Spinal Cord Vascular Diseases
Spinal Cord
Spinal Cord Injuries
Vascular Diseases
Spinal Cord Diseases
Spinal Cord Compression
Spinal Cord Neoplasms
Peripheral spinal cord hypointensity on T2-weighted MR images: a reliable imaging sign of venous hypertensive myelopathy. (1/17)
BACKGROUND AND PURPOSE: MR findings reported in conjunction with spinal dural arteriovenous fistula (SDAVF) include cord swelling, increased T2 signal within the spinal cord, and parenchymal enhancement, each of which is nonspecific. Enlarged vessels on the cord surface, the most specific MR finding, is noted in only half of SDAVF patients. Nevertheless, we have frequently observed MR peripheral hypointensity of the spinal cord in SDAVF on T2-weighted images, which is not characteristic of nonvascular or nonhemorrhagic causes of myelopathy and which has not been described in association with SDAVF. We hypothesized that peripheral cord hypointensity might reliably suggest the diagnosis of SDAVF or other causes of venous hypertensive myelopathy. METHODS: We reviewed the MR findings in 11 consecutive cases of angiographically confirmed symptomatic SDAVF and in four cases of intracranial dural arteriovenous fistula with spinal drainage, a lesion that also causes spinal cord deficits mediated by venous hypertensive myelopathy. RESULTS: In each case, T2 hypointensity involving the cord periphery was present. This sign has not been previously described in association with either SDAVF or other causes of venous hypertensive myelopathy. It appears, however, to be a relatively constant imaging feature of SDAVF. CONCLUSION: In the absence of spinal hemorrhage, T2 hypointensity involving the periphery of the spinal cord suggests venous hypertensive myelopathy as a cause of spinal cord dysfunction. (+info)Neurovascular complications of marfan syndrome: a retrospective, hospital-based study. (2/17)
BACKGROUND AND PURPOSE: Small case series have associated Marfan syndrome with cerebral and spinal ischemia or hemorrhage. However, there has been no investigation of the frequency and etiology of neurovascular disorders in a large series of Marfan patients. METHODS: We conducted a retrospective, hospital-based study of all Marfan syndrome patients seen in an 8-year period. Records were reviewed in detail, and clinical characteristics of those with and without a neurovascular diagnosis compared. RESULTS: Of 513 patients, 18 (3.5%) had a neurovascular diagnosis, as follows: transient ischemic attack (11), cerebral infarction (2), spinal cord infarction (2), subdural hematoma (2), and spinal subarachnoid hemorrhage (1). A cardioembolic source was identified in 12 of 13 patients with cerebral ischemia, as follows: prosthetic heart valves (9), mitral valve prolapse (2), and atrial fibrillation (1). Chronic anticoagulant therapy was a likely cause in 2 of 3 patients with hemorrhagic events. Compared with other Marfan syndrome patients, those with neurovascular events were older (39.6 versus 31.7 years, P=0.04) and more likely to be in atrial fibrillation (22.2% versus 3.2%, P=<0.01), to have prosthetic heart valves (61.1% versus 7.7%, P=0.001), and to be taking anticoagulant therapy (72.2% versus 16.1%, P<0.001). Aortic disease, a putative factor in the etiology of neurovascular complications, was present in equal measure in Marfan patients with and without neurovascular complications (78% versus 65%, P=NS). CONCLUSIONS: Neurovascular complications of Marfan syndrome are rare during 8 years of follow-up, and generally are ischemic in nature. A high-risk cardiac source was identified in the majority. A significant association with vascular dissection was not established. (+info)Spinal tanycytic ependymoma with hematomyelia--case report--. (3/17)
A 58-year-old man presented with an extremely rare case of "pure type" spinal tanycytic ependymoma associated with hematomyelia manifesting as sensory disturbance of the bilateral hands and weakness of the right arm. Magnetic resonance imaging demonstrated a tumor in the spinal cord from C-2 to C-4 levels. The soft gelatinous tumor was subtotally resected and the adjacent chronic liquid hematoma was aspirated. The immunohistochemical and ultrastructural findings indicated a diagnosis of tanycytic ependymoma. (+info)Transient traumatic spinal venous hypertensive myelopathy. (4/17)
We present a case of a reversible spinal venous hypertensive myelopathy that occurred following a traumatic mediastinal hematoma. The mediastinal hematoma caused compression of the brachiocephalic vein, resulting in elevation of the venous pressures that ultimately resulted in dilation of the epidural venous plexus and spinal cord edema. The secondary neurologic deficits were the culmination of venous outflow obstruction at the level of the spinal cord that resolved on the resolution of the mediastinal hematoma. (+info)Usefulness of combined electrophysiological examinations for detection of neural dysfunction in cats with lumbar hematomyelia. (5/17)
We conducted combined electrophysiological examinations including F-wave, motor nerve conduction velocity (MNCV), spinal cord-evoked potential (SCEP), and needle electromyography (EMG) in two cats involved in traffic accidents that consequently developed hind limb paralysis caused by lumbar hematomyelia. F-wave could no longer be elicited within 3 days after the accident, and the MNCV and compound muscle action potential (CMAP) amplitude decreased in a time-dependent manner, with CMAP no longer being evoked after 7 or 8 days. EMG showed abnormalities such as fibrillation and positive sharp waves after 6 to 8 days. These results suggest that such combined electrophysiological examinations may provide objective, quantitative data for motor nerve dysfunction in cats with lumbar hematomyelia. (+info)Spinal arteriovenous shunts presenting as intracranial subarachnoid haemorrhage. (6/17)
BACKGROUND: In approximately 5% of patients with intracranial subarachnoid haemorrhage (SAH), the cause is another than a ruptured aneurysm or perimesencephalic haemorrhage. One of these causes is a spinal arteriovenous shunt (SAVS). The aim of this study was to investigate the characteristics of patients with SAVS who present with intracranial SAH without symptoms and signs suggesting a spinal cause. METHODS: We systematically reviewed the literature and searched the SAH database of the University Medical Center Utrecht, The Netherlands, for patients with SAVS presenting with intracranial SAH and studied the characteristics of patients with SAVS whose clinical presentation mimicked intracranial SAH caused by rupture of a saccular aneurysm. RESULTS: Thirty-five patients were identified after a review of the literature. In our SAH database, comprising 2142 patients included in the period 1985-2004, we found one patient (0.05%, 95 % CI 0.006- 0.3%). SAH due to SAVS occurred at any age (4-72 years). The SAVS was located at the craniocervical junction in 14 patients, at the cervical level in 11, and at the thoracolumbar level in the remaining 11 patients. The majority of patients (n = 26, 72%) had no disabling deficits at discharge or follow-up. CONCLUSION: Rupture of a SAVS presenting as intracranial SAH is rare and can occur at any age. The SAVS can be located not only at the craniocervical junction or cervical level but also in the thoracolumbar region. Most patients with SAVS presenting as intracranial SAH have a good recovery. (+info)Hematomyelia caused by ruptured intramedullary spinal artery aneurysm associated with extramedullary spinal arteriovenous fistula--case report. (7/17)
A 53-year-old woman presented with a ruptured intramedullary aneurysmal dilatation fed by the anterior spinal artery associated with an arteriovenous malformation located in the ventral cervical spinal cord. She developed tetraparesis and respiratory dysfunction. The neurological deterioration was caused by hematomyelia due to the ruptured aneurysmal dilatation and progression of edema in the upper cervical spinal cord due to venous hypertension associated with additional hematoma in the medulla oblongata. Endovascular embolization of both C-1 and C-2 radicular arteries was performed with Guglielmi detachable coils, but components fed by small branches such as the radiculo-pial artery were not obliterated. Surgery was performed for extirpation of the arteriovenous malformation and cervical intramedullary hematoma, and excision of the aneurysmal dilatation through a transcondylar approach combined with vertebral artery transposition. Postoperatively, she overcame several complications such as pneumonia and endocarditis, and had only moderate weakness of the right upper and lower limbs. This case indicates that surgical intervention for high cervical intramedullary lesion may be very effective. (+info)Intramedullary cavernoma presenting with hematomyelia: report of two girls. (8/17)
(+info)Spinal cord vascular diseases refer to a group of disorders that affect the blood vessels of the spinal cord. These conditions can result in insufficient blood supply to the spinal cord tissue, leading to ischemia (lack of oxygen) and infarction (tissue death). There are several types of spinal cord vascular diseases, including:
1. Spinal Cord Infarction: This is a rare condition that occurs due to the blockage or narrowing of the arteries supplying blood to the spinal cord. It can result in sudden onset of weakness, numbness, or paralysis in parts of the body served by the affected spinal cord region.
2. Spinal Cord Aneurysm: This is a localized dilation or bulging of a weakened area in the wall of a blood vessel that supplies the spinal cord. If an aneurysm ruptures, it can cause bleeding into the spinal cord tissue, leading to neurological deficits.
3. Spinal Cord Arteriovenous Malformations (AVMs): These are abnormal connections between the arteries and veins in the spinal cord. AVMs can lead to bleeding, ischemia, or both, resulting in various neurological symptoms.
4. Spinal Cord Dural Arteriovenous Fistulas (dAVFs): These are abnormal communications between the spinal artery and a vein located outside the dura mater (the protective covering of the spinal cord). dAVFs can cause venous congestion, leading to ischemia and neurological dysfunction.
5. Spinal Cord Vasculitis: This is an inflammation of the blood vessels in the spinal cord, which can lead to narrowing or blockage of the affected vessels. It can result in various neurological symptoms, such as weakness, numbness, or pain.
Treatment for spinal cord vascular diseases depends on the specific condition and its severity. Treatment options may include medications, surgery, endovascular procedures, or a combination of these approaches.
The spinal cord is a major part of the nervous system, extending from the brainstem and continuing down to the lower back. It is a slender, tubular bundle of nerve fibers (axons) and support cells (glial cells) that carries signals between the brain and the rest of the body. The spinal cord primarily serves as a conduit for motor information, which travels from the brain to the muscles, and sensory information, which travels from the body to the brain. It also contains neurons that can independently process and respond to information within the spinal cord without direct input from the brain.
The spinal cord is protected by the bony vertebral column (spine) and is divided into 31 segments: 8 cervical, 12 thoracic, 5 lumbar, 5 sacral, and 1 coccygeal. Each segment corresponds to a specific region of the body and gives rise to pairs of spinal nerves that exit through the intervertebral foramina at each level.
The spinal cord is responsible for several vital functions, including:
1. Reflexes: Simple reflex actions, such as the withdrawal reflex when touching a hot surface, are mediated by the spinal cord without involving the brain.
2. Muscle control: The spinal cord carries motor signals from the brain to the muscles, enabling voluntary movement and muscle tone regulation.
3. Sensory perception: The spinal cord transmits sensory information, such as touch, temperature, pain, and vibration, from the body to the brain for processing and awareness.
4. Autonomic functions: The sympathetic and parasympathetic divisions of the autonomic nervous system originate in the thoracolumbar and sacral regions of the spinal cord, respectively, controlling involuntary physiological responses like heart rate, blood pressure, digestion, and respiration.
Damage to the spinal cord can result in various degrees of paralysis or loss of sensation below the level of injury, depending on the severity and location of the damage.
Spinal cord injuries (SCI) refer to damage to the spinal cord that results in a loss of function, such as mobility or feeling. This injury can be caused by direct trauma to the spine or by indirect damage resulting from disease or degeneration of surrounding bones, tissues, or blood vessels. The location and severity of the injury on the spinal cord will determine which parts of the body are affected and to what extent.
The effects of SCI can range from mild sensory changes to severe paralysis, including loss of motor function, autonomic dysfunction, and possible changes in sensation, strength, and reflexes below the level of injury. These injuries are typically classified as complete or incomplete, depending on whether there is any remaining function below the level of injury.
Immediate medical attention is crucial for spinal cord injuries to prevent further damage and improve the chances of recovery. Treatment usually involves immobilization of the spine, medications to reduce swelling and pressure, surgery to stabilize the spine, and rehabilitation to help regain lost function. Despite advances in treatment, SCI can have a significant impact on a person's quality of life and ability to perform daily activities.
Vascular diseases are medical conditions that affect the circulatory system, specifically the blood vessels (arteries, veins, and capillaries). These diseases can include conditions such as:
1. Atherosclerosis: The buildup of fats, cholesterol, and other substances in and on the walls of the arteries, which can restrict blood flow.
2. Peripheral Artery Disease (PAD): A condition caused by atherosclerosis where there is narrowing or blockage of the peripheral arteries, most commonly in the legs. This can lead to pain, numbness, and cramping.
3. Coronary Artery Disease (CAD): Atherosclerosis of the coronary arteries that supply blood to the heart muscle. This can lead to chest pain, shortness of breath, or a heart attack.
4. Carotid Artery Disease: Atherosclerosis of the carotid arteries in the neck that supply blood to the brain. This can increase the risk of stroke.
5. Cerebrovascular Disease: Conditions that affect blood flow to the brain, including stroke and transient ischemic attack (TIA or "mini-stroke").
6. Aneurysm: A weakened area in the wall of a blood vessel that causes it to bulge outward and potentially rupture.
7. Deep Vein Thrombosis (DVT): A blood clot that forms in the deep veins, usually in the legs, which can cause pain, swelling, and increased risk of pulmonary embolism if the clot travels to the lungs.
8. Varicose Veins: Swollen, twisted, and often painful veins that have filled with an abnormal collection of blood, usually appearing in the legs.
9. Vasculitis: Inflammation of the blood vessels, which can cause damage and narrowing, leading to reduced blood flow.
10. Raynaud's Phenomenon: A condition where the small arteries that supply blood to the skin become narrowed, causing decreased blood flow, typically in response to cold temperatures or stress.
These are just a few examples of vascular conditions that fall under the umbrella term "cerebrovascular disease." Early diagnosis and treatment can significantly improve outcomes for many of these conditions.
Spinal cord diseases refer to a group of conditions that affect the spinal cord, which is a part of the central nervous system responsible for transmitting messages between the brain and the rest of the body. These diseases can cause damage to the spinal cord, leading to various symptoms such as muscle weakness, numbness, pain, bladder and bowel dysfunction, and difficulty with movement and coordination.
Spinal cord diseases can be congenital or acquired, and they can result from a variety of causes, including infections, injuries, tumors, degenerative conditions, autoimmune disorders, and genetic factors. Some examples of spinal cord diseases include multiple sclerosis, spina bifida, spinal cord injury, herniated discs, spinal stenosis, and motor neuron diseases such as amyotrophic lateral sclerosis (ALS).
The treatment for spinal cord diseases varies depending on the underlying cause and severity of the condition. Treatment options may include medication, physical therapy, surgery, and rehabilitation. In some cases, the damage to the spinal cord may be irreversible, leading to permanent disability or paralysis.
Spinal cord compression is a medical condition that refers to the narrowing of the spinal canal, which puts pressure on the spinal cord and the nerves that branch out from it. This can occur due to various reasons such as degenerative changes in the spine, herniated discs, bone spurs, tumors, or fractures. The compression can lead to a range of symptoms including pain, numbness, tingling, weakness, or loss of bladder and bowel control. In severe cases, it can cause paralysis. Treatment options depend on the underlying cause and may include physical therapy, medication, surgery, or radiation therapy.
Spinal cord neoplasms refer to abnormal growths or tumors within the spinal cord. These can be benign (non-cancerous) or malignant (cancerous). They originate from the cells within the spinal cord itself (primary tumors), or they may spread to the spinal cord from other parts of the body (metastatic tumors). Spinal cord neoplasms can cause various symptoms depending on their location and size, including back pain, neurological deficits, and even paralysis. Treatment options include surgery, radiation therapy, and chemotherapy.
Peripheral Vascular Diseases (PVD) refer to a group of medical conditions that affect the blood vessels outside of the heart and brain. These diseases are characterized by a narrowing or blockage of the peripheral arteries, which can lead to reduced blood flow to the limbs, particularly the legs.
The primary cause of PVD is atherosclerosis, a buildup of fats, cholesterol, and other substances in and on the walls of the arteries, forming plaques that restrict blood flow. Other risk factors include smoking, diabetes, hypertension, high cholesterol levels, and a family history of vascular disease.
Symptoms of PVD can vary depending on the severity of the condition but may include leg pain or cramping during exercise (claudication), numbness or tingling in the legs, coldness or discoloration of the feet, sores or wounds that heal slowly or not at all, and in severe cases, gangrene.
PVD can increase the risk of heart attack and stroke, so it is essential to diagnose and treat the condition as early as possible. Treatment options include lifestyle changes such as quitting smoking, exercising regularly, and maintaining a healthy diet, medications to control symptoms and reduce the risk of complications, and surgical procedures such as angioplasty or bypass surgery to restore blood flow.
Peter Staats
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Arteriovenous Malformations and Fistulas (AVM/AVF) of the Spinal Cord: Practice Essentials, Background, History of the Procedure
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Spinal Cord Hemorrhage: Background, Pathophysiology, Epidemiology
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Peripheral vascula3
- [ 13 ] Also, a 20-year literature review found evidence that revealed long-term safety and efficacy of SCS in FBSS, CRPS, peripheral neuropathy, and severe ischemic limb pain secondary to peripheral vascular disease. (medscape.com)
- Problems with the joints, (such as arthritis), bones (such as deformities), circulation (such as peripheral vascular disease), or even pain can make it difficult to walk properly. (medlineplus.gov)
- A 62-year-old woman was seen at a clinic in the outer metro area with symptoms which indicated peripheral vascular disease. (schwebel.com)
Nerves14
- The trial wires can be removed without damaging the spinal cord or nerves. (hfmhealth.org)
- A widely used treatment modality for managing different chronic pain stages, spinal cord stimulation delivers low-level electrical signals to the spinal cord or to specific nerves to block pain signals from reaching the brain. (outsourcestrategies.com)
- Peripheral neuropathy is a set of symptoms caused by damage to the nerves that are outside the brain and spinal cord. (cancer.org)
- A neurologist is a medical doctor who specializes in diagnosing and treating diseases of the brain, spinal cord and nerves. (clevelandclinic.org)
- A neurologist is a medical doctor who diagnoses, treats and manages disorders of the brain and nervous system (brain, spinal cord and nerves). (clevelandclinic.org)
- A neurosurgeon is a medical doctor who performs surgery on the brain, spinal cord and nerves. (clevelandclinic.org)
- Neurological conditions are disorders that affect any part of your nervous system, including the brain, spinal cord, and nerves extending throughout your body. (dignityhealth.org)
- For example, a neuromuscular specialist treats diseases that affect communication between nerves and muscles, while a neuro-oncologist treats cancers that affect the nervous system. (dignityhealth.org)
- These nerves are distributed from the brain to the spinal cord, with 5 of them commencing at the spinal cord in the neck which undergo a multiple sequence of branches in the axilla, and branch out all the way through the fingertips into 3 major nerves namely the median, ulnar and the radial nerves. (mrdoctor.org)
- A small wire, also known as a lead, is placed on the back of the nerves in the spinal cord and will deliver stimulation to block chronic pain. (azaleaortho.com)
- Arachnoiditis - painful inflammation of the protective layers of the spinal nerves. (azaleaortho.com)
- Prior to the wire being placed on the back of the spinal nerves, a test trial is administered to understand if the stimulator significantly reduces your pain. (azaleaortho.com)
- The permanent leads will be placed in the epidural space behind the spinal nerves. (azaleaortho.com)
- The brain and spinal cord make up the central nervous system, while all nerves outside the central nervous system make up the peripheral nervous system. (xtremespots.com)
Multiple sclerosis6
- Chronic lesions with inflamed rims, or “smoldering” plaques, in the brains of people with multiple sclerosis (MS) have been linked to more aggressive and disabling forms of the disease. (nih.gov)
- 2. Injuries to the spinal cord or brain, or neurological diseases such as Alzheimer's disease, multiple sclerosis and Parkinson's disease. (cnn.com)
- The test can detect evidence of a brain bleed, infection, multiple sclerosis and metabolic diseases. (clevelandclinic.org)
- The test can help diagnose multiple sclerosis, acoustic neuroma and spinal cord injury. (clevelandclinic.org)
- Earlier in the year, the FDA renewed warnings about use of balloon angioplasty in neurologic disorders such as multiple sclerosis, a procedure first championed by an Italian vascular specialist and embraced by some in the MS community, although soundly rejected by most neurologists. (medpagetoday.com)
- In partnership with Translational Biosciences, a subsidiary of Medistem Panama, SCI provides clinical services for ongoing clinical trials that are assessing safety and signs of efficacy for autism, multiple sclerosis, osteoarthritis, rheumatoid arthritis, and spinal cord injury using allogeneic umbilical cord tissue-derived mesenchymal stem cells (hUC-MSC), autologous stromal vascular fraction (SVF) and hU-MSC-derived mesenchymal trophic factors (MTF). (cellmedicine.com)
Injuries5
- Current research into vascular disruption on the micro level considers the role these injuries could play in blood-brain barrier dysfunction after a head injury. (brainandspinalcord.org)
- Effective treatments for central nervous system (CNS) injuries, diseases, and disorders remain a serious challenge for preclinical research scientists and clinicians This newsletter discusses some compounds that are in clinical trials or proteins/pathways that warrant consideration as therapeutic targets (Fig. 1). (cytoskeleton.com)
- Thus, these GTPases have also received the most attention in the arena of therapeutic intervention in various CNS injuries, diseases, and disorders 1,2 . (cytoskeleton.com)
- As of February 2016, VX-210 is in Phase II/III clinical trials for treatment of acute spinal cord injuries 4-6 . (cytoskeleton.com)
- Surgery is a branch of medicine that involves treating diseases or injuries by adjusting or removing organs, tissues or bones. (eirmc.com)
Arteriovenous malformations2
- In this paper, the authors' goal was to demonstrate how these lesions, more specifically spinal cord arteriovenous malformations and dural arteriovenous fistulas, are assessed, classified, and managed at their institution. (medscape.com)
- and ARTERIOVENOUS MALFORMATIONS leading to ISCHEMIA or HEMORRHAGE into the spinal cord (hematomyelia). (bvsalud.org)
Lesions10
- Spinal cord vascular malformations are rare, fascinating lesions. (medscape.com)
- They adopt a classification based on new physiological and genetic data that treats these lesions as expressions of more complex disease processes and not simply a morphological target, with direct impact on therapeutic options. (medscape.com)
- Credit for first recognizing that spinal vascular malformations can cause SAH must be given to Heboldt in 1885 [ 28 ] and Gaupp in 1888, [ 23 ] who referred to these lesions as "hemorrhoids of the pia mater. (medscape.com)
- Vascular malformations of the spine and spinal cord are considered uncommon lesions, representing 3-16% of all spinal space-occupying lesions. (medscape.com)
- A rare genetic vascular anomaly characterized by the presence of angiomatous lesions affecting the skin, brain, and spinal cord. (orpha.net)
- Metastatic lesions are responsible for about 85% of neoplastic spinal cord compression cases, with the other 15% due to primary neoplastic lesions of the spine. (medscape.com)
- The clinical presentation in compression caused by metastatic lesions tends to be indistinguishable from that caused by primary disease. (medscape.com)
- Metastatic lesions that involve the spinal cord affect about 5-10% of patients with cancer. (medscape.com)
- 3] Approximately 15% of all primary CNS lesions arise from the spinal cord, with an estimated incidence rate of 0.5-2.5 cases per 100,000 population. (medscape.com)
- Spinal cord or nerve root lesions resulting in paraplegia or quadriplegia. (il.us)
Neurological6
- Neurological diseases and conditions can affect nearly every part of your body and affect both adults and children. (clevelandclinic.org)
- Motor neuron diseases (MNDs) are a group of progressive neurological disorders that destroy motor neurons, the cells that control skeletal muscle activity such as walking, breathing, speaking, and swallowing. (nih.gov)
- Leptomeningeal metastasis presents as multifocal neurological deficits referable to the spinal cord. (medscape.com)
- SRS ("knifeless" surgery) delivers doses of pinpointed radiation to treat neurological diseases. (healthonecares.com)
- SRS is used to treat brain tumors , trigeminal neuralgia, vascular malformations and neurological disorders, such as essential tremor. (healthonecares.com)
- TriState Neurological Surgeons, Inc. is Erie Pennsylvania's expert in treatment of Spine Disease. (tristateneurologicalsurgeons.com)
Tumors9
- This test helps diagnose spinal and spinal cord tumors and herniated disks and fractures. (clevelandclinic.org)
- This imaging test can show tumors or be used to evaluate epilepsy, brain tumors, dementia and Alzheimer's disease. (clevelandclinic.org)
- This imaging test can diagnose tumors, infections and assess the location of seizures, degenerative spine disease and stress fractures. (clevelandclinic.org)
- Infrequently, tumors may induce cavitation within the spinal cord. (medscape.com)
- Primary spinal cord tumors arise from the different elements of the central nervous system (CNS), including neurons, supporting glial cells, and meninges. (medscape.com)
- Most primary intramedullary spinal cord tumors are astrocytomas or ependymomas. (medscape.com)
- 2] Intradural extramedullary tumors-including schwannomas, neurofibromas, and meningiomas[2] -that affect the paravertebral area may spread and compress the cord through expansion. (medscape.com)
- Metastatic tumors that cause epidural cord compression and dysfunction are the most common causes of oncologic CNS injury. (medscape.com)
- This therapy uses focused radiation to treat spinal tumors, offering precision, non-invasive treatment, and potential quick recovery. (bookimed.com)
Having a spinal cord stimu2
- Many of our patients have benefited from having a spinal cord stimulator implant to decrease their chronic back, leg, or arm pain when surgery and other modalities haven't provided relief. (hfmhealth.org)
- Many of our pain patients have told us that having a spinal cord stimulator has been "life changing" for them because they have less pain. (hfmhealth.org)
Ideal Candidate for Spinal Cord Stimul1
- Who Is an Ideal Candidate for Spinal Cord Stimulation? (outsourcestrategies.com)
Chronic pain4
- Human spinal cord cell atlas provides foundation to study neurodegeneration, chronic pain, and other diseases. (nih.gov)
- Spinal cord stimulation can be used to treat a variety of diseases that result in chronic pain. (medscape.com)
- As with all other treatment options, the physician will at first evaluate or make sure whether spinal cord stimulation is the right treatment choice for managing chronic pain. (outsourcestrategies.com)
- The most common use of spinal cord stimulators is to manage or treat different types of chronic pain. (schiffmanfirm.com)
Tumor2
- For the emergency physician, however, the cell origin of the tumor is less of a concern than the consequent syndromes of spinal cord dysfunction. (medscape.com)
- Tumor diagnosis and problems of the vascular system and bones and joints are other popular applications of these scan techniques. (uclahealth.org)
Spine5
- Since then, multiple eponyms and classifications have been used for the various types of vascular malformations of the spine and spinal cord. (medscape.com)
- If a patient likes the trial and has insurance approval, a spine surgeon will implant a small generator (similar to a pacemaker) under the skin to deliver mild electrical signals to the spinal cord through a wire. (hfmhealth.org)
- Neoplastic disease that involves the spine and results in spinal cord or cauda equina compression may have devastating neurologic and functional consequences. (medscape.com)
- A spinal cord stimulator is a device that allows users to relieve pain by sending electrical impulses near their spine via a remote control. (schiffmanfirm.com)
- The number of various diseases directly or indirectly related to the state of the spine is in the tens. (ultimatehorsesites.com)
Disorders4
- This test records the electrical activity in muscles and is used to diagnose nerve and muscle disorders, spinal nerve root compression and motor neuron disorders such as amyotrophic lateral sclerosis. (clevelandclinic.org)
- Conditions that may limit breathing and trigger hypercapnia include a variety of disorders that affect the spinal cord, chest and ribcage, or metabolism. (sleepapnea.org)
- BA-1049 is being evaluated as a treatment for glaucoma and cerebral vascular disorders (e.g., cerebral cavernous malformations) 3 . (cytoskeleton.com)
- Rac1 inhibitors have been evaluated for treatment of Alzheimer's disease (AD) and neurodevelopmental disorders (e.g. (cytoskeleton.com)
Stimulator15
- Patients are evaluated for a spinal cord stimulator by reviewing their previous treatments such as medications, X-rays, MRI scans, physical therapy, injections, and surgeries. (hfmhealth.org)
- Spinal cord stimulator systems consist of three parts: pulse generator, wire with electrodes, and a remote. (hfmhealth.org)
- Typically, implanted or placed under the skin, the spinal cord stimulator (a small device similar to a pacemaker) delivers electrical pulses to the spinal cord area to mask or modify the level of pain. (outsourcestrategies.com)
- Spinal Cord Stimulator Trial - The first step is a trial period. (outsourcestrategies.com)
- Although patients with a spinal-cord stimulator used significantly less pain medication (suggesting substantial pain relief from this treatment), similar pain reduction was seen in the medical and SCS-treatment groups. (eur.nl)
- For many, a spinal cord stimulator can be a medical device that provides desperate pain relief when all previous methods have failed. (schiffmanfirm.com)
- For others, the placement of a spinal cord stimulator can bring life-changing paralysis and nerve damage if the procedure is done improperly or a defective product is used during surgery. (schiffmanfirm.com)
- If you or someone you love is a victim of medical malpractice or suffered an injury due to a spinal cord stimulator contact the team at Schiffman Firm today. (schiffmanfirm.com)
- What are some common spinal cord stimulator complications? (schiffmanfirm.com)
- No medical procedure is without risk, and this includes the implementation of a spinal cord stimulator. (schiffmanfirm.com)
- While extremely rare, the implementation of a spinal cord stimulator could potentially caus nerve damage and paralysis. (schiffmanfirm.com)
- Can I sue if I was injured by a spinal cord stimulator? (schiffmanfirm.com)
- Who is liable if I am injured by a spinal cord stimulator? (schiffmanfirm.com)
- Responsibility can be placed on a number of parties if someone is injured during a spinal cord stimulator implementation procedure, or by the device itself. (schiffmanfirm.com)
- What should I do if I am injured by a spinal cord stimulator? (schiffmanfirm.com)
Malformation2
- The first clinical description of a spinal vascular malformation was in 1890 by Berenbruch, [ 10 ] who did not recognize the lesion as a vascular entity at surgery but only later at autopsy. (medscape.com)
- Two decades later, Krause [ 32 ] recognized a spinal vascular malformation at surgery. (medscape.com)
Injury14
- Inflammation caused by an injurious stimulus of peripheral neurons and resulting in release of neuropeptides which affect vascular permeability and help initiate proinflammatory and immune reactions at the site of injury. (nih.gov)
- Can Vascular Disruption Cause Acquired Brain Injury? (brainandspinalcord.org)
- Any vascular injury or issue causing a disruption in the blood flow to the brain can lead to an acquired brain injury (ABI). (brainandspinalcord.org)
- Even a relatively minor vascular disruption acquired brain injury can continue to affect the patient as their body tries to heal. (brainandspinalcord.org)
- Vascular disruption can result in an acquired brain injury when it occurs on a massive level in a single incident, such as when someone suffers a gunshot wound to the neck. (brainandspinalcord.org)
- In many cases, we can tie a vascular disruption injury to someone else's careless or reckless behavior. (brainandspinalcord.org)
- If you or a loved one suffered a brain injury related to vascular disruption, you may be able to pursue compensation for the resulting damages. (brainandspinalcord.org)
- Brain injury , spinal cord injury or vascular malformations. (clevelandclinic.org)
- Consequent disability relates to the degree of cord impairment and anatomic level of cord injury. (medscape.com)
- If you or someone you care about was injured by a spinal cord stimulation procedure you should seek a personal injury lawsuit. (schiffmanfirm.com)
- The earlier the disease is acknowledged, the easier it is to prevent more nerve injury and reverse the course of disease with patients requiring minimal interventions. (mrdoctor.org)
- Rho activity is involved in the neuronal response to CNS trauma such as spinal cord injury. (cytoskeleton.com)
- licensed to Vertex Pharmaceuticals), is a direct-acting, cell-permeable Rho inhibitor derived from C3 transferase, designed to offer both a regenerative and neuroprotective effect after acute spinal cord injury 3,4 . (cytoskeleton.com)
- 3 rib fractures randomised to thoracic epidural (n=22) (bupivacaine, morphine or fentanyl) or systemic opioids (n=24) (morphine, hydromorphone and fentanyl) (PCA, or nurse administered if patient unable) (n=24) Excluded if had spinal injury, brain or spinal cord injury, altered mental state, unstable pelvic fracture, vascular instability. (bestbets.org)
Lesion1
- Metastatic spinal cord compression is due to invading lesion(s) in the epidural space, between the vertebral bones and the dura of the thecal sac, compressing the thecal sac, spinal cord, or cauda equina. (medscape.com)
Inflammation1
- Inflammation of the spinal cord. (nih.gov)
Ischemia3
- There has been a long history of interest in the effects of spinal cord stimulation (SCS) for critical limb ischemia (CLI), especially if meaningful revascularisation is not possible. (eur.nl)
- Neoplastic disease can cause neurologic symptoms by compression of the thecal sac, spinal cord, or cauda equina, as well as compression of the attendant vascular supply, which results in cord edema and ischemia. (medscape.com)
- Compression of the spinal cord can lead to the development of paresis, paralysis, organ dysfunction and central nervous system ischemia. (ultimatehorsesites.com)
Electrical signals to the spinal cord1
- A wire with electrodes that send electrical signals to the spinal cord. (hfmhealth.org)
Stimulators4
- Candidates for spinal cord stimulators have chronic debilitating pain for more than three months in the low back, leg, or arm and conservative therapies have failed or surgeries have failed. (hfmhealth.org)
- Neurosurgeons and doctors who specialize in pain management (an anesthesiologist or physiatrist) implant spinal cord stimulators. (outsourcestrategies.com)
- Spinal cord stimulators involve two specific procedures - to test and implant the device, and the trial and the implantation. (outsourcestrategies.com)
- While a few different types of spinal stimulators exist on the market, they are mainly composed of a single battery pack similar to a pacemaker, called the generator . (schiffmanfirm.com)
Alzheimer's5
- Alzheimer's disease and other dementias . (clevelandclinic.org)
- An estimated 285,000 individuals in Ontario currently live with some form of neurodegenerative disorder such as, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis or Lou Gehrig's disease, frontotemporal lobar degeneration, and vascular cognitive impairment. (braininstitute.ca)
- ONDRI has set out to examine both differences and similarities between neurodegenerative diseases such as: Alzheimer's disease (AD), mild cognitive impairment (MCI), Parkinson's disease (PD), vascular cognitive impairment (VCI), frontotemporal dementia (FTD), and amyotrophic lateral sclerosis (ALS). (braininstitute.ca)
- For people living with a neurodegenerative disorder such as Alzheimer's disease or dementia (estimated to be 285,000 people in Ontario alone), better care, with better outcomes, is worth a MINT. (braininstitute.ca)
- The EU Joint Programme - Neurodegenerative Disease Research (JPND) is the largest global research initiative aimed at tackling the challenge of neurodegenerative diseases, in particular, Alzheimer's. (neurodegenerationresearch.eu)
Prognosis2
- The overall mission of the Ontario Neurodegenerative Disease Research Initiative (ONDRI) is to catalyze advances in neurodegenerative disease research that improve diagnosis, prognosis, care and outcomes for Ontarians with neurodegenerative diseases and those that support them. (braininstitute.ca)
- At the same time, the most unfavorable diseases according to the prognosis of treatment are formed not only by compression of the nerve root, but also by the shift of the hernia in the direction of the spinal cord. (ultimatehorsesites.com)
Infections1
- generally caused by impairment of BILE flow, GALLSTONES in the BILIARY TRACT, infections, or other diseases. (nih.gov)
Stroke5
- In a small study, researchers used a device that stimulates the spinal cord to restore arm and hand mobility in two stroke patients, allowing them to perform daily life activities, such as using a fork to eat a meal. (nih.gov)
- Principles of Cerebrovascular Disease is logically organized by the way patients present and with an emphasis on diagnosis and management, this resource answers every possible clinical question about stroke patients. (chipsbooks.com)
- Dementia in people who have risk factors or symptoms of a stroke is often vascular dementia. (msdmanuals.com)
- While trying to maintain a safe distance from others during this time is a good idea, we cannot forget about those who are the most vulnerable, including people living with dementia, stroke or neurodegenerative diseases. (braininstitute.ca)
- Vascular problems include everything from slow circulation to stroke. (xtremespots.com)
Symptoms5
- These parents are likely to be asymptomatic (without symptoms of the disease). (nih.gov)
- Zamboni -- a vascular specialist, not a neurologist -- came up with his vascular theory of MS in 2009, hypothesizing that restricted venous outflow from the brain and spinal cord was responsible for symptoms of the disease. (medpagetoday.com)
- Do you have symptoms of a spinal hernia? (ultimatehorsesites.com)
- Clinical manifestations of symptoms of spinal hernia depend on the location, size and direction of the hernia. (ultimatehorsesites.com)
- The symptoms of these diseases are familiar to many, and they are not only pain in the back of the various intensity and frequency. (ultimatehorsesites.com)
Clinical4
- This Funding Opportunity Announcement (FOA) seeks to accelerate the pace and expand the breadth of scientific research on the clinical course, prevention and treatment of diseases within NHLBI's mission by leveraging ongoing clinical research studies through ancillary studies. (nih.gov)
- This page features extramurally funded clinical trials supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). (nih.gov)
- In 2014, Translation Biosciences expects to expand its clinical trial portfolio to include heart disease and cerebral palsy. (cellmedicine.com)
- Yet there are very few longitudinal studies comparing detailed clinical, physiological and brain imaging features across diseases to look for similarities, differences and targets for intervention. (braininstitute.ca)
Diagnosis4
- Therefore, it is critical to consult with specialists in neurology and infectious diseases for appropriate diagnosis and management. (snohd.org)
- Unresponsive otitis media and conditions, essentials of diagnosis & typical features infants with moderate stenosis are at risk include those with persistent systemic disease such as stevens-johnson syndrome anticonvulsants nonsteroidal anti-inflammatory agents have been identified in a neonate. (elastizell.com)
- DESCRIPTION (provided by applicant): Understanding why disease progression in the majority of patients with Amyotrophic Lateral Sclerosis (ALS) occurs in contiguous anatomic regions over time is one of the fundamental limitations to designing disease modifying therapies that can be utilized after a diagnosis. (neurodegenerationresearch.eu)
- These studies will occur with an eye towards the potential for translating what is learned about Cx43-mediated astrocytic influences on disease progression and spread to the development of potential pharmacological strategies for intervention after an ALS diagnosis. (neurodegenerationresearch.eu)
Amyotrophic lateral s4
- a public-private partnership aimed at advancing the understanding of neurodegenerative diseases and fostering the development of treatments for amyotrophic lateral sclerosis (ALS) and other rare neurodegenerative diseases. (nih.gov)
- Amyotrophic lateral sclerosis (also called ALS or Lou Gehrig's disease). (clevelandclinic.org)
- This group includes diseases such as amyotrophic lateral sclerosis, progressive bulbar palsy, primary lateral sclerosis, progressive muscular atrophy, spinal muscular atrophy, Kennedy's disease, and post-polio syndrome. (nih.gov)
- Amyotrophic lateral sclerosis (ALS) , also known as classical motor neuron disease, affects both the upper and lower motor neurons. (nih.gov)
Blood vessels3
- 1. Vascular diseases and diabetes, which affect the proper functioning of blood vessels. (cnn.com)
- CAA is caused by accumulation of beta-amyloid (an abnormal protein) in blood vessels in brain, Most people with Alzheimer disease have CAA, but it also occurs in the brains of many healthy older people. (msdmanuals.com)
- Pathological processes involving any of the BLOOD VESSELS feeding the SPINAL CORD , such as the anterior and paired posterior spinal arteries or their many branches. (bvsalud.org)
Metabolic1
- Connexins in astrocytes have key roles: homeostatic buffering, synchronization of astrocyte networks, metabolic support for neurons, and regulation of vascular physiology. (neurodegenerationresearch.eu)
Trauma2
- Additionally, vascular disruption can occur over time when repeated trauma damages the small vessels of the brain. (brainandspinalcord.org)
- Other trauma-related causes include resulting in posterior migration of fragments of the vertebral body, spinal anesthesia involving trauma from catheters and high local anesthetic concentrations around the cauda equina. (tristateneurologicalsurgeons.com)
Cognitive2
- Subcortical ischemic vascular cognitive impairment and dementia: Dementia results from tissue damage in the area of the brain under the cortex (the convoluted outer surface of the cerebrum, which is the largest part of the brain). (msdmanuals.com)
- Importantly, neurodegenerative brain changes are also frequently associated with vascular disease of the brain (vascular cognitive impairment [VCI]), making mixed disease common in the aging population. (braininstitute.ca)
Parkinson's1
- Several neurodegenerative diseases cause dementia, with the most common being Alzheimer`s disease (AD) followed by Parkinson's-Lewy body disease (PD-LBD). (braininstitute.ca)
Cauda equina1
- The nerve roots within the lumbar canal find their origin in the termination of the spinal cord and collectively are termed the cauda equina. (tristateneurologicalsurgeons.com)
Human spinal1
- Our preliminary data show that Cx43 is upregulated in ALS models as well as in human spinal cord and cortex in patients with ALS. (neurodegenerationresearch.eu)
Stenosis1
- Chronic leg (sciatica) or arm pain - ongoing pain caused by spinal stenosis, arthritis, or a damaged nerve. (azaleaortho.com)
Types of vascular1
- Other types of vascular dementias are less common. (msdmanuals.com)
Posterior1
- The neural tracts most vulnerable to mechanical pressure include the corticospinal and spinocerebellar tracts and the posterior spinal columns. (medscape.com)
Fistulas2
- and the arteriovenous type, consisting of a fistulous capillary bed, preferentially located in the cervical enlargement anteriorly or at the lumbar enlargement, indicating for the first time that true medullary AVMs are different from what we know today as spinal dural fistulas. (medscape.com)
- Cite this: Spinal Cord Vascular Shunts: Spinal Cord Vascular Malformations and Dural Arteriovenous Fistulas - Medscape - Jan 01, 2009. (medscape.com)
Surgeries2
- They also typically have had one or more spinal surgeries. (outsourcestrategies.com)
- HealthONE's movement disorder specialists use advanced technologies, medications and surgeries to help treat and manage tremors, involuntary muscle contractions and associated diseases. (healthonecares.com)
Compression4
- Metastatic spinal cord compression usually follows arterial hematogenous dissemination of malignant cells to the vertebral bodies, with subsequent expansion into the epidural space. (medscape.com)
- Principles of treating intramedullary cancer are similar to those for epidural spinal cord compression. (medscape.com)
- That's why the use of analgesic, anti-inflammatory, vascular and even chondroprotective drugs without the elimination of compression (irritation) of the nerve has no long-term and effective therapeutic effect. (ultimatehorsesites.com)
- There are states when to cope with hernia and eliminate compression of the spinal cord or nerve root can only be methods of surgical intervention. (ultimatehorsesites.com)
Renal1
- Impaired renal function due to chronic renal disease (documented by persistent adverse objective findings) resulting in severely reduced function that may require dialysis or kidney transplant. (il.us)
Nervous system2
- The spinal cord is responsible for the interrelation of the central nervous system with all organs, regulating the functions of the entire body and the functioning of the musculoskeletal system. (ultimatehorsesites.com)
- Emission is triggered by the autonomic nervous system , specifically by fibers that originate between the lower thoracic (T10-12) and upper lumbar (L1 and 2) segments of the spinal cord. (harvard.edu)
Cervical1
- Cervical spondylosis - This condition is characterized by the degeneration of intervertebral disks in the neck area of the spinal column. (mrdoctor.org)
Motor neuron2
Epidural1
- Connected to the generator is a series of thin wires, or electrodes , that are placed between the spinal cord and vertebrae, known as the epidural space. (schiffmanfirm.com)
Treat2
- What diseases and conditions does a neurologist treat? (clevelandclinic.org)
- Vascular surgery involves procedures that treat conditions affecting the arteries, veins and lymphatic systems. (eirmc.com)
Centers for Diseas4
- The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
- The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
- Read Carefully before Using The Public Health Service Act (Section 308 (d)) provides that the data collected by the National Center for Health Statistics (NCHS), Centers for Disease Control and Prevention (CDC), may be used only for the purpose of health statistical reporting and analysis. (cdc.gov)
- The NAMCS is a national probability sample survey conducted by the Division of Health Care Statistics, National Center for Health Statistics (NCHS), Centers for Disease Control and Prevention (CDC). (cdc.gov)
Metastases1
- Metastases to the substance of the cord (intramedullary) are relatively rare. (medscape.com)
Cerebrovascular Disease2
- Principles of Cerebrovascular Disease, by Harold P. Adams, Jr. (chipsbooks.com)
- Cerebrovascular Disease book from C.H.I.P.S. (chipsbooks.com)
Procedure1
- Based on these evaluations, we may decide that a spinal cord procedure is right for you. (azaleaortho.com)