Cytotoxic cardenolide glycosides of Roupellina (Strophanthus) boivinii from the Madagascar rainforest. (1/2)
Bioassay-guided fractionation of an ethanol extract of Roupellina (Strophanthus) boivinii from the rainforest of Madagascar afforded the six new cardenolide glycosides boivinides 1-6, as well as the four known cardenolide glycosides digitoxigenin 3-O-[beta-D-glucopyrananosyl-(1-->4)-alpha-L-acofriopyranoside], corotoxigenin 3-O-beta-D-boivinoside, 17alpha-corotoxigenin 3-O-beta-D-sarmentoside, and uzarigenin 3-O-alpha-L-rhamnoside. The structures of these compounds were elucidated by various 1D and 2D NMR techniques. All new compounds showed significant antiproliferative activity against the A2780 human ovarian cancer cell line, with boivinide A being the most active at IC50 = 0.17 microM. (+info)Glycosylation of trans-resveratrol by plant-cultured cells. (2/2)
Plant-cultured cells of Catharanthus roseus converted trans-resveratrol into its 3-O-beta-D-glucopyranoside, 4'-O-beta-D-glucopyranoside, 3-O-(6-O-beta-D-xylopyranosyl)-beta-D-glucopyranoside, and 3-O-(6-O-alpha-L-arabinopyranosyl)-beta-D-glucopyranoside. The 3-O-(6-O-beta-D-xylopyranosyl)-beta-D-glucopyranoside and 3-O-(6-O-alpha-L-arabinopyranosyl)-beta-D-glucopyranoside compounds of trans-resveratrol are both new. Incubation of plant-cultured cells of Ipomoea batatas and Strophanthus gratus with trans-resveratrol gave trans-resveratrol 3-O-beta-D-glucopyranoside and trans-resveratrol 4'-O-beta-D-glucopyranoside. (+info)Strophanthus is a genus of plants, native to tropical Africa and Asia, containing cardiac glycosides such as strophanthin, used medically as a rapid-acting cardiotonic and in the treatment of certain heart conditions.
Strophanthus is not a medical term itself, but it refers to a genus of plants that contain cardiac glycosides, which have been used in traditional medicine and pharmacology. The most notable cardiac glycoside found in Strophanthus species is strophanthin (ouabain).
Strophanthin has positive inotropic (contractility-enhancing) and negative chronotropic (rate-slowing) effects on the heart, making it useful in treating various cardiac conditions. However, due to its narrow therapeutic index and potential toxicity, strophanthin is not commonly used in modern medicine.
In a medical context, when referring to 'Strophanthus,' it would typically be in relation to these pharmacological properties or historical/traditional uses of the plant's extracts.
Gratus2
- The researchers speculate that the giant butterfly most likely gets its venom when its caterpillar ingests the leaves of Strophanthus gratus - a thick, woody liana that winds among the treetops and bears flagrant flowers. (courthousenews.com)
- Cardiac glycosides are found in a diverse group of plants including Digitalis purpurea and Digitalis lanata (foxgloves), Nerium oleander (common oleander), Thevetia peruviana (yellow oleander), Convallaria majalis (lily of the valley), Urginea maritima and Urginea indica (squill), Strophanthus gratus (ouabain), Apocynum cannabinum (dogbane), and Cheiranthus cheiri (wallflower). (medscape.com)
Hispidus2
- Antibacterial and antioxidant activities of Strophanthus hispidus stem aqueous and organic (cyclohexane, chloroform, ethyl acetate and ethanol) extracts were investigated in order to assess its use in traditional medicine. (ijpsr.com)
- The Strophanthus hispidus which belongs to the Apocynaceae family is found all over Africa (D.R. Congo, Senegal, Ghana, Sudan, Uganda and Tanzania) in savannah and forests. (ijpsr.com)
Preussii1
- To evaluate and compare the antioxidant and acetylcholinesterase (AChE)-inhibitory properties of aerial parts of Strophanthus preussii (leaves, stem and root named as SPL, SPS and SPR, respectively) while catechin served as standard. (uwi.edu)
Apocynaceae1
- Strophanthus is a genus of flowering plants in the family Apocynaceae, first described as a genus in 1802. (wikipedia.org)
Kombe1
- Strophanthus kombe Oliv. (malawiflora.com)
Poison2
- Several African tribes used Strophanthus as the principal ingredient in arrow poison. (wikipedia.org)
- a heart poison resembling digitalis or strophanthus in its action. (theodora.com)
Plants1
- Strophanthus in West African plants - A Photo Guide. (wikipedia.org)
Leaves1
- The leaves and root of Strophanthus preusii have proven to be potent natural antioxidants which could justify their traditional use in the management of stress-related diseases. (uwi.edu)
Ouabain1
- ouabain is a rapid-acting glycoside usually obtained from Strophanthus gratus . (medscape.com)
Speciosus1
- Strophanthus speciosus (Ward & Harv. (co.zw)
Hispidus seed1
- Your search for STROPHANTHUS HISPIDUS SEED did not return any results. (nih.gov)
Mother Tincture1
- Strophanthin mother tincture Strophanthus combe. (provitaspharma.com)
Tincture1
- 30206. Adulteration of tincture of strophanthus. (nih.gov)
Ingredient1
- Several African tribes used Strophanthus as the principal ingredient in arrow poison. (wikipedia.org)
Stock1
- Spagyric Strophanthus Seed Extract Is Back In Stock! (drtomcowan.com)