A disease of cats and mink characterized by a marked inflammation of adipose tissue and the deposition of "ceroid" pigment in the interstices of the adipose cells. It is believed to be caused by feeding diets containing too much unsaturated fatty acid and too little vitamin E. (Merck Veterinary Manual, 5th ed; Stedman, 25th ed)

The histopathology and ultrastructure of steatitis affecting common dab Limanda limanda. (1/12)

This study presents a new description, based on histopathological and ultrastructural studies, of a disease affecting the common dab Limanda limanda (L.). The condition can be recognised by the presence of multiple orange or yellow lesions in the pterygophorial region of the fish. The principal histopathological features are necrosis of fat cells, extensive macrophage infiltration leading to the formation of granulomatous structures, and the accumulation of lipopigment by lipid peroxidation. Based on this description, the condition has been diagnosed as steatitis. Although pathology associated with lipid peroxidation is the dominant characteristic of the lesions examined, it is proposed that this process is secondary to necrosis of the adipose tissue. The aetiology is discussed in the light of these observations. In addition, the first record of this condition affecting long rough dab Hippoglossoides platessoides (Fabricius) is made.  (+info)

P-selectin glycoprotein ligand-1 (rPSGL-Ig)-mediated blockade of CD62 selectin molecules protects rat steatotic liver grafts from ischemia/reperfusion injury. (2/12)

We examined the effects of early blockade of CD62 selectin-mediated adhesive interactions in steatotic rat liver models of ex vivo cold ischemia followed by reperfusion or transplantation by administration of P-selectin glycoprotein ligand-1 (rPSGL-Ig). In the model of cold ischemia/reperfusion, livers pretreated ex vivo with rPSGL-Ig at harvesting from obese Zucker rats showed significantly decreased portal resistance, increased bile production, and diminished hepatic endothelial neutrophil infiltration, as compared with untreated controls. Pretreatment of fatty livers with rPSGL-Ig prior to transplantation extended the survival of lean Zucker rat recipients from 40% to 90%. This effect correlated with significantly improved liver function, depressed neutrophil activity, and decreased histologic features of hepatocyte injury. Intragraft expression of CD62 P-selectin was similar in both recipient groups. rPSGL-Ig treatment decreased intragraft infiltration by CD3/CD25 cells, diminished expression of pro-inflammatory TNFalpha, IL-6, iNOS, IL-2 and IFN-gamma, without significantly affecting mRNA levels coding for anti-inflammatory IL-4. Thus, rPSGL-Ig blockade of CD62-mediated adhesive interactions protects against severe ischemia/reperfusion injury suffered otherwise by steatotic rat livers. These findings document the potential utility of rPSGL-Ig in increasing the transplant donor pool through modulation of marginal steatotic livers.  (+info)

Evaluation of abnormal liver function tests. (3/12)

Interpretation of abnormalities in liver function tests is a common problem faced by clinicians. This has become more common with the introduction of automated routine laboratory testing. Not all persons with one or more abnormalities in these tests actually have liver disease. The various biochemical tests, their pathophysiology, and an approach to the interpretation of abnormal liver function tests are discussed in this review.  (+info)

Anemia, myopathy, and pansteatitis in vitamin E-deficient captive marmosets (Callithrix spp.). (4/12)

Five young adult pet marmosets (Callithrix spp.) were presented with weight loss (5/5); fecal retention (3/5); diarrhea (2/5); impaired locomotion (3/5); anemia (4/4); hypoproteinemia or hypoalbuminemia (3/4); elevations of creatine phosphokinase, lactic dehydrogenase, and alanine aminotransferase (3/4); and renal failure with hypercholesterolemia (2/4). All anemic marmosets had low serum vitamin E levels. The anemia responded to vitamin E and selenium therapy in two marmosets. One of the five marmosets died before presentation, and two others died despite therapy. The two marmosets necropsied had degenerative myopathy, pyogranulomatous pansteatitis, and increased erythrophagocytosis and hemosiderosis. The striated muscle and adipose tissue of both marmosets were negative for coxsackievirus ribonucleic acid by in situ hybridization. These findings suggest that vitamin E deficiency may be involved in the development of anemia, myopathy, and steatitis in callitrichids; however, in some marmosets, underlying diseases such as chronic colitis may have influenced the development of anemia and impaired vitamin E status.  (+info)

The ins and outs of mitochondrial dysfunction in NASH. (5/12)

Rich diet and lack of exercise are causing a surge in obesity, insulin resistance and steatosis, which can evolve into steatohepatitis. Steatosis and nonalcoholic steatohepatitis (NASH) can also be induced by drugs such as amiodarone, tamoxifen and some antiretroviral drugs. There is growing evidence that mitochondrial dysfunction, and more specifically respiratory chain deficiency, plays a role in the pathophysiology of NASH whatever its initial cause. In contrast, the B-oxidation of fatty acids can be either increased (as in insulin resistance-associated NASH) or decreased (as in drug-induced NASH). However, in both circumstances, the generation of reactive oxygen species (ROS) by the damaged respiratory chain is augmented, as components of this chain are over-reduced by electrons, which then abnormally react with oxygen to form increased amounts of ROS. Concomitantly, ROS oxidize fat deposits to release lipid peroxidation products that have detrimental effects on hepatocytes and other hepatic cells. In hepatocytes, ROS and lipid peroxidation products further impair the respiratory chain, either directly or indirectly through oxidative damage to the mitochondrial genome. This, in turn, leads to the generation of more ROS and a vicious cycle ensues. Mitochondrial dysfunction can also lead to apoptosis or necrosis depending on the energy status of the cell. ROS and lipid peroxidation products also activate stellate cells, thus resulting in fibrosis. Finally, ROS and lipid peroxidation increase the generation of several cytokines (TNF-alpha, TGF-B, Fas ligand) that play sundry roles in the pathogenesis of NASH. Recent investigations have shown that some genetic polymorphisms can significantly increase the risk of steatohepatitis and that several drugs can prevent or even reverse NASH. For the next decade, reducing the incidence of NASH will be a major challenge for hepatologists.  (+info)

Hepatocellular toxicosis associated with the alternate administration of carprofen and meloxicam in a siberian husky. (6/12)

A 4-year-old female Siberian Husky was diagnosed with pyogranulomatous steatitis at the site of a recurrence of left anal sac rupture (day 1). Carprofen and orbifloxacin were given for 13 days without improvement. A single dose of meloxicam was administered prior to surgical resection of the anal sac, and based on elevated liver enzyme activity, liver supportive therapy was initiated. The dog received carprofen and orbifloxacin orally on the evening of day 14. The dog became anorectic the following morning, and began vomiting. Despite supportive therapy, the dog was unresponsive to treatment and died on day 16. Postmortem examination revealed severe vacuolar change and acute necrosis of hepatocytes consistent with carprofen and meloxicam induced-toxicosis.  (+info)

The proinflammatory phenotype of PECAM-1-deficient mice results in atherogenic diet-induced steatohepatitis. (7/12)

The severity of nonalcoholic steatohepatitis (NASH) is determined by environmental and genetic factors, the latter of which are incompletely characterized. Platelet endothelial cell adhesion molecule-1 (PECAM-1) is a 130-kDa transmembrane glycoprotein expressed on blood and vascular cells. In the present study, we provide data for the novel finding that genetic deficiency of PECAM-1 potentiates the development and progression of NASH. We found that the rate of development and severity of diet-induced NASH are markedly enhanced in PECAM-1-deficient [knockout (KO)] mice relative to wild-type (WT) mice, as measured by histological and biochemical evaluation. Livers from KO mice exhibited typical histological features of NASH, including macrovesicular fat accumulation, hepatocyte injury with infiltration of inflammatory cells, fibrosis, and heightened oxidative stress. Alanine aminotransferase, a marker for liver injury, was also significantly higher in KO compared with WT mice. Consistent with a role for PECAM-1 as a suppressor of proinflammatory cytokines, plasma levels of inflammatory cytokines, including TNF-alpha and monocyte chemoattractant protein-1 (MCP-1), were also significantly higher in KO compared with WT mice. These findings are the first to show that the PECAM-1-deficient mouse develops progressive nonalcoholic fatty liver disease (NAFLD), supporting a role for PECAM-1 as a negative regulator of NAFLD progression. Future examination of recently identified PECAM-1 allelic isoforms in humans as potential risk factors for developing NASH may be warranted.  (+info)

Cytomegalovirus infection of adipose tissues induces steatitis in adult mice. (8/12)

Young adult mice infected with MCMV were shown to develop inflammatory lesions in the peripancreatic and salivary gland adipose tissues. MCMV replication was detected by immunoperoxidase staining and electron microscopy in adipocytes, fibroblasts, endothelial cells and pericytes in brown and white adipose tissues. More infected cells were detected in C3H mice than in BALB/c, BALB.B, BALB.K or C57BL/6 mice. Peripancreatic steatitis consisted of a monocytic infiltrate surrounding focal necrosis of adipocytes, the severity of which was influenced by the route of inoculation, virus dose, and genetic susceptibility to disseminated MCMV-disease. C57BL/6 mice showed the greatest susceptibility with severe coalescing focal inflammation around areas of coagulative necrosis. Salivary gland adipose tissues exhibited lymphocytic steatitis, which was reduced in Nu/Nu mice.  (+info)

Steatitis is a medical term that refers to the inflammation of fatty tissue, also known as nonalcoholic fatty liver disease (NAFLD) when it occurs in the liver. It is often caused by the accumulation of large amounts of fat within cells, leading to oxidative stress and an immune response.

Steatitis can occur in various parts of the body, including the abdominal cavity, bone marrow, and other organs. However, when it occurs in the liver, it is often associated with obesity, metabolic syndrome, and diabetes. In severe cases, steatitis in the liver can lead to scarring, cirrhosis, and even liver failure.

Symptoms of steatitis may include fatigue, abdominal pain or discomfort, loss of appetite, weight loss, and nausea. Diagnosis typically involves a combination of physical exam, medical history, imaging studies, and laboratory tests. Treatment options may include lifestyle changes such as diet and exercise, medications to manage underlying conditions, and in some cases, surgery.

487 The general term for inflammation of any adipose tissue is steatitis. Panniculitis can also be classified based on the ...
Vitamin E is another required vitamin in kitten diets; deficiency leads to steatitis, causing the depot fat to become firm and ...
Prostatitis Vesiculitis Cowperitis Balanitis Posthitis Insulitis Hypophysitis Thyroiditis Parathyroiditis Adrenalitis Steatitis ...
... steatitis MeSH C18.654.521.500.133.912 - vitamin K deficiency MeSH C18.654.521.500.133.912.360 - hemorrhagic disease of newborn ...
Steatitis or "yellow fat disease" has been noted when sources of highly unsaturated fatty acids (e.g., tuna fish oil, cod liver ...
Archival necropsy data (,1,000 animals over 24 years) were negative for prior cases of severe T. gondii-associated steatitis ... Archival necropsy data (,1,000 animals over 24 years) were negative for prior cases of severe T. gondii-associated steatitis ... and toxoplasmosis with severe protozoal steatitis was the primary cause of death for all cases. This lesion pattern differs ... and toxoplasmosis with severe protozoal steatitis was the primary cause of death for all cases. This lesion pattern differs ...
Steatitis was diagnosed in all GBH. Steatitis is defined as an inflammation of adipose tissue. In mammals, it is associated ... Steatitis has been reported in several other bird species (black crowned night heron Nycticorax nycticorax, osprey Pandion ... Microcystin Toxicity Concurrent with Steatitis in Great Blue Herons (Ardea herodias) in Maryland in 2001 ...
The histopathology and ultrastructure of steatitis affecting common dab Limanda limanda G. S. Begg1,2,*, D. W. Bruno1, A. H. ... Cite this article as: Begg GS, Bruno DW, McVicar AH1 (2000) The histopathology and ultrastructure of steatitis affecting common ... KEY WORDS: Steatitis · Fat cell necrosis · Macrophage infiltration · Lipid peroxidation · Common dab Limanda limanda ... Based on this description, the condition has been diagnosed as steatitis. Although pathology associated with lipid peroxidation ...
487 The general term for inflammation of any adipose tissue is steatitis. Panniculitis can also be classified based on the ...
Histologic examination results for samples obtained during surgery demonstrated suppurative myositis and steatitis. These ... We can conclude that idiopathic sterile epidural steatitis can be a cause of thoracolumbar myelopathy and severe spinal pain, ... Histologic examination revealed a suppurative myositis and suppurative steatitis of the epidural fat. Samples of the skin and ... These findings confirmed a diagnosis of suppurative myositis and suppurative epidural steatitis. In light of the negative ...
Histologic examination results for samples obtained during surgery demonstrated suppurative myositis and steatitis. These ...
01.09.2017 Steatitis in equids - clinical and ultrasonographical findings. *30.08.2017 Correlation of overground endoscopy to ...
Cats fed only fish developed thiamin deficiency and steatitis. By learning about the nutritional needs of pets and formulating ...
Yellow Fat Disease (Steatitis) Yellow fat disease is a condition in which inflammation of the fatty tissue (which develops a ...
Tuna Leads Cat to Develop Steatitis:. Image Source unsplash.com. Steatitis is a rare disease related to the physical health of ...
Inflammation: vasculitis, peritonitis, steatitis, etc. *. Idiopathic: congestive heart failure, egg retention, dystocia, ...
04.25.21Omega 3 Senility & Steatitis. * 04.23.21Supplementing With Smog. * 04.22.21Myocardial Lipofuscinosis ...
COELOMIC STEATITIS IN TENTACLED SNAKES (ERPETON TENTACULATUM) Imogen L. Payne, Andrew F. Rich, Javier Lopez, Gerardo García, ... A retrospective study revealed seven cases of coelomic steatitis in adult tentacled snakes (Erpeton tentaculatum), including ... This case study represents the first report of coelomic steatitis in tentacled snakes of unconfirmed etiology but with a ... Three females exhibited intralesional yolk fluid associated with periovarian steatitis. Hepatic lipidosis was the second most ...
Deficiency: Sterility (males) steatitis, dermatosis, immunodeficiency, anorexia, myopathy. Excess: Minimally toxic. Fat-soluble ...
Wallach JD, Hoessle C. Steatitis in captive crocodilians. J Am Vet Med Assoc. 1968 Oct 1;153(7). ...
Steatitis is a dangerous condition that requires veterinary attention.. *‌Too much phosphorous and magnesium.‌ If your cat is ... This can result in a condition called steatitis, which is inflammation of the fat. This is more likely to occur in overweight ...
An unusual main finding was steatitis (20.9%) of unknown origin. Animals were mainly emaciated and showed high infection rates ...
Cytomegalovirus infection of adipose tissues induces steatitis in adult mice. abstract::Young adult mice infected with MCMV ...
All had severe inflammation of their body fat - a condition called steatitis. Severe steatitis is a very unusual finding in sea ... Reference: "Newly detected, virulent Toxoplasma gondii COUG strain causing fatal steatitis and toxoplasmosis in southern sea ...
Amygdaliform phoronida wrung that of order flexeril cost of tablet everybody poetlike steatitis. get cyclobenzaprine australia ... Amygdaliform phoronida get flexeril using mastercard wrung that of everybody poetlike steatitis. Enneadic owing to canada ...
Steatitis, the inflammation in dogs, are harder to find than in human beings. You will know that your dog has inflammation when ...
Abstract The Atlantic bottlenose dolphin (BND) has attracted the interest of marine bioscientists as a potential sentinel for human health, due to the remarkable sensitivity of the dolphins own health to environmental changes in its aquatic habitat and due to this marine mammals relative likeness to humans. Consequently, a greater knowledge of how BND responds to environmental stress is needed, but such studies are limited by its status as a protected species. We have established cell cultures and cell lines from the epidermis of BND as an in vitro tool for evaluating the impacts of environmental stressors and biotoxins on this marine mammal. Such cell models provide a novel experimental methodology to studying dolphin skin as well as a system for comparing the responses of marine mammals and humans to various insults. We have begun evaluation of BND skin cell cultures exposed to varying concentrations of salinity using two-dimensional differential in-gel electrophoresis (DIGE) and cDNA ...
... tuna can cause a severe vitamin E deficiency resulting in a very painful inflammatory condition called steatitis. Albacore tuna ...
Tuna doesnt have adequate amounts of vitamin E and this may lead to a condition called steatitis (also known as yellow fat ...
However, too much tuna puts the kitten at risk of contracting Steatitis, mercury poisoning, poor cognitive bloodhunt free cheat ...
... thus cats can develop a deficiency of Vitamin E and a condition called Steatitis a.k.a. Yellow Fat. ...
... steatitis, and other damages ...
... steatitis * prostatitis * pyelonephritis * pyometra (infection of the uterus) * urinary obstruction * diaphragmatic hernia * ...
... including pancreatomegaly with presumptive pancreatitis and steatitis, cholecystic debris and common bile duct thickening ( ...
Steatitis, USGS Science Data Catalog (SDC), Vitamin E, Wildlife Biology, Wildlife Biology, biota, Fewer tags ... steatitis confirmed at necropsy) were observed at Poplar Island and nearby Coaches Island (Rattner et al. 2006). Birds were ...
  • Steatitis is defined as an inflammation of adipose tissue. (vin.com)
  • 487 The general term for inflammation of any adipose tissue is steatitis. (wikipedia.org)
  • This can result in a condition called steatitis, which is inflammation of the fat. (cuteness.com)
  • All had severe inflammation of their body fat - a condition called steatitis. (focustechnica.com)
  • The first thought is that of inflammation with edema or free fluid between the lobes of fat ( steatitis) but once again we can get the same appearance in a normal dog.So it could be either here. (sonopath.com)
  • Tuna doesn't have adequate amounts of vitamin E and this may lead to a condition called steatitis (also known as yellow fat disease). (quadronmusic.com)
  • In the fall of 2005, dead and dying great blue herons (Ardea herodias) exhibiting emaciation, lethargy, inability to fly and a hard abdomen (steatitis confirmed at necropsy) were observed at Poplar Island and nearby Coaches Island (Rattner et al. (usgs.gov)
  • When packed in oil, tuna can cause a severe vitamin E deficiency resulting in a very painful inflammatory condition called steatitis. (metropetmarket.ca)
  • Apart from that, tuna has high amount of unsaturated fat content, thus cats can develop a deficiency of Vitamin E and a condition called Steatitis a.k.a. (dearpet.in)
  • From February 2020 to March 2022, four southern sea otters ( Enhydra lutris nereis ) stranded in California with severe protozoal steatitis and systemic toxoplasmosis. (frontiersin.org)
  • 1,000 animals over 24 years) were negative for prior cases of severe T. gondii -associated steatitis prior to the cases described herein, and no sublethal COUG T. gondii infections have been previously indentified in sea otters. (frontiersin.org)
  • Severe steatitis is a very unusual finding in sea otters with toxoplasmosis. (focustechnica.com)
  • Based on this description, the condition has been diagnosed as steatitis. (int-res.com)
  • Steatitis is a dangerous condition that requires veterinary attention. (cuteness.com)
  • High parasite burdens were observed in all tissues except the central nervous system, and toxoplasmosis with severe protozoal steatitis was the primary cause of death for all cases. (frontiersin.org)
  • Begg GS, Bruno DW, McVicar AH 1 (2000) The histopathology and ultrastructure of steatitis affecting common dab Limanda limanda . (int-res.com)
  • Cats that eat too much tuna can have health problems like feline steatitis, which affects the quality of the lipids found in their bodies, loss of balance, neurological failures, calcium, iron or sodium deficiency and even mercury poisoning. (sepicat.com)
  • 487 The general term for inflammation of any adipose tissue is steatitis. (wikipedia.org)
  • While only onefat depot is affected in the localized form, the disease involves several fat depots in the generalized form.Localized steatitis at the level of the perivaginal adipose tissue has not yet been described in the horse. (ugent.be)
  • Waxy Yellow Fat Disease / White Fat Disease / Steatitis / Pansteatitis / Nonsuppurative Pansteatitis / Weber-Christian Disease / Fatty Necrosis / White Muscle Disease / Stiff Lamb Disease / Stiff Calf Disease / Watery Hide Disease / Nutritional Fat Necrosis / Nutritional Myodegeneration (NMD) / Nutritional Myopathy / Nutritional Muscular Dystrophy / Brown Heart Disease / Cardiac Necrosis / Hepatic Steatosis / Hepatic Dietetica / Granulomatous Steatitis / Necrotizing Granulomatous Steatitis / Nonalcoholic Fatty Liver Disease / Embryonic Death Syndrome / Ceroid Disease / Lipofuscinosis / Cumulative Lipofuscinosis / Progressive Lipofuscinosis / Etc. (oneradionetwork.com)
  • Pansteatitis-affected catfish, kept in an experimental pond for 11 months after the inciting nutritional cause had been removed, retained steatitis lesions almost unaltered. (up.ac.za)