Strychnos nux-vomica
Strychnine
Alkaloids
Plant Extracts
Isostrychnopentamine, an indolomonoterpenic alkaloid from Strychnos usambarensis, induces cell cycle arrest and apoptosis in human colon cancer cells. (1/12)
Isostrychnopentamine (ISP) is an indolomonoterpenic alkaloid that is present in the leaves of Strychnos usambarensis, a well known African shrub or little tree. The roots contain quaternary alkaloids, which are used to make a curare-like arrow poison. However, tertiary alkaloids isolated from the same plant possess cytotoxic activities against mammalian cells and protozoa. The effect of ISP has been investigated on the growth and viability of HCT-116 colon cancer cells during their exponentially growing phase. ISP induced apoptotic cell death as shown by the translocation of phosphatidylserine from the inner layer to the outer layer of the plasma membrane, chromatin condensation, DNA fragmentation, and caspase-3 and -9 activation. ISP provoked also cell cycle arrest in the G(2)-M phase. We also showed that the expression of p53 was not modified in ISP-treated cells, but that p21 was induced in a p53-independent manner. Finally, we demonstrated that ISP did not affect the catalytic activity of human topoisomerases I and II. In conclusion, ISP, which promotes cell death by a p53-independent apoptotic pathway, could be an interesting lead for cancer chemotherapy. (+info)Evaluation of Strychnos pseudoquina ST. HIL. leaves extract on gastrointestinal activity in mice. (2/12)
Strychnos pseudoquina ST. HIL. (Loganiaceae) was investigated for its ability to protect the gastric mucosa against injuries caused by non-steroidal anti-inflammatory drugs (piroxicam) and a necrotizing agent (HCl/EtOH) in mice. The MeOH extract and enriched alkaloidic fraction (EAF) provided significant protection in experimental models wheer used at doses of 250 and 1000 mg/kg. In vivo tests were carried out to evaluate for possible toxic effects and no mortality was observed up to the 5 g/kg dose level. Phytochemical investigation led to the isolation of a new indole alkaloid, which elucidated the observed pharmacological effects. (+info)Development and validation of a TLC-densitometric method for the simultaneous quantitation of strychnine and brucine from Strychnos spp. and its formulations. (3/12)
A simple, sensitive, and specific thin-layer chromatography densitometric method has been developed for the simultaneous quantitation of strychnine and brucine. These two marker compounds are quantitated in the seeds of Strychnos nux-vomica, Strychnos ignatii, and its formulations. The method involves densitometric evaluation of strychnine and brucine after resolving it by high-performance TLC on silica gel plate with toluene-ethyl acetate-diethyl amine-methanol (7:2:1:0.3 v/v) as the mobile phase. The method is validated for precision (interday and intraday), repeatability, and accuracy. The relationship between the concentration of standard solutions and the peak response is linear within the concentration range of 160 to 480 ng/spot for strychnine and 80 to 480 ng/spot for brucine. Instrumental precision is found to be 0.54 and 0.78 (% CV), and repeatability of the method is 1.01 and 1.06 (% CV) for strychnine and brucine, respectively. Accuracy of the method is checked by recovery study conducted at three different levels and the average percentage recovery is found to be 99.13% for strychnine and 100.16% for brucine. The proposed HPTLC method for the simultaneous quantitation of strychnine and brucine is found to be simple, precise, specific, sensitive, and accurate, and it can be used for routine quality control of raw material of Strychnos spp. It also can be applied in quantitating any of these marker compounds in other formulations. (+info)Total synthesis of the strychnos alkaloid (+)-minfiensine: tandem enantioselective intramolecular Heck-iminium ion cyclization. (4/12)
(+info)Evaluation of hypoglicemic activity and healing of extract from amongst bark of "Quina do Cerrado" (Strychnos pseudoquina ST. HILL). (5/12)
(+info)Iodine-catalyzed etherification of morroniside. (6/12)
In this study, we describe a highly selective etherification procedure of unprotected morroniside catalyzed by molecular iodine in acetone. The etherification reaction furnished 7-O-alkyl ether derivatives in reasonable yields within few hours under neutral conditions. Studies of the obtained products on cytotoxicity activity in colon 26-L5 cell line were examined. Among the tested compounds, 7-O-dodecylmorroniside showed moderate cytotoxic activity, having IC50 values equal to 20.9 microM. (+info)Evaluation of antiarthritic activity of Strychnos potatorum Linn seeds in Freund's adjuvant induced arthritic rat model. (7/12)
(+info)Can a Strychnos species be used as antiulcer agent? Ulcer healing action from alkaloid fraction of Strychnos pseudoquina St. Hil. (Loganiaceae). (8/12)
(+info)"Strychnos" is a genus of plants, specifically belonging to the Loganiaceae family. While not a medical term itself, certain species of Strychnos contain toxic alkaloids that have been used in medicine and are important to understand from a medical and pharmacological perspective.
The most well-known species is Strychnos nux-vomica, which produces the potent alkaloid strychnine. This alkaloid acts as a competitive antagonist at glycine receptors in the central nervous system, leading to uncontrolled muscle contractions, stiffness, and potentially life-threatening convulsions if ingested or otherwise introduced into the body.
Another important alkaloid found in some Strychnos species is brucine, which also has toxic properties, although it is less potent than strychnine. Both of these alkaloids are used in research and have been employed in the past as rodenticides, but their use in medicine is limited due to their high toxicity.
In a medical context, knowing about Strychnos plants and their toxic alkaloids is essential for understanding potential poisonings, recognizing symptoms, and providing appropriate treatment.
'Strychnos nux-vomica' is a plant species also known as the poison nut tree or strychnine tree. Its seeds, known as nux vomica, contain several alkaloids including strychnine and brucine, which have been used in medicine for their stimulant and convulsant properties. However, due to the high toxicity and narrow therapeutic index of these compounds, the use of 'Strychnos nux-vomica' in modern medicine is very limited and generally not recommended.
It's important to note that while some alkaloids found in 'Strychnos nux-vomica' have been used in homeopathy, there is a lack of scientific evidence supporting their efficacy, and they should only be used under the guidance of a qualified healthcare professional.
Strychnine is a highly toxic, colorless, bitter-tasting crystalline alkaloid that is derived from the seeds of the Strychnos nux-vomica tree, native to India and Southeast Asia. It is primarily used in the manufacture of pesticides and rodenticides due to its high toxicity to insects and mammals.
Medically, strychnine has been used in the past as a stimulant and a treatment for various conditions such as asthma, heart failure, and neurological disorders. However, its use in modern medicine is extremely rare due to its narrow therapeutic index and high toxicity.
Strychnine works by blocking inhibitory neurotransmitters in the central nervous system, leading to increased muscle contractions, stiffness, and convulsions. Ingestion of even small amounts can cause severe symptoms such as muscle spasms, rigidity, seizures, and respiratory failure, which can be fatal if left untreated.
It is important to note that strychnine has no legitimate medical use in humans and its possession and use are highly regulated due to its high toxicity and potential for abuse.
"Sophora" does not have a specific medical definition, but it is a term that refers to various species of the Sophora plant genus, which belongs to the Fabaceae (legume) family. Some of these plants have been used in traditional medicine in different cultures.
For instance, Sophora flavescens (Ku Shen) has been used in Traditional Chinese Medicine for its anti-inflammatory, antiviral, and antipyretic properties. It contains several alkaloids, such as matrine and oxymatrine, which have demonstrated pharmacological activities.
Another example is Sophora japonica (Japanese pagoda tree), whose seeds, leaves, and bark have been used in traditional Chinese medicine for treating various conditions like diarrhea, insomnia, and skin diseases. Its active compounds include flavonoids, saponins, and alkaloids, which contribute to its medicinal properties.
It is essential to note that the use of Sophora species or their extracts in a medical context should be based on scientific research and under professional medical supervision due to potential side effects and interactions with other medications.
Alkaloids are a type of naturally occurring organic compounds that contain mostly basic nitrogen atoms. They are often found in plants, and are known for their complex ring structures and diverse pharmacological activities. Many alkaloids have been used in medicine for their analgesic, anti-inflammatory, and therapeutic properties. Examples of alkaloids include morphine, quinine, nicotine, and caffeine.
A plant extract is a preparation containing chemical constituents that have been extracted from a plant using a solvent. The resulting extract may contain a single compound or a mixture of several compounds, depending on the extraction process and the specific plant material used. These extracts are often used in various industries including pharmaceuticals, nutraceuticals, cosmetics, and food and beverage, due to their potential therapeutic or beneficial properties. The composition of plant extracts can vary widely, and it is important to ensure their quality, safety, and efficacy before use in any application.
Phytotherapy is the use of extracts of natural origin, especially plants or plant parts, for therapeutic purposes. It is also known as herbal medicine and is a traditional practice in many cultures. The active compounds in these plant extracts are believed to have various medicinal properties, such as anti-inflammatory, analgesic, or sedative effects. Practitioners of phytotherapy may use the whole plant, dried parts, or concentrated extracts to prepare teas, capsules, tinctures, or ointments for therapeutic use. It is important to note that the effectiveness and safety of phytotherapy are not always supported by scientific evidence, and it should be used with caution and preferably under the guidance of a healthcare professional.
Strychnos
Strychnos madagascariensis
Strychnos elaeocarpa
Strychnos ignatii
Strychnos mellodora
Strychnos benthami
Strychnos toxifera
Strychnos millepunctata
Strychnos pungens
Strychnos staudtii
Strychnos camptoneura
Strychnos alkaloids
Strychnos cocculoides
Strychnos chromatoxylon
Strychnos usambarensis
Strychnos tetragona
Strychnos psilosperma
Strychnos icaja
Strychnos potatorum
Strychnos spinosa
Strychnos nux-vomica
Strychnos nux-blanda
Manuel Córdova-Rios
Wildlife of Zimbabwe
List of Southern African indigenous trees and woody lianes
Cissus
Wieland-Gumlich aldehyde
List of leaf vegetables
List of Australian plant species described by Robert Brown
List of unproven and disproven cancer treatments
Strychnos - Wikipedia
Strychnos nux-vomica | Boiron USA
Strychnos potatorum Archives - Planet Ayurveda
Flora of Zimbabwe: Individual record no: 48050: Strychnos usambarensis
Flora of Malawi: Species information: Records of: Strychnos henningsii
Strychnos castelnaeana - PlantUse English
Strychnos toxifera | QJURE.com
Strychnos phaeotricha - Useful Tropical Plants
Strychnos - Copenhell 2023 - Decibell Media
Strychnos castelnaei: | Henriette's Herbal Homepage
Strychnos tieute - I & E Organics Apothecary
Strychnos Ignatii Herb Uses, Benefits, Cures, Side Effects, Nutrients
O gênero Strychnos (Loganiaceae) no estado do Rio de Janeiro, Brasil
Studies on the Defluoridization Competency of a Mixture of Raw Vermiculite and Strychnos potatorum linn. Seeds
Ultrasound-Assisted Extraction of Antimalarial Compounds from the Bidara Laut (Strychnos ligustrina) Heartwood | Jurnal...
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All Genera of Plants - Alle Gattungen des Pflanzenreichs
Non-Edible Nut-Like Fruits - Innvista
CDC Strychnine | Facts about Strychnine | Public Health Emergency Preparedness& Response
Allison Ledoux - Search Results - PubMed
Nux Vomica and breastfeeding. Are they compatible?
Spinosa8
- Strychnos spinosa Lam. (wikipedia.org)
- Strychnos tonga, native to Tonga, is a synonym of "'Strychnos spinosa. (wikipedia.org)
- Three trees from Southern Africa, commonly known as "monkey oranges", are drought-tolerant and produce popular edible fruits: the corky-barked monkey orange or suurklapper, Strychnos cocculoides, the Natal orange or green or spiny monkey orange, Strychnos spinosa, and the black or spiny-leaved monkey orange Strychnos pungens. (wikipedia.org)
- Strychnos madagascariensis Strychnos nux-vomica flowers Strychnos potatorum Strychnos psilosperma Strychnos pungens flowers Strychnos pungens detached fruit Strychnos spinosa tree in fruit Strychnos usambarensis in flower Strychnos usambarensis in fruit List of Southern African indigenous trees and woody lianes The Plant List Umberto Quattrocchi, CRC World Dictionary of Plant Names : Common Names, Scientific Names, Eponyms. (wikipedia.org)
- This work aims to compile the dispersal data on Strychnos spinosa Lam. (athmsi.org)
- Antitrypanosomal compound from leaf essential oil of Strychnos spinosa. (academicjournals.org)
- Strychnos spinosa is a native tree of tropical and subtropical Africa. (fundacionmona.org)
- Health benefits and biological activities of spiny monkey orange (Strychnos spinosa Lam. (bvsalud.org)
Loganiaceae3
- Strychnos is a genus of flowering plants, belonging to the family Loganiaceae (sometimes Strychnaceae). (wikipedia.org)
- The dried seed of the Strychnos nux-vomica plant of the Loganiaceae family is used. (e-lactancia.org)
- Brucine is an alkaloid obtained from strychnos seeds: (Strychnos nux-vomica L. and s. ignatii Berg, Loganiaceae). (inchem.org)
Ignatii6
- Strychnos ignatii P.J. Bergius Strychnos madagascariensis Poir. (wikipedia.org)
- Strychnos ignatii ("St. Ignatius bean"), is a closely related Asian shrub/tree. (wikipedia.org)
- Strychnos Ignatii plant is used to prepare Homeopathic Remedy known as Ignatia Amara. (herbpathy.com)
- We wanner buy Strychnos ignatii Berg. (ecplaza.net)
- Strychnos Ignatii also called Ignatia Amara, Ignatius Bean or Ignatia is first aid for when the thermometer system of our body fails and this article lists my top 6 situations in which Ignatia is a powerful medicine that few other herbs can match in those situations. (herbal-treatments.com)
- Strychnine is a toxic alkaloid derived from the seeds of the trees Strychnos nux vomica , Strychnos ignatii (S. sancta Ingnatius), and Strychnos tiente (Upas tree), that can be found in India, southern Asia, northern Australia, and Hawaii. (cdc.gov)
Vomica6
- Strychnos nux-blanda A.W.Hill - (Assam to Southeast Asia) Strychnos nux-vomica L. Strychnos potatorum L.f. (wikipedia.org)
- The strychnine tree, Strychnos nux-vomica, native to tropical Asia, is the source of the poison strychnine. (wikipedia.org)
- Strychnos nux-vomica New species of ancient tropical flower found in amber from the Dominican Republic, Rachel Sullivan, ABC News Online, 16 February 2016 George Poinar Jr. and Lena Struwe (2016). (wikipedia.org)
- Also known as nux vomica , poison nut , semen strychnos and quaker buttons , the medium-sized strychnine tree is native to South East Asia and Australia. (australiangeographic.com.au)
- The primary natural source of strychnine is the plant Strychnos nux-vomica . (cdc.gov)
- Nux vomica (dried ripe seeds of Strychnos nux) contains strychnine and brucine and is used in the preparation of homeopathic medicine. (inchem.org)
Potatorum3
- Katak / Clearing Nut (Strychnos Potatorum)- Ayurvedic Properties, Effects On Doshas & Dosage Description Ayurveda is the oldest science in the world that helps the human body to regain its strength and to promote longevity with proper maintenance. (planetayurveda.com)
- Studies on the Defluoridization Competency of a Mixture of Raw Vermiculite and Strychnos potatorum linn. (derpharmachemica.com)
- Strychnos potatorum Linn. (derpharmachemica.com)
Gilg3
- Strychnos elaeocarpa Gilg ex Leeuwenb. (wikipedia.org)
- Strychnos staudtii Gilg Strychnos tetragona A.W.Hill Strychnos toxifera R.H.Schomb. (wikipedia.org)
- Strychnos usambarensis Gilg ex Engl. (wikipedia.org)
Seeds2
- It is a virulent poison produced in the seeds of plants of the Strychnos genus. (acs.org)
- Agriculture - Brucine and the other alkaloids obtained from the seeds of Strychnos have been used for destroying birds, rodents, moles and predatory animals (Vallet, 1964). (inchem.org)
Toxifera1
- The species Strychnos toxifera, a principal plant source of the arrow poison curare. (wikipedia.org)
Baill1
- Strychnos icaja Baill. (wikipedia.org)
Species2
- Mrs Grieve's Herbal of 1931 also mentions traditional water purification uses of an Indian species called Strychnos pseudo (not a valid botanical name). (wikipedia.org)
- a species of Strychnos . (freedictionary.org)
Shrub1
- Strychnos phaeotricha is a climbing shrub producing stems that can be up to 50 metres long and 2 - 7cm in diameter. (theferns.info)
Plants1
- The meaning of the word strychnos was not fixed in Ancient Greece, where it could designate a variety of different plants having in common the property of toxicity. (wikipedia.org)
Latin1
- Two very well preserved fossilised corollas with stamens and styles from flowers of a plant that has been named Strychnos electri (the Latin name of amber is electrum), believed to be a vine, were discovered in amber from the Dominican Republic. (wikipedia.org)
Activity2
- The aqueous wood extract of bidara laut ( Strychnos ligustrina ) from maceration demonstrated the greatest antimalarial activity against Plasmodium falciparum strain 3D7. (unila.ac.id)
- In vitro antiviral activity against SARS-CoV-2 of 28 Strychnos extracts. (nih.gov)
Madagascariensis2
- Strychnos ignatii P.J. Bergius Strychnos madagascariensis Poir. (wikipedia.org)
- Strychnos madagascariensis Poir. (zambiaflora.com)
Mitis5
- The present study aimed to evaluate antiplasmodial activity and acute toxicity of the plant Strychnos mitis in Plasmodium berghei infected mice. (biomedcentral.com)
- Standard procedures were employed to investigate acute toxicity and 4-day suppressive effect of crude aqueous and hydro-methanolic extracts of the leaves of Strychnos mitis against P. berghei in Swiss albino mice. (biomedcentral.com)
- All doses of crude extracts and fractions of leaves of Strychnos mitis prolonged survival time of infected mice dose dependently. (biomedcentral.com)
- The results of this study provide support the traditional therapeutic use of Strychnos mitis for treatment of malaria. (biomedcentral.com)
- This group fed extensively on the ripe fruits of Strychnos mitis during September and October, 1993. (asp.org)
Mellodora2
- Strychnos mellodora S. Moore Strychnos millepunctata Leeuwenb. (wikipedia.org)
- It is possible the same name was included from a different data source, to check this you can search for Strychnos mellodora in version 1 of The Plant List . (theplantlist.org)
Ignatii seed1
- Your search for STRYCHNOS IGNATII SEED did not return any results. (nih.gov)
Soler1
- Strychnos pungens Soler. (wikipedia.org)
Electri1
- Two very well preserved fossilised corollas with stamens and styles from flowers of a plant that has been named Strychnos electri (the Latin name of amber is electrum), believed to be a vine, were discovered in amber from the Dominican Republic. (wikipedia.org)
Alkaloids2
- Investigations also reveal that, according to the GL, powder samples for the manufacturing of pCms by Kin Lam contain strychnos alkaloids and sophora alkaloids, which should not be present therein. (gov.hk)
- Strychnos alkaloids, existing in Chinese herbal medicines such as Semen Strychni, may cause muscle spasm and convulsion. (gov.hk)
SEED2
Soil1
- Effect of Soil Amendments to Survival Rate of Bidara Laut (Strychnos lucida R.Br. (ugm.ac.id)
Bean1
- Strychnos ignatii ("St. Ignatius bean"), is a closely related Asian shrub/tree. (wikipedia.org)
Tree1
- Strychnos is a deciduous Tree growing to 12 m (39ft) by 12 m (39ft) at a slow rate. (pfaf.org)