it can also occur without systemic involvement. It is characterized by various skin lesions that differ in appearance and distribution. The three main subtypes of CLE are:

1. Acute Cutaneous Lupus Erythematosus (ACLE): This form is typically associated with SLE and is characterized by a classic malar or "butterfly" rash on the face, which is often photosensitive and can be accompanied by discoid lesions. The rash may also appear on other sun-exposed areas of the body.

2. Chronic Cutaneous Lupus Erythematosus (CCLE): This subtype includes Discoid Lupus Erythematosus (DLE) and other less common forms such as lupus panniculitis and chilblain lupus. DLE is characterized by well-circumscribed, erythematous, scaly plaques that can cause scarring and pigmentation changes, often found on the face, scalp, and ears. Lupus panniculitis presents as deep subcutaneous nodules or indurated plaques, typically located on the trunk and proximal extremities. Chilblain lupus is characterized by violaceous, tender, and swollen lesions on acral areas, often triggered by cold exposure.

3. Subacute Cutaneous Lupus Erythematosus (SCLE): This form of CLE presents as non-scarring, papulosquamous or annular polycyclic rashes, often located on the trunk and proximal extremities. The lesions are typically photosensitive and may appear in patients with SLE or those with isolated cutaneous disease.

The diagnosis of Cutaneous Lupus Erythematosus is based on clinical presentation, histopathological findings, and sometimes direct immunofluorescence. Treatment depends on the severity and extent of skin involvement and may include topical therapies, antimalarials, corticosteroids, immunomodulatory agents, or photoprotection measures.

Acrodermatitis is a term that describes several inflammatory skin conditions characterized by redness, swelling, and blistering that typically affect the hands, feet, and face. The medical definition of acrodermatitis includes various subtypes, each with its own specific causes and symptoms. Here are some of the most common forms of acrodermatitis:

1. Acrodermatitis enteropathica: A rare inherited disorder caused by a deficiency in zinc absorption. Symptoms include redness, swelling, blistering, and crusting around the mouth, eyes, and genitals, as well as the hands and feet.
2. Acrodermatitis continua of Hallopeau: A rare chronic inflammatory skin condition that affects the fingertips and toes. Symptoms include redness, swelling, blistering, and crusting, which can lead to nail deformities and loss.
3. Gianotti-Crosti syndrome (acrodermatitis papulosa): A viral exanthem that typically affects children between 6 months and 15 years of age. Symptoms include red, raised bumps on the face, buttocks, and extremities, which can be itchy and painful.
4. Pustular acrodermatitis: A rare skin condition characterized by pustules (pus-filled bumps) that form on the palms of the hands and soles of the feet. Symptoms may also include fever, chills, and fatigue.
5. Infantile acrodermatitis: A rare inflammatory skin disorder that affects infants and young children. Symptoms include redness, swelling, and blistering around the mouth, eyes, and genitals, as well as the hands and feet.

Treatment for acrodermatitis depends on the underlying cause of the condition. In some cases, topical creams or ointments may be sufficient to manage symptoms, while in others, systemic treatments such as antibiotics or immunosuppressive drugs may be necessary.

A "drug eruption" is a general term used to describe an adverse skin reaction that occurs as a result of taking a medication. These reactions can vary in severity and appearance, and may include symptoms such as rash, hives, itching, redness, blistering, or peeling of the skin. In some cases, drug eruptions can also cause systemic symptoms such as fever, fatigue, or joint pain.

The exact mechanism by which drugs cause eruptions is not fully understood, but it is thought to involve an abnormal immune response to the medication. There are many different types of drug eruptions, including morphilliform rashes, urticaria (hives), fixed drug eruptions, and Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), which is a severe and potentially life-threatening reaction.

If you suspect that you are experiencing a drug eruption, it is important to seek medical attention promptly. Your healthcare provider can help determine the cause of the reaction and recommend appropriate treatment. In some cases, it may be necessary to discontinue the medication causing the reaction and switch to an alternative therapy.

In medical terms, the skin is the largest organ of the human body. It consists of two main layers: the epidermis (outer layer) and dermis (inner layer), as well as accessory structures like hair follicles, sweat glands, and oil glands. The skin plays a crucial role in protecting us from external factors such as bacteria, viruses, and environmental hazards, while also regulating body temperature and enabling the sense of touch.

Skin aging, also known as cutaneous aging, is a complex and multifactorial process characterized by various visible changes in the skin's appearance and function. It can be divided into two main types: intrinsic (chronological or natural) aging and extrinsic (environmental) aging.

Intrinsic aging is a genetically determined and time-dependent process that results from internal factors such as cellular metabolism, hormonal changes, and genetic predisposition. The primary features of intrinsic aging include gradual thinning of the epidermis and dermis, decreased collagen and elastin production, reduced skin cell turnover, and impaired wound healing. Clinically, these changes present as fine wrinkles, dryness, loss of elasticity, and increased fragility of the skin.

Extrinsic aging, on the other hand, is caused by external factors such as ultraviolet (UV) radiation, pollution, smoking, alcohol consumption, and poor nutrition. Exposure to these environmental elements leads to oxidative stress, inflammation, and DNA damage, which accelerate the aging process. The main features of extrinsic aging are coarse wrinkles, pigmentary changes (e.g., age spots, melasma), irregular texture, skin laxity, and increased risk of developing skin cancers.

It is important to note that intrinsic and extrinsic aging processes often interact and contribute to the overall appearance of aged skin. A comprehensive approach to skincare should address both types of aging to maintain healthy and youthful-looking skin.

Skin neoplasms refer to abnormal growths or tumors in the skin that can be benign (non-cancerous) or malignant (cancerous). They result from uncontrolled multiplication of skin cells, which can form various types of lesions. These growths may appear as lumps, bumps, sores, patches, or discolored areas on the skin.

Benign skin neoplasms include conditions such as moles, warts, and seborrheic keratoses, while malignant skin neoplasms are primarily classified into melanoma, squamous cell carcinoma, and basal cell carcinoma. These three types of cancerous skin growths are collectively known as non-melanoma skin cancers (NMSCs). Melanoma is the most aggressive and dangerous form of skin cancer, while NMSCs tend to be less invasive but more common.

It's essential to monitor any changes in existing skin lesions or the appearance of new growths and consult a healthcare professional for proper evaluation and treatment if needed.

Skin tests are medical diagnostic procedures that involve the application of a small amount of a substance to the skin, usually through a scratch, prick, or injection, to determine if the body has an allergic reaction to it. The most common type of skin test is the patch test, which involves applying a patch containing a small amount of the suspected allergen to the skin and observing the area for signs of a reaction, such as redness, swelling, or itching, over a period of several days. Another type of skin test is the intradermal test, in which a small amount of the substance is injected just beneath the surface of the skin. Skin tests are used to help diagnose allergies, including those to pollen, mold, pets, and foods, as well as to identify sensitivities to medications, chemicals, and other substances.

"Skin physiological phenomena" is not a standard medical term with a specific definition. However, I can provide some information about the general concepts that might be encompassed by this term.

Physiological phenomena refer to the functions and processes that occur in living organisms. When it comes to the skin, there are many different physiological phenomena that take place, including:

1. Barrier function: The skin acts as a barrier to protect the body from external elements such as bacteria, viruses, chemicals, and UV radiation.
2. Temperature regulation: The skin helps regulate body temperature through sweat production and blood flow.
3. Sensation: The skin contains nerve endings that allow us to feel touch, pressure, pain, and temperature.
4. Vitamin D synthesis: The skin can produce vitamin D when exposed to sunlight.
5. Moisture regulation: The skin helps maintain the body's moisture balance by producing sweat and preventing water loss.
6. Immunological function: The skin plays a role in the immune system by providing a physical barrier and containing immune cells that help fight off infections.
7. Excretion: The skin eliminates waste products through sweat.
8. Wound healing: The skin has the ability to repair itself after injury, through a complex process involving inflammation, tissue regeneration, and remodeling.

Therefore, "skin physiological phenomena" could refer to any or all of these functions and processes that take place in the skin.

Skin absorption, also known as percutaneous absorption, refers to the process by which substances are taken up by the skin and pass into the systemic circulation. This occurs when a substance is applied topically to the skin and penetrates through the various layers of the epidermis and dermis until it reaches the capillaries, where it can be transported to other parts of the body.

The rate and extent of skin absorption depend on several factors, including the physicochemical properties of the substance (such as its molecular weight, lipophilicity, and charge), the concentration and formulation of the product, the site of application, and the integrity and condition of the skin.

Skin absorption is an important route of exposure for many chemicals, drugs, and cosmetic ingredients, and it can have both therapeutic and toxicological consequences. Therefore, understanding the mechanisms and factors that influence skin absorption is crucial for assessing the safety and efficacy of topical products and for developing strategies to enhance or reduce their absorption as needed.

Skin pigmentation is the coloration of the skin that is primarily determined by two types of melanin pigments, eumelanin and pheomelanin. These pigments are produced by melanocytes, which are specialized cells located in the epidermis. Eumelanin is responsible for brown or black coloration, while pheomelanin produces a red or yellow hue.

The amount and distribution of melanin in the skin can vary depending on genetic factors, age, sun exposure, and various other influences. Increased production of melanin in response to UV radiation from the sun helps protect the skin from damage, leading to darkening or tanning of the skin. However, excessive sun exposure can also cause irregular pigmentation, such as sunspots or freckles.

Abnormalities in skin pigmentation can result from various medical conditions, including albinism (lack of melanin production), vitiligo (loss of melanocytes leading to white patches), and melasma (excessive pigmentation often caused by hormonal changes). These conditions may require medical treatment to manage or improve the pigmentation issues.

Artificial Skin is a synthetic substitute or equivalent that is used to replace, support, or enhance the function of damaged or absent skin. It can be made from various materials such as biopolymers, composites, or biosynthetic materials. The main purpose of artificial skin is to provide a temporary or permanent covering for wounds, burns, or ulcers that cannot be healed with conventional treatments. Additionally, it may serve as a platform for the delivery of medications or as a matrix for the growth of cells and tissues during skin grafting procedures. Artificial skin must possess properties such as biocompatibility, durability, flexibility, and permeability to air and water vapor in order to promote optimal healing and minimize scarring.

A skin ulcer is a defined as a loss of continuity or disruption of the skin surface, often accompanied by inflammation and/or infection. These lesions can result from various causes including pressure, venous or arterial insufficiency, diabetes, and chronic dermatological conditions. Skin ulcers are typically characterized by their appearance, depth, location, and underlying cause. Common types of skin ulcers include pressure ulcers (also known as bedsores), venous leg ulcers, arterial ulcers, and diabetic foot ulcers. Proper evaluation, wound care, management of underlying conditions, and prevention strategies are crucial in the treatment of skin ulcers to promote healing and prevent complications.

Bacterial skin diseases are a type of infectious skin condition caused by various species of bacteria. These bacteria can multiply rapidly on the skin's surface when given the right conditions, leading to infection and inflammation. Some common bacterial skin diseases include:

1. Impetigo: A highly contagious superficial skin infection that typically affects exposed areas such as the face, hands, and feet. It is commonly caused by Staphylococcus aureus or Streptococcus pyogenes bacteria.
2. Cellulitis: A deep-skin infection that can spread rapidly and involves the inner layers of the skin and underlying tissue. It is often caused by Group A Streptococcus or Staphylococcus aureus bacteria.
3. Folliculitis: An inflammation of hair follicles, usually caused by an infection with Staphylococcus aureus or other bacteria.
4. Furuncles (boils) and carbuncles: Deep infections that develop from folliculitis when the infection spreads to surrounding tissue. A furuncle is a single boil, while a carbuncle is a cluster of boils.
5. Erysipelas: A superficial skin infection characterized by redness, swelling, and warmth in the affected area. It is typically caused by Group A Streptococcus bacteria.
6. MRSA (Methicillin-resistant Staphylococcus aureus) infections: Skin infections caused by a strain of Staphylococcus aureus that has developed resistance to many antibiotics, making it more difficult to treat.
7. Leptospirosis: A bacterial infection transmitted through contact with contaminated water or soil and characterized by flu-like symptoms and skin rashes.

Treatment for bacterial skin diseases usually involves the use of topical or oral antibiotics, depending on the severity and location of the infection. In some cases, drainage of pus-filled abscesses may be necessary to promote healing. Proper hygiene and wound care can help prevent the spread of these infections.

The epidermis is the outermost layer of the skin, composed mainly of stratified squamous epithelium. It forms a protective barrier that prevents water loss and inhibits the entry of microorganisms. The epidermis contains no blood vessels, and its cells are nourished by diffusion from the underlying dermis. The bottom-most layer of the epidermis, called the stratum basale, is responsible for generating new skin cells that eventually move up to replace dead cells on the surface. This process of cell turnover takes about 28 days in adults.

The most superficial part of the epidermis consists of dead cells called squames, which are constantly shed and replaced. The exact rate at which this happens varies depending on location; for example, it's faster on the palms and soles than elsewhere. Melanocytes, the pigment-producing cells, are also located in the epidermis, specifically within the stratum basale layer.

In summary, the epidermis is a vital part of our integumentary system, providing not only physical protection but also playing a crucial role in immunity and sensory perception through touch receptors called Pacinian corpuscles.

Sarcoidosis, an inflammatory disease, involves the skin in about 25% of patients. The most common lesions are erythema nodosum ... 2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0. Rapini, Ronald P.; Bolognia ... 710 Hypopigmented sarcoidosis is a cutaneous condition characterized by areas of hypopigmented skin. It is usually diagnosed in ... 710 Annular sarcoidosis is a cutaneous condition characterized by papular skin lesions arranged in annular patterns, usually ...
Genovese G, Moltrasio C, Berti E, Marzano AV (2021). "Skin Manifestations Associated with COVID-19: Current Knowledge and ... This type of skin rashes may be seen in cold-induced vasoconstriction as seen in polycythemia or other causes leading up to ... Cutaneous manifestations of COVID-19 are characteristic signs or symptoms of the Coronavirus disease 2019 that occur in the ... March 2021). "Maculopapular skin eruptions associated with Covid-19: A systematic review". review. Dermatologic Therapy. 34 (2 ...
Ermertcan AT, Ertan P (2010). "Skin manifestations of child abuse". Indian J Dermatol Venereol Leprol. 76 (4): 317-26. doi: ... Peeling skin syndrome (acral peeling skin syndrome, continual peeling skin syndrome, familial continual skin peeling, ... The two main types of human skin are: glabrous skin, the hairless skin on the palms and soles (also referred to as the " ... primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the skin, trabecular carcinoma of the skin) ...
"Skin Manifestations of Internal Disease". Harrison's Principles of Internal Medicine. New York, NY: McGraw-Hill. Cross, Harold ... Hypopigmentation is characterized specifically as an area of skin becoming lighter than the baseline skin color, but not ... As melanin pigments tend to be in the skin, eye, and hair, these are the commonly affected areas in those with hypopigmentation ... Hypopigmentation can be upsetting to some, especially those with darker skin whose hypopigmentation marks are seen more visibly ...
Mock DM (December 1991). "Skin manifestations of biotin deficiency". Semin Dermatol. 10 (4): 296-302. PMID 1764357. Möslinger D ... Patel, Deepa P.; Swink, Shane M.; Castelo-Soccio, Leslie (August 2017). "A Review of the Use of Biotin for Hair Loss". Skin ... Hoffman, Kristine (January 2015). "When Vitamin And Nutritional Deficiencies Cause Skin And Nail Changes". www. ...
"Skin manifestations of kidney disease". Parkhurst Exchange. Retrieved 2 October 2014. Falodun O, Ogunbiyi A, Salako B, George ... Uremic frost is a colloquial description for crystallized urea deposits that can be found on the skin of those affected by ... As water evaporates off the skin, it results in crystallization of the remaining urea.[citation needed] This condition is more ... Udayakumar P, Balasubramanian S, Ramalingam KS, Lakshmi C, Srinivas CR, Mathew AC (2006). "Cutaneous manifestations in patients ...
Stratakis, CA (September 2016). "Skin manifestations of Cushing's syndrome". Reviews in Endocrine & Metabolic Disorders. 17 (3 ... The blood flow is to the superficial capillaries of the skin. The increased blood flow causes swelling of the facial tissue ...
Young S, Fernandez AP (2020). "Skin manifestations of COVID-19". Cleveland Clinic Journal of Medicine. doi:10.3949/ccjm.87a. ... blanchable redness of the skin) Pain in affected area Skin discoloration, red to dark blue Chilblains caused by exposure to low ... Chilblains, also known as pernio, is a medical condition in which damage occurs to capillary beds in the skin, most often in ... Massey PR, Jones KM (May 2020). "Going viral: A brief history of chilblain-like skin lesions ("COVID toes") amidst the COVID-19 ...
Rashid M, Zarkadas M, Anca A, Limeback H (2011). "Oral manifestations of celiac disease: a clinical guide for dentists". J Can ... "Skin Lesions: Strawberry Tongue". Primary Care Dermatology Module (University of Wisconsin Madison). Retrieved 2007-08-14. ... Pastore L, Carroccio A, Compilato D, Panzarella V, Serpico R, Lo Muzio L (March 2008). "Oral manifestations of celiac disease ... Chi AC, Neville BW, Krayer JW, Gonsalves WC (December 2010). "Oral manifestations of systemic disease". Am Fam Physician ( ...
Signs include skin hyperpigmentation, alabaster-coloured pale skin, low blood pressure, postural hypotension. Skin pigmentation ... The manifestations depend on the affected area. The oral manifestations present as orofacial granulomatosis, an inflammatory ... Oral manifestations of systematic disease are signs and symptoms of disease occurring elsewhere in the body detected in the ... Eating disorder oral manifestation is severe palatal erosion due to vomiting. There is occlusal erosion of the maxillary teeth ...
Sadowska-Przytocka A, Czarnecka-Operacz M, Jenerowicz D, Grzybowski A (2016). "Ocular manifestations of infectious skin ... Fever, rash, skin sores, joint pain, swelling and stiffness are possible results. Increased risk of HIV/AIDS. Having gonorrhea ... If left untreated, gonorrhea can spread from the original site of infection and infect and damage the joints, skin, and other ... Indications of this can include fever, skin rashes, sores, and joint pain and swelling. In advanced cases, gonorrhea may cause ...
Skin manifestations, specifically rashes, are common; however, there are few detailed descriptions in case reports, and few ... Permethrin is not suitable for use directly on skin.) Most repellent is generally removed from clothing and gear by a single ... Wear long-sleeve shirts, which should be tucked in, long trousers, socks, and hats to cover exposed skin (although most fabrics ... Patients with milder WNF are just as likely as those with more severe manifestations of neuroinvasive disease to experience ...
Spernovasilis N, Psichogiou M, Poulakou G (April 2021). "Skin manifestations of Pseudomonas aeruginosa infections". Curr Opin ... These bacteria do not normally survive on dry, healthy skin, but can thrive in moist conditions. The seal between the nail and ... inflammation of the skin around the nail known as paronychia, and an odour resembling fruit. The colour may range from light or ... Conditions of the skin appendages, Bacterium-related cutaneous conditions, Syndromes). ...
However, skin biopsy helps to diagnose PDP in patients without skin manifestations. When clubbing is observed, it is helpful to ... Like retinoids, colchicines can also improve skin manifestations. It is able to bind to the ends of microtubules to prevent its ... Other drugs used by PDP patients target bone formation or skin manifestations. Surgical care is used to improve cosmetic ... It involves the removal of excess facial skin and tightening of the skin on the face and neck. A second option is plastic ...
"Prognostic Value of Skin Manifestations of Infective Endocarditis". JAMA Dermatology. 150 (5): 494-500. doi:10.1001/ ... "peculiar skin lesions" in some people with endocarditis, in a paper published in 1899. The term was first used by internist and ... Weedon's Skin Pathology (4th ed.). Churchill Livingston. pp. 239-240. ISBN 978-0-7020-5183-8. Servy, Amandine; Valeyrie- ...
"Cellulitis and skin abscess: Clinical manifestations and diagnosis". UpToDate. UpToDate. Retrieved 30 July 2019. Jorup-Rönström ... The disease caused in animals is called Diamond Skin Disease, which occurs especially in pigs. Heart valves and skin are ... While illness symptoms resolve in a day or two, the skin may take weeks to return to normal. Because of the risk of reinfection ... The infection may occur on any part of the skin, including the face, arms, fingers, legs and toes; it tends to favour the ...
The affected individual may exhibit skin purpura and necrosis. Cerebral manifestations may lead to encephalopathy and seizures ... usually occurs with small vessel thromboses affecting organ systems such as the gastrointestinal tract and manifestations of ...
Gammel, J. A. (October 1952). "Erythema gyratum repens; skin manifestations in patient with carcinoma of breast". A.M.A. ... Thickening of the skin of the palms co-exists in around 10% of affected individuals, whatever the underlying cause. The skin ... Inflammatory skin diseases presenting with erythema, urticaria and purpura". Atlas of Dermatology: Inflammatory, Infectious and ... Necrolytic migratory erythema and erythema migrans are some of many other skin conditions that may appear similar. Treatment ...
The skin manifestations are called "blueberry muffin lesions". For these reasons, rubella is included in the TORCH complex of ... The rash disappears after a few days with no staining or peeling of the skin. When the rash clears up, the skin might shed in ...
di Lernia V, Mansouri Y (October 2013). "Epstein-Barr virus and skin manifestations in childhood". International Journal of ... Cherry-Peppers G, Daniels CO, Meeks V, Sanders CF, Reznik D (February 2003). "Oral manifestations in the era of HAART". Journal ... Schooley RT (1988). "Chronic fatigue syndrome: A manifestation of Epstein-Barr virus infection?". Current Clinical Topics in ...
The most common manifestations are hyperpigmentation and haemangiomas. Other skin abnormalities include thickening, ... Mayo Clinic treatment regimens are tailored to treat the clinical manifestations and prognosis for the rate of progression of ... These treatments can relieve many of the syndromes clinical manifestations including neuropathies, have a 10-year overall ... POEMS syndrome can also cause Vascular-type skin changes including acrocyanosis, flushing, hyperaemia, and Raynaud's phenomenon ...
Scott, D. (2001). "Skin Immune System and Allergic Skin Diseases". Muller & Kirk's Small Animal Dermatology. pp. 543-666. doi: ... "Dermatologic manifestations and nutritional management of adverse food reactions". dvm360.com. Retrieved 2017-11-29. ... In cases of feline atopic dermatitis or atopy in cats, pruritic skin diseases may result; however, signs can also include ... Symptoms can include both dermatological and gastrointestinal signs such as itchy skin, hair loss and excessive scratching. ...
Other manifestations include Celiac disease, ulcerative colitis, and ileus. The most common form of skin involvement is ... Other skin manifestations can include cheilitis, onychodystrophy, and alopecia. IPEX patients are usually born with normal ... Scurfy mice have an enlarged spleen and lymph nodes, squinted red eyes, and scaly or "ruffled" skin. The mice also have ...
The most common manifestations involve the heart and skin. Problems involving the liver, gallbladder, brain, and blood can be ... Many of the manifestations are transient, but once complete heart block occurs, it is irreversible. Heart block can be managed ... Cardiac manifestations present more commonly in utero, but can also present after birth. The most common complications are ... Many of the clinical manifestations are transient, but certain heart problems can be permanent. Diagnosis is based on maternal ...
The lepromin skin test is used to determine what type of leprosy a person is infected with. It involves the injection of a ... Dermatologic Manifestations of Leprosy~workup at eMedicine "Ridley Jopling". Retrieved 11 December 2014. "Mitsuda Reaction". ... People who don't have clinical leprosy (Hansen's disease, or HD) may have little or no skin reaction to the antigen, or may ... An extract sample of inactivated Hansen's bacillus is injected just under the skin, usually on the forearm, so that a small ...
Further abnormalities of the skin, genitals, teeth, and skeleton may occur. Other common abnormalities include short head (as ... Acrodysostosis presents with a wide spectrum of clinical manifestations. The following is a list of conditions and ... Further abnormalities of the skin, genitals, teeth, and skeleton may occur. ...
Skin affected by intertrigo is more prone to infection than intact skin. The term "intertrigo" commonly refers to a secondary ... A frequent manifestation is candidal intertrigo. Intertrigo occurs more often in warm and humid conditions. Generally, ... Diaper rash List of skin diseases Kalra, MG; Higgins, KE; Kinney, BS (April 2014). "Intertrigo and secondary skin infections". ... that trap moisture against the skin. Also, there are several skin diseases that can cause an intertrigo to develop, such as ...
The list of manifestation of Shiva:[unreliable source?] Batuk Bhairava Abhiru Akshobhya Bhairava Amar Ambar Amritaksha Asitanga ... He wears a tiger skin and a ritual apron composed of human bones. Bhairava has a dog (Shvan) as his divine vahana (vehicle). ... In Kashmir Shaivism, Bhairava is the ultimate form of manifestation or pure "I" consciousness. One of his forms is called ... There are said to be 52 forms of Bhairava, which are considered a manifestation of Shiva himself. Traditionally, Kala Bhairava ...
Nonallergic reactions may resemble allergy in their manifestations. In some cases, skin tests and provocative challenge may be ... Clinical techniques include: Surface anesthesia is the application of an LA spray, solution, or cream to the skin or a mucous ... The most peripheral technique is topical anesthesia to the skin or other body surface. Small and large peripheral nerves can be ...
It is associated with hyperextensible skin and hypermobility of joints, however symptoms vary depending on the person. Because ... Major manifestations affect the cardiovascular system. Tortuosity and elongation of major and medium sized arteries. Stenosis ... small clusters of enlarged blood vessels just under the skin). Arterial tortuosity syndrome exhibits autosomal recessive ...
Sarcoidosis, an inflammatory disease, involves the skin in about 25% of patients. The most common lesions are erythema nodosum ... 2006). Andrews Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0. Rapini, Ronald P.; Bolognia ... 710 Hypopigmented sarcoidosis is a cutaneous condition characterized by areas of hypopigmented skin. It is usually diagnosed in ... 710 Annular sarcoidosis is a cutaneous condition characterized by papular skin lesions arranged in annular patterns, usually ...
Toxin-mediated staphylococcal syndromes comprise a group of blistering skin diseases, ranging in severity from localized ... Staphylococcal scalded skin syndrome (SSSS) is a toxin-mediated type of exfoliative dermatitis. ... bullous impetigo to staphylococcal scalded skin syndrome, in which superficial blistering and exfoliation follow widespread pai ... Dermatologic Manifestations of Staphylococcal Scalded Skin Syndrome * Sections Dermatologic Manifestations of Staphylococcal ...
Acute urinary retention preceding skin manifestations of genital herpes by 8 days. ... Acute urinary retention preceding skin manifestations of genital herpes by 8 days. ... Acute urinary retention preceding skin manifestations of genital herpes by 8 days. ...
Blastic plasmacytoid dendritic cell neoplasm isnt a skin cancer. Yet, dermatologists might be the first providers to encounter ... But skin manifestations are common with this cancer. According to the Leukemia and Lymphoma Society, skin is involved in 80% of ... Skin manifestations an early sign of rare hematologic cancer. April 13, 2020. Lisette Hilton ... AcneAnti-AgingAtopic Dermatitis BPDCNHair & ScalpNP and PAPsoriasis Rare DiseaseRosaceaSkin Cancer (Melanoma)Skin Cancer (Non- ...
Congested skin 90 (78.3). 82 (79.6). 8 (66.7). 0.290. Conjunctivitis 74 (64.4). 66 (64.1). 6 (66.7). 1.0. ... Clinical Manifestations and Molecular Diagnosis of Scrub Typhus and Murine Typhus, Vietnam, 2015-2017 Nguyen Vu Trung, Le Thi ... Clinical Manifestations and Molecular Diagnosis of Scrub Typhus and Murine Typhus, Vietnam, 2015-2017. ...
Neuro-ophthalmic manifestations are frequently encountered in multiple sclerosis (MS). Affected individuals may experience ... Tuberculin skin testing, chest radiography, or QuantiFERON-TB testing (eg, tuberculosis [TB] exposure, endemic area) ... Afferent Visual Pathway Manifestations of Multiple Sclerosis and Related Disorders. *Efferent Visual Manifestations of Multiple ... Afferent Visual Pathway Manifestations of Multiple Sclerosis and Related Disorders. *Efferent Visual Manifestations of Multiple ...
MAI infection remains a rare cause of skin disease. ... Skin involvement in this setting is not uncommon and includes ... This article reviews the dermatologic manifestations of Mycobacterium avium-intracellulare (MAI, or MAC) infection. Although ... Dermatologic Manifestations of Mycobacterium Avium-Intracellulare Infection * Sections Dermatologic Manifestations of ... and hematogenous seeding of the skin may result in a wide variety of skin lesions, including panniculitis, [3] folliculitis, ...
Skin biopsy: Skin biopsy should be considered to confirm the clinical diagnosis of a cerebriform connective-tissue nevus. See ... encoded search term (Dermatologic Manifestations of Proteus Syndrome) and Dermatologic Manifestations of Proteus Syndrome What ... Dermatologic Manifestations of Proteus Syndrome. Updated: Sep 16, 2022 * Author: Shekhar Neema, MD; Chief Editor: Dirk M Elston ... Evolution of skin lesions in Proteus syndrome. J Am Acad Dermatol. 2005 May. 52(5):834-8. [QxMD MEDLINE Link]. ...
It has been observed that skin manifestations do not typically correlate with disease severity. ... Multiple cases have been reported regarding skin manifestations of COVID-19. It has been observed that skin manifestations do ... One of the most commonly reported skin manifestations of COVID-19 is Pernio or Chilblains (AKA "COVID toes"). Pernio typically ... If you have any of the above rashes or skin lesions, please schedule an appointment to discuss recommendations and treatment ...
Skin Manifestations of Internal Disease - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the MSD ... Signs may include a typical facial appearance, hoarse slow speech, and dry skin. Diagnosis... read more and hyperthyroidism ... progressive skin necrosis of unknown etiology often associated with systemic illness and sometimes skin injury. Diagnosis is ... The skin frequently serves as a marker for underlying internal disease. The type of lesion typically relates to a specific ...
Skin signs in AIDS : textbook of AIDS/HIV infection-related dermatology / Kaare Weismann ... [et al.] by Weismann, Kaare. ... Skin signs of systemic disease / Irwin M. Braverman. by Braverman, Irwin M. ...
... Persechino F.;Galli G.;Persechino S.;Valitutti F.;Zenzeri L.; ... Skin manifestations and coeliac disease in paediatric population / Persechino, F.; Galli, G.; Persechino, S.; Valitutti, F.; ... Skin manifestations and coeliac disease in paediatric population / Persechino, F.; Galli, G.; Persechino, S.; Valitutti, F.; ... This review describes the current scientific evidence on skin manifestations associated with CD in the pediatric population. ...
Our skin is exposed to majority of UV... , Find, read and cite all the research you need on ResearchGate ... Common dermatologic manifestations of aging. Part II: Dermatoses in the elderly, and prevention and.... January 1999 ... Overproduction of ROS in skin cells is one of the reasons for environmental damage of the skin. An increased level of free ... UV radiation is responsible for up to ninety percent of visible skin aging. However, the effects of the sunlight on the skin ...
The extent of skin involvement is quantified by a skin scoring method that correlates involvement with prognosis and is an ... The modified Rodnan skin score is an accurate reflection of skin biopsy thickness in systemic sclerosis. J Rheumatol 25(1):84-8 ... Table 1: Cutaneous manifestations in systemic sclerosis and possible treatment options.. Possible Treatment Regimens. No ... Skin and Diet: An Update on the Role of Dietary Change as a Treatment.... ...
Dealing with the Skin Manifestations of Detoxing blog. by Alexis Cabral , May 5, 2017 , 0 comments ... Getting gorgeous skin involves getting healthy from the inside out! Get our FREE Detox Skin Care Guide which will help you ... pinpoint the root cause of your skin issues and provide a step-by-step guide to tackling them! ...
Addressing the Question of Dermatologic Manifestations of SARS-CoV-2 Infection in the Lower Extremities: A Closer Look at the ... Henry WL, Collins SAB, Resneck JS Jr, et al.: The burden of skin disease in the United States. J Am Acad Dermatol 76: 958, 2020 ... Henry WL, Collins SAB, Resneck JS Jr, et al.: The burden of skin disease in the United States. J Am Acad Dermatol 76: 958, 2020 ... As unequivocal claims of skin manifestations in the lower extremities related to SARS-CoV-2 infection continue to spread with ...
Home / CE Library / COVID-19 Skin Manifestations: Assessment & Intervention [CE/CME Library]. ... COVID-19 Skin Manifestations: Assessment & Intervention [CE/CME Library]. $15.00. COVID-19 Skin Manifestations: Assessment & ...
1. Pathogenesis and clinical manifestations of tularemia * F. tularensis can infect humans through the skin, mucous membranes, ... Untreated, bacilli inoculated into skin or mucous membranes multiply, spread to regional lymph nodes and further multiply, and ... penetrate broken skin, resulting in ulceroglandular or glandular disease; or cause oropharyngeal disease with cervical ...
Skin. 12.6. 17.0. 5.0. 3.89. 1.44-10.55. .008. Kidney. 5.5. 6.8. 4.0. .349. ... P628 Risk Factors Associated with Extraintestinal Manifestations in Patients with Inflammatory Bowel Diseases Liava, C.(1); ... Musculoskeletal and dermatological manifestations were the most frequent EIMs. Aphthous stomatitis, perianal disease, ... Risk factors associated with extraintestinal manifestations (EIMs) in patients with inflammatory bowel disease (IBD) have been ...
All Things Manifestation by Mary Salmas. All Things Manifestation by Mary Salmas. ... Two athletes were excluded from the sample because valorant undetected skin changer buy cheap did not fit within the inclusion ... these principles would warzone skin changer dll reinforced with a territorial development dimension. Download new version of ... falsely claimed that no homosexuals died in the Holocaust and that the pink triangle the Nazis forced imprisoned gays mw 2 skin ...
In 1845, skin lesions were reported by Hebra and later biopsied in 1872 by Kaposi who also pointed to systemic symptoms.1 The ... Ocular manifestations. Ocular manifestations of SLE vary from patient to patient and can correlate to the systemic disease ... Neuro-ophthalmological manifestations. Neuro-ophthalmic manifestations of lupus are not common. The prevalence is 3.6% in ... Neuro-ophthalmologic manifestations of systemic lupus erythematosus: a systematic review. Int J Rheum Dis 2014;17:494-501. doi: ...
Cutaneous manifestations of cirrhosis include jaundice, spider angiomata, skin telangiectasias (termed "paper money skin" by ... Cutaneous manifestations of cirrhosis include jaundice, spider angiomata, skin telangiectasias ("paper money skin"), palmar ... Other Manifestations of Cirrhosis. All chronic liver diseases that progress to cirrhosis have in common the histologic features ... Hematologic manifestations. Anemia may result from folate deficiency, hemolysis, or hypersplenism. [48] Thrombocytopenia ...
Dermatoses is a general term used to describe any skin defect or lesion on the skin. Systemic means it affects the whole body, ... Dermatoses is a general term used to describe any skin defect or lesion on the skin. Systemic means it affects the whole body, ... Dermatoses is a general term used to describe any skin defect or lesion on the skin. Systemic means it affects the whole body, ... Cutaneous manifestations of internal disease. In: Dinulos JGH, ed. Habifs Clinical Dermatology. 7th ed. Philadelphia, PA: ...
Rheumatological manifestations of Diabetes Mellitus may be classified in: non articular, articular and bone conditions. Among ... results in stiff skin and joint contractures. Adhesive capsulitis of the shoulder, flexor tenosynovitis, and Duputryens and ... Rheumatological manifestations of Diabetes Mellitus may be classified in: non articular, articular and bone conditions. Among ... Abstract: Rheumatological manifestations of Diabetes Mellitus may be classified in: non articular, articular and bone ...
This case further emphasizes the wide spectrum of the neurological manifestations of Behcets disease. ... He had recurrent oral ulcerations, bilateral posterior uveitis and retinal vasculitis, skin papules and pustules, and recurrent ... Parkinsonian syndrome as a neurological manifestation of Behçets disease Can J Neurol Sci. 1998 Feb;25(1):82-5. doi: 10.1017/ ... This case further emphasizes the wide spectrum of the neurological manifestations of Behcets disease. ...
In addition to pulmonary symptoms, reports of the involvement of other organs such as the skin are being published. We present ... Although a growing number of cutaneous manifestations of COVID-19 have been reported, there is no doubt that further reports of ... Since COVID-19 manifests in various forms, dermatologists, as thefirst line of dealing with patients who come with skin rashes ... the cases of three COVID-19 patients who presented with cutaneous manifestations and review the previous reports. Purpura and ...
Cutaneous manifestations of the L-tryptophan-associated eosinophilia-myalgia syndrome: a spectrum of sclerodermatous skin ... Dermatologic Manifestations of Eosinophilia-Myalgia Syndrome * Sections Dermatologic Manifestations of Eosinophilia-Myalgia ... encoded search term (Dermatologic Manifestations of Eosinophilia-Myalgia Syndrome) and Dermatologic Manifestations of ... Dermatologic Manifestations of Eosinophilia-Myalgia Syndrome. Updated: Apr 16, 2021 * Author: Robert A Schwartz, MD, MPH; Chief ...
The Skin of Color Society (SOCS) 1932 S. Halsted St., Suite 413 , Chicago, IL 60608 USA , Office: 630-578-3991 , Fax: 630-262- ... Covid-19 Comorbidities and Cutaneous Manifestations of Systemic Diseases in Adults and Children. December 2, 2020 @ 1:00 am - 2 ...
Although the multiple pathophysiological mechanisms still require clarification, similarities in ophthalmic manifestations make ... Ocular Manifestations. In as many as 50% of cases the eye is affected. Ocular circulation might be abnormal when skin lesions ... T. J. Sullivan, M. P. Clarke, and J. D. Morin, "The ocular manifestations of the Sturge-Weber syndrome," Journal of Pediatric ... It would seem reasonable to embody these diseases in a group of their own as there may be diverse manifestations of the same ...
  • Cutaneous manifestations represent the main extraintestinal manifestations, with dermatitis herpetiformis being the most common in patients with CD. (uniroma1.it)
  • In adults, it has been demonstrated that the role of a gluten-free diet is crucial not only for the recovery of signs and symptoms associated with CD but also for cutaneous manifestations, which often improve after gluten avoidance. (uniroma1.it)
  • Dermatologists can assist in the management of these patients by facilitating early diagnosis, and treating cutaneous manifestations such as Raynaud's phenomenon, cutaneous calcinosis, and digital ulceration. (skintherapyletter.com)
  • The purpose of this article is to review the management of the cutaneous manifestations of this disease. (skintherapyletter.com)
  • Cutaneous manifestations of cirrhosis include jaundice, spider angiomata, skin telangiectasias ("paper money skin"), palmar erythema, white nails, disappearance of lunulae, and finger clubbing, especially in the setting of hepatopulmonary syndrome. (medscape.com)
  • We present the cases of three COVID-19 patients who presented with cutaneous manifestations and review the previous reports. (iranjd.ir)
  • Although a growing number of cutaneous manifestations of COVID-19 have been reported, there is no doubt that further reports of both typical and atypical presentations are needed to confirm and understand skin involvement in COVID-19. (iranjd.ir)
  • 710 Annular sarcoidosis is a cutaneous condition characterized by papular skin lesions arranged in annular patterns, usually with a red-brown hue. (wikipedia.org)
  • 709 Morpheaform sarcoidosis is a very rare cutaneous condition characterized by specific cutaneous skin lesions of sarcoidosis accompanied by substantial fibrosis, simulating morphea. (wikipedia.org)
  • skin lesions. (nih.gov)
  • If you have any of the above rashes or skin lesions, please schedule an appointment to discuss recommendations and treatment plans. (pdxderm.com)
  • Evaluation of the Dermatologic Patient History and physical examination are adequate for diagnosing many skin lesions. (msdmanuals.com)
  • In 1845, skin lesions were reported by Hebra and later biopsied in 1872 by Kaposi who also pointed to systemic symptoms. (bmj.com)
  • In secondary syphilis, fever, swollen lymph nodes and skin rash, and wart-like genital lesions (condyloma lata) can be seen. (cdc.gov)
  • Skin lesions caused by systemic lupus erythematosus are among the most frequent manifestations of this disease. (nih.gov)
  • Skin lesions include malar butterfly erythema (flat or raised) that generally spares the nasolabial folds. (merckmanuals.com)
  • When a disease affects one part of the connective tissue, it can also have manifestations in another part, for example, with activation of the Crohn's disease - there can be skin lesions as well. (gulfnews.com)
  • 2006). Andrews' Diseases of the Skin: clinical Dermatology. (wikipedia.org)
  • Toxin-mediated staphylococcal syndromes comprise a group of blistering skin diseases, ranging in severity from localized bullous impetigo to SSSS. (medscape.com)
  • Skin and rheumatic diseases. (medlineplus.gov)
  • Although the multiple pathophysiological mechanisms still require clarification, similarities in ophthalmic manifestations make it reasonable to classify these diseases in an independent group. (hindawi.com)
  • Various pathophysiological mechanisms have been proposed, but the clinical similarities, ophthalmic manifestations in particular, make it reasonable to classify these diseases as an independent group. (hindawi.com)
  • First Year Dentistry Mind Map on Periodontitis as a Manifestation of Systemic diseases, created by sanna pathy on 03/07/2020. (goconqr.com)
  • Many, many intestinal diseases have cutaneous (skin) manifestations. (gulfnews.com)
  • Knowledge of many of the skin manifestations in the setting of cardiac diseases has become very important and is immensely helpful for proper diagnosis and treatment of patients with cardiovascular disorders. (medscape.com)
  • In children with CD, the association with skin disorders is well documented regarding dermatitis herpetiformis, but studies considering other dermatological conditions, such as psoriasis and atopic dermatitis, are few. (uniroma1.it)
  • The prevalence and manifestations of dermatological disorders in celiac children are often different from those in adults, explaining the gap between these populations. (uniroma1.it)
  • Musculoskeletal and dermatological manifestations were the most frequent EIMs. (ecco-ibd.eu)
  • Dermatological manifestations occur in more than 70% of patients with Fabry disease, with a mean age of onset at 17 years [3]. (dermnetnz.org)
  • There is a well-established relationship between gastrointestinal health and skin health, and we call it the 'gut-skin' axis, which has become an important topic in dermatological research," says Dr Diane Maalouf, specialist dermatologist at American Hospital, Dubai. (gulfnews.com)
  • Skin biopsy: Skin biopsy should be considered to confirm the clinical diagnosis of a cerebriform connective-tissue nevus. (medscape.com)
  • Since COVID-19 manifests in various forms, dermatologists, as the first line of dealing with patients who come with skin rashes, should always be aware of the early diagnosis of this disease. (iranjd.ir)
  • I am a board-certified dermatologist who specializes in the diagnosis and treatment of various skin conditions - particularly skin cancers including melanoma (the most dangerous form of skin cancer), genetic skin disorders, drug hypersensitivity reaction, therapy-induced skin toxicity, and skin manifestations of infections in immune-compromised individuals. (mskcc.org)
  • It is imperative for ophthalmologists to be aware of the early ophthalmological manifestations of AML which will allow for earlier diagnosis and treatment of this life-threatening disease. (dovepress.com)
  • 11 The purpose of this review is to present and evaluate the medical literature on the early ophthalmological manifestations of acute myeloid leukemia, which physicians should be aware of for an earlier and more efficient diagnosis and treatment. (dovepress.com)
  • For example, the diagnosis of acute rheumatic fever in patients presenting with acute carditis includes 2 skin signs out of the 5 classic Jones criteria (ie, arthritis, carditis, erythema marginatum, subcutaneous nodules, and chorea). (medscape.com)
  • This article reviews the dermatologic manifestations of Mycobacterium avium-intracellulare (MAI, or MAC) infection. (medscape.com)
  • Cardiovascular disorders and therapies are often associated with a variety of dermatologic manifestations. (medscape.com)
  • In some patients, the dermatologic manifestations represent a component of a full systemic or vascular disorder that also involves defects in the cardiovascular system as another accompanying component. (medscape.com)
  • Advanced medical and invasive therapies have led to recognition of many new dermatologic manifestations, for example, angioedema from ACE inhibitors, ankle swelling due to calcium channel blockers, or radiation skin burns following prolonged angioplasty and radiation exposure. (medscape.com)
  • In this article, a discussion of some of the more common and clinically relevant dermatologic manifestations encountered in cardiac patients is reviewed, along with plausible differentials as applicable. (medscape.com)
  • Ocular manifestations of SLE are common and may lead to permanent blindness from the underlying disease or therapeutic side effects. (bmj.com)
  • Ocular symptoms are correlated to systemic disease activity and can present as an initial manifestation of SLE. (bmj.com)
  • AML affects the ocular system through direct infiltration of tissues, secondary to hematological abnormalities, or in the form of chloroma or myeloid sarcoma in the brain or orbit consequently leading to a variety of manifestations depending on the ocular tissue involved. (dovepress.com)
  • Neuro-ophthalmic manifestations frequently are encountered in persons with multiple sclerosis (MS) and other central nervous system (CNS) inflammatory disorders, including neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody associated disease (MOGAD). (medscape.com)
  • Ophthalmic manifestations of leukemia are more frequent with acute than chronic leukemia and can affect all intraocular structures. (dovepress.com)
  • PubMed, Embase, and Science Direct databases were searched with the keywords [(Acute Myeloid Leukemia) OR (AML)] AND (Ophthalmic Manifestations). (dovepress.com)
  • Infants might be born without clinical signs of syphilis but go on to develop late-stage manifestations of untreated congenital syphilis that include developmental delay, neurologic manifestations and late congenital syphilis physical signs. (cdc.gov)
  • A great variety of extraintestinal manifestations may be associated with CD. (uniroma1.it)
  • Risk factors associated with extraintestinal manifestations (EIMs) in patients with inflammatory bowel disease (IBD) have been evaluated mainly in retrospective studies. (ecco-ibd.eu)
  • F. tularensis can infect humans through the skin, mucous membranes, gastrointestinal tract, and lungs. (cdc.gov)
  • Other less common chronic manifestations involve the pulmonary, cardiac, and gastrointestinal systems. (medscape.com)
  • Brief discussions of the risk factors, epidemiology and natural history, and prevention of food allergies are followed by details on the cutaneous, gastrointestinal, and respiratory manifestations of food allergy. (netce.com)
  • There is a well-established relationship between gastrointestinal health and skin health, and we call it the 'gut-skin' axis. (gulfnews.com)
  • And the other two manifestations are gastrointestinal disease or skin disease. (cdc.gov)
  • In this review article, we summarize current knowledge of the possible skin manifestations of pancreatic disorders. (nih.gov)
  • On another hand, an imbalance in your gut's microorganism universe, or microbiome (also called dysbiosis) has the potential to negatively impact the skin microbiome, which contributes to common skin disorders such as acne, atopic dermatitis, rosacea, hidradeinitis suppurativa and psoriasis," adds Dr Maalouf. (gulfnews.com)
  • Blastic plasmacytoid dendritic cell neoplasm is a rare, aggressive hematologic malignancy that may manifest on the skin and may have leukemic dissemination," Larisa J. Geskin, M.D., president of the International Society for Cutaneous Lymphomas, told Dermatology Times. (dermatologytimes.com)
  • Skin manifestations in three cases of COVID-19 infection from Iran and a narrative literature review', Iranian Journal of Dermatology , 23(Suppl.1(COVID-19)), pp. 60-66. (iranjd.ir)
  • Skin signs of systemic disease / Irwin M. Braverman. (who.int)
  • Ophthalmic involvement can be the initial manifestation of the systemic disease or the first sign of relapse. (dovepress.com)
  • Sarcoidosis, an inflammatory disease, involves the skin in about 25% of patients. (wikipedia.org)
  • These include skin symptoms, such as pancreatic panniculitis, acanthosis nigricans, livedo reticularis, necrolytic migratory erythema, cutaneous signs of hemorrhage, as in persons with severe acute pancreatitis, or the finding of cutaneous metastases of pancreatic carcinoma, which may be a sign of advanced disease. (nih.gov)
  • Skin findings do not always correlate with disease stage in blastic plasmacytoid dendritic cell neoplasm patients. (dermatologytimes.com)
  • [ 1 ] Although the prevalence of MAI infection has increased following the epidemic of acquired immunodeficiency syndrome (AIDS), MAI infection remains a rare cause of skin disease. (medscape.com)
  • Disease may present primarily in the skin with later dissemination. (medscape.com)
  • however, the literature suggests that the risk of skin involvement increases with advanced disease. (medscape.com)
  • It has been observed that skin manifestations do not typically correlate with disease severity. (pdxderm.com)
  • The skin frequently serves as a marker for underlying internal disease. (msdmanuals.com)
  • 13 Aberrant epigenetic regulation including DNA methylation, histone modifications and microRNA-mediated regulation may contribute to the complex array of immune abnormalities and disease manifestations in SLE. (bmj.com)
  • Fabry disease causes clusters of angiokeratomas (small, dark red spots on the skin) and many systemic symptoms due to the deposition of globotriaosylceramide (Gb3) in multiple organs. (dermnetnz.org)
  • Manifestations of the disease cause considerable morbidity and social cost. (aafp.org)
  • 1. Intro Psoriasis is an autoimmune disease characterized by itchy, reddish, and scaly pores and skin patches [1]. (racetab.org)
  • John Jernigan] Not respiratory disease, which is a little bit of an unusual manifestation. (cdc.gov)
  • Differences between the two types of patients were discussed with respect to age, radiographic changes, and extrapulmonary manifestations of disease. (cdc.gov)
  • How do you deal with complex clinical manifestations of conditions, such as signs (visually observable patient abnormalities), symptoms (abnormal perceptions of illness that only the patients can report, such as pain, itching, fatigue, depressive feelings), and syndromes (clusters of signs, symptoms, and other clinical phenomena that may or may not be indicative of a specific underlying disease)? (cdc.gov)
  • The extent of skin involvement is quantified by a skin scoring method that correlates involvement with prognosis and is an accurate reflection of skin biopsy thickness. (skintherapyletter.com)
  • Long term care is important to prevent and treat chronic manifestations of filariasis. (bmj.com)
  • In addition to pulmonary symptoms, reports of the involvement of other organs such as the skin are being published. (iranjd.ir)
  • Clinical manifestations of tropical pulmonary eosinophilia syndrome include cough, shortness of breath, and wheezing. (cdc.gov)
  • Common manifestations may include arthralgias and arthritis, Raynaud syndrome, malar and other rashes, pleuritis or pericarditis, renal or central nervous system involvement, and autoimmune cytopenias. (merckmanuals.com)
  • The distribution of desmogleins in the epidermis explains the preferential blistering of SSSS in the superficial skin and lack of blistering in mucous membranes. (medscape.com)
  • Untreated, bacilli inoculated into skin or mucous membranes multiply, spread to regional lymph nodes and further multiply, and then may disseminate to organs throughout the body. (cdc.gov)
  • Cyanosis is a bluish discoloration of the skin and mucous membranes due to an increased amount of reduced hemoglobin in the small blood vessels of the skin. (medscape.com)
  • In the central type, the desaturation of the arterial blood affects both the mucous membranes and the skin. (medscape.com)
  • 15 The key role of aberrant B cell autoreactivity in SLE was revealed in a landmark murine study using a knockout gene mutation to prevent lupus mice from developing B cells, which resulted in a lack of autoantibody formation and clinical manifestations (nephritis or vasculitis). (bmj.com)
  • Las lesiones en la piel producidas por el lupus eritematoso sistémico constituyen una de las manifestaciones más frecuentes de esta enfermedad. (nih.gov)
  • Acute urinary retention preceding skin manifestations of genital herpes by 8 days. (bmj.com)
  • We rarely use sunscreens during those activities, or at least not as much and as regular as we should and are commonly prone to acute and chronic sun damage of the skin. (researchgate.net)
  • Joint symptoms, ranging from intermittent arthralgias to acute polyarthritis, occur in about 90% of patients and may precede other manifestations by years. (merckmanuals.com)
  • The purpose of this review is to present and evaluate the medical literature regarding the early ophthalmological manifestations of acute myeloid leukemia. (dovepress.com)
  • SSSS is a systemic toxigenic process producing constitutional symptoms and widespread superficial blistering and exfoliation of the skin following generalized painful erythema. (medscape.com)
  • The pathogenesis of psoriasis entails the abnormally quick growth of the skin epidermis. (racetab.org)
  • When joint manifestations or fatigue predominates, the differential is expanded further. (aafp.org)
  • The histology of cerebriform connective-tissue nevi and epidermal nevi are discussed in Physical Examination , along with a description of their clinical manifestations. (medscape.com)
  • This cell-mediated immune response is ultimately responsible for the widespread tissue injury, in addition to the fibrosis of the skin and the connective tissue that pervades muscles, nerves, and other organs. (medscape.com)
  • Dr Rakesh Sugathan, senior consultant and head of department of gastroenterology at PRS Hospital, Kerala, India, says, "This is all related to connective tissue and also inflammation - anything that affects the intestinal connective tissue can affect skin cutaneous tissue. (gulfnews.com)
  • Staphylococcal scalded skin syndrome (SSSS) is a toxin-mediated exfoliative dermatitis. (medscape.com)
  • The fastest clinical effect is achieved when pathological process is accompanied by expressed painful syndrome or local manifestation, has no expressed organo-structural changes and is located in tissues. (kalinka-store.com)
  • [ 1 ] Certain congenital cardiac defects are associated with unique skin manifestations, such as coarctation of the aorta associated with external features of Turner syndrome or atrioventricular (AV) septal defects associated with skin features of Down syndrome. (medscape.com)
  • We describe a patient with IVL of the skin as a manifestation of a recurrent diffuse large B-cell lymphoma of ureteral origin. (elsevierpure.com)
  • 5 Treatment of involved skin includes frequent use of emollients and physical protection from temperature extremes and abrasion. (skintherapyletter.com)
  • Among non articular conditions, diabetic cheiroarthropathy, frequent in type I diabetes, the most important disorder related to limited joint mobility, results in stiff skin and joint contractures. (benthamscience.com)
  • After recurrence in the skin, lymphoma cells gradually located only in the vascular lumina. (elsevierpure.com)
  • He had a skin biopsy but developed severe abdominal pain before being diagnosed and presented to the emergency department for the pain. (dermatologytimes.com)
  • The initial skin biopsy results showed the immunophenotype was the same as the bone-marrow biopsy except for being CD56−, the authors wrote. (dermatologytimes.com)
  • An additional ET family member, ET-D, has been identified by screening the genomes of S. aureus isolated from patients with skin infections. (medscape.com)
  • The ET-D gene was detected mainly in isolates from patients with skin and soft-tissue infections, namely furuncles, abscesses, and finger pulp infections. (medscape.com)
  • Affected persons will have more bacterial infections in the skin and lymph system. (cdc.gov)
  • Many of these bacterial infections can be prevented with appropriate skin hygiene and care for wounds. (cdc.gov)
  • Signs may include a typical facial appearance, hoarse slow speech, and dry skin. (msdmanuals.com)
  • Clinical manifestations of early congenital syphilis might include rhinitis ("snuffles"), hepatosplenomegaly, skin rash with desquamation, chorioretinitis and pigmentary chorioretinopathy (salt and pepper type), glaucoma, cataracts, interstitial keratitis, optic neuritis, periostitis and cortical demineralization of metaphysis and diaphysis areas of long bones, anaemia and thrombocytopenia. (cdc.gov)
  • Good skin health needs to include good skincare, there's no denying that, but it also needs to consider what's going on in the inside. (gulfnews.com)
  • Because of its early manifestations on the skin, dermatologists are well positioned to diagnose it early. (dermatologytimes.com)
  • Extra-articular (non-joint related) manifestations of RA are less common but may require higher level of immunosuppression. (nationaljewish.org)
  • The most clinically significant sites of accumulation of Gb3 are blood vessels of the skin, heart, nerves , and kidneys [8]. (dermnetnz.org)
  • Spider angiomata (small, dilated blood vessels clustered very close to the surface of the skin. (rarediseases.org)
  • Porphyria Cutanea Tarda Porphyria cutanea tarda (PCT) is a comparatively common hepatic porphyria affecting mainly the skin. (msdmanuals.com)
  • Keratoconjunctivitis sicca is the most common manifestation. (bmj.com)
  • UV-induced photoaging of the skin becomes clinically evident with age, when endogenous antioxidative mechanisms and repair processes are not effective any more and actinic damage to the skin prevails. (researchgate.net)
  • Many skin findings are associated with endocrinopathies but are not specific. (msdmanuals.com)
  • DSG1 is a desmosomal cadherin protein that mediates cell-to-cell adhesion of keratinocytes in all layers of the epidermis, including the skin and mucosa, but is in greatest abundance within the stratum granulosa. (medscape.com)
  • Recognize the clinical manifestations of actinic cheilosis. (dentalcare.com)
  • Losurdo G, Principi M, Iannone A, Amoruso A, Ierardi E, Di Leo A, Barone M. Extra-intestinal manifestations of non-celiac gluten sensitivity: An expanding paradigm. (wjgnet.com)
  • In addition, the therapeutic role of a gluten-free diet in the improvement in skin alterations is not fully understood in children and in adult population except for dermatitis herpetiformis. (uniroma1.it)
  • Data on skin and soft-tissue infection caused by nontuberculous mycobacteria in Taiwan (1997-2008) suggest that MAI is an important pathogen. (medscape.com)
  • She says that research has shown that skin and gut microorganism universes, or microbiota, are able to interact with our immune systems to help keep away inflammation by stopping the growth of 'bad' bacteria. (gulfnews.com)
  • This phase lasts weeks to months and is followed by a chronic phase characterized by sclerodermoid skin changes, neuropathy, neurocognitive deficits, continued myalgia, and muscle cramps. (medscape.com)
  • In this paper, the authors present a secondary CBCL case with a three-year evolution, indolent course, without involvement of other organs beside the skin and with optimal response to chemotherapeutic treatment. (scielo.br)
  • Results of search for 'su:{Skin manifestations. (who.int)