Insufficiency of arterial or venous blood supply to the spleen due to emboli, thrombi, vascular torsion, or pressure that produces a macroscopic area of necrosis. (From Stedman, 25th ed)
The largest branch of the celiac trunk with distribution to the spleen, pancreas, stomach and greater omentum.
Surgical procedure involving either partial or entire removal of the spleen.
The condition of being heterozygous for hemoglobin S.

Dermatomyositis with splenic and renal infarctions during corticosteroid therapy. (1/41)

A 60-year-old woman was admitted to our hospital with complaints of muscle weakness and erythema on her extremities. Gottron's sign, heliotrope rash, elevation of serum myogenic enzymes, electromyography and magnetic resonance imaging findings established a diagnosis of dermatomyositis (DM). She was treated with 60 mg of daily prednisolone. One week later, she suddenly developed splenic and renal infarctions, which were considered to have resulted from vasculopathy associated with DM. Cyclophosphamide and anticoagulants along with increasing the dosage of corticosteroid were effective. This is the first report describing splenic and renal infarctions in a patient with adult-onset DM.  (+info)

Thermophilic multidrug-resistant Campylobacter fetus infection with hypersplenism and histiocytic phagocytosis in a patient with acquired immunodeficiency syndrome. (2/41)

We present a case report of a patient who had acquired immunodeficiency syndrome (AIDS) and Campylobacter fetus infection with a number of unusual clinical and microbiological features. The patient had prominent gastrointestinal symptoms, splenic infarction, splenomegaly with hypersplenism, and hemophagocytic histiocytosis in the spleen and lymph nodes; the organism displayed growth on Campy-selective blood agar, thermotolerance, and resistance to quinolones, piperacillin/tazobactam, ceftazidime, and erythromycin.  (+info)

Acute cytomegalovirus infection complicated by vascular thrombosis: a case report. (3/41)

We present a case report of a previously healthy adult with cytomegalovirus infection that was complicated by extensive mesenteric arterial and venous thrombosis. To our knowledge, this is the first reported case of this syndrome in an immunocompetent individual who had no predisposing risk factors for thrombosis, and it demonstrates the propensity for cytomegalovirus to be involved in vascular disease.  (+info)

Splenic accumulation of 99mTc-diphosphonate in a patient with sickle cell disease: case report. (4/41)

Splenic accumulation of 99mTc-diphosphonate is shown in the bone scan of a patient with sickle cell disease. This uptake is assumed to result from splenic infarction and subsequent calcification. The conventional liver-spleen scan with 99mTc-sulfur colloid shows no splenic activity, and a radiograph shows calcification in the left upper quadrant of the abdomen in the expected anatomic location of the spleen.  (+info)

Asian variant of CD5+ intravascular large B-cell lymphoma with splenic infarction. (5/41)

A 57-year-old man was admitted with fever and epigastralgia, and presented with splenomegaly and pancytopenia. A CT scan revealed splenic infarctions. There were no lymphadenopathies, skin lesions, or neurological abnormalities. A splenectomy was performed. Bone marrow involvement with hemophagocytosis was noted. The diagnosis of Asian variant of intravascular diffuse large B-cell lymphoma was based on intravascular and sinusoidal distribution of large CD5+ B cells. The patient died of the disease 11 months after onset. To our knowledge, this is the first report of AIVL that presented with splenic infarction. This distinct lymphoma should be included in the differential diagnosis of splenic infarction.  (+info)

Splenic infarction following laparoscopic Nissen fundoplication: management strategies. (6/41)

Techniques for mobilizing the greater curve of the stomach during laparoscopic Nissen fundoplication (LNF) include division of the short gastric vessels (SGV). The splenic artery and vein lie directly posterior to the proper plane of dissection. Uncontrolled bleeding during SGV division places the splenic vessels at risk for inadvertent injury or ligation. We report herein on 2 patients referred to our institution who had left upper quadrant pain and radiographic evidence of segmental splenic infarction (SI) that resulted from a peripheral splenic artery branch injury during LNF. Management strategies included a trial of conservative management and splenectomy for persistent symptoms or complications resulting from SI. Intense inflammation and adhesion formation making laparoscopic splenectomy difficult should be anticipated when operating on the infarcted spleen.  (+info)

Torted and ruptured wandering spleen presenting as a surgical emergency in pregnancy. (7/41)

Wandering spleen (WS) is characterised by incomplete fixation of the spleen to its supporting linorenal and gastrosplenic ligaments. It can predispose to life-threatening complications due to torsion of its vascular pedicle, splenic infarction, portal hypertension, and haemorrhage. A 27-year-old, 36-week prima gravida underwent emergency caesarean section for tachycardia and hypotension. A healthy baby girl was delivered. However, she remained shocked despite aggressive fluid therapy and intraoperatively it was noted that there was significant intraperitoneal bleeding and the on-call surgical team was summoned. Midline laparotomy revealed a lacerated, infarcted, hypermobile spleen found with free intraperitoneal bleeding. The unsalvageable spleen was resected and the patient went on to make an excellent recovery. The aetiology of WS is contentious. With an increased frequency among multiparous females of reproductive age, some suggest the hormonal effects of pregnancy as contributing factors. Clinical presentations range from an asymptomatic abdominal mass to acute abdominal pain with hypovolaemic shock. WS poses a serious threat to life due to thrombosis, bleeding, or infarction. Ultrasound scan and CT scan are equally effective in the diagnosis. Patients with asymptomatic WS should be treated with elective splenopexy, however, in the acute presentation, splenectomy is the procedure of choice.  (+info)

Splenic syndrome in patients at high altitude with unrecognized sickle cell trait: splenectomy is often unnecessary. (8/41)

BACKGROUND: The health risks associated with sickle cell trait are minimal in this sizable sector of the world's population, and many of these patients have no information about their sickle cell status. Splenic syndrome at high altitude is well known to be associated with sickle cell trait, and unless this complication is kept in mind these patients may be subjected to unnecessary surgery when they present with altitude-induced acute abdomen. METHODS: Four patients were admitted to the surgical ward with a similar complaint of acute severe left upper abdominal pain after arrival to the mountainous resort city of Abha, Saudi Arabia. All were subjected to splenectomy because of lack of suspicion regarding sickle cell status. RESULTS: Histologic examination of the spleen showed all patients had sickle cells in the red pulp. On further assessment all were found to have sickle cell trait with splenic infarction. In a similar study of 6 patients with known sickle cell disease who had comparable problems when they travelled to the Colorado mountains, all made an uncomplicated recovery with conservative management. CONCLUSIONS: In ethnically vulnerable patients with splenic syndrome, sickle cell trait should be ruled out before considering splenectomy. These patients could respond well to supportive management, and splenectomy would be avoided.  (+info)

Splenic infarction is the death of splenic tissue due to blockage of its arterial supply or, less commonly, its venous drainage. This results in ischemia and necrosis of the affected portion of the spleen. The most common cause is embolism from a distant source such as atrial fibrillation, infective endocarditis, or malignancy. Other causes include splenic artery thrombosis, sickle cell disease, hematologic disorders, and trauma. Clinical presentation can vary widely, ranging from being asymptomatic to acute abdominal pain, nausea, vomiting, and fever. Diagnosis is often made with imaging studies such as ultrasound or CT scan. Treatment depends on the underlying cause and severity of symptoms, but may include anticoagulation, antibiotics, or surgical intervention in severe cases.

The splenic artery is the largest branch of the celiac trunk, which arises from the abdominal aorta. It supplies blood to the spleen and several other organs in the upper left part of the abdomen. The splenic artery divides into several branches that ultimately form a network of capillaries within the spleen. These capillaries converge to form the main venous outflow, the splenic vein, which drains into the hepatic portal vein.

The splenic artery is a vital structure in the human body, and any damage or blockage can lead to serious complications, including splenic infarction (reduced blood flow to the spleen) or splenic rupture (a surgical emergency that can be life-threatening).

A splenectomy is a surgical procedure in which the spleen is removed from the body. The spleen is an organ located in the upper left quadrant of the abdomen, near the stomach and behind the ribs. It plays several important roles in the body, including fighting certain types of infections, removing old or damaged red blood cells from the circulation, and storing platelets and white blood cells.

There are several reasons why a splenectomy may be necessary, including:

* Trauma to the spleen that cannot be repaired
* Certain types of cancer, such as Hodgkin's lymphoma or non-Hodgkin's lymphoma
* Sickle cell disease, which can cause the spleen to enlarge and become damaged
* A ruptured spleen, which can be life-threatening if not treated promptly
* Certain blood disorders, such as idiopathic thrombocytopenic purpura (ITP) or hemolytic anemia

A splenectomy is typically performed under general anesthesia and may be done using open surgery or laparoscopically. After the spleen is removed, the incision(s) are closed with sutures or staples. Recovery time varies depending on the individual and the type of surgery performed, but most people are able to return to their normal activities within a few weeks.

It's important to note that following a splenectomy, individuals may be at increased risk for certain types of infections, so it's recommended that they receive vaccinations to help protect against these infections. They should also seek medical attention promptly if they develop fever, chills, or other signs of infection.

Sickle cell trait is a genetic condition where an individual inherits one abnormal gene for hemoglobin S (HbS) from one parent and one normal gene for hemoglobin A (HbA) from the other parent. Hemoglobin is a protein in red blood cells that carries oxygen throughout the body.

People with sickle cell trait do not have sickle cell disease, but they can pass the abnormal HbS gene on to their children. In certain situations, such as high altitude, low oxygen levels, or intense physical exertion, individuals with sickle cell trait may experience symptoms similar to those of sickle cell disease, such as fatigue, pain, and shortness of breath. However, these symptoms are typically milder and less frequent than in people with sickle cell disease.

It is important for individuals who know they have sickle cell trait to inform their healthcare providers, especially if they become pregnant or plan to engage in activities that may cause low oxygen levels, such as scuba diving or high-altitude climbing.

... occurs when the splenic artery or one of its branches are occluded, for example by a blood clot. In one ... Splenic infarction can be induced for the treatment of such conditions as portal hypertension or splenic injury. It can also be ... Splenic infarction is a condition in which blood flow supply to the spleen is compromised, leading to partial or complete ... Splenic infarction can also result from a sickle cell crisis in patients with sickle cell anemia. Both splenomegaly and a ...
Lung: Pulmonary infarction or lung infarction Spleen: Splenic infarction occurs when the splenic artery or one of its branches ... Limb: Limb infarction is an infarction of an arm or leg. Causes include arterial embolisms and skeletal muscle infarction as a ... Heart: Myocardial infarction (MI), commonly known as a heart attack, is an infarction of the heart, causing some heart cells to ... Infarctions are divided into two types according to the amount of blood present: White infarctions (anemic infarcts) affect ...
"Primary antiphospholipid syndrome presenting with abdominal angina and splenic infarction". Rheumatol. Int. 22 (3): 119-21. doi ...
Ultrasound findings of the hypoechoic wedge-shaped region of splenic tissue indicate infarction. Evolution of infarction may ... may be found in splenic infarction. However, these results lack specificity to splenic infarct. Radiographic testing is ... Ami, S; Meital, A; Ella, K; Abraham, K (2015-09-11). "Acute Splenic Infarction at an Academic General Hospital Over 10 Years: ... Splenic infarct appears as a wedge-shaped area of splenic tissue with the apex pointed toward the helium and the base of the ...
Splenic infarction occurs when the splenic artery or one of its branches are occluded, for example by a blood clot. Although it ... Splenic infarction is a condition in which blood flow supply to the spleen is compromised, leading to partial or complete ... Nores, M1; Phillips, EH; Morgenstern, L; Hiatt, JR (February 1998). "The Clinical Spectrum of Splenic Infarction". The American ... which is the point of attachment for the gastrosplenic ligament and the point of insertion for the splenic artery and splenic ...
Asplenia Hepatosplenomegaly Portal hypertension Sign (medicine) Splenic aspiration Splenic infarction Tropical splenomegaly ... Rosenberg, H K; Markowitz, R I; Kolberg, H; Park, C; Hubbard, A; Bellah, R D (1991). "Normal splenic size in infants and ... Signs of splenomegaly may include a palpable left upper quadrant abdominal mass or splenic rub. It can be detected on physical ... The most common causes of splenomegaly in developed countries are infectious mononucleosis, splenic infiltration with cancer ...
Other infrequent side effects include splenic infarction, bowel obstruction, paralytic ileus, and upper GI bleeding. ...
... s have also been demonstrated to be released into the blood from a splenic reserve following myocardial infarction. ... February 2020). "Diagnosis of myocardial infarction at autopsy: AECVP reappraisal in the light of the current clinical ... "Absolute neutrophil counts and fibrinogen levels as an aid in the early diagnosis of acute myocardial infarction". Acta ... "Neutrophils incite and macrophages avert electrical storm after myocardial infarction". Nature Cardiovascular Research. 1 (7): ...
Swine fever causes fever, skin lesions, convulsions, splenic infarctions and usually (particularly in young animals) death ...
Abdominal pain due to hypersplenism, splenic infarction and right-upper quadrant pain caused by gallstones are major clinical ...
... (splenoptosis) predisposes the spleen to complications such as torsion, splenic infarction, pancreatic ... M, Noushif (Jul 2011). "Splenic pseudocyst: a rare association with splenoptosis and vertebral segmentation anomalies". ...
It turned out that Clark had had a splenic infarction due to the sickle cell trait which he has had since he was a child; these ...
"E-Selectin Inhibition Mitigates Splenic HSC Activation and Myelopoiesis in Hypercholesterolemic Mice With Myocardial Infarction ... Splenic macrophages and adhesion molecules may be involved in regulation of extramedullary myeloid cell generation in ... "Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites". Science. 325 (5940): 612-616. ...
Spermatocele Sphenoid wing meningioma Spider angioma Splenic infarction (though not typically) Subarachnoid hemorrhage ...
... splenic infarction MeSH C15.604.744.680 - splenic neoplasms MeSH C15.604.744.742 - splenic rupture MeSH C15.604.744.742.500 - ... splenosis MeSH C15.604.744.909 - tuberculosis, splenic MeSH C15.604.744.954 - wandering spleen MeSH C15.604.921.500 - king's ...
Splenic torsion, causing splenic infarction Ovarian torsion Testicular torsion Penile torsion, a congenital condition Torsion ...
... splenic infarction MeSH C14.907.553.470 - myocardial ischemia MeSH C14.907.553.470.250 - coronary disease MeSH C14.907.553.470. ... infarction MeSH C14.907.553.355.249 - brain infarction MeSH C14.907.553.355.249.100 - brain stem infarctions MeSH C14.907. ... brain infarction MeSH C14.907.253.480.200.100 - brain stem infarctions MeSH C14.907.253.480.200.100.500 - lateral medullary ... infarction, anterior cerebral artery MeSH C14.907.253.337.562 - infarction, middle cerebral artery MeSH C14.907.253.337.656 - ...
... splenic artery pseudoaneurysms, hemorrhage from erosions into splenic artery and vein, thrombosis of the splenic vein, superior ... infarction, cholecystitis, and a perforated ulcer. If the lipase level is about 2.5 to 3 times that of amylase, it is an ... secondary to splenic vein thrombosis) Gastrointestinal obstruction Hepatobiliary Jaundice Portal vein thrombosis Neurologic ... Perforated peptic ulcer Biliary colic Acute cholecystitis Pneumonia Pleuritic pain Myocardial infarction Elevated serum amylase ...
Treated either by particle infarction or transcatheter arterial chemoembolization (TACE). Uterine fibroids Arteriovenous ... bleeding Nosebleed Varicocele Primary post-partum bleeding Surgical bleeding Traumatic bleeding such as splenic rupture or ...
Ectopic splenic tissue was first described in 1896 by Albrecht in Germany, whereas the term "splenosis" was first used by ... Tissue infarction due to limited blood supply can be a cause of symptomatic splenosis. Symptoms of splenosis affecting the ... Multiple implants of splenic tissue can mimic the appearance of some cancerous conditions. This can be clarified through ... Due to the limited blood supply to these nodules, the typical size of splenic implants is usually less than 3 cm. The implants ...
Secondary peritonitis and intra-abdominal abscesses including splenic and hepatic abscesses generally occur because of the ... infarction or direct trauma. Perforated appendicitis, diverticulitis, inflammatory bowel disease with perforation and ...
Hypoperfusion in watershed areas can lead to mural and mucosal infarction in the case of ischemic bowel disease. When watershed ... such as the splenic flexure of the large intestine. The term refers metaphorically to a geological watershed, or drainage ... splenic flexure). Additionally, the sigmoid colon and rectum form a watershed zone with blood supply from inferior mesenteric, ...
Examples of an end artery include the splenic artery that supplies the spleen and the renal artery that supplies the kidneys. ... leading to a myocardial infarction or an ischaemic stroke. Other end arteries supply all or parts of the liver, intestines, ...
Smerud M, Johnson C, Stephens D (1990). "Diagnosis of bowel infarction: a comparison of plain films and CT scans in 23 cases". ... such as the splenic flexure and the rectosigmoid junction. These watershed areas are most vulnerable to ischemia when blood ... In the most severe cases, transmural infarction with resulting perforation may be seen; after recovery, the muscularis propria ... Commonly the embolism is caused by atrial fibrillation, valvular disease, myocardial infarction, or cardiomyopathy.[citation ...
Typically, treatment involves removal of the region of the bowel that has undergone infarction, and subsequent anastomosis of ... the splenic flexure, or the junction between the transverse and descending colon, is supplied by the most distal portions of ...
It initially travels in an anterior/inferior direction, passing behind/under the neck of the pancreas and the splenic vein. ... a predictor of ischemic injury in acute mesenteric infarction". Digestive Surgery. 15 (1): 55-9. doi:10.1159/000018587. ISSN ...
Splenic artery pseudoaneurysms, for example, may develop as a result of pancreatitis. In some cases, pseudoaneurysms of the ... Coronary ischemia results in myocardial infarction, also known as a heart attack. The coronary arteries were one of the ...
Disseminated HS (including MH) is not readily treated surgically, since even in the splenic form, early metastasis to the liver ... The histiocytes frequently invade vessel walls and this may lead to vascular compromise and infarction of surrounding tissues. ... Secondary sites are widespread, but consistently include liver and lung (with splenic primary), and hilar lymph node (with lung ...
For people with pre-existing cardiovascular disease, the additional workload can result in myocardial infarction and/or acute ... and vascular splenic contraction. Early models of cold water immersion syndrome focused primarily on sympathetic responses, ...
Splenic sequestration crises are acute, painful enlargements of the spleen, caused by intrasplenic trapping of red cells and ... Cerebral infarction occurs in children and cerebral haemorrhage in adults.[citation needed] Silent stroke causes no immediate ... Decreased immune reactions due to hyposplenism (malfunctioning of the spleen) Priapism and infarction of the penis ... splenic sequestration crisis, haemolytic crisis, and others. Most episodes of sickle cell crises last between five and seven ...
Splenic infarction occurs when the splenic artery or one of its branches are occluded, for example by a blood clot. In one ... Splenic infarction can be induced for the treatment of such conditions as portal hypertension or splenic injury. It can also be ... Splenic infarction is a condition in which blood flow supply to the spleen is compromised, leading to partial or complete ... Splenic infarction can also result from a sickle cell crisis in patients with sickle cell anemia. Both splenomegaly and a ...
Splenic infarction is the death of tissue (necrosis) in the spleen due to a blockage in blood flow. ... Splenic infarction is the death of tissue (necrosis) in the spleen due to a blockage in blood flow. ... Splenic infarction is the death of tissue (necrosis) in the spleen due to a blockage in blood flow. ...
Splenic infarction}} ==References== {{r.... Retrieved from "https://www.wikidoc.org/index.php/Splenic_infarction_future_or_ ... Splenic infarction future or investigational therapies: Revision history. View logs for this page ...
Case 18: post-meningococcal splenic infarctionCase 18: post-meningococcal splenic infarction ... global splenic infarction, entire spleen is hypoenhancing, e.g. in splenic torsion ... Splenic infarction is a result of ischemia to the spleen, and in many cases requires no treatment. However, identification of ... The appearance of splenic infarction depends on the timing of imaging and the size of the infarct. Although once the infarct ...
... in conjunction with the intravenous administration of contrast material to maximize density differences between the splenic ... Splenic infarction. Causes of splenic infarction include the following:. * Embolic - Endocarditis, atherosclerotic plaque, ... Splenic abscesses caused by bacterial endocarditis, splenic infarction, and invasive procedures can simulate splenic injury, ... A patient who has significant or total splenic volume infarction after SAE requires close observation for the development of ...
ENDOTHELIUM-DERIVED EXTRACELLULAR VESICLES PROMOTE SPLENIC MONOCYTE MOBILISATION IN MYOCARDIAL INFARCTION Akbar N., Digby JE., ... Targeting cardiac inflammation in post-infarction myocardial injury using novel chemokine-ligand traps derived from tick saliva ...
Infectious Mononucleosis-Induced Splenic Infarction: Perhaps More Common in Healthy Individuals Than Previously Thought. ... Mamo G, Erickson S, Komanduri K, Zayas D, Aggarwal N. Infectious Mononucleosis-Induced Splenic Infarction: Perhaps More Common ... coagulopathy, ebv, epstein-barr virus, infarction, infectious disease, infectious mononucleosis, internal medicine, monospot, ...
ENDOTHELIUM-DERIVED EXTRACELLULAR VESICLES PROMOTE SPLENIC MONOCYTE MOBILISATION IN MYOCARDIAL INFARCTION Akbar N., Digby JE., ...
This report discusses a case of splenic abscess complicating an infarction in a teenager at the Teaching Hospital of Borgou/ ... Abdominal ultrasound and thoraco-abdominal CT-scan revealed a splenic infarction abscess. Following medical treatment, which ... Conclusion: Splenic abscess should be suspected in any subject with sickle cell disease presenting with painful and febrile ... Massive Splenic Infarction Abscess in A Teenager with Sickle Cell Disease: A Case Report in Northern Benin , Abstract. Asploro ...
Splenic infarction and malaria. Norman FF, Rojas-Marcos J, Hermida-Donate JM, Monge-Maillo B, Perez-Molina JA, López-Vélez R. ...
Splenic infarction refers to occlusion of the splenic vascular supply, leading to parenchymal ischemia and subsequent tissue ... Splenic infarction complicated by splenic artery occlusion after N-butyl-2-cyanoacrylate injection for gastric varices: case ... Splenic infarct. Selective splenic arteriogram showing extravasation of contrast from the splenic artery at the splenic hilum ... Splenic infarction: sonographic patterns, diagnosis, follow-up, and complications. Radiology. 1990 Mar. 174 (3 Pt 1):803-7. [ ...
PR3 vasculitis presenting with symptomatic splenic and renal infarction: a case report and literature review Share Share Share ... PR3 vasculitis presenting with symptomatic splenic and renal infarction: a case report and literature review ...
A computed tomography scan confirmed right-sided partial renal and splenic infarctions likely due to spreading emboli from ... CONCLUSIONS:Acute renal infarction is often missed or delayed as a diagnosis because patients often present with flank pain ... Renal infarction should be considered in cases with acute flank pain accompanied by (low-grade) fever, high LDH level, ... CASE REPORT:A 47-year-old male with a history of familial hypercholesterolemia and cerebral infarction presented at the ...
Group B Streptococcal Tricuspid Valve Endocarditis with Splenic Infarction after an Elective Abortion. DOI: 10.7727/wimj. ... Read more about Group B Streptococcal Tricuspid Valve Endocarditis with Splenic Infarction after an Elective Abortion ...
Spleen infarction is rarer than rupture and may go unnoticed. Only 9 documented cases of splenic infarction associated with ... or infarction (1-3). Hematoma or infarction of the spleen might be followed by the development of a splenic abscess, a clinical ... Splenic infarction during acute malaria. Trans R Soc Trop Med Hyg. 2005;99:82-6. DOIPubMedGoogle Scholar ... Indeed, splenic hematoma or infarction, together with the humoral and cellular immunodepression due to malaria, might well be ...
An 83-year-old woman with a history of hypertension, diabetes and paroxysmal atrial fibrillation anticoagulated with acenocoumarol was brought to the emergency department due to dyspnoea. At admission, the patient reported a 1-week history of malaise, shortness of breath and non-productive cough. She denied fever but reported pain on the left flank. On examination, auscultation showed arrhythmic tones and crackles in the left lower lung field. Laboratory findings showed leucocytosis of 15.32×103/μL, and the C reactive protein was 177 mg/L. The activated partial thromboplastin time was 54.8 s, and the international normalised ratio was 7.09. A chest X-ray showed left lower lobe consolidation with pleural effusion. Point-of-care ultrasound was performed using a low-frequency curved transducer (2-5 MHz). The probe was placed in the left posterior axillary showing a pulmonary consolidation, but also a hypoechoic lesion in the spleen was found (figure 1). ...
... enzyme inhibition prevents the release of monocytes from their splenic reservoir in mice with myocardial infarction. Circ. Res. ... CC chemokine CCL5 plays a central role impacting infarct size and post-infarction heart failure in mice. Eur. Heart J. 33, 1964 ... Our findings are broadly in line with recent scRNA-seq analyses of cardiac macrophages in myocardial infarction33, DCM51, TAC52 ... Iyer, R. P., Jung, M. & Lindsey, M. L. MMP-9 signaling in the left ventricle following myocardial infarction. Am. J. Physiol. ...
Previous Gastrointestinal or Splenic infarction. *Ischaemic Colitis. *Allergy or sensitivity to antibiotics called ...
Splenic infarction 22996003. *Traction injury of spleen 446121009. *Transection of adrenal gland 262835000 ...
We retrospectively evaluated the long-term effects of partial splenic embolization (PSE) with transarterial chemoembolization ( ... Dynamic CT was performed in all patients 1 week after the procedure to confirm the area of splenic infarction. When a patient ... Calculation of Splenic Volume and Noninfarcted Splenic Volume. Splenic and noninfarcted splenic volumes in each patient were ... Mean splenic volume before PSE was mL. The mean platelet count before treatment was × 104/mL. Seventeen patients showed an ...
Swine fever causes fever, skin lesions, convulsions, Splenic Infarctions and usually (particularly in young animals) death ...
... presented a patient with Hb SC disease with an excellent baseline functional status who developed splenic infarction at a high ...
In this case, an ideal extent of the splenic infarction was successfully achieved using a small number of coils. This is the ... The subjects included patients ≥16 years of age who were hospitalized with pneumonia or cerebral infarction and treated by a ... A 52-year-old man underwent partial splenic embolization (PSE) for hypersplenism. The intrasplenic artery targeted for the ... Acute aortic syndrome complicated by both ST-segment elevation myocardial infarction (STEMI) and spinal ischemia is exceedingly ...
Splenic Infarction Medicine & Life Sciences 51% * Transesophageal Echocardiography Medicine & Life Sciences 37% ... N2 - We report the case of splenic infarct secondary to embolisation from a polypoid 17 mm x 10 mm thoracic aorta thrombi in a ... AB - We report the case of splenic infarct secondary to embolisation from a polypoid 17 mm x 10 mm thoracic aorta thrombi in a ... We report the case of splenic infarct secondary to embolisation from a polypoid 17 mm x 10 mm thoracic aorta thrombi in a 60 ...
... gastrointestinal vascular ischemia and infarction (presenting with abdominal pain and bloody diarrhea), splenic infarction, and ... including myocardial infarction and stroke, which can be fatal. This risk may occur early in treatment and may increase with ... There have been rare reports of serious cardiac adverse reactions, including acute myocardial infarction, occurring within a ... Advise patients to be alert for the symptoms of cardiovascular thrombotic effects such as myocardial infarction or stroke, ...
... gastrointestinal vascular ischemia and infarction (presenting with abdominal pain and bloody diarrhea), splenic infarction, and ... Advise patients to be alert for the symptoms of cardiovascular thrombotic effects such as myocardial infarction or stroke, ... There have been rare reports of serious cardiac adverse reactions, including acute myocardial infarction, occurring within a ... Ischemic coronary artery disease (CAD) (angina pectoris, history of myocardial infarction, or documented silent ischemia) or ...
... gastrointestinal vascular ischemia and infarction (presenting with abdominal pain and bloody diarrhea), splenic infarction, and ... 5.1 Myocardial Ischemia, Myocardial Infarction, and Prinzmetals Angina 5.2 Arrhythmias 5.3 Chest, Throat, Neck, and/or Jaw ... Myocardial ischemia/infarction and Prinzmetals angina: Perform cardiac evaluation in patients with multiple cardiovascular ... Myocardial ischemia, myocardial infarction, and Prinzmetals angina [see Warnings and Precautions (5.1)] ...
Splenic infarction refers to occlusion of the splenic vascular supply, leading to parenchymal ischemia and subsequent tissue ... Splenic infarction refers to occlusion of the splenic vascular supply, leading to parenchymal ischemia and subsequent tissue ... Splenic infarct. Selective splenic arteriogram showing extravasation of contrast from the splenic artery at the splenic hilum ... Splenic infarction complicated by splenic artery occlusion after N-butyl-2-cyanoacrylate injection for gastric varices: case ...
  • Splenic infarction is a condition in which blood flow supply to the spleen is compromised, leading to partial or complete infarction (tissue death due to oxygen shortage) in the organ. (wikipedia.org)
  • In sickle cell disease, repeated splenic infarctions lead to a non-functional spleen (autosplenectomy). (wikipedia.org)
  • Examples include abdominal traumas, aortic dissection, torsion of the splenic artery (for example, in wandering spleen) or external compression on the artery by a tumor. (wikipedia.org)
  • Splenic infarction is the death of tissue (necrosis) in the spleen due to a blockage in blood flow. (medlineplus.gov)
  • Splenic infarction is a result of ischemia to the spleen , and in many cases requires no treatment. (radiopaedia.org)
  • Splenic infarcts can occur due to a number of processes, involving either arterial supply, the spleen itself or the venous drainage. (radiopaedia.org)
  • In cases of torsion of a wandering spleen, splenopexy with splenic salvage is the procedure of choice in the well-perfused, noninfarcted spleen. (medscape.com)
  • Whereas a unilocular abscess can be managed successfully in select cases with percutaneous catheter drainage, some authors advocate splenectomy in all cases of splenic infarct and abscess, questioning the utility of preserving the residual, partially functioning spleen. (medscape.com)
  • Intraoperative ligation of the splenic artery at the superior margin of the pancreas in the lesser sac is another alternative to minimize blood loss if the spleen is enlarged. (medscape.com)
  • Changes in spleen structure, frequently encountered during malaria, may result either in a simple asymptomatic enlargement or in serious complications such as hematoma, rupture, or infarction ( 1 - 3 ). (cdc.gov)
  • Hematoma or infarction of the spleen might be followed by the development of a splenic abscess, a clinical condition that has been reported in only 1 patient, to our knowledge ( 4 ). (cdc.gov)
  • An enlarged spleen is found in 50% to 80% of malaria patients ( 1 ), while only 25 cases of splenic rupture have been reported since 1960 (0%-2% in natural occurring infection) ( 5 ). (cdc.gov)
  • Spleen infarction is rarer than rupture and may go unnoticed. (cdc.gov)
  • Indeed, splenic hematoma or infarction, together with the humoral and cellular immunodepression due to malaria, might well be predisposing factors for bacterial (e.g., salmonellae) colonization of the spleen from the gut, as likely happened in this patient, although cultures of the pus, blood, or intraabdominal fluid were not performed. (cdc.gov)
  • The arterial supply to the spleen consists of the splenic artery (a branch of the celiac axis) and the short gastric arteries (branches of the left gastroepiploic artery), which supply the upper pole of the spleen. (medscape.com)
  • Most commonly, these infarcts contract and fibrose over time, as demonstrated by the sickle hemoglobinopathies (in which repeated episodes of infarction ultimately result in autoinfarction of the spleen). (medscape.com)
  • The spleen, sometimes called "the forgotten organ" of the abdomen, has received less attention than other abdominal solid organs, as splenic diseases are less common and frequently clinically asymptomatic [ 1 ]. (e-ultrasonography.org)
  • Accessory spleen, which results from a failure of the embryonic splenic anlage to fuse and extreme lobulation that separates splenic tissue, is a normal variant observed in 10%-30% of individuals [ 7 ]. (e-ultrasonography.org)
  • Computed tomography scan displayed a hypodense spleen lesion suggestive of splenic infarction. (farabiretina.com)
  • The splenic artery supplies blood to the spleen. (medscape.com)
  • Splenic infarction occurs when the splenic artery or one of its branches are occluded, for example by a blood clot. (wikipedia.org)
  • Any factor that directly compromises the splenic artery can cause infarction. (wikipedia.org)
  • Patients underwent baseline angiography of the celiac trunk, superior mesenteric artery, hepatic artery, and splenic artery using a peripheral arterial approach. (hindawi.com)
  • Even with occlusion of the main splenic artery, collateral flow from the short gastric arteries often may preserve some or all of the splenic parenchyma. (medscape.com)
  • These include coronary artery vasospasm, transient myocardial ischemia, myocardial infarction, ventricular tachycardia and ventricular fibrillation. (ncats.io)
  • Its terminal branches aside, the splenic artery also gives off branches to the pancreas, 5-7 short gastric branches, and the left gastro-omental (gastroepiploic) artery (see the image below). (medscape.com)
  • Agbeille Mohamed F, Hadonou AA, Noudamadjo A, Kpanidja MG, Doha F, Adédémy JD, Agossou J. Massive Splenic Infarction Abscess in A Teenager with Sickle Cell Disease: A Case Report in Northern Benin. (asploro.com)
  • Splenic abscess is rare in children. (asploro.com)
  • This report discusses a case of splenic abscess complicating an infarction in a teenager at the Teaching Hospital of Borgou/Alibori in Benin Republic. (asploro.com)
  • Abdominal ultrasound and thoraco-abdominal CT-scan revealed a splenic infarction abscess. (asploro.com)
  • Splenic abscess should be suspected in any subject with sickle cell disease presenting with painful and febrile splenomegaly. (asploro.com)
  • Splenic abscess can result from septic emboli or superinfection of a prior infarct. (medscape.com)
  • [ 4 ] In certain circumstances, isolated splenic abscess can be treated with percutaneous drainage alone, and splenectomy can be avoided. (medscape.com)
  • two of the cases were associated with a mycotic aneurysm, and one case was associated with a splenic abscess. (biomedcentral.com)
  • The third patient had a splenic infarction and abscess associated with infected cardiac thrombi. (biomedcentral.com)
  • two were associated with MA, and one was associated with splenic abscess. (biomedcentral.com)
  • Acute splenic tenderness indicates splenic infarction or abscess formation. (medicosnotes.com)
  • [ 4 ] Splenic embolization may result from various cardiovascular conditions, including a left atrial or ventricular mural thrombus that formed as a result of acute myocardial infarction or atrial fibrillation or developed from complications of cardiac catheterization or bacterial endocarditis. (medscape.com)
  • The appearance of splenic infarction depends on the timing of imaging and the size of the infarct. (radiopaedia.org)
  • Morphologically the typical infarct is of a pyramidal wedge of affected splenic tissue with the apex pointing towards the hilum, and the base on the splenic capsule. (radiopaedia.org)
  • We report the case of splenic infarct secondary to embolisation from a polypoid 17 mm x 10 mm thoracic aorta thrombi in a 60 year-old female. (edu.au)
  • Another mechanical cause of splenic infarct can be the injection of gastric varices in the setting of portal hypertension and gastric variceal bleeding. (medscape.com)
  • Splenic infarct has also been reported in association with postpartum toxic shock syndrome. (medscape.com)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. (rxlist.com)
  • Myocardial ischemia/infarction and Prinzmetal's angina: Perform cardiac evaluation in patients with multiple cardiovascular risk factors. (nih.gov)
  • Impact of Beta Blockers on Left Ventricular Reverse Remodeling Following Primary Coronary Intervention for ST-elevation Myocardial Infarction. (imed.pub)
  • We retrospectively evaluated the long-term effects of partial splenic embolization (PSE) with transarterial chemoembolization (TACE) in patients with HCC patients accompanied by thrombocytopenia. (hindawi.com)
  • Over the past 20 years, partial splenic embolization (PSE) has been an interventional radiological treatment for thrombocytopenia due to hypersplenism [ 3 , 4 ]. (hindawi.com)
  • Splenic infarction refers to occlusion of the splenic vascular supply, leading to parenchymal ischemia and subsequent tissue necrosis. (medscape.com)
  • Splenic infarction can also result from a sickle cell crisis in patients with sickle cell anemia. (wikipedia.org)
  • Splenic infarctions are common in sickle cell anemia patients (SCA). (biogossip.com)
  • Splenic vein thrombosis, most commonly the result of pancreatitis or surgery, can result in venous infarction. (medscape.com)
  • A CT revealed a splenic infarction with splenic vein thrombosis and a 2 cm mass of the pancreatic tail. (egeus.org)
  • C-4: Splenic vein thrombosis of the same patient is marked by arrows. (medscape.com)
  • Only 9 documented cases of splenic infarction associated with malaria have been reported ( 3 ), all consequent to P . falciparum infection (except in 1 patient who was coinfected with P . vivax and 2 cases in which the etiologic agent was unknown). (cdc.gov)
  • The incidence of splenic hematoma without rupture is unknown ( 2 ). (cdc.gov)
  • As technologies evolve, laparoscopic splenic preservation may become the future standard of care for segmental infarcts. (medscape.com)
  • In a single-center retrospective cases review, people who were admitted to the hospital with a confirmed diagnosis of acute splenic infarction, cardiogenic emboli was the dominant etiology followed by atrial fibrillation, autoimmune disease, associated infection, and hematological malignancy. (wikipedia.org)
  • Splenic infarction and malaria. (nih.gov)
  • Missed splenic rupture or delayed diagnosis is associated with a 10-fold increase in mortality over the rate associated with prompt recognition of injury. (medscape.com)
  • A break of a contained hematoma is usually involved in splenic rupture, which occurs almost exclusively during acute infection and the primary attack ( 6 ). (cdc.gov)
  • Splenic rupture following infarction has not yet been described. (cdc.gov)
  • multiple infarcts appear as hypodense non-enhancing lesions, with normal intervening enhancing splenic tissue. (radiopaedia.org)
  • On histologic examination, splenic tissue was found to have been replaced by congested inflammatory infiltrates and fibrotic tissue. (cdc.gov)
  • The classic presentation of splenic injury includes hemodynamic instability, severe abdominal pain, and symptoms of peritonitis. (medscape.com)
  • Therefore, US is widely used and frequently chosen as the first imaging modality for most abdominal imaging, both for general abdominal examinations and for patients suspected of having splenic diseases. (e-ultrasonography.org)
  • The American Association for the Surgery of Trauma (AAST) splenic injury scale is based on computed tomography (CT) findings, as follows. (medscape.com)
  • in almost half of the patients with infarction, the diagnosis was made incidentally on computed tomography (CT). (medscape.com)
  • Therefore, this pictorial essay elucidates the US findings of various splenic lesions, in correlation with computed tomography (CT) or magnetic resonance (MR) imaging and pathology. (e-ultrasonography.org)
  • Various other conditions have been associated with splenic infarction in case reports, for example granulomatosis with polyangiitis or treatment with medications that predispose to vasospasm or blood clot formation, such as vasoconstrictors used to treat esophageal varices, sumatriptan or bevacizumab. (wikipedia.org)
  • However, a patient with multiple splenic abscesses usually will require splenectomy. (medscape.com)
  • Complications, such as bleeding or pseudocyst formation, also may be amenable to splenic salvage using techniques of partial splenectomy. (medscape.com)
  • As laparoscopic techniques become more advanced, many of the surgical problems associated with splenic infarction certainly will prove amenable to laparoscopic splenectomy or partial splenectomy. (medscape.com)
  • Eight (3%) of the 271 children required splenectomy (1 after the initial episode of ASSC, 3 after a second episode of ASSC, 2 as a result of pain accompanying chronic infarction and ASSC, and 2 because of splenic hemorrhage). (elsevierpure.com)
  • Repeated splenic infarction may be an indication for splenectomy. (medicosnotes.com)
  • [ 12 ] Complications of splenic infarction were a frequent indication (60%) for operation in patients with septic emboli. (medscape.com)
  • Objective: To determine the frequency and severity of acute splenic complications in children and adolescents with sickle cell (SC) hemoglobin C disease. (elsevierpure.com)
  • Results: Sixteen (6%) children had acute splenic complications. (elsevierpure.com)
  • Conclusions: We conclude that (1) acute splenic complications in children and adolescents with SC disease are relatively uncommon, (2) most episodes of ASSC occur in preadolescents, (3) ASSC can be life threatening, even in younger children, and (4) prior splenomegaly is not a good predictor of ASSC. (elsevierpure.com)
  • If liquefaction occurs, the area may be rounded and anechoic ( splenic pseudocyst ). (radiopaedia.org)
  • A third mechanism for splenic trauma is explosive-type injuries, such as occurs in warfare and civilian bombing. (medscape.com)
  • Hypotension in a patient with a suspected splenic injury can be a grave sign and a surgical emergency. (medscape.com)
  • C-6: Ultrasound image of the same patient showing a larger infarction/collection? (medscape.com)
  • It is usually found around the splenic hilum or ligaments, pancreatic tail, or sometimes in the pancreatic parenchyma [ 7 ]. (e-ultrasonography.org)
  • The hilum transmits the splenic vessels and nerves and provides attachment to the gastrosplenic and splenorenal (lienorenal) ligaments. (medscape.com)
  • It should be noted that ~40% (range 30-50%) of patients with splenic infarction are asymptomatic 9 . (radiopaedia.org)
  • Knowledge of the US features of various splenic lesions will help narrow the differential diagnosis and guide clinical decision-making. (e-ultrasonography.org)
  • Concomitantly with the increasing frequency of imaging, more splenic lesions are being discovered and the requirements for the differential diagnosis are rising. (e-ultrasonography.org)
  • In this pictorial essay, we introduce the representative US findings of many different splenic lesions, including normal sonographic findings, normal variants and congenital anomalies, infectious conditions, benign and malignant neoplasms, and non-neoplastic lesions. (e-ultrasonography.org)
  • However, with the increasing frequency of imaging and advances in imaging technology, more incidental splenic lesions are being discovered and the subsequent requirements for the differential diagnosis are growing. (e-ultrasonography.org)
  • Splenic infarction alone is not an indication for surgery. (medscape.com)
  • In the hyperacute phase, CT may show areas of mottled increased attenuation, representing areas of a hemorrhagic infarction. (radiopaedia.org)
  • Infiltrative hematologic diseases cause congestion of the splenic circulation by abnormal cells. (medscape.com)
  • In malignant hematologic diseases (eg, chronic myeloid leukemia), increased splenic oxygen requirements secondary to an increased splenic mass, coupled with a decreased oxygen-carrying capacity secondary to the anemia of hypersplenism, lead to infarction. (medscape.com)
  • However, to the authors' knowledge, there are not enough up-to-date ultrasonographic imaging reviews of splenic diseases [ 2 - 5 ]. (e-ultrasonography.org)
  • Because of the (admittedly small) risk of fatal OPSS, splenic preservation is preferable whenever possible. (medscape.com)
  • There is great interest regarding the extension of the safe indications for splenic preservation. (medscape.com)
  • In fact, overall, most splenic infarcts do not require surgical intervention. (medscape.com)
  • Other causes of splenomegaly (for example, Gaucher disease or hemoglobinopathies) can also predispose to infarction. (wikipedia.org)
  • Patients with a splenic infarction may present with left upper quadrant pain. (radiopaedia.org)
  • A FAST exam should be instituted in hemodynamically unstable patients with splenic trauma to assess the degree of both trauma and bleeding. (medscape.com)
  • Three additional patients had a history of acute painful splenic infarction, two of whom also had splenic hemorrhage. (elsevierpure.com)
  • Splenic infarction can be due to vasculitis or disseminated intravascular coagulation. (wikipedia.org)
  • it contains the tail of the pancreas and splenic vessels. (medscape.com)
  • In individuals who are heterozygous for sickle trait, exposure to low-oxygen tension (eg, during unpressurized airplane travel) or vigorous activity (eg, skiing in high-altitude locations) can precipitate sickling and splenic infarction by the above-described mechanism. (medscape.com)
  • [ 3 ] In myelofibrosis, the splenic parenchyma is infiltrated by extramedullary hematopoiesis, causing congestion of the splenic circulation. (medscape.com)
  • The splenic circulation is adapted for the separation and storage of the red blood cells. (medscape.com)
  • Splenic infarction is also more common in hematological disorders with associated splenomegaly, such as the myeloproliferative disorders. (wikipedia.org)
  • Infectious Mononucleosis-Induced Splenic Infarction: Perhaps More Common in Healthy Individuals Than Previously Thought. (hcahealthcare.com)
  • Mamo G, Erickson S, Komanduri K, Zayas D, Aggarwal N. Infectious Mononucleosis-Induced Splenic Infarction: Perhaps More Common in Healthy Individuals Than Previously Thought. (hcahealthcare.com)
  • Thromboembolism is another common cause of splenic infarcts. (medscape.com)